<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN" "http://jats.nlm.nih.gov/publishing/1.2/JATS-journalpublishing1.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="research-article" dtd-version="1.2" xml:lang="en">
    <front>
        <journal-meta>
            <journal-id journal-id-type="pmc">F1000Research</journal-id>
            <journal-title-group>
                <journal-title>F1000Research</journal-title>
            </journal-title-group>
            <issn pub-type="epub">2046-1402</issn>
            <publisher>
                <publisher-name>F1000 Research Limited</publisher-name>
                <publisher-loc>London, UK</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="doi">10.12688/f1000research.72824.2</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Research Article</subject>
                </subj-group>
                <subj-group>
                    <subject>Articles</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Status of self-esteem in medical students at a college in Kathmandu: A descriptive cross-sectional study</article-title>
                <fn-group content-type="pub-status">
                    <fn>
                        <p>[version 2; peer review: 2 approved, 1 approved with reservations]</p>
                    </fn>
                </fn-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Shrestha</surname>
                        <given-names>Bikal</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Software</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="yes">
                    <name>
                        <surname>Yadav</surname>
                        <given-names>Stuti</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Resources</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0001-5272-8034</uri>
                    <xref ref-type="corresp" rid="c1">a</xref>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Dhakal</surname>
                        <given-names>Subodh</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Software</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0001-8269-4517</uri>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Ghimire</surname>
                        <given-names>Pooja</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Shrestha</surname>
                        <given-names>Yubika</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Singh Rathaure</surname>
                        <given-names>Ela</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-7910-0025</uri>
                    <xref ref-type="aff" rid="a2">2</xref>
                </contrib>
                <aff id="a1">
                    <label>1</label>Nepalese Army Institute of Health Sciences (NAIHS), Kathmandu, 44600, Nepal</aff>
                <aff id="a2">
                    <label>2</label>Epidemiology and Disease control division, USAID, Kathmandu, 44600, Nepal</aff>
            </contrib-group>
            <author-notes>
                <corresp id="c1">
                    <label>a</label>
                    <email xlink:href="mailto:stuti4542@gmail.com">stuti4542@gmail.com</email>
                </corresp>
                <fn fn-type="conflict">
                    <p>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>11</day>
                <month>4</month>
                <year>2022</year>
            </pub-date>
            <pub-date pub-type="collection">
                <year>2021</year>
            </pub-date>
            <volume>10</volume>
            <elocation-id>1031</elocation-id>
            <history>
                <date date-type="accepted">
                    <day>5</day>
                    <month>4</month>
                    <year>2022</year>
                </date>
            </history>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2022 Shrestha B et al.</copyright-statement>
                <copyright-year>2022</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <self-uri content-type="pdf" xlink:href="https://f1000research.com/articles/10-1031/pdf"/>
            <abstract>
                <p>
                    <bold>Background:</bold>&#x00a0;Self-esteem is vital to living&#x00a0;a&#x00a0;happy, confident and content life. Medical students experience various forms of stress due to academic, financial and social pressures&#x00a0;which could affect their levels&#x00a0;of self-esteem. This study aims to study the status of self-esteem among undergraduates of a medical college&#x00a0;at&#x00a0;Tribhuvan University, Nepal.&#x00a0;</p>
                <p>
                    <bold>Methods:</bold>&#x00a0;After receiving the ethical approval from the Institutional Review Committee (IRC) of NAIHS; we conducted&#x00a0;a&#x00a0;descriptive&#x00a0;cross-sectional&#x00a0;study among the first-&#x00a0;to fifth-year medical students from December 2020 to April 2021. 190 were selected for the study using&#x00a0;a&#x00a0;stratified random sampling technique. This study used the Rosenberg&#x00a0;self-esteem scale to measure self&#x2013;esteem of the participants.&#x00a0;A&#x00a0;Google Forms&#x00a0;questionnaire&#x00a0;was sent&#x00a0;to the participants via email. Then, the data obtained were entered in the Google sheet and later analyzed using SPSS 27.&#x00a0;A&#x00a0;Chi-square test was used to&#x00a0;identify potential&#x00a0;differences in self-esteem scores&#x00a0;among different variables. A p-value of &lt; 0.05 was considered statistically significant.&#x00a0;</p>
                <p> &#x00a0;&#x00a0;</p>
                <p>
                    <bold>Results:</bold>&#x00a0;This study included a total of 180 participants, among which, 18.9% (13.19% to 24.61%; at 95% CI) students showed low self-esteem. 74.4% (68.02% to 80.78%; at 95% CI) students had normal self-esteem and 6.7% (3.05% to 10.35%; at 95% CI) students had high self-esteem. The mean self-esteem score was 19.19 (15.01 to 23.37; at 95% CI). Female participants suffered more than males&#x00a0;from low self-esteem and third-year students had the highest percentage of low self-esteem (30.77%).&#x00a0;</p>
                <p>
                    <bold>Conclusion:</bold>&#x00a0;The majority (74.4%) of medical students had normal self-esteem. However, 18.9% students had low self-esteem, among which, third-year students suffered the most (30.77%). Likewise,&#x00a0;females exhibited higher prevalence of low self-esteem compared to males. Interventions to boost the level of self-esteem should be carried out to help&#x00a0;medical students&#x00a0;become confident and efficient doctors.</p>
            </abstract>
            <kwd-group kwd-group-type="author">
                <kwd>self-esteem</kwd>
                <kwd>college</kwd>
                <kwd>medical students</kwd>
                <kwd>Kathmandu</kwd>
                <kwd>Nepal</kwd>
                <kwd>undergraduates</kwd>
                <kwd>doctors</kwd>
                <kwd>self-perception</kwd>
            </kwd-group>
            <funding-group>
                <funding-statement>The author(s) declared that no grants were involved in supporting this work.</funding-statement>
            </funding-group>
        </article-meta>
        <notes>
            <sec sec-type="version-changes">
                <label>Revised</label>
                <title>Amendments from Version 1</title>
                <p>This version of the article has been updated in the Introduction and Discussion sections, including new references.</p>
            </sec>
        </notes>
    </front>
    <body>
        <sec id="sec1" sec-type="intro">
            <title>Introduction</title>
            <p>Self-esteem is one&#x2019;s sense of self-worth, acceptance, and confidence that individuals feel toward themselves.
                <sup>
                    <xref ref-type="bibr" rid="ref1">1</xref>
                </sup> Mentally and physically active people are the foundation of a healthy society and serve the community. Doctors and medical students in particular must have a healthy mental state. A doctor suffering from anxiety, dissatisfaction, and low self-esteem will not be able to fulfil his/her duty properly,
                <sup>
                    <xref ref-type="bibr" rid="ref2">2</xref>
                </sup> and a medical student with low self-esteem will never grow to become a healthy, efficient doctor.</p>
            <p>Having balanced self-esteem is highly important for healthcare professionals, including medical students.
                <sup>
                    <xref ref-type="bibr" rid="ref3">3</xref>
                </sup> Medical students undergo major stress in the form of academic workload,
                <sup>
                    <xref ref-type="bibr" rid="ref4">4</xref>
                </sup> family expectations, peer pressure, financial issues
                <sup>
                    <xref ref-type="bibr" rid="ref5">5</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref6">6</xref>
                </sup> and excessive working hours.
                <sup>
                    <xref ref-type="bibr" rid="ref5">5</xref>
                </sup>
                <sup>-</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref7">7</xref>
                </sup> Studies show that a large proportion of medical students are unhappy and have low self-esteem,
                <sup>
                    <xref ref-type="bibr" rid="ref8">8</xref>
                </sup> and that students with low self-esteem are likely to suffer&#x00a0;from anxiety and&#x00a0;mental breakdowns, doubt themselves and feel a sense of inadequacy.
                <sup>
                    <xref ref-type="bibr" rid="ref9">9</xref>
                </sup> These students tend to appear less competent among their peers
                <sup>
                    <xref ref-type="bibr" rid="ref10">10</xref>
                </sup> which contributes to depression and unhappiness. Self-development and well-being is also negatively affected by inadequate self-esteem.
                <sup>
                    <xref ref-type="bibr" rid="ref8">8</xref>
                </sup>
            </p>
            <p>Self-esteem influences a student's performance, as well as their physical and psychological health and therefore is important to&#x00a0;be maintained. A person who has high self-esteem can cope more effectively with stress and anxiety-inducing events in life without any negativity or impact on their mental health.
                <sup>
                    <xref ref-type="bibr" rid="ref11">11</xref>
                </sup> It helps one to foster confidence, appear competent among their colleagues, tackle challenges with optimism and take on criticism without it affecting their self-image.
                <sup>
                    <xref ref-type="bibr" rid="ref8">8</xref>
                </sup>
            </p>
            <p>In Nepal, studies evaluating the self-esteem of medical students are lacking, but existing literature studying nursing students found that nearly 78% of the students had low self-esteem.
                <sup>
                    <xref ref-type="bibr" rid="ref12">12</xref>
                </sup> This study uses Rosenberg Self Esteem Scale (RSES). It is a widely and commonly used scale for measuring self-esteem.
                <sup>
                    <xref ref-type="bibr" rid="ref12">12</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref13">13</xref>
                </sup> It classifies self-esteem as high, normal and low self esteem based on the scores obtained.
                <sup>
                    <xref ref-type="bibr" rid="ref13">13</xref>
                </sup>
            </p>
            <p>Assessing medical students&#x2019; self-esteem and designing necessary interventions for students with inadequate self-esteem can help us produce confident and optimistic doctors. Since confidence is regarded as a subjective marker of competence,
                <sup>
                    <xref ref-type="bibr" rid="ref14">14</xref>
                </sup> we can expect to produce highly competent doctors from the timely intervention. Having this competency in student life will help them acquire good knowledge and later, as a doctor, enable them to effectively manage patients. This study aims to report the status of self-esteem among medical students at a college&#x00a0;in Kathmandu.</p>
        </sec>
        <sec id="sec2" sec-type="methods">
            <title>Methods</title>
            <sec id="sec3">
                <title>Study design and setting</title>
                <p>A descriptive cross-sectional study was conducted from December 2020 to April 2021. Data collection took place from 30
                    <sup>th</sup> of December, 2020 to 25
                    <sup>th</sup> of January, 2021 among medical students at the Nepalese Army Institute of Health Sciences-College of Medicine (NAIHS-COM) situated in Kathmandu. Medical undergraduates from all years of study were included in the study. The study was conducted after receiving ethical approval from the Institutional Review Committee (IRC), NAIHS; on December 2020 (Reg. No. 373).</p>
            </sec>
            <sec id="sec4">
                <title>Sample size</title>
                <p>We calculated the adequate sample size using the formula for infinite population and then adjusted it according to our population size. Based on Syed 
                    <italic toggle="yes">et al</italic>&#x2019;s study, we estimated the proportion of students with low self-esteem to be 18%.
                    <sup>
                        <xref ref-type="bibr" rid="ref15">15</xref>
                    </sup> Using this estimation, we calculated the minimum sample size that could represent our population.
                    <disp-formula id="e1">
                        <mml:math display="block">
                            <mml:mi mathvariant="normal">N</mml:mi>
                            <mml:mo>=</mml:mo>
                            <mml:mi mathvariant="normal">z</mml:mi>
                            <mml:mo>^</mml:mo>
                            <mml:mn>2</mml:mn>
                            <mml:mspace width="0.25em"/>
                            <mml:mo>&#x00d7;</mml:mo>
                            <mml:mspace width="0.25em"/>
                            <mml:mi mathvariant="normal">p</mml:mi>
                            <mml:mspace width="0.25em"/>
                            <mml:mo>&#x00d7;</mml:mo>
                            <mml:mspace width="0.25em"/>
                            <mml:mfenced>
                                <mml:mrow>
                                    <mml:mn>1</mml:mn>
                                    <mml:mo>&#x2212;</mml:mo>
                                    <mml:mi mathvariant="normal">p</mml:mi>
                                </mml:mrow>
                            </mml:mfenced>
                            <mml:mo>/</mml:mo>
                            <mml:msup>
                                <mml:mi mathvariant="normal">d</mml:mi>
                                <mml:mn>2</mml:mn>
                            </mml:msup>
                        </mml:math>
                    </disp-formula>
                </p>
                <p>[where, N = sample size for infinite population, z = factor to achieve (1 &#x2212; a) % level of confidence (z = 1.96 at 95% C.I) p = estimated rate of population proportion i.e. 18% here.
                    <sup>
                        <xref ref-type="bibr" rid="ref15">15</xref>
                    </sup> d = margin of error to be tolerated (5% here)]
                    <disp-formula id="e2">
                        <mml:math display="block">
                            <mml:mi mathvariant="normal">N</mml:mi>
                            <mml:mo>=</mml:mo>
                            <mml:mfenced close=")" open="(">
                                <mml:mn>1.96</mml:mn>
                            </mml:mfenced>
                            <mml:mo>^</mml:mo>
                            <mml:mn>2</mml:mn>
                            <mml:mspace width="0.25em"/>
                            <mml:mo>&#x00d7;</mml:mo>
                            <mml:mspace width="0.25em"/>
                            <mml:mn>0.18</mml:mn>
                            <mml:mspace width="0.25em"/>
                            <mml:mo>&#x00d7;</mml:mo>
                            <mml:mspace width="0.25em"/>
                            <mml:mfenced close=")" open="(">
                                <mml:mrow>
                                    <mml:mn>1</mml:mn>
                                    <mml:mo>&#x2212;</mml:mo>
                                    <mml:mn>0.18</mml:mn>
                                </mml:mrow>
                            </mml:mfenced>
                            <mml:mo>/</mml:mo>
                            <mml:mn>0.05</mml:mn>
                            <mml:mo>^</mml:mo>
                            <mml:mn>2</mml:mn>
                        </mml:math>
                    </disp-formula>
                    <disp-formula id="e3">
                        <mml:math display="block">
                            <mml:mi mathvariant="normal">N</mml:mi>
                            <mml:mo>=</mml:mo>
                            <mml:mn>226.80</mml:mn>
                            <mml:mspace width="3em"/>
                            <mml:mi mathvariant="normal">i</mml:mi>
                            <mml:mo>.</mml:mo>
                            <mml:mi mathvariant="normal">e</mml:mi>
                            <mml:mo>.</mml:mo>
                            <mml:mn>227</mml:mn>
                        </mml:math>
                    </disp-formula>
                </p>
                <p>For our study population, adjusted sample size is:
                    <disp-formula id="e4">
                        <mml:math display="block">
                            <mml:mi mathvariant="normal">n</mml:mi>
                            <mml:mo>=</mml:mo>
                            <mml:mi mathvariant="normal">N</mml:mi>
                            <mml:mo>/</mml:mo>
                            <mml:mfenced close=")" open="(">
                                <mml:mrow>
                                    <mml:mn>1</mml:mn>
                                    <mml:mo>+</mml:mo>
                                    <mml:mfenced close=")" open="(">
                                        <mml:mrow>
                                            <mml:mi mathvariant="normal">N</mml:mi>
                                            <mml:mo>&#x2212;</mml:mo>
                                            <mml:mn>1</mml:mn>
                                            <mml:mo>/</mml:mo>
                                            <mml:mi mathvariant="normal">P</mml:mi>
                                        </mml:mrow>
                                    </mml:mfenced>
                                </mml:mrow>
                            </mml:mfenced>
                        </mml:math>
                    </disp-formula>
                </p>
                <p>[where, n = adjusted sample size for our finite population, P = our study population i.e. 550 students.]
                    <disp-formula id="e5">
                        <mml:math display="block">
                            <mml:mi mathvariant="normal">n</mml:mi>
                            <mml:mo>=</mml:mo>
                            <mml:mn>227</mml:mn>
                            <mml:mo>/</mml:mo>
                            <mml:mfenced close=")" open="(">
                                <mml:mrow>
                                    <mml:mn>1</mml:mn>
                                    <mml:mo>+</mml:mo>
                                    <mml:mn>226</mml:mn>
                                    <mml:mo>/</mml:mo>
                                    <mml:mn>550</mml:mn>
                                </mml:mrow>
                            </mml:mfenced>
                            <mml:mo>=</mml:mo>
                            <mml:mn>160.89</mml:mn>
                            <mml:mspace width="3em"/>
                            <mml:mi mathvariant="normal">i</mml:mi>
                            <mml:mo>.</mml:mo>
                            <mml:mi mathvariant="normal">e</mml:mi>
                            <mml:mo>.</mml:mo>
                            <mml:mn>161</mml:mn>
                        </mml:math>
                    </disp-formula>
                </p>
                <p>Hence, our sample size (n) is 161.</p>
                <p>Adjusting the sample size by taking non-response rate at 15%, the final sample size becomes 190.</p>
            </sec>
            <sec id="sec5">
                <title>Sampling strategy and eligibility criteria</title>
                <p>Students 18 years or older who gave consent were eligible to participate in the study. For the purpose of sampling, students were divided into two strata: pre-clinical (first, second) and clinical year (third, fourth, fifth). This was done because students of pre-clinical years shared some&#x00a0;common characteristics &#x2013; such as studying basic medical subjects without clinical exposure, while students of clinical years had clinical exposure. Students were selected through a Proportionate Stratified Random sampling technique so that every student from the first to fifth year had an equal probability of being selected in the study. This would ensure that the sample within each stratum properly represented our study population. The sampling frame was prepared by collecting the list of students from administrative section of the institute, who were numbered from 1 to 550. Within that limit, 190 random numbers were generated with the help of Google Random Number Generator as per the proportion of students from each year and the proportion of males and females in each year. The random numbers that would represent the student researchers involved in this study were excluded.</p>
            </sec>
            <sec id="sec6">
                <title>Survey instrument</title>
                <p>To measure self-esteem, we used a questionnaire based on the Rosenberg Self Esteem Scale (RSES).
                    <sup>
                        <xref ref-type="bibr" rid="ref13">13</xref>
                    </sup>
                    <sup>,</sup>
                    <sup>
                        <xref ref-type="bibr" rid="ref16">16</xref>
                    </sup>
                    <sup>,</sup>
                    <sup>
                        <xref ref-type="bibr" rid="ref17">17</xref>
                    </sup> The questionnaire had two parts; demographic details and the Rosenberg Self Esteem Scale. Demographic details covered general information including: age, sex, province of permanent address, year of study and type of institution they&#x00a0;had attended for primary level education. A copy of the questionnaire can be found in the extended data.
                    <sup>
                        <xref ref-type="bibr" rid="ref18">18</xref>
                    </sup>
                </p>
                <p>The RSES was developed by sociologist Morris Rosenberg.
                    <sup>
                        <xref ref-type="bibr" rid="ref16">16</xref>
                    </sup> It is a 10-item Likert-type scale with items answered on a four-point scale from strongly agree to strongly disagree. For items 1, 3, 4, 7, 10: Strongly Agree = 3, Agree = 2, Disagree = 1, and Strongly Disagree = 0. For items 2, 5, 6, 8, 9 (which are negative statements; hence reversed in score): Strongly Agree = 0, Agree = 1, Disagree = 2, and Strongly Disagree = 3.
                    <sup>
                        <xref ref-type="bibr" rid="ref16">16</xref>
                    </sup>
                    <sup>,</sup>
                    <sup>
                        <xref ref-type="bibr" rid="ref18">18</xref>
                    </sup> A total is obtained by adding these markings which ranges from 0&#x2013;30. A score less than 16 indicates low self-esteem, more than 25 indicated high self-esteem and scores from 16 to 25 shows normal self-esteem in the respondents.
                    <sup>
                        <xref ref-type="bibr" rid="ref13">13</xref>
                    </sup>
                    <sup>,</sup>
                    <sup>
                        <xref ref-type="bibr" rid="ref17">17</xref>
                    </sup>
                </p>
                <p>The RSES has high reliability: test-retest correlations are in the range of .82 to .88 and Cronbach's alpha for various samples are in the range of&#x00a0;&#x00a0;.77 to&#x00a0;&#x00a0;.88.
                    <sup>
                        <xref ref-type="bibr" rid="ref19">19</xref>
                    </sup>
                    <sup>,</sup>
                    <sup>
                        <xref ref-type="bibr" rid="ref20">20</xref>
                    </sup> We also calculated Cronbach&#x2019;s alpha for our study sample and the value for it was 0.811 which showed good internal consistency and reliability of the instrument for our population as well.</p>
            </sec>
            <sec id="sec7">
                <title>Data collection and statistical analysis</title>
                <p>The questionnaire was sent to 190 students through Google forms via email. Out of 190 students, 182 responded among which 2 refused to give consent. Hence, we obtained complete data from 180 students which was then entered into a Google spreadsheet
                    <sup>
                        <xref ref-type="bibr" rid="ref18">18</xref>
                    </sup> and later analyzed using Microsoft Excel and SPSS version 27.&#x00a0;Chi Square Test of Association was used to compare between and among different categorical variables by taking the median values of RSES score. A p-value of &lt; 0.05 was considered statistically significant.</p>
            </sec>
            <sec id="sec8">
                <title>Potential biases</title>
                <p>The participant responses could have been subjected to response bias and subjective bias. Response bias includes responding to questionnaire items without understanding them and also giving socially desirable answers. Subjective bias could have occurred as the questionnaire is based on the subjective feelings of the respondents. We could not control subjective bias as it is inevitable when measuring&#x00a0;abstract parameters such as self-esteem. But for response bias, we employed certain techniques to minimize it as far as possible. The questionnaire was self-administered, without individual interpretation by the researcher, but with explanation for some possible ambiguities in it. We checked the clarity of the items by translating the items to Nepali and retranslating it back to English with the help of two individuals who were not involved in the study. Moreover, we assured participants regarding concealed identity and confidentiality issues at the beginning and the Likert scale used was a 4-point Likert without the neutral responding.</p>
            </sec>
            <sec id="sec9">
                <title>Ethical statement</title>
                <p>Ethical approval was obtained from the Institutional Review Committee (IRC), NAIHS in December 2020 (Reg. No. 373). There was no patient or public involvement in the design, conduct or reporting of our research. The first section of our Google forms survey had an information sheet with information about our study and an informed consent section where the participants could choose to agree or disagree to participate in the study via a tick-box. Participants who chose to agree could proceed to the questionnaire section. They were informed that their identity would be concealed and their de-identified data would be accessed only by the researchers. In this way, only after obtaining informed consent, the randomly selected medical students were involved as participants for data collection.</p>
            </sec>
        </sec>
        <sec id="sec10" sec-type="results">
            <title>Results</title>
            <p>180 responses were received from 190 study participants (94.73% response rate). Out of the&#x00a0;180 participants, 123 (68.3%) were male and 57 (31.7%) were female. Majority of the respondents were from clinical years (third, fourth and fifth year) making up 63.5%, whereas only 36.1% respondents were from Pre-Clinical years (first and second year). The average age of the students was 22.17 &#x00b1; 1.78 years. The mean self-esteem score of the respondents was 19.19 &#x00b1; 4.18 (15.01 to 23.37 at 95% CI) which lies in the normal range of RSES score.</p>
            <p>Among 180 participants, 18.9% (13.19 to 24.61 at 95% CI) were found to have low self-esteem. 74.4% (68.02% to 80.78% at 95% CI) students had normal self-esteem and 6.7% (3.05% to 10.35% at 95% CI) students had high self-esteem.</p>
            <p>Female participants were found to have suffered lower self-esteem than males. The mean self-esteem score of males was 19.63 &#x00b1; 4.29 and that of females was 18.26 &#x00b1; 3.81. There is an association between sex and median values of RSES scores (i.e., whether students had higher or lower self-esteem than the median value). Significant difference in self-esteem was found between males and females at 5% level of significance (&#x03c7; 
                <sup>2</sup> = 4.33, p = 0.037). Not enough evidence was found to suggest a significant difference in RSES scores between and among any other variables. Out of 65 pre-clinical year students, 11 (16.92%) and out of 115 clinical year students 23 (20%) were found to have low self-esteem. Third&#x00a0;year medical students had the highest percentage of low self-esteem i.e., 12 (30.77%) as shown in 
                <xref ref-type="table" rid="T1">Table 1</xref>.</p>
            <table-wrap id="T1" orientation="portrait" position="float">
                <label>Table 1. </label>
                <caption>
                    <title>Socio-demographic characteristics and RSES of the students along with p- value.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="2" rowspan="2" valign="top">Variables</th>
                            <th align="left" colspan="3" rowspan="1" valign="top">RSES SCORE</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Total</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">p-value</th>
                        </tr>
                        <tr>
                            <th align="left" colspan="1" rowspan="1" valign="top">&lt; 16</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">16 &#x2013; 25</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">&gt;25</th>
                            <th align="left" colspan="1" rowspan="1" valign="top"/>
                            <th align="left" colspan="1" rowspan="1" valign="top"/>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="2" valign="top">
                                <bold>Sex</bold>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Male</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">22 (17.89%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">91 (73.98%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">10 (8.13%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">123</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.037</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Female</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">12 (21.05%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">43 (75.44%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2 (3.51%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">57</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="2" valign="top">
                                <bold>Type of primary schooling</bold>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Government</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2 (10%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">16 (80%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2 (10%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">20</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.508</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Private</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">32 (20%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">118 (73.75%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">10 (6.25%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">160</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="5" valign="top">
                                <bold>Year of medical college</bold>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">First year</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">6 (17.65%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">26 (76.47%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2 (5.88%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">34</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.660</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Second year</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">5 (16.13%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">23 (74.19%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3 (9.68%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">31</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Third year</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">12 (30.77%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">25 (64.10%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2 (5.13%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">39</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Fourth year</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">5 (14.71%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">28 (82.35%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 (2.94%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">34</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Fifth year</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">6 (14.29%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">32 (76.19%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4 (9.52%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">42</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="2" valign="top">
                                <bold>Level of education</bold>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Pre-clinical</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">11 (16.92%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">49 (75.38%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">5 (7.69%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">65</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.972</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Clinical</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">23 (20%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">85 (73.91%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">7 (6.09%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">115</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="7" valign="top">
                                <bold>Province</bold>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Province No. 1</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 (9.09%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">9 (81.82%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 (9.09%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">11</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.939</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Province No. 2</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">9 (26.47%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">23 (67.65%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2 (5.88%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">34</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Bagmati Province</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">13 (16.25%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">61 (76.25%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">6 (7.5%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">80</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Gandaki Province</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">5 (20.83%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (75.00%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 (4.17%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">24</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Lumbini Province</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">5 (21.74%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">16 (69.57%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2 (8.7</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">23</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Karnali Province</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0 (0%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3 (100%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0 (0%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Sudurpashchim Province</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 (20.00%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4 (80.00%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0 (0%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">5</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                    </tbody>
                </table>
            </table-wrap>
            <p>It was found that 20% (14.16% to 25.84% at 95% CI) of the students who had attended private school for their primary level of schooling had low self-esteem whereas its prevalence among government school students was reported to be 10% (5.62% to 14.38% at 95% CI). Further details of the findings have been presented in 
                <xref ref-type="table" rid="T1">Table 1</xref>.</p>
        </sec>
        <sec id="sec11" sec-type="discussion">
            <title>Discussion</title>
            <p>Self-esteem refers to an individual&#x2019;s overall sense of value or worth.
                <sup>
                    <xref ref-type="bibr" rid="ref19">19</xref>
                </sup> Various factors including age,
                <sup>
                    <xref ref-type="bibr" rid="ref21">21</xref>
                </sup> sex,
                <sup>
                    <xref ref-type="bibr" rid="ref22">22</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref23">23</xref>
                </sup> socio-economic status,
                <sup>
                    <xref ref-type="bibr" rid="ref23">23</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref24">24</xref>
                </sup> level of study,
                <sup>
                    <xref ref-type="bibr" rid="ref25">25</xref>
                </sup> academic stress
                <sup>
                    <xref ref-type="bibr" rid="ref12">12</xref>
                </sup> and family environment
                <sup>
                    <xref ref-type="bibr" rid="ref26">26</xref>
                </sup> influence self-esteem. A reasonably high degree of self-esteem is considered an attribute of good mental health,
                <sup>
                    <xref ref-type="bibr" rid="ref27">27</xref>
                </sup> and students with high self-esteem are found to have better academic achievements compared to those with low self-esteem.
                <sup>
                    <xref ref-type="bibr" rid="ref28">28</xref>
                </sup> So, in order to improve the academic performance of medical students, healthy self-esteem is imperative. Moreover, healthcare professionals with high self-esteem show higher tendency to influence and induce positive well-being not only in patients but also in the healthcare team.
                <sup>
                    <xref ref-type="bibr" rid="ref29">29</xref>
                </sup> Empathy is an essential element of the physician-patient relationship and is also an essential quality for medical students.
                <sup>
                    <xref ref-type="bibr" rid="ref30">30</xref>
                </sup> A medical student with low self-esteem is likely to grow less empathetic since self-esteem and empathy are positively correlated.
                <sup>
                    <xref ref-type="bibr" rid="ref30">30</xref>
                </sup> Low self-esteem has also been allied with unhappiness,
                <sup>
                    <xref ref-type="bibr" rid="ref31">31</xref>
                </sup> suicidal ideation,
                <sup>
                    <xref ref-type="bibr" rid="ref32">32</xref>
                </sup> isolation and avoidance of social settings
                <sup>
                    <xref ref-type="bibr" rid="ref33">33</xref>
                </sup> and psychological disorders.
                <sup>
                    <xref ref-type="bibr" rid="ref34">34</xref>
                </sup>
            </p>
            <p>Numerous studies have been conducted on self-esteem among the general population but there have been limited studies conducted among medical students. According to studies carried out by Syed, 
                <italic toggle="yes">et al</italic>. and Nair, 
                <italic toggle="yes">et al</italic>. among medical students, the prevalence of low self-esteem was found to be 18%
                <sup>
                    <xref ref-type="bibr" rid="ref15">15</xref>
                </sup> and 19.4%
                <sup>
                    <xref ref-type="bibr" rid="ref35">35</xref>
                </sup> respectively. According to our study, the prevalence of low self-esteem among the medical students of NAIHS-COM was found to be 18.9% which was similar to the above&#x00a0;mentioned studies. This prevalence of low self-esteem may be due to high academic stress,
                <sup>
                    <xref ref-type="bibr" rid="ref12">12</xref>
                </sup> low perceived family support
                <sup>
                    <xref ref-type="bibr" rid="ref12">12</xref>
                </sup> and learning environment.
                <sup>
                    <xref ref-type="bibr" rid="ref24">24</xref>
                </sup> Since not many studies have been conducted on self-esteem among medical students in Nepal, other contributing factors are yet to be explored. 74.4% of the students had normal levels of self-esteem. Having high but realistic self-esteem is important for sound mental health. But considering the potential for subjective bias in this study, it cannot be implied that the high scores (&gt;25) attained by the respondents are an accurate reflection of their actual self-esteem status, and not a subjective, narcissistic trait. Narcissistic people are self-centered people who do not care much about others. The prevalence of high self-esteem was reported to be 6.7% in our study. Studies among Arab participants suggest that self-esteem positively and significantly linked with attitude towards life, mental health, and general satisfaction.
                <sup>
                    <xref ref-type="bibr" rid="ref36">36</xref>
                </sup>
                <sup>-</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref41">41</xref>
                </sup> People with high self-esteem are expected to persist in the face of challenges than those with low self-esteem.
                <sup>
                    <xref ref-type="bibr" rid="ref42">42</xref>
                </sup> But it is also suggested that people with high self-esteem are more likely to be conceited, arrogant and sometimes narcissistic.
                <sup>
                    <xref ref-type="bibr" rid="ref43">43</xref>
                </sup>
            </p>
            <p>The mean RSES score of males was found to be significantly higher at 19.63 &#x00b1; 4.29, whereas females had a score of 18.26 &#x00b1; 3.8. Studies conducted among Malaysian and Indian students showed no significant difference between males and females.
                <sup>
                    <xref ref-type="bibr" rid="ref44">44</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref45">45</xref>
                </sup> A study done among four Arab counties showed Kuwaiti men had a significantly higher mean score than their female peers.
                <sup>
                    <xref ref-type="bibr" rid="ref40">40</xref>
                </sup> A study conducted in Loni, India also showed higher prevalence of low self-esteem in males than females,
                <sup>
                    <xref ref-type="bibr" rid="ref15">15</xref>
                </sup> whereas our study indicated that low self-esteem was more prevalent among females.</p>
            <p>In our study, significant differences between self-esteem were not found among clinical and pre-clinical year students. However, third year medical students had the highest prevalence of low self-esteem. This could be due to lack of adaptation to academic burden while transitioning from pre-clinical phase to clinical phase. A study conducted in India by Syed 
                <italic toggle="yes">et al</italic> had a dissimilar finding that the cohort of first year males had the highest prevalence of low self-esteem.
                <sup>
                    <xref ref-type="bibr" rid="ref15">15</xref>
                </sup> In a study conducted by Naz, 
                <italic toggle="yes">et al</italic>, the highest prevalence of low self-esteem was found in fourth year medical students.
                <sup>
                    <xref ref-type="bibr" rid="ref46">46</xref>
                </sup> As the third year medical students had the highest prevalence of low self-esteem, proper orientation and pre-exposure sessions should be conducted before entering the clinical phase. Psychological counselling should be frequently provided to all medical students, focusing more on the students with low self-esteem. Medical students should also be encouraged to participate in extracurricular activities which may help in boosting their self-esteem. This is because involvement in extracurricular&#x00a0;activities can help students achieve personal identity development and a sense of self-worth
                <sup>
                    <xref ref-type="bibr" rid="ref47">47</xref>
                </sup> which will in turn, add to their self-esteem.</p>
            <p>A Nigerian study showed that self-esteem is positively and significantly correlated with the primary school attended.
                <sup>
                    <xref ref-type="bibr" rid="ref24">24</xref>
                </sup> The self-esteem of medical students who attended private schools was significantly higher than those of public school students.
                <sup>
                    <xref ref-type="bibr" rid="ref24">24</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref48">48</xref>
                </sup> In our study, we tried to figure out whether there was any difference in self-esteem between students who had attended government schools for primary level of schooling and those who had attended private schools. Although we found that a proportionately higher number of students who had acquired primary levels of education through private schools had low self-esteem, the difference was not significant. We propose that this could be because the majority of the students (88.9%) were from private schools and a comparatively higher percentage of low self-esteem was seen among them. But the statistical significance of this difference was not obtained which could have been due to the very low number of students from government schools for the comparison.</p>
            <p>We were also interested to know if the permanent address of students created an impact on their self-esteem since not all parts of Nepal are equally developed and students from some areas may be deprived of opportunities. But we did not find any significant difference in the self-esteem of students from different provinces.</p>
            <p>Self-esteem can be classified as explicit and implicit self-esteem.
                <sup>
                    <xref ref-type="bibr" rid="ref49">49</xref>
                </sup> Explicit self-esteem is presented in the reflective and deliberative evaluations that one makes about oneself, while implicit self-esteem results from responses to self-relevant stimuli and is the function of automatic process.
                <sup>
                    <xref ref-type="bibr" rid="ref50">50</xref>
                </sup> It is found that people with high explicit self-esteem and low implicit self-esteem showed higher levels of narcissism
                <sup>
                    <xref ref-type="bibr" rid="ref49">49</xref>
                </sup> and the self-esteem level measured with RSES is usually the explicit one.
                <sup>
                    <xref ref-type="bibr" rid="ref51">51</xref>
                </sup> So, a self-esteem score of more than 25 cannot always be guaranteed to be healthy since high self-esteem can be relatively secure or defensive.
                <sup>
                    <xref ref-type="bibr" rid="ref49">49</xref>
                </sup> Our study showed that 6.7% students had high self-esteem. The normal range of self-esteem falls within the 16-25 score range which 74.4% of the students come under.</p>
            <p>Healthy self-esteem in healthcare professionals is a personal quality which, when combined with professionalism and accountability, can greatly reinforce patient satisfaction.
                <sup>
                    <xref ref-type="bibr" rid="ref52">52</xref>
                </sup> This is the reason why strengthening medical students&#x2019; self-esteem warrants special consideration from the beginning of their medical studies as early intervention could yield better results.</p>
            <sec id="sec12">
                <title>Strengths and limitations</title>
                <p>The findings of this study contribute evidence to the limited literature on the status of self-esteem in medical undergraduates at a college in Nepal. Our findings provide estimations of our future doctors&#x2019; levels of self-esteem. This would help the policy makers and medical institution to develop interventions that could support those with low self-esteem. The study used well-known standard screening tools i.e. RSES to assess self-esteem and measured its difference among several variables. The RSES has high reliability.
                    <sup>
                        <xref ref-type="bibr" rid="ref19">19</xref>
                    </sup>
                    <sup>,</sup>
                    <sup>
                        <xref ref-type="bibr" rid="ref20">20</xref>
                    </sup> We also calculated Cronbach&#x2019;s alpha for our study sample and the value for it was 0.811 which showed good internal consistency of the instrument for our population as well.</p>
                <p>As the study was conducted among medical students at a single medical college, the results cannot be generalized to the larger populations of the students of other medical colleges of Nepal as well as the general population. Therefore, multi-centric studies on self-esteem should be conducted in order to expand the generalizability of the findings. Likewise, Rosenberg&#x2019;s self-esteem scale only measures general self-esteem neglecting self-esteem in relation to peers, parents and schooling.
                    <sup>
                        <xref ref-type="bibr" rid="ref53">53</xref>
                    </sup> This leads to partial assessment of levels of self-esteem. The participants may have felt pressure to give answers that were socially desirable which could have contributed to response bias. Response bias includes responding to questionnaire items without understanding them and also, providing what they consider to be socially desirable answers. There might also be subjective bias associated with our study as the questionnaire is based on the subjective feelings of the respondents.</p>
            </sec>
        </sec>
        <sec id="sec13" sec-type="conclusion">
            <title>Conclusion</title>
            <p>This study found that the majority of medical students had normal self-esteem. Several factors including age, gender, schooling, and year of study could have an impact upon self-esteem. Further studies on self-esteem should be conducted on larger populations to determine the contributing factors of low self-esteem in medical students. In our study, low self-esteem was most prevalent in third year students which may be due to the transition from pre-clinical to clinical study. Proper counseling and clinical exposure in pre-clinical years may help students to manage this transition more easily. Considering the conducted study and the related studies, we can conclude that self-esteem along with medical knowledge and skills play a great role in shaping future doctors. Hence, it is recommended that essential measures such as clinical exposure in pre-clinical years and proper counseling should be used to enhance the levels of self-esteem and mental health among medical students.</p>
        </sec>
        <sec id="sec35">
            <title>Conflict of interest</title>
            <p>No competing interests were disclosed.</p>
        </sec>
        <sec id="sec36">
            <title>Funding</title>
            <p>The author(s) declared that no grants were involved in supporting this work.</p>
        </sec>
        <sec id="sec14">
            <title>Data availability</title>
            <sec id="sec15">
                <title>Underlying data</title>
                <p>Figshare: &#x2018;Status of self-esteem in medical students of a college in Kathmandu: A descriptive cross sectional study&#x2019;. 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.6084/m9.figshare.15149589">https://doi.org/10.6084/m9.figshare.15149589</ext-link>.
                    <sup>
                        <xref ref-type="bibr" rid="ref18">18</xref>
                    </sup>
                </p>
            </sec>
            <sec id="sec16">
                <title>Extended data</title>
                <p>Figshare: &#x2018;Status of self-esteem in medical students of a college in Kathmandu: A descriptive cross sectional study&#x2019;. 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.6084/m9.figshare.15149589">https://doi.org/10.6084/m9.figshare.15149589</ext-link>.
                    <sup>
                        <xref ref-type="bibr" rid="ref18">18</xref>
                    </sup>
                </p>
                <p>This project contains the following extended data:
                    <list list-type="bullet">
                        <list-item>
                            <label>-</label>
                            <p>Questionnaire (includes consent form)</p>
                        </list-item>
                    </list>
                </p>
            </sec>
            <sec id="sec17">
                <title>Reporting guidelines</title>
                <p>STROBE checklist for &#x2018;Status of self-esteem in medical students of a college in Kathmandu: A descriptive cross sectional study&#x2019;, 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.6084/m9.figshare.15149589">https://doi.org/10.6084/m9.figshare.15149589</ext-link>.
                    <sup>
                        <xref ref-type="bibr" rid="ref18">18</xref>
                    </sup>
                </p>
                <p>Data are available under the terms of the 
                    <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International license</ext-link> (CC-BY 4.0).</p>
            </sec>
        </sec>
    </body>
    <back>
        <ack>
            <title>Acknowledgements</title>
            <p>We would like to thank the students of NAIHS for their participation and the Community Medicine Department, NAIHS for allowing and helping us to conduct this study.</p>
        </ack>
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    </back>
    <sub-article article-type="reviewer-report" id="report134526">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.124413.r134526</article-id>
            <title-group>
                <article-title>Reviewer response for version 2</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Joshi</surname>
                        <given-names>Sunil Kumar</given-names>
                    </name>
                    <xref ref-type="aff" rid="r134526a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-2704-5060</uri>
                </contrib>
                <aff id="r134526a1">
                    <label>1</label>Nepal Injury Research Centre, Department of Community Medicine, Kathmandu Medical College, Kathmandu, Nepal</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>11</day>
                <month>4</month>
                <year>2022</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2022 Joshi SK</copyright-statement>
                <copyright-year>2022</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport134526" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.72824.2"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>After the revision of the manuscript, I accept the submission.</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Partly</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>No</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Yes</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Reviewer Expertise:</p>
            <p>Public health, Occupational health and safety, injury and violence prevention.</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.</p>
        </body>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report123050">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.76429.r123050</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Joshi</surname>
                        <given-names>Sunil Kumar</given-names>
                    </name>
                    <xref ref-type="aff" rid="r123050a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-2704-5060</uri>
                </contrib>
                <aff id="r123050a1">
                    <label>1</label>Nepal Injury Research Centre, Department of Community Medicine, Kathmandu Medical College, Kathmandu, Nepal</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>9</day>
                <month>3</month>
                <year>2022</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2022 Joshi SK</copyright-statement>
                <copyright-year>2022</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport123050" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.72824.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>reject</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>I appreciate the efforts put forward by a group of young students to participate in such a novel study in Nepal. This study on self-esteem has been conducted in a single medical college in Kathmandu.</p>
            <p> </p>
            <p> Here are a few comments from me:</p>
            <p> There is no explanation on the classification of self-esteem and its relation to the RSES scoring in the Introduction section, it comes for the first time in the Methods section.</p>
            <p> Few sentences need to be rephrased or restructured as they are not very clear to me. The manuscript needs to be checked by an English language expert. The authors should elaborate on the technical words mentioned in the text, e.g., narcissism.</p>
            <p> In the pdf format of the manuscript&#x00a0;"Table 1. Socio-demographic characteristics and RSES of the students along with p-value"&#x00a0;comes in the Methods section, it should go to the Results section.</p>
            <p> </p>
            <p> I have some reservations about the sample size calculation. An&#x00a0;estimated rate of population proportion from a study in a rural Indian medical college i.e.18% has been cited to calculate the sample size (ref 15). NAIHS is not a rural medical college, and as it is the first of its kind study in Nepal, I suggest using the population proportion of 50%. It would bring a sample size of approximately 384. I do not support the adjusted sample size calculation for the finite population in this study. As the total number of students in this medical college is 550, the researchers would be easily able to get the required study respondents. So, I suggest the students do recalculate the sample size as I suggested, extend the data collection and reanalyse data and resubmit for publication. This will definitely make the findings more robust. I suggest being considerate in citing the published literature. I think a total of 53 references is a little high for this article.</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Partly</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>No</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Yes</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Reviewer Expertise:</p>
            <p>Public health, Occupational health and safety, injury and violence prevention.</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above.</p>
        </body>
        <sub-article article-type="response" id="comment8053-123050">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Yadav</surname>
                            <given-names>Stuti</given-names>
                        </name>
                        <aff>Nepalese Army Institute Of Health Sciences, Nepal</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>none</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>5</day>
                    <month>4</month>
                    <year>2022</year>
                </pub-date>
            </front-stub>
            <body>
                <p>Thank you for the comments, sir. The manuscript has been changed as per the comments and the table has also been placed in the results section.</p>
            </body>
        </sub-article>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report98205">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.76429.r98205</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Ugwuanyi</surname>
                        <given-names>Christian Sunday</given-names>
                    </name>
                    <xref ref-type="aff" rid="r98205a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0003-2174-3674</uri>
                </contrib>
                <aff id="r98205a1">
                    <label>1</label>Department of Science Education, Faculty of Education, University of Nigeria, Nsukka, Nigeria</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>3</day>
                <month>2</month>
                <year>2022</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2022 Ugwuanyi CS</copyright-statement>
                <copyright-year>2022</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport98205" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.72824.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>The study explored the state of self-esteem among undergraduates at Tribhuvan University in Nepal's medical college. The majority of medical students reported normal self-esteem, according to the findings of a descriptive cross-sectional survey conducted among first- to fifth-year medical students from December 2020 to April 2021. The findings, however, revealed that 18.9% of students showed low self-esteem, with third-year students being the most affected (30.77 percent). The researchers recommended that to help medical students become confident and effective doctors, interventions to improve self-esteem should be implemented. This study was properly conceptualised and documented as an academic paper, but more efforts should be made by the authors to use recent empirical studies to support their line of argument.&#x00a0;The methodology section of the manuscript was properly handled to allow for its replication. In other words, sufficient details of methods and analysis were provided to allow replication by others.&#x00a0;The results were also adequately presented.</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Partly</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Yes</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Yes</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Yes</p>
            <p>Reviewer Expertise:</p>
            <p>Educational research, measurement and evaluation</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report100126">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.76429.r100126</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Mottershead</surname>
                        <given-names>Richard</given-names>
                    </name>
                    <xref ref-type="aff" rid="r100126a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0003-0048-0553</uri>
                </contrib>
                <aff id="r100126a1">
                    <label>1</label>Ras Al Khaimah College of Nursing, RAK Medical and Health Sciences University, Ras Al Khaimah, United Arab Emirates</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>22</day>
                <month>11</month>
                <year>2021</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2021 Mottershead R</copyright-statement>
                <copyright-year>2021</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport100126" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.72824.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>I would like to say thank you for asking me to review this research. I have read the article and have the following comments to make:</p>
            <p> </p>
            <p> This is a generally well-composed paper, which will be of interest to healthcare educators who wish to be aware of issues which may hamper student performance and well-being. The authors appear to have a creditable background and research experience which gives the article credibility and allows for an interesting insight into student mental well-being within Nepal. The paper proposes that female students are are at greater risk of reduced self-esteem and the causality needs now to be ascertained in order reduce further stigma and shame. Comparisons have been made with relevant contemporary research and this allows for a global overview of the topic and how this article fits within the body of evidence.</p>
            <p> </p>
            <p> I think that the article is correct not to generalize and to highlight the subjective nature of assessing se-esteem but no doubt the data will highlight the need to support and the participants may have developed a collective consciousness on the necessity to self-care in order to be effective healthcare practitioners.&#x00a0;</p>
            <p> </p>
            <p> I wish the authors well with their future efforts to support this cohort and in progressing future research and support networks which I am sure will provide long-term benefits to the health and well-being of medical students with results that can be referred to the wider student healthcare field.</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Yes</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Yes</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Yes</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Yes</p>
            <p>Reviewer Expertise:</p>
            <p>I am a qualified researcher and mental health specialist with experience as an educator within higher education in undergraduate and postgraduate programmes across nursing, medical and health and social care provision.</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.</p>
        </body>
    </sub-article>
</article>
