<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN" "http://jats.nlm.nih.gov/publishing/1.2/JATS-journalpublishing1.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="research-article" dtd-version="1.2" xml:lang="en">
    <front>
        <journal-meta>
            <journal-id journal-id-type="pmc">F1000Research</journal-id>
            <journal-title-group>
                <journal-title>F1000Research</journal-title>
            </journal-title-group>
            <issn pub-type="epub">2046-1402</issn>
            <publisher>
                <publisher-name>F1000 Research Limited</publisher-name>
                <publisher-loc>London, UK</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="doi">10.12688/f1000research.137349.1</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Research Article</subject>
                </subj-group>
                <subj-group>
                    <subject>Articles</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Secondary data analysis of the distribution and determinants of maternal and child health outcomes across Kenya&#x2019;s 47 counties</article-title>
                <fn-group content-type="pub-status">
                    <fn>
                        <p>[version 1; peer review: 1 approved with reservations]</p>
                    </fn>
                </fn-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author" corresp="yes">
                    <name>
                        <surname>Okungu</surname>
                        <given-names>Vincent</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Funding Acquisition</role>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Project Administration</role>
                    <role content-type="http://credit.niso.org/">Resources</role>
                    <role content-type="http://credit.niso.org/">Software</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="corresp" rid="c1">a</xref>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <aff id="a1">
                    <label>1</label>Public &amp; Global Health, University of Nairobi, Nairobi, Nairobi County, 00200, Kenya</aff>
            </contrib-group>
            <author-notes>
                <corresp id="c1">
                    <label>a</label>
                    <email xlink:href="mailto:vokungu@uonbi.ac.ke">vokungu@uonbi.ac.ke</email>
                </corresp>
                <fn fn-type="conflict">
                    <p>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>26</day>
                <month>10</month>
                <year>2023</year>
            </pub-date>
            <pub-date pub-type="collection">
                <year>2023</year>
            </pub-date>
            <volume>12</volume>
            <elocation-id>1408</elocation-id>
            <history>
                <date date-type="accepted">
                    <day>26</day>
                    <month>9</month>
                    <year>2023</year>
                </date>
            </history>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2023 Okungu V</copyright-statement>
                <copyright-year>2023</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <self-uri content-type="pdf" xlink:href="https://f1000research.com/articles/12-1408/pdf"/>
            <abstract>
                <sec>
                    <title>Introduction</title>
                    <p>There are 47 semi-autonomous counties in Kenya that are in-charge of financing and delivery of healthcare. Although reports exist that demonstrate how the counties differ in socioeconomic status, disease burden, and health outcomes, such reports often fail to show where the greatest inequities lie, and what actually drives them. This analysis is meant to guide better targeting of resources to achieve a greater impact on maternal and child health outcomes.</p>
                </sec>
                <sec>
                    <title>Methods</title>
                    <p>Secondary data sources were analyzed to determine the variations in inequities in Kenyan counties. The inequities and their distribution in the 47 counties were assessed using a Lorenz curve and principal component analysis (PCA). A regression analysis evaluated the relationship between key outcomes- maternal mortality, under-five mortality, full immunization coverage (DPT3), the incidence of diarrhea, and under-five stunting, as the dependent variables, and years of education for women 15 &#x2013; 49 years, county health financing per capita, public insurance coverage, population per facility, public nurses/100000, doctors/100000 people, poverty headcount rate, and gender inequality index (GII), as the independent variables.</p>
                </sec>
                <sec>
                    <title>Findings</title>
                    <p>Vaccine coverage (Gini Index 0.063) is the most equitably distributed outcome in the country, followed by under-five mortality (GI=0.124). Maternal mortality has the highest inequity (GI=0.381), followed by the distribution of public sector nurses (GI=0.317). County government funding of health per capita also shows wide variations between counties (GI= 0.230) suggesting different levels of expenditure and prioritization. Vaccine coverage and U-5 mortality are the most evenly distributed across the counties. The key drivers of maternal mortality are education of women of reproductive age (p= 0.001), gender inequality (p=0.002), and congestion at health facilities (0.001).</p>
                </sec>
                <sec>
                    <title>Conclusion</title>
                    <p>Promising approaches and interventions to reduce inequity do exist, which includes UHC whose focus should be on reducing geographical, economic, sociocultural, and gender barriers to healthcare.</p>
                </sec>
            </abstract>
            <kwd-group kwd-group-type="author">
                <kwd>MCH</kwd>
                <kwd>Counties</kwd>
                <kwd>Kenya</kwd>
                <kwd>Inequities</kwd>
                <kwd>Outcome</kwd>
            </kwd-group>
            <funding-group>
                <award-group id="fund-1">
                    <funding-source>N/A</funding-source>
                    <award-id>N/A</award-id>
                </award-group>
                <funding-statement>The author(s) declared that no grants were involved in supporting this work.</funding-statement>
            </funding-group>
        </article-meta>
    </front>
    <body>
        <sec id="sec1" sec-type="intro">
            <title>Introduction</title>
            <p>The end of the Millennium Development Goals (MDGs) era (2000&#x2013;2015) witnessed significant improvements in maternal and child health (MCH) in sub-Saharan Africa (SSA). For example, the average maternal mortality ratio in the region declined by 45% since 1990 and under-five (U-5) mortality 2000&#x2013;2015 reduced at a rate of 4.1% per annum, more than twice faster compared with the decade before.
                <sup>
                    <xref ref-type="bibr" rid="ref1">1</xref>
                </sup> The commencement of the 
                <ext-link ext-link-type="uri" xlink:href="https://sdgs.un.org/goals">Sustainable Development Goals</ext-link> (SDGs) is to build on the gains made in improving maternal and child health outcomes. Despite these efforts, there are still major inequalities in the outcomes within countries that are driven by specific determinants of health including education, income, age, housing conditions, food and nutrition, physical environment, ethnicity/race, and place of residence.
                <sup>
                    <xref ref-type="bibr" rid="ref2">2</xref>
                </sup>
                <sup>&#x2013;</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref5">5</xref>
                </sup> However, there are other macro- and micro-level factors that influence maternal and child health outcomes and perpetuate inequity between and within nations. These include health insurance coverage, population per health facility, public nurses/100000, doctors/100000 people, poverty headcount rate,
                <sup>
                    <xref ref-type="bibr" rid="ref6">6</xref>
                </sup> and gender inequality.
                <sup>
                    <xref ref-type="bibr" rid="ref7">7</xref>
                </sup> These factors play important roles in influencing outcomes such as maternal mortality, under-five stunting, under-five mortality, vaccine coverage (DPT3), and incidence of child diarrhea.
                <sup>
                    <xref ref-type="bibr" rid="ref6">6</xref>
                </sup>
            </p>
            <p>Health inequities present an unjustifiable challenge to mankind because they are the result of economic and social conditions that ultimately determine human health and wellbeing.
                <sup>
                    <xref ref-type="bibr" rid="ref8">8</xref>
                </sup> Hence, there is a greater justification for progressive and inclusive policies designed and implemented by governments to respond to a cross section of the economic and social determinants of health.
                <sup>
                    <xref ref-type="bibr" rid="ref9">9</xref>
                </sup> However, such policies need to be formulated in ways that they best target areas with the greatest inequities while addressing the most impactful root causes for the benefit of the whole society.
                <sup>
                    <xref ref-type="bibr" rid="ref10">10</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref11">11</xref>
                </sup> This is in line with UN SDGs that pledged to &#x201c;leave no one behind&#x201d;.
                <sup>
                    <xref ref-type="bibr" rid="ref12">12</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref13">13</xref>
                </sup>
            </p>
            <p>This review set out to answer two important questions- the one is to demonstrate the how inequities around maternal and child health outcomes compare with each other (using the Lorenz curve), and the other to assess the extent to which economic and social determinants drive MCH outcome inequities in the Kenyan counties. The analysis is meant to guide better targeting of resources to achieve greater impact in MCH outcomes.</p>
            <p>Kenya devolved the public health sector after the 
                <ext-link ext-link-type="uri" xlink:href="http://www.parliament.go.ke/sites/default/files/2023-03/The_Constitution_of_Kenya_2010.pdf">2010 Constitution</ext-link> was inaugurated. The new constitution recognizes 47 semi-autonomous counties that are directly in-charge of financing and delivery of healthcare. Although there are reports
                <sup>
                    <xref ref-type="bibr" rid="ref14">14</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref15">15</xref>
                </sup> demonstrating how the counties differ in socio-economic status, disease burden and health outcomes, such reports often fail to show where the greatest equity and inequity lie, and what actually drives them. Friedman, Gostin et al
                <sup>
                    <xref ref-type="bibr" rid="ref16">16</xref>
                </sup> state that aggregated data mask deep unfairness in the distribution of good health, much as a growing gross domestic product can mask highly unequal distribution of wealth.</p>
            <p>Kenya has made significant strides in improving MCH outcomes
                <sup>
                    <xref ref-type="bibr" rid="ref17">17</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref18">18</xref>
                </sup> which include reductions incidence of diarrhea, increasing vaccine coverage, lower respiratory infections, increased skilled birth attendant, and increasing insurance coverage through the free maternal care program- 
                <ext-link ext-link-type="uri" xlink:href="https://www.nhif.or.ke/wp-content/uploads/2021/09/Linda_Mama_Brochure.pdf">Linda Mama</ext-link>. However, achieving equitable distribution of outcomes across the counties remains a challenge.
                <sup>
                    <xref ref-type="bibr" rid="ref19">19</xref>
                </sup> This may explain the fact that MCH outcomes such as mortality remains unacceptably high
                <sup>
                    <xref ref-type="bibr" rid="ref17">17</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref18">18</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref20">20</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref21">21</xref>
                </sup> because resources may not be properly targeted. Knowledge about the drivers of inequity is of particular interest to policy makers for deciding where to intervene to improve, especially MCH, and move closer to the goals of universal health coverage (UHC).
                <sup>
                    <xref ref-type="bibr" rid="ref22">22</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref23">23</xref>
                </sup> Consequently, studies on the major variations in maternal and child health outcomes are necessary to inform policy and target resources in the most impactful areas. The choice of measurement variables in this review is based on key social and economic conditions considered to have high impact on maternal and child health outcomes.
                <sup>
                    <xref ref-type="bibr" rid="ref6">6</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref7">7</xref>
                </sup>
            </p>
        </sec>
        <sec id="sec2" sec-type="methods">
            <title>Methods</title>
            <p>This was a rapid review of national level data on maternal and child health. Secondary data sources were purposively selected for purposes of this study; i.e., only reports with quantitative information were targeted. The Institute of Health Metrics and Evaluation&#x2019;s (IHME) local burden of disease
                <sup>
                    <xref ref-type="bibr" rid="ref24">24</xref>
                </sup> provided data on key health indicators including U-5 stunting, vaccine coverage, U-5 mortality, diarrhea and years of education for women 15 &#x2013; 49 years of age for the year 2015. The second data source included summaries of various national survey reports in the County Health Fact Sheets by the Health Policy Project,
                <sup>
                    <xref ref-type="bibr" rid="ref6">6</xref>
                </sup> 2014 and 2015 data. Data collected from this summary included the following: county government financing per capita (USD); insurance coverage by the National Hospital Insurance Fund (NHIF), number of people per facility by county (calculated), public doctor to population ratio and public nurses to population ratio. Data on maternal mortality rates were captured from a 2015 report by UNICEF.
                <sup>
                    <xref ref-type="bibr" rid="ref25">25</xref>
                </sup> Data on poverty headcount rates were sourced from the Open Institute (data for 2015).
                <sup>
                    <xref ref-type="bibr" rid="ref26">26</xref>
                </sup> Data for human development index (HDI) and gender inequality index (GII) were mined from a UNDP/Government of Kenya (GOK) report (2017).
                <sup>
                    <xref ref-type="bibr" rid="ref7">7</xref>
                </sup> The data represented all 47 counties in Kenya (
                <xref ref-type="fig" rid="f1">Figure 1</xref>).</p>
            <fig fig-type="figure" id="f1" orientation="portrait" position="float">
                <label>Figure 1. </label>
                <caption>
                    <title>Map showing the 47 Kenyan counties.</title>
                    <p>
                        <italic toggle="yes">(Source:</italic> Wikipedia Copyrighted free use)
                        <sup>
                            <xref ref-type="bibr" rid="ref27">27</xref>
                        </sup>
                    </p>
                </caption>
                <graphic id="gr1" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/150508/78c52a9d-0910-4a98-9be8-53b89d9e4c47_figure1.gif"/>
            </fig>
            <p>A Lorenz curve and Gini Index were constructed to assess the inequalities within counties based on the following indicators recommended by the Health Policy Project as the key measures of inequity between counties
                <sup>
                    <xref ref-type="bibr" rid="ref6">6</xref>
                </sup>: immunization coverage (DPT3), U-5 mortality, child diarrhea, maternal mortality rates (MMR), county government financing per capita (converted to 2015 USD), insurance coverage by the National Hospital Insurance Fund (NHIF), poverty head-count (food), public nurses to population ratio and number of people per facility.
                <disp-formula id="e1">
                    <mml:math display="block">
                        <mml:mi>L</mml:mi>
                        <mml:mfenced close=")" open="(">
                            <mml:mi>y</mml:mi>
                        </mml:mfenced>
                        <mml:mo>=</mml:mo>
                        <mml:mfrac>
                            <mml:mrow>
                                <mml:msubsup>
                                    <mml:mo>&#x222b;</mml:mo>
                                    <mml:mn>0</mml:mn>
                                    <mml:mi>y</mml:mi>
                                </mml:msubsup>
                                <mml:mi mathvariant="italic">xdF</mml:mi>
                                <mml:mfenced close=")" open="(">
                                    <mml:mi>x</mml:mi>
                                </mml:mfenced>
                            </mml:mrow>
                            <mml:mi>&#x03bc;</mml:mi>
                        </mml:mfrac>
                        <mml:mo>,</mml:mo>
                    </mml:math>
                </disp-formula>&#x2026; where 
                <italic toggle="yes">F</italic>(
                <italic toggle="yes">y</italic>) is the cumulative distribution function of ordered individuals and 
                <italic toggle="yes">&#x03bc;</italic> is the average size.</p>
            <p>In addition, the distribution of selected variables was demonstrated using the principal component analysis (PCA). Finally, a multivariate whole model stepwise regression analysis was conducted to determine the role of the following key independent variables: years of education for women 15 &#x2013; 49 years, county health financing per capita, NHIF insurance coverage, population per facility, public nurses/100000, doctors/100000 people, poverty headcount rate, and gender inequality index (GII) in determining a number of health outcomes. The outcomes are: stunting (U-5), U-5 mortality, MMR, vaccine coverage (DPT3) and incidence of diarrhea.</p>
        </sec>
        <sec id="sec3" sec-type="results">
            <title>Results</title>
            <p>The Lorenz Curve (
                <xref ref-type="fig" rid="f2">Figure 2</xref>) shows levels of inequality by various indicators.</p>
            <fig fig-type="figure" id="f2" orientation="portrait" position="float">
                <label>Figure 2. </label>
                <caption>
                    <title>The Lorenz curve.</title>
                </caption>
                <graphic id="gr2" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/150508/78c52a9d-0910-4a98-9be8-53b89d9e4c47_figure2.gif"/>
            </fig>
            <p>Vaccine coverage with a Gini Index (GI) of 0.063 (
                <xref ref-type="table" rid="T1">Table 1</xref>) is the most equitably distributed outcome in the country followed by U-5 mortality rate (GI=0.124). Both vaccine coverage and U-5 mortality rate are closely related; i.e. low vaccine coverage potentially leads to high U-5 mortality rates. Maternal health has the highest inequity (GI=0.381) followed by of the distribution of nurses in the public health sector in each county (GI=0.317). Both vaccine coverage and maternal mortality ratios are often dependent on level of education of women of reproductive age (15 &#x2013; 49 years). County government funding of health per capita also shows wide variations between counties (GI= 0.230) suggesting different levels of expenditure and prioritization of the health sector by each of the 47 county governments.</p>
            <table-wrap id="T1" orientation="portrait" position="float">
                <label>Table 1. </label>
                <caption>
                    <title>Gini coefficient.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1" valign="top">Under 5 mortality rate</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Vaccine coverage (DPT3)</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Maternal mortality rate (MMR)</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Government funding per capita</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Public Insurance (NHIF) coverage</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Nurses/100000</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Population per facility</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Poverty headcount</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.124</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.063</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.381</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.230</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.185</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.317</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.215</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.195</td>
                        </tr>
                    </tbody>
                </table>
            </table-wrap>
            <p>
                <xref ref-type="fig" rid="f3">Figures 3a</xref> to 
                <xref ref-type="fig" rid="f3">3i</xref> confirm how some of the outcomes and the determining factors are distributed across the 47 counties.</p>
            <fig fig-type="figure" id="f3" orientation="portrait" position="float">
                <label>Figure 3. </label>
                <caption>
                    <title>&#x2009;</title>
                    <p>a: Vaccine coverage (DPT3). b: Under-5 mortality rate (U5MR). c: Maternal mortality rate (MMR). d: Population per health facility. e: Under-5 stunting. f: Incidence of diarrhoea. g: Gender inequality index (GII). h: Educational achievement. i: Coverage by the NHIF.</p>
                </caption>
                <graphic id="gr3" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/150508/78c52a9d-0910-4a98-9be8-53b89d9e4c47_figure3.gif"/>
            </fig>
            <p>The figures show that vaccine coverage (
                <xref ref-type="fig" rid="f3">Figure 3a</xref>) and U-5 mortality (
                <xref ref-type="fig" rid="f3">Figure 3b</xref>) are the most evenly distributed across the counties. On the other hand, MMR (
                <xref ref-type="fig" rid="f3">Figure 3c</xref>) and population per public sector health facility (
                <xref ref-type="fig" rid="f3">Figure 3d</xref>), are the most unevenly distributed. The distribution of mean U-5 stunting (
                <xref ref-type="fig" rid="f3">Figure 3e</xref>), incidence of diarrhea (
                <xref ref-type="fig" rid="f3">Figure 3f</xref>), and gender inequality index (GII) (
                <xref ref-type="fig" rid="f3">Figure 3g</xref>) tend to have normal distributions across the 47 counties, suggesting that all counties require the same level of attention when it comes to these variables. The educational attainment of women of reproductive age (
                <xref ref-type="fig" rid="f3">Figure 3h</xref>), and coverage by the public insurance agency, the NHIF (
                <xref ref-type="fig" rid="f3">Figure 3i</xref>) tend to have similar distribution suggesting that a correlation between insurance coverage educational attainment.</p>
            <p>
                <xref ref-type="table" rid="T2">Table 2</xref> presents the results of a multivariate whole model stepwise analysis.</p>
            <table-wrap id="T2" orientation="portrait" position="float">
                <label>Table 2. </label>
                <caption>
                    <title>Multivariate analysis of the determinants of MCH outcomes in Kenya.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1" valign="top">Variable name</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Coefficient</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Standard deviation</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">t</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">P-value</th>
                            <th align="left" colspan="2" rowspan="1" valign="top">[95% Confidence Interval]</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Mean stunting &lt;5</bold>
                            </td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Years of education (women 15-49)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1.214</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.401</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.03</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.004</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.4039</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.0248</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Insurance cover (NHIF)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.246</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.117</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-2.10</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.042</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.4817</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.0095</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Persons/facility</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.0001</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.0001</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1.06</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.294</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.0003</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.0011</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Public nurses/100000</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.012</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.019</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.61</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.545</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.0268</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.0501</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Poverty headcount rate</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.210</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.066</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.17</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.003</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.0760</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.3438</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <xref ref-type="table-fn" rid="tfn1">*</xref>Gender inequality index (GII)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">20.823</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">6.210</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.35</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.002</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">8.2830</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">33.3639</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Under-five mortality/1000</bold>
                            </td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Years of education (women 15-49)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.723</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.807</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.90</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.376</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.9071</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.3528</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Insurance cover (NHIF)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.108</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.235</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.46</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.649</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.3670</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.5827</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Persons/facility</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.001</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.001</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1.18</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.245</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.0006</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.0023</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Public nurses/100000</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.085</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.038</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-2.23</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.031</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.1627</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.0080</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Poverty headcount rate</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.034</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.133</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.26</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.797</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.2348</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.3038</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Gender inequality index</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">59.129</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">12.489</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4.73</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">&lt;0.001</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">33.9070</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">84.3505</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Full vaccination coverage with DPT3</bold>
                            </td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Years of education (women 15-49)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.445</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.831</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4.14</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">&lt;0.001</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1.7662</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">5.1244</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Insurance cover (NHIF)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.572</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.242</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.36</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.023</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.0825</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1.0608</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Persons/facility</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.002</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.001</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-2.06</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.046</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.0030</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.0001</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Public nurses/100000</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.074</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.039</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1.88</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.068</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.0056</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.1538</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Poverty headcount rate</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.318</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.137</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.31</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.026</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.0404</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.5952</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Gender inequality index</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">55.042</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">12.865</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4.28</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">&lt;0.001</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">29.0603</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">81.0242</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Incidence of diarrhea</bold>
                            </td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Years of education (women 15-49 years)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.370</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.534</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.69</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.492</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.7075</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1.4483</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Public insurance coverage (NHIF)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.004</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.155</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.03</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.979</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.3099</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.3181</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Persons/health facility</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.001</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.000</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1.14</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.261</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.0004</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.0015</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Public nurses/100000</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.052</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.025</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-2.03</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.049</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.1027</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.0003</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Poverty headcount rate</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.127</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.088</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1.44</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.159</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.0515</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.3046</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Gender inequality index</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">37.492</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">8.259</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4.54</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">&lt;0.001</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">20.8129</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">54.1714</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Maternal mortality/100000</bold>
                            </td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Years of education (women 15-49)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-120.115</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">34.724</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-3.46</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.001</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-190.2409</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-49.9894</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Insurance cover (NHIF)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-5.960</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">10.116</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.59</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.559</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-26.3883</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">14.4692</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Persons/facility</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.120</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.031</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.92</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">&lt;0.001</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.0583</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.1818</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Public nurses/100000</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1.214</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1.648</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.74</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.466</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-2.1149</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4.5428</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Poverty headcount rate</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-5.304</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">5.736</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.92</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.361</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-16.8896</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">6.2806</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Gender inequality index</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1748.999</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">537.311</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.26</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.002</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">663.8776</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2834.1200</td>
                        </tr>
                    </tbody>
                </table>
                <table-wrap-foot>
                    <fn-group content-type="footnotes">
                        <fn id="tfn1">
                            <label>*</label>
                            <p>The UNDP defines the gender inequality index (GII) as &#x201c;a composite metric of gender inequality using three dimensions: reproductive health, empowerment and the labor market. A low GII value indicates low inequality between women and men, and vice-versa&#x201d;.</p>
                        </fn>
                    </fn-group>
                </table-wrap-foot>
            </table-wrap>
            <sec id="sec4">
                <title>Stunted growth for children below five years of age) (Mean stunting U-5)</title>
                <p>As illustrated by 
                    <xref ref-type="table" rid="T2">Table 2</xref>, the level of education of women of reproductive age (15 &#x2013; 49 years), health insurance coverage by the NHIF, poverty headcount rate, and gender inequality index (GII) have significant influence on mean stunting for children U-5. Having NHIF coverage significantly reduces U-5 stunting (p=0.042) while high gender inequality index (p=0.002) and poverty headcount rate (p=0.003) significantly increase stunting of children U-5. The higher the number of people in a health facility as well as increasing number of nurses in a county, are both associated with increased mean-stunting rates but the differences are insignificant. Interestingly, counties with higher levels of education of women of reproductive age also experience higher rates of stunting for children U-5 (p=0.004). This is in line with the available data which shows that many counties with much lower levels of education for women 15 &#x2013; 49 years old, 
                    <italic toggle="yes">e.g.,</italic> Wajir (1.4 years of education), Turkana (1.6 years) and Garissa (three years) have stunting rates lower than or equal to the national average. The national average for educational achievements of women of reproductive age is 8.6 years, and the national mean stunting rate is about 25% as of 2017. On the other hand, counties with relatively higher levels of education of women of reproductive age including Machakos (9.3% years), Elgeyo Marakwet (8.6 years) and Bomet (8.4 years) have registered above average stunting rates at 27%, 33% and 31%, respectively.</p>
            </sec>
            <sec id="sec5">
                <title>U-5 mortality per 1000 live births</title>
                <p>The findings show that higher levels of education of women 15 &#x2013; 49 years, higher NHIF coverage, number of patients per facility, and poverty headcount rate, all play insignificant roles in influencing U-5 mortality. However, having more nurses in public healthcare facilities significantly reduces U-5 mortality (p= 0.031) while high GII significantly increases U-5 mortality (p= &lt;0.001).</p>
            </sec>
            <sec id="sec6">
                <title>Full immunization coverage (DPT3)</title>
                <p>Counties reporting a high number of patients per facility experience significantly reduced DPT3 coverage (P=0.046) but counties where women (15-49 years) are more educated and have higher NHIF coverage experience significant increases in immunization coverage (p=&lt;0.001 and p= 0.023, respectively). On the other hand, increasing number of nurses in public sector health facilities has no significant effect on immunization coverage (p=0.063). However, poverty headcount rate (p=0.026) and GII (p=&lt;0.001) also unexpectedly increase immunization coverage. This has to do with externalities such as the deliberate government effort, among other stakeholders, to increase immunization coverage in poor and marginalized areas.</p>
            </sec>
            <sec id="sec7">
                <title>Incidence of diarrhea</title>
                <p>Incidence of diarrhea in the counties has no significant relationship with a number of variables: years of education of women of reproductive age, NHIF coverage, number of people in a public sector health facility, and poverty headcount rate. However, the incidence of diarrhea is significantly reduced by increasing the number of public nurses in a county (p=0.049) but high GII, on the other hand, significantly increases the incidence of diarrhea (p= &lt;0.001).</p>
            </sec>
            <sec id="sec8">
                <title>Maternal mortality/100000 live births</title>
                <p>Years of education of women of reproductive age drastically reduce MMR (p=0.001). At the same time, counties experiencing high GII and congestion in health facilities have significant increases in MMR (p=0.002 and p=0.001 respectively). Although provision of NHIF coverage also reduces MMR, this reduction is insignificant. The roles of the number of public nurses and the poverty headcount rate in a county are insignificant in influencing MMR.</p>
            </sec>
        </sec>
        <sec id="sec9" sec-type="discussion">
            <title>Discussion</title>
            <p>Maternal mortality rate (MMR) is globally the most inequitably distributed health outcome indicator.
                <sup>
                    <xref ref-type="bibr" rid="ref1">1</xref>
                </sup> For instance, in SSA about 1000 women die per 100,000 live births, compared to 24 deaths per 100,000 live births in European countries. In Kenya, this type of inequity is worse at the sub-national level where more than 2000 deaths per 100,000 live births are reported in some counties against less than 200 deaths per 100,000 live births in others.
                <sup>
                    <xref ref-type="bibr" rid="ref25">25</xref>
                </sup> The Kenya reproductive, maternal, neonatal, child and adolescent health (RMNCAH) investment framework aims to ensure &#x201c;there are no preventable deaths of women, new-borns or children and; no preventable still-births, where every pregnancy is wanted, every birth celebrated and accounted for &#x2026;&#x201d;.
                <sup>
                    <xref ref-type="bibr" rid="ref28">28</xref>
                </sup> This investment framework is strengthened by the assurance that as the country makes progress towards UHC, health inequities including maternal mortality, U-5 mortality, immunization coverage, child stunting, and incidence of diarrhea across the country, would diminish.</p>
            <p>The results from this study reflect the global trends in MMR as the most inequitable outcome where, across the counties, the distribution matrix showed that most of the burden rests on a few counties, particularly those in the remote northern region, and the lake region which has a high HIV/AIDS burden. It needs emphasis that populations experiencing vulnerabilities and poor access to healthcare including those in urban slums, marginalized populations, refugees, and displaced people, need to be brought into the health system,
                <sup>
                    <xref ref-type="bibr" rid="ref29">29</xref>
                </sup> to address health inequities.</p>
            <p>Whilst a positive outcome in MMR is strongly and expectedly linked with the level of education of women of reproductive age, perhaps one of the most interesting findings is the significant roles that gender inequality (GII) and congestion at public sector health facilities play in increasing MMR. Investments targeting both areas would be recommended, based on the results, to help address MMR outcomes particularly in northern Kenya, and the lake region. The GII is particularly of interest as it has significant influence on all the outcomes. It is linked with women&#x2019;s empowerment both culturally and economically to be able to make decisions on when and how to access care, and whether or not to get pregnant. Recent reports indicate that women in many parts of Kenya are significantly disempowered and lack decision making power.
                <sup>
                    <xref ref-type="bibr" rid="ref30">30</xref>
                </sup>
            </p>
            <p>As the findings suggest, outcomes such as full immunization coverage with DPT3, is already trending toward the line of equity, and as the results show, is driven largely by improved levels of education of women of reproductive age, reduced congestions at health facilities, and public health insurance coverage, which together tend to improve access to health services. Aalemi et al.,
                <sup>
                    <xref ref-type="bibr" rid="ref31">31</xref>
                </sup> had similar findings in their study of factors driving immunization coverage in Afghanistan. However, despite the progress made in DPT3 coverage, a few counties including Mandera (36%), West Pokot (54%), Wajir (60%), and Migori (65%) record the lowest coverage, and therefore, require research and more focused intervention than currently practiced to improve their immunization coverage.</p>
            <p>The U-5MR in Kenya is also relatively equitable even though some counties such as Homa Bay (75 deaths per 1000 live births), Migori (73/1000), Busia (63/1000), Kisumu (58/1000), Vihiga (58/1000) and Kakamega (56/1000) are below the national average (44/1000). It is noteworthy that all these counties registering unacceptably high U-5MR are based in the western/lake region of the country where the prevalence of HIV/AIDS is quite high. There is a direct correlation between prevalence of HIV/AIDS and MCH outcomes.
                <sup>
                    <xref ref-type="bibr" rid="ref32">32</xref>
                </sup>
                <sup>&#x2013;</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref34">34</xref>
                </sup> All things constant, it could be fair to conclude that child survival in these counties and a few others, would be greatly improved with more interventions focused on reducing the incidence of HIV infections. In addition, authors such Pillai and Maleku
                <sup>
                    <xref ref-type="bibr" rid="ref35">35</xref>
                </sup> suggest that other factors including availability of diverse sources of water, age at first birth, wealth status and urban residence are critical to improvements in child health outcomes. All these factors need to be considered in designing interventions to improve under-5 mortality in the affected counties.</p>
            <p>There are counter-intuitive results; e.g., increasing poverty head count rate relate positively with reducing MMR. This can be attributed to national interventions such as the Linda Mama health insurance initiative that provide free maternal and child health services and particularly targets vulnerable women. Such outcomes can also be partially attributed to efforts by organizations such as 
                <ext-link ext-link-type="uri" xlink:href="https://www.unicef.org/kenya/health">UNICEF</ext-link> that target improvements in MCH in poor, hard-to-reach counties. These interventions have tended to improve equity and it is evident from the results that the NHIF coverage for example, tends to be one of the closest to the line of equity because all MCH services are eligible for coverage. In addition, the results show that counties with less educated women record lower stunting rates, which indicates the role of external interventions in improving child nutrition in marginalized counties. Programs such as Nutrition and Health Program Plus, and those under Nutrition International, tend to target highly vulnerable communities to eliminate nutrition-related stunting, and promote child survival.</p>
            <p>Counter-intuitive results are not a rarity. In Ghana, research shows that achieving UHC was associated with increased unmet need for family planning.
                <sup>
                    <xref ref-type="bibr" rid="ref36">36</xref>
                </sup> Moreover, fertility levels associated remained high, with limited improvements among young women only.
                <sup>
                    <xref ref-type="bibr" rid="ref36">36</xref>
                </sup> As such, UHC is insufficient for achieving socially accessible family planning care unless the social constraints to the reproductive autonomy of women are addressed.</p>
            <p>Beyond the macro-level data, it is important, as recommended by Achoki 
                <italic toggle="yes">et al.,</italic>
                <sup>
                    <xref ref-type="bibr" rid="ref15">15</xref>
                </sup> for decision makers to use evidence on burden of disease at sub-national level to target health interventions and address inequities in MCH outcomes. In addition, the preponderance of inequities in the distribution of MMR across the 47 counties of Kenya calls for a re-think of investment decisions in MCH services in Kenya. One recommendation is the use of technologies such as 
                <ext-link ext-link-type="uri" xlink:href="https://www.philips.co.ke/healthcare/sites/lumify-handheld-ultrasound?origin=7_700000002476309_71700000090414859_58700007651208770_43700069206274293&amp;dmcm=Cj0KCQjwoK2mBhDzARIsADGbjeq-3nOdr8J0AdgSRoDmtf_rx-T6eHwEVZqhQn4flCc4be130istlbEaAvh6EALw_wcB&amp;gclid=Cj0KCQjwoK2mBhDzARIsADGbjeq-3nOdr8J0AdgSRoDmtf_rx-T6eHwEVZqhQn4flCc4be130istlbEaAvh6EALw_wcB&amp;gclsrc=aw.ds">Lumify</ext-link> because it is known to improve MCH outcomes, particularly in resource-poor, hard-to-reach settings. In Rwanda for example, Royal Philips and PURE (Point-of-care Ultrasound in Resource-limited Environments) rolled out a unique tele-ultrasound mentorship program to provide much needed diagnostic ultrasound training to health workers in Rwanda.
                <sup>
                    <xref ref-type="bibr" rid="ref37">37</xref>
                </sup>
            </p>
            <p>Thus far, the analysis reveals some of the most inequitably distributed socioeconomic conditions, and outcomes among counties, which are often not apparent to decision makers. In this context, health interventions need to have an equity focus that supports the delivery of MCH services through the lens of intra-county variations in outcomes such as MMR, and socio-economic conditions including GII, congestion at health facilities, availability of nurses in public sector health facilities, burden of infectious disease, and poverty headcount rate. Promising approaches and interventions to reduce inequity do exist. These approaches include UHC whose focus should be on reducing geographical, economic, sociocultural, and gender barriers to healthcare.</p>
        </sec>
    </body>
    <back>
        <sec id="sec12" sec-type="data-availability">
            <title>Data availability</title>
            <p>No data are associated with this article.</p>
        </sec>
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    <sub-article article-type="reviewer-report" id="report421186">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.150508.r421186</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Khalid</surname>
                        <given-names>Samina Naeem</given-names>
                    </name>
                    <xref ref-type="aff" rid="r421186a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-9838-7279</uri>
                </contrib>
                <aff id="r421186a1">
                    <label>1</label>MNCH (Maternal, Neonatal and Child Health) Department, Professor and Head of MNCH Department, Health Services Academy, Islamabad, ICT, Pakistan</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>14</day>
                <month>10</month>
                <year>2025</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2025 Khalid SN</copyright-statement>
                <copyright-year>2025</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport421186" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.137349.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>This manuscript presents a valuable and policy-relevant analysis of sub-national inequities in maternal and child health (MCH) outcomes across Kenya. Using multiple national datasets, it quantifies inequalities through Lorenz curves and Gini indices and explores their determinants using regression models. The topic is highly significant for informing equitable health policy and resource allocation in Kenya&#x2019;s devolved health system and contributes to broader discussions on achieving Universal Health Coverage (UHC).</p>
            <p> </p>
            <p> However, the paper requires major revisions to strengthen its 
                <bold>methodological clarity, results presentation, interpretation of counter-intuitive findings, and coherence across sections</bold> before it can be considered for indexing.</p>
            <p> </p>
            <p> 
                <bold>1. Summary and General Assessment</bold>
            </p>
            <p> </p>
            <p> The study explores disparities in MCH indicators, maternal mortality ratio (MMR), under-five mortality rate (U5MR), stunting, immunization coverage, and diarrhea incidence across Kenya&#x2019;s 47 counties. It also assesses the association between these outcomes and socio-economic determinants such as education, gender inequality, and poverty.</p>
            <p> </p>
            <p> The analysis is conceptually sound and policy-relevant, yet several methodological and reporting issues limit its interpretability and transparency.</p>
            <p> </p>
            <p> 
                <bold>2. Strengths</bold> 
                <list list-type="bullet">
                    <list-item>
                        <p>
                            <bold>Timely and Relevant Topic:</bold> The focus on intra-country MCH inequities in a devolved health system is both timely and highly relevant.</p>
                    </list-item>
                    <list-item>
                        <p>
                            <bold>Comprehensive Scope:</bold> The inclusion of multiple MCH indicators provides a broad picture of health disparities.</p>
                    </list-item>
                    <list-item>
                        <p>
                            <bold>Appropriate Analytical Tools:</bold> The use of Lorenz curves, Gini coefficients, and regression modeling aligns well with the objectives.</p>
                    </list-item>
                    <list-item>
                        <p>
                            <bold>Policy Implications:</bold> The findings can inform evidence-based allocation of health resources and interventions aimed at reducing inequality.</p>
                    </list-item>
                    <list-item>
                        <p>
                            <bold>Use of Credible Data Sources:</bold> The study integrates reputable datasets (IHME, UNICEF, UNDP, Open Institute, and Health Policy Project).</p>
                    </list-item>
                </list> 
                <bold>3. Weaknesses and Areas for Improvement</bold>
            </p>
            <p> </p>
            <p> 
                <bold>a. Study Design and Methods</bold> 
                <list list-type="bullet">
                    <list-item>
                        <p>
                            <bold>Incorrect Study Design Label:</bold> The term 
                            <italic>&#x201c;rapid review&#x201d;</italic> is inaccurate. This is a 
                            <italic>secondary data analysis</italic> of national datasets. This correction must be applied throughout the manuscript.</p>
                    </list-item>
                    <list-item>
                        <p>
                            <bold>Data Harmonization:</bold> The process of merging datasets from different years (2014&#x2013;2017) is not adequately described. The author should explain how differences in data collection years, definitions, and methods were managed and justify the comparability of indicators.</p>
                    </list-item>
                    <list-item>
                        <p>
                            <bold>Regression Analysis:</bold> 
                            <list list-type="bullet">
                                <list-item>
                                    <p>The term 
                                        <italic>&#x201c;multivariate whole model stepwise regression&#x201d;</italic> requires more detail. Specify inclusion/removal criteria (e.g., p-value thresholds, AIC) and confirm that diagnostic checks (e.g., multicollinearity, heteroskedasticity) were performed.</p>
                                </list-item>
                                <list-item>
                                    <p>Clearly state dependent and independent variables for each model.</p>
                                </list-item>
                                <list-item>
                                    <p>Provide full results for all models in a 
                                        <bold>complete regression table</bold> including coefficients, standard errors, confidence intervals, and p-values.</p>
                                </list-item>
                            </list> </p>
                    </list-item>
                    <list-item>
                        <p>
                            <bold>Principal Component Analysis (PCA):</bold> Results are mentioned but not presented. Either include a table of factor loadings or remove references to PCA.</p>
                    </list-item>
                    <list-item>
                        <p>
                            <bold>Assumptions and Validity:</bold> Briefly justify methodological assumptions of the Lorenz curve and PCA for non-econometric readers.</p>
                    </list-item>
                </list> 
                <bold>b. Results</bold> 
                <list list-type="bullet">
                    <list-item>
                        <p>
                            <bold>Incomplete Reporting:</bold> The regression results (Table 2) are incomplete. A full standard table is required for transparency.</p>
                    </list-item>
                    <list-item>
                        <p>
                            <bold>PCA Results Missing:</bold> If PCA is retained, present its results clearly; if not, remove it entirely.</p>
                    </list-item>
                    <list-item>
                        <p>
                            <bold>Counter-intuitive Findings:</bold> The positive association between women&#x2019;s education and stunting, and the negative link between poverty and MMR, are acknowledged but insufficiently interpreted. These require a deeper and evidence-based discussion.</p>
                    </list-item>
                    <list-item>
                        <p>
                            <bold>Causal Statements:</bold> Avoid causal wording (e.g., &#x201c;low vaccine coverage leads to high U5MR&#x201d;). Rephrase to emphasize associations rather than causation.</p>
                    </list-item>
                </list> 
                <bold>c. Discussion</bold> 
                <list list-type="bullet">
                    <list-item>
                        <p>
                            <bold>Interpretation of Counter-intuitive Results:</bold> Provide potential explanations grounded in theory or literature (e.g., ecological fallacy, data quality, urbanization effects, or dietary patterns).</p>
                    </list-item>
                    <list-item>
                        <p>
                            <bold>Contextualization:</bold> Link findings to existing national and regional evidence, including evaluations of programs like 
                            <italic>Linda Mama</italic> or 
                            <italic>Beyond Zero</italic>.</p>
                    </list-item>
                    <list-item>
                        <p>
                            <bold>Policy Recommendations:</bold> Current recommendations are too general. Strengthen them by explicitly linking proposed actions to key drivers identified in the analysis (e.g., reducing gender inequality, addressing facility congestion, improving workforce distribution).</p>
                    </list-item>
                    <list-item>
                        <p>
                            <bold>Limitations:</bold> Add a concise limitations paragraph noting the ecological nature of the data, differences in data years, and absence of causal inference.</p>
                    </list-item>
                </list> 
                <bold>d. Presentation and Structure</bold> 
                <list list-type="bullet">
                    <list-item>
                        <p>
                            <bold>Figures and Tables:</bold> Include descriptive captions summarizing key takeaways. Ensure numbering and referencing are consistent.</p>
                    </list-item>
                    <list-item>
                        <p>
                            <bold>Terminology Consistency:</bold> Use &#x201c;population per facility&#x201d; instead of &#x201c;patients per facility.&#x201d;</p>
                    </list-item>
                    <list-item>
                        <p>
                            <bold>Language and Formatting:</bold> Standardize numerical reporting (p-values, CI formatting, spacing). Minor grammatical refinements are needed throughout.</p>
                    </list-item>
                    <list-item>
                        <p>
                            <bold>Data Availability:</bold> The statement &#x201c;No data are associated with this article&#x201d; is misleading. Revise to clarify that all data were obtained from publicly available national datasets and provide their sources or repository links.</p>
                    </list-item>
                </list> 
                <bold>4. Section-wise Specific Comments</bold>
            </p>
            <p> 
                <bold>Abstract</bold> 
                <list list-type="bullet">
                    <list-item>
                        <p>Add years of data analyzed for clarity.</p>
                    </list-item>
                    <list-item>
                        <p>Ensure the methods are accurately described as secondary data analysis.</p>
                    </list-item>
                </list> 
                <bold>Introduction</bold> 
                <list list-type="bullet">
                    <list-item>
                        <p>Strengthen the final paragraph by stating 
                            <bold>specific study objectives</bold> rather than broad aims.</p>
                    </list-item>
                </list> 
                <bold>Methods</bold> 
                <list list-type="bullet">
                    <list-item>
                        <p>Expand description of dataset integration, harmonization, and variable standardization.</p>
                    </list-item>
                    <list-item>
                        <p>Justify analytical approaches and describe regression diagnostics.</p>
                    </list-item>
                </list> 
                <bold>Results</bold> 
                <list list-type="bullet">
                    <list-item>
                        <p>Present 
                            <bold>complete regression tables</bold> for all outcomes.</p>
                    </list-item>
                    <list-item>
                        <p>Add PCA results or remove its mention.</p>
                    </list-item>
                    <list-item>
                        <p>Avoid unsubstantiated causal claims.</p>
                    </list-item>
                </list> 
                <bold>Discussion</bold> 
                <list list-type="bullet">
                    <list-item>
                        <p>Deepen interpretation of counter-intuitive findings.</p>
                    </list-item>
                    <list-item>
                        <p>Tie policy implications directly to empirical results.</p>
                    </list-item>
                    <list-item>
                        <p>Include a brief limitations paragraph.</p>
                    </list-item>
                </list> 
                <bold>Conclusion</bold> 
                <list list-type="bullet">
                    <list-item>
                        <p>Reframe the conclusion to emphasize 
                            <bold>key evidence-based policy levers</bold>, such as addressing gender inequality and redistributing health workforce resources, rather than broad UHC goals.</p>
                    </list-item>
                </list> 
                <bold>References</bold> 
                <list list-type="bullet">
                    <list-item>
                        <p>Ensure citations are up to date and relevant.</p>
                    </list-item>
                </list> 
                <bold>5. Validity and Reliability of the Study</bold>
            </p>
            <p> The analytical framework is suitable for the research objectives, but transparency regarding data harmonization, regression model diagnostics, and PCA implementation is necessary to confirm robustness.</p>
            <p> No ethical or competing interest issues are apparent.</p>
            <p> 
                <bold>6. Summary of Required Revisions</bold> 
                <list list-type="order">
                    <list-item>
                        <p>Correct study design terminology (&#x201c;secondary data analysis&#x201d;).</p>
                    </list-item>
                    <list-item>
                        <p>Clarify and justify data harmonization procedures.</p>
                    </list-item>
                    <list-item>
                        <p>Fully report regression models with coefficients, SEs, and p-values.</p>
                    </list-item>
                    <list-item>
                        <p>Present or remove PCA results.</p>
                    </list-item>
                    <list-item>
                        <p>Strengthen discussion of unexpected findings with literature-backed explanations.</p>
                    </list-item>
                    <list-item>
                        <p>Align policy recommendations directly with statistical findings.</p>
                    </list-item>
                    <list-item>
                        <p>Revise data availability statement for accuracy.</p>
                    </list-item>
                    <list-item>
                        <p>Edit for consistent terminology and formatting.</p>
                    </list-item>
                </list>
            </p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Partly</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Yes</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Partly</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Reviewer Expertise:</p>
            <p>Maternal, Newborn and Child Health, Adolescent Health, Maternal Mortality, Nutrition</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
    </sub-article>
</article>
