<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN" "http://jats.nlm.nih.gov/publishing/1.2/JATS-journalpublishing1.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="systematic-review" dtd-version="1.2" xml:lang="en">
    <front>
        <journal-meta>
            <journal-id journal-id-type="pmc">F1000Research</journal-id>
            <journal-title-group>
                <journal-title>F1000Research</journal-title>
            </journal-title-group>
            <issn pub-type="epub">2046-1402</issn>
            <publisher>
                <publisher-name>F1000 Research Limited</publisher-name>
                <publisher-loc>London, UK</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="doi">10.12688/f1000research.128144.1</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Systematic Review</subject>
                </subj-group>
                <subj-group>
                    <subject>Articles</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Barriers to compliance with evidence-based guidelines for ventilator-associated pneumonia among critical care nurses: A scoping review</article-title>
                <fn-group content-type="pub-status">
                    <fn>
                        <p>[version 1; peer review: 1 approved, 1 approved with reservations]</p>
                    </fn>
                </fn-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author" corresp="yes">
                    <name>
                        <surname>Al-Tamimi</surname>
                        <given-names>Muna</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Project Administration</role>
                    <role content-type="http://credit.niso.org/">Resources</role>
                    <role content-type="http://credit.niso.org/">Software</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <uri content-type="orcid">https://orcid.org/0000-0003-2094-2153</uri>
                    <xref ref-type="corresp" rid="c1">a</xref>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Refaat</surname>
                        <given-names>Fatma</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Project Administration</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Bani Issa</surname>
                        <given-names>Wegdan</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Project Administration</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0001-8551-9052</uri>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <aff id="a1">
                    <label>1</label>Department of Nursing, College of Health Sciences, University of Sharjah, Sharjah, Sharjah, 27272, United Arab Emirates</aff>
            </contrib-group>
            <author-notes>
                <corresp id="c1">
                    <label>a</label>
                    <email xlink:href="mailto:mal-tamimi@sharjah.ac.ae">mal-tamimi@sharjah.ac.ae</email>
                </corresp>
                <fn fn-type="conflict">
                    <p>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>21</day>
                <month>12</month>
                <year>2022</year>
            </pub-date>
            <pub-date pub-type="collection">
                <year>2022</year>
            </pub-date>
            <volume>11</volume>
            <elocation-id>1551</elocation-id>
            <history>
                <date date-type="accepted">
                    <day>18</day>
                    <month>11</month>
                    <year>2022</year>
                </date>
            </history>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2022 Al-Tamimi M et al.</copyright-statement>
                <copyright-year>2022</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <self-uri content-type="pdf" xlink:href="https://f1000research.com/articles/11-1551/pdf"/>
            <abstract>
                <p>
                    <bold>Background:</bold> Healthcare organizations provide evidence-based guidelines designed to support nurses in preventing ventilator-associated pneumonia (VAP) in intensive care units (ICUs), but there are barriers to compliance with such guidelines. This review explicitly explored evidence of compliance barriers among critical care nurses.</p>
                <p>
                    <bold>Methods:</bold> A systematic search was conducted in PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and EBSCO databases for relevant English-language studies published between January 2003 and June 2022, focused on barriers to nursing compliance with VAP prevention guidelines. Data was reported according to the Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMAScR) guidelines.</p>
                <p>
                    <bold>Results:</bold> 230 publications were screened, resulting in 53 full-text articles being retrieved after removing duplicates, of which 13 relevant to the aims of the review and meeting the inclusion criteria were included for data extraction. One was a qualitative study, while the remainder were quantitative. Simple descriptive content analysis identified the barriers to critical care nurses&#x2019; compliance with VAP prevention guidelines, and categorized them as: (1) work environment barriers 
                    <italic toggle="yes">(e.g.</italic>, 
                    <italic toggle="yes">lack of equipment and supplies</italic>; 
                    <italic toggle="yes">lack of staff and time; lack of educational support</italic>; and 
                    <italic toggle="yes">ineffective supportive system</italic>); (2) nurse-related barriers (
                    <italic toggle="yes">limited personal competencies</italic>); and (3) situation-related barriers (
                    <italic toggle="yes">patient health, discomfort, and adverse events</italic>).</p>
                <p>
                    <bold>Conclusions:</bold> This review revealed important evidence on barriers to VAP prevention guidelines compliance. Nurses are challenged mainly by work-environmental barriers along, with the presence of nurse and situational barriers. It is evident from the findings that further qualitative and mixed-methodology follow-up studies are recommended to further explore the issues in depth. Healthcare leaders must be aware of these barriers and integrate work policies that assist in overcoming them, to increase compliance.</p>
            </abstract>
            <kwd-group kwd-group-type="author">
                <kwd>Barriers; Compliance</kwd>
                <kwd>Critical care nurses; Ventilator-associated pneumonia; Prevention guidelines</kwd>
            </kwd-group>
            <funding-group>
                <funding-statement>The author(s) declared that no grants were involved in supporting this work.</funding-statement>
            </funding-group>
        </article-meta>
    </front>
    <body>
        <sec id="sec1" sec-type="intro">
            <title>Introduction</title>
            <p>Ventilator-associated pneumonia (VAP) is a common and arduous respiratory infection that targets mechanically ventilated patients (MVPs) in intensive care units (ICUs) (
                <xref ref-type="bibr" rid="ref15">Hunter, 2012</xref>; 
                <xref ref-type="bibr" rid="ref26">Metersky &amp; Kalil, 2018</xref>; 
                <xref ref-type="bibr" rid="ref43">Valles 
                    <italic toggle="yes">et al.</italic>, 1995</xref>). VAP is characterized as an infection of the pulmonary parenchyma that appears after at least 48 hours of endotracheal intubation for mechanical ventilation, with day 1 being the day of ventilator insertion. It causes about a third of nosocomial pneumonia cases in ICUs (
                <xref ref-type="bibr" rid="ref40">Torres 
                    <italic toggle="yes">et al.</italic>, 2017</xref>). According to a Centers for Disease Control and Prevention (CDC) report, pneumonia was the most common infection in US acute care hospitals in 2015, with 32% occurring as a result of the use of ventilators (
                <xref ref-type="bibr" rid="ref25">Magill 
                    <italic toggle="yes">et al.</italic>, 2018</xref>). Another study conducted across three Gulf Cooperation Council countries (Bahrain, Oman, and Saudi Arabia) estimated that the local VAP rate was 217% higher than in the US, according to National Healthcare Safety Network data (
                <xref ref-type="bibr" rid="ref12">El-Saed 
                    <italic toggle="yes">et al.</italic>, 2016</xref>). Ventilated patients who develop VAP suffer higher mortality than ventilated patients who do not (
                <xref ref-type="bibr" rid="ref16">Ibrahim 
                    <italic toggle="yes">et al.</italic>, 2001</xref>; 
                <xref ref-type="bibr" rid="ref37">Safdar 
                    <italic toggle="yes">et al.</italic>, 2005</xref>). Moreover, VAP substantially increases ventilator time and length of ICU stay (
                <xref ref-type="bibr" rid="ref29">Papazian 
                    <italic toggle="yes">et al.</italic>, 2020</xref>), along with ICU care costs (
                <xref ref-type="bibr" rid="ref44">Warren 
                    <italic toggle="yes">et al.</italic>, 2003</xref>; 
                <xref ref-type="bibr" rid="ref47">Zimlichman 
                    <italic toggle="yes">et al.</italic>, 2013</xref>).</p>
            <p>As a result of the high mortality, morbidity, and hospital expenses associated with VAP, a number of guidelines have been published since the 1980s to prevent and control it (
                <xref ref-type="bibr" rid="ref34">Rello 
                    <italic toggle="yes">et al.</italic>, 2002</xref>; 
                <xref ref-type="bibr" rid="ref5">Society &amp; America, 2005</xref>). Efforts continued by health organizations and societies such as the European Centre for Disease Prevention and Control (ECDC) and the CDC to set and update evidence-based guidelines (EBGs) and strategies that markedly proved to minimize the occurrence of VAP and improve outcomes, and the quality of care (QoC) delivered to MVPs (
                <xref ref-type="bibr" rid="ref17">(IHI). 2012</xref>; 
                <xref ref-type="bibr" rid="ref24">Klompas 
                    <italic toggle="yes">et al.</italic>, 2022</xref>; 
                <xref ref-type="bibr" rid="ref40">Torres 
                    <italic toggle="yes">et al.</italic>, 2017</xref>).</p>
            <p>Nurses play a pivotal role in providing safe and direct care to MVPs, including practicing VAP prevention strategies that essential to prevent infection and therefore improve the quality of patient care and outcomes in ICUs (
                <xref ref-type="bibr" rid="ref20">Jansson 
                    <italic toggle="yes">et al.</italic>, 2013</xref>; 
                <xref ref-type="bibr" rid="ref27">Osti 
                    <italic toggle="yes">et al.</italic>, 2017</xref>)</p>
            <p>According to 
                <xref ref-type="bibr" rid="ref32">Pogorzelska 
                    <italic toggle="yes">et al.</italic> (2011)</xref>, nursing compliance with VAP prevention guidelines in ICUs (hereinafter &#x201c;NC&#x201d;) should be at least 95%, in order to effectively reduce VAP incidence. Therefore, strict compliance with strategies and recommendations is required from nurses, who must appropriately perform several interventions and procedures to achieve optimum outcomes (
                <xref ref-type="bibr" rid="ref10">Miranda da Cruz &amp; da Silva Martins, 2019</xref>; 
                <xref ref-type="bibr" rid="ref33">Rello 
                    <italic toggle="yes">et al.</italic>, 2013</xref>; 
                <xref ref-type="bibr" rid="ref38">Tabaeian 
                    <italic toggle="yes">et al.</italic>, 2017</xref>).</p>
            <p>Facilitating and promoting changes in patient care, and encouraging NC is crucial for VAP prevention success, and also providing regular feedback on process measure performance and outcome rates are among the best practices to facilitate adherence with guidelines (
                <xref ref-type="bibr" rid="ref9">Crunden 
                    <italic toggle="yes">et al.</italic>, 2005</xref>; 
                <xref ref-type="bibr" rid="ref23">Klompas, 2017</xref>).</p>
            <p>In spite of the existence of clinical practice guidelines for preventing VAP, these guidelines are not consistently followed (
                <xref ref-type="bibr" rid="ref8">Cason 
                    <italic toggle="yes">et al.</italic>, 2007</xref>; 
                <xref ref-type="bibr" rid="ref35">Ricart 
                    <italic toggle="yes">et al.</italic>, 2003</xref>). Reported levels of compliance with and proper use of strategies vary widely in various contexts, across health systems, specialties, and nurses, ranging from 20% to nearly 100% (
                <xref ref-type="bibr" rid="ref48">Beattie 
                    <italic toggle="yes">et al.</italic>, 2012</xref>; 
                <xref ref-type="bibr" rid="ref49">Bird 
                    <italic toggle="yes">et al.</italic>, 2010</xref>; 
                <xref ref-type="bibr" rid="ref34">Rello 
                    <italic toggle="yes">et al.</italic>, 2002</xref>). Several studies showed that nurses generally exhibit low NC, which could be attributable to diverse factors (
                <xref ref-type="bibr" rid="ref3">Aloush 
                    <italic toggle="yes">et al.</italic>, 2018</xref>; 
                <xref ref-type="bibr" rid="ref4">Aloush &amp; Al-Rawajfa, 2020</xref>; 
                <xref ref-type="bibr" rid="ref18">Jahansefat 
                    <italic toggle="yes">et al.</italic>, 2016</xref>; 
                <xref ref-type="bibr" rid="ref19">Jam 
                    <italic toggle="yes">et al.</italic>, 2018</xref>). Given the critical impact of NC on patients&#x2019; QoC, it is essential to identify the factors influencing it that might impede the proper implementation of EBGs, and hence affect patient outcomes.</p>
            <p>There are few existing reviews of studies reporting NC barriers (hereinafter &#x201c;NCBs&#x201d;). Consequently, it is vital to comprehensively map the evidence on relating to the findings available in this topic, how studies have been conducted, the key characteristics of studies, and important knowledge gaps. A scoping review is used to explore the breadth or extent of the literature, map and summarize the evidence, and inform future research (
                <xref ref-type="bibr" rid="ref42">Tricco 
                    <italic toggle="yes">et al.</italic>, 2016</xref>). This scoping review aimed to show the available evidence of the barriers toward critical care nurses&#x2019; (CCNs) NC. The primary objective of this scoping review is to understand the types and extent of evidence available in relation to NCBs. The detailed aims of this review were to: (1) examine the characteristics of studies that have reported the barriers toward preventing VAP guidelines among CCNs; (2) identify and summarize key findings of related studies; and (3) identify gaps of extant studies that may help inform future research in this area.</p>
        </sec>
        <sec id="sec2" sec-type="methods">
            <title>Methods</title>
            <sec id="sec3">
                <title>Design</title>
                <p>The scoping review was conducted in accordance with the Joanna Briggs Institute (JBI) methodology to determine CCNs&#x2019; NCBs for VAP EBGs. It followed the frameworks of Arksey and O'Malley (2005) and Levac 
                    <italic toggle="yes">et al.</italic> (2010) that have underpinned the development of the JBI approach for conducting scoping reviews (
                    <xref ref-type="bibr" rid="ref30">Peters 
                        <italic toggle="yes">et al.</italic>, 2015</xref>). Moreover, It is reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) to provide a guidelines to the review (
                    <xref ref-type="bibr" rid="ref41">Tricco 
                        <italic toggle="yes">et al.</italic>, 2018</xref>). Population-Concept-Context (PCC) elements is followed in line with JBI&#x2019;s recommendations for scoping reviews, in order to guide the inclusion criteria development, facilitate literature searches, and offer a robust framework of this scoping review (
                    <xref ref-type="bibr" rid="ref31">Peters 
                        <italic toggle="yes">et al.</italic>, 2020</xref>).</p>
            </sec>
            <sec id="sec4">
                <title>Review question</title>
                <p>This scoping review examined the following research question: What are the barriers to compliance with the VAP prevention guidelines among CCNs. The population comprised nurses practicing in any country. The core concept examined was the barriers to compliance with VAP guidelines prevention and the context was ICUs.</p>
            </sec>
            <sec id="sec5">
                <title>Eligibility criteria</title>
                <p>The search was performed between March-June 2022 to include relevant studies in English language only (excluding non-English language studies as they required translation), using the electronic research databases Cumulative Index to Nursing and Allied Health Literature (CINAHL), PubMed, and EBSCO. Database searches were targeted to full-text, peer-reviewed articles, including primary research and any type of review. Relevant articles selected for review were published between January 2003 and June 2022, to include studies since the issuance of the CDC&#x2019;s updated recommendation &#x201c;Guidelines for Preventing Health-Care--Associated Pneumonia&#x201d; (
                    <xref ref-type="bibr" rid="ref39">Tablan 
                        <italic toggle="yes">et al.</italic>, 2003</xref>). Data were collected using the main keywords on VAP, Prevention guidelines, Barriers, Compliance, Intensive care, and Nurses. The detailed search strategy is available as additional file in the data availability. The participants of the included studies had to be CCNs and charge nurses who had worked directly with MVPs, with responsibility for implementing the VAP prevention guidelines (hereinafter &#x201c;VAP PGs&#x201d;) for which they were reporting the perceived NCBs. Assistant nurses, nurse managers and other health professionals were excluded. The focus of studies had to be identifying barriers to NC with VAP PGs. Other factors that were irrelevant or which did not hinder NC were excluded. The included studies had to have been conducted in ICUs using mechanical ventilation for patients. 
                    <xref ref-type="table" rid="T1">Table 1</xref> summarizes the inclusion and exclusion criteria for the selected studies.</p>
                <table-wrap id="T1" orientation="portrait" position="float">
                    <label>Table 1. </label>
                    <caption>
                        <title>Inclusion and exclusion criteria for selected studies.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Inclusion criteria</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Exclusion criteria</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">English</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Non-English</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">January 2003 and June 2022</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Before or after the inclusion date</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Primary studies and reviews</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Theses, reports, editorials</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Full text, peer-reviewed studies</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Non-peer-reviewed studies, not available in full-text version, unpublished (grey) literature</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Critical care nurses, including nurses in charge, directly responsible for mechanically ventilated patients, and applying strategies and guidelines for VAP prevention</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Nurses in charge and nurse managers who do not care directly with mechanically ventilated patients.
                                    <break/>Assistant nurses, other healthcare professionals</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Barriers (obstacles) to nurses&#x2019; compliance with VAP prevention guidelines</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Other factors that irrelevant or not hindering nurses&#x2019; compliance with VAP prevention guidelines</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">ICUs caring for mechanically ventilated patients</td>
                                <td align="char" char="&#x00d7;" colspan="1" rowspan="1" valign="top">&#x2009;</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
            </sec>
            <sec id="sec6">
                <title>Study selection</title>
                <p>The search results were collated, uploaded to EndNote X9.3.3/2008 (RRID:SCR_014001; Clarivate Analytics, PA, USA), and duplicates were removed. Three reviewers (MA, FR, and WB) independently screened titles and abstracts to determine whether they met inclusion criteria. Relevant sources were retrieved in full. A hand search of the bibliographies of initially included studies was undertaken in order to identify additional relevant works not gleaned from the database search (
                    <xref ref-type="bibr" rid="ref31">Peters 
                        <italic toggle="yes">et al.</italic>, 2020</xref>). All reviewers independently examined the full texts of selected citations to ensure that they met the inclusion criteria, and evidence sources that did not meet the inclusion criteria were excluded. During the selection process, disagreements between the reviewers were resolved through discussion, as detailed in the Results section.</p>
            </sec>
            <sec id="sec7">
                <title>Data extraction</title>
                <p>Data were extracted from the articles by the reviewers using JBI data extraction tool. Detailed information about the authors, years of publications, country, study aims, study methods, and key findings relevant to the review aim/s were extracted (
                    <xref ref-type="table" rid="T2">Table 2</xref>). The data extraction tool was revised and modified by all authors as necessary during the process of extracting data from each evidence source included in this review. A discussion was used to resolve disagreements between reviewers. There was no need to contact the authors of the articles due to the comprehensiveness of reported data (
                    <italic toggle="yes">i.e.</italic>, no missing data).</p>
                <table-wrap id="T2" orientation="portrait" position="float">
                    <label>Table 2. </label>
                    <caption>
                        <title>Extraction sheet of the studies.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Author(s), year, country</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Aim/purpose</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Sample size</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Methodology</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Key relevant findings</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref4">Aloush and Al-Rawajfa (2020)</xref>
                                    <break/>Jordan</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">To evaluate the compliance of Jordanian nurses with VAP prevention guidelines and the barriers to compliance</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">294</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Quantitative cross-sectional design
                                    <break/>Descriptive survey Self-administered questionnaire</td>
                                <td colspan="1" rowspan="1" valign="top">Lack of education
                                    <break/>Lack of policies and protocols
                                    <break/>Lack of resources
                                    <break/>Shortage of staff</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref3">Aloush 
                                        <italic toggle="yes">et al.</italic> (2018)</xref>
                                    <break/>Middle East (Jordan, Egypt, Saudi Arabia)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">To investigate barriers and factors that affect nurses&#x2019; level of compliance with VAP prevention guidelines</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">471</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Quantitative cross-sectional design
                                    <break/>Self-reported survey</td>
                                <td colspan="1" rowspan="1" valign="top">Lack of education
                                    <break/>Lack of guidance
                                    <break/>Lack of a professional model
                                    <break/>Poor integration of research findings in practice
                                    <break/>Lack of experience
                                    <break/>Unavailability of resources</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref1">Al-Sayaghi (2021)</xref>
                                    <break/>Saudi Arabia</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">To determine the factors that affect nurses&#x2019; compliance and explore barriers faced by them</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">229</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Quantitative cross-sectional design
                                    <break/>Descriptive survey
                                    <break/>Self-reported questionnaire</td>
                                <td colspan="1" rowspan="1" valign="top">Shortage of nursing staff
                                    <break/>Lack of time
                                    <break/>Forgetfulness
                                    <break/>Hospital cost control policies
                                    <break/>Lack of continuous education
                                    <break/>Fear of unpredictable adverse effects and undesirable patient outcomes</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref6">Atashi 
                                        <italic toggle="yes">et al.</italic> (2018)</xref>
                                    <break/>Iran</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">To explore barriers to VAP prevention</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">23</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Qualitative descriptive study
                                    <break/>Semi-structured interviews</td>
                                <td colspan="1" rowspan="1" valign="top">Inadequate or inappropriate equipment
                                    <break/>Heavy workload
                                    <break/>Staff shortage
                                    <break/>Inadequate staff training and supervision
                                    <break/>Limited professional competence
                                    <break/>Unfavorable environmental conditions
                                    <break/>Passive human resource management
                                    <break/>Unfavorable professional attitudes
                                    <break/>Low job motivation
                                    <break/>Limited professional accountability
                                    <break/>Nonstandard physical structure</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref7">Bankanie 
                                        <italic toggle="yes">et al.</italic> (2021)</xref>
                                    <break/>Tanzania</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">To explore barriers to VAP prevention EBGs</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">116</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Quantitative cross-sectional design
                                    <break/>Descriptive survey
                                    <break/>Self-administered questionnaire</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Lack of skills
                                    <break/>Lack of staff
                                    <break/>Lack of knowledge
                                    <break/>Job discretion
                                    <break/>VAP procedures considered unnecessary</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref11">Dehghan 
                                        <italic toggle="yes">et al.</italic> (2022)</xref>
                                    <break/>Iran</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">To examine registered nurses&#x2019; perceived barriers towards VAP prevention in southeast Iran</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">321</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Quantitative cross-sectional design
                                    <break/>Descriptive survey
                                    <break/>Self-administered questionnaire</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Lack of staff
                                    <break/>Lack of a team-based approach to care and interventions
                                    <break/>Lack of support from management
                                    <break/>Concern of harming the patient
                                    <break/>Concern of detachment of attached tubes
                                    <break/>Concern of side effects</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref14">Hassan and Wahsheh (2017)</xref>
                                    <break/>Jordan</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">To identify reasons for not applying VAP prevention measures</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">428</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Quantitative cross-sectional design
                                    <break/>Descriptive survey
                                    <break/>Self-administered questionnaire</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Lack of time
                                    <break/>No followed protocols in the units
                                    <break/>Patient discomfort
                                    <break/>Disagreement with guidelines</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref20">Jansson 
                                        <italic toggle="yes">et al.</italic> (2013)</xref>
                                    <break/>Finland</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">To explore barriers towards VAP prevention EBGs</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">101</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Quantitative cross-sectional design
                                    <break/>Descriptive survey
                                    <break/>Self-reported questionnaire</td>
                                <td colspan="1" rowspan="1" valign="top">Inadequate resources
                                    <break/>Lack of time
                                    <break/>Lack of skills
                                    <break/>Lack of knowledge
                                    <break/>Lack of guidance</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref21">Jansson 
                                        <italic toggle="yes">et al.</italic> (2018)</xref>
                                    <break/>Finland</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">To evaluate barriers to institution-specific ventilator bundle</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">108</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Quantitative cross-sectional design
                                    <break/>Self-administered questionnaire</td>
                                <td colspan="1" rowspan="1" valign="top">Role ambiguities
                                    <break/>Lack of education
                                    <break/>Inadequate resources
                                    <break/>Lack of outcome expectancy
                                    <break/>Patient discomfort
                                    <break/>Fear of adverse effects
                                    <break/>Disagreement
                                    <break/>Lack of guidelines
                                    <break/>Forgetfulness</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref22">Kiyoshi-Teo 
                                        <italic toggle="yes">et al.</italic> (2014)</xref>
                                    <break/>USA</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">To identify factors influencing VAP prevention guidelines adherence</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">576</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Quantitative cross-sectional design
                                    <break/>Descriptive survey
                                    <break/>Self-administered questionnaire</td>
                                <td colspan="1" rowspan="1" valign="top">Time to actually complete the intervention</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref35">Ricart 
                                        <italic toggle="yes">et al.</italic> (2003)</xref>
                                    <break/>Spain</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">To review barriers to nursing adherence to nonpharmacological EBGs for preventing VAP</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">51</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Quantitative cross-sectional design
                                    <break/>Descriptive survey
                                    <break/>Self-administered questionnaire</td>
                                <td colspan="1" rowspan="1" valign="top">Unavailability of resources (37.0%)
                                    <break/>Patient discomfort
                                    <break/>Fear of potential adverse effects
                                    <break/>Overwork or lack of time
                                    <break/>Costs</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref45">Yaseen and Salameh (2015)</xref>
                                    <break/>Saudi Arabia</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">To estimate Saudi critical care nurses&#x2019; knowledge regarding VAP prevention guidelines and explore the barriers that may restrict adherence</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">93</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Quantitative cross-sectional design
                                    <break/>Descriptive survey</td>
                                <td colspan="1" rowspan="1" valign="top">Lack of VAP courses Nursing shortage
                                    <break/>Lack of VAP knowledge during nursing education
                                    <break/>Lack of time</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref46">Yeganeh 
                                        <italic toggle="yes">et al.</italic> (2019)</xref>
                                    <break/>Iran</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">To investigate barriers to implementing VAP prevention EBGs</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">219</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Quantitative cross-sectional design
                                    <break/>Observation
                                    <break/>Questionnaire</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Insufficient supply and equipment
                                    <break/>Insufficient educational seminars and materials</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
            </sec>
            <sec id="sec8">
                <title>Data synthesis</title>
                <p>The relevant literature was summarized in separate tables based on the review aims. For this review, a critical appraisal of individual sources of evidence was not necessary (
                    <xref ref-type="bibr" rid="ref31">Peters 
                        <italic toggle="yes">et al.</italic>, 2020</xref>). All authors independently reviewed the studies of NCBs in ICUs and extracted the barriers described in the results sections of the included studies. They were subsequently grouped into categories and subcategories, based on the identified contexts of barriers, using basic descriptive content analysis, which is an optimal method to summarize findings (
                    <xref ref-type="bibr" rid="ref13">Elo &amp; Kyng&#x00e4;s, 2008</xref>). The principles of inductive content analysis were used to analyze, categorize, and quantify NCBs for VAP prevention. After an initial open-coded base, similar open-codes were grouped together into thematic categories, each of which was labelled using content-specific keywords and subcategories.</p>
            </sec>
        </sec>
        <sec id="sec9" sec-type="results">
            <title>Results</title>
            <p>The initial search of this review identified 400 articles. A total of 230 non-duplicate records were subsequently identified through the searching of databases and the reference lists of included articles. After screening titles and abstracts (objectives of the articles) for relevancy against inclusion criteria, 53 articles were identified and retrieved for full-text data extraction and screening. Of these, 53 articles, 13 met all inclusion criteria and were included in this review. The flow chart (
                <xref ref-type="fig" rid="f1">Figure 1</xref>) of the review decision process was adapted from the PRISMA flowchart (
                <xref ref-type="bibr" rid="ref28">Page 
                    <italic toggle="yes">et al.</italic>, 2021</xref>).</p>
            <fig fig-type="figure" id="f1" orientation="portrait" position="float">
                <label>Figure 1. </label>
                <caption>
                    <title>PRISMA flow diagram.</title>
                </caption>
                <graphic id="gr1" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/140706/2044088b-44cc-40ca-8f38-73e40a062c63_figure1.gif"/>
            </fig>
            <sec id="sec10">
                <title>General characteristics of included studies</title>
                <p>Of the 13 included studies (as shown in 
                    <xref ref-type="table" rid="T3">Table 3</xref>), one was qualitative (
                    <xref ref-type="bibr" rid="ref6">Atashi 
                        <italic toggle="yes">et al.</italic>, 2018</xref>) and the remainder quantitative. The included studies were published between 2003 and 2022, with the following numbers of study per country: two (15.4%) in Finland (
                    <xref ref-type="bibr" rid="ref20 ref21">Jansson 
                        <italic toggle="yes">et al.</italic>, 2013, 2018</xref>); three (23%) in Iran (
                    <xref ref-type="bibr" rid="ref6">Atashi 
                        <italic toggle="yes">et al.</italic>, 2018</xref>; 
                    <xref ref-type="bibr" rid="ref11">Dehghan 
                        <italic toggle="yes">et al.</italic>, 2022</xref>; 
                    <xref ref-type="bibr" rid="ref46">Yeganeh 
                        <italic toggle="yes">et al.</italic>, 2019</xref>); two (15.4%) in Jordan (
                    <xref ref-type="bibr" rid="ref4">Aloush &amp; Al-Rawajfa, 2020</xref>; 
                    <xref ref-type="bibr" rid="ref14">Hassan &amp; Wahsheh, 2017</xref>); one (7.7%) in Jordan, Egypt, and Saudi Arabia (&#x201c;Middle East&#x201d;) (
                    <xref ref-type="bibr" rid="ref3">Aloush 
                        <italic toggle="yes">et al.</italic>, 2018</xref>); one (7.7%) in Spain (
                    <xref ref-type="bibr" rid="ref35">Ricart 
                        <italic toggle="yes">et al.</italic>, 2003</xref>); two (15.4%) in Saudi Arabia (
                    <xref ref-type="bibr" rid="ref1">Al-Sayaghi, 2021</xref>; 
                    <xref ref-type="bibr" rid="ref45">Yaseen &amp; Salameh, 2015</xref>); one (7.7%) in Tanzania (
                    <xref ref-type="bibr" rid="ref7">Bankanie 
                        <italic toggle="yes">et al.</italic>, 2021</xref>); and one (7.7%) in the USA (
                    <xref ref-type="bibr" rid="ref22">Kiyoshi-Teo 
                        <italic toggle="yes">et al.</italic>, 2014</xref>).</p>
                <table-wrap id="T3" orientation="portrait" position="float">
                    <label>Table 3. </label>
                    <caption>
                        <title>Summary of general characteristics of studies.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Study</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Country</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Aim/purpose</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Methodology</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref3">Aloush 
                                        <italic toggle="yes">et al.</italic> (2018)</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Middle East (Jordan, Egypt, and Saudi Arabia)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">To investigate the barriers and factors that affect nurses&#x2019; level of compliance with VAP prevention guidelines</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Quantitative self-reported survey, cross-sectional design</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref4">Aloush &amp; Al-Rawajfa (2020)</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Jordan</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">To evaluate the compliance of Jordanian nurses with VAP prevention guidelines and barriers to compliance</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Quantitative descriptive survey, self-administered questionnaire, cross-sectional design</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref1">Al-Sayaghi (2021)</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Saudi Arabia</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">To identified critical care nurses&#x2019; compliance and barriers toward ventilator-associated pneumonia prevention guidelines</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Quantitative descriptive survey self-reported questionnaire, cross-sectional design</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref3">Atashi 
                                        <italic toggle="yes">et al.</italic> (2018)</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Iran</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">To explore the perspectives of Iranian critical care nurses on the barriers to VAP prevention in ICUs</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Qualitative descriptive design, semi-structured interviews</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref7">Bankanie 
                                        <italic toggle="yes">et al.</italic> (2021)</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Tanzania</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">To explore ICU nurses&#x2019; knowledge, compliance, and barriers towards VAP prevention EBGs in Tanzania</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Quantitative descriptive survey, self-administered questionnaire, cross-sectional design</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref11">Dehghan 
                                        <italic toggle="yes">et al.</italic> (2022)</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Iran</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">To examine registered nurses&#x2019; perceived barriers towards VAP prevention in southeast Iran</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Quantitative descriptive survey, self-administered questionnaire, cross-sectional design</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref14">Hassan &amp; Wahsheh (2017)</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Jordan</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">To identify the level of nurses&#x2019; knowledge of VAP and prevention measures before and after an educational program in Jordan</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Quantitative descriptive survey, self-administered questionnaire, cross-sectional design</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref20">Jansson 
                                        <italic toggle="yes">et al.</italic> (2013)</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Finland</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">To explore critical care nurses&#x2019; knowledge of adherence to and barriers towards VAP prevention EBGs</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Quantitative descriptive survey, self-reported questionnaire, cross-sectional design</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref21">Jansson 
                                        <italic toggle="yes">et al.</italic> (2018)</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Finland</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">To evaluate critical care nurses&#x2019; knowledge of, adherence to, and barriers toward institution-specific ventilator bundle</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Cross-sectional design, self-administered questionnaires</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref22">Kiyoshi-Teo 
                                        <italic toggle="yes">et al.</italic> (2014)</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">USA</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Identify factors that influence adherence to guidelines for prevention of VAP</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Quantitative descriptive survey, self-administered questionnaire</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref35">Ricart 
                                        <italic toggle="yes">et al.</italic> (2003)</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Spain</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Review barriers to nursing adherence to non-pharmacological EBGs for preventing VAP.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Quantitative descriptive questionnaire</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref45">Yaseen &amp; Salameh (2015)</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Saudi Arabia</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Estimate Saudi critical care nurses&#x2019; knowledge regarding VAP (VAP) prevention guidelines and to explore the barriers that may restrict adherence to these guidelines</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Quantitative descriptive cross-sectional design survey</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref46">Yeganeh 
                                        <italic toggle="yes">et al.</italic> (2019, 2015)</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Iran</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">To investigate the barriers to implementing EBGs for VAP prevention</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Quantitative observation, questionnaire, cross-sectional design</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
            </sec>
            <sec id="sec11">
                <title>Findings of the included studies</title>
                <p>This review yielded evidence for variety of NCBs, categorized into barriers relating to the &#x201c;work-environment&#x201d;, &#x201c;nurse&#x201d;, and &#x201c;situation&#x201d;. These barriers were further categorized into subcategories of barriers: work environment (
                    <italic toggle="yes">lack of equipment and supplies</italic>; 
                    <italic toggle="yes">lack of staff and time</italic>; 
                    <italic toggle="yes">lack of educational support</italic>; and 
                    <italic toggle="yes">ineffective supportive system</italic>), nurse (
                    <italic toggle="yes">limited personal competencies</italic>), and situation (
                    <italic toggle="yes">patient health, discomfort, and adverse events</italic>) (
                    <xref ref-type="table" rid="T4">Table 4</xref>).</p>
                <table-wrap id="T4" orientation="portrait" position="float">
                    <label>Table 4. </label>
                    <caption>
                        <title>Summary of key barriers identified (categories and subcategories).</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Subcategories</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Authors</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="center" colspan="2" rowspan="1" valign="top">
                                    <bold>Work environment barriers</bold>
                                </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Lack of equipment and supplies</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref6">Atashi 
                                        <italic toggle="yes">et al.</italic> (2018)</xref>, 
                                    <xref ref-type="bibr" rid="ref4">Aloush and Al-Rawajfa (2020)</xref>, 
                                    <xref ref-type="bibr" rid="ref20">Jansson 
                                        <italic toggle="yes">et al.</italic> (2013)</xref>, 
                                    <xref ref-type="bibr" rid="ref46">Yeganeh 
                                        <italic toggle="yes">et al.</italic> (2019)</xref>
                                </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Lack of staff </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref6">Atashi 
                                        <italic toggle="yes">et al.</italic> (2018)</xref>, 
                                    <xref ref-type="bibr" rid="ref1">Al-Sayaghi (2021)</xref>, 
                                    <xref ref-type="bibr" rid="ref4">Aloush and Al-Rawajfa (2020)</xref>, 
                                    <xref ref-type="bibr" rid="ref7">Bankanie 
                                        <italic toggle="yes">et al.</italic> (2021)</xref>, 
                                    <xref ref-type="bibr" rid="ref45">Yaseen and Salameh (2015)</xref>, 
                                    <xref ref-type="bibr" rid="ref11">Dehghan 
                                        <italic toggle="yes">et al.</italic> (2022)</xref> 
                                    <xref ref-type="bibr" rid="ref20">Jansson 
                                        <italic toggle="yes">et al.</italic> (2013)</xref> 
                                    <xref ref-type="bibr" rid="ref35">Ricart 
                                        <italic toggle="yes">et al.</italic> (2003)</xref>
                                </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Lack of time</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref1">Al-Sayaghi (2021)</xref>, 
                                    <xref ref-type="bibr" rid="ref14">Hassan and Wahsheh (2017)</xref>. 
                                    <xref ref-type="bibr" rid="ref20">Jansson 
                                        <italic toggle="yes">et al.</italic> (2013)</xref>, 
                                    <xref ref-type="bibr" rid="ref22">Kiyoshi-Teo 
                                        <italic toggle="yes">et al.</italic> (2014)</xref>, 
                                    <xref ref-type="bibr" rid="ref6">Atashi 
                                        <italic toggle="yes">et al.</italic> (2018)</xref>, 
                                    <xref ref-type="bibr" rid="ref45">Yaseen and Salameh (2015)</xref>, 
                                    <xref ref-type="bibr" rid="ref35">Ricart 
                                        <italic toggle="yes">et al.</italic> (2003)</xref>
                                </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Lack of educational support</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref3">Aloush 
                                        <italic toggle="yes">et al.</italic> (2018)</xref>, 
                                    <xref ref-type="bibr" rid="ref4">Aloush and Al-Rawajfa (2020)</xref>, 
                                    <xref ref-type="bibr" rid="ref1">Al-Sayaghi (2021)</xref>, 
                                    <xref ref-type="bibr" rid="ref6">Atashi 
                                        <italic toggle="yes">et al.</italic> (2018)</xref>, 
                                    <xref ref-type="bibr" rid="ref7">Bankanie 
                                        <italic toggle="yes">et al.</italic> (2021)</xref>, 
                                    <xref ref-type="bibr" rid="ref14">Hassan and Wahsheh (2017)</xref>, 
                                    <xref ref-type="bibr" rid="ref20">Jansson 
                                        <italic toggle="yes">et al.</italic> (2013)</xref>, 
                                    <xref ref-type="bibr" rid="ref21">Jansson 
                                        <italic toggle="yes">et al.</italic> (2018)</xref>, 
                                    <xref ref-type="bibr" rid="ref45">Yaseen and Salameh (2015)</xref>, 
                                    <xref ref-type="bibr" rid="ref46">Yeganeh 
                                        <italic toggle="yes">et al.</italic> (2019)</xref>
                                </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Ineffective supportive system</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref3">Aloush 
                                        <italic toggle="yes">et al.</italic> (2018)</xref>, 
                                    <xref ref-type="bibr" rid="ref6">Atashi 
                                        <italic toggle="yes">et al.</italic> (2018)</xref>, 
                                    <xref ref-type="bibr" rid="ref7">Bankanie 
                                        <italic toggle="yes">et al.</italic> (2021)</xref>, 
                                    <xref ref-type="bibr" rid="ref11">Dehghan 
                                        <italic toggle="yes">et al.</italic> (2022)</xref>, 
                                    <xref ref-type="bibr" rid="ref21">Jansson 
                                        <italic toggle="yes">et al.</italic> (2018)</xref>
                                </td>
                            </tr>
                            <tr>
                                <td align="center" colspan="2" rowspan="1" valign="top">
                                    <bold>Nurse barriers</bold>
                                </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Limited personal competencies</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref3">Aloush 
                                        <italic toggle="yes">et al.</italic> (2018)</xref>, 
                                    <xref ref-type="bibr" rid="ref4">Aloush and Al-Rawajfa (2020)</xref>, 
                                    <xref ref-type="bibr" rid="ref7">Bankanie 
                                        <italic toggle="yes">et al.</italic> (2021)</xref>, 
                                    <xref ref-type="bibr" rid="ref20">Jansson 
                                        <italic toggle="yes">et al.</italic> (2013)</xref>, 
                                    <xref ref-type="bibr" rid="ref21">Jansson 
                                        <italic toggle="yes">et al.</italic> (2018)</xref>, 
                                    <xref ref-type="bibr" rid="ref45">Yaseen and Salameh (2015)</xref>
                                </td>
                            </tr>
                            <tr>
                                <td align="center" colspan="2" rowspan="1" valign="top">
                                    <bold>Situational barriers</bold>
                                </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Patient health, discomfort, and adverse events</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <xref ref-type="bibr" rid="ref1">Al-Sayaghi (2021)</xref>, 
                                    <xref ref-type="bibr" rid="ref11">Dehghan 
                                        <italic toggle="yes">et al.</italic> (2022)</xref>, 
                                    <xref ref-type="bibr" rid="ref14">Hassan and Wahsheh (2017)</xref>, 
                                    <xref ref-type="bibr" rid="ref21">Jansson 
                                        <italic toggle="yes">et al.</italic> (2018)</xref>, 
                                    <xref ref-type="bibr" rid="ref35">Ricart 
                                        <italic toggle="yes">et al.</italic> (2003)</xref>
                                </td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
            </sec>
        </sec>
        <sec id="sec12" sec-type="discussion">
            <title>Discussion</title>
            <sec id="sec13">
                <title>Overview</title>
                <p>This review aimed to examine the characteristics and conclusions of studies to identify barriers confronting nurses, thwarting their compliance with EBGs for VAP prevention in ICUs. It is apparent that there has been an increased rate of publication of studies assessing NCBs over the past five years (during which nine out of the 13 identified studies since 2003 were published), which reflects the increasing significance attached to this issue in nursing clinical practice and research. It underscores the need to work resolutely in reducing VAP and improving QoC for MVPs in critical care settings, particularly in Middle Eastern countries, where six of the studies were conducted. Regarding the geographical distribution of the studies, one study each (7.7%) was conducted in North America and Africa, three (23%) in Europe, and eight (61.5%) in Asia. Evidently there have been few published studies aiming to explore barriers influencing nurses&#x2019; success of VAP prevention strategies implementation at Intensive care units.</p>
                <p>Furthermore, the revised articles indicate a large degree of methodological homogeneity, with minimal variety in methodological approaches to explore barriers. The majority of the authors in the reviewed studies used quantitative approaches using self-reported questionnaires as the main data collection tool, with the exception of the study by 
                    <xref ref-type="bibr" rid="ref46">Yeganeh 
                        <italic toggle="yes">et al.</italic> (2019)</xref>, which used quantitative observational method to determine barriers; and that of 
                    <xref ref-type="bibr" rid="ref6">Atashi 
                        <italic toggle="yes">et al.</italic> (2018)</xref>, which used qualitative descriptive study with semi-structured interviews to allow a more in-depth understanding detecting real barriers experienced by nurses in ICUs.</p>
                <p>Nurses in ICUs experienced various barriers that hinder their ability to implement the recommended VAP measures in a constant and consistent manner (
                    <xref ref-type="bibr" rid="ref6">Atashi 
                        <italic toggle="yes">et al.</italic>, 2018</xref>). From the results of this scoping review, it is apparent that there are many complex, diverse and interconnected barriers that can prevent CCNs from being committed to and compliant with VAP PGs, which accordingly undermines QoC and exposes patients to VAP risk.</p>
            </sec>
            <sec id="sec14">
                <title>Work environment-related barriers</title>
                <p>This review showed many barriers within work-environment context playing the paramount role in negatively affecting NC, diverting nurses from being compliant with VAP PGs</p>
            </sec>
            <sec id="sec15">
                <title>Lack of equipment and supplies</title>
                <p>While medical supplies and equipment in ICU are vital interventional tools for VAP prevention, nurses widely reported a lack of endotracheal tubes with suctioning system and kinetic beds (
                    <xref ref-type="bibr" rid="ref3">Aloush et al., 2018</xref>; 
                    <xref ref-type="bibr" rid="ref4">Aloush &amp; Al-Rawajfa, 2020</xref>; 
                    <xref ref-type="bibr" rid="ref20">Jansson 
                        <italic toggle="yes">et al.</italic>, 2013</xref>; 
                    <xref ref-type="bibr" rid="ref46">Yeganeh 
                        <italic toggle="yes">et al.</italic>, 2019</xref>), as well as deficiencies of personal protective equipment like gloves and face masks (
                    <xref ref-type="bibr" rid="ref4">Aloush &amp; Al-Rawajfa, 2020</xref>), which prevented them from applying appropriate VAP prevention. 
                    <xref ref-type="bibr" rid="ref46">Yeganeh 
                        <italic toggle="yes">et al.</italic> (2019)</xref> observed the unavailability of most essential resources for VAP prevention (including endotracheal tubes with subglottic suctioning, closed suction systems, kinetic beds, etc.), comprising an insurmountable everyday obstacle to nurses that consistently and systematically prevented them from performing important VAP prevention strategies.</p>
                <p>According to the nurses in 
                    <xref ref-type="bibr" rid="ref6">Atashi 
                        <italic toggle="yes">et al.</italic> (2018)</xref> study, the QoC they delivered to prevent VAP was undermined because they lacked most prerequisite equipment stipulated and necessary in standard guidelines. Moreover, they were unable to prevent VAP because the physical structure of ICU did not include the required materials or permit required activities. For instance, the study reported that there was just one corridor available for the transport of both contaminated and clean materials, suctioning bottles were emptied into toilets, and there were minimal sinks available in the unit for hand washing. The nurses have no control over this problem, because the lack of required resources was due to cost control within the hospital management system. 
                    <xref ref-type="bibr" rid="ref6">Atashi 
                        <italic toggle="yes">et al.</italic> (2018)</xref> concluded that medical supplies and equipment are essential to provide safe and high-QoC for patients, and hospitals&#x2019; cost control policies can negatively influence implementation of guidelines essential for VAP prevention, counter-productively increasing the cost of care over the long term (
                    <xref ref-type="bibr" rid="ref1">Al-Sayaghi, 2021</xref>).</p>
            </sec>
            <sec id="sec16">
                <title>Lack of staff and time</title>
                <p>In ICU environments, nursing staffing is essential for providing continuous clinical services and improving the QoC of critically ill patients. Staff shortages result in overwork, burnout, and stress among working nurses, reducing nurses&#x2019; precision at work and causing the de-prioritization of VAP preventive measures amid a general reduction of QoC (
                    <xref ref-type="bibr" rid="ref6">Atashi 
                        <italic toggle="yes">et al.</italic>, 2018</xref>). There was widespread consensus in the reviewed studies that a lack of staff, which can also be conceptualized as a low nurse-to-patient ratio or high demand, is a common NCB in ICUs at different levels (
                    <xref ref-type="bibr" rid="ref1">Al-Sayaghi, 2021</xref>; 
                    <xref ref-type="bibr" rid="ref4">Aloush &amp; Al-Rawajfa, 2020</xref>; 
                    <xref ref-type="bibr" rid="ref6">Atashi 
                        <italic toggle="yes">et al.</italic>, 2018</xref>; 
                    <xref ref-type="bibr" rid="ref7">Bankanie 
                        <italic toggle="yes">et al.</italic>, 2021</xref>; 
                    <xref ref-type="bibr" rid="ref11">Dehghan 
                        <italic toggle="yes">et al.</italic>, 2022</xref>; 
                    <xref ref-type="bibr" rid="ref45">Yaseen &amp; Salameh, 2015</xref>).</p>
                <p>The most common barrier to implementing VAP prevention strategies reported by nurses in the studies by 
                    <xref ref-type="bibr" rid="ref1">Al-Sayaghi (2021)</xref> and 
                    <xref ref-type="bibr" rid="ref11">Dehghan 
                        <italic toggle="yes">et al.</italic> (2022)</xref> were the shortage of nursing staff, and these authors argued that inappropriate staff planning is a systemic issue that need to be addressed. Diminution of staff number in the ICU because of cost control policies minimizes the time available for nurses to provide appropriate VAP prevention procedures (to say nothing of holistic and non-biomedical care services, which are utterly disregarded in most busy and under-resourced ICUs). Similarly, 
                    <xref ref-type="bibr" rid="ref7">Bankanie 
                        <italic toggle="yes">et al.</italic> (2021)</xref> concluded that almost all nurses experienced difficulty in adhering with appropriate VAP prevention strategies, despite their knowledge of such guidelines. This indicates that nurses feel overstretched doing many tasks simultaneously, struggling to deliver effective care to patients while juggling numerous patient- and system-related priorities.</p>
                <p>The application of cost control policies results in a reduction of the number of nurses in ICUs, resulting in a reduction in procedure times (
                    <xref ref-type="bibr" rid="ref1">Al-Sayaghi, 2021</xref>). When nurses work in units with lower bed capacities and lower workloads, they are more likely to comply with policies and guidelines, provide better patient care, and minimize infections (
                    <xref ref-type="bibr" rid="ref1">Al-Sayaghi, 2021</xref>; 
                    <xref ref-type="bibr" rid="ref3">Aloush 
                        <italic toggle="yes">et al.</italic>, 2018</xref>; 
                    <xref ref-type="bibr" rid="ref4">Aloush &amp; Al-Rawajfa, 2020</xref>; 
                    <xref ref-type="bibr" rid="ref11">Dehghan 
                        <italic toggle="yes">et al.</italic>, 2022</xref>). This is because appropriate staffing numbers facilitate more time available for the nurses to provide the care required. Time constraints reduce QoC in clinical practice in numerous ways, which in ICUs mainly relate to the absolute prioritization of immediate biomedical needs, and a commensurate de-prioritization of long-term patient needs such as infection prevention and holistic dimensions of care. Many studies indicated that the limited time that nurses have to perform procedures related to VAP prevention is a significant factor in low NC with procedures needed for VAP prevention (
                    <xref ref-type="bibr" rid="ref1">Al-Sayaghi, 2021</xref>; 
                    <xref ref-type="bibr" rid="ref14">Hassan &amp; Wahsheh, 2017</xref>; 
                    <xref ref-type="bibr" rid="ref20">Jansson 
                        <italic toggle="yes">et al.</italic>, 2013</xref>; 
                    <xref ref-type="bibr" rid="ref22">Kiyoshi-Teo 
                        <italic toggle="yes">et al.</italic>, 2014</xref>; 
                    <xref ref-type="bibr" rid="ref35">Ricart 
                        <italic toggle="yes">et al.</italic>, 2003</xref>; 
                    <xref ref-type="bibr" rid="ref45">Yaseen &amp; Salameh, 2015</xref>).</p>
                <p>Understaffing in ICUs engenders the lack of time that nurses face, and which contributes to their low NC (
                    <xref ref-type="bibr" rid="ref1">Al-Sayaghi, 2021</xref>; 
                    <xref ref-type="bibr" rid="ref45">Yaseen &amp; Salameh, 2015</xref>). As a result of cost control policies, the number of nurses in the ICU decreases, making it difficult for procedures to be performed. Guidelines are more likely to be followed by nurses working in units with a lower workload. In an ICU with more nurses, NC would likely be better, and QoC would likely be improved (
                    <xref ref-type="bibr" rid="ref1">Al-Sayaghi, 2021</xref>). While there was consensus that a lack of time affected the delivery appropriate guidelines for VAP prevention, the reasons to which this barrier were attributed differed among studies. Although common, it was not considered to be one of the main barriers to restrict adherence with guidelines in the study by 
                    <xref ref-type="bibr" rid="ref45">Yaseen and Salameh (2015)</xref>. 
                    <xref ref-type="bibr" rid="ref21">Jansson 
                        <italic toggle="yes">et al.</italic> (2018)</xref> noted the very low significance of lack of time on low NC, and reported no effect of staffing levels on NC. Furthermore, a lack of time is not necessarily because of staff shortages. The nature of interventions in ICU also play an important role in maintaining a constant ambience of high-pressure demand and critical workload, which can contribute to the de-prioritization of non-immediate care needs.</p>
                <p>However, other studies strongly emphasized the role of a lack of time in itself. 
                    <xref ref-type="bibr" rid="ref22">Kiyoshi-Teo 
                        <italic toggle="yes">et al.</italic> (2014)</xref> considered that the time to actually complete the intervention is the only crucial environmental context of NC. Most nurses struggled to finish certain procedures compared to others, and they believed that time availability is positively associated with NC, specifically concerning oral hygiene guidelines. Therefore, time is a limiting factor for NC to complete certain interventions. Similarly, 
                    <xref ref-type="bibr" rid="ref35">Ricart 
                        <italic toggle="yes">et al.</italic> (2003)</xref> reported that some nurses felt overloaded and had no time to perform &#x201c;hand-washing between patient contacts&#x201d;; and 
                    <xref ref-type="bibr" rid="ref6">Atashi 
                        <italic toggle="yes">et al.</italic> (2018)</xref> found that some nurses felt overloaded most of the time, with patient situations necessitating a need for frequent suctioning, rendering it difficult for them to frequently wear gloves for each suctioning, which was flagged as another barrier to effective VAP prevention in ICUs.</p>
                <p>Moreover, most nurses in 
                    <xref ref-type="bibr" rid="ref14">Hassan and Wahsheh (2017)</xref> study were overwhelmed with routine ICU procedures due to lack of time, which hindered the proper application of important VAP guideline procedures. While some studies tackle both lack of adequate staffing and lengthy time needed to complete certain procedures, it was not always clear if other reasons were instrumental to the theme of a lack of time. Factors such as &#x201c;non-nurse tasks&#x201d; and &#x201c;the use of electronic documentation&#x201d; might be predisposing barriers that contribute to losing time of nurses from performing appropriate VAP prevention performance in ICUs.</p>
            </sec>
            <sec id="sec17">
                <title>Lack of educational resources</title>
                <p>In the included studies of this review, lack of education and training for VAP PGs at hospital settings was brought up many times as NCB in ICUs (
                    <xref ref-type="bibr" rid="ref1">Al-Sayaghi, 2021</xref>; 
                    <xref ref-type="bibr" rid="ref3">Aloush 
                        <italic toggle="yes">et al.</italic>, 2018</xref>; 
                    <xref ref-type="bibr" rid="ref4">Aloush &amp; Al-Rawajfa, 2020</xref>; 
                    <xref ref-type="bibr" rid="ref6">Atashi 
                        <italic toggle="yes">et al.</italic>, 2018</xref>; 
                    <xref ref-type="bibr" rid="ref21">Jansson 
                        <italic toggle="yes">et al.</italic>, 2018</xref>; 
                    <xref ref-type="bibr" rid="ref45">Yaseen &amp; Salameh, 2015</xref>; 
                    <xref ref-type="bibr" rid="ref46">Yeganeh 
                        <italic toggle="yes">et al.</italic>, 2019</xref>). In-service staff education and training respecting VAP prevention can improve nurses&#x2019; knowledge and skills and improve care quality. However, most nurses in the above reviewed articles referred to the inadequacy and the ineffectiveness of staff training programs. Many nurses reported that the education they had received in their clinical training was not consistent with the VAP PGs, and more than half of them reported that they never been educated on VAP management courses in their hospitals, and only a third had been educated in the field of mechanical ventilator management based on the VAP PGs (
                    <xref ref-type="bibr" rid="ref4">Aloush &amp; Al-Rawajfa, 2020</xref>). This finding is congruent with the study of 
                    <xref ref-type="bibr" rid="ref1">Al-Sayaghi (2021)</xref>, which reported that a third of nurses never received hospital-based education or training regarding VAP prevention strategies.</p>
                <p>
                    <xref ref-type="bibr" rid="ref46">Yeganeh 
                        <italic toggle="yes">et al.</italic> (2019)</xref> observed compiled education and educational seminars about VAP PGs in only a few units, with minimal educational posters and pamphlets. 
                    <xref ref-type="bibr" rid="ref6">Atashi 
                        <italic toggle="yes">et al.</italic> (2018)</xref> revealed that novice nurses did not obtain adequate VAP training, and consequently felt anxious when providing care to their patients after only a week of supervision under senior nurses in their units during their ICU orientation. This ostensibly indicates a lack of necessary basic training for VAP prevention in such hospitals. In addition, the findings of both observation and interviews indicated that most nurses enrolled in VAP PG programs just to get licenses for career development, without really attending or engaging with the learning process wholeheartedly, with a lack of assessment of program effectiveness for improving nurses&#x2019; performance (
                    <xref ref-type="bibr" rid="ref6">Atashi 
                        <italic toggle="yes">et al.</italic>, 2018</xref>). This indicates that nurses are less likely to adhere to VAP guidelines because of a lack of training courses and effective, sustainable education programs (
                    <xref ref-type="bibr" rid="ref1">Al-Sayaghi, 2021</xref>; 
                    <xref ref-type="bibr" rid="ref3">Aloush 
                        <italic toggle="yes">et al.</italic>, 2018</xref>; 
                    <xref ref-type="bibr" rid="ref21">Jansson 
                        <italic toggle="yes">et al.</italic>, 2018</xref>; 
                    <xref ref-type="bibr" rid="ref45">Yaseen &amp; Salameh, 2015</xref>). Moreover, 
                    <xref ref-type="bibr" rid="ref3">Aloush 
                        <italic toggle="yes">et al.</italic> (2018)</xref> revealed practicing VAP prevention in hospital is not based on research, therefore forming an NCB. Knowledge transfer among nurses is hindered by an inability to translate research into practice (
                    <xref ref-type="bibr" rid="ref3">Aloush 
                        <italic toggle="yes">et al.</italic>, 2018</xref>; 
                    <xref ref-type="bibr" rid="ref7">Bankanie 
                        <italic toggle="yes">et al.</italic>, 2021</xref>), and poor information-sharing between them, which is reflected in poor education and continuing professional education among nurses, associated with low employee satisfaction and QoC delivery (
                    <xref ref-type="bibr" rid="ref7">Bankanie 
                        <italic toggle="yes">et al.</italic>, 2021</xref>).</p>
                <p>Availability of written policies and protocol of nursing care for VAP prevention for MVP is essential and effective in ICUs to enhance nurses&#x2019; adherence with recommended guidelines. Studies found that more than half of the nurses deemed a lack of VAP prevention policy and protocol in their facilities to be a major NCB (
                    <xref ref-type="bibr" rid="ref4">Aloush &amp; Al-Rawajfa, 2020</xref>; 
                    <xref ref-type="bibr" rid="ref6">Atashi 
                        <italic toggle="yes">et al.</italic>, 2018</xref>; 
                    <xref ref-type="bibr" rid="ref14">Hassan &amp; Wahsheh, 2017</xref>; 
                    <xref ref-type="bibr" rid="ref45">Yaseen &amp; Salameh, 2015</xref>). Moreover, nurses in 
                    <xref ref-type="bibr" rid="ref6">Atashi 
                        <italic toggle="yes">et al.</italic>&#x2019;s (2018)</xref> study argued that irrelevant VAP prevention protocols and recommendations established in foreign countries are being applied in settings where they are not necessarily applicable, and they recommended developing new institutionally sensitive guidelines, considering the features of particular settings, such as the number of nurses in shifts, specifications, and equipment availability. On the other hand, 
                    <xref ref-type="bibr" rid="ref3">Aloush 
                        <italic toggle="yes">et al.</italic> (2018)</xref> found that nursing practice in ICUs not being based on research findings (
                    <italic toggle="yes">i.e.</italic>, a lack of evidence-based practice) is an NCB, reflected in nurses&#x2019; lack of awareness of updated knowledge for VAP prevention. Therefore, action is needed by healthcare systems and nurse educators to impart up-to-date evidence-based care, particularly educational sessions to explain protocols and policies for VAP prevention based on evidence-based sources, to help familiarize and orient nurses in order to expedite application of guidelines in practice contexts.</p>
                <p>In addition, healthcare systems need to assess and improve the knowledge and capabilities of nurse educators and senior nurses to enable the diffusion of required VAP prevention knowledge and practice, aside from making training and educational materials available. The supervision of nurses in ICUs regarding their skills is a significant component behind improvement of nurses performance, and a lack of supervision is a barrier commonly identified by nurses themselves (
                    <xref ref-type="bibr" rid="ref6">Atashi 
                        <italic toggle="yes">et al.</italic>, 2018</xref>), and the related issue of the absence of guidance for achieving standard VAP prevention, which is another known NCB (
                    <xref ref-type="bibr" rid="ref3">Aloush 
                        <italic toggle="yes">et al.</italic>, 2018</xref>; 
                    <xref ref-type="bibr" rid="ref20">Jansson 
                        <italic toggle="yes">et al.</italic>, 2013</xref>). Such features could be due to related barriers such as lack of time for monitoring, lack of supervision-related training, and lack of knowledge and abilities for efficient supervision by senior nurses who can guide practice.</p>
                <p>
                    <xref ref-type="bibr" rid="ref6">Atashi 
                        <italic toggle="yes">et al.</italic> (2018)</xref> identified ineffective supervision as a main barrier for effective VAP prevention. Supervisors need to perform many nonsupervisory duties, which prevent them from effectively performing their activities related to supervision. For instance, they were mostly involved in resolving interpersonal conflicts, and making necessary adjustments for patient transfers to other hospitals. Managing educational resources involves the coordination of human and material resources to monitor, plan, strategize, and implement the delivery of education. Based on the reviewed articles, inadequate and inefficient staff training and education at clinical settings suggest the need of hospitals to adhere with the CDC&#x2019;s 2003 recommendations on the importance of conducting education and training programs of nurses in ICUs (
                    <xref ref-type="bibr" rid="ref39">Tablan 
                        <italic toggle="yes">et al.</italic>, 2003</xref>), for effective implementation of VAP prevention strategies.</p>
            </sec>
            <sec id="sec18">
                <title>Ineffective supportive system</title>
                <p>Related to the resource constraints described previously, which are related to hospital management, management&#x2019;s direct support for senior nurses, including managers and supervisors, is also essential for the success of VAP implantation. Four reviewed studies found that insufficient management support is an NCB (
                    <xref ref-type="bibr" rid="ref3">Aloush 
                        <italic toggle="yes">et al.</italic>, 2018</xref>; 
                    <xref ref-type="bibr" rid="ref6">Atashi 
                        <italic toggle="yes">et al.</italic>, 2018</xref>; 
                    <xref ref-type="bibr" rid="ref7">Bankanie 
                        <italic toggle="yes">et al.</italic>, 2021</xref>; 
                    <xref ref-type="bibr" rid="ref11">Dehghan 
                        <italic toggle="yes">et al.</italic>, 2022</xref>; 
                    <xref ref-type="bibr" rid="ref21">Jansson 
                        <italic toggle="yes">et al.</italic>, 2018</xref>). Passive and ineffective management affects the accuracy in task performance of nurses, forming an NCB (
                    <xref ref-type="bibr" rid="ref6">Atashi 
                        <italic toggle="yes">et al.</italic>, 2018</xref>). Other barriers than nurses believed as barriers include limited professional competence, low job motivation, and limited professional accountability, all of which reflect organizational and systemic issues. Nursing managers need to understand how the scarcity of hierarchical support and passive human resource management have impacts on the implementation success of guidelines.</p>
                <p>
                    <xref ref-type="bibr" rid="ref21">Jansson 
                        <italic toggle="yes">et al.</italic> (2018)</xref> reported that passive management was instrumental in nurses&#x2019; ambiguous perceptions of their role in VAP prevention strategies. Role ambiguity was identified as a barrier because nurses are uncertain about their definite tasks in implementing VAP prevention. A lack of clarity about expected roles may cause nurses to struggle, despite their intrinsic role in the evidence-based practice paradigm, the policies of individual hospitals, and of health systems in general, may not be clear for nurses (
                    <italic toggle="yes">e.g.</italic>, whether sedation interruption is a nursing task, or whether only physicians have this authority). Hospital management needs to provide more support by clarifying and setting clear rules and responsibilities for nurses in implementing strategies.</p>
                <p>Moreover most of the nurses in 
                    <xref ref-type="bibr" rid="ref7">Bankanie 
                        <italic toggle="yes">et al.</italic>&#x2019;s (2021)</xref> study noted low &#x201c;job discretion&#x201d; to be a barrier. Nurses are not allowed to make responsible choices, judgments, or decisions with their patients in ICU. This might be as a result of unsupportive system along with job ambiguity in addition to lack of knowledge or skills. Nurses in the study of 
                    <xref ref-type="bibr" rid="ref11">Dehghan 
                        <italic toggle="yes">et al.</italic> (2022)</xref> indicated that a lack of managerial support within the hospitals greatly undermines NC, which is related directly to healthcare organizational systems. These barriers reflect the low quality of working life, and poor organizational culture, which directly influence nurses&#x2019; satisfaction and their readiness to deliver higher QoC.</p>
                <p>The work environment also includes social features within team that can impact workplace relationships, collaboration, efficiency at work, which have impacts on NC. Nurses are the most vital members within healthcare teams, and their role as patient advocates and holistic care specialists is paramount in managing VAP impacts on ICU patients. In this role, nurses must work with each other as peers, and with other healthcare professions such as intensivists and respirologists, to prevent VAP in ICUs. Based on the findings within the review, nurses may be affected by peer influence and teamwork issues.</p>
                <p>Issues of peers and teams significantly influence nursing performance, and adherence with guidelines, which also intersects with the issue of role models; nurses revealed that the lack of professional role models during their working activities comprises an NCB (
                    <xref ref-type="bibr" rid="ref3">Aloush 
                        <italic toggle="yes">et al.</italic>, 2018</xref>). Nurses mentioned that the lack of a team-based approach to care and interventions is a big NCB, which might be due to severe shortages (
                    <xref ref-type="bibr" rid="ref11">Dehghan 
                        <italic toggle="yes">et al.</italic>, 2022</xref>). In their study, 
                    <xref ref-type="bibr" rid="ref6">Atashi 
                        <italic toggle="yes">et al.</italic> (2018)</xref> found that colleagues&#x2019; negative professional attitudes inhibit accurate VAP prevention practice. Participants&#x2019; reports indicated that some colleagues failed to perform their work accurately. They sometimes documented that they performed procedures for VAP prevention when they really did not, such as documenting endotracheal tube cuff pressure without actually measuring it.</p>
            </sec>
            <sec id="sec19">
                <title>Nurse-related barriers</title>
                <p>Nurse-related barriers included issues related to limited personal competences (
                    <italic toggle="yes">e.g.</italic>, education and knowledge, skills, and experience), and situation-related barriers (
                    <italic toggle="yes">e.g.</italic>, concerning the ICU clinical context), which pertain to the essential prerequisites for the success of VAP prevention in ICUs.</p>
                <p>
                    <italic toggle="yes">Limited personal competencies</italic>
                </p>
                <p>Based on the reviewed articles, personal characteristics may be instrumental in NC. The findings showed a lack of NC might be entrenched in nursing education. 
                    <xref ref-type="bibr" rid="ref3">Aloush 
                        <italic toggle="yes">et al.</italic> (2018)</xref> reported that 63% of nurses in their study had received no education about VAP PGs in their nursing education, and the low level of VAP-related education among ICU nurses directly undermined their NC. They also revealed that there was a statistically significant difference based on academic degree, whereby nurses with masters&#x2019; degrees had higher NC in comparison with those with baccalaureate and diploma degrees, which was later affirmed by 
                    <xref ref-type="bibr" rid="ref7">Bankanie 
                        <italic toggle="yes">et al.</italic> (2021)</xref>. 
                    <xref ref-type="bibr" rid="ref4">Aloush and Al-Rawajfa (2020)</xref> reported that the education nurses received during their study was not consistent with VAP PGs, adding a further barrier to their NC. It is important for schools of nursing to consider improving educational programs to improve nurses&#x2019; ICU knowledge and VAP-related education, consistent with clinical guidelines, to subsequently enhance nurses&#x2019; NC and QoC when they transition to clinical practice (
                    <xref ref-type="bibr" rid="ref3">Aloush 
                        <italic toggle="yes">et al.</italic>, 2018</xref>; 
                    <xref ref-type="bibr" rid="ref4">Aloush &amp; Al-Rawajfa, 2020</xref>; 
                    <xref ref-type="bibr" rid="ref45">Yaseen &amp; Salameh, 2015</xref>).</p>
                <p>Some studies reported a lack of skills to be an NCB. 
                    <xref ref-type="bibr" rid="ref20">Jansson 
                        <italic toggle="yes">et al.</italic> (2013)</xref> and 
                    <xref ref-type="bibr" rid="ref7">Bankanie 
                        <italic toggle="yes">et al.</italic> (2021)</xref> stated that a lack of skills among nurses was a significant barrier to compliance with guidelines for VAP prevention, and they called for ongoing educational interventions and effective strategies to facilitate knowledge and skills dissemination and transfer in the workplace. Almost a quarter (23%) of nurses &#x201c;strongly disagreed&#x201d; that a lack of skills was considered a barrier in a study by 
                    <xref ref-type="bibr" rid="ref4">Aloush and Al-Rawajfa (2020)</xref>, but this may reflect social desirability bias (
                    <italic toggle="yes">i.e.</italic>, nurses not wishing to acknowledge to others or to themselves that they lacked the required skills for serious interventions due to perceiving this to be a personal rather than systemic and educational shortcoming).</p>
                <p>
                    <xref ref-type="bibr" rid="ref3">Aloush 
                        <italic toggle="yes">et al.</italic> (2018)</xref> reported that years of experience was a significant indicator for increased NC, and numerous other studies found that less experienced nurses had lower NC in Middle Eastern contexts (
                    <xref ref-type="bibr" rid="ref4">Aloush &amp; Al-Rawajfa, 2020</xref>; 
                    <xref ref-type="bibr" rid="ref45">Yaseen &amp; Salameh, 2015</xref>); conversely, 
                    <xref ref-type="bibr" rid="ref20 ref21">Jansson 
                        <italic toggle="yes">et al.</italic> (2013, 2018)</xref> found no relation between NC and longer work experience in Finland.</p>
            </sec>
            <sec id="sec20">
                <title>Situation-related barriers</title>
                <p>Some nurses questioned the importance of VAP prevention measures to patient well-being because, in certain clinical situations, they were required to make appropriate judgments and timely decisions when encountering patients with serious physiological issues. The reason for these concerns could be that certain clinical guidelines do not adequately consider individual patient needs and capabilities (
                    <xref ref-type="bibr" rid="ref21">Jansson 
                        <italic toggle="yes">et al.</italic>, 2018</xref>). Unpredictable adverse effects harming patients, and undesirable patient outcomes from some VAP preventive procedures, were cited as dreaded outcomes by nurses in many studies (
                    <xref ref-type="bibr" rid="ref1">Al-Sayaghi, 2021</xref>; 
                    <xref ref-type="bibr" rid="ref11">Dehghan 
                        <italic toggle="yes">et al.</italic>, 2022</xref>; 
                    <xref ref-type="bibr" rid="ref14">Hassan &amp; Wahsheh, 2017</xref>; 
                    <xref ref-type="bibr" rid="ref21">Jansson 
                        <italic toggle="yes">et al.</italic>, 2018</xref>; 
                    <xref ref-type="bibr" rid="ref35">Ricart 
                        <italic toggle="yes">et al.</italic>, 2003</xref>).</p>
                <p>
                    <xref ref-type="bibr" rid="ref21">Jansson 
                        <italic toggle="yes">et al.</italic> (2018)</xref> reported that nurses&#x2019; concerns regarding the impacts of VAP prevention procedures may have hindered adherence with appropriate strategies. In particular, nurses were doubtful of the indications of sedation, and worried about over-sedation that might harm patients. They also were worried about potential mistakes due to keeping their patients in a semi-recumbent position, as it is difficult to estimate the appropriate angle of the head of the bed. Uncertainty about indications of enhanced oral care, the estimated depth during endotracheal suctioning, and the duration of suctioning added to their fear of potential complications. Other studies reported that nurses were commonly concerned about the detachment of attached tubes during certain VAP prevention procedures (
                    <xref ref-type="bibr" rid="ref11">Dehghan 
                        <italic toggle="yes">et al.</italic>, 2022</xref>). These concerns might be because of the fear of committing mistakes 
                    <italic toggle="yes">per se</italic>; producing undesired alterations in hemodynamic status of patients; or the belief that performing VAP measures could cause deterioration in the critical status of patients. These concerns made the nurses more cognizant of their patients&#x2019; holistic needs, and they experienced a dilemma between the biomedical mandates of VAP prevention and what they perceived to be their nursing duty of safeguarding patients holistically, which resulted in noncompliance with some VAP preventive measures.</p>
            </sec>
        </sec>
        <sec id="sec21" sec-type="conclusion">
            <title>Conclusion</title>
            <p>Common barriers appear to inhibit nurses from performing appropriate VAP prevention strategies. This review highlighted the intricate correlated barriers that inhibit NC with evidence-based VAP prevention strategies. The aim of this review to identify gap in literature to guide future research. The ICU work environment and hospital management play major roles in creating low NC, without appropriate measures to address nursing and situational impediments to compliance, such as the effects of attitudes and behaviors, efficacy, low job motivation, peer influence and team dynamics, all of which need further scrutiny and clarification. Contextual and work environment barriers are relatively under-reported, and warrant further exploration, but it is clear that the work environment is the base issue that triggers multiple NCBs, beyond the control of individual nurses.</p>
            <p>Moreover, future use of different methodological approaches, such as mixed-methods studies and more exploratory qualitative studies, can gain more in-depth insights, and find out the thorough predisposing barriers formulating a solid literature. Mixed-method designs might be beneficial to identify factors that affected NC. For instance, an observational study followed by qualitative study, or conducting a qualitative study to discover the barriers, followed by administration of a self-reported survey created based on the qualitative findings, would provide a robust research approach. Comparative studies of hospitals with zero VAP rate and high VAP rate within same and/or other country are essential to solidly elucidate real barriers. Follow-up studies to identify the barriers, plan and then implement changes to improve NC and monitor related KPIs (particularly VAP rate) would clarify systemic and long-term barriers more fully. Such future research may help to solidly elucidate all barriers that might be essential for nurse leaders and policy makers, particularly if various types of study are conducted within the same local context.</p>
            <p>This scoping review can be used as a template for future studies, representing the key concepts underpinning NCBs among nurses in intensive care units according to current evidence. Further primary research about barriers would be beneficial to support nursing leaders and healthcare systems in augmenting compliance and informing practice, to positively influence QoC for MVPs, empowering nurses to able to identify and control their own barriers.</p>
            <sec id="sec22">
                <title>Strengths and limitations</title>
                <p>The duration of the search encompassed works published since 2003, which was included all recent works published in English. The numerous specializations involved in intensive care units allow generalization of the findings of this study for all CCNs, in terms of barriers hindering nursing compliance with VAP prevention strategies. Moreover, this is the first scoping review that considered a standalone study for future research using a rigorous PRISMA-ScR report, adding more strength to the review.</p>
                <p>However, this scoping review also has some limitations. To make it more feasible, this review included only published, peer reviewed research articles in English language, available in full-text form. These criteria may have led to missing some relevant studies and information. Future reviews may further include other types of literature, such as grey literature, reports, dissertations, and editorials, and works in non-English languages. Future reviews in this topic may compare published findings with those of unpublished literature.</p>
            </sec>
        </sec>
    </body>
    <back>
        <sec id="sec25" sec-type="data-availability">
            <title>Data availability</title>
            <sec id="sec26">
                <title>Underlying data</title>
                <p>Figshare: Barriers to compliance with evidence-based guidelines for ventilator-associated pneumonia among critical care nurses: A scoping review (
                    <xref ref-type="bibr" rid="ref2">Al-Tamimi 
                        <italic toggle="yes">et al</italic>., 2022</xref>). 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.6084/m9.figshare.21493122">https://doi.org/10.6084/m9.figshare.21493122</ext-link>
                </p>
                <p>The project contains the following underlying data:</p>
                <p>Search Strategy. File 1-
 PubMed search strategy performed June 13, 2022</p>
            </sec>
            <sec id="sec27">
                <title>Extended data</title>
                <p>Repository name: Figshare: 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.6084/m9.figshare.21493122">https://doi.org/10.6084/m9.figshare.21493122</ext-link>
                </p>
                <p>This project contains the following extended data:
                    <list list-type="bullet">
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Data extraction form. Summary review of included studies)</p>
                        </list-item>
                    </list>
                </p>
            </sec>
            <sec id="sec28">
                <title>Reporting guidelines</title>
                <p>Figshare: PRISMA-Scr checklist for &#x2018;Barriers to compliance with evidence-based guidelines for ventilator-associated pneumonia among critical care nurses: A scoping review&#x2019;. 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.6084/m9.figshare.21493122">https://doi.org/10.6084/m9.figshare.21493122</ext-link>
                </p>
                <p>Data are available under the terms of the 
                    <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/1.0/">Creative Commons Zero &#x201c;No rights reserved&#x201d; data waiver</ext-link> (CC0 1.0 Public domain dedication).</p>
            </sec>
        </sec>
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    </back>
    <sub-article article-type="reviewer-report" id="report158511">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.140706.r158511</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Alrimawi</surname>
                        <given-names>Intima</given-names>
                    </name>
                    <xref ref-type="aff" rid="r158511a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0001-8683-9541</uri>
                </contrib>
                <aff id="r158511a1">
                    <label>1</label>Nursing, Georgetown University, Washington, District of Columbia, USA</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>16</day>
                <month>1</month>
                <year>2023</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2023 Alrimawi I</copyright-statement>
                <copyright-year>2023</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport158511" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.128144.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>This scoping review discusses the topic of barriers to compliance with evidence-based guidelines for ventilator-associated pneumonia among critical care nurses. This is a very important topic that was not covered in other scoping reviews.&#x00a0;</p>
            <p> </p>
            <p> In the methodology section the researcher thoroughly discussed the scientific approach that they followed to conduct this review.&#x00a0;</p>
            <p> </p>
            <p> The results section needs to be developed further; additional discussion is needed around the selected studies and the final themes that did emerge from them.</p>
            <p> </p>
            <p> The discussion section needs to take the themes to the next level and discuss the potential implication and recommendations to recommend these barriers. For example, if you think that lack of staff and time was a barrier, then what is the implication of this in the current practice, and how can we overcome this barrier on the ground?&#x00a0;</p>
            <p> </p>
            <p> The conclusion section is long, it needs to be summarized and be more focused.</p>
            <p> </p>
            <p> You can also add a separate recommendation section.&#x00a0;</p>
            <p> </p>
            <p> </p>
            <p> </p>
            <p> </p>
            <p> </p>
            <p>Are the rationale for, and objectives of, the Systematic Review clearly stated?</p>
            <p>Yes</p>
            <p>Is the statistical analysis and its interpretation appropriate?</p>
            <p>Not applicable</p>
            <p>Are sufficient details of the methods and analysis provided to allow replication by others?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results presented in the review?</p>
            <p>Yes</p>
            <p>Reviewer Expertise:</p>
            <p>Her research focuses on improving the quality of care for vulnerable families and children with complex health concerns and critical illness and developing nursing education, mainly in low and middle-income countries.</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.</p>
        </body>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report158512">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.140706.r158512</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Mohammed Al-Sayaghi</surname>
                        <given-names>Khaled</given-names>
                    </name>
                    <xref ref-type="aff" rid="r158512a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-9508-3050</uri>
                </contrib>
                <aff id="r158512a1">
                    <label>1</label>Critical Care and Emergency Nursing, College of Nursing, Taibah University, Madinah, Saudi Arabia</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>16</day>
                <month>1</month>
                <year>2023</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2023 Mohammed Al-Sayaghi K</copyright-statement>
                <copyright-year>2023</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport158512" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.128144.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>Overall the review is so good. It provides information about the barriers to compliance with evidence-based guidelines for VAP among critical care nurses. It considered one of the important topics in the critical care nursing. I thank the authors for choosing this important topic. Kindly consider the following comments: 
                <list list-type="order">
                    <list-item>
                        <p>The small paragraphs in the introduction can be merged into 4 large paragraphs.</p>
                    </list-item>
                    <list-item>
                        <p>Has the systematic review been registered in specific institutions such as PROSPERO?</p>
                    </list-item>
                    <list-item>
                        <p>When conducting a systematic review, it is normal to provide some additional information on the search methodology (search strategy).</p>
                    </list-item>
                    <list-item>
                        <p>Regarding the search strategy, I see that synonyms of the keywords for the research topic can be helpful. Synonyms provide access to all the research published on the subject of the research, for example, barriers may use factors, nurse may use health care workers, guideline may use bundle, compliance may use adherence, intensive care may use critical care, etc. The use of the single term is likely to miss quite a lot of the literature on this subject.</p>
                    </list-item>
                    <list-item>
                        <p>Is it possible to pool the effect size of each compliance barriers among critical care nurses by meta-analysis? If not, please explain the reasons.</p>
                    </list-item>
                    <list-item>
                        <p>The researchers in the discussion did not talk about the secondary research that dealt with the subject in some detail and how this study differs from previous reviews.</p>
                    </list-item>
                    <list-item>
                        <p>You need to provide operational definitions for each barrier you mentioned in the results.</p>
                    </list-item>
                    <list-item>
                        <p>The work environment-related barriers were categorized into several subcategories. If possible, categorize the &#x201c;Nurse-related barriers&#x201d; and &#x201c;Situation-related barriers&#x201d;.</p>
                    </list-item>
                    <list-item>
                        <p>Page 13, line 11: &#x201c;Limited personal competencies&#x201d; is the only subcategory under the &#x201c;Nurse-related barriers&#x201d;. If it is not possible to add other subcategories, it is better to remove the subtitle.</p>
                    </list-item>
                    <list-item>
                        <p>Page 14: there is a redundancy in the second and third paragraphs of conclusions. It needs to be summarized in one small paragraph.</p>
                    </list-item>
                    <list-item>
                        <p>You need to add a subheading about implications for nursing.</p>
                    </list-item>
                    <list-item>
                        <p>The paper needs professional English editing.</p>
                    </list-item>
                </list>
            </p>
            <p>Are the rationale for, and objectives of, the Systematic Review clearly stated?</p>
            <p>Yes</p>
            <p>Is the statistical analysis and its interpretation appropriate?</p>
            <p>Yes</p>
            <p>Are sufficient details of the methods and analysis provided to allow replication by others?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results presented in the review?</p>
            <p>Yes</p>
            <p>Reviewer Expertise:</p>
            <p>Critical Care Nursing, infection control practices, nutritional support in critical care, and mechanical ventilation</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
        <sub-article article-type="response" id="comment9472-158512">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Al-Tamimi</surname>
                            <given-names>Muna</given-names>
                        </name>
                        <aff>University of Sharjah, United Arab Emirates</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>16</day>
                    <month>3</month>
                    <year>2023</year>
                </pub-date>
            </front-stub>
            <body>
                <p>Dear Dr. al-Sayaghi,</p>
                <p> </p>
                <p> Thank you for facilitating the peer review. The revised version of the scoping review has been uploaded, and we have addressed all of Dr. al-Sayaghi's comments to further improve the quality of our paper. In response to each comment, we have provided the following responses:</p>
                <p> </p>
                <p> 1. The small paragraphs in the introduction can be merged into 4 large paragraphs.</p>
                <p> </p>
                <p> We have merged the paragraphs as the following: Changes within the new version.</p>
                <p> Nurses play a pivotal role in providing safe and direct care to MVPs, including practicing VAP prevention strategies that are essential to prevent infection and therefore improve the quality of patient care and outcomes in ICUs (Jansson et al., 2013; Osti et al., 2017) According to Pogorzelska et al. (2011), nursing compliance with VAP prevention guidelines in ICUs (hereinafter &#x201c;NC&#x201d;) should be at least 95%, in order to effectively reduce VAP incidence. Therefore, strict compliance with strategies and recommendations is required from nurses, who must appropriately perform several interventions and procedures to achieve optimum outcomes (Miranda da Cruz &amp; da Silva Martins, 2019; Rello et al., 2013; Tabaeian et al., 2017). Facilitating and promoting changes in patient care, and encouraging NC are crucial for VAP prevention success, and also providing regular feedback on process measure performance and outcome rates are among the best practices to facilitate adherence to guidelines (Crunden et al., 2005; Klompas, 2017).</p>
                <p> </p>
                <p> In spite of the existence of clinical practice guidelines for preventing VAP, these guidelines are not consistently followed (Cason et al., 2007; Ricart et al., 2003). Reported levels of compliance with and proper use of strategies vary widely in various contexts, across health systems, specialties, and nurses, ranging from 20% to nearly 100% (Beattie et al., 2012; Bird et al., 2010; Rello et al., 2002). Several studies showed that nurses generally exhibit low NC, which could be attributable to diverse factors (Aloush et al., 2018; Aloush &amp; Al-Rawajfa, 2020;Jahansefat et al., 2016;Jam et al., 2018). Given the critical impact of NC on patients&#x2019; QoC, it is essential to identify the factors influencing it that might impede the proper implementation of EBGs, and hence affect patient outcomes.</p>
                <p> </p>
                <p> &#x00a0;2.&#x00a0;Has the systematic review been registered in specific institutions such as PROSPERO</p>
                <p> </p>
                <p> This scoping review follows Joanna Briggs Institute (JBI) Manual for Evidence Synthesis. Available in&#x00a0;
                    <ext-link ext-link-type="uri" xlink:href="https://jbi-global-wiki.refined.site/space/MANUAL/4687810/11.2+Development+of+a+scoping+review+protocol">https://jbi-global-wiki.refined.site/space/MANUAL/4687810/11.2+Development+of+a+scoping+review+protocol</ext-link>
                </p>
                <p> </p>
                <p> Therefore, it was not registered in PROSPERO, however, this scoping review is registered with Figshare (
                    <ext-link ext-link-type="uri" xlink:href="https://figshare.com/">&#x00a0;https://figshare.com</ext-link>
                    <underline>) </underline>as following details:</p>
                <p> </p>
                <p> Data availability:</p>
                <p> Underlying data Al-Tamimi et al., 2022</p>
                <p> Figshare:&#x00a0;Barriers to compliance with evidence-based guidelines for ventilator-associated pneumonia among critical care nurses: A scoping review. 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.6084/m9.figshare.21493122">https://doi.org/10.6084/m9.figshare.21493122</ext-link>
                </p>
                <p> The project contains the following underlying data:</p>
                <p> Search Strategy. File 1- PubMed search strategy performed June 13, 2022</p>
                <p> Extended data</p>
                <p> Repository name: Figshare:&#x00a0;
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.6084/m9.figshare.21493122">https://doi.org/10.6084/m9.figshare.21493122</ext-link>
                </p>
                <p> This project contains the following extended data:</p>
                <p> Data extraction form. Summary review of included studies.</p>
                <p> Reporting guidelines</p>
                <p> Figshare: PRISMA-Scr checklist for &#x2018;Barriers to compliance with evidence-based guidelines for ventilator-associated pneumonia among critical care nurses: A scoping review&#x2019;.&#x00a0;
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.6084/m9.figshare.21493122">https://doi.org/10.6084/m9.figshare.21493122</ext-link>
                </p>
                <p> Data are available under the terms of the Creative Commons Zero "No rights reserved" data waiver (CC0 1.0 Public domain dedication).</p>
                <p> </p>
                <p> 3. When conducting a systematic review, it is normal to provide some additional information on the search methodology (search strategy).</p>
                <p> </p>
                <p> The detailed PubMed search strategy is available as an additional file in the data availability "Underlying data&#x201d;. Search Strategy. File 1- PubMed search strategy performed June 13, 2022</p>
                <p> It can also be accessed through the extended data: Repository name: Figshare: 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.6084/m9.figshare.21493122">https://doi.org/10.6084/m9.figshare.21493122</ext-link>
                </p>
                <p> </p>
                <p> 4. Regarding the search strategy, I see that synonyms of the keywords for the research topic can be helpful. Synonyms provide access to all the research published on the subject of the research, for example, barriers may use factors, nurse may use health care workers, a guideline may use bundle, compliance may use adherence, intensive care may use critical care, etc. The use of the single term is likely to miss quite a lot of the literature on this subject.</p>
                <p> </p>
                <p> Following PRISMA-ScR checklist, we added one full electronic search strategy of Pubmed. This information is available in F1000Research Search Strategy. File 1- PubMed search strategy performed June 13, 2022. And in the Extended data Repository name: Figshare:&#x00a0;
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.6084/m9.figshare.21493122">https://doi.org/10.6084/m9.figshare.21493122</ext-link>. However, search strategies of the other databases (scopus and CINHAL) are available upon request that includes other synonyms. Therefore, the following sentence is added to clarify this point.</p>
                <p> </p>
                <p> &#x00a0;&#x201c;Additional search strategies are available upon request from the corresponding author&#x201d;.</p>
                <p> </p>
                <p> 5. Is it possible to pool the effect size of each compliance barriers among critical care nurses by meta-analysis? If not, please explain the reasons.</p>
                <p> </p>
                <p> As per the followed JBI guidelines, meta-analysis was not conducted for the scoping review paper.</p>
                <p> 
                    <ext-link ext-link-type="uri" xlink:href="https://jbi-global-wiki.refined.site/space/MANUAL/4687681/11.2.8+Analysis+of+the+evidence">https://jbi-global-wiki.refined.site/space/MANUAL/4687681/11.2.8+Analysis+of+the+evidence</ext-link>
                </p>
                <p> </p>
                <p> 6.&#x00a0;The researchers in the discussion did not talk about the secondary research that dealt with the subject in some detail and how this study differs from previous reviews.</p>
                <p> </p>
                <p> This first scoping review is considered a standalone study for future research using a rigorous PRISMA-ScR report. It includes peer-reviewed internationally published articles that mainly focus on barriers toward compliance with evidence-based guidelines for ventilator-associated pneumonia among critical care nurses. It aims to examine the characteristics of studies, identify, and summarize key findings of related studies; and identify gaps in extant studies that may help inform future research in this area. These aims are prominent for any scoping review paper.</p>
                <p> </p>
                <p> 7. You need to provide operational definitions for each barrier you mentioned in the results.</p>
                <p> </p>
                <p> The comment is taken into consideration by adding the following operational definitions for each barrier.</p>
                <p> </p>
                <p> Changes within the new version.</p>
                <p> </p>
                <p> Work environment-related barriers: Barriers related to the work environment are those beyond the control of individual nurses (Jansson 
                    <italic>et al.</italic> 2018). These include significant challenges in the workforce that hinder nurses from complying with VAP prevention EBGs.</p>
                <p> </p>
                <p> Nurse-related barriers: These barriers are nurse-related characteristics that limit the nurse's ability to follow the guidelines (Aloush et al., 2018; Yaseen &amp; Salameh, 2015).</p>
                <p> </p>
                <p> Situation-related barriers are factors related to patients that hinder nurses&#x2019; compliance toward VAP guidelines (Jansson 
                    <italic>et al.,</italic> 2018; Ricart 
                    <italic>et al.,</italic> 2003) and the doubts that can influence nurses&#x2019; behavior toward these guidelines (Dehghan 
                    <italic>et al.</italic>, 2022; Jansson 
                    <italic>et al., </italic>2018).</p>
                <p> </p>
                <p> 8. Work environment-related barriers were categorized into several subcategories. If possible, categorize the &#x201c;Nurse-related barriers&#x201d; and &#x201c;Situation-related barriers</p>
                <p> </p>
                <p> Based on the revised articles and synthesis of results, further categorization to the &#x201c;Nurse-related barriers&#x201d; and &#x201c;Situation-related barriers was not viable.</p>
                <p> </p>
                <p> 9. Page 13, line 11: &#x201c;Limited personal competencies&#x201d; is the only subcategory under the &#x201c;Nurse-related barriers&#x201d;. If it is not possible to add other subcategories, it is better to remove the subtitle.</p>
                <p> </p>
                <p> The comment is considered. subtitle removed.</p>
                <p> </p>
                <p> 10. Page 14: there is a redundancy in the second and third paragraphs of conclusions. It needs to be summarized in one small paragraph.</p>
                <p> &#x00a0;&#x00a0;</p>
                <p> A summary of the conclusion is conducted as per the recommendation as follows;</p>
                <p> </p>
                <p> This scoping review can be used as a template for future studies, representing the key concepts underpinning NCBs among nurses in intensive care units. Further primary research about barriers using different methodological approaches, such as mixed-methods studies and more exploratory qualitative studies can gain more in-depth insights and find out the thorough predisposing barriers formulating a solid literature. Comparative studies of hospitals with zero VAP rate and high VAP rate within the same and/or other countries are essential to solidly elucidate real barriers. Follow-up studies to identify the barriers, plan and then implement changes to improve NC, and monitor related KPIs (particularly VAP rate) would clarify systemic and long-term barriers more fully. Such research may help to solidly elucidate all barriers that might be essential for nurse leaders, and policymakers particularly if various types of study are conducted within the same local context. It would be beneficial to support nursing leaders and healthcare systems in augmenting compliance and informing practice, positively influencing QoC for MVPs, and empowering nurses to able to identify and control their own barriers.</p>
                <p> </p>
                <p> 11. You need to add a subheading about implications for nursing.</p>
                <p> </p>
                <p> Implications were included in the conclusion (as per PRISMA-ScR checklist).</p>
                <p> </p>
                <p> 12. The paper needs professional English editing
                    <bold>.</bold>&#x00a0;&#x00a0;&#x00a0;&#x00a0;&#x00a0;&#x00a0;&#x00a0;&#x00a0;&#x00a0;&#x00a0;</p>
                <p> </p>
                <p> The paper has been professionally edited by a native speaker (UK).</p>
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