Wellens syndrome is characterized by specific ECG profiles in the precordial lead, especially in the T-wave segment, which is associated with critical stenosis of the proximal left anterior descending (LAD) coronary artery. ¹ The incidence rate is 10–15% of all patients with acute coronary syndrome. ² Moreover, the presence of coronary collateral circulation can change an ECG picture that should be an ST-elevated myocardial infarction due to total or near total occlusion of the left anterior descending artery, turning into an ECG picture of Wellens syndrome.

In this case, we present Wellens syndrome in acute total occlusion saved by collateral. Significant collateral circulation is believed to improve clinical outcomes, especially in patients with acute coronary syndrome.

A 57-year-old man presented at Dr. Soetomo General Hospital, Surabaya, Indonesia, with sudden chest pain. He had a history of uncontrolled type 2 diabetes mellitus, uncontrolled hypertension, hypercholesterolemia, and a recent history of angina three years prior without undergoing a revascularization procedure. There was no history of cocaine use. He was brought to the emergency department with acute onset of substernal chest pain and diaphoresis. The chest pain started two hours before he was brought to the emergency ward. His chest pain score was four on the visual analogue scale (VAS). Nitroglycerin was administrated then the patient's chest pain disappeared. On physical examination on the emergency ward, he was afebrile with a heart rate of 99, blood pressure of 170/100 mmHg, respiratory rate of 22 breaths per minute, and oxygen saturation of 95% in room air. He was overweight with a pained grunt and he occasionally clutched his chest. Physical examination was unremarkable.

Wellens ECG pattern is commonly found in a patient with total or near total occlusion in the proximal left anterior descending coronary artery. It is commonly associated with NSTE-ACS, followed by new onset angina CCS III-IV or crescendo angina, without increased cardiac markers. ⁶ The spontaneous transformation from Wellens type A ECG pattern into Wellens type B ECG pattern is a rare case. It reflects a pattern of electrocardiography (ECG) that sometimes changes due to occlusion and spontaneous reperfusion from the collateral coronary artery. Wellens type A and type B are particular for critical, proximal stenosis of the left anterior descending (LAD) coronary artery. ⁷ Criteria for diagnosing Wellens syndrome include all of the following ^{8 , 9} : •

Wellens type A describes a pattern of ECG that shows biphasic T wave in the lead V2–V4

In this case, the first ECG showed a biphasic T wave in lead V1–V4 (Wellens type A) and it was minimally elevated (<1 mm). After a few hours before the invasive procedure, the second ECG showed a change in ST-segment elevation of more than 1 mm. In this case, the patient's ECG and troponin level showed Wellens syndrome. However, after a few hours the patient's ECG showed changes, namely an increase in elevation in the ST segment (>1 mm). An abnormal T wave ischemic pattern may persist, remaining between hours to weeks, even when the patient is asymptomatic without chest pain. ⁷ T wave abnormalities can be normalized or evolved into ST-segment elevation in the symptomatic patient with Wellens syndrome. The mechanism responsible for these ECG findings is repolarization heterogeneity resulting from reperfusion of a briefly occluded LAD. This could explain the evolution of T-wave modifications. ^{10 , 11} In this case, there was complete occlusion in the middle LAD, but the patient received collateral artery supply from the RCA so that the ECG feature mimicked the critical occlusion picture in the proximal LAD.

The collateral of the coronary artery is classified into five grades. Collateral grade 0 reveals no flow between the collateral of the coronary artery. This condition can occur when several collateral arteries are visible yet not angiographically apparent at any other time. Collateral grade 1 flow reveals a barely apparent collateral coronary artery. Sometimes, there might be an unclear connection with the significant epicardial coronary artery. Collateral grade 2 flow reveals a moderately opaque collateral coronary artery but it was only present through 75% of the cardiac cycle. Collateral grade 3 flow reflects a well-opacified collateral coronary artery while the column of dye is well defined (i.e., >0.5 mm in diameter), but it was <0.7 mm wide throughout most of its length. Collateral grade 4 flow mimics collateral grade 3. The collateral is very well opacified, fills antegrade, and is very large. It was >0.7 mm in diameter throughout its length. ^{12 , 13}

The cardiac catheterization results found that a collateral artery originating from the right coronary artery (RCA) supplied the mid-distal LAD. Therefore the heart muscle that should have been severely damaged due to not getting blood supply from the LAD could still survive due to the presence of the collateral artery. Previous data has established that enough collaterals can prevent ischemia and directly induce spontaneous reperfusion in one-third of NSTE-ACS patients. Spontaneous reperfusion with well-developed coronary collateral circulation is associated with a better prognosis in cardiovascular mortality reduction. ¹⁴

In ischemic conditions, collateral circulations are a good predictor of prognosis. Collateral circulation may support cardiac function and decrease cardiac mortality and morbidity rate. Collateral circulations are inter arterial anastomoses that exist neonatally and grow more significant because of many mechanisms like cytokines and growth factors induced by shear stress and ischemia and pressure gradient changes. ¹⁵ The collateral circulation artery may appear several weeks after occlusion. ¹⁴

The patient felt that his treatment at the hospital was excellent and fast, especially when he felt chest pain. After the medication was taken, his chest pain gradually disappeared. The patient was also very grateful for the direct action of inserting a catheter into the heart in less than 24 hours. The patient hopes that the publication of cases of diseases like his will help paramedics handle them in the future.

This case shows Wellens syndrome, which can change into ST-elevation myocardial infarction. Wellens can also occur in the left anterior descending artery that is in total occlusion but gets its blood supply from a branch of the right coronary collateral artery. Based on this case report, an early invasive strategy is recommended, with favorable clinical outcomes.

Written informed consent for publication of their clinical details and clinical images was obtained from the patient.