<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN" "http://jats.nlm.nih.gov/publishing/1.2/JATS-journalpublishing1.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="research-article" dtd-version="1.2" xml:lang="en">
    <front>
        <journal-meta>
            <journal-id journal-id-type="pmc">F1000Research</journal-id>
            <journal-title-group>
                <journal-title>F1000Research</journal-title>
            </journal-title-group>
            <issn pub-type="epub">2046-1402</issn>
            <publisher>
                <publisher-name>F1000 Research Limited</publisher-name>
                <publisher-loc>London, UK</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="doi">10.12688/f1000research.51746.2</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Research Article</subject>
                </subj-group>
                <subj-group>
                    <subject>Articles</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Stage 2 Registered Report: Anomalous perception in a Ganzfeld condition - A meta-analysis of more than 40 years investigation</article-title>
                <fn-group content-type="pub-status">
                    <fn>
                        <p>[version 2; peer review: 2 approved with reservations, 1 not approved]</p>
                    </fn>
                </fn-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author" corresp="yes">
                    <name>
                        <surname>Tressoldi</surname>
                        <given-names>Patrizio E.</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Project Administration</role>
                    <role content-type="http://credit.niso.org/">Software</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-6404-0058</uri>
                    <xref ref-type="corresp" rid="c1">a</xref>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Storm</surname>
                        <given-names>Lance</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Project Administration</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="aff" rid="a2">2</xref>
                </contrib>
                <aff id="a1">
                    <label>1</label>Studium Patavinum, University of Padua, Padova, Italy</aff>
                <aff id="a2">
                    <label>2</label>School of Psychology, University of Adelaide, Adelaide, Australia</aff>
            </contrib-group>
            <author-notes>
                <corresp id="c1">
                    <label>a</label>
                    <email xlink:href="mailto:patrizio.tressoldi@unipd.it">patrizio.tressoldi@unipd.it</email>
                </corresp>
                <fn fn-type="conflict">
                    <p>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>9</day>
                <month>2</month>
                <year>2023</year>
            </pub-date>
            <pub-date pub-type="collection">
                <year>2021</year>
            </pub-date>
            <volume>10</volume>
            <elocation-id>234</elocation-id>
            <history>
                <date date-type="accepted">
                    <day>3</day>
                    <month>2</month>
                    <year>2023</year>
                </date>
            </history>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2023 Tressoldi PE and Storm L</copyright-statement>
                <copyright-year>2023</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <self-uri content-type="pdf" xlink:href="https://f1000research.com/articles/10-234/pdf"/>
            <abstract>
                <p>This meta-analysis is an investigation into anomalous perception (i.e., conscious identification of information without any conventional sensorial means). The technique used for eliciting an effect is the ganzfeld condition (a form of sensory homogenization that eliminates distracting peripheral noise). The database consists of studies published between January 1974 and December 2020 inclusive.</p>
                <p> The overall effect size estimated both with a frequentist and a Bayesian random-effect model, were in close agreement yielding an effect size of .088 (.04-.13). This result passed four publication bias tests and seems not contaminated by questionable research practices.</p>
                <p> </p>
                <p> Trend analysis carried out with a cumulative meta-analysis and a meta-regression model with Year of publication as covariate, did not indicate sign of decline of this effect size.</p>
                <p> The moderators analyses show that selected participants outcomes were almost three-times those obtained by non-selected participants and that tasks that simulate telepathic communication show a two-fold effect size with respect to tasks requiring the participants to guess a target.</p>
                <p>The Stage 1 Registered Report can be accessed here: 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.12688/f1000research.24868.3">https://doi.org/10.12688/f1000research.24868.3</ext-link>
                </p>
            </abstract>
            <kwd-group kwd-group-type="author">
                <kwd>Rgistered Report</kwd>
                <kwd>meta-analysis</kwd>
                <kwd>ganzfeld</kwd>
                <kwd>anomalous perception</kwd>
            </kwd-group>
            <funding-group>
                <funding-statement>The author(s) declared that no grants were involved in supporting this work.</funding-statement>
            </funding-group>
        </article-meta>
        <notes>
            <sec sec-type="version-changes">
                <label>Revised</label>
                <title>Amendments from Version 1</title>
                <p>We added the standardized effect size formula used. We updated all statistical analyses accordingly.</p>
            </sec>
        </notes>
    </front>
    <body>
        <sec id="sec1" sec-type="intro">
            <title>Introduction</title>
            <p>The possibility of identifying pictures or video clips without conventional (sensorial) means, in a ganzfeld environment, is a decades old controversy, dating back to the pioneering investigation of Charles Honorton, William Braud and Adrian Parker between 1974 and 1975 (
                <xref ref-type="bibr" rid="ref26">Parker, 2017</xref>).</p>
            <p>In the ganzfeld, a German term meaning &#x2018;whole field&#x2019;, participants are immersed in an homogeneous sensorial field were peripheral visual information is masked out by red light diffused by translucent hemispheres (often split halves of ping-pong balls or special glasses) placed over the eyes, while a relaxing rhythmic sound, or white or pink noise, is fed through headphones to shield out peripheral auditory information. Once participants are sensorially isolated from external visual and auditory stimulation, they are in a favorable condition for producing inner mental contents about a randomly-selected target hidden amongst decoys. The mentation they produce can either be used by the participant to guide his/her target selection, or it can be used to assist in an independent judging process.</p>
            <p>In the prototypical procedure, participants are tested in a room isolated from external sounds and visual information. After they make themselves comfortable in a reclining armchair, they receive instructions related to their task during the ganzfeld condition. Even if there are different verbatim versions, the instructions describe what they should do mentally in order to detect the information related to the target and how to filter out the mental contents not related to it. This information will be described aloud and recorded for playback before or during the target identification phase. After the relaxation phase, which can range from 5 to 15 minutes, they are exposed to the ganzfeld condition for a period ranging from 15 to 30 minutes. During this phase, participants describe verbally all images, feelings, emotions, they deem related to the target usually a picture or a short video-clip of real objects or events.</p>
            <p>Once the ganzfeld phase is completed, participants are presented with different choices (e.g., the target plus three decoys) of the same format, e.g., picture or videoclip, and they must choose which one is the target (binary decision). Alternatively, they may be asked to rate all four (e.g., from 0 to 100), to indicate the strength of relationship between the information detected during the ganzfeld phase and the images or video clips contents.</p>
            <p>A variant of the judgment phase is to send the recording of the information retrieved during the ganzfeld phase to an external judge for independent ratings of the target. In order to prevent voluntary or involuntary leakage of information about the target by the experimenters, the research assistant who interacts with the participants must be blind to the target identity until the participants&#x2019; rating task is over.</p>
            <p>The choice of the target and the decoys is usually made using automatic random procedures, and scores are automatically fed onto a scoring sheet.</p>
            <p>There are three different ganzfeld conditions:
                <list list-type="bullet">
                    <list-item>
                        <label>&#x2022;</label>
                        <p>Type 1: the target is chosen after the judgment phase;</p>
                    </list-item>
                    <list-item>
                        <label>&#x2022;</label>
                        <p>Type 2: the target is chosen before the ganzfeld phase;</p>
                    </list-item>
                    <list-item>
                        <label>&#x2022;</label>
                        <p>Type 3: the target is chosen before the ganzfeld phase and presented to a partner of the participant isolated in a separate and distant room. From an historical perspective, this last type is considered the typical condition.</p>
                    </list-item>
                </list>
            </p>
            <p>These differences are related to some theoretical and perceptual concepts we will discuss later. It is important to note that type of task makes no difference to the participant who only engages in target identification 
                <italic toggle="yes">after</italic> the ganzfeld phase.</p>
            <sec id="sec2">
                <title>Review of the Ganzfeld Meta-Analyses</title>
                <p>It is interesting to note that most of the cumulative findings (meta-analyses) of this line of investigation were periodically published in the mainstream journal 
                    <italic toggle="yes">Psychological Bulletin.</italic>
                </p>
                <p>
                    <xref ref-type="bibr" rid="ref17">Honorton (1985)</xref> undertook one of the first meta-analyses of the many ganzfeld studies completed by the mid-1980s. In total, 28 studies yielded a collective hit rate (correct identification) of 38%, where mean chance expectation (MCE) was 25%. Various flaws in his approach were pointed out by 
                    <xref ref-type="bibr" rid="ref15">Hyman (1985)</xref>, but in their joint-communiqu&#x00e9; they agree that &#x201c;there is an overall significant effect in this database that cannot reasonably be explained by selective reporting or multiple analysis&#x201d; (
                    <xref ref-type="bibr" rid="ref16">Hyman &amp; Honorton, 1986</xref>, p. 351).</p>
                <p>A second major meta-analysis on a set of &#x2018;autoganzfeld&#x2019; studies was performed by 
                    <xref ref-type="bibr" rid="ref4">Bem &amp; Honorton (1994)</xref>. These studies followed the guidelines laid down by 
                    <xref ref-type="bibr" rid="ref16">Hyman &amp; Honorton (1986)</xref>. Moreover the autoganzfeld procedure avoids methodological flaws by using a computer-controlled target randomization, selection, and judging technique. They overall reported hit rate of 32.2% exceeded again the mean chance expectation.</p>
                <p>
                    <xref ref-type="bibr" rid="ref24">Milton &amp; Wiseman (1999)</xref> meta-analysed further 30 studies collected for the period 1987 to 1997; reporting an overall nonsignificant standardized effect size of 0.013. However, Jessica Utts (personal communication, December 11, 2009) using the exact binomial test on trial counts only (
                    <italic toggle="yes">N</italic> = 1198; Hits = 327), found a significant hit rate of 27% (
                    <italic toggle="yes">p</italic> = 0.036).</p>
                <p>
                    <xref ref-type="bibr" rid="ref31">Storm &amp; Ertel (2001)</xref> comparing 
                    <xref ref-type="bibr" rid="ref24">Milton &amp; Wiseman&#x2019;s (1999)</xref> database with 
                    <xref ref-type="bibr" rid="ref4">Bem &amp; Honorton&#x2019;s (1994)</xref> one, found the two did not differ significantly. Furthermore Storm and Ertel went on to compile a 79-study database, which had a statistically significant average standardized effect size of 0.138.</p>
                <p>
                    <xref ref-type="bibr" rid="ref32">Storm 
                        <italic toggle="yes">et al.</italic> (2010)</xref>, meta-analysed a database of 29 ganzfeld studies published during the period 1997 to 2008, yielding an average standardized effect size of 0.14. 
                    <xref ref-type="bibr" rid="ref28">Rouder 
                        <italic toggle="yes">et al.</italic> (2013)</xref> reassessing 
                    <xref ref-type="bibr" rid="ref32">Storm 
                        <italic toggle="yes">et al.</italic>&#x2019;s (2010)</xref> meta-analysis with a Bayesian approach, found evidence for the existence of an anomalous perception in the original dataset observing a Bayes Factor of 330 in support of the alternative hypothesis (p. 241). However they contended the effect could be due to &#x201c;difficulties in randomization&#x201d; (p. 241), arguing that ganzfeld studies with computerized randomization had smaller effects than those with manual randomization. The reanalysis by 
                    <xref ref-type="bibr" rid="ref33">Storm 
                        <italic toggle="yes">et al.</italic>&#x2019;s (2013)</xref> showed that this conclusion was unconvincing as it was based on Rouder 
                    <italic toggle="yes">et al.</italic>&#x2019;s faulty inclusion of different categories of study.</p>
                <p>In the last meta-analysis by 
                    <xref ref-type="bibr" rid="ref34">Storm &amp; Tressoldi (2020)</xref>, related to the studies published from 2008 to 2018, the overall standardized effect size was 0.133; 95%CI: 0.06-0.18.</p>
            </sec>
            <sec id="sec3">
                <title>This study</title>
                <p>The main aim of this study is to meta-analyse all available ganzfeld studies dating from 1974 up to December 2020 in order to assess the average effect size of the database with the more advanced statistical procedures that should overcome the limitations of the previous meta-analyses. Furthermore, we aim to identify whether there are moderator variables that affect task performance. In particular, we hypothesize that participant type and type of task are two major moderators of effect size (see Methods section).</p>
            </sec>
        </sec>
        <sec id="sec4" sec-type="methods">
            <title>Methods</title>
            <sec id="sec5">
                <title>Reporting guidelines</title>
                <p>This study follows the guidelines of the APA Meta-Analysis Reporting Standard (
                    <xref ref-type="bibr" rid="ref1">Appelbaum 
                        <italic toggle="yes">et al.</italic>, 2018</xref>) and the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (
                    <xref ref-type="bibr" rid="ref25">PRISMA-P, Moher 
                        <italic toggle="yes">et al.</italic>, 2015</xref>).</p>
                <p>All following analyses have been approved in the Stage 1 (
                    <xref ref-type="bibr" rid="ref35">Tressoldi &amp; Storm, 2021</xref>). Supplementary and new analyses not approved in the Stage 1, are reported in the 
                    <italic toggle="yes">Exploratory analyses</italic> section in the Results.</p>
            </sec>
            <sec id="sec6">
                <title>Studies retrieval</title>
                <p>Retrieval of studies related to anomalous perception in a Ganzfeld environment is simplified, firstly by the fact that most of these studies have already been retrieved for previous meta-analyses, as cited in the introduction. Secondly, this line of investigation is carried out by a small community of researchers. Thirdly, most of the studies of interest to us are published in specialized journals that adopted the editorial policy of accepting paper with results that are statistically non-significant (according to the frequentist approach). This last condition is particularly relevant because it reduces the publication bias due to non-publication (file drawer effect) of studies with statistically non-significant results often as a consequence of reduced statistical power.</p>
                <p>Furthermore in order to integrate the previous retrieval method, we carried-out an online search with 
                    <ext-link ext-link-type="uri" xlink:href="https://scholar.google.com/">Google Scholar</ext-link>, 
                    <ext-link ext-link-type="uri" xlink:href="https://pubmed.ncbi.nlm.nih.gov/">PubMed</ext-link> and 
                    <ext-link ext-link-type="uri" xlink:href="https://www.scopus.com/home.uri">Scopus</ext-link> databases of all papers from 1974 to 2020 including in the title and/or the abstract the word &#x201c;ganzfeld&#x201d; (e.g., for PubMed: Search: ganzfeld [Title/Abstract] Filters: from 1974 &#x2013; 2020).</p>
            </sec>
            <sec id="sec7">
                <title>Studies inclusion criteria</title>
                <p>The following inclusion criteria were adopted:
                    <list list-type="bullet">
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Studies related to anomalous perception in a ganzfeld environment;</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Studies must use human participants only (not animals);</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Number of participants must be in excess of two to avoid the inherent problems that are typical in case studies;</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Target selection must be randomized by using a Random Number Generator (RNG) in a computer or similar electronic device, or a table of random numbers.</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Randomization procedures must not be manipulated by the experimenter or participant;</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Studies must provide sufficient information (e.g., number of trials and outcomes) for the authors to calculate the direct hit-rates and effect size values, so that appropriate statistical tests can be conducted.</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Peer reviewed and not peer-reviewed studies e.g. published in proceedings excluding dissertations.</p>
                        </list-item>
                    </list>
                </p>
            </sec>
            <sec id="sec8">
                <title>Variables coding</title>
                <p>For each included study, one of the authors, expert in meta-analyses, coded the following variables:
                    <list list-type="bullet">
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Authors;</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Year of publication;</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Number of trials;</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Number of hits;</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Number of choices of each trial;</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Task type (Type 1,2 or 3);</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Participants type (selected vs. unselected). The authors of the study scored as &#x2018;selected&#x2019; all participants that were screened for one or more particular characteristic deemed favourable for the performance in this type of task. All others were coded as &#x2018;non-selected&#x2019;</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Peer-Review level: Level = 1 for studies published in conference proceedings and 
                                <italic toggle="yes">Researches In Parapsychology</italic> (moderate peer-review); Level = 2, for the studies published in scientific journals with full peer-review.</p>
                        </list-item>
                    </list>
                </p>
                <p>The second author randomly checked all studies, and the data was compared with those extracted by the other author. Discrepancies were corrected by inspecting the original papers.</p>
                <p>The complete database with all supporting information is available as 
                    <italic toggle="yes">Underlying data</italic> (
                    <xref ref-type="bibr" rid="ref36">Tressoldi &amp; Storm, 2020</xref>).</p>
            </sec>
            <sec id="sec9">
                <title>Effect size measures</title>
                <p>As standardized measure of effect size, we used that one applied in 
                    <xref ref-type="bibr" rid="ref32">Storm, Tressoldi &amp; Di Risio (2010)</xref> and 
                    <xref ref-type="bibr" rid="ref34">Storm &amp; Tressoldi (2020)</xref>: Binomial Z score/&#x221a;number of trials using the number of trials, the hits score and the chance probability as raw scores. The exact binomial Z score has been obtained applying the formula implemented online at 
                    <ext-link ext-link-type="uri" xlink:href="http://vassarstats.net/binomialX.html">http://vassarstats.net/binomialX.html</ext-link>. When this algorithm did not compute the 
                    <italic toggle="yes">z</italic> value when either number of trials or number of hits were low, we used the one-tailed exact binomial 
                    <italic toggle="yes">p</italic>-value, to find the inverse normal 
                    <italic toggle="yes">z</italic> by using the online app at 
                    <ext-link ext-link-type="uri" xlink:href="http://www.fourmilab.ch/rpkp/experiments/analysis/zCalc.html">http://www.fourmilab.ch/rpkp/experiments/analysis/zCalc.html</ext-link> where the formula of this conversion is described.</p>
                <p>The standardized effect size was computed applying the formula Z/&#x221a;N of participants.</p>
                <p>As standard error, we used the formula: &#x221a;(hit rate % * (1-hit rate %)/participants * chance percentage *(1-chance percentage)).</p>
                <p>In order to take into account the effect size overestimation bias in small samples, the effect sizes and their standard errors, were transformed in the Hedge&#x2019;s 
                    <italic toggle="yes">g</italic> effect sizes, with the corresponding standard errors by applying the formula presented in 
                    <xref ref-type="bibr" rid="ref6">Borenstein 
                        <italic toggle="yes">et al.</italic> (2009</xref>, pp. 27&#x2013;28: g = (1-(3/(4df-1)))* d)).</p>
            </sec>
            <sec id="sec10">
                <title>Pooled estimate of the average effect</title>
                <p>In order to account for the between-studies heterogeneity, the overall effect size estimation of the whole database has been calculated by applying both a frequentist and a Bayesian random-effect model for testing its robustness.</p>
            </sec>
            <sec id="sec11">
                <title>Frequentist random-effect model</title>
                <p>Following the recommendations of 
                    <xref ref-type="bibr" rid="ref22">Langan 
                        <italic toggle="yes">et al.</italic> (2019)</xref>, we used the restricted maximum likelihood (REML) approach to estimate the heterogeneity variance with the Knapp and Hartung method for adjustment to the standard errors of the estimated coefficients (
                    <xref ref-type="bibr" rid="ref29">Rubio-Aparicio 
                        <italic toggle="yes">et al.</italic>, 2018</xref>).</p>
                <p>Furthermore, in order to control for possible influence of outliers, we calculated the median and mode of the overall effect size applying the method suggested by 
                    <xref ref-type="bibr" rid="ref12">Hartwig 
                        <italic toggle="yes">et al.</italic> (2020)</xref>.</p>
                <p>These calculations were implemented in the 
                    <ext-link ext-link-type="uri" xlink:href="https://www.r-project.org/">R</ext-link> statistical environment v.4.0.3 with the 
                    <ext-link ext-link-type="uri" xlink:href="https://cran.r-project.org/web/packages/metafor/index.html">metafor</ext-link> package v. 2.4 (
                    <xref ref-type="bibr" rid="ref38">Viechtbauer, 2017</xref>). See syntax details provided as extended data (
                    <xref ref-type="bibr" rid="ref36">Tressoldi &amp; Storm, 2020</xref>).</p>
            </sec>
            <sec id="sec12">
                <title>Bayesian random-effect model</title>
                <p>As priors for the average effect size we used a normal distribution with Mean = 0.1; 
                    <italic toggle="yes">SD</italic> = 0.03, constrained positive, lower bound = 0 (
                    <xref ref-type="bibr" rid="ref11">Haaf &amp; Rouder, 2020</xref>), given our expectation of a positive value. As prior for the tau parameter we used an inverse gamma distribution with shape = 1, scale = 0.15.</p>
                <p>This Bayesian meta-analysis was conducted using the 
                    <ext-link ext-link-type="uri" xlink:href="https://cran.r-project.org/web/packages/metaBMA/index.html">MetaBMA</ext-link> package v. 0.6.7 (
                    <xref ref-type="bibr" rid="ref13">Heck 
                        <italic toggle="yes">et al.</italic>, 2017</xref>).</p>
            </sec>
            <sec id="sec13">
                <title>Publication bias tests</title>
                <p>Following the suggestions of 
                    <xref ref-type="bibr" rid="ref8">Carter 
                        <italic toggle="yes">et al.</italic> (2019)</xref>, we applied four tests to assess publication bias:
                    <list list-type="bullet">
                        <list-item>
                            <label>&#x2022;</label>
                            <p>the 3-parameter selection model (3PSM), as implemented by 
                                <xref ref-type="bibr" rid="ref9">Coburn &amp; Vevea (2019)</xref> with the package &#x2018;
                                <ext-link ext-link-type="uri" xlink:href="https://cran.r-project.org/web/packages/weightr/index.html">weightr</ext-link>&#x2019; v.2.0.2;</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>the p-uniform* (star) v. 0.2.5 test as described by 
                                <xref ref-type="bibr" rid="ref37">van Aert &amp; van Assen (2019)</xref>, and</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>the sensitivity analysis using the 
                                <xref ref-type="bibr" rid="ref23">Mathur &amp; VanderWeele (2020)</xref> package 
                                <ext-link ext-link-type="uri" xlink:href="https://cran.r-project.org/web/packages/PublicationBias/index.html">PublicationBias</ext-link> v.2.3.0.</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>The Robust Bayesian meta-analysis test implemented with the RoBMA package v.2.3.1 (
                                <xref ref-type="bibr" rid="ref2">Barto&#x0161; &amp; Maier, 2020</xref>).</p>
                        </list-item>
                    </list>
                </p>
                <p>The three parameters model represents the average true underlying effect, 
                    <italic toggle="yes">&#x03b4;</italic>, the heterogeneity of the random effect sizes, &#x03c4; 
                    <sup>2</sup> and the probability that there is a nonsignificant effect in the pool of effect sizes. The probability parameter is modelled by a step function with a single cut point at 
                    <italic toggle="yes">p</italic> = 0.025 (one-tailed), which corresponds to a two-tailed 
                    <italic toggle="yes">p</italic> value of 0.05. This cut point divides the range of possible 
                    <italic toggle="yes">p</italic> values into two bins: significant and nonsignificant. The three parameters are estimated using maximum likelihood (
                    <xref ref-type="bibr" rid="ref8">Carter 
                        <italic toggle="yes">et al.</italic>, 2019</xref>, p. 124).</p>
                <p>The 
                    <italic toggle="yes">p</italic>-uniform* test, is an extension and improvement of the 
                    <italic toggle="yes">p</italic>-uniform method. P-uniform* improves upon 
                    <italic toggle="yes">p</italic>-uniform giving a more efficient estimator avoiding the overestimation of effect size in case of between-study variance in true effect sizes, thus enabling estimation and testing for the presence of between-study variance in true effect sizes.</p>
                <p>Sensitivity analysis, as implemented by 
                    <xref ref-type="bibr" rid="ref23">Mathur &amp; VanderWeele (2020)</xref>, assumes a publication process such that &#x201c;statistically significant&#x201d; results are more likely to be published than negative or &#x201c;nonsignificant&#x201d; results by an unknown ratio, 
                    <italic toggle="yes">&#x03b7;</italic> (eta). Using inverse-probability weighting and robust estimation that accommodates non-normal true effects, small meta-analyses and clustering, it enables statements such as: &#x201c;For publication bias to shift the observed point estimate to the null, &#x2018;significant&#x2019; results would need to be at least 30-fold more likely to be published than negative or &#x2018;non-significant&#x2019; results&#x201d; (p. 1). Comparable statements can be made regarding shifting to a chosen non-null value or shifting the confidence interval.</p>
                <p>The Robust Bayesian meta-analysis test is an extension of Bayesian meta-analysis obtained by adding selection models to account for publication bias. This allows model-averaging across a larger set of models, ones that assume publication bias and ones that do not. This test allows us to quantify evidence for the absence of publication bias estimated with a Bayes Factor. In our case we compared only two models, a random-effect model assuming no publication bias and a random-model assuming publication bias.</p>
            </sec>
            <sec id="sec14">
                <title>Cumulative meta-analysis</title>
                <p>In order to ascertain the overall trend of the cumulative evidence and in particular for testing the presence of a positive or negative trend effect, we performed a cumulative effect size estimation.</p>
            </sec>
            <sec id="sec914">
                <title>Meta-regression</title>
                <p>Furthermore, we estimated the overall effect size taking the variable &#x201c;year of publication&#x201d; as covariate using a meta-regression model.</p>
            </sec>
            <sec id="sec15">
                <title>Moderators effects</title>
                <p>We compared the influence of the following tree moderators: (i) Type of participant, (ii) Type of task and (iii) Level of peer-review.</p>
                <p>As described in the Variable Coding paragraph, the variable Type of participant, has been coded in a binary way: selected vs unselected. Type of task has been coded as Type 1, Type 2, and Type 3, as described in the Introduction and level of Peer-review as 1 for studies published in conference proceedings or 2, for the studies published in scientific journals with full peer-review.</p>
            </sec>
            <sec id="sec16">
                <title>Statistical power</title>
                <p>The overall statistical power was estimated using R package metameta v.0.1.1. (
                    <xref ref-type="bibr" rid="ref27">Quintana, 2020</xref>). Furthermore, we calculated the number of trials necessary to achieve a statistical power of at least.80 with an &#x03b1; = .05. With this estimation we examined how many studies in the database reached this threshold.</p>
            </sec>
        </sec>
        <sec id="sec17" sec-type="results">
            <title>Results</title>
            <p>The search and selection of the studies is presented in the PRISMA flowchart in 
                <xref ref-type="fig" rid="f1">Figure 1</xref>. As shown in the flowchart, our final database comprises 78 studies, for a total of 113 effect sizes carried out by 46 different principal investigators.</p>
            <fig fig-type="figure" id="f1" orientation="portrait" position="float">
                <label>Figure 1. </label>
                <caption>
                    <title>PRISMA flowchart.</title>
                </caption>
                <graphic orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/143962/d69a9c00-73fd-498f-b359-5dcfe1450fb9_figure1.gif"/>
            </fig>
            <p>The list of all references related to the included and excluded studies is available in the GZMAReference List file and the data used for all the following statistical analyses is available in the GZMADatabase1974_2020 file in the 
                <italic toggle="yes">Underlying data</italic> (
                <xref ref-type="bibr" rid="ref36">Tressoldi &amp; Storm, 2020</xref>).</p>
            <sec id="sec18">
                <title>Descriptive statistics</title>
                <p>Descriptive statistics related to the variables trials, hits rate, participants type, task types, peer-review level are presented in 
                    <xref ref-type="table" rid="T1">Table 1</xref>.</p>
                <table-wrap id="T1" orientation="portrait" position="float">
                    <label>Table 1. </label>
                    <caption>
                        <title>Descriptive statistics of the main variables.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top"/>
                                <th align="left" colspan="1" rowspan="1" valign="top">Trials</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Hits rate</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Task Type</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Participants Type</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Peer-review level</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Mean (
                                    <italic toggle="yes">SD</italic>)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">42.8 (27.2)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">.32 (.11)
                                    <xref ref-type="table-fn" rid="tfn1">*</xref>
                                </td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Range</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4-138</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0-60</td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Count (%)</td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td align="left" colspan="1" rowspan="1" valign="top">Type 1: 5 (4.2)
                                    <break/>Type 2: 27 (23.8)
                                    <break/>Type 3: 81 (72)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Non-selected: 70 (62)
                                    <break/>Selected: 43
                                    <break/>(38)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Level 1: 47 (41.6)
                                    <break/>Level 2: 66 (58.4)</td>
                            </tr>
                        </tbody>
                    </table>
                    <table-wrap-foot>
                        <fn id="tfn1">
                            <label>*</label>
                            <p>= this value is purely descriptive because not all studies are 4 free-choice designs.</p>
                        </fn>
                    </table-wrap-foot>
                </table-wrap>
                <p>
                    <italic toggle="yes">Comment:</italic> The range of the number of trials as well as the hits percentage is quite wide. The number of task types show that the main types are Type 2: the target is chosen before the ganzfeld phase) and of Type 3: the target is chosen before the ganzfeld phase and presented to a partner of the participant isolated in a separate and distant room. Type 1 studies (target randomly selected after participant makes a choice) are only 5 (4.2%).</p>
                <p>The percentage of studies using non-selected participants is greater (62% vs 38%) than that of studies using selected. Most studies (58.4%) were peer-reviewed.</p>
            </sec>
            <sec id="sec19">
                <title>Pooled estimate of the average effect</title>
                <p>The estimate of the average effect along with the corresponding 95% Confidence Intervals or Credible Intervals of both the frequentist and the Bayesian random-effect models as described in the Methods section, and values of &#x03c4;
                    <sup>2</sup> and I
                    <sup>2</sup> (
                    <xref ref-type="bibr" rid="ref14">Higgins &amp; Thompson, 2002</xref>) with their confidence intervals, as measures of between-study variance, are presented in 
                    <xref ref-type="table" rid="T2">Table 2</xref>.</p>
                <table-wrap id="T2" orientation="portrait" position="float">
                    <label>Table 2. </label>
                    <caption>
                        <title>Frequentist and Bayesian random-effect model results effect size.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top"/>
                                <th align="left" colspan="1" rowspan="1" valign="top">Frequentist weighted ES (95% Confidence Intervals)</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Bayesian weighted ES
                                    <break/>(95% Credible Intervals)</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">&#x03c4;
                                    <sup>2</sup>
                                    <break/>(95% Confidence Intervals)</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">I
                                    <sup>2</sup>
                                    <break/>(95% Confidence Intervals)</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Mean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">.099 (.05 - .14)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">.10 (.06 - .13)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">.04 (.02 - .06)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">68.7 (58.9 - 76.5)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">P value or Bayes Factor
                                    <sub>(H1/H0)</sub>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2.35
                                    <sup>e-5</sup>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1909</td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <p>
                    <italic toggle="yes">Comment:</italic> The frequentist and the Bayesian random-effect model parameters estimations are in close agreement, and both reject the null (H0) hypothesis with a high probability.</p>
                <p>In terms of hits percentage above chance, this small effect size corresponds to 3.8% (95%CIs: 1.7 &#x2013; 5.9).</p>
                <p>The level of heterogeneity is medium-large as expected by the influence of the moderators. Given this heterogeneity level, the values of the effect size median = .017 (-.025 - .06) and mode -.01 (-.13 - .10), are uninformative.</p>
                <p>The forest plot is available as Figure S1 (
                    <italic toggle="yes">Extended data</italic> (
                    <xref ref-type="bibr" rid="ref36">Tressoldi &amp; Storm, 2020</xref>)).</p>
            </sec>
            <sec id="sec20">
                <title>Outliers detection and influence</title>
                <p>In order to detect the presence of influential outliers, we applied the &#x201c;influence&#x201d; function in the metafor package. These procedures identified two influential outliers. The results of the frequentist random-effect model without the influential outliers, are very similar to those with the outliers (mean ES: .099; 95% CIs: .05 - .14).</p>
            </sec>
            <sec id="sec21">
                <title>Cumulative effect size</title>
                <p>The results of the cumulative meta-analysis is represented with a cumulative forest plot in Figure S2 (
                    <italic toggle="yes">Extended data</italic> (
                    <xref ref-type="bibr" rid="ref36">Tressoldi &amp; Storm, 2020</xref>)). From the inspection of the cumulative forest plot, it emerges that the overall effect size stabilized around the cumulative evidence obtained up to 1997. Thus, it appears to be stable for more than 20 years.</p>
            </sec>
            <sec id="sec22">
                <title>Meta-regression</title>
                <p>The results of the meta-regression with &#x201c;Year&#x201d; as covariate, show a slope estimate of -.0012 (95%CIs: -.005 - .003; 
                    <italic toggle="yes">p</italic> = .57).</p>
                <p>
                    <italic toggle="yes">Comment:</italic> These results support the hypothesis that the overall effect size is not affected by the year of publication of the experiments.</p>
                <p>
                    <italic toggle="yes">
                        <bold>Exploratory analyses</bold>
                    </italic>
                </p>
                <p>Another way to observe the cumulative trend of the overall effect size, is to examine the evolution of the Bayes Factor and of Posterior Probability of H1 as the data accumulate. This information has been obtained using the option &#x201c;sequential Bayes Factor&#x201d; and &#x201c;sequential posterior model probability&#x201d; within the module Bayesian Meta-Analysis in the software JASP v.0.17.0 (
                    <xref ref-type="bibr" rid="ref18">Jasp, 2020</xref>) that are presented in Figures S3 and S4 (
                    <italic toggle="yes">Extended data</italic> (
                    <xref ref-type="bibr" rid="ref36">Tressoldi &amp; Storm, 2020</xref>)). From these two plots it is possible to observe how the Bayes Factor started a positive linear trend after approximately 70 experiments. The maximum Posterior probability is achieved after approximately 80 experiments. The JASP file is available as 
                    <italic toggle="yes">Underlying data</italic> (
                    <xref ref-type="bibr" rid="ref36">Tressoldi &amp; Storm, 2020</xref>).</p>
            </sec>
            <sec id="sec23">
                <title>Publication Bias tests</title>
                <p>The results of the four publication bias tests described in the Methods section are presented in 
                    <xref ref-type="table" rid="T3">Table 3</xref> and in the information that follows.</p>
                <table-wrap id="T3" orientation="portrait" position="float">
                    <label>Table 3. </label>
                    <caption>
                        <title>Results of the p-uniform* and the 3-parameter selection model (3PSM), publication bias tests.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top"/>
                                <th align="left" colspan="1" rowspan="1" valign="top">p-uniform*</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">3PSM</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">RoBMA</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">ES</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">.18</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">.15</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">.098</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">95% CIs</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">.10 - .26</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">.06 - .23</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">.04 - .14</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <p>The results of the sensitivity analysis publication bias to shift the observed effect size point estimate to the.01 level, considered the smallest effect size of interest, indicated that no amount of publication bias (parameter eta) under the assumed model would suffice to shift the point estimate to this level.</p>
                <p>
                    <italic toggle="yes">
                        <bold>Comment</bold>:</italic> The overall effect size estimate passes all four publication bias tests.</p>
            </sec>
            <sec id="sec24">
                <title>Moderators analyses</title>
                <p>The weighted effect size along with the corresponding 95% confidence Intervals of the two types of participants, the three task types and the two peer-review level, are presented in 
                    <xref ref-type="table" rid="T4">Table 4</xref>.</p>
                <table-wrap id="T4" orientation="portrait" position="float">
                    <label>Table 4. </label>
                    <caption>
                        <title>Effect sizes and 95% CIs related to the moderators&#x2019; categories.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top"/>
                                <th align="left" colspan="1" rowspan="1" valign="top">Selected Participants</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Non-selected participants</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Task Type 1</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Task Type 2</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Task Type 3</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Peer-review level 1</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Peer-review level 2</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">ES</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">.17</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">.05</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">.13</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">.04</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">.11</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">.09</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">.10</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">95% CIs</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">.09 - .24</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-.006 - .11</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-.09 - .35</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-.04 - .14</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">.05 - .17</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">.01 - .16</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">.04 - .16</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
            </sec>
            <sec id="sec25">
                <title>Exploratory analysis</title>
                <p>After looking at the participants selection and Task Type results, it was interesting to learn that selected participants and Task Type 3 combined, gave: 
                    <italic toggle="yes">ES</italic> = .18; 95%CIs: .07 - .29; not different from the results obtained by the selected participants in all three types of tasks.</p>
                <p>
                    <italic toggle="yes">Comment</italic>: Whereas it is clear that the levels of peer-review did not yield differences in the effect sizes, the selection of participants and the Task Types show substantial and statistically significant differences.</p>
                <p>Selected participants show a three-fold increase in the effect size with respect to the non-selected participants. In terms of hits percentage above chance, this difference corresponds to 7.6%; 95%CI: 3-12 and 1%; 95%CI: -1 &#x2013; 4.7, respectively.</p>
                <p>Similarly, Tasks Type 1 and 3 show more than two-fold increase in ES compared to Type 2 tasks. The effect size observed with tasks Type 1, must be considered with caution given the low number of experiments (5).</p>
            </sec>
            <sec id="sec26">
                <title>Statistical power</title>
                <p>The median statistical power related to the observed overall effect size is&#x00a0;.106. This result explains the fact that only 21 (18.5%) of the studies reported statistically significant results.</p>
            </sec>
        </sec>
        <sec id="sec27" sec-type="discussion">
            <title>Discussion</title>
            <p>The main aim of this meta-analysis was to get an overall picture of the evidence accumulated in more than 40 years of investigation related to an anomalous perception in a ganzfeld environment.</p>
            <p>The estimate of the average effect from 113 studies carried out from 1974 to June 2020, is small, but it turned out robust in both a frequentist and a Bayesian random-effect model.</p>
            <p>As shown by the cumulative analysis and the meta-regression with Year of publication as covariate meta-analyses, this effect does not show a negative trend from 1974 to 2020 and is quite stable since 1997 and after 70-80 experiments.</p>
            <p>Furthermore, the average effect, passes four different publication bias tests, reducing the probability that it could be due to the selective reporting of studies with statistically significant results. This interpretation is also supported by the low number of studies (18.5%) with statistically significant results. This outcome is partly consequent to the practice of publishing also statistically non-significant studies in the specialized journals and proceedings related to this field of investigation.</p>
            <p>Moreover, the similarity of effect size between the two levels of peer-review, add further support to the hypothesis that the &#x201c;file drawer&#x201d; is pretty empty, that is that this meta-analysis include all completed studies.</p>
            <p>If we consider the value of the average effect size, the lack of statistically significant results in many experiments are a consequence to their low statistical power as shown by the very low median statistical power of the meta-analysis.</p>
            <p>For those interested in this line of investigation the advice is clear. In order to achieve a statistical power of at least.80 with an alpha value of.05, each study must have at least 320 trials (estimated with G*Power, v.3.1.9.7, 
                <xref ref-type="bibr" rid="ref10">Faul, Erdfelder, Lang &amp; Buchner, 2007</xref>).</p>
            <p>However, this requirement can be reduced considerably if we consider the results of the moderators, in particular the selection of participants and the type of task. With selected participants carrying out a Type 3 task (i.e., with targets chosen before the ganzfeld phase and presented to a partner of the participant isolated in a separate and distant room simulating a sort of telepathic communication), the required trials can safely be reduced to 50.</p>
            <p>Could the average results be contaminated by the use of some questionable research practices (
                <xref ref-type="bibr" rid="ref19">John 
                    <italic toggle="yes">et al.</italic>, 2012</xref>), such as optional stopping, data exclusion, etc.? These practices are difficult to detect after the study publication, which is why it is recommended to preregister all methodological and statistical details before data collection. As far as it concerns this line of investigation, 
                <xref ref-type="bibr" rid="ref24">Wiseman, Watt and Kornbrot (2019)</xref>, documented that preregistration was recommended well before the so-called replication crisis faced by most scientific fields. Furthermore, a simulation of the use of some questionable research practices carried out by Bierman, Spottiswoode and Bijl (2016) on 78 studies related to anomalous perception in a ganzfeld environment, showed that even if the overall effect size could be inflated by the use of questionable research practices, it was not reduced to zero.</p>
            <p>Even if this paper is mainly devoted to the statistical analysis of the available evidence, it is important to consider possible theoretical frameworks that could account for such phenomena. Some of them are presented in the review by 
                <xref ref-type="bibr" rid="ref7">Carde&#x00f1;a (2018)</xref> and the book 
                <italic toggle="yes">Transcendent Mind</italic> by 
                <xref ref-type="bibr" rid="ref3">Baru&#x0161;s and Mossbridge (2017)</xref>. As a general theoretical framework, the main assumption is to consider mind not derived or constrained by their biological correlates but ontologically independent from them in agreement with some western and eastern philosophical interpretations such as idealism (
                <xref ref-type="bibr" rid="ref20">Kastrup, 2018</xref>), dual-aspect monism (
                <xref ref-type="bibr" rid="ref39">Walach, 2020</xref>), Advaita Vedanta (
                <xref ref-type="bibr" rid="ref30">Sedlmeier &amp; Srinivas, 2016</xref>), etc. If these interpretations of mind and consciousness are valid, what looks impossible or anomalous according to a physicalist or an eliminative reductionism interpretation, becomes perfectly normal.</p>
        </sec>
        <sec id="sec28">
            <title>Summary and recommendations</title>
            <p>The overall picture emerging from this meta-analysis is that there is sufficient evidence to claim that it is possible to observe a non-conventional (anomalous) perception in a ganzfeld environment. The available evidence seems not to be contaminated by publication bias and questionable research practices. However, in order to increase the probability of detecting such phenomena it is recommended to select participants and to use tasks which mimic a telepathic communication.</p>
            <p>As a methodological advice, it is recommended that researchers preregister the methodological and statistical details in open access registries as proposed by 
                <xref ref-type="bibr" rid="ref40">Watt and Kennedy (2016)</xref> and others, or even better to use a registered report format that makes all procedures more transparent before and during data collection and analysis. One of the best example, to be used as a model, is the Transparent Psi Project (
                <xref ref-type="bibr" rid="ref21">Kekecs 
                    <italic toggle="yes">et al.</italic>, 2019</xref>).</p>
            <p>Our hope is to update the evidence related to the anomalous perception in a ganzfeld environment with a meta-analysis of preregistered studies in the near future.</p>
        </sec>
        <sec id="sec29">
            <title>Data availability</title>
            <sec id="sec30">
                <title>Underlying data</title>
                <p>Figshare: Registered Report - Anomalous perception in a Ganzfeld condition: A meta-analysis of more than 40 years investigation, 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.6084/m9.figshare.12674618.v11">https://doi.org/10.6084/m9.figshare.12674618.v11</ext-link> (
                    <xref ref-type="bibr" rid="ref36">Tressoldi &amp; Storm, 2020</xref>).</p>
                <p>This project contains the following underlying data:
                    <list list-type="simple">
                        <list-item>
                            <label>-</label>
                            <p>GZMADatabase1974_2020 (.jasp and.xlsx)</p>
                        </list-item>
                        <list-item>
                            <label>-</label>
                            <p>GZMA Power (.xlsx)</p>
                        </list-item>
                        <list-item>
                            <label>-</label>
                            <p>GZMA Reference List (.doc)</p>
                        </list-item>
                    </list>
                </p>
            </sec>
            <sec id="sec31">
                <title>Extended data</title>
                <p>Figshare: Registered Report - Anomalous perception in a Ganzfeld condition: A meta-analysis of more than 40 years investigation, 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.6084/m9.figshare.12674618.v11">https://doi.org/10.6084/m9.figshare.12674618.v11</ext-link> (
                    <xref ref-type="bibr" rid="ref36">Tressoldi &amp; Storm, 2020</xref>).</p>
                <p>This project contains the following extended data:
                    <list list-type="simple">
                        <list-item>
                            <label>-</label>
                            <p>Syntax Details for Stage 1 and Stage 2 Registered Report</p>
                        </list-item>
                        <list-item>
                            <label>-</label>
                            <p>Figure S1</p>
                        </list-item>
                        <list-item>
                            <label>-</label>
                            <p>Figure S2</p>
                        </list-item>
                        <list-item>
                            <label>-</label>
                            <p>Figure S3</p>
                        </list-item>
                        <list-item>
                            <label>-</label>
                            <p>Figure S4</p>
                        </list-item>
                    </list>
                </p>
            </sec>
            <sec id="sec32">
                <title>Reporting guidelines</title>
                <p>Figshare: PRISMA checklist for &#x2018;Stage 2 Registered Report: Anomalous perception in a Ganzfeld condition - A meta-analysis of more than 40 years investigation&#x2019;, 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.6084/m9.figshare.12674618.v11">https://doi.org/10.6084/m9.figshare.12674618.v11</ext-link> (
                    <xref ref-type="bibr" rid="ref36">Tressoldi &amp; Storm, 2020</xref>).</p>
                <p>Data are available under the terms of the 
                    <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International license</ext-link> (CC-BY 4.0).</p>
            </sec>
        </sec>
    </body>
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    <sub-article article-type="reviewer-report" id="report224487">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.143962.r224487</article-id>
            <title-group>
                <article-title>Reviewer response for version 2</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Orepic</surname>
                        <given-names>Pavo</given-names>
                    </name>
                    <xref ref-type="aff" rid="r224487a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0001-6965-7578</uri>
                </contrib>
                <aff id="r224487a1">
                    <label>1</label>University of Geneva, Geneva, Switzerland</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>25</day>
                <month>1</month>
                <year>2024</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2024 Orepic P</copyright-statement>
                <copyright-year>2024</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport224487" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.51746.2"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>reject</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>This is a meta-analysis of the studies investigating the Ganzfeld effect. It builds up on the previous meta-analyses by including the most recent studies and applying different, more detailed statistical approaches. I have several major concerns related to this work.</p>
            <p> </p>
            <p> My biggest concern is that I found the title (as well as the story) misleading. The paper is actually about telepathic communication through the Ganzfeld effect, and not the Ganzfeld effect itself. This research question is not clearly stated. The ganzfeld effect is a much wider phenomenon that is based on Gestalt psychology, which was not even introduced. Moreover, other Ganzfeld effect studies that investigated the phenomenon itself and its neural correlates (e.g. works of Jiri Wackermann or Timo Schmidt) besides its alleged use for telepathic communication were not mentioned.&#x00a0; Generally, the manuscript is quite difficult to follow, needs more thorough proofreading (as detailed by the other reviewer), and important information about the reviewed studies (specified below) is missing. I would suggest rewriting the manuscript such that its real purpose becomes clearer.</p>
            <p> </p>
            <p> Another major issue that makes the results unconvincing is the inclusion of studies that are not properly peer-reviewed. Using &#x201c;peer review level&#x201d; as a correlate or a covariate in analyses and not observing a difference between &#x201c;proper&#x201d; and &#x201c;improper&#x201d; actually raises more doubts about the quality of the &#x201c;proper&#x201d; studies.</p>
            <p> </p>
            <p> The Ganzfeld procedure itself (especially limited to this context of communication) is not clearly introduced. What is the &#x201c;target&#x201d;, the &#x201c;decoys&#x201d;, the &#x201c;judging process&#x201d;, etc? What are the instructions for the participants? How is the hit rate estimated and computed? The difference between the three different conditions is also not clear. How can a target be chosen after the judgment phase? A schematic would be useful. Some of the covered studies should be introduced in detail to give the reader the impression of what is actually investigated here. I only understood what the paper was about after I read another paper on the topic.</p>
            <p> </p>
            <p> A table summarizing the reviewed studies and their main approaches and findings is missing. Since the goal of the article also seems to be to contrast this meta-analysis with the previous ones, this table should also indicate which studies were indicated in which other meta-analyses.</p>
            <p> </p>
            <p> I find it also strange to use bulletpoints in such a way throughout the manuscript, especially in the Introduction. It breaks the flow of the narrative, which is largely missing in the first place. The paragraphs are often not connected &#x2013; the manuscript reads more as a list than as a story.</p>
            <p> </p>
            <p> What is &#x201c;autoganzfeld&#x201d;? The difference between the introduced meta-analyses is not very clear. Did they cover different studies? What were their inclusion criteria and metrics? How is this meta-analysis advancing the previous ones &#x2013; is it simply margining the data?</p>
            <p> </p>
            <p> I am also not convinced that the problem of publication bias is solved. I would like to see the Test for Excess Success (TES) which examines whether the reported success rate of a set of experiments agrees with the estimated magnitude of the effect. For a relevant discussion, see Chapter 10 from the book of Herzog et al., Understanding Statistics and Experimental Design, Learning Materials in Biosciences, https://doi.org/10.1007/978-3-030-03499-3_10). They describe an interesting scenario in which out of 10 papers investigating precognition, 9 found a significant result (90%), whereas TES indicated that there is a 6% chance of having the same degree of success as the original report.</p>
            <p> </p>
            <p> Even if the evidence for the telepathic phenomena proves to be true &#x2013; there should be more discussion (as well as more introduction) on the supposed/proposed mechanisms behind it. What do different authors propose to explain the effect? How is this addressed in different studies? How in different meta-analyses? Are differences in supposed mechanisms taken into account? For a person completely outside of the field, such a &#x201c;gentle introduction&#x201d; is necessary to at least try to consider the possibility of such effects. I would suggest moving (and extending) the one paragraph talking about this from the Discussion to the Introduction, and in the Discussion focus on how the differences are reflected in different studies and meta-analyses.</p>
            <p> </p>
            <p> Generally, even though I find the topic very interesting, I do not find the work convincing. I am not familiar with the literature nor the methods in parapsychology, but for the field to advance and be more accepted by the scientific community, it would be useful if the research practices and writing style were done such that it is understandable to a person outside the field.</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>No</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Partly</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Partly</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>No</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>No</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Reviewer Expertise:</p>
            <p>neuroscience, hallucination engineering, speech, inner speech, self-consciousness, self-voice perception, EEG, intracranial EEG</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above.</p>
        </body>
        <back>
            <ref-list>
                <title>References</title>
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        <sub-article article-type="response" id="comment10988-224487">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Tressoldi</surname>
                            <given-names>Patrizio</given-names>
                        </name>
                        <aff>Studium Patavinum - Padova University, Italy</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>31</day>
                    <month>1</month>
                    <year>2024</year>
                </pub-date>
            </front-stub>
            <body>
                <p>My biggest concern is that I found the title (as well as the story) misleading. The paper is actually about telepathic communication through the Ganzfeld effect, and not the Ganzfeld effect itself. This research question is not clearly stated.</p>
                <p> Reply: The title indicates anomalous perception as tested using ganzfeld principles. In the revised introduction the reader wil see that &#x201c;telepathic communication&#x201d; is only one parapsychological modality tested (i.e., Type 3), as precognition (Type 1) and clairvoyance (Type 2) are not specifically identified and listed. These are nominal terms, so neutral terms (i.e, &#x2018;type&#x2019;) is preferred throughout the paper.</p>
                <p> The ganzfeld effect is a much wider phenomenon that is based on Gestalt psychology, which was not even introduced. Moreover, other Ganzfeld effect studies that investigated the phenomenon itself and its neural correlates (e.g. works of Jiri Wackermann or Timo Schmidt) besides its alleged use for telepathic communication were not mentioned.&#x00a0; Generally, the manuscript is quite difficult to follow, needs more thorough proofreading (as detailed by the other reviewer), and important information about the reviewed studies (specified below) is missing. I would suggest rewriting the manuscript such that its real purpose becomes clearer.</p>
                <p> </p>
                <p> 
                    <bold>Reply: acknowledged, but we believe we have been very clear about the specific use of ganzfeld in parapsychology. We feel the review, coupled with the information provided in the Introduction, makes it quite clear what the history of Ganzfeld psi testing was all about. Other than that, it is not clear to us what additional information Reviewer #3 would require.</bold>
                </p>
                <p> </p>
                <p> Another major issue that makes the results unconvincing is the inclusion of studies that are not properly peer-reviewed. Using &#x201c;peer review level&#x201d; as a correlate or a covariate in analyses and not observing a difference between &#x201c;proper&#x201d; and &#x201c;improper&#x201d; actually raises more doubts about the quality of the &#x201c;proper&#x201d; studies.</p>
                <p> </p>
                <p> 
                    <bold>Reply: It is not a case of &#x201c;Improper&#x201d; studies being assessed. Clearly, studies that might be regarded as having been reviewed to an &#x2018;adequate&#x2019; or &#x2018;sufficient&#x2019; standard (level 1) only, could easily have passed full review (level 2) since we showed that the level of peer-review &#x201c;did not yield differences in the effect sizes&#x201d;. That is, we should expect that a sharper peer-review would translate as significantly lower effect sizes under the assumption that psi effects are the result of design flaws.</bold>
                </p>
                <p> </p>
                <p> The Ganzfeld procedure itself (especially limited to this context of communication) is not clearly introduced. What is the &#x201c;target&#x201d;, the &#x201c;decoys&#x201d;, the &#x201c;judging process&#x201d;, etc? What are the instructions for the participants? How is the hit rate estimated and computed? The difference between the three different conditions is also not clear. How can a target be chosen after the judgment phase? A schematic would be useful. Some of the covered studies should be introduced in detail to give the reader the impression of what is actually investigated here. I only understood what the paper was about after I read another paper on the topic.</p>
                <p> </p>
                <p> A table summarizing the reviewed studies and their main approaches and findings is missing. Since the goal of the article also seems to be to contrast this meta-analysis with the previous ones, this table should also indicate which studies were indicated in which other meta-analyses.</p>
                <p> </p>
                <p> I find it also strange to use bulletpoints in such a way throughout the manuscript, especially in the Introduction. It breaks the flow of the narrative, which is largely missing in the first place. The paragraphs are often not connected &#x2013; the manuscript reads more as a list than as a story.</p>
                <p> </p>
                <p> 
                    <bold>Reply: Some of these problems are now fixed, and we find the use of bulletpoints is expedient and convenient for the readers (many meta-analyses employ this formatting).</bold>
                </p>
                <p> </p>
                <p> What is &#x201c;autoganzfeld&#x201d;? The difference between the introduced meta-analyses is not very clear. Did they cover different studies? What were their inclusion criteria and metrics? How is this meta-analysis advancing the previous ones &#x2013; is it simply margining the data?</p>
                <p> </p>
                <p> 
                    <bold>Reply: &#x201c;autoganzfeld&#x201d; was defined in the Introduction under the heading, Review of the Ganzfeld Meta-Analysis. In that review, the sequencing of the studies across the years indicates gradual improvements in study designs.</bold>
                </p>
                <p> </p>
                <p> I am also not convinced that the problem of publication bias is solved. I would like to see the Test for Excess Success (TES) which examines whether the reported success rate of a set of experiments agrees with the estimated magnitude of the effect. For a relevant discussion, see Chapter 10 from the book of Herzog et al., Understanding Statistics and Experimental Design, Learning Materials in Biosciences, https://doi.org/10.1007/978-3-030-03499-3_10). They describe an interesting scenario in which out of 10 papers investigating precognition, 9 found a significant result (90%), whereas TES indicated that there is a 6% chance of having the same degree of success as the original report.</p>
                <p> </p>
                <p> 
                    <bold>Reply: We could have conducted any number of tests on publication bias, and still not satisfied many readers/critics; we have conducted various such tests in our past meta-analytic papers and found similar results (e.g., see Storm, Tressoldi, &amp; Di Risio, 2010). Furthermore, if you check the z values of all experiments included in the database you will notice that only 30 (26.5%) are statistically significant, confirming that there is not an excess of sucess.</bold>
                </p>
                <p> </p>
                <p> Even if the evidence for the telepathic phenomena proves to be true &#x2013; there should be more discussion (as well as more introduction) on the supposed/proposed mechanisms behind it. What do different authors propose to explain the effect? How is this addressed in different studies? How in different meta-analyses? Are differences in supposed mechanisms taken into account? For a person completely outside of the field, such a &#x201c;gentle introduction&#x201d; is necessary to at least try to consider the possibility of such effects. I would suggest moving (and extending) the one paragraph talking about this from the Discussion to the Introduction, and in the Discussion focus on how the differences are reflected in different studies and meta-analyses.</p>
                <p> </p>
                <p> 
                    <bold>Reply: we agree possible mechanisms of the psi process could be discussed but it is likely there is more than one process besides telepathy to be discussed (i.e., precognition and clairvoyance as well), and to introduce various theories would go beyond the parameters of our paper which is largely statistical.</bold>
                </p>
                <p> </p>
                <p> Generally, even though I find the topic very interesting, I do not find the work convincing. I am not familiar with the literature nor the methods in parapsychology, but for the field to advance and be more accepted by the scientific community, it would be useful if the research practices and writing style were done such that it is understandable to a person outside the field.</p>
                <p> </p>
                <p> 
                    <bold>Reply: we are very sorry that this paper is not suitable for researchers not familiar with the literature, and the methods in parapsychology, and we add the characteristics of a Stage 2 meta-analysis Registered Report. Unfortunately, we cannot satisfy your request, unless we change completely the type of paper (see previous comment).</bold>
                </p>
            </body>
        </sub-article>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report177854">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.143962.r177854</article-id>
            <title-group>
                <article-title>Reviewer response for version 2</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Amorim</surname>
                        <given-names>Michel-Ange</given-names>
                    </name>
                    <xref ref-type="aff" rid="r177854a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-8455-1437</uri>
                </contrib>
                <aff id="r177854a1">
                    <label>1</label>Universite Paris-Saclay, Gif-sur-Yvette, &#x00ce;le-de-France, France</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>24</day>
                <month>1</month>
                <year>2024</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2024 Amorim MA</copyright-statement>
                <copyright-year>2024</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport177854" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.51746.2"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>My report is provided in a separate file available through this link:&#x00a0;
                <ext-link ext-link-type="uri" xlink:href="https://f1000research-files.f1000.com/linked/757620.Report_Tressoldi_Storm_2023_v2_.pdf">PDF file</ext-link>.</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Yes</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Partly</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Partly</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Partly</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Partly</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Reviewer Expertise:</p>
            <p>psychophysics, cognitive psychology,&#x00a0;cognitive and behavioral neuroscience, psi phenomena</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
        <sub-article article-type="response" id="comment10987-177854">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Tressoldi</surname>
                            <given-names>Patrizio</given-names>
                        </name>
                        <aff>Studium Patavinum - Padova University, Italy</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>31</day>
                    <month>1</month>
                    <year>2024</year>
                </pub-date>
            </front-stub>
            <body>
                <p>Thank you for your accurate review in particular the reproducibility of our results using our database and code syntax.</p>
                <p> Here follow our replies to all your comments.</p>
                <p> Main comments:</p>
                <p> 1-At the beginning of the &#x201c;Effect size measures&#x201d; section, the authors write &#x201c;As a standardized measure of effect size, we used [&#x2026;] Binomial Z score/&#x221a;number of trials using the number of trials, the hits score</p>
                <p> and the chance probability as raw scores.&#x201d;&#x00a0; However, in the xlsx data file provided by the authors, the</p>
                <p> values in the ES column correspond to Z/&#x221a;N, with N as the number of participants rather than the</p>
                <p> number of trials in the study.</p>
                <p> 
                    <bold>Reply: even if using trials or participants as a unit of analysis changes only some decimals of all results for this database, in this revision we used trials as this is the standard choice in all meta-analyses related to the topic investigated.</bold>
                </p>
                <p> </p>
                <p> 2-I also share the concerns expressed earlier by S Schmidt and J Utts about using webpages to compute exact binomial Z score values, either directly (with http://vassarstats.net/binomialX.html) or indirectly (with http://www.fourmilab.ch/rpkp/experiments/analysis/zCalc.html from the p value provided by binomialX.html).</p>
                <p> 
                    <bold>Reply: what is important is the correctness of the formulas and not where they are implemented. In our case, the choice of webpages could allow independent controls without using other software. In our case, the formulas are available on the websites. Thank you for pointing us the error related to the Z score of the third experiment.</bold>
                </p>
                <p> </p>
                <p> 3- Publication Bias tests</p>
                <p> &#x2026;.On the one hand, I find this statement incomplete and misleading because it ignores the confidence</p>
                <p> interval around the meta-analytic pooled point estimate.</p>
                <p> Reply: we added &#x201c;These results suggest that for publication bias to attenuate (to &#x201c;explain away&#x201d;) the observed point effect lower CI interval to the null, affirmative results would need to be at least 10 fold more likely to be published than nonaffirmative results&#x201d;, in the revised version as suggested.</p>
                <p> 4- Could the authors give a reference or spell out the practical (or theoretical) reasons for this</p>
                <p> statement: &#x201c;the .01 level, considered the smallest effect size of interest&#x201d;?</p>
                <p> 
                    <bold>Reply: This is an arbitrary cutoff close to the null (zero) level for this line of investigation. This level can change in other research fields.</bold>
                </p>
                <p> </p>
                <p> Further comments</p>
                <p> 1-Table 1 reports several descriptive values. The mean (SD) values in the Hit rate column are for 4 free-choice designs. However, the corresponding note at the bottom of Table &#x201c;this value is purely</p>
                <p> descriptive because not all studies are 4 free-choice designs&#x201d; is ambiguous;</p>
                <p> 
                    <bold>Reply: we changed the proportion of hits with the proportion of hits above the chance level a measure that takes into account the differences in the chance level in the different experiments.</bold>
                </p>
                <p> </p>
                <p> 2-The manuscript mentions several supplementary figures that are not currently available at the Figshare link the authors provided</p>
                <p> 
                    <bold>Reply: Sorry for that. Now we have uploaded the Forest, the cumulative and the&#x00a0; Sequential Bayes Factor in the Stage 2 Supplementary Figures.doc file in the figshare repository.</bold>
                </p>
                <p> </p>
                <p> 3- Unforfunately, the authors do not provide any funnel plot figure. I recommend the authors to use the</p>
                <p> metaviz R library to generate a funnel plot with power regions</p>
                <p> 
                    <bold>Reply: in the text of the revised version we invited the readers to read your review and in particular your power funnel plot.</bold>
                </p>
                <p> </p>
                <p> 4- Rationale of the statistical analysis and Discussion of the results</p>
                <p> Surprisingly, they never clearly wrote down (or maybe I missed something?) that the theoretical GZ effect size would be &#x201c;Z /&#x221a;N = 0.1&#x201d;.</p>
                <p> 
                    <bold>Reply: the use of this prior in the Bayesian meta-analysis is an arbitrary choice based on the overall frequentist meta-analysis, and the previous meta-analyses e.g. Storm &amp; Tressoldi, 2010.</bold>
                </p>
            </body>
        </sub-article>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report205990">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.143962.r205990</article-id>
            <title-group>
                <article-title>Reviewer response for version 2</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Radin</surname>
                        <given-names>Dean</given-names>
                    </name>
                    <xref ref-type="aff" rid="r205990a1">1</xref>
                    <xref ref-type="aff" rid="r205990a2">2</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0003-0041-322X</uri>
                </contrib>
                <aff id="r205990a1">
                    <label>1</label>Integral and Transpersonal Psychology, California Institute of Integral Studies, San Francisco, California, USA</aff>
                <aff id="r205990a2">
                    <label>2</label>Research, Institute of Noetic Sciences, Petaluma, California, USA</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>2</day>
                <month>11</month>
                <year>2023</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2023 Radin D</copyright-statement>
                <copyright-year>2023</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport205990" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.51746.2"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>This is a follow-up to a previous meta-analysis of the ganzfeld condition experimental database. It uses the latest meta-analytic techniques and adds further evidence to the original conclusion.</p>
            <p> </p>
            <p> My primary comment about this document is that it would be difficult for those who are not already familiar with the relevant literature to fully understand what this experiment is about.&#x00a0;For example, in the Introduction, participants are referred to as "they," but given that "they" is sometimes used a neutral gender term, we cannot tell if this entails one person or two, who is describing their impressions aloud, how that information is recorded, who judges that information against the target, how many targets and decoys are involved (we read four at one point, and binary at another), and so on.</p>
            <p> </p>
            <p> Because of such confusions, I think it would be much clearer if the various types of ganzfeld condition experiments that are being considered were defined upfront, and then state how many participants are involved in each kind of study, and exactly what each of their roles are. As currently written, some of this information is provided later in the Introduction, but by the time the reader gets to that description they will already be confused.</p>
            <p> </p>
            <p> Other phases that might be clarified:</p>
            <p> </p>
            <p> &gt;&#x00a0;Once participants are sensorially isolated from external visual and auditory stimulation, they are in a favorable condition</p>
            <p> </p>
            <p> I'd prefer a more cautious "
                <italic>thought to be</italic> a favorable condition"</p>
            <p> </p>
            <p> &gt;&#x00a0;in the mainstream journal&#x00a0;
                <italic>Psychological Bulletin.</italic>
            </p>
            <p> </p>
            <p> The word 
                <italic>mainstream </italic>is unnecessary.</p>
            <p> </p>
            <p> &gt;&#x00a0;Moreover the autoganzfeld procedure avoids</p>
            <p> </p>
            <p> Maintain consistency in tenses. Thus, "avoided" and not avoids.</p>
            <p> </p>
            <p> &gt;&#x00a0;They overall reported hit rate&#x00a0;</p>
            <p> </p>
            <p> You mean "
                <italic>The </italic>overall reported hit rate"</p>
            <p> </p>
            <p> &gt;&#x00a0;average standardized effect size</p>
            <p> </p>
            <p> Meaning? There are many definitions for effect size.</p>
            <p> </p>
            <p> &gt;&#x00a0;with the more advanced statistical procedures that should overcome the limitations of the previous meta-analyses</p>
            <p> </p>
            <p> Such as?&#x00a0; List these limitations.</p>
            <p> </p>
            <p> &gt;&#x00a0;have been approved in the Stage 1</p>
            <p> </p>
            <p> The Stage 1 what? That term only makes sense if one is already familiar with how this journal works.&#x00a0;</p>
            <p> </p>
            <p> &gt;&#x00a0;the editorial policy of accepting paper&#x00a0;</p>
            <p> </p>
            <p> You mean "papers".&#x00a0; Note: There are many other examples like this that a proofreader would catch. I suggest that the authors do a very careful review&#x00a0; of the text for these kinds of grammatical mistakes. I will mention some (not all) of them below.</p>
            <p> </p>
            <p> &gt;&#x00a0;Studies must use human participants only (not animals);</p>
            <p> </p>
            <p> Are there ganzfeld studies with animals?</p>
            <p> </p>
            <p> &gt;&#x00a0;Number of participants must be in excess of two to avoid the inherent problems that are typical in case studies;</p>
            <p> </p>
            <p> This is confusing because we don't know if you mean the number of participants per session, or the number of sessions.</p>
            <p> </p>
            <p> &gt;&#x00a0;Target selection must be randomized by using a Random Number Generator (RNG) in a computer or similar electronic device</p>
            <p> </p>
            <p> An RNG "in" a computer can mean a pseudorandom algorithm or a true hardware-based RNG. Clarify.</p>
            <p> </p>
            <p> &gt;&#x00a0;Randomization procedures must not be manipulated by the experimenter or participant;</p>
            <p> </p>
            <p> What does "manipulated" mean in this context? If I select from a table of random numbers, that is a manual process, and thus could be interpreted as manipulated.</p>
            <p> </p>
            <p> &gt;&#x00a0;
                <italic>Researches In Parapsychology</italic>
            </p>
            <p> </p>
            <p> You mean "conference proceedings such as those published in a book series called&#x00a0;
                <italic>
                    <bold>Research </bold>In Parapsychology"</italic>
            </p>
            <p>
                <italic> </italic>
            </p>
            <p>
                <italic> &gt;&#x00a0;</italic>As standardized measure of effect size, we used that one&#x00a0;</p>
            <p> </p>
            <p> we used 
                <bold>the </bold>one</p>
            <p> </p>
            <p> &gt;&#x00a0;Binomial Z score/&#x221a;number of trials using the number of trials, the hits score and the chance probability as raw scores</p>
            <p> </p>
            <p> A comma is necessary to clarify this sentence: Binomial Z score/&#x221a;number of trials
                <bold>,</bold> using the number of trials, the hits score and the chance probability as raw scores</p>
            <p> </p>
            <p> 
                <italic>&gt;&#x00a0;</italic>were transformed in the Hedge&#x2019;s&#x00a0;
                <italic>g</italic>&#x00a0;effect sizes,</p>
            <p> </p>
            <p> were transformed into 
                <bold>the </bold>Hedge&#x2019;s&#x00a0;
                <italic>g</italic>&#x00a0;effect sizes,</p>
            <p> </p>
            <p> &gt;&#x00a0;a Bayesian random-effect model for testing its robustness</p>
            <p> </p>
            <p> What does "it" refer to?</p>
            <p> </p>
            <p> &gt;&#x00a0;See syntax details provided as extended data</p>
            <p> </p>
            <p> What does 
                <bold>extended data </bold>mean?&#x00a0;</p>
            <p> </p>
            <p> In Table 2 we find a cell with the number 1909. It isn't clear what that refers to. Is that a Bayes Factor?</p>
            <p> </p>
            <p> &gt;&#x00a0;We compared the influence of the following tree moderators:</p>
            <p> </p>
            <p> What is a tree moderator? Do you mean 
                <bold>three </bold>moderators?</p>
            <p> </p>
            <p> &gt; the &#x201c;file drawer&#x201d; is pretty empty,</p>
            <p> </p>
            <p> Can you be more objective? Pretty can mean all sorts of things.</p>
            <p> </p>
            <p> &gt;The results of the cumulative meta-analysis is represented&#x00a0;</p>
            <p> </p>
            <p> Results 
                <bold>are</bold>, not is.</p>
            <p> </p>
            <p> &gt;&#x00a0;&#x00a0;Thus, it appears to be stable</p>
            <p> </p>
            <p> Should probably emphasize 
                <italic>cumulatively </italic>stable, or stable on average.</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Partly</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Yes</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Yes</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Reviewer Expertise:</p>
            <p>Experimental psychology, parapsychology, psychophysiology, physics, and statistics.</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
        <sub-article article-type="response" id="comment10986-205990">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Tressoldi</surname>
                            <given-names>Patrizio</given-names>
                        </name>
                        <aff>Studium Patavinum - Padova University, Italy</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>31</day>
                    <month>1</month>
                    <year>2024</year>
                </pub-date>
            </front-stub>
            <body>
                <p>Sorry for the late response to your review, but we preferred to wait for further reviews' before revising the paper.</p>
                <p> Here are the replies to your comments.</p>
                <p> </p>
                <p> &gt;My primary comment about this document is that it would be difficult for those who are not already familiar with the relevant literature to fully understand what this experiment is about.&#x00a0;For example, in the Introduction, participants are referred to as "they," but given that "they" is sometimes used a neutral gender term, we cannot tell if this entails one person or two, who is describing their impressions aloud, how that information is recorded, who judges that information against the target, how many targets and decoys are involved (we read four at one point, and binary at another), and so on.</p>
                <p> </p>
                <p> Because of such confusion, I think it would be much clearer if the various types of ganzfeld condition experiments that are being considered were defined upfront, and then state how many participants are involved in each kind of study, and exactly what each of their roles are. As currently written, some of this information is provided later in the Introduction, but by the time the reader gets to that description they will already be confused.</p>
                <p> Reply: See restructured and corrected text in the Introduction, margin comments, and additional text.</p>
                <p> </p>
                <p> Other phases that might be clarified:</p>
                <p> 
                    <bold>Reply: We revised the introduction following these suggestions</bold>
                </p>
                <p> </p>
                <p> What does extended data mean?</p>
                <p> 
                    <bold>Reply: This is an editorial requirement replacing the Supplementary Material.</bold>
                </p>
                <p> </p>
                <p> In Table 2 we find a cell with the number 1909. It isn't clear what that refers to. Is that a Bayes Factor?</p>
                <p> 
                    <bold>Reply: Correct, even If after a re-analysis this value is now 85 in the range of "very strong evidence" .</bold>
                </p>
                <p> </p>
                <p> &gt; the &#x201c;file drawer&#x201d; is pretty empty,</p>
                <p> </p>
                <p> Can you be more objective? Pretty can mean all sorts of things.</p>
                <p> 
                    <bold>Reply: we deleted the term &#x201c;pretty&#x201d;.</bold>
                </p>
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        </sub-article>
    </sub-article>
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