Advanced materials foresight: research and innovation indicators related to advanced and smart nanomaterials

Background: Advanced materials are most likely to bring future economic, environmental and social benefits. At the same time, they may pose challenges regarding their safety and sustainability along the entire lifecycle. This needs to be timely addressed by the stakeholders (industry, research, policy, funding and regulatory bodies). As part of a larger foresight project, this study aimed to identify areas of scientific research and technological development related to advanced materials, in particular advanced nanomaterials and the sub-group of smart nanomaterials. The study identified and collected data to build relevant research and innovation indicators and analyse trends, impact and other implications. Methods: This study consisted of an iterative process including a documentation phase followed by the identification, description and development of a set of core research and innovation indicators regarding scientific publications, EU projects and patents. The data was extracted mainly from SCOPUS, CORDIS and PATSTAT databases using a predefined search string that included representative keywords. The trends, distributions and other aspects reflected in the final version of the indicators were analysed, e.g. the number of items in a period of time, geographical distribution, organisations involved, categories of journals, funding programmes, costs and technology areas. Results: Generally, for smart nanomaterials the data used represent around 3.5% of the advanced nanomaterials data, while for each field analysed, they represent 4.4% for publications, 13% for projects and 1.1% for patents. The study shows current trends for advanced nanomaterials at a top-level information that can be further extended with sub-indicators. Generally, the results indicated a significant growth in research into advanced nanomaterials, including smart nanomaterials, in the last decade, leading to an increased availability of information. Conclusion: These indicators identify trends regarding scientific and technological achievements and represent an important element when examining possible impacts on society and policy implications associated to these areas.


Policy context
The European Union (EU) has adopted interconnected legislation to avoid trade barriers and ensure free movement of goods and people within the EU.The European Commission (EC) continuously evaluates whether EU legislation is meeting the needs of citizens and business through the European Commission's regulatory fitness and performance (REFIT) programme. 1REFIT checks regulatory fitness and performance, aiming to ensure that EU legislation delivers results for citizens and businesses effectively, efficiently and at minimum cost, striving to make existing EU laws simpler and less burdensome to apply.Among other things, EU legislation aims to ensure that chemicals placed on the market, and the products in which they are incorporated, can be produced and used safely for humans and the environment.Two core pieces of legislation: the Regulations on Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) 2 and on Classification, Labelling and Packaging of substances and mixtures (CLP) 3 address safety of chemicals.A vision for the chemicals of the future is to ensure that they are inherently safe and sustainable. 4The latter requires, among others conditions, that they fit into a circular economy, 5 which is a concept aimed at minimising waste, reusing and recycling products, saving resources and preserving the environment.For the sake of regulatory preparedness, legislators desire to be able to predict the entry into the market of chemicals with tailor-made properties in order to understand if they would have any associated needs for updating the legislation and/or guidance related to safety and/or sustainability.

REVISED Amendments from Version 1
The following changes were performed to the article: -Improved readability.
-Revision of the introduction including clarifications regarding advanced materials definitions, terms and the objectives of the study.
-Figure 1 was updated, including additional information included in its caption.
-Revision of methodology section to clarify aspects especially related to data collection and analysis, and the use of different tools.
-Revision of results section to improve its comprehension.
-Revision of discussion, especially on the relevance of the indicators.
-Two additional references were added.
Any further responses from the reviewers can be found at the end of the article In order to achieve the goals set out in the Commission's European Green Deal, 6 the Commission published a Chemicals Strategy for Sustainability (CSS) towards a toxic-free environment. 4It is part of the EU's zero pollution ambition, 7 which is a key commitment of the European Green Deal, which is also driving a New Industrial Strategy for Europe 8 that promotes responsible design and development of chemicals, materials and products.Safe and sustainable chemicals and materials 9,10 can help to reach these policy goals. 11The Green Deal includes an action for boosting the investment and innovative capacity for production and use of chemicals that throughout their life cycle are safe and sustainable by design (SSbD).
One tool for predicting which chemicals will enter the market is a foresight study. 12Foresight studies explore the future of scientific and technological achievements and their potential impacts on society.They aim to identify the areas of scientific research and technological development that are most likely to bring about change and drive future economic, environmental and social benefits.Among others, foresight builds on indicators.An indicator is a quantitative or a qualitative measure derived from a series of observed facts that can reveal relative positions, e.g. at given regular intervals, and it can point to the direction of change across different units and through time. 13,14cording to the Commission's 2021 Strategic Foresight Report, 15 the EU is a strong player in terms of knowledge and innovation, providing almost 20% of the world's total research and development, publications and patenting activity.An example of the EU's strength is that it has the largest share of worldwide patent applications in advanced manufacturing technologies and the Internet of Things for mobility. 16The EU is a technological champion in advanced manufacturing and materials, with its industry delivering many critical enablers to global production lines, as well as a leader in future smart and sustainable mobility and low-carbon technologies. 15,17rough its financial instruments and research and innovation programmes the EC supports research into and development of advanced materials for applications, for example in energy, construction, mobility, health, agriculture and the electronics sectors to deliver the green transition. 4,8Regarding smart nanomaterials e.g."It is expected that future research activities in the European Union will investigate whether the current approach to safe-by-design covers the dynamic features of smart nanomaterials too and, if not, how to adapt it and provide manufacturers and regulators with the appropriate tools for its implementation.". 18Figure 1 illustrates how policy can steer the development of advanced materials towards safer alternatives and the associated tools required.
Thus, advanced materials are important drivers for the Green and Digital Transition, support the EU industrial recovery and can provide many economic, environmental and social benefits.However, as any other result of innovation, they may pose challenges (e.g.ensuring that they are safe and sustainable along their entire life cycle) that need to be timely addressed by regulators, in collaboration with other stakeholders.Some foresight regarding the kind of materials and areas of development of advanced materials seems appropriate as an initial step to anticipate those possible challenges.This should help both regulators and producers to be prepared to address them so that future advanced materials can deliver their maximum positive impacts to society.
In order to monitor progress, the EC intends to establish, in close cooperation with stakeholders, Key Performance Indicators (KPIs) to enable the measurement of the industrial transition towards the production of safe and sustainable chemicals as envisioned in the CSS. 4,19vanced and smart (nano)materials It is outside the scope of this paper to define advanced materials and it exploits existing resources, i.e., definitions of advanced materials currently agreed within the scientific community.These generated a set of representative terms, used later as keywords for extracting data.In general, advanced materials (AdMa) [20][21][22][23][24] mean materials that have novel or enhanced properties that improve performance in comparison to other materials already on the market (or the products and processes in which they are used) and represent a broad class of materials that include semiconductors, biomaterials and nanomaterials.They can boost the transition to greener technologies, as they have improved characteristics and enhanced performance (which may include reduced environmental impacts), thus contributing to a more sustainable future. 25The advanced materials "are associated with progressive technologies with the perspective to derive direct or indirect benefits in the form of highly specialised outcomes for multidisciplinary areas". 26The new or enhanced properties (e.g.specific or improved performance) of AdMa are often determined by a combination of their chemical composition, physical properties, specific structures and higher complexity, often involving specific production processes. 22Often today's advanced materials become tomorrow's standard materials, i.e. over time the currently new or improved properties and the resulting enhanced performance will become a common feature.
In the context of the OECD's Working Party on Manufactured Nanomaterials (WPMN) 27 Steering Group on AdMa, they are understood as"materials that are rationally designed to have new or enhanced properties, and/or have targeted or enhanced structural features with the objective to achieve specific or improved functional performance.This includes both new emerging manufactured materials, and materials that are manufactured from traditional materials.This also includes materials from innovative manufacturing processes, such as bottom-up approaches, that enable the creation of targeted structures from starting materials.It is acknowledged that what are considered to be AdMa will change with time". 22ny sectors and applications rely on AdMa as the key to providing better solutions, including applications in safety and sustainability such as healthcare & medicine, construction, energy, transportation, home & personal care, packaging, agriculture, textiles, electronic appliances. 28,29The "Materials 2030 Manifesto" presents nine selected innovation markets and considers the European Green Deal and other policies that aim to create new value-chains.
It was proposed 30 that categorisation, or classification, of AdMa is possible taking into consideration: Functionality: active materials (smart, responsive, multifunctional, adaptive); Figure 1.Illustration of the main policy areas (green) that steer the development of advanced materials (blue) and relevant tools (red).The second layer of hexagons (red and blue hexagons) represent different, linked actions, systems and activities that may have a role in the overall implementation of the policy goals.For the EU Green Deal (green hexagons), several strategies and actions closely linked to the research & innovation or application of advanced materials are included, such as the chemicals strategy for sustainability, European industrial and farm to fork strategies, circular economy and zero pollution action plans and the climate neutrality goal.The advanced materials (blue hexagons) central hexagon is completed with several characteristics related with their sustainability (e.g.safe, sustainable, functional, cost effective), as well as with their acceptance by the consumers and the fulfilment of the current regulations.Finally, tools and data such as an approach for SSbD, risk assessment and life cycle assessment methods supported by FAIR data principles and test guidelines, tools for improving the regulatory anticipation (regulatory preparedness), are needed in order to support their development aligned with the policy ambitions.
Since the term advanced material is not univocally defined, the study mentioned above also aimed to characterise the use of the term 'advanced material' to obtain a reasonable distinction of advanced materials from other types of materials.Also, a set of criteria was described that could be applied to assess the 'relevancy of advanced materials'.The proposed relevance assessment should allow the prioritisation of measures, e.g. with regard to the chemical safety.The four dimensions proposed for the relevance assessment comprise: i) scientific (e.g.novelty of properties or the novelty of scale or combination of properties that advanced materials may have), ii) economic and technical (e.g.their potential impact on technology development), iii) hazard and risk (e.g.effect thresholds of different endpoints by exposure levels) and iv) regulatory dimension (e.g.requirements for the generation and assessment of information on hazards and exposures as well as for the assessment of risks, coverage by the current legislation definitions and scope).In addition, a first description of identified advanced material clusters was performed.The outcomes of this analysis were presented in factsheets for each material, 31 which provide an overview of the characteristic properties of the identified advanced materials along with notes on the application range and potential risks and their regulatory status, as far as it can be anticipated.
Smart materials are materials that change their critical (functional) properties during use and activate specific functions upon exposure to external stimuli, which may come from their surroundings, for example a change in temperature, pH, light or contact with enzymes, to produce a dynamic and at times reversible change. 32Examples include sensors and targeted delivery systems (or carriers), which are already used in medical products, cosmetics and electronics, and furthermore R&D (research and development) applications are under development for e.g.agriculture, food, and packaging. 33An overview of the different types of smart materials available is provided in the 'Smart Materials Books Series' published by the Royal Society of Chemistry 34 since 2012.Currently it is a collection of forty-three (43) books, including ten book titles referring to nanomaterials.

Study objectives
The aim of this project, as part of a larger foresight study, is to identify areas of scientific research and technological development related to advanced materials.Of particular interest are advanced nanomaterials and the sub-group smart nanomaterials (without addressing specific components of these materials) that are most likely to bring changes and drive economic, environmental and social development and benefits for the future.The study should lead to insights into trends of future applications and support the anticipation of possible regulatory challenges, and several players (e.g.industry, policy makers, funding bodies, researchers) could equally benefit from these outcomes.
This study identifies and collects data in order to firstly build relevant indicators, and secondly to use the indicators to analyse the trends, impact and other implications, see Figure 2.This study addresses the objectives below sequentially:  (2) Identifying trends and their drivers by analysing scientific publications, projects and patents on advanced nanomaterials, in an attempt to look into the future of scientific and technological achievements for advanced nanomaterials; (3) Pave the way for further evaluations of possible impacts on society and policy implications associated to advanced nanomaterials.
In order to achieve these objectives, several key questions need to be answered, e.g.what are the current trends related to the development of advanced nanomaterials, which are the dominant sectors, organisations and countries that develop advanced materials, or what are the (current or future) policy actions that aim to resolve upcoming challenges related to the advanced nanomaterials?

Methods
In order to achieve the goals of the study, a methodology for creating indicators was established.As a starting point, the study analysed relevant policy documents, especially those related to the European Green Deal 6 and its priorities, in order to identify some of the already defined directions towards safe and sustainable advanced materials.The study then examined and analysed research and innovation trends (e.g.publications, projects and patents) in these areas in relation to the European policies or legislation.
The methodology applied to establish research and innovation indicators related to advanced (nano) materials is described below.It consists of an iterative process that involves a background analysis of policy documents in the context of the topics covered by the study (e.g.advanced materials, advanced nanomaterials and smart nanomaterials) and a preliminary collection of information.Once the context is established, the methodology includes inital identification and definition of indicators.Further development of indicators involves data collection and analysis, a process that includes definition of the keywords for data search as a first step and then several tools for data extraction and analysis from databases are applied.The methodology presented can be applied to any (sub) group of materials, for example smart nanomaterials, multicomponent nanomaterials, etc. by defining first an appropriate set of keywords to be included in the search strings.
Following the analysis of relevant policy and technical documents, a list of keywords and the desired indicators were created.This was an iterative process that aimed to identify, describe and collect data that is used to analyse trends and perspectives for advanced nanomaterials.

Background analysis and preliminary information collection
Besides the analysis of specific technical reports on advanced materials, the methodology consisted also of identification and analysis of several policy documents, foremost the European Green Deal policy documents (e.g.EC Communications regarding the EU Green Deal, the new Industrial Strategy for Europe, the new Circular Economy Action Plan, the Farm to Fork Strategy and the Chemicals Strategy for Sustainability).This preparatory phase generated a preliminary list of keywords.Therefore, the set of European Green Deal policy documents, 4-8,35,36 described in the introduction, were consulted and analysed in order to refine the objectives of the study, as well as to support the keywords definition for developing indicators, as shown below.The analysis was performed, first by extraction of terms (words) and their frequency used in these policy documents, using KNIME, a free and open-source tool. 37The terms related to the materials, sectors, safety and sustainability or regulation and policy (about 190 terms) were then selected and used to further refine and enrich the set of keywords for the R&I indicators data collection.The analysis included also the ranking of these terms based on their frequency in the policy documents (data not shown).
This background analysis was complemented (and validated) by the application of open access tool Semantic Text Analyser (SeTA) "the information retrieval tool for policy makers". 38SeTA applies advanced text analysis techniques to large document collections (e.g. from EUR-Lex, CORDIS, Data.europa.eu,Publications Office of the European Union), helping policy analysts to understand the concepts (defined by keywords, expressions and terms which are similar or related at the semantic level) expressed in thousands of documents and to visualise the relationships between these concepts and their development over time. 39For the current study, the tool was useful for automatically analysing the occurrence of several terms, such as advanced nanomaterials (see Figure 3 generated using SeTA tool), advanced materials or smart materials, which are already indexed in the SeTA database.Please note that some terms e.g.new materials, biomaterials, functional materials, innovative materials, novel materials, nanostructured materials, composite materials, nanotechnology, nanostructured and composites, were common to all three areas mentioned above.These results were used to further refine the list keywords to be used for the indicators.

Identification and definition of indicators
In this step a preliminary list of indicators was prepared starting from terms identified by analysing the policy documents as described above.Subsequently, further analyses of their relevance and adequacy to the current study were carried out for the selection of provisional indicators that fit the purpose of the study.Their relevance to the advanced nanomaterials areas, as well as their ability to capture temporal, sectorial and/or geographical trends were considered, as briefly described in the following.
After the preliminary analysis, the fields (i.e.publications, projects, patents) to be searched in the study were defined and linked to advanced nanomaterials, including also a focus on smart nanomaterials.
Then an initial list of core indicators relevant for the current study was defined which resulted from the investigation of research and innovation resources within the selected fields of scientific publications, EU projects and patents (Figure 4).This was an iterative step, in which a brief description regarding the indicators' title, relevance, data and possible subindicators was developed.The proposed sub-indicators focused on yearly trends, geographical distribution, organisations involved, journal categories for publications, costs of projects, keywords, etc.

Data collection and analysis
In this step the extraction of data from public databases (SCOPUS, CORDIS, PATSTAT and Data.europa.eu)using automatic data mining tools and analysis were performed using Tools for Innovation Monitoring (TIM).TIM is a tool, which is developed by the EC' Joint Research Centre (JRC), and it regularly downloads the documents included in the above databases for further data mining.The data mining process extracts documents based on user-defined keywords combined in a search string.During the data mining process both the list of keywords and the search strings used for data collection were also refined.The collection of data, namely the number of publications, projects, etc., was performed using the automatic tool TIM and based on the search strings, see below.No manual (reviewer) screening was performed.

Definition of keywords
The definition of keywords was based on an i) analysis of scientific/technical reports on advanced and smart (nano) materials, ii) analysis of policy documents, as well as iii) the use of automatic tools for text analysis, as described above.
A set of keywords was defined in order to build comprehensive search strings and further use them to extract the data from the database.The set of keywords cover the description of advanced (nano) materials (mainly functional and structural descriptors), including few very specific descriptors for smart nanomaterials, see Table 1.
The strings used for the searches were created so that the data extracted includes a combination of nanomaterials-related terms and the "advanced" descriptors, see Table 1.Additional filters were applied, depending on the specificity of the indicator and data required (e.g.data only on publications, projects or patents), timelines (e.g.data only between 2011 and 2020 for publications) or type of applications.The Boolean operators AND, OR and NOT were used to combine them.The final strings applied for each case are shown in the results section, together with the analysis performed.
For nanomaterials-related terms, several options were tested during the study iterations.For example, the addition of other nano-related descriptors generated very large datasets, and adding the terms "nano" or "nanoparticle" resulted in more than 400 000 results for publications.The search using "nano*" generated more than 800 000 results because the use of wildcard '*' generated data on all possible combinations of nano, and therefore gave less specific results.Most likely, the different options have an impact both on the amount and relevance of the data collected, and thus also on the specificity of the indicators.Finally, in order to generate a highly relevant set of results, which is representative for the topic covered by the study only the terms "nanoform" and "nanomaterial" were used in the final search string.In addition, by default TIM applies a stemming 40 process to the search terms entered by the user, in order to widen the set of matched documents (e.g. the term "technology" will match both "technology" and "technologies").
Furthermore, a set of keywords to cover the uses of these types of advanced materials were defined.Without being complete, this list, which is based on the examples of applications described previously 31 with further additions, intends to allow the analysis and extraction of a representative set of data for the areas and sectors which use the advanced nanomaterials.[32][33][34][35][36] Data extraction and analysis Based on the keywords, the search strings were defined for each individual indicator and used in the search engine for data extraction.The main tool used for data extraction was the TIM Technology Editor 41 that facilitates the access to data related to science and innovation.TIM allows to create and visualise datasets about specific technological issues from several sources, thus overcoming the need to access the specific databases one-by-one and manually combine the search results.The search was performed in the fields title, abstract and author keywords (except patents and EU funded projects that do not have author keywords) 40 of the documents, while the automatic keywords were generated by TIM, which attributed a variable number of words (10-15) to each document.The information about countries and organisations is retrieved from the affiliation of authors, applicants of patents and participants in EU projects.For the latter, the datamining tool uses the public information displayed in CORDIS and listed under the 'Fact Sheet' of the granted EU projects (i.e.title and abstract of the projects).In our study, TIM brought together datasets (exported as.xlsx files) from different sources regarding patents, scientific publications and EU grants: 1) peer-reviewed scientific publications from SCOPUS, 2) worldwide patent applications from PATSTAT and 3) projects funded by the EU's framework programmes for research and innovation (FP5 to Horizon 2020 [H2020]) from CORDIS, the EC's Community Research and Development Information Service.For the latter, additional data files with detailed information on FP5, FP6, FP7 and H2020 projects were extracted directly from the European data portal and used for analysis, especially regarding the costs of the projects.The exact strings applied are listed in Table 2.For the purpose of reproducibility, as an alternative to the TIM Technology Editor (used in this study) users can access "TIM Open Access".This is a version of TIM without restrictions and that allows users to perform searches and analyses on Open Access data.Therefore, it currently offers access to publications from Semantic Scholar, worldwide patent applications from PATSTAT, and projects EU funded projects from CORDIS.In addition, the same searches can be done in each of the databases separately, but the results would then need to be combined manually.TIM facilitates the extraction of all together and the visualisation.Except Scopus, all are open access.(included also in the list above, as advanced materials descriptors)

Nanomaterials nanoform nanomaterial
The creation of the final version of the indicators followed the above process and workflow (Figure 5) including some iterative refinement steps.First the collection of data using TIM was performed based on keywords related to advanced (including smart) nanomaterials description as well as keywords related to the application of these materials.The resulting data was analysed by looking at various aspects, like trends, distributions, and finally, the indicators were developed, including selecting how to visualise and report.The analysis included several aspects (e.g. for publications) and included indicators such as yearly distributions, categories of journals (as defined in the SCOPUS Subject Areas), author keywords or geographical distribution; for EU funded projects the analysis included aspects such as yearly distribution, value of projects, geographical distribution (e.g.countries, organisations); for patents the analysis looked into the yearly distribution, technology sub-areas or geographical distribution.
The figures included in the Results section were created with Microsoft Excel, while the maps were created with MapChart using the data extracted with the method presented above.

Results
The final search strings in TIM for "advanced nanomaterials" and for "smart nanomaterials" (see Table 2) and the data generated (from 1996 until the end of 2021) (Figure 6) were used as a starting point for the detailed analyses and to create the indicators for the three major areas screened in this study, i.e. scientific publications, EU funded projects and patents (Table 3).Additional fields (e.g.timeframes, classes or topics) were added to these basic search strings, depending on the specificity of the analysis and the desired indicator.Generally, 'node size' data from TIM datasets was used for the analysis that represent the number of results (e.g.number of documents) for that specific indicator.In this section, the results for advanced nanomaterials, including smart nanomaterials (ca.3.5% of the identified items for advanced nanomaterials), are analysed.In some cases, a specific evaluation of smart nanomaterials data was also included.
Figure 6 depicts the total number of documents per year for EU projects, patents and publications (articles, reviews, book chapters and conference proceedings) for advanced nanomaterials and smart nanomaterials (bottom); the extraction was performed with TIM and the search strings are indicated in Table 2.
As seen from Figure 6 (top) for advanced materials there is a steady increase in publications from 2001 (63 articles) to 2021 (more than 6200 articles), and with the rise in shared knowledge also the number of reviews increases.The book chapters appear from 2008 onwards and fluctuate a bit; they represent 5% of the total publications.The annual number of conference documents have remained at a fairly stable level; relatively they represent 7% of the total number of documents.The patents steadily increase from 6 in 2001 to around 500 in 2019 and then seem to fall again; this decrease may reflect the time needed to grant patents.The EU projects represent the number of projects that the EU has (co) funded via its research programmes and the year that the project started; the number of projects increases constantly until 2011 followed by a stable number of projects per year with an average of ~40 projects/year.A detailed analysis of the data collected for the three areas is presented in the sections below.

Publications
The information extracted from SCOPUS using TIM covers data for the period 2012 until 2021 and includes peerreviewed articles (70 %), reviews (18%), book chapters (6%) and conference proceedings (6%) addressing advanced nanomaterials; the percentages is the relative distribution of the publication categories.However, for simplicity, in most of the indicators below, we have merged this data in one item called 'Publications', unless otherwise stated.Overall, in this period there are 45,687 publications on advanced nanomaterials, of which 2,041 (4.4%) refer to smart nanomaterials.The final search string used for this search is shown in Table 2.
The extracted publications were analysed with regard to annual number of publications, see Figure 7.As expected, a significant increase in number of yearly publications was seen both for advanced materials (2012 = 1943 publications to 2021 = 7569 publications, i.e. an increase of 390 %) as well as for the sub-field smart nanomaterials (2012 = 67 publications to 2021 = 415 publications i.e. an increase of >600%).
When comparing with the publications on nanomaterials (data not shown), the trend is similar for the period analysed.
The total number of publications on advanced nanomaterials (45,687) represent 56% of the total number of publications on nanomaterials (81,653) [1].Interestingly, this percentage increased constantly from 47% in 2012 to 58-59% after 2018.For the relative occurrence of the types of publications (articles, books, etc.), there are no significant differences between nanomaterials and advanced nanomaterials.Analysing how the publications on advanced nanomaterials are distributed over different categories of journals reveals the following pattern, see Figure 8, which shows the top thirty categories of journals ranked according to the number of publications and including the time distribution from 2012 to 2021.Material science and engineering are very well represented over the whole period, reflecting research into developing advanced nanomaterials and into understanding the properties and possible uses of them.Also, chemistry and surface chemistry are well represented, indicating that possibly the greater reactivity of nanosized materials is a sought-after property, this is supported by the appearance of Catalysis among these journal categories.These first categories are followed by journals from the biotechnology and bioengineering areas.Interestingly there are categories of journals (e.g.Pollution, Process Chemistry and Technology) in which the publications were listed more recently only (2021), while for other categories (e.g.Metals and Alloys, Biochemistry, Genetics and Molecular Biology, or Surfaces and Interfaces) there are no publications listed in the last years two years analysed (2020-2021).It should be noted that one journal may be assigned to more than one category (as predefined in SCOPUS Subject Areas), therefore the publications could also be in one or more categories.An analysis of the most frequently used keywords is presented in Figure 9.It can be observed that most of the frequent terms refer to the material type (e.g.nanomaterials, nanoparticles, nanocomposites, carbon nanotube, graphene, polymer), to the functionality or specific property (e.g.drug delivery, stimulus response, self assembly, bio sensor, controlled release, mesoporous silica) or more general terms such as nanomedicine, nano technology, smart/smart material.
The worldwide geographical distribution of publications on advanced nanomaterials for the top 24 countries and the EU (Figure 10) shows that China is the country that has the highest number of publications (16,693), followed by the USA (8,793).The region of the EU is in between with 12,213 publications.In addition to the bar chart, the map inset of the EU illustrates the level of publications on advanced nanomaterials by the EU member states.

Projects
The data on projects funded under the European framework programmes (FP5, FP6, FP7 and Horizon 2020) covering the period 1998 to 2021 was extracted from the CORDIS database using TIM, and 563 projects on advanced nanomaterials were identified, of which 77 (13.6%) are related to smart nanomaterials.The search string used is shown in Table 2, while the distribution of projects per year and framework programmes are illustrated in Figure 11 and Figure 12.A significant increase in both number of projects and available funding is observed in the period 1999 (FP5) to 2020 (Horizon 2020).Furthermore, also the number of funded projects studying smart nanomaterials has increased from an average of 1 project per year in FP5 to 7 projects per year in Horizon 2020.As seen from Figure 11 the number of EU-funded projects has remained rather constant in the period 2011 to 2021.However, the project funding increased from €464 million under FP7 (2007 to 2013) to €589 million under H2020 (2014 to 2020), or in other words from €66.3 million/year to €84.1 million/year; see Figure 12.
Regarding the geographical distribution among EU member states ( Figure 13) it can be seen that 26 of the 27 EU member states participate to the projects, and that the large member states participate to more projects than the smaller ones, and that the old member states are more frequently involved in projects than the newer member states.The figure is based on TIM's automatic filter for EU countries and reflect the situation at the moment when the data was extracted.The analysis looked in more detail in order to show the participation of other countries in EU-funded projects through their organisations (e.g.former EU Member States or associated countries to the Horizon Framework Programme).Regarding the organisations participating in the EU funded projects (Figure 14), the old member states (including the former member, the UK which has 7 of the top-25 institutions) or associated countries to the Horizon Framework Programme (e.g.Switzerland) are represented, whereas none of the newer member states have yet institutions among the 25 most frequent ones.

Patents
The data on patents was extracted from PATSTAT using TIM and 3,428 existing patents on advanced nanomaterials were identified, of which 37 (1%) are related to smart nanomaterials.The search string used to extract the patents is shown in Table 2.
When analysing the number of patents awarded for advanced nanomaterials per year in the period 2011 to 2021 (Figure 15) there is a significant increase between 2011 and 2018 and a slight decrease in 2019-2020, which may just reflect the time that it takes to grant a patent and the delayed publication online (most evident for 2021).The first patent on smart nanomaterials was granted in 2007, and until 2013 at a maximum 1 patent per year was granted in this area, in 2014 two patents were granted, and afterwards 5 or more patents were granted each year.The small, but increasing, number of patents for smart nanomaterials may indicate that in the future, as this technology matures, more patents will be applied for and granted.9][50] These applications are still at the experimental research phase, but for agricultural applications they are clearly moving towards being the new way of dosing, in a timely manner and exactly needed amounts, essential nutrients and fertiliser as well as chemicals protecting plants against stressors.For medical applications smart nanomaterials are perceived for example as a future way of delivering medicine within the body to the precise location where it is needed.It is challenging to develop such applications into fully functional ones and time is required to go from identifying the concept to being able to patent it.
According to the International Patent Classification (IPC) 51 and USPTO Classification, 52 there are several areas of technology to which patents on advanced nanomaterials, including smart nanomaterials, pertain (Table 4).An analysis (not illustrated) of the technology areas of patents on 'advanced nanomaterials' versus the first year of using that technology area showed that in the period 1996 to 2021 the technology areas grew from 14 (in 1996) to 100 (in 2020), which is an indication of the uptake of advanced nanomaterials across innovative industrial applications.In the period of 1996 to 1999 the same 14 technology areas were considered, and more technology areas were used, adding between 495 patents (technology area applied since year 2000) and 20 patents (technology area applied since year 2007) to the number of patents granted.The indicators below (Figure 16) shows the most frequent technology sub-areas to which the patents were assigned, as well as the geographical distribution of patents on advanced nanomaterials (Figure 17).

Key research and innovation indicators
Current trends related to the advanced nanomaterials The presented analysis aimed to build indicators for advanced materials allowing to identify areas of growth.Figure 18 below illustrates the top level of information extracted by the analysis.Based on trend analysis of publications, projects  and patents, and applying a set of keywords identified through iterative analysis of policy documents, we gained an overview of the overall number of publications and their yearly distribution within each category (see Table 2), as well as their geographical distribution (see Figure 10).For publications, we identified the most frequently involved countries  worldwide (Figure 10).For the EU, we identified the number of publications on advanced nanomaterials per EU member state, the participation of each EU member state for projects (see Figure 13), as well as the top 25 organisations participating in EU projects (see Figure 14) related to advanced nanomaterials, which include organisations based in Switzerland (which is associated to the EU research programme) and the UK (which was deeply involved before Brexit in 2020).For publications only and the categories of journals in which they appeared see Figure 8.For the projects, the analysis focussed on the EU, and we elucidated information on the framework programmes and the costs of the projects (Figure 12).The analysis of the patents provided information on the technology areas in which new patents were granted.
According to the 'Science, research and innovation performance of the EU 2020', 16 the EU accounts for about one fifth of the world's R&D, publications and patents.As illustrated by the outcomes of the analysis of scientific publications,  projects and patents on advanced nanomaterials, there has been a significant growth in research into advanced nanomaterials, including smart nanomaterials, in the period of 2012 to 2021 leading to an increased availability of information; see e.g. Figure 7 'Scientific publications' cover peer-reviewed articles, reviews, book chapters and conference proceedings.EU's funding schemes have increasingly supported research into advanced nanomaterials, including smart nanomaterials, see e.g. Figure 11; this in turn has contributed to increasing the number of scientific publications originating from within the EU.Also, the number of patents granted per year has increased significantly in the 10-year period analysed as shown in Figure 15.
Based on the information presented above it is evident that in the period 2011 to 2021 the number of scientific publications and patents have increased significantly, whereas the increase in the number of EU-funded projects has been less notable.However, the project funding increased from €464 million under FP7 (2007 to 2013) to €589 million under H2020 (2014 to 2020), or in other words from €66.3 million/year to €84.1 million/year (see Figure 12).Hence, on average each project would be bigger under H2020 than under FP7.

Relevancy of indicators
These indicators would lead to identification of trends of future scientific and technological achievements in the area of advanced nanomaterials, which in turn would be one information element when examining possible impacts on society and policy implications associated to these areas.Often new technology matures and evolves from being a new research field to becoming applied science, 53 and products containing the technology are becoming available also to the general public.Thus, taken collectively the indicators for advanced materials reflect that today's advanced material is tomorrow's standard.However, the indicators in general but also those proposed here should be seen as a dynamic tool, as the input data may change every day (e.g. when new articles are published) but also regarding the keywords applied in the search queries to select the input data.As described in the methodology section, the identification of both keywords and indicators was an iterative processes that involved analysis of relevant EU policy documents and research and innovation trends (e.g.publications, projects and patents).Thus, it is assumed that the keywords used in this study are considered as representative terms for the area of advanced nanomaterials and the indicators proposed reflect the search string applied.
As new descriptions will be available for advanced nanomaterials, they can be added to the list or other terms can be withdrawn from the string.
To achieve these, more detailed analyses can be performed in order to look closer at and analyse, for example the distribution of advanced nanomaterials per sectors (agriculture, construction, electronics, energy, environment, medicine, biotechnology, etc.), specific applications and use of advanced nanomaterials (fertilisers, paintings, cosmetics, packaging, textiles, bioelectronics, sensors, batteries, solar cells, water treatment, biomarkers, coatings, drug carriers, tissue engineering, 3D printing, optics, etc.), most visible types of advanced nanomaterials (frequently used, characterised, etc.), new (smart) materials and applications that are at R&D stage and may soon be placed on the market, production and consumption patterns, online searching trends by the general public, economic and social impacts, or educational and training programmes related to the area of advanced (nano) materials.
As mentioned, such indicators would need periodical updating of the input data and their timelines in order to maintain their relevance.As the description or definition of advanced materials might change over time, any indicator needs to be a dynamic tool being able to capture new developments in this area.

Future of scientific and technological achievements in the area of advanced nanomaterials
The methodology used in the study by Giese et al. 2020 30 for identifying publications containing keywords on advanced materials included searching with a set of keywords in the Web of Science Core Collection 54 and extracting the data published between 2000 and 2018.The following terms were identified and used for characterising materials regarding their functionality, structure and manufacturing processes: Functionality: "active materials", "smart materials", "functional materials", "multifunctional materials" and "adaptive materials"; Structure: "structural materials", "structured materials", "multistructural materials" and "artificially structured materials"; Manufacturing: "advanced manufacturing" and "advanced processing".
In our study, the starting point is the above-mentioned terms, which have been further refined and adapted, e.g.we have used keywords related to the 'functionality' and 'structure', applying them in the same search string.This approach has led to extraction of data (publications, projects and patents) that contain all possible combinations of the two characteristics (function and structure) of the advanced (nano) materials.
Often, advanced materials are at the nanoscale or have one or more nanoscale entities as components of their structure, for example 'nanohybrids'. 18,55In the case of nanostructured advanced materials, the assembly method is also reported 56 to play a role in determining their unique properties.In particular, smart nanomaterials both present more complex structures than conventional nanomaterials and are designed to have higher dynamism by actively transforming in response to external stimuli.
The Smart Nanomaterials Industry Analysis by BIS Research 57 forecasts the market to grow at a significant Compound Annual Growth Rate (CAGR) of 33% on the basis of value during the forecast period from 2019 to 2029.According to this study, North America dominated the global smart nanomaterials market with a share of 37% in 2019 and the key players were identified to be, in alphabetical order, Abbott, ANP Co. Ltd., Akzo Nobel N.V., Bayer AG, BASF SE, Clariant, Donaldson Company Inc., JM Material Technology Inc., Nanologica, Nanogate, NanoBeauty, OPTINANO-PRO, The Nano Gard L.L.C., and Yosemite Technologies Co. Ltd.

Possible impacts on society and policy implications
The EU policies related to the Green Deal 6 (Figure 19), bring various opportunities to stakeholders (e.g.researchers, industry), but at the same time the policies come with major challenges regarding their implementation, e.g.upcoming updates (or new) of legislation, funding within the Horizon Europe Framework Programme (2021-2027) and beyond, and, in general, the alignment between legislation, industry and consumers.All these players will be influenced in one way or another by the implementation of the European Green Deal policy and its related actions (e.g.chemicals sustainability strategy, farm to fork, the industrial strategy and the circular economy action plan).The Chemicals Strategy for Sustainability Towards a Toxic-Free Environment is presented in an EC Communication 4 that in its Annex proposes more than 80 key actions related to the implementation of the Chemicals Strategy for Sustainability.The actions are grouped in five main categories: i) innovating for safe and sustainable EU chemicals, ii) Stronger EU legal framework to address pressing environmental and health concerns, iii) Simplification and consolidation of the legal framework, iv) Providing a comprehensive and transparent knowledge base on chemicals and v) Provide a model inspiring chemicals management globally.In the coming years the actions will dominate the work on the EU chemicals policy, with a strong emphasis on updating the legislation towards a "stronger EU legal framework".
According to the EC Communication, "the measures presented in this action plan, including legislative proposals and targeted amendments to REACH, will all need to be carried out in line with the better regulation principles and subject to evaluations and impact assessments as appropriate".One of these actions refer directly to nanomaterials (i.e."Review of the definition of nanomaterial" which resulted in the adoption of the new definition 58 ), while the majority refer to chemicals in general and their safety and sustainability.

Conclusions
The study established and tested the methodology for creating a set of research and innovation indicators in the area of advanced materials, with a focus on advanced nanomaterials and smart nanomaterials (Figure 20): The methodology used a set of predefined keywords for data search and used several tools and databases for data extraction.The keywords are an essential element in establishing the indicators, as any modification will influence the input data used for the indicator.However, the authors consider that the set of keywords used in this study are representative and the results offer a good view on the analysed area.The methodology is reproducible provided the availability of access to the data extraction and databases mentioned in the study.The authors also recognise that reviews and books often compile existing research rather than presenting novel findings, which could potentially result in the duplication of information.Furthermore, the mere inclusion of a keyword in a project or conference presentation may not indicate innovation; it should be considered in the context of project outcomes.
The study developed a first set of indicators, in order to understand the level of complexity and data needed for such exercise and also to be used as a starting point for developing additional indicators or sub-indicators.
Regarding the results, there is clearly an important growth both in scientific publications, patents and EU funding.Asia, led by China, is a very important player within the area of advanced materials (e.g. publishing and patents).
Several EU initiatives 59-64 are actively promoting ontology development, as well as the standardisation of documentation of data for advanced materials, including nanomaterials.The outcomes of such projects should further support the development of the classification of advanced materials as well as the progress of data interoperability and knowledge sharing.A clearer classification and description of advanced materials will also help building and refining indicators and similar tools for monitoring the development and impact in this area.
Indicators for identification and monitoring AdMa could feed into other initiatives, such as the Early4AdMa system 65 and can generally contribute to implementing a 'Safer and Sustainable Innovation Approach' (SSIA), currently developed by the OECD and being extended to integrate the safe and sustainable by design concept, 66 or support the risk screening for such materials, e.g. 67Monitoring the area of AdMa couldwith appropriate indicators to be developedalso provide timely insights into whether, how fast and how efficiently policy ambitions and action plans are turned into reality.
As a next step, the indicators can be further extended and developed (additional or more specific sub-indicators, identify new technologies or materials), while a dashboard that integrates all the indicators could be designed.I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however It is still needs some minor editing: 1-The writings in the given tables must be in same font and as well as some figures needs to be increased in resolution.2-The author must provide SWOT analysis for this research topic and how nanomaterials will have different effects when applied in various fields.
3-Key challenges and limitations must be well discussed and clarified in the conclusion section, otherwise in a separate topic.

Priscila Falagan Lotsch
Department of Biological Sciences, College of Sciences and Mathematics, Auburn University, Auburn, Alabama, USA The manuscript aims to pinpoint areas of scientific research and technological development of advanced materials, specifically focusing on advanced nanomaterials and smart nanomaterials.
The study adopted an iterative approach, beginning with identifying and collecting data to establish relevant research and innovation indicators.Data were collected from reputable databases such as SCOPUS, CORDIS, and PATSTAT, using predefined search strings tailored to capture relevant information on advanced nanomaterials.The analysis encompassed trends, distributions, and other pertinent aspects, including geographical distribution, organizational involvement, research areas, and funding programs.The manuscript is well-written and clear and provides valuable insights into trends, impacts, and implications of advanced nanomaterials.The study contributes to a better understanding of the future landscape of advanced materials, and the findings presented serve as a foundation for further evaluations of potential societal impacts and policy implications, ultimately guiding stakeholders toward informed decision-making and responsible innovation in the field of advanced nanomaterials.

Is the work clearly and accurately presented and does it cite the current literature?
Yes

Ander Reizabal
Basque Center for Materials, Applications and Nanostructures, University of Oregon, Eugene, Oregon, USA This study undertakes the pivotal task of discerning the landscape of scientific research and technological advancements within the realm of advanced materials, with a specific emphasis on advanced nanomaterials, particularly the sub-category of smart nanomaterials.Its primary objective revolves around the systematic collection and meticulous analysis of data to construct relevant research and innovation indicators, thereby providing profound insights into prevailing trends, impacts, and other significant facets within this dynamically evolving field.To ensure clarity and transparency, this paper expounds upon the methodologies employed, encompassing an iterative process that involves documentation, the establishment of core research and innovation indicators, and the utilization of prominent databases, including SCOPUS, CORDIS, and PATSTAT.
However, as we embark on this scholarly journey, it is essential to address some critical aspects and potential refinements within the study's foundations and methodologies:

Methodology Foundations:
Objective Clarity: While the study's intent is to provide an objective representation of reality through data analysis, the introductory section contains repeated expressions and sentences that may not align with the desired objectivity.Enhancing the clarity of the 1.
introduction will effectively communicate the transparency and objectivity of the authors.
Definition of Advanced Materials: The definition provided for "advanced materials" is broad and subjective, leaving room for interpretation.Defining what constitutes an "advance" in materials science is vital to avoid ambiguity.

2.
Keyword Selection: The selection of keywords, as illustrated in Figure 3 and the related text, warrants meticulous consideration.Each chosen term should be critically evaluated for its relevance and significance within the context of advanced materials.The rationale behind their selection should be clearly elucidated.

3.
Relevance of Keywords: The mere presence of a keyword in a paper does not necessarily imply a substantive connection to the topic.The study should explore methods to determine the relevance and significance of each keyword in the context of the research.

4.
Sources of Innovation: It is important to acknowledge that reviews and books often compile existing research rather than presenting novel findings.This could potentially result in the duplication of research efforts.Additionally, the mere inclusion of a keyword in a project or conference presentation may not indicate innovation; it should be considered in the context of project outcomes.

Non-Methodology Points for Discussion and Inclusion:
Comprehensive Data: Figures such as 10, 13, 14, 15, 16, and 17 provide valuable insights but could benefit from a broader perspective.Incorporating data related to the overall growth in relevant fields can provide context and enhance the interpretation of specific trends.

1.
Grant Outcomes: Exploring data on the success rates and outcomes of grants related to advanced materials could be enlightening for stakeholders.Identifying which grants have led to tangible advancements or commercial products would be particularly valuable.

Discussion and Conclusions:
Maturity of Technology: The statement regarding technology maturation evolving from a research field to applied science requires a more robust foundation.The study should elaborate on the evidence supporting this assertion. 1.
Keyword Representation: The claim that the chosen set of keywords is representative and provides a comprehensive view of the analyzed area needs substantiation.Discussing the methodology's robustness and its ability to yield a comprehensive representation would enhance confidence in the study's results.

2.
In conclusion, this study marks an important step toward understanding the landscape of advanced materials, but careful consideration and refinement of its foundations, methodologies, and interpretations will enhance its relevance and credibility within the field of materials science research.

Are sufficient details of methods and analysis provided to allow replication by others? Yes
If applicable, is the statistical analysis and its interpretation appropriate?

Not applicable
Are all the source data underlying the results available to ensure full reproducibility?Yes

Are the conclusions drawn adequately supported by the results? No
Competing Interests: No competing interests were disclosed.
Reviewer Expertise: Materials science, smart materials I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.
terms, used later as keywords for extracting data.However, we fully agree that defining what is 'advanced material', is crucial for such a study and the authors tried to cover these aspects in the introduction and further in the Discussion section.Perhaps it is important to clarify also that the study did not intend to address specific components of advanced materials (that could be included in future and extended indicators).

Keyword Selection
Figure 3 was generated automatically with an online tool (Semantic Text Analyser -SeTA) that applies advanced text analysis techniques to large document collections, methodology detailed in the JRC Technical Report (Reference 38).SeTA was used as complementary tool for the selection of representative keywords, for the refinement and validation of previous background analysis.

Relevance of Keywords
The authors agree that additional methods may exist and can be applied for increasing the relevance and specificity of data extracted.The methodology was developed in an iterative manner, with the aim of identifying a set of 'representative keywords', without the intention of being complete.The authors consider that the keywords used are highly significant (considering the definitions used), while the relevance is adequate but indeed, both aspects can be further refined e.g. in case more specific sub-indicators will be developed.
Acknowledging that the reviewer's observation (The mere presence of a keyword in a paper does not necessarily imply a substantive connection to the topic.) is fully correct, we note that the study extracts statistical data, and hence will give an overall impression of where the field is going and that individual papers could be off the mark or undetected.

Sources of Innovation
For the core indicators presented, the authors preferred not to discriminate between the types of publications.We agree that additional, more specific, sub-indicators can be created using only a sub-set of data (e.g.categories of data shown in Figure 6).Such aspects were not within the scope of the current study, which intended to cover more general indicators.

Non-Methodology Points for Discussion and Inclusion: 1. Comprehensive Data
We thank the reviewer for sharing this idea.This would generate more complex, composite indicators, which could be one of the follow-ups of this study that aimed to generate a set of simple indicators using the tree main databases mentioned in the Methodology.

Grant Outcomes
We recognise the importance of this aspect and note that it could be further explored in a follow-up study, as it could not be addressed in the current study.

Discussion and Conclusions:
We thank the reviewer for this positive feedback.Discussion section has been refined.

Steffi Friedrichs
AcumenIST SPRL, Etterbeek, Belgium The paper is a well-written piece of a timely study into the keywords related to the field of advanced materials and nanomaterials (i.e.including 'smart' nanomaterials').The paper furthermore represents and excellent example of how policymaking could and should be connected to and supported by scientific evidence.
In the following points of mild 'criticism', I would like to encourage an improvement of the paper over and beyond its readily publishable nature.A bit of more generous punctuation or rephrasing could support better readability: -'The EU has e.g. the largest share of worldwide patent applications in advanced manufacturing technologies and the Internet of Things for mobility.'-this sentence worked in spoken language, but not in written form.the same is tru here: 'Regarding smart nanomaterials e.g."It is expected that future research activities in the European Union will investigate whether the current approach to safe-by-design covers the dynamic features of smart nanomaterials too and, if not, how to adapt it and provide manufacturers and regulators with the appropriate tools for its implementation."' detailed list of typos / errors: a space missing in the caption of Figure 9 ○ in the brackets of the first sentence under the header 'Advanced and smart (nano)materials': 'or the products and processes in which they are used for' (delete either 'in' or 'for'.
The figures could be improved, and their captions made clearer: Figure 1: it is not correct that 'advanced materials' necessarily lies on a direct line between 'European Green Deal' and 'tools and data', because the latter's sub-sections are directly related to each other.A triangular arrangement of the green, blue and red clusters may be more appropriate.Moreover, the caption should be more detailed (i.e.describe what the small hexagons around the big central ones are).where it comes from).Most importantly, many journals are assigned to more than one category; it needs to be stated that the statistics were correct for this.
Figures 11 and 12: the data on Projects is the most wobbly, when it comes to key-word analyses, because projects are based on their underlying proposal text, which are written for an entirely different purpose than publications and patents are written for: proposals aim to leverage funding during a stringent evaluation process and on a limited number of pages.There are a number of limitations and biases that should be taken into account when using text-mined data from projects; these include: The statistics used here capture winning proposals only.
○ the terms used in a proposal (and thus) project text are likely to mimic/copy those used in the call text (where projects are bound to call text); this was one of the finding in our text-mining analyses for the NanoFabNet Project (https://acumenist.com/mapping-the-scientific-landscapes-of-nanofabricationsustainability/)[NOTE: we were alerted to this 'bias' by finding that the keywords found in 'open call'-projects (e.g.Marie Curie) seemed to correspond more closely to those of publications, while the keywords used in 'call-text-bound'-calls seemed to be lagging behind in the use of keywords (because they keywords would first need to be included in the next multiannual framework, before they are used in successful proposals)].
○ similar to the previous bullet, the amount of funding for a specific area depends mostly on how much money had been earmarked for a specific scientific field by the EU.

○ ○
Figure 13: it does not seem appropriate to exclude the UK from the visualised result for the simple reason that UK-institutes are included in Figure 14.The same underlying selection should be applied to both figures so as to render them comparable.

○
Figure 15: there should be a note explaining the drop of patents at 2020 and 2021; this is an artefact that is to do with the handling and publication of patents through the relevant databases; since this artefact does not apply to publications or projects, it needs to be explained to keep the data comparable.
○ Specific comment/suggestion: -should 'actuator' not be one of the key-words (see table 1) Comment regarding the conclusions: Tt would be desirable to draw more possibilities/recommendations from the conclusions.The text makes a link between the KPIs that the EC wants to develop and the CSS, but how will the analysis and results presented in this paper contribute to this?
The paper says 'These indicators would lead to identification of trends of future scientific and technological achievements in the area of advanced nanomaterials, which in turn would be one information element when examining possible impacts on society and policy implications associated to these areas.' and it would be interesting to read more about 'how exactly' this can be achieved.

Is the work clearly and accurately presented and does it cite the current literature? Yes
Is the study design appropriate and is the work technically sound?
Figure 8: the categorisation used is based on the categories defined by the SCOPUS database (see Scopus Subject Areas), from where the original data was extracted.Indeed, one journal (and its publications) may be assigned to more than one category.This is now mentioned in the text under Methods (under 'Data extraction and analysis' section) as well as in the Results, in the text related to Figure 8.

○
Figures 11 and 12: we are indeed aware of the limitations of automatic data mining methods generally for such purposes and also in this particular case: Indeed, the indicator represents only funded (winning) projects, as mentioned in the text.

○
The tool used for data mining, TIM, uses the public information displayed in CORDIS and that is listed under the 'Fact Sheet' of the projects (title and abstract).The full proposal, generally, is not publicly available and cannot be searched.It would be interesting to look also in the Reporting or Results sections of the projects in order to cover not only the proposed text, but also the outcomes.For the latter, some results should appear in the publication statistics.However, such detailed analysis was not under the scope and was not performed in this study.

Specific comment/suggestion:
Thank you for the suggestions.For this study, it will not be possible to add it to the current list, as the addition of a new keyword will influence the whole set of indicators, thus necessitating a full repetition of the study.It should also be noted that one of the aims was to create a first list of keywords relevant for advanced materials, which can be refined based on the feedback received and can be used in any other context.Hence, the list of keywords can be updated in the next phases of the study.
For example, the addition of 'actuator' to the search list, would add e.g.nine new (9) publications (only for 2019), six new (6) patents to the overall data and no new projects.
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Figure 2 .
Figure 2. Schematic representation of the study objectives.The numbers 1, 2 and 3 represent the three objectives of the study.

( 1 )
Identify and analyse key research and innovation indicators;

Figure 3 .
Figure3.The network of most similar concepts for the term advanced nanomaterials (blue dot) extracted using SeTA tool (the concepts in orange are those closer to the term advanced nanomaterials, e.g. with a SeTA score equal or above 0.34, while in green are the concepts with a lower score).The size of the dots reflect the number of documents found by the tool e.g.advanced nanomaterials (blue dot) = 56 documents, biomaterials (orange dot) = 4761 documents, composites (green dot) = 17373 documents.

Figure 4 .
Figure 4. Fields and databases screened for creating the research and innovation indicators.

Figure 5 .
Figure 5. Data collection and analysis workflow.

Figure 6 .
Figure6.Amount and timeline for overall data for EU projects (number of projects and the year that the project started), patents and publications (articles, reviews, book chapters and conference proceedings) extracted using TIM on advanced nanomaterials (top) and smart nanomaterials (bottom).Please note that the scale of the y-axis, number of items, is different for advanced nanomaterials and smart nanomaterials.

Figure 7 .
Figure 7. Yearly distribution of publications on advanced nanomaterials and smart nanomaterials in the period 2012-2021.The pie chart shows the percentage of different types of publications on advanced nanomaterials.

Figure 8 .
Figure 8. Distribution of publications on advanced nanomaterials to different categories of journals in the period 2012 to 2021.

Figure 9 .
Figure 9.Most frequent author keywords used in the 'smart nanomaterials' publications.The box size reflects the frequency of use of the keywords.

Figure 10 .
Figure 10.Geographical distribution of publications on advanced nanomaterials (top 24 countries and the EU).The map shows the distribution of publications on advanced nanomaterials in EU countries in the period 2012-2021.

Figure 11 .
Figure 11.Yearly distribution (the bars) and percentage (the pie chart) of EU projects funded under FP5, FP6, FP7 and Horizon 2020 on advanced nanomaterials and smart nanomaterials.

Figure 12 .
Figure12.Value of EU projects (total value incl.partner contributions = € 1.18 billion) on advanced nanomaterials.To be noted that the duration of the framework programmes go from five years to seven years between FP6 and FP7.

Figure 13 .
Figure 13.Participation by EU member states in EU funded projects (FP5 to Horizon 2020) on advanced nanomaterials and smart nanomaterials; Malta does not appear as they do not participate to any project in the areas analysed; the UK left the EU on 31 January 2020 and is not included here.

Figure 14 .
Figure 14.Top 25 organisations participating in EU projects related to advanced nanomaterials; as seen Switzerland is associated to the EU research programme, and the UK was deeply involved before Brexit, with 6 institutions among the top-25 institutions at EU level.

Figure 15 .
Figure 15.Yearly distribution of patents granted on advanced nanomaterials, including smart nanomaterials (orange).

Figure 16 .
Figure 16.The ten most frequently assigned technology sub-areas for the patents on 'advanced nanomaterials' and number of patents granted for each of the sub-area represented.

Figure 17 .
Figure 17.Global geographical distribution of patents on advanced nanomaterials (top 25 countries).The map shows the distribution of patent applications for advanced nanomaterials in EU countries.

Figure 18 .
Figure 18.Indicators for publications, projects and patents.

Figure 19 .
Figure 19.Communication of several actions related to the European Green Deal.

Figure 20 .
Figure 20.Summary results for the three fields analysed (1996-2021).The numbers represent the total items analysed for advanced nanomaterials, while the total number of items analysed for smart nanomaterials are given in the brackets.

○Figure 2 :Figure 8 :
Figure 2: the caption needs to be more detailed: what do the numbers (1) -(2) -(3) describe.The figure should take more care to making sure that the elements of a list are of comparable nature (i.e.'consumers' and 'environment' in a list of 'policy', 'legislation', 'funding') ○

○○Figure 13 :○Figure 15 :
Figure13: this figure is based on TIM's automatic filter for EU countries and aimed to reflect the situation at the moment when the data was extracted (2022), for EU.In addition, the analysis looked in more detail, in order to show also the contribution of former EU countries (such as UK) or associated countries in the Horizon FPs (such as Switzerland), etc., through their organisations involved in the projects.A more general indicator (including all European countries or worldwide, not only EU) may be used to show this data.○

Table 1 .
List of final keywords describing the advanced materials including a sub-set of keywords specific to smart materials and nanomaterials.

Table 2 .
Search strings used in the searches performed in TIM.The first string is the general final string, and the subsequent entries show the extension of each string for the three cases of publications, projects and patents.

Table 3 .
List and description of indicators.

Table 4
. Distribution of patents technology areas for advanced nanomaterials, including smart nanomaterials, according to the international patent classification.*Category according to the United States Patent and Trademark Office (USPTO): Y = general tagging of new technological developments; general tagging of cross-sectional technologies spanning over several sections of the IPC.
Communication from the Commission to the European Parliament, the Council, the European Economic and Social Committee and the Committee of the Regions.The European Green Deal COM (2019) 640.2019.Safe and sustainable by design chemicals and materials: framework for the definition of safe and sustainable by design criteria for chemicals and materials.Publications Office of the European Union.2022.Publisher Full Text 46.Wu H, Shabala L, Shabala S, et al.: Hydroxyl radical scavenging by cerium oxide nanoparticles improves Arabidopsis salinity tolerance by enhancing leaf mesophyll potassium retention.Environ.Sci.Nano.2018; 5(7): 1567-1583.

the work clearly and accurately presented and does it cite the current literature? Yes Is the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Not applicable Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? Partly Competing Interests:
No competing interests were disclosed.

have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.
This is an open access peer review report distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? Not applicable Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? Yes Competing Interests:
No competing interests were disclosed.

have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Version 1
This is an open access peer review report distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.