<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN" "http://jats.nlm.nih.gov/publishing/1.2/JATS-journalpublishing1.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="research-article" dtd-version="1.2" xml:lang="en">
    <front>
        <journal-meta>
            <journal-id journal-id-type="pmc">F1000Research</journal-id>
            <journal-title-group>
                <journal-title>F1000Research</journal-title>
            </journal-title-group>
            <issn pub-type="epub">2046-1402</issn>
            <publisher>
                <publisher-name>F1000 Research Limited</publisher-name>
                <publisher-loc>London, UK</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="doi">10.12688/f1000research.141705.1</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Research Article</subject>
                </subj-group>
                <subj-group>
                    <subject>Articles</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Relationship between eating disorders and pain levels before and after implantation with personality type&#x202f;</article-title>
                <fn-group content-type="pub-status">
                    <fn>
                        <p>[version 1; peer review: 1 approved with reservations]</p>
                    </fn>
                </fn-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author" corresp="yes">
                    <name>
                        <surname>Bakkalo&#x011f;lu</surname>
                        <given-names>Halil</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Funding Acquisition</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <uri content-type="orcid">https://orcid.org/0000-0001-6165-3038</uri>
                    <xref ref-type="corresp" rid="c1">a</xref>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <aff id="a1">
                    <label>1</label>Dentistry, Cyprus Health and Social Sciences University, Faculty of Dentistry, Morphou (Guzelyurt), TRNC via Mersin 10, Mersin, Turkey, Morphou (Guzelyurt), Cyprus</aff>
            </contrib-group>
            <author-notes>
                <corresp id="c1">
                    <label>a</label>
                    <email xlink:href="mailto:halil.bakkaloglu@kstu.edu.tr">halil.bakkaloglu@kstu.edu.tr</email>
                </corresp>
                <fn fn-type="conflict">
                    <p>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>17</day>
                <month>10</month>
                <year>2023</year>
            </pub-date>
            <pub-date pub-type="collection">
                <year>2023</year>
            </pub-date>
            <volume>12</volume>
            <elocation-id>1348</elocation-id>
            <history>
                <date date-type="accepted">
                    <day>11</day>
                    <month>10</month>
                    <year>2023</year>
                </date>
            </history>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2023 Bakkalo&#x011f;lu H</copyright-statement>
                <copyright-year>2023</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <self-uri content-type="pdf" xlink:href="https://f1000research.com/articles/12-1348/pdf"/>
            <abstract>
                <sec>
                    <title>Background</title>
                    <p>In this study, it was aimed to examine the relationship between eating disorders and pain levels before and after implantation in dental patients.</p>
                </sec>
                <sec>
                    <title>Methods</title>
                    <p>A pre-implant and post-implant questionnaire was applied to 223 patients who applied to Cyprus Health and Social Sciences University and underwent implant application. Personal information form, Rezz Eating Disorders Scale and Five Factor Personality Types Scale were applied to the patients in the survey application.</p>
                </sec>
                <sec>
                    <title>Results</title>
                    <p>Extroversion and neuroticism personality type levels of patients were significantly higher after implant (p&lt;0.05). Pain, eating disorder and other personality type differences between before and after implant were statistically insignificant (p&gt;0.05). Before implant, pain level was positively correlated with eating disorder (r=0.190; p&lt;0.01) and negatively correlated with self-control (r=-0.169; p&lt;0.01). Eating disorder level was positively correlated with pain (r=0.190; p&lt;0.01); negatively correlated with extroversion (r=-0.187; p&lt;0.01) and self-control (r=-0.178; p&lt;0.01). After implant, pain level was negatively correlated with neuroticism (r=-0.140; p&lt;0.05) and openness to experience (r=-0.136; p&lt;0.05). Eating disorder level was negatively correlated with extroversion (r=-0.237; p&lt;0.01), self-control (r=-0.151; p&lt;0.05) and neuroticism (r=-0.187; p&lt;0.01). Extroversion personality type level had significant and negative effect on eating disorder after implant at multivariate level (B=-0.43; p&lt;0.01).</p>
                </sec>
                <sec>
                    <title>Conclusions</title>
                    <p>After the implant, psychological support can be given to improve the extrovert personality structures in order to reduce the eating disorder levels of the patients and to prevent the possibility of eating disorders.</p>
                </sec>
            </abstract>
            <kwd-group kwd-group-type="author">
                <kwd>Implant</kwd>
                <kwd>eating disorders</kwd>
                <kwd>pain</kwd>
                <kwd>personality types</kwd>
            </kwd-group>
            <funding-group>
                <funding-statement>The author(s) declared that no grants were involved in supporting this work.</funding-statement>
            </funding-group>
        </article-meta>
    </front>
    <body>
        <sec id="sec1" sec-type="intro">
            <title>Introduction</title>
            <p>Dental implant treatment is an increasingly used method in oral and dental health in recent years. Thanks to dental implants, patients regain the functional part of their oral and dental health that they have lost permanently. Thanks to dental implant treatment, important gains are provided in terms of both the quality of life and aesthetic appearance of the patients, especially in nutrition.
                <sup>
                    <xref ref-type="bibr" rid="ref1">1</xref>
                </sup>
                <sup>&#x2013;</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref3">3</xref>
                </sup> For this reason, patients are using more and more implant options every day and thus regain their oral and dental health.</p>
            <p>Another issue where oral and dental health is important is nutrition. Nutrition begins in the mouth and is activated by the grinding of solid foods by the teeth. Therefore, oral and dental health is of great importance, especially in solid food intake. However, in studies on oral health, there are studies reporting that nutritional disorders are seen in individuals due to problems such as dental caries or tissue in the mouth.
                <sup>
                    <xref ref-type="bibr" rid="ref4">4</xref>
                </sup>
                <sup>&#x2013;</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref6">6</xref>
                </sup> The common point of these studies is that there is a relationship between oral and dental health and eating disorders and those eating disorders affect both physically and psychologically.</p>
            <p>Eating disorders are not only related to oral and dental health in general, but also have psychological roots. In the absence of a physical problem, individuals&#x2019; eating disorders are related to their psychological state and mental health.
                <sup>
                    <xref ref-type="bibr" rid="ref7">7</xref>
                </sup>
                <sup>&#x2013;</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref10">10</xref>
                </sup> Based on the cognitive side of every mental health issue, it is possible to state that the personality structures of individuals are also related to eating disorders. Therefore, personality types, which are indicators of personality structure, have a significant effect on eating disorders, as well as other cognitive factors.</p>
            <p>Although eating disorders are examined according to various variables and personality structure or mental health parameters in the literature, there are not enough studies related to eating disorders and oral health. Therefore, in this study, it was aimed to examine the relationships between personality types, eating disorders and pain perception levels of patients before and after implantation.</p>
        </sec>
        <sec id="sec2" sec-type="methods">
            <title>Methods</title>
            <sec id="sec3">
                <title>Study design</title>
                <p>A pre-implant and post-implant questionnaire was applied to 223 patients who applied to Cyprus Health and Social Sciences University and underwent implant application. A personal information form (including gender, age, working status, BMI, eating disorder history, implant history, dental fear and dental care), Rezz Eating Disorders Scale and Five Factor Personality Types Scale were applied to the patients in the survey application. Research questionnaire was applied paper between June 2023 and August 2023. Before the application of the questionnaire, permission was obtained from the Scientific Ethics Committee of Cyprus University of Health and Social Sciences.</p>
            </sec>
            <sec id="sec4">
                <title>Sample</title>
                <p>A total of 223 patients were voluntarily subjected to the study among reached 248 patients during the research period, between June 2023 and August 2023. Since the research is a pioneer, and there have not been reference study for power analysis, sample size calculation was not suitable for the research. By conducting full census sampling in the relevant period, everyone who had an implant within three months and volunteered to participate in the study was included in the study. Time-based sampling method was used.</p>
                <p>The inclusion criteria of the patients were determined as follows:
                    <list list-type="bullet">
                        <list-item>
                            <label>&#x2013;</label>
                            <p>18 years and over</p>
                        </list-item>
                        <list-item>
                            <label>&#x2013;</label>
                            <p>Not having a chronic disease that prevents the research,</p>
                        </list-item>
                        <list-item>
                            <label>&#x2013;</label>
                            <p>Not having a psychiatric or psychological diagnosis,</p>
                        </list-item>
                        <list-item>
                            <label>&#x2013;</label>
                            <p>Volunteer to participate in the research.</p>
                        </list-item>
                    </list>
                </p>
            </sec>
            <sec id="sec5">
                <title>Rezz Eating Disorders Scale</title>
                <p>The scale, which was validated in Turkish by Aydemir 
                    <italic toggle="yes">et al.</italic>,
                    <sup>
                        <xref ref-type="bibr" rid="ref11">11</xref>
                    </sup> measures eating disorder in a five-point Likert type and one dimension. Scoring of the scale is from 1 to 5, and total score shows eating disorder levels of participants. The Cronbach Alpha internal consistency coefficient of the scale was reported as 0.74. In this research, we found Cronbach Alpha as 0.754.</p>
            </sec>
            <sec id="sec6">
                <title>Five Factor Personality Types Scale</title>
                <p>The scale, which was validated in Turkish by Horzum 
                    <italic toggle="yes">et al.</italic>,
                    <sup>
                        <xref ref-type="bibr" rid="ref12">12</xref>
                    </sup> examines personality types in a five-point Likert type and five dimensions. These are extroversion, agreeableness, self-control, neuroticism, and openness to experience. The Cronbach alpha internal consistency value of the scale was reported as 0.88 for extraversion, 0.81 for agreeableness, 0.90 for self-controlling, 0.85 for neuroticism, and 0.84 for openness to experience. In this research, we found Cronbach Alpha 0.728 for extraversion, 0.779 for agreeableness, 0.818 for self-controlling, 0.815 for neuroticism, and 0.886 for openness to experience.</p>
            </sec>
            <sec id="sec7">
                <title>Visual Analog Scale (VAS)</title>
                <p>A high score on the scale, which measures the pain threshold on a scale from 1 to 10, indicates a high level of pain.</p>
            </sec>
            <sec id="sec8">
                <title>Study procedure</title>
                <p>In the study, patients who had implants and met the inclusion criteria given above were included in the study on a voluntary basis, without any preliminary evaluation. Participants were asked to fill out the survey by choosing the answers that best suited them.</p>
            </sec>
            <sec id="sec9">
                <title>Ethical approval</title>
                <p>Ethical approval was taken from Scientific Ethics Committee of Cyprus University of Health and Social Sciences with KSTU/2023/202 grant number on 13.05.2023. Written consent from all participants was taken according to ethical approval.</p>
            </sec>
            <sec id="sec10">
                <title>Statistical methods</title>
                <p>Frequency analysis was used for description of nominal and ordinal parameters. Means and standard deviations were used for description of scale parameters. Cronbach Alpha was used for reliability analysis. Kolmogorov Smirnov test was used for normality of scale parameters. Since all parameter distributions were not normal, nonparametric tests were used. Wilcoxon Signed Rank test was used for differences between before and after implant. Spearman&#x2019;s rho correlation and Generalized Linear Model (Logit) was used for relationship analysis.
                    <sup>
                        <xref ref-type="bibr" rid="ref13">13</xref>
                    </sup> 
                    <ext-link ext-link-type="uri" xlink:href="https://www.ibm.com/products/spss-statistics">SPSS</ext-link> 25.0 for windows was used at 95% Confidence Interval and 0.05 significance level.</p>
            </sec>
        </sec>
        <sec id="sec11" sec-type="results">
            <title>Results</title>
            <p>In total, 248 patients were eligible for the research between June 2023 and August 2023, and 223 of them were respondents.
                <sup>
                    <xref ref-type="bibr" rid="ref26">26</xref>
                </sup> Before implant, voluntary method was used for participation. Similarly, patients were asked to participate after implant by voluntary method. For gender distribution, 49.8% of participants were female and 50.2% were male. According to age distribution, 31.1% had 25 and under, 32.0% had 26-35, 36.9% had 36 and over ages. 61.9% of patients were working. 73.1% had normal, 23.3% had overweight and 3.6 had obese BMI level. 12.1% had eating disorder in the family, 3.6% had implant history, 22.0% had oral and maxillofacial surgery history, 19.7% had dentist fear and 83.4% had regular oral care (
                <xref ref-type="table" rid="T1">Table 1</xref>).</p>
            <table-wrap id="T1" orientation="portrait" position="float">
                <label>Table 1. </label>
                <caption>
                    <title>Baseline characteristics of patients.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="2" rowspan="1" valign="top"/>
                            <th align="left" colspan="1" rowspan="1" valign="top">Number of participants (n)</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Percent (%)</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="2" valign="top">Gender</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Female</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">111</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">49.8</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Male</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">112</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">50.2</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Age</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">25 and under</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">69</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">31.1</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">26-35</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">71</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">32.0</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">36 and above</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">82</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">36.9</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="2" valign="top">Working status</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">No</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">85</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">38.1</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Yes</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">138</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">61.9</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">BMI</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Normal</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">163</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">73.1</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Overweight</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">52</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">23.3</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Obese</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">8</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">3.6</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="2" valign="top">Eating disorder in the family</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">No</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">196</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">87.9</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Yes</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">27</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">12.1</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="2" valign="top">Implant history</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">No</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">215</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">96.4</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Yes</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">8</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">3.6</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="2" valign="top">Oral and maxillofacial surgery history</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">No</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">174</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">78.0</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Yes</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">49</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">22.0</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="2" valign="top">Dentist fear</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">No</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">179</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">80.3</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Yes</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">44</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">19.7</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="2" valign="top">Regular dental care</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">No</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">37</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">16.6</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Yes</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">186</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">83.4</td>
                        </tr>
                    </tbody>
                </table>
            </table-wrap>
            <p>Difference analysis results showed that extroversion and neuroticism levels of patients were significantly higher after implant (p&lt;0.05). Pain, eating disorder and other personality type differences between before and after implant were statistically insignificant (p&gt;0.05) (
                <xref ref-type="table" rid="T2">Table 2</xref>).</p>
            <table-wrap id="T2" orientation="portrait" position="float">
                <label>Table 2. </label>
                <caption>
                    <title>Pain, eating disorder and personality types of patients and differences before and after implant.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1" valign="top"/>
                            <th align="left" colspan="1" rowspan="1" valign="top">Before implant</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">After implant</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">p value
                                <sup>a</sup>
                            </th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Pain level</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">3.09&#x00b1;2.90</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">2.97&#x00b1;2.78</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.551</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Eating disorder</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">10.26&#x00b1;4.34</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">10.13&#x00b1;4.91</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.450</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Extroversion</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">8.41&#x00b1;2.66</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">
                                <bold>8.97&#x00b1;2.20</bold>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">
                                <bold>0.017</bold>
                            </td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Agreeableness</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">8.72&#x00b1;2.59</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">9.01&#x00b1;2.10</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.191</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Self-control</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">8.33&#x00b1;2.62</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">8.10&#x00b1;3.01</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.294</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Neuroticism</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">7.54&#x00b1;3.14</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">
                                <bold>8.29&#x00b1;2.78</bold>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">
                                <bold>0.008</bold>
                            </td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Openness to experience</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">8.87&#x00b1;2.09</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">8.78&#x00b1;2.16</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.672</td>
                        </tr>
                    </tbody>
                </table>
                <table-wrap-foot>
                    <fn-group content-type="footnotes">
                        <fn id="tfn1">
                            <label>
                                <sup>a</sup>
                            </label>
                            <p>Wilcoxon Signed Rank Test.</p>
                        </fn>
                    </fn-group>
                </table-wrap-foot>
            </table-wrap>
            <p>Before implant, pain level was positively correlated with eating disorder (r=0.190; p&lt;0.01) and negatively correlated with self-control (r=-0.169; p&lt;0.01). After implant, pain level was negatively correlated with neuroticism (r=-0.140; p&lt;0.05) and openness to experience (r=-0.136; p&lt;0.05) (
                <xref ref-type="table" rid="T3">Table 3</xref>).</p>
            <table-wrap id="T3" orientation="portrait" position="float">
                <label>Table 3. </label>
                <caption>
                    <title>Spearman&#x2019;s rho correlation between pain, eating disorder and personality types before and after implant.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1" valign="top"/>
                            <th align="left" colspan="1" rowspan="1" valign="top">Pain level</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Eating disorder</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">
                                <bold>
                                    <italic toggle="yes">Before implant</italic>
                                </bold>
                            </td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Eating disorder/Pain level</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.190
                                <xref ref-type="table-fn" rid="tfn3">**</xref>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.190
                                <xref ref-type="table-fn" rid="tfn3">**</xref>
                            </td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Extroversion</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">-0.008</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">-0.187
                                <xref ref-type="table-fn" rid="tfn3">**</xref>
                            </td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Agreeableness</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">-0.051</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">-0.029</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Self-control</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">-0.169
                                <xref ref-type="table-fn" rid="tfn3">**</xref>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">-0.178
                                <xref ref-type="table-fn" rid="tfn3">**</xref>
                            </td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Neuroticism</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">-0.085</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">-0.059</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Openness to experience</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.035</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.064</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">
                                <bold>
                                    <italic toggle="yes">After implant</italic>
                                </bold>
                            </td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Eating disorder/Pain level</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.125</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.125</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Extroversion</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.023</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">-0.237
                                <xref ref-type="table-fn" rid="tfn3">**</xref>
                            </td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Agreeableness</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">-0.038</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">-0.042</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Self-control</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.065</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">-0.151
                                <xref ref-type="table-fn" rid="tfn2">*</xref>
                            </td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Neuroticism</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">-0.140
                                <xref ref-type="table-fn" rid="tfn2">*</xref>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">-0.187
                                <xref ref-type="table-fn" rid="tfn3">**</xref>
                            </td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Openness to experience</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">-0.136
                                <xref ref-type="table-fn" rid="tfn2">*</xref>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.019</td>
                        </tr>
                    </tbody>
                </table>
                <table-wrap-foot>
                    <fn-group content-type="footnotes">
                        <fn id="tfn2">
                            <label>*</label>
                            <p>p&lt;0.05.</p>
                        </fn>
                        <fn id="tfn3">
                            <label>**</label>
                            <p>p&lt;0.01.</p>
                        </fn>
                    </fn-group>
                </table-wrap-foot>
            </table-wrap>
            <p>Before implant, eating disorder level was positively correlated with pain (r=0.190; p&lt;0.01); negatively correlated with extroversion (r=-0.187; p&lt;0.01) and self-control (r=-0.178; p&lt;0.01). After implant, eating disorder level was negatively correlated with extroversion (r=-0.237; p&lt;0.01), self-control (r=-0.151; p&lt;0.05) and neuroticism (r=-0.187; p&lt;0.01) (
                <xref ref-type="table" rid="T3">Table 3</xref>).</p>
            <p>Generalized Linear (Logit) Model analysis results showed that only extroversion personality type level had significant and negative effect on eating disorder after implant at multivariate level (B=-0.43; p&lt;0.01) (
                <xref ref-type="table" rid="T4">Table 4</xref>). Before Generalized Linear (Logit) Model, correlation between demographic and baseline characteristics of patients were also analyzed. Since their correlations were insignificant (p&lt;0.05), they were not included in the regression model.</p>
            <table-wrap id="T4" orientation="portrait" position="float">
                <label>Table 4. </label>
                <caption>
                    <title>Generalized Linear (Logit) Model for significant factors affecting eating disorder after implant.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="2" valign="top">Parameter</th>
                            <th align="left" colspan="1" rowspan="2" valign="top">B</th>
                            <th align="left" colspan="1" rowspan="2" valign="top">Std. Error</th>
                            <th align="left" colspan="2" rowspan="1" valign="top">95% Wald Confidence Interval</th>
                            <th align="left" colspan="3" rowspan="1" valign="top">Hypothesis Test</th>
                        </tr>
                        <tr>
                            <th align="left" colspan="1" rowspan="1" valign="top">Lower</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Upper</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Wald Chi-Square</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">df</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">p value</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">(Intercept)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">17.17</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1.68</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">13.87</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">20.46</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">104.51</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.000</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Extroversion</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.43</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.15</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.71</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.14</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">8.44</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.004</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Self-control</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.19</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.11</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.40</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.02</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.25</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.071</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Neuroticism</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.20</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.11</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.42</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.03</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.00</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.083</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">(Scale)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">22.18</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.10</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18.42</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">26.70</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                    </tbody>
                </table>
            </table-wrap>
        </sec>
        <sec id="sec12" sec-type="discussion">
            <title>Discussion</title>
            <p>In this study, the relationship between the personality types of individuals before and after implantation with pain and eating disorders was examined. For this purpose, the effects of personality types on eating disorders were analyzed before and after implantation on 223 patients, and both unidimensional and multidimensional analyzes of factors that may affect eating disorders were performed.</p>
            <p>Although implant applications are very important applications for oral and dental health today, clinical studies and research generally focus on concrete properties of implants such as biological properties, osseointegration, and permanence.
                <sup>
                    <xref ref-type="bibr" rid="ref14">14</xref>
                </sup>
                <sup>&#x2013;</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref18">18</xref>
                </sup> Studies on the relationship between eating disorders and personality structures of individuals after dental implants are quite limited. However, the relationship between oral and dental health and eating disorders has been the subject of many studies, and it can be stated that there is both a physical and psychological relationship between oral health and eating disorders. Therefore, it can be argued that personality types that affect the psychological structures of individuals are also effective on eating disorders and pain perception.</p>
            <p>In studies on oral and dental health and eating disorders in the literature, eating disorders are also observed in people with impaired oral health.
                <sup>
                    <xref ref-type="bibr" rid="ref19">19</xref>
                </sup>
                <sup>&#x2013;</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref22">22</xref>
                </sup> Patterson Norrie 
                <italic toggle="yes">et al</italic>.
                <sup>
                    <xref ref-type="bibr" rid="ref5">5</xref>
                </sup> reported in their study that individuals with oral health problems have eating disorders. In another study, Brandt 
                <italic toggle="yes">et al</italic>.
                <sup>
                    <xref ref-type="bibr" rid="ref21">21</xref>
                </sup> reported that the relationship between individuals&#x2019; oral health and eating disorders was significant in terms of care, and those with eating disorders were obsessed with oral health. In our study, the differences between pre- and post-implant pain levels and eating disorder levels were not statistically significant. This may be related to the fact that implant applications are now much more effective, in a shorter time, and that patients have a high level of trust in both the surgeon and the institution. Thanks to the physician and institution informing the patient at a sufficient level, the patient is informed about what they will live and as a result, he has less anxiety. This situation positively affects the mental well-being of the patient. Therefore, an increase in the level of eating disorder and pain may not have been observed after the implant. The fact that the study was single-centered may also have an effect on this result. Research findings can be further deepened with larger samples and multicenter studies.</p>
            <p>Studies on personality types and the characters of individuals report that the character tends to remain unchanged in general. However, possible changes require trauma, unusual events, or prolonged exposure. On the other hand, personality types, on the other hand, change more easily than the character, while they show the attitude that people take according to the event or situation.
                <sup>
                    <xref ref-type="bibr" rid="ref23">23</xref>
                </sup>
                <sup>&#x2013;</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref25">25</xref>
                </sup> In our study, a statistically significant increase was observed in extraversion and neuroticism levels in patients compared to pre-implantation. However, the difference between other personality types before and after implant was not statistically significant. It is possible to state that the symptomatic personality type scale has an effect on this difference. The Five Factor Personality Scale shows the degrees of these personality types, not the exact personality types of individuals. For this reason, it can be stated that post-implantation individuals do not turn into extroverted and neurotic individuals, only their weight on these personality types increases. Another possible reason for this result is that implant application is a traumatizing phenomenon to some extent. Although today, implant applications are very successful and with minimum pain, as a result, an invasive procedure is performed on individuals with implants. This situation can be partially evaluated as trauma.</p>
            <p>In our study, the meaning and positive effect of pain on pre-implant eating disorder is an expected situation that shows the reliability of the data of the research scales. In addition, extroversion and self-control before implant have a decreasing effect on eating disorders. This situation is also significant in terms of its relationship with mental well-being, especially in terms of self-control. The fact that extroverts are more social and social individuals have a higher level of mental well-being supports this situation.</p>
            <p>After the implant, extraversion, self-control and neuroticism have a decreasing effect on eating disorder. However, this effect, which is significant in one dimension, gives a result in which only the level of extraversion is significant in multivariate analysis. In other words, when all personality types, pain and personal characteristics are evaluated together, eating disorders are less common in extroverted individuals. This finding shows that as the level of extraversion of individuals increases, the level of post-implant eating disorder development will be lower, and the reverse is also true. In other words, more introverted individuals will be more likely to have an eating disorder.</p>
            <p>The most important limitation of the study is that it was conducted as a single center and the demographic characteristics of the patients were close to each other. More comprehensive findings on the effect of implant application, personality types and pain on eating disorders can be obtained in multicenter studies. Most importantly, since the level of informing patients will differ in different institutions, it may be possible to see the effect of psychological effects and personality structures more clearly. However, the process of getting permission from different institutions in the field of health and collecting data includes very serious and tiring processes.</p>
            <p>Another important limitation of the study is the lack of more original and specific measurement tools for the field of oral and dental health. Today, although scales such as fear of the dentist, trust in the doctor, and fear of tooth extraction are being developed, these are the scales that are mostly associated with children&#x2019;s fear of the dentist. There is a need for more comprehensive and site-specific scales for adults.</p>
            <p>The most important contribution of the research to the literature is that it is a pioneering study in terms of its subject. Studies and studies in the literature mostly focus on biological data related to implants. This research proposes to focus on psychological factors, which are also important in the field of dental implants. In this respect, the research can be shown among the pioneering studies in the field.</p>
            <p>Another contribution of the research to the literature is that, with a simple session to be given to extroverted and introverted individuals after the implant, it may be possible to pre-treat or prevent eating disorders that may develop in these individuals and may be much more difficult to compensate in the future. In this respect, the research gives useful results in terms of clinical applications and original results in terms of preventive medicine.</p>
            <p>According to the results of the research, it is possible to prevent eating disorders that are likely to develop after dental implants by increasing the degree of extraversion of individuals or by giving short and effective sessions to introverted individuals. Although it is not absolute that every individual with low extraversion will develop an eating disorder, eating disorders can be prevented it, even infrequently, with partially cost-effective eating disorder informative sessions in a large population. This situation can make a significant contribution both in terms of individuals&#x2019; quality of life, public resources and public health, and oral and dental health.</p>
        </sec>
    </body>
    <back>
        <sec id="sec15" sec-type="data-availability">
            <title>Data availability</title>
            <sec id="sec16">
                <title>Underlying data</title>
                <p>Open Science Framework: eating disorders and pain levels before and after implantation with personality type. 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.17605/OSF.IO/BSV28">https://doi.org/10.17605/OSF.IO/BSV28</ext-link>.
                    <sup>

                        <xref ref-type="bibr" rid="ref26">26</xref>
</sup>
                </p>
                <p>Data are available under the terms of the 
                    <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International license</ext-link> (CC-BY 4.0).</p>
            </sec>
        </sec>
        <ack>
            <title>Acknowledgements</title>
            <p>Thanks Kadir YILMAZ for his valuable statistical support.</p>
        </ack>
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                    <data-title>eating disorders and pain levels before and after implantation with personality type.</data-title>[Dataset].<year>2023, October 4</year>.
                    <pub-id pub-id-type="doi">10.17605/OSF.IO/BSV28</pub-id>
                </mixed-citation>
            </ref>
        </ref-list>
    </back>
    <sub-article article-type="reviewer-report" id="report252849">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.155173.r252849</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Tamam</surname>
                        <given-names>Lut</given-names>
                    </name>
                    <xref ref-type="aff" rid="r252849a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-9750-7531</uri>
                </contrib>
                <aff id="r252849a1">
                    <label>1</label>Department of Psychiatry, &#x00c7;ukurova University School of Medicine, Adana, Turkey</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>9</day>
                <month>3</month>
                <year>2024</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2024 Tamam L</copyright-statement>
                <copyright-year>2024</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport252849" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.141705.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>The study, conducted on 223 dental implant patients, examines the relationships between personality types, eating disorders, and pain perception levels before and after implantation. The findings reveal an increase in extroversion and neuroticism after implantation and a significant negative correlation between extroversion and post-implant eating disorders. The study suggests that dental implantation may impact personality types and emphasizes the importance of psychological factors in oral health research. It proposes interventions, such as sessions for extroverted and introverted individuals, to potentially prevent post-implant eating disorders and contribute to overall public health. This original study needs significant revisions in many parts of the article. My comments are as follows; 
                <list list-type="order">
                    <list-item>
                        <p>In the introduction, the study proposes a link between oral and dental health, eating disorders, and personality types; however, it falls short in clearly defining the research gap and specific study objectives until later in the text. To enhance clarity, the authors should provide a more focused and explicit statement regarding the research goals and the unique contribution of the study to existing literature.</p>
                    </list-item>
                    <list-item>
                        <p>The concept of personality types or structures introduced in the introduction requires clarification, including their relevance to the study aims. The authors should provide a clear definition and explanation to ensure a better understanding of these terms in the context of their research.</p>
                    </list-item>
                    <list-item>
                        <p>While the authors state that sample size calculation was deemed unsuitable due to the pioneering nature of the study, a post-hoc power analysis could have been conducted to ensure statistical robustness. This information should be added to the relevant section. Additionally, the study procedure section needs more details on participant recruitment and should address potential biases introduced by the voluntary participation method.</p>
                    </list-item>
                    <list-item>
                        <p>The inclusion criteria lack explicit discussion on their selection and relevance to the research objectives. The authors should provide details on how these criteria, such as the absence of chronic disorders or psychiatric diseases, were evaluated or confirmed. The statement in the procedure that all cases were included "without any preliminary evaluation" contradicts the inclusion and exclusion criteria.</p>
                    </list-item>
                    <list-item>
                        <p>The validity and reliability of the measures used in the study are inadequately discussed. Relying mainly on Cronbach Alpha values is insufficient to assess the overall psychometric properties of the scales. The authors should provide information on the psychometric properties of both original and adapted measures, including citations for the original scales.</p>
                    </list-item>
                    <list-item>
                        <p>The statistical methods section lacks a detailed rationale for the chosen methods, particularly for the composition of the model and the inclusion of variables in the Generalized Linear Model (Logit). A more comprehensive explanation of the chosen statistical methods is necessary.</p>
                    </list-item>
                    <list-item>
                        <p>The discussion suggests personality changes after dental implantation, specifically increased extroversion and neuroticism, without sufficient evidence or references. The authors should soften their statements and explore potential mechanisms behind the observed changes to strengthen the discussion.</p>
                    </list-item>
                    <list-item>
                        <p>The discussion disproportionately focuses on extraversion as the significant personality factor affecting post-implant eating disorders, neglecting the exploration of other personality factors. A more balanced discussion considering the study's limitations is essential.</p>
                    </list-item>
                    <list-item>
                        <p>The discussion makes broad generalizations, such as suggesting interventions for extroverted and introverted individuals to prevent eating disorders after dental implants. However, these statements lack validation and overlook potential individual variations and the complexity of psychological factors. The authors should revise these sections.</p>
                    </list-item>
                </list>
            </p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Yes</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Partly</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Partly</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Partly</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Partly</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Reviewer Expertise:</p>
            <p>psychiatry, psychopharmacology</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
    </sub-article>
</article>
