<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN" "http://jats.nlm.nih.gov/publishing/1.2/JATS-journalpublishing1.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="research-article" dtd-version="1.2" xml:lang="en">
    <front>
        <journal-meta>
            <journal-id journal-id-type="pmc">F1000Research</journal-id>
            <journal-title-group>
                <journal-title>F1000Research</journal-title>
            </journal-title-group>
            <issn pub-type="epub">2046-1402</issn>
            <publisher>
                <publisher-name>F1000 Research Limited</publisher-name>
                <publisher-loc>London, UK</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="doi">10.12688/f1000research.125184.2</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Research Article</subject>
                </subj-group>
                <subj-group>
                    <subject>Articles</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Stress-Based Lattice Structure Design for a Motorbike Application</article-title>
                <fn-group content-type="pub-status">
                    <fn>
                        <p>[version 2; peer review: 2 approved]</p>
                    </fn>
                </fn-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Ferretti</surname>
                        <given-names>Patrich</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Project Administration</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Fusari</surname>
                        <given-names>Elena</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Alessandri</surname>
                        <given-names>Giulia</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0003-1586-4090</uri>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="yes">
                    <name>
                        <surname>Freddi</surname>
                        <given-names>Marco</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Software</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0003-3745-7496</uri>
                    <xref ref-type="corresp" rid="c1">a</xref>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Francia</surname>
                        <given-names>Daniela</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Resources</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <aff id="a1">
                    <label>1</label>Department of Industrial Engineering, University of Bologna, Bologna, Italy, 40136, Italy</aff>
            </contrib-group>
            <author-notes>
                <corresp id="c1">
                    <label>a</label>
                    <email xlink:href="mailto:marco.freddi2@unibo.it">marco.freddi2@unibo.it</email>
                </corresp>
                <fn fn-type="conflict">
                    <p>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>29</day>
                <month>11</month>
                <year>2023</year>
            </pub-date>
            <pub-date pub-type="collection">
                <year>2022</year>
            </pub-date>
            <volume>11</volume>
            <elocation-id>1162</elocation-id>
            <history>
                <date date-type="accepted">
                    <day>16</day>
                    <month>11</month>
                    <year>2023</year>
                </date>
            </history>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2023 Ferretti P et al.</copyright-statement>
                <copyright-year>2023</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <self-uri content-type="pdf" xlink:href="https://f1000research.com/articles/11-1162/pdf"/>
            <abstract>
                <sec>
                    <title>Background</title>
                    <p>The &#x201c;drive by wire&#x201d; mechanism for managing the throttle is not applied to every modern motorcycle, but it is often managed through a steel wire. Here, there is a cam on the throttle control. Its shape allows the throttle opening to be faster or slower and its angle of rotation, required for full opening, to be greater or less. The maximum angle a rider&#x2019;s wrist can withstand depends on numerous musculoskeletal mobility factors, often limited by falls or surgery.</p>
                </sec>
                <sec>
                    <title>Methods</title>
                    <p>Using a Progrip knob with interchangeable cams allows the customization of a special cam profile, to ensure the best engine response to throttle rotation and ergonomics for the rider. The use of FEA software and lattice structures, allows to realize a lightweight and efficient design, targeted for fabrication with additive manufacturing technologies.</p>
                </sec>
                <sec>
                    <title>Results</title>
                    <p>The cam was manufactured by exploiting MSLA technology. Finally, a dimensional inspection procedure was performed before assembly. The main result is to have obtained a lighter and cheaper component than the original.</p>
                </sec>
                <sec>
                    <title>Conclusions</title>
                    <p>This study has allowed the design of a mechanical component consisting of innovative shape, light weight, and ergonomics. Furthermore, it demonstrates the effectiveness in the use of lattice structures to enable weight optimization of a component while minimizing the increase in its compliance.</p>
                </sec>
            </abstract>
            <kwd-group kwd-group-type="author">
                <kwd>MSLA</kwd>
                <kwd>water washable resin</kwd>
                <kwd>lattice structure</kwd>
                <kwd>nTopology</kwd>
                <kwd>Design for additive manufacturing</kwd>
                <kwd>Stereolithography tooling</kwd>
                <kwd>Shape optimization</kwd>
                <kwd>CAD/CAM</kwd>
            </kwd-group>
            <funding-group>
                <funding-statement>The author(s) declared that no grants were involved in supporting this work.</funding-statement>
            </funding-group>
        </article-meta>
        <notes>
            <sec sec-type="version-changes">
                <label>Revised</label>
                <title>Amendments from Version 1</title>
                <p>In this version of the work, more details have been added regarding the explanation of the component's functioning, its lightweighting phases in the central part, and the verification through FEM simulations considering the two main stress cases. A comprehensive revision of the presentation of concepts and the selection of appropriate terminologies has been conducted to enhance the quality of the work. The title has also been amended, as have some of the figures.</p>
            </sec>
        </notes>
    </front>
    <body>
        <sec id="sec1" sec-type="intro">
            <title>Introduction</title>
            <p>Presently, Additive Manufacturing (AM) stands as the sole technology capable of ensuring the cost-effective production of customized components. Leveraging the latest structural optimization software and lightweighting capabilities enables the design of these components. 3D printing presents a versatile opportunity to manufacture components using diverse materials, ranging from polymeric substances to metals. When discussing the design of components featuring &#x201c;lattice&#x201d; structures, additive manufacturing invariably emerges as the sole viable choice (
                <xref ref-type="bibr" rid="ref19">Pan 
                    <italic toggle="yes">et al.</italic>, 2020</xref>). Many recently developed geometries have the distinction of being weight-optimized through the use of special internal &#x201c;lattice&#x201d; structures (
                <xref ref-type="bibr" rid="ref12">Gibson, 1989</xref>; 
                <xref ref-type="bibr" rid="ref22">Tamburrino 
                    <italic toggle="yes">et al.</italic>, 2018</xref>; 
                <xref ref-type="bibr" rid="ref23">Tao &amp; Leu, 2016</xref>). These are merely internal ramifications of the geometry that can provide good stiffness while leaving numerous gaps to minimize the weight of the final structure (
                <xref ref-type="bibr" rid="ref17">Messner, 2016</xref>). The primary advantage lies in maintaining an unchanged external geometry of the component. This factor holds significant importance, given that the component&#x2019;s shape frequently serves as the principal design constraint. The internal patterns of these geometries can be composed of straightforward shapes, including hexahedra or tetrahedra cells, octets (
                <xref ref-type="bibr" rid="ref6">Deshpande 
                    <italic toggle="yes">et al.</italic>, 2001</xref>) or classical hexagonal honeycombs, or more complex surfaces governed by mathematical equations in 3D space (
                <xref ref-type="bibr" rid="ref7">du Plessis 
                    <italic toggle="yes">et al.</italic>, 2018</xref>). A classic example is the Gyroid structure (
                <xref ref-type="bibr" rid="ref15">Khaderi 
                    <italic toggle="yes">et al.</italic>, 2014</xref>), but many others exist, such as Neovius cells (
                <xref ref-type="bibr" rid="ref16">Khan &amp; Abu Al-Rub, 2017</xref>), Lidinoid and Schwarz (
                <xref ref-type="bibr" rid="ref21">Shin 
                    <italic toggle="yes">et al.</italic>, 2012</xref>). These belong to &#x201c;TPMS&#x201d; (Triply Periodic Minimal Surface) cells category, much deployed in this design context (
                <xref ref-type="bibr" rid="ref1">Al-Ketan &amp; Abu Al-Rub, 2019</xref>; 
                <xref ref-type="bibr" rid="ref11">Gandy 
                    <italic toggle="yes">et al.</italic>, 2001</xref>; 
                <xref ref-type="bibr" rid="ref14">Jung 
                    <italic toggle="yes">et al.</italic>, 2006</xref>; 
                <xref ref-type="bibr" rid="ref20">Savio 
                    <italic toggle="yes">et al.</italic>, 2019</xref>).</p>
            <sec id="sec1.1">
                <title>MSLA (Mashed Stereolithography) Resin Printing</title>
                <p>Stereolithography (SLA), a patented printing technology from the 1980s, employs a laser to fabricate components. The laser precisely targets the transparent bottom of a photosensitive surface within a reservoir filled with resin. This resin, responsive to ultraviolet light, undergoes curing and solidification solely in the specific regions irradiated by the laser, resulting in the formation of a material layer. Typically, the resins utilized in MSLA technology consist of thermoset polymers, renowned for their favorable mechanical properties and widespread industrial applicability (
                    <xref ref-type="bibr" rid="ref5">Croccolo 
                        <italic toggle="yes">et al.</italic>, 2019</xref>). The process is repeated until the component is created. This process offers numerous advantages stemming from the superior isotropy of the printed component, coupled with exceptional surface finish and intricate detailing. Currently, SLA technology is undergoing various advancements geared toward significantly reducing costs and enhancing accessibility to the public, all while retaining its inherent benefits. One such advancement is &#x2018;MSLA&#x2019; (Masked Stereolithography), which notably improves upon traditional &#x2018;SLA&#x2019; technology in terms of part production speed. MSLA utilizes an LCD screen within the printer, featuring pixels whose quantity directly influences the resolution of the manufactured part. The screen functions as a mask for ultraviolet light, creating the 2D layer drawing to be printed by selectively activating or deactivating pixels. This simultaneous photo-polymerization of each point within a layer eliminates the necessity for multiple laser paths, as seen in SLA. Resin-based printing technologies excel in realizing lattice structures, effectively constructing the beams composing the lattice and capturing intricate details, even at a microscale.</p>
            </sec>
            <sec id="sec1.2">
                <title>Customization and 3D printed parts</title>
                <p>The need of customised components is of great interest in numerous fields, ranging from biomedical (
                    <xref ref-type="bibr" rid="ref9">Frizziero, Santi, Leon-Cardenas, Donnici, Liverani, Papaleo, 
                        <italic toggle="yes">et al.</italic>, 2021a</xref>, 
                    <xref ref-type="bibr" rid="ref10">2021b</xref>) to mechanical engineering especially the automotive field. For several years now there have been dedicated departments within the companies themselves to meet specific customer requirements (
                    <xref ref-type="bibr" rid="ref8">Fantini 
                        <italic toggle="yes">et al.</italic>, 2016</xref>; 
                    <xref ref-type="bibr" rid="ref27">Zhang 
                        <italic toggle="yes">et al.</italic>, 2021</xref>). Prior to the rise of Additive Manufacturing, the production of a singular mechanical component relied on one or multiple &#x201c;traditional&#x201d; technologies, which remain prevalent in today&#x2019;s industry. This process often incurred exceedingly high and, at times, unmanageable costs, as these expenses were not rationalized by the production of a solitary component. In particular, the level of customisation that can be achieved through the use of 3D printing is unattainable by any other technologies, as well demonstrated in literature (
                    <xref ref-type="bibr" rid="ref13">Ibhadode, 2023</xref>). This makes the additive manufacturing extremely competitive, both in terms of cost and of the complexity of the geometries that can be produced. Many examples in the literature demonstrate how additive manufacturing is the winning choice. The applications go from the aerospace sector (
                    <xref ref-type="bibr" rid="ref18">Moon 
                        <italic toggle="yes">et al.</italic>, 2015</xref>; 
                    <xref ref-type="bibr" rid="ref24">Totaro &amp; G&#x00fc;rdal, 2009</xref>; 
                    <xref ref-type="bibr" rid="ref25">Vasiliev &amp; Razin, 2006</xref>; 
                    <xref ref-type="bibr" rid="ref28">Zhu 
                        <italic toggle="yes">et al.</italic>, 2015</xref>) to the medical-health sector cited, from the automotive sector ( 
                    <xref ref-type="bibr" rid="ref2">Bacciaglia 
                        <italic toggle="yes">et al.</italic>, 2020a</xref>; 
                    <xref ref-type="bibr" rid="ref26">Yin 
                        <italic toggle="yes">et al.</italic>, 2018</xref>) to the entertainment sector (
                    <xref ref-type="bibr" rid="ref3">Bacciaglia 
                        <italic toggle="yes">et al.</italic>, 2020b</xref>).</p>
            </sec>
        </sec>
        <sec id="sec2">
            <title>Part modelling process and lattice creation</title>
            <p>The design of the components is conditioned by various factors: the production process adopted (resin printing); the perfect intercompatibility with respect to the Progrip mod.708 grip; the standard gas control scroll and finally the geometry required by the rider. The workflow followed is shown in 
                <xref ref-type="fig" rid="f1">Figure 1</xref>.</p>
            <fig fig-type="figure" id="f1" orientation="portrait" position="float">
                <label>Figure 1. </label>
                <caption>
                    <title>Project&#x2019;s workflow.</title>
                </caption>
                <graphic id="gr1" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/158715/1baa990d-2f76-4458-8d75-6123bed780d8_figure1.gif"/>
            </fig>
            <p>The starting point is the CAD creation of an initial cam model that had similar overall dimensions to those provided in the Progrip kit, but with a custom profile. A quick action throttle cable, commonly referred to as &#x201c;quick action cam,&#x201d; is an accessory used in motorcycling to enhance the responsiveness of the throttle control, typically for performance improvements. The quick action throttle is primarily composed of a specialized throttle cable that is shorter in length compared to the stock throttle cable. This cable connects the throttle grip on the handlebar to the carburetor or fuel injection system. The shortened cable means that even a slight twist of the throttle grip results in a wider opening of the throttle body or fuel injector. This immediate response of the throttle provides a quick power increase when the rider twists the grip. The external profile of the cam possesses a slightly larger diameter compared to the cam provided by Progrip, enabling a full opening of the throttle valve within less than a 90&#x00b0; rotation of the grip lever. The default cam accompanying the Progrip knob demands an angle exceeding 90&#x00b0;. In our particular scenario, constrained by limited wrist mobility, this standard cam impedes the rider from fully extending the throttle. The original cam design is presented in 
                <xref ref-type="fig" rid="f2">Figure 2</xref>. This component is manufactured using Polyamide/Nylon PA6 and PA66.</p>
            <fig fig-type="figure" id="f2" orientation="portrait" position="float">
                <label>Figure 2. </label>
                <caption>
                    <title>Mechanical drawing of the original cam.</title>
                </caption>
                <graphic id="gr2" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/158715/1baa990d-2f76-4458-8d75-6123bed780d8_figure2.gif"/>
            </fig>
            <p>The cam was then later divided into two separate bodies as can be seen from 
                <xref ref-type="fig" rid="f3">Figure 3</xref>. A body that is the unmodifiable geometry and the other one (central part) in which apply lattice optimization to minimize the material used during printing and, at the same time, ensure the maximum stiffness values and required performance. The two bodies were exported as an assembly file in STEP format. A clarifying assembly/usage diagram on the motorcycle handlebar is also presented in 
                <xref ref-type="fig" rid="f3">Figure 3</xref>.</p>
            <fig fig-type="figure" id="f3" orientation="portrait" position="float">
                <label>Figure 3. </label>
                <caption>
                    <title>(a) Separation of the volume to be preserved from that for optimization; (b) Diagram of mounting/using the cam on a motorcycle handlebar.</title>
                </caption>
                <graphic id="gr3" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/158715/1baa990d-2f76-4458-8d75-6123bed780d8_figure3.gif"/>
            </fig>
            <p>The geometry is then imported into nTop, which is a software dedicated to the design of lattice or topology-optimized components and subsequent structural verification. The component model is imported as an assembly, divided into two separate volumes. One is intended to remain unchanged at the end of the design process; the other is to be lightweighted with a lattice structure. The outer part of the throttle cam features a shape that was deemed non-optimizable. The edge of the cam around the central crown, utilized for mounting on the handlebar and suitable for transmitting the torque generated by the rider&#x2019;s hand during acceleration, already possesses an optimized shape and thickness. The upper section of the cam is designed with a profile to achieve the necessary length when coupled with the constrained steel wire within the orifice, essential for adjustment purposes. The sole modifiable and reducible volume is highlighted in pink. The process leading to the final generation and export of a differentiated density lattice structure is characterized by five distinct steps as shown in 
                <xref ref-type="fig" rid="f1">Figure 1</xref>. Within the nTop software, two simulations were configured, sharing a fixed constraint inside the cam while varying in applied loads. The initial simulation depicts the maximum throttle opening, where the throttle control is fully rotated, generating force through the return spring onto the cam via a steel wire. A force of 30 N was applied in the first case within the eyelet, acting tangentially to the termination of the fixed steel wire on the cam. To replicate the contact pressure between the cam and the steel wire, 2 MPa of pressure was evenly distributed across an area resembling the wire&#x2019;s dimensions. In the second load case, 30 N of force normal to the contact surface of the accelerator nut was applied to simulate the uncontrolled release of the gas grip, resulting in the impact of a specific part of the cam as an endstop against the throttle scroll. The two load cases can be seen in 
                <xref ref-type="fig" rid="f4">Figure 4</xref>. For the mesh, 0.5 mm maximum allowable length per tetrahedral element was imposed, and 0.01 mm maximum allowable gap between the actual shape of the component and the mesh. A growth rate of 2 was also imposed. The choice of second-order finite elements was made to ensure better accuracy in results at the expense of longer simulation times. In this case, the choice is most suitable when dealing with printed materials (resin) and particularly thin internal structures. These conditions result in the generation of 973431 elements and 200049 nodes. The contact between the two volumes was defined and set as a perfect bonding (Structural Bonded Contact in nTop). Isotropic properties were assigned for the material as given below: Young&#x2019;s modulus of 1930 MPa (average value compared with the properties stated in 
                <xref ref-type="table" rid="T1">Table 1</xref>) and Poisson&#x2019;s coefficient of 0.38. A material exhibiting linear-elastic behavior was initially assumed, a presumption that was subsequently validated by the minimal deformations observed in the component due to the applied loads and operational conditions. Both structural simulations, utilizing identical meshes, were executed, and the resultant displacement and stress scalar fields were stored for future analysis.</p>
            <fig fig-type="figure" id="f4" orientation="portrait" position="float">
                <label>Figure 4. </label>
                <caption>
                    <title>Load cases.</title>
                </caption>
                <graphic id="gr4" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/158715/1baa990d-2f76-4458-8d75-6123bed780d8_figure4.gif"/>
            </fig>
            <table-wrap id="T1" orientation="portrait" position="float">
                <label>Table 1. </label>
                <caption>
                    <title>Mechanical properties of the resin used for printing the prototype.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1" valign="top">Parameters</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Value</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Unit</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Viscosity</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">150-300</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">MPa*s</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Density</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">1.05-1.25</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">g/cm
                                <sup>3</sup>
                            </td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Flexural Modulus</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">1682-2175</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">MPa</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Flexural Strength</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">40-70</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">MPa</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Heat Distortion Temperature</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">80</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">C&#x00b0;</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Linear Shrinkage Rate %</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">1.05-1.35</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">/</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Tensile Strength</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">30-48</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">MPa</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Tensile Modulus</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">1779-2385</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">MPa</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Elongation at Break</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">11-20</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">%</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Poisson Ratio</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.38</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">/</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Harness (Shore D)</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">70-80</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">/</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Density after cured</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">1.09-1.18</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">g/cm
                                <sup>3</sup>
                            </td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Notched impact Strength</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">41-48</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">J/m</td>
                        </tr>
                    </tbody>
                </table>
            </table-wrap>
            <p>The results in terms of stress and displacements are shown in 
                <xref ref-type="fig" rid="f5">Figure 5</xref> and 
                <xref ref-type="fig" rid="f6">Figure 6</xref>. Then, a scalar field (Field from Point Map) has been defined as a function from R3 to R1, taking as input the spatial position (x, y, z) of a node in the component mesh and returns as output the von Mises stress value evaluated at that node.</p>
            <fig fig-type="figure" id="f5" orientation="portrait" position="float">
                <label>Figure 5. </label>
                <caption>
                    <title>Von Mises stress evaluated for the two analyses.</title>
                </caption>
                <graphic id="gr5" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/158715/1baa990d-2f76-4458-8d75-6123bed780d8_figure5.gif"/>
            </fig>
            <fig fig-type="figure" id="f6" orientation="portrait" position="float">
                <label>Figure 6. </label>
                <caption>
                    <title>Map of local material displacements (in mm) analyzed in the first loading case and in the second both on the original cam.</title>
                </caption>
                <graphic id="gr6" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/158715/1baa990d-2f76-4458-8d75-6123bed780d8_figure6.gif"/>
            </fig>
            <p>In handling two distinct load cases and their respective stress fields, our approach involved defining an overall stress field. This aggregate field assigns each node within the domain the highest stress value obtained from a comparison of the values at that specific node in the two fields. This method ensures the consideration of any stress peaks present in either load case. Utilizing an average of the values from the two fields would have precluded this outcome.</p>
            <p>To develop a final design capable of accommodating the density variation directly linked to stress variation within the component, determining the cell type and truss dimensions becomes imperative. The choice was to use the Tet-oct vertex centroid type, with a cell size equal to 7 mm. The selection of this cell type primarily stems from its capability to provide medium to high material density, ensuring minimized regions devoid of material within the volume undergoing shape modifications in the component. Additionally, its compatibility with resin material for printing contributes to its ease of manufacturability. The lattice thus defined is trimmed so that it remains included in the volume intended for lattice optimization (1); then, we proceed by removing the &#x201c;floating beams,&#x201d; elements disconnected from the remaining lattice defined in that volume. At that point, we proceed by defining the thickness variability (Thicken Lattice) according to the stress field. In the case under consideration, the minimum stress value was assigned a thickness of 0.8 mm, and the maximum value of 2.5 mm. These values were defined following an optimization loop as can be seen by the blue arrow in 
                <xref ref-type="fig" rid="f1">Figure 1</xref>. The goal was to minimize the volume of material use, trying to contain stress and deformations at the same time. The value of 0.8 mm represents the minimum beam thickness achievable with this resin. This means that going below this thickness does not allow the realization of the truss beams. A useful representation for understanding these last design steps is offered in 
                <xref ref-type="fig" rid="f7">Figure 7</xref>.</p>
            <fig fig-type="figure" id="f7" orientation="portrait" position="float">
                <label>Figure 7. </label>
                <caption>
                    <title>Sequence of steps constructed from the definition of the lattice grid (1) to its thickening based on the stress field (2), to the creation of the final part ready to be validated (3).</title>
                </caption>
                <graphic id="gr7" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/158715/1baa990d-2f76-4458-8d75-6123bed780d8_figure7.gif"/>
            </fig>
            <p>Re-simulating the component&#x2019;s behavior is crucial as material removal diminishes its overall stiffness. Additionally, the interconnections between trusses within the lattice zone may induce localized stress peaks. To validate the resulting structure, a new mesh configuration needs defining, with two possible approaches available. Firstly, employing a highly dense global mesh would meticulously capture the intricacies of each section within the variable-thickness lattice. Although this method demands greater computational time for meshing and simulation, it effectively captures localized effects.</p>
            <p>Alternatively, for an isotropic material, a mesh featuring finite &#x201c;beam&#x201d; elements within each lattice segment is viable. While this approach forfeits the capacity to evaluate localized stresses, it ensures swift and accurate deformation predictions. However, it provides approximated values for internal stresses in the output. Despite this limitation, it serves as a valuable tool for swiftly evaluating results in designs primarily driven by stiffness considerations. In the present case, the first choice was made. The maximum element size of the new mesh was set to 0.1 mm, and a total of 1913956 elements corresponding to 427668 nodes were generated. The simulations of the same load cases illustrated above were performed.</p>
            <p>In both scenarios, zones registering von Mises stress peaks of approximately 14 MPa were identified. These peaks predominantly exhibit compressive stresses, which, in terms of the component&#x2019;s lifespan, do not pose significant concerns. This can be seen by looking at the following figures (
                <xref ref-type="fig" rid="f8">Figure 8</xref>, 
                <xref ref-type="fig" rid="f9">Figure 9</xref> and 
                <xref ref-type="fig" rid="f10">Figure 10</xref>).</p>
            <fig fig-type="figure" id="f8" orientation="portrait" position="float">
                <label>Figure 8. </label>
                <caption>
                    <title>Von Mises stress for the final structures, case 1 and 2.</title>
                </caption>
                <graphic id="gr8" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/158715/1baa990d-2f76-4458-8d75-6123bed780d8_figure8.gif"/>
            </fig>
            <fig fig-type="figure" id="f9" orientation="portrait" position="float">
                <label>Figure 9. </label>
                <caption>
                    <title>Map of local material displacements (in mm) analyzed in the first loading case and in the second on the modified cam.</title>
                </caption>
                <graphic id="gr9" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/158715/1baa990d-2f76-4458-8d75-6123bed780d8_figure9.gif"/>
            </fig>
            <fig fig-type="figure" id="f10" orientation="portrait" position="float">
                <label>Figure 10. </label>
                <caption>
                    <title>Maximum principal strain evaluated for the modiefied cam, case 1 and 2.</title>
                </caption>
                <graphic id="gr10" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/158715/1baa990d-2f76-4458-8d75-6123bed780d8_figure10.gif"/>
            </fig>
            <p>The conclusive simulation results of the component exhibit behavior aligning with the intended design characteristics. Subsequently, we initiated the mesh export in STL format for the 3D printing of the component. The exported mesh contained a total of 1,087,431 nodes. The requirement for an exceptionally dense mesh, surpassing that employed for the structural validation of the component, is attributed to the necessity for a high-resolution definition of the component&#x2019;s geometry. Such a dense mesh, comprised of numerous elements, is imperative for achieving detailed geometry resolution (
                <xref ref-type="bibr" rid="ref4">Bacciaglia 
                    <italic toggle="yes">et al.</italic>, 2021</xref>).</p>
            <sec id="sec2.1">
                <title>Printing strategy and settings</title>
                <p>The printer is an EPAX E10 4K mono using MSLA technology. The resin for the models is an EPAX hard and Tough clear that has the mechanical properties described in 
                    <xref ref-type="table" rid="T1">Table 1</xref>, stated by the manufacturer. The slicing software employed for preparing the model for printing is Lychee, version 1.7. Opting to print the cam in a vertical orientation was deliberate, as this position maintains superior resolution and mitigates warping issues beyond the symmetry plane. Manually placed supports serve a triple function: first, they support any disconnected &#x201c;islands&#x201d; of material within a specific layer; second, they prevent deformation caused by overhangs or material shrinkage; and third, they facilitate adequate detachment of the part from the FEP layer by applying sufficient force. To counteract shrinkage during both printing and the final curing phase, a 101% scaling was uniformly applied to the entire model directly within the slicer. This compensatory measure aims to address any potential dimensional alterations in the printed and cured component.</p>
                <p>Printing settings, according to the manufacturer specification, are set as shown in the table below (
                    <xref ref-type="table" rid="T2">Table 2</xref>). The high exposure value of the base layers (24 s) ensures the best possible adhesion to the aluminium printing platform. Normal layers, on the other hand, have a shorter exposure time (2.5 s), thus ensuring maximum detail resolution and avoiding overexposure that would lead to deformation and failure to meet prescribed dimensional tolerances. Slicing of the component was done in &#x201c;.ctb (v4)&#x201d; format, which allows vertical movement of the head in two different speeds. A low speed is therefore maintained in section 1, the one closest to the resin container, both in the ascent and approach phases. In contrast, the speed in section 2 is much higher. This makes it possible to avoid breakage or detachment of the part from the build plate in the phase of detachment from the FEP, and then to increase the speed when detachment is complete.</p>
                <table-wrap id="T2" orientation="portrait" position="float">
                    <label>Table 2. </label>
                    <caption>
                        <title>Printing settings for the manufacturing process.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Parameters</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Value</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Unit</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="3" rowspan="1" valign="middle">
                                    <bold>Burn in layers</bold>
                                </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Number of layers</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">4</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">/</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Exposure time</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">24</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">s</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Lift distance (1)</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">4</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">mm</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Lift distance (2)</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">3</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">mm</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Retraction distance (2)</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">4</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">mm</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Retraction distance (1)</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">3</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">mm</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Lift speed (1)</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">50</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">mm/min</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Lift speed (2)</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">150</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">mm/min</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Retract speed (2)</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">150</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">mm/min</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Retraction speed (1)</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">50</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">mm/min</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="3" rowspan="1" valign="middle">
                                    <bold>Normal layers</bold>
                                </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Exposure time</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">2.5</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">s</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Lift distance (1)</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">4</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">mm</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Lift distance (2)</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">3</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">mm</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Retraction distance (2)</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">4</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">mm</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Retraction distance (1)</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">3</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">mm</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Lift speed (1)</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">50</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">mm/min</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Lift speed (2)</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">150</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">mm/min</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Retract speed (2)</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">150</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">mm/min</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Retraction speed (1)</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">50</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">mm/min</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <p>After printing, the component is washed in IPA (isopropyl alcohol) through an ultrasonic cleaner. This allows the removal of any excess resin trapped in the component or inside the lattice geometry. The component underwent a 20-minute ultrasonic cleaning cycle, time suggested by the resin producer. Next, a manually support removal step was performed with the use of a little cutter. A careful visual inspection was performed in order to assess macro-defects such as failure of some parts of the structure, delamination or breakage occurring after the removal of the supports. The final step is the curing process to complete the polymerization of the part.</p>
                <p>Curing was performed using the XYZ printing 180 Multicure station. Following the manufacturer&#x2019;s directions, a curing time of 15 minutes was set with UV lights ranging between 385-405 nm at 120 W. After the curing phase, an additional visual inspection phase of the component is performed. The inspection is performed to check for macroscopic cracks or visible deformation occurred after the curing phase. Then, the components were 3D scanned (
                    <xref ref-type="fig" rid="f11">Figure 11</xref>) to assess if the dimensional tolerances of the component are within the needed for specific application.</p>
                <fig fig-type="figure" id="f11" orientation="portrait" position="float">
                    <label>Figure 11. </label>
                    <caption>
                        <title>Detail of the component and the supports needed for printing, on the left, and the final part printed in resin with supports still to be removed, on the right.</title>
                    </caption>
                    <graphic id="gr11" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/158715/1baa990d-2f76-4458-8d75-6123bed780d8_figure11.gif"/>
                </fig>
                <p>By evaluating the deviations between the Cad model and the scanned prototype surfaces, the validation of the latter was made possible. Alignment between the CAD model and the scan mesh was performed in a way that ensured minimal overall error on the gap between the two surfaces. In the areas characterized by larger deviations, the gap between the CAD model is still less than 0.1 mm, as seen in 
                    <xref ref-type="fig" rid="f12">Figure 12</xref>. The FARO Quantum M ScanArm was utilized for the scanning process. Scanners of this kind do not require markers placed on or around the component&#x2019;s surface. Manufacturers declare precision levels capable of ensuring an accuracy within 5 hundredths of a millimeter. This implies that from the scan, deviations from the actual surface of the component are expected to be locally within this specified range. The precision matches that of top-tier digital calipers, albeit restricted to measuring lengths, diameters, or simpler geometries.</p>
                <fig fig-type="figure" id="f12" orientation="portrait" position="float">
                    <label>Figure 12. </label>
                    <caption>
                        <title>Quality control on the final resin prototype.</title>
                    </caption>
                    <graphic id="gr12" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/158715/1baa990d-2f76-4458-8d75-6123bed780d8_figure12.gif"/>
                </fig>
                <p>The CAM were then assembled on the Progrip
                    <sup>&#x00ae;</sup> grip and subsequently used as can be seen from the following figures (
                    <xref ref-type="fig" rid="f13">Figure 13</xref> and 
                    <xref ref-type="fig" rid="f14">Figure 14</xref>).</p>
                <fig fig-type="figure" id="f13" orientation="portrait" position="float">
                    <label>Figure 13. </label>
                    <caption>
                        <title>Original cam.</title>
                    </caption>
                    <graphic id="gr13" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/158715/1baa990d-2f76-4458-8d75-6123bed780d8_figure13.gif"/>
                </fig>
                <fig fig-type="figure" id="f14" orientation="portrait" position="float">
                    <label>Figure 14. </label>
                    <caption>
                        <title>Mounted part on Progrip
                            <sup>&#x00ae;</sup> mod. : 708 grip.</title>
                    </caption>
                    <graphic id="gr14" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/158715/1baa990d-2f76-4458-8d75-6123bed780d8_figure14.gif"/>
                </fig>
                <p>As can be seen by comparing the two figures, the cam end angle has been modified to prevent the rider from over-twisting the wrist. At the same time, the lightening of the component allows for better lightness and management of acceleration by the rider due to the reduced moment of inertia of the new model. This difference is slight and difficult to notice but is evident to the experienced hand of the pilot.</p>
            </sec>
        </sec>
        <sec id="sec3" sec-type="conclusions">
            <title>Conclusions</title>
            <p>Thanks to the advantages offered by Additive Manufacturing and, in particular, by 3D printing combined with the use of &#x201c;lattice&#x201d; structures, it has been possible to create an optimized functional component. This component is able to guarantee the maximum feeling between motorbike and rider and to allow the maximum integration between the two. A workflow was therefore proposed that can be optimally followed not only for the optimisation of the specific component of this article but for any component designed with latex structures and realised in resin. Within the workflow there are multiple control steps that allow defects to be immediately identified and traced back to a specific stage. This makes it possible to identify the origin of the defect and act accordingly.</p>
            <p>Resin printing combined with new-generation resins has proven to be a mature technology for the production of functional components and not just prototypes. The final deformations of the object are small and within the imposed tolerances. It would be desirable in the future, especially in the case of components with higher tolerances, to be able to effectively simulate the printing process and thus predict the position of the substrates in order to minimize the deformation of the component and improve its final quality. Furthermore, a particularly straightforward type of internal infill was chosen to expedite the printing process (the application demanded short experimentation times within a sports and competitive context). Future research and experimentation activities in this field will focus on performance analyses of various structures to determine the optimal one in terms of stress resistance and printability.</p>
            <p>As far as &#x201c;lattice&#x201d; structures are concerned, these have been the subject of research as far back as the 1990s. Despite that they have only found a real possibility of application in the present day, thanks mainly to 3D printing technologies that allow great freedom in geometries. The possibility of applying &#x201c;lattice&#x201d; structures by combining them with a stress field or a deformation field and then modifying the thickness of the rafters that make up the cell according to a criterion greatly broadens the horizons towards increasingly optimized and high-performance structures.</p>
        </sec>
        <sec id="sec4">
            <title>Data availability</title>
            <p>All data underlying the results are available as part of the article and no additional source data are required.</p>
        </sec>
    </body>
    <back>
        <ref-list>
            <title>References</title>
            <ref id="ref1">
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Al-Ketan</surname>
                            <given-names>O</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Abu Al-Rub</surname>
                            <given-names>RK</given-names>
                        </name>
</person-group>:
                    <article-title>Multifunctional Mechanical Metamaterials Based on Triply Periodic Minimal Surface Lattices.</article-title>
                    <source>

                        <italic toggle="yes">Adv. Eng. Mater.</italic>
</source>
                    <year>2019</year>;<volume>21</volume>(<issue>10</issue>):<fpage>1900524</fpage>.
                    <pub-id pub-id-type="doi">10.1002/ADEM.201900524</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref2">
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Bacciaglia</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Ceruti</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Liverani</surname>
                            <given-names>A</given-names>
                        </name>
</person-group>:
                    <article-title>Photogrammetry and additive manufacturing based methodology for decentralized spare part production in automotive industry.</article-title>
                    <source>

                        <italic toggle="yes">Advances in Intelligent Systems and Computing, 1131 AISC.</italic>
</source>
                    <year>2020a</year>:<fpage>796</fpage>&#x2013;<lpage>802</lpage>.
                    <pub-id pub-id-type="doi">10.1007/978-3-030-39512-4_121/FIGURES/2</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref3">
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Bacciaglia</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Ceruti</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Liverani</surname>
                            <given-names>A</given-names>
                        </name>
</person-group>:
                    <article-title>Evaluation of 3D printed mouthpieces for musical instruments.</article-title>
                    <source>

                        <italic toggle="yes">Rapid Prototyp. J.</italic>
</source>
                    <year>2020b</year>;<volume>26</volume>(<issue>3</issue>):<fpage>577</fpage>&#x2013;<lpage>584</lpage>.
                    <pub-id pub-id-type="doi">10.1108/RPJ-07-2019-0187/FULL/XML</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref4">
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Bacciaglia</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Ceruti</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Liverani</surname>
                            <given-names>A</given-names>
                        </name>
</person-group>:
                    <article-title>Surface smoothing for topological optimized 3D models.</article-title>
                    <source>

                        <italic toggle="yes">Struct. Multidiscip. Optim.</italic>
</source>
                    <year>2021</year>;<volume>64</volume>(<issue>6</issue>):<fpage>3453</fpage>&#x2013;<lpage>3472</lpage>.
                    <pub-id pub-id-type="doi">10.1007/S00158-021-03027-6/TABLES/5</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref5">
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Croccolo</surname>
                            <given-names>D</given-names>
                        </name>

                        <name name-style="western">
                            <surname>De Agostinis</surname>
                            <given-names>M</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Fini</surname>
                            <given-names>S</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <source>

                        <italic toggle="yes">Influence of the interference level and of the assembly process on the shear strength of loctite 648 anaerobic adhesive.</italic>
</source>
                    <year>2019</year>;<volume>96</volume>(<issue>1&#x2013;4</issue>):<fpage>90</fpage>&#x2013;<lpage>112</lpage>.
                    <pub-id pub-id-type="doi">10.1080/00218464.2019.1681268</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref6">
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Deshpande</surname>
                            <given-names>VS</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Fleck</surname>
                            <given-names>NA</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Ashby</surname>
                            <given-names>MF</given-names>
                        </name>
</person-group>:
                    <article-title>Effective properties of the octet-truss lattice material.</article-title>
                    <source>

                        <italic toggle="yes">J. Mech. Phys. Solids.</italic>
</source>
                    <year>2001</year>;<volume>49</volume>(<issue>8</issue>):<fpage>1747</fpage>&#x2013;<lpage>1769</lpage>.
                    <pub-id pub-id-type="doi">10.1016/S0022-5096(01)00010-2</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref7">
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Plessis</surname>
                            <given-names>A</given-names>
                            <prefix>du</prefix>
                        </name>

                        <name name-style="western">
                            <surname>Yadroitsava</surname>
                            <given-names>I</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Yadroitsev</surname>
                            <given-names>I</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Numerical comparison of lattice unit cell designs for medical implants by additive manufacturing.</article-title>
                    <source>

                        <italic toggle="yes">Virtual Phys. Prototyp.</italic>
</source>
                    <year>2018</year>;<volume>13</volume>(<issue>4</issue>):<fpage>266</fpage>&#x2013;<lpage>281</lpage>.
                    <pub-id pub-id-type="doi">10.1080/17452759.2018.1491713</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref8">
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Fantini</surname>
                            <given-names>M</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Curto</surname>
                            <given-names>M</given-names>
                        </name>

                        <name name-style="western">
                            <surname>De Crescenzio</surname>
                            <given-names>F</given-names>
                        </name>
</person-group>:
                    <article-title>A method to design biomimetic scaffolds for bone tissue engineering based on Voronoi lattices.</article-title>
                    <source>

                        <italic toggle="yes">Virtual and Physical Prototyping.</italic>
</source>
                    <year>2016</year>;<volume>11</volume>(<issue>2</issue>):<fpage>77</fpage>&#x2013;<lpage>90</lpage>.
                    <pub-id pub-id-type="doi">10.1080/17452759.2016.1172301</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref9">
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Frizziero</surname>
                            <given-names>L</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Santi</surname>
                            <given-names>GM</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Leon-Cardenas</surname>
                            <given-names>C</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>An innovative and cost-advantage cad solution for cubitus varus surgical planning in children.</article-title>
                    <source>

                        <italic toggle="yes">Applied Sciences (Switzerland).</italic>
</source>
                    <year>2021a</year>;<volume>11</volume>(<issue>9</issue>).
                    <pub-id pub-id-type="doi">10.3390/APP11094057</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref10">
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Frizziero</surname>
                            <given-names>L</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Santi</surname>
                            <given-names>GM</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Leon-Cardenas</surname>
                            <given-names>C</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>In-House, Fast FDM Prototyping of a Custom Cutting Guide for a Lower-Risk Pediatric Femoral Osteotomy.</article-title>
                    <source>

                        <italic toggle="yes">Bioengineering.</italic>
</source>
                    <year>2021b</year>;<volume>8</volume>(<issue>6</issue>):<fpage>71</fpage>.
                    <pub-id pub-id-type="pmid">34073324</pub-id>
                    <pub-id pub-id-type="doi">10.3390/bioengineering8060071</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref11">
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Gandy</surname>
                            <given-names>PJF</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Bardhan</surname>
                            <given-names>S</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Mackay</surname>
                            <given-names>AL</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Nodal surface approximations to the P,G,D and I-WP triply periodic minimal surfaces.</article-title>
                    <source>

                        <italic toggle="yes">Chem. Phys. Lett.</italic>
</source>
                    <year>2001</year>;<volume>336</volume>(<issue>3&#x2013;4</issue>):<fpage>187</fpage>&#x2013;<lpage>195</lpage>.
                    <pub-id pub-id-type="doi">10.1016/S0009-2614(00)01418-4</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref12">
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Gibson</surname>
                            <given-names>LJ</given-names>
                        </name>
</person-group>:
                    <article-title>Modelling the mechanical behavior of cellular materials.</article-title>
                    <source>

                        <italic toggle="yes">Mater. Sci. Eng. A.</italic>
</source>
                    <year>1989</year>;<volume>110</volume>(<issue>C</issue>):<fpage>1</fpage>&#x2013;<lpage>36</lpage>.
                    <pub-id pub-id-type="doi">10.1016/0921-5093(89)90154-8</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref13">
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Ibhadode</surname>
                            <given-names>O</given-names>
                        </name>
</person-group>:
                    <article-title>Structural Design Strategies for the Production of Internal Combustion Engine Components by Additive Manufacturing: A Case Study of a Connecting Rod [Internet].</article-title>
                    <source>Renewable Energy - Recent Advances.</source>IntechOpen;<year>2023</year>.
                    <pub-id pub-id-type="doi">10.5772/intechopen.110371</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref14">
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Jung</surname>
                            <given-names>Y</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Chu</surname>
                            <given-names>KT</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Torquato</surname>
                            <given-names>S</given-names>
                        </name>
</person-group>:
                    <source>

                        <italic toggle="yes">A variational level set approach for surface area minimization of triply-periodic surfaces.</italic>
</source>
                    <year>2006</year>.
                    <pub-id pub-id-type="doi">10.1016/j.jcp.2006.10.007</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref15">
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Khaderi</surname>
                            <given-names>SN</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Deshpande</surname>
                            <given-names>VS</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Fleck</surname>
                            <given-names>NA</given-names>
                        </name>
</person-group>:
                    <article-title>The stiffness and strength of the gyroid lattice.</article-title>
                    <source>

                        <italic toggle="yes">Int. J. Solids Struct.</italic>
</source>
                    <year>2014</year>;<volume>51</volume>(<issue>23&#x2013;24</issue>):<fpage>3866</fpage>&#x2013;<lpage>3877</lpage>.
                    <pub-id pub-id-type="doi">10.1016/J.IJSOLSTR.2014.06.024</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref16">
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Khan</surname>
                            <given-names>KA</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Abu Al-Rub</surname>
                            <given-names>RK</given-names>
                        </name>
</person-group>:
                    <article-title>Time dependent response of architectured Neovius foams.</article-title>
                    <source>

                        <italic toggle="yes">Int. J. Mech. Sci.</italic>
</source>
                    <year>2017</year>;<volume>126</volume>:<fpage>106</fpage>&#x2013;<lpage>119</lpage>.
                    <pub-id pub-id-type="doi">10.1016/J.IJMECSCI.2017.03.017</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref17">
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Messner</surname>
                            <given-names>MC</given-names>
                        </name>
</person-group>:
                    <article-title>Optimal lattice-structured materials.</article-title>
                    <source>

                        <italic toggle="yes">J. Mech. Phys. Solids.</italic>
</source>
                    <year>2016</year>;<volume>96</volume>:<fpage>162</fpage>&#x2013;<lpage>183</lpage>.
                    <pub-id pub-id-type="doi">10.1016/J.JMPS.2016.07.010</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref18">
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Moon</surname>
                            <given-names>SK</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Tan</surname>
                            <given-names>YE</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Hwang</surname>
                            <given-names>J</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Application of 3D printing technology for designing light-weight unmanned aerial vehicle wing structures.</article-title>
                    <source>

                        <italic toggle="yes">Int. J. Precis. Eng. Manuf.-Green Tech.</italic>
</source>
                    <year>2015</year>;<volume>1</volume>(<issue>3</issue>):<fpage>223</fpage>&#x2013;<lpage>228</lpage>.
                    <pub-id pub-id-type="doi">10.1007/S40684-014-0028-X</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref19">
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Pan</surname>
                            <given-names>C</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Han</surname>
                            <given-names>Y</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Lu</surname>
                            <given-names>J</given-names>
                        </name>
</person-group>:
                    <article-title>Design and Optimization of Lattice Structures: A Review.</article-title>
                    <source>

                        <italic toggle="yes">Appl. Sci.</italic>
</source>
                    <year>2020</year>;<volume>10</volume>(<issue>18</issue>):<fpage>6374</fpage>.
                    <pub-id pub-id-type="doi">10.3390/APP10186374</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref20">
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Savio</surname>
                            <given-names>G</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Meneghello</surname>
                            <given-names>R</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Concheri</surname>
                            <given-names>G</given-names>
                        </name>
</person-group>:
                    <article-title>Design of variable thickness triply periodic surfaces for additive manufacturing.</article-title>
                    <source>

                        <italic toggle="yes">Prog. Addit. Manuf.</italic>
</source>
                    <year>2019</year>;<volume>4</volume>(<issue>3</issue>):<fpage>281</fpage>&#x2013;<lpage>290</lpage>.
                    <pub-id pub-id-type="doi">10.1007/S40964-019-00073-X/FIGURES/8</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref21">
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Shin</surname>
                            <given-names>J</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Kim</surname>
                            <given-names>S</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Jeong</surname>
                            <given-names>D</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Finite element analysis of Schwarz P surface pore geometries for tissue-engineered scaffolds.</article-title>
                    <source>

                        <italic toggle="yes">Math. Probl. Eng.</italic>
</source>
                    <year>2012</year>;<volume>2012</volume>:<fpage>1</fpage>&#x2013;<lpage>13</lpage>.
                    <pub-id pub-id-type="doi">10.1155/2012/694194</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref22">
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Tamburrino</surname>
                            <given-names>F</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Graziosi</surname>
                            <given-names>S</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Bordegoni</surname>
                            <given-names>M</given-names>
                        </name>
</person-group>:
                    <article-title>The design process of additively manufactured mesoscale lattice structures: A review.</article-title>
                    <source>

                        <italic toggle="yes">J. Comput. Inf. Sci. Eng.</italic>
</source>
                    <year>2018</year>;<volume>18</volume>(<issue>4</issue>)
                    <pub-id pub-id-type="doi">10.1115/1.4040131/369017</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref23">
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Tao</surname>
                            <given-names>W</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Leu</surname>
                            <given-names>MC</given-names>
                        </name>
</person-group>:
                    <article-title>Design of Lattice Structure for Additive Manufacturing.</article-title>
                    <source>

                        <italic toggle="yes">Proceedings of the 2016 International Symposium on Flexible Automation (2016, Cleveland, OH).</italic>
</source>
                    <year>2016</year>:<fpage>325</fpage>.
                    <pub-id pub-id-type="doi">10.1109/ISFA.2016.7790182</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref24">
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Totaro</surname>
                            <given-names>G</given-names>
                        </name>

                        <name name-style="western">
                            <surname>G&#x00fc;rdal</surname>
                            <given-names>Z</given-names>
                        </name>
</person-group>:
                    <article-title>Optimal design of composite lattice shell structures for aerospace applications.</article-title>
                    <source>

                        <italic toggle="yes">Aerosp. Sci. Technol.</italic>
</source>
                    <year>2009</year>;<volume>13</volume>(<issue>4&#x2013;5</issue>):<fpage>157</fpage>&#x2013;<lpage>164</lpage>.
                    <pub-id pub-id-type="doi">10.1016/J.AST.2008.09.001</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref25">
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Vasiliev</surname>
                            <given-names>VV</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Razin</surname>
                            <given-names>AF</given-names>
                        </name>
</person-group>:
                    <article-title>Anisogrid composite lattice structures for spacecraft and aircraft applications.</article-title>
                    <source>

                        <italic toggle="yes">Compos. Struct.</italic>
</source>
                    <year>2006</year>;<volume>76</volume>(<issue>1&#x2013;2</issue>):<fpage>182</fpage>&#x2013;<lpage>189</lpage>.
                    <pub-id pub-id-type="doi">10.1016/J.COMPSTRUCT.2006.06.025</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref26">
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Yin</surname>
                            <given-names>S</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Chen</surname>
                            <given-names>H</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Wu</surname>
                            <given-names>Y</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Introducing composite lattice core sandwich structure as an alternative proposal for engine hood.</article-title>
                    <source>

                        <italic toggle="yes">Compos. Struct.</italic>
</source>
                    <year>2018</year>;<volume>201</volume>:<fpage>131</fpage>&#x2013;<lpage>140</lpage>.
                    <pub-id pub-id-type="doi">10.1016/J.COMPSTRUCT.2018.06.038</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref27">
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Zhang</surname>
                            <given-names>J</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Huang</surname>
                            <given-names>H</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Liu</surname>
                            <given-names>G</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Stiffness and energy absorption of additive manufactured hybrid lattice structures.</article-title>
                    <source>

                        <italic toggle="yes">Virtual Phys. Prototyp.</italic>
</source>
                    <year>2021</year>;<volume>16</volume>(<issue>4</issue>):<fpage>428</fpage>&#x2013;<lpage>443</lpage>.
                    <pub-id pub-id-type="doi">10.1080/17452759.2021.1954405</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref28">
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Zhu</surname>
                            <given-names>JH</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Zhang</surname>
                            <given-names>WH</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Xia</surname>
                            <given-names>L</given-names>
                        </name>
</person-group>:
                    <article-title>Topology Optimization in Aircraft and Aerospace Structures Design.</article-title>
                    <source>

                        <italic toggle="yes">Arch. Comput. Methods Eng.</italic>
</source>
                    <year>2015</year>;<volume>23</volume>(<issue>4</issue>):<fpage>595</fpage>&#x2013;<lpage>622</lpage>.
                    <pub-id pub-id-type="doi">10.1007/S11831-015-9151-2</pub-id>
                </mixed-citation>
            </ref>
        </ref-list>
    </back>
    <sub-article article-type="reviewer-report" id="report226783">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.158715.r226783</article-id>
            <title-group>
                <article-title>Reviewer response for version 2</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Hamel</surname>
                        <given-names>Craig M.</given-names>
                    </name>
                    <xref ref-type="aff" rid="r226783a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0003-4086-9010</uri>
                </contrib>
                <aff id="r226783a1">
                    <label>1</label>Sandia National Laboratories, Albuquerque, Mexico</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>19</day>
                <month>1</month>
                <year>2024</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2024 Hamel CM</copyright-statement>
                <copyright-year>2024</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport226783" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.125184.2"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>The authors have addressed my comments sufficiently.</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Partly</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Not applicable</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Yes</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Reviewer Expertise:</p>
            <p>Additive manufacturing, Constitutive modeling</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.</p>
        </body>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report226782">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.158715.r226782</article-id>
            <title-group>
                <article-title>Reviewer response for version 2</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Ibhadode</surname>
                        <given-names>Osezua</given-names>
                    </name>
                    <xref ref-type="aff" rid="r226782a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0001-6030-3490</uri>
                </contrib>
                <aff id="r226782a1">
                    <label>1</label>Mechanical Engineering, University of Alberta, Edmonton, Alberta, Canada</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>16</day>
                <month>12</month>
                <year>2023</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2023 Ibhadode O</copyright-statement>
                <copyright-year>2023</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport226782" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.125184.2"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>I believe substantial improvements have been made to the manuscript according to my recommendations; I approve it for publication.</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Yes</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Not applicable</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Partly</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Yes</p>
            <p>Reviewer Expertise:</p>
            <p>Topology Optimization, Design for Additive Manufacturing, Lattice Structure Design, Multi-objective and Multiphysics Optimization.</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.</p>
        </body>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report178994">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.137463.r178994</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Hamel</surname>
                        <given-names>Craig M.</given-names>
                    </name>
                    <xref ref-type="aff" rid="r178994a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0003-4086-9010</uri>
                </contrib>
                <aff id="r178994a1">
                    <label>1</label>Sandia National Laboratories, Albuquerque, Mexico</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>28</day>
                <month>7</month>
                <year>2023</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2023 Hamel CM</copyright-statement>
                <copyright-year>2023</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport178994" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.125184.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>Review:</p>
            <p> This article describes an approach combining additive manufacturing, FEM, and topology optimization to create rider specific components for motorcycles. While an interesting application and fusion of these technologies, this reviewer found the article to be lacking in several regards that with some modifications can be published. The reviewer&#x2019;s recommendations are the following 
                <list list-type="order">
                    <list-item>
                        <p>The authors should closely check the paper for proper spelling and grammar. There were many locations in the article where a comma could greatly improve readability.</p>
                    </list-item>
                    <list-item>
                        <p>Figures 6 and 9 should have their labels or the figure caption modified to point out that the field being plotted is the displacement magnitude.</p>
                    </list-item>
                    <list-item>
                        <p>In Figure 10 the authors need to mention which principal strain component they are plotting. Is it the maximum, middle, or minimum principal strain component?</p>
                    </list-item>
                    <list-item>
                        <p>A schematic should be provided which shows the mechanism in function from the rider&#x2019;s hand to the cam. This would allow those who are not experts in the automotive industry to better follow the authors&#x2019; work.</p>
                    </list-item>
                    <list-item>
                        <p>It would also aid readers to understand what the design inputs from a rider specific perspective are. E.g., how do we need to modify design constraints for a rider with a weaker hand due to injury?</p>
                    </list-item>
                    <list-item>
                        <p>Details on the element formulation used in FEM simulations should be provided. The authors mentioned tetrahedral elements, but which tetrahedral element? Additionally, the authors should at least mention mesh convergence and show due diligence on why they choice the specific element size for the specific quantities of interest.</p>
                    </list-item>
                    <list-item>
                        <p>The authors do not appear to have considered additional lattice topologies. This addition to the paper would be greatly improve its appeal.</p>
                    </list-item>
                </list>
            </p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Partly</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Not applicable</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Yes</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Reviewer Expertise:</p>
            <p>Additive manufacturing, Constitutive modeling</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
        <sub-article article-type="response" id="comment10574-178994">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Freddi</surname>
                            <given-names>Marco</given-names>
                        </name>
                        <aff>University of Bologna, Italy</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>15</day>
                    <month>11</month>
                    <year>2023</year>
                </pub-date>
            </front-stub>
            <body>
                <p>Dear Reviewer,</p>
                <p> </p>
                <p> Firstly, thank you for your guidance. We have revised the spelling and grammar of the manuscript.</p>
                <p> </p>
                <p> Additional specifications have been incorporated into Figures 6 and 9 to facilitate a clearer understanding of the visuals. The same applies to point 3.</p>
                <p> </p>
                <p> In point 4, you will find a modified image in the manuscript, outlining the assembly of the cam on the handlebar and demonstrating its usage.</p>
                <p> </p>
                <p> Concerning point 5, we have provided enhanced details at various junctures in the manuscript (highlighted for your convenience).</p>
                <p> </p>
                <p> Further exploration of lattice topologies will be the subject of forthcoming works that we intend to publish on F1000 Research. Our focus here was to dedicate the manuscript to the methodology used in designing and manufacturing the component.</p>
                <p> </p>
                <p> Moreover, additional details on the Finite Element Method (FEM) have been added.</p>
                <p> </p>
                <p> Thank you for your time and consideration.</p>
                <p> </p>
                <p> Best regards.</p>
            </body>
        </sub-article>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report173091">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.137463.r173091</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Ibhadode</surname>
                        <given-names>Osezua</given-names>
                    </name>
                    <xref ref-type="aff" rid="r173091a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0001-6030-3490</uri>
                </contrib>
                <aff id="r173091a1">
                    <label>1</label>Mechanical Engineering, University of Alberta, Edmonton, Alberta, Canada</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>28</day>
                <month>7</month>
                <year>2023</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2023 Ibhadode O</copyright-statement>
                <copyright-year>2023</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport173091" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.125184.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>This work presents a stress-based lattice modeling strategy to redesign a gas cam to become lightweight and retain acceptable structural rigidity. While this design methodology is not entirely new, its application is fresh and should be interesting to the design community. Nonetheless, there are several important points to be addressed by the authors before the work can be accepted.&#x00a0; 
                <list list-type="order">
                    <list-item>
                        <p>Highlight the performance of the redesigned cam quantitatively compared to the original cam design.</p>
                    </list-item>
                    <list-item>
                        <p>I strongly recommend that you expand the literature mentioned in the introduction. I will suggest exploring at least 5 other related studies. For example, similar work is shown in DOI: 
                            <ext-link ext-link-type="uri" xlink:href="https://www.intechopen.com/online-first/86387">10.5772/intechopen.110371</ext-link>. Include this reference while highlighting the similarities and explain what is different or unique in your work.&#x00a0;</p>
                    </list-item>
                    <list-item>
                        <p>It is important to discuss more the original cam, essentially, its function as part of a larger assembly. I also did not find what material is used to make the original cam. Ensure more details about the original cam are included in the revised manuscript.</p>
                    </list-item>
                    <list-item>
                        <p>Highlight how you ended up with the design and non-design domains. What informed the decision to keep some regions as non-designable, also mention how you determined the sizes/thicknesses of these domains.</p>
                    </list-item>
                    <list-item>
                        <p>nTopology has officially changed its name to nTop. This should be reflected in your revised manuscript. You could also include a software reference.&#x00a0;</p>
                    </list-item>
                    <list-item>
                        <p>Was any mesh independence study done? If not, explain how the mesh parameters were chosen to uphold the accuracy of the stress analysis study.</p>
                    </list-item>
                    <list-item>
                        <p>In the penultimate row of Table 1, the first column should be "Density after curing".</p>
                    </list-item>
                    <list-item>
                        <p>The original gas CAM which is shown in Figure 13 was not numerically analyzed. It is pertinent to compare the stress and displacement results of the original CAM with the redesigned CAM. I strongly recommend this is done and the appropriate comparisons made. Check the work in DOI: 
                            <ext-link ext-link-type="uri" xlink:href="https://www.intechopen.com/online-first/86387">10.5772/intechopen.110371</ext-link>.&#x00a0;</p>
                    </list-item>
                    <list-item>
                        <p>What equipment was used to 3D scan the printed cam? Mention the manufacturer and model. Also briefly describe the 3D scanning process.&#x00a0;</p>
                    </list-item>
                    <list-item>
                        <p>In the conclusion, quantitative performance comparisons between the original and redesigned cam should be adequately highlighted.&#x00a0;</p>
                    </list-item>
                </list>
            </p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Yes</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Not applicable</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Partly</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Yes</p>
            <p>Reviewer Expertise:</p>
            <p>Topology Optimization, Design for Additive Manufacturing, Lattice Structure Design, Multi-objective and Multiphysics Optimization.</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
        <back>
            <ref-list>
                <title>References</title>
                <ref id="rep-ref-173091-1">
                    <label>1</label>
                    <mixed-citation publication-type="journal">
                        <person-group person-group-type="author"/>:
                        <article-title>Structural Design Strategies for the Production of Internal Combustion Engine Components by Additive Manufacturing: A Case Study of a Connecting Rod</article-title>.<year>2022</year>;
                        <elocation-id>10.5772/intechopen.110371</elocation-id>
                        <pub-id pub-id-type="doi">10.5772/intechopen.110371</pub-id>
                    </mixed-citation>
                </ref>
            </ref-list>
        </back>
        <sub-article article-type="response" id="comment10575-173091">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Freddi</surname>
                            <given-names>Marco</given-names>
                        </name>
                        <aff>University of Bologna, Italy</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>15</day>
                    <month>11</month>
                    <year>2023</year>
                </pub-date>
            </front-stub>
            <body>
                <p>Dear reviewer,</p>
                <p> </p>
                <p> The performance of the new cam has been prominently highlighted in the final paragraphs of the publication and in the conclusions, particularly concerning the angle of aperture and the reduction in the component's moment of inertia. However, I would like to emphasize that the article's focus lies more on the method rather than solely on the component itself, which serves as a case study example.</p>
                <p> </p>
                <p> We have included in the literature the work recommended by you, which could serve as a reference point for readers in comparing it with another case study. At the beginning of paragraph 2, you will find a more detailed description of the original component.</p>
                <p> </p>
                <p> Additionally, we have included a drawing created by us to better illustrate its geometries and functionalities. We have revised the name to 'NTop'.</p>
                <p> </p>
                <p> Furthermore, in point 4, we have provided improved explanations (all highlighted in the new document). The original cam was not analyzed simply because we do not have its CAD. Our model is new; it draws inspiration from the same cam but is not a redesign of the component itself.</p>
                <p> </p>
                <p> We have also added information regarding the scanning performed on the component.</p>
            </body>
        </sub-article>
    </sub-article>
</article>
