<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN" "http://jats.nlm.nih.gov/publishing/1.2/JATS-journalpublishing1.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="other" dtd-version="1.2" xml:lang="en">
    <front>
        <journal-meta>
            <journal-id journal-id-type="pmc">F1000Research</journal-id>
            <journal-title-group>
                <journal-title>F1000Research</journal-title>
            </journal-title-group>
            <issn pub-type="epub">2046-1402</issn>
            <publisher>
                <publisher-name>F1000 Research Limited</publisher-name>
                <publisher-loc>London, UK</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="doi">10.12688/f1000research.135336.1</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Study Protocol</subject>
                </subj-group>
                <subj-group>
                    <subject>Articles</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Assessment and comparison of age-related three-dimensional variation in the anterior loop of the inferior alveolar nerve for pre-surgical planning</article-title>
                <fn-group content-type="pub-status">
                    <fn>
                        <p>[version 1; peer review: 1 approved with reservations]</p>
                    </fn>
                </fn-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author" corresp="yes">
                    <name>
                        <surname>Waghadkar</surname>
                        <given-names>Abhilasha Ramesh</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-5085-5387</uri>
                    <xref ref-type="corresp" rid="c1">a</xref>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Lohe</surname>
                        <given-names>Vidya K</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <aff id="a1">
                    <label>1</label>Oral Medicine and Radiology, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, 442001, India</aff>
            </contrib-group>
            <author-notes>
                <corresp id="c1">
                    <label>a</label>
                    <email xlink:href="mailto:abhilashawaghadkar2@gmail.com">abhilashawaghadkar2@gmail.com</email>
                </corresp>
                <fn fn-type="conflict">
                    <p>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>20</day>
                <month>10</month>
                <year>2023</year>
            </pub-date>
            <pub-date pub-type="collection">
                <year>2023</year>
            </pub-date>
            <volume>12</volume>
            <elocation-id>1386</elocation-id>
            <history>
                <date date-type="accepted">
                    <day>5</day>
                    <month>9</month>
                    <year>2023</year>
                </date>
            </history>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2023 Waghadkar AR and Lohe VK</copyright-statement>
                <copyright-year>2023</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <self-uri content-type="pdf" xlink:href="https://f1000research.com/articles/12-1386/pdf"/>
            <abstract>
                <p>
                    <bold>Background:</bold> The mental foramen (M.F.) is crossed anteriorly by the mental neurovascular bundle, then does a U-turn to leave M.F. The anterior loop is a section of the inferior alveolar nerve. Prior to deciding how to operate on the anterior mandible, it is essential to take this anatomic variation into account.</p>
                <p>
                    <bold>Methods:</bold> This study will be carried out by studying 70 cone-beam computed tomography scans. The anterior loop will be measured using the PLANMECA proMax Cone Beam Computed Tomography (CBCT) measuring tool. Its measurement specifications include a cylinder-shaped field of view with a voxel size of 300, a voltage in tubes of 90 kV, 6.3 mA tube current, and a 12-second exposure period. The field of view will be the same for all scans to standardize the criteria for selecting images from scans.</p>
                <p>
                    <bold>Conclusions:</bold> Compared to multi-slice computed tomography, C.B.C.T. has a number of advantages, including the ability to analyze craniofacial features in three dimensions without distortion or overlapping images. Furthermore, C.B.C.T. is considered the gold standard for assessing bone tissue. Correctly identifying and protecting neurovascular bundles is crucial to preventing sensorineural damage in the interforaminal area. This is because there are significant individual anatomical differences present to varying degrees. Therefore, the present study is undertaken with the objectives of recognizing the Antecedent Inferior Alveolar Nerve loop, evaluating the dimensions of the A.L. for pre-surgical planning, and comparing the age-related three-dimensional variations in A.L. of the Inferior Alveolar nerve.</p>
            </abstract>
            <kwd-group kwd-group-type="author">
                <kwd>Cone-beam computed tomography</kwd>
                <kwd>mandibular nerve</kwd>
                <kwd>mental foramen.</kwd>
            </kwd-group>
            <funding-group>
                <funding-statement>The author(s) declared that no grants were involved in supporting this work.</funding-statement>
            </funding-group>
        </article-meta>
    </front>
    <body>
        <sec id="sec1" sec-type="intro">
            <title>Introduction</title>
            <p>The mental neurovascular bundle crosses the inferior alveolar nerve&#x2019;s anterior loop, located before the Mental Foramen (M.F) then turns around to exit the M. F. This anatomic variance must be taken into consideration when surgical operations on the anterior mandible are planned. Osteotomy, bone harvesting, and dental implant placement are all considered safe elective procedures.
                <sup>
                    <xref ref-type="bibr" rid="ref1">1</xref>
                </sup>
            </p>
            <p>The human face has high innervations. The fifth cranial nerve, the Trigeminal nerve, regulates face sensibility. The trigeminal ganglion is located in the Middle Cranial Fossa of the Sella Turcica, and is the origin of the trigeminal nerve&#x2019;s sensory branch. The Ophthalmic, Maxillary, and Mandibular branches, in turn, innervate the top, middle, and lower three-quarters of the head. The Mandibular nerveis the 3
                <sup>rd</sup> branch of the trigeminal nerve. Which enters the mandible via the mandibular foramen.
                <sup>
                    <xref ref-type="bibr" rid="ref1">1</xref>
                </sup> The Inferior Alveolar Nerve is the nerve that passes Via use of the M.F. The inferior alveolar nerve&#x2019;s terminal portion can rarely cross through the mental foramen&#x2019;s lower border and continue as an intra-osseous anterior loop. Despite being a benign anatomical variation, it needs to be accurately identified in order to plan surgery that involves the insertion of implants as well as anterior mandibular operations such as genioplasty, mandibular premolar root extraction, chin bone harvesting, and surgical rehabilitation after mandibular injury.
                <sup>
                    <xref ref-type="bibr" rid="ref2">2</xref>
                </sup>
            </p>
            <p>The standard of therapy for edentulous mandibles is to insert dental implants in the anterior mandible. There were anatomical hazards in the anterior mandible, despite the surgery being usually viewed as safe.
                <sup>
                    <xref ref-type="bibr" rid="ref3">3</xref>
                </sup> With the advent of endosseus, replacing lost teeth with dental implants has become a very predictable medical option. The gold standard of treatment for edentulous mandibles was the installation of implants in the front mandible. Although the procedure is generally viewed as safe, there are some anatomical difficulties in using the front mandible.
                <sup>
                    <xref ref-type="bibr" rid="ref5">5</xref>
                </sup> The most significant anatomical risk will be the potential for the IAN anterior loop, which emerges through the M.F.If the I.A.N. is not detected before surgery, there may be iatrogenic nerve harm. An injury to the A.L. would lead to damage to the mental nerves. As a result, the mental nerve can become anesthetized, experience paraesthesia, or encounter dysesthesia.
                <sup>
                    <xref ref-type="bibr" rid="ref6">6</xref>
                </sup> The labiodental region and the gingiva up to the second premolar on the jaw are both detectable by the mental nerve. It could be tricky to carry out regular activities like eating, speaking, and even brushing your teeth if there is a changed sensation in this area.
                <sup>
                    <xref ref-type="bibr" rid="ref6">6</xref>
                </sup>
            </p>
            <p>C.B.C.T. should provide a number of advantages over multi-slice computed tomography, including the capacity to assess craniofacial traits in three dimensions (3D) without distortion or overlapping pictures.
                <sup>
                    <xref ref-type="bibr" rid="ref7">7</xref>
                </sup> Preventing sensorineural injury in the interforaminal region requires accurate neurovascular bundle identification and protection.</p>
            <sec id="sec2">
                <title>Aim</title>
                <p>The aim of this study is to assess and compare age-related three-dimensional variation in the anterior loop of the inferior alveolar nerve for pre-surgical planning.</p>
            </sec>
            <sec id="sec3">
                <title>Objective</title>
                <p>
                    <list list-type="order">
                        <list-item>
                            <label>1.</label>
                            <p>To identify the nerve&#x2019;s anterior loop is the lower alveolar.</p>
                        </list-item>
                        <list-item>
                            <label>2.</label>
                            <p>To analyse the size of the A.L. of I.A.N. for pre-surgical planning.</p>
                        </list-item>
                        <list-item>
                            <label>3.</label>
                            <p>To compare the age-wise three-dimensional variations in A.L. of inferior alveolar.</p>
                        </list-item>
                    </list>
                </p>
            </sec>
        </sec>
        <sec id="sec4" sec-type="methods">
            <title>Methods</title>
            <sec id="sec5">
                <title>Ethical considerations</title>
                <p>The study proposal was approved by &#x201c;Institutional Ethics Committee&#x201d; of DMIMSDU, Sawangi (meghe), Wardhawith Ref. No. DMIHER (DU)/IEC/2023/855 on 31/03/2023.</p>
            </sec>
            <sec id="sec6">
                <title>Materials</title>
                <p>Patients will be selected as per the inclusions and exclusion criteria. This study will be done using Cone Beam Computed Tomography. The study will be conducted at Sharad Pawar Dental College, Sawangi (Meghe), Wardha, in the Dept. of Oral Medicine and Radiology.</p>
            </sec>
            <sec id="sec7">
                <title>Equipment</title>
                <p>PLANMECA pro-Max C.B.C.T. machine with Romexis viewer.</p>
            </sec>
            <sec id="sec8">
                <title>Inclusion criteria</title>
                <p>
                    <list list-type="order">
                        <list-item>
                            <label>1.</label>
                            <p>Patients between the ages of 16 and 65 years.</p>
                        </list-item>
                        <list-item>
                            <label>2.</label>
                            <p>The CBCT scan must show teeth at the mandibular frontal region on both sides, up to 2-3 cm from the foramen mental.</p>
                        </list-item>
                        <list-item>
                            <label>3.</label>
                            <p>The mandibular canal and mental foramen siteswhich cannot be altered by pathological changes.</p>
                        </list-item>
                        <list-item>
                            <label>4.</label>
                            <p>There is no sign of any surgery or trauma that would have changed the mandibular canal&#x2019;s or the mental foramen&#x2019;s position.</p>
                        </list-item>
                    </list>
                </p>
            </sec>
            <sec id="sec9">
                <title>Exclusive criteria</title>
                <p>
                    <list list-type="order">
                        <list-item>
                            <label>1.</label>
                            <p>Systemic illness (DiabeticMallitus, Hypertentionetc) presence.</p>
                        </list-item>
                        <list-item>
                            <label>2.</label>
                            <p>Individuals receiving radiotherapy.</p>
                        </list-item>
                        <list-item>
                            <label>3.</label>
                            <p>Implants or mental artifacts in the area of the foramen.</p>
                        </list-item>
                        <list-item>
                            <label>4.</label>
                            <p>Abnormalities during teeth and bone development are present.</p>
                        </list-item>
                    </list>
                </p>
            </sec>
            <sec id="sec10">
                <title>Procedure</title>
                <p>Patients reporting to the Department of Oral Medicine and Radiology will be approached to take part. Those who are willing to participate in the study and give written informed consent will be included in the study (see 
                    <italic toggle="yes">Extended data</italic> for the sample consent form
                    <sup>
                        <xref ref-type="bibr" rid="ref9">9</xref>
                    </sup>).</p>
                <p>After satisfying the inclusion and exclusion criteria (via medical records), patients will be taken for C.B.C.T. imaging. The three-dimensional PLANMECA proMax C.B.C.T. equipment with an exposure period of 11.30 s, a tube voltage of 90 kV, a current in a tube of 5 mA, and a cylindrical F.O.V. measuring 17mm 13mm with a voxel size of 300 will be used to acquire the C.B.C.T. pictures. To standardize the image selection criterion, the F.O.V. will be the same throughout all scans. Each picture should be af 90&#x03bc;m, and a single 360-degree scan will be used. All the scans will be taken with the subject&#x2019;s head in an upright position and the patient will be instructed to make molars to molars contact and to breathe from their nose.</p>
            </sec>
            <sec id="sec11">
                <title>Data analysis</title>
                <p>The occlusal plane will be horizontally positioned to the scan plane. The cantered plane will be the midsagittal plane. The planes on the CBCT pictures&#x2019; three axes (X,Y,Z) will be analyzed in order. All of the images&#x2019; contrast and brightness will be kept constant for consistency during image analysis. All images will be evaluated under the best viewing conditions using picture viewing software PLANMECA pro-Max.Each volume&#x2019;s axial slice will be rebuilt on the specified axial slice and parallel to the mandible&#x2019;s lower edge. The most anterior section of the IAN and the MF most anterior segment will be marked &amp; length will be measured using PLANMECA pro-Max software.</p>
            </sec>
            <sec id="sec12">
                <title>Sample size calculation</title>
                <p>
                    <bold>Cochian Formula for Sample Size:</bold>
                    <disp-formula id="e1">
                        <mml:math display="block">
                            <mml:mi>n</mml:mi>
                            <mml:mo>=</mml:mo>
                            <mml:mfrac>
                                <mml:mrow>
                                    <mml:mi>Z&#x03b1;l</mml:mi>
                                    <mml:mn>2</mml:mn>
                                    <mml:mo>.</mml:mo>
                                    <mml:mi mathvariant="normal">P</mml:mi>
                                    <mml:mo>.</mml:mo>
                                    <mml:mfenced close=")" open="(">
                                        <mml:mrow>
                                            <mml:mn>1</mml:mn>
                                            <mml:mo>&#x2212;</mml:mo>
                                            <mml:mi mathvariant="normal">P</mml:mi>
                                        </mml:mrow>
                                    </mml:mfenced>
                                </mml:mrow>
                                <mml:msup>
                                    <mml:mi>d</mml:mi>
                                    <mml:mn>2</mml:mn>
                                </mml:msup>
                            </mml:mfrac>
                        </mml:math>
                    </disp-formula>
                </p>
                <p>Where;</p>
                <p>Z&#x03b1;l2 is the level of significance at 5%, i.e. 95% .confidenece interval = 1.96</p>
                <p>P = prevalence of inferior alveolar nerve anterior loop = 22% = 0.22</p>
                <p>d = desired error of margin = 10% = 0.10
                    <disp-formula id="e2">
                        <mml:math display="block">
                            <mml:mtable displaystyle="true">
                                <mml:mtr>
                                    <mml:mtd>
                                        <mml:mi mathvariant="normal">n</mml:mi>
                                        <mml:mo>=</mml:mo>
                                        <mml:msup>
                                            <mml:mn>1.96</mml:mn>
                                            <mml:mn>2</mml:mn>
                                        </mml:msup>
                                        <mml:mo>&#x00d7;</mml:mo>
                                        <mml:mn>0.22</mml:mn>
                                        <mml:mo>&#x00d7;</mml:mo>
                                        <mml:mfenced close=")" open="(">
                                            <mml:mrow>
                                                <mml:mn>1</mml:mn>
                                                <mml:mo>&#x2212;</mml:mo>
                                                <mml:mn>0.22</mml:mn>
                                            </mml:mrow>
                                        </mml:mfenced>
                                        <mml:mo>/</mml:mo>
                                        <mml:msup>
                                            <mml:mn>0.10</mml:mn>
                                            <mml:mn>2</mml:mn>
                                        </mml:msup>
                                    </mml:mtd>
                                </mml:mtr>
                                <mml:mtr>
                                    <mml:mtd>
                                        <mml:mo>=</mml:mo>
                                        <mml:mn>65.92</mml:mn>
                                    </mml:mtd>
                                </mml:mtr>
                                <mml:mtr>
                                    <mml:mtd>
                                        <mml:mo>=</mml:mo>
                                        <mml:mn>70</mml:mn>
                                    </mml:mtd>
                                </mml:mtr>
                            </mml:mtable>
                        </mml:math>
                    </disp-formula>
                </p>
                <p>Study Reference:
                    <sup>
                        <xref ref-type="bibr" rid="ref8">8</xref>
                    </sup>
                </p>
            </sec>
            <sec id="sec13">
                <title>Dissemination</title>
                <p>This study protocol will be published in a PubMed, Web of Science, and Scopus Indexed Journal.</p>
            </sec>
            <sec id="sec14">
                <title>Study status</title>
                <p>Not Yet Started.</p>
            </sec>
        </sec>
        <sec id="sec15" sec-type="discussion">
            <title>Discussion</title>
            <sec id="sec16">
                <title>Key Result</title>
                <p>There are positions of the MC laterally in women, especially at the level of the premolars, that have been discovered to be significantly and clinically relevant correlated as observed on CBCT.</p>
            </sec>
            <sec id="sec17">
                <title>Interpretation</title>
                <p>
                    <bold>In research by Baratollah Shaban 
                        <italic toggle="yes">et al</italic>. 2017</bold>
                    <sup>
                        <xref ref-type="bibr" rid="ref2">2</xref>
                    </sup> 71 patients&#x2019; CBCT scans were used. There are three main anatomical variations of the IAN anterior loop. Type I: The incisive branch thickness is comparable to that of the main branch, and the anatomy is Y-shaped.</p>
                <p>
                    <bold>Edudara Helena Leandro do Nascimento 
                        <italic toggle="yes">et al</italic>. 2016</bold>
                    <sup>
                        <xref ref-type="bibr" rid="ref3">3</xref>
                    </sup> employed CBCT on 250 patients; it was possible to determine the frequency and severity of anterior loop in a Brazilian population. Gender, age, and mandibular side were taken into consideration while contrasting the anterior loop&#x2019;s length.</p>
                <p>
                    <bold>Juan Muileno Lorenzo 
                        <italic toggle="yes">et al</italic>. 2015</bold>
                    <sup>
                        <xref ref-type="bibr" rid="ref4">4</xref>
                    </sup> compared the MF and AMF visualization capabilities of CBCT and panoramic radiograph and used CBCT to examine the supplementary mental foramen&#x2019;s existence and the anatomic characteristics of the MF. The sample for the study included CBCT and PAN tests were performed on 357 individuals. The average AMF area in the study was between 1.5 and 2 mm.</p>
                <p>
                    <bold>Fereidoumparnia 
                        <italic toggle="yes">et al</italic>. 2012</bold>
                    <sup>
                        <xref ref-type="bibr" rid="ref5">5</xref>
                    </sup> determined that it is risky to suggest any particular medial distance from the mental foramen after conducting a study on 96 patients using CBCT to evaluate the Anatomical landmarks in the mandibular: their appearance, visibility, placement, and course inter-foraminal region. The diameter of the canal and foramen should be evaluated separately for each person in order to choose the appropriate location.</p>
            </sec>
        </sec>
    </body>
    <back>
        <sec id="sec20" sec-type="data-availability">
            <title>Data availability</title>
            <sec id="sec21">
                <title>Underlying data</title>
                <p>No data are associated with this article.</p>
            </sec>
            <sec id="sec22">
                <title>Extended data</title>
                <p>Zenodo: Assessment and comparison of age-related three-dimensional variation in the anterior loop of the inferior alveolar nerve for pre-surgical planning. 
                    <ext-link ext-link-type="uri" xlink:href="https://zenodo.org/record/8272121">https://zenodo.org/record/8272121</ext-link>.
                    <sup>

                        <xref ref-type="bibr" rid="ref9">9</xref>
</sup>
                </p>
                <p>This project contains the following extended data:
                    <list list-type="bullet">
                        <list-item>
                            <label>-</label>
                            <p>Consent form.docx</p>
                        </list-item>
                    </list>
                </p>
                <p>Data are available under the terms of the 
                    <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International license</ext-link> (CC-BY 4.0).</p>
            </sec>
        </sec>
        <ack>
            <title>Acknowledgments</title>
            <p>I acknowledge the help from my university, college, professors, department, statistician, and resources, which provided the necessary data and their inputs for this given clinical study.</p>
        </ack>
        <ref-list>
            <title>References</title>
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                        <italic toggle="yes">J. Indian Acad. Oral Med. Radiol.</italic>
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    </back>
    <sub-article article-type="reviewer-report" id="report241484">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.148450.r241484</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Hadidi</surname>
                        <given-names>Yasser Nabil El</given-names>
                    </name>
                    <xref ref-type="aff" rid="r241484a1">1</xref>
                    <role>Referee</role>
                </contrib>
                <aff id="r241484a1">
                    <label>1</label>Ain Shams University, Cairo, Egypt</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>4</day>
                <month>3</month>
                <year>2024</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2024 Hadidi YNE</copyright-statement>
                <copyright-year>2024</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport241484" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.135336.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>Dear author</p>
            <p> The current manuscript presents an interesting study.</p>
            <p> Pros</p>
            <p> Detail of changes with age regarding position of anterior looping based on&#x00a0;CBCT data.</p>
            <p> Cons</p>
            <p> No mention of previous similar studies.Introductions need more enriching by similar studies as ref [1]</p>
            <p> </p>
            <p> Minor comments</p>
            <p> The objective must be beneficial to dental surgeons and endodontists. For example, must carry a take a home message, recommendation or guidelines for implant placement in premolar area, apicectomy procedure in premolar area for example.&#x00a0;</p>
            <p> </p>
            <p> Major comment</p>
            <p> Please assess the data by two examiners and perform inter examiner reliability test to confirm the recorded data.</p>
            <p> Thanks for consideration!</p>
            <p>Is the study design appropriate for the research question?</p>
            <p>Yes</p>
            <p>Is the rationale for, and objectives of, the study clearly described?</p>
            <p>Yes</p>
            <p>Are sufficient details of the methods provided to allow replication by others?</p>
            <p>Yes</p>
            <p>Are the datasets clearly presented in a useable and accessible format?</p>
            <p>Yes</p>
            <p>Reviewer Expertise:</p>
            <p>oral and maxillofacial surgery</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
        <back>
            <ref-list>
                <title>References</title>
                <ref id="rep-ref-241484-1">
                    <label>1</label>
                    <mixed-citation publication-type="journal">
                        <person-group person-group-type="author"/>:
                        <article-title>Anatomical Analysis of Inferior Alveolar Nerve Relation to Mandibular Posterior Teeth Using Cone Beam Computed Tomography: A Retrospective Radiographic Analysis Study.</article-title>
                        <source>
                            <italic>J Maxillofac Oral Surg</italic>
                        </source>.<year>2024</year>;<volume>23</volume>(<issue>1</issue>) :
                        <elocation-id>10.1007/s12663-022-01792-5</elocation-id>
                        <fpage>7</fpage>-<lpage>13</lpage>
                        <pub-id pub-id-type="pmid">38312962</pub-id>
                        <pub-id pub-id-type="doi">10.1007/s12663-022-01792-5</pub-id>
                    </mixed-citation>
                </ref>
            </ref-list>
        </back>
        <sub-article article-type="response" id="comment12986-241484">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Waghadkar</surname>
                            <given-names>Dr. Abhilasha</given-names>
                        </name>
                        <aff>Oral Medicine and Radiology, Sharad Pawar Dental College, Wardha, Maharashtra, India</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>18</day>
                    <month>12</month>
                    <year>2024</year>
                </pub-date>
            </front-stub>
            <body>
                <p>Ok respected sir..</p>
            </body>
        </sub-article>
        <sub-article article-type="response" id="comment14375-241484">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Waghadkar</surname>
                            <given-names>Dr. Abhilasha</given-names>
                        </name>
                        <aff>Oral Medicine and Radiology, Sharad Pawar Dental College, Wardha, Maharashtra, India</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>18</day>
                    <month>8</month>
                    <year>2025</year>
                </pub-date>
            </front-stub>
            <body>
                <p>Respected sir,&#x00a0;</p>
                <p> In my research study I clearly mentioned about age related parameter and that reference article too..</p>
            </body>
        </sub-article>
    </sub-article>
</article>
