<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN" "http://jats.nlm.nih.gov/publishing/1.2/JATS-journalpublishing1.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="research-article" dtd-version="1.2" xml:lang="en">
    <front>
        <journal-meta>
            <journal-id journal-id-type="pmc">F1000Research</journal-id>
            <journal-title-group>
                <journal-title>F1000Research</journal-title>
            </journal-title-group>
            <issn pub-type="epub">2046-1402</issn>
            <publisher>
                <publisher-name>F1000 Research Limited</publisher-name>
                <publisher-loc>London, UK</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="doi">10.12688/f1000research.132580.2</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Research Article</subject>
                </subj-group>
                <subj-group>
                    <subject>Articles</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Teaching critical thinking about health information and choices in secondary schools: human-centred design of digital resources</article-title>
                <fn-group content-type="pub-status">
                    <fn>
                        <p>[version 2; peer review: 1 approved, 2 approved with reservations]</p>
                    </fn>
                </fn-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author" corresp="yes">
                    <name>
                        <surname>Rosenbaum</surname>
                        <given-names>Sarah</given-names>
                    </name>
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                    <uri content-type="orcid">https://orcid.org/0000-0001-8334-7664</uri>
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                    <name>
                        <surname>Chesire</surname>
                        <given-names>Faith</given-names>
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                    <role content-type="http://credit.niso.org/">Data Curation</role>
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                    <role content-type="http://credit.niso.org/">Project Administration</role>
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                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Mugisha</surname>
                        <given-names>Michael</given-names>
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                        <surname>Ssenyonga</surname>
                        <given-names>Ronald</given-names>
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                        <surname>Ochieng</surname>
                        <given-names>Marlyn A</given-names>
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                    <role content-type="http://credit.niso.org/">Data Curation</role>
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                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Simbi</surname>
                        <given-names>Clarisse Marie Claudine</given-names>
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                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Investigation</role>
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                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Investigation</role>
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                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
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                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Rada</surname>
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                    <role content-type="http://credit.niso.org/">Software</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="aff" rid="a6">6</xref>
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                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>V&#x00e1;squez-Laval</surname>
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                    <role content-type="http://credit.niso.org/">Project Administration</role>
                    <role content-type="http://credit.niso.org/">Software</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
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                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Garrido</surname>
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                    <role content-type="http://credit.niso.org/">Software</role>
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                    <name>
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                    <role content-type="http://credit.niso.org/">Investigation</role>
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                    <role content-type="http://credit.niso.org/">Investigation</role>
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                    <role content-type="http://credit.niso.org/">Investigation</role>
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                    <role content-type="http://credit.niso.org/">Investigation</role>
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                    <role content-type="http://credit.niso.org/">Investigation</role>
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                    <role content-type="http://credit.niso.org/">Investigation</role>
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                    <role content-type="http://credit.niso.org/">Investigation</role>
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                    <role content-type="http://credit.niso.org/">Conceptualization</role>
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                        <given-names>Margaret</given-names>
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                    <role content-type="http://credit.niso.org/">Conceptualization</role>
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                    <uri content-type="orcid">https://orcid.org/0000-0001-9789-1927</uri>
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                        <given-names>Nelson</given-names>
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                    <role content-type="http://credit.niso.org/">Conceptualization</role>
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                    <role content-type="http://credit.niso.org/">Conceptualization</role>
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                        <given-names>Simon</given-names>
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                    <xref ref-type="aff" rid="a15">15</xref>
                    <xref ref-type="aff" rid="a16">16</xref>
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                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Oxman</surname>
                        <given-names>Andrew D</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
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                    <role content-type="http://credit.niso.org/">Funding Acquisition</role>
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                        <surname>Oxman</surname>
                        <given-names>Matt</given-names>
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                    <role content-type="http://credit.niso.org/">Conceptualization</role>
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                    <uri content-type="orcid">https://orcid.org/0000-0002-6323-9620</uri>
                    <xref ref-type="aff" rid="a1">1</xref>
                    <xref ref-type="aff" rid="a17">17</xref>
                </contrib>
                <aff id="a1">
                    <label>1</label>Centre for Epidemic Interventions Research, Norwegian Institute of Public Health, Oslo, 0213, Norway</aff>
                <aff id="a2">
                    <label>2</label>Tropical Institute of Community Health and Development in Africa, Kisumu, Kenya</aff>
                <aff id="a3">
                    <label>3</label>Institute of Health and Society, Faculty of Medicine, Universitetet i Oslo, Oslo, Oslo, Norway</aff>
                <aff id="a4">
                    <label>4</label>School of Public Health, College of Medicine and Health Sciences, University of Rwanda, Butare, Southern Province, Rwanda</aff>
                <aff id="a5">
                    <label>5</label>School of Medicine, College of Health Sciences, Makerere University, Kampala, Central Region, Uganda</aff>
                <aff id="a6">
                    <label>6</label>Epistemonikos Foundation, Santiago, Santiago Metropolitan Region, Chile</aff>
                <aff id="a7">
                    <label>7</label>National Curriculum Development Centre, Kampala, Uganda</aff>
                <aff id="a8">
                    <label>8</label>Ministry of Education and Sports, Kampala, Uganda</aff>
                <aff id="a9">
                    <label>9</label>Faculty of Health Sciences, Uganda Martyrs University, Kampala, Central Region, Uganda</aff>
                <aff id="a10">
                    <label>10</label>Ministry of Health, Kampala, Uganda</aff>
                <aff id="a11">
                    <label>11</label>Uganda National Examinations Board, Kampala, Uganda</aff>
                <aff id="a12">
                    <label>12</label>Huma Girls Secondary School, Kisumu, Kenya</aff>
                <aff id="a13">
                    <label>13</label>Kenya Institute of Curriculum Development, Nairobi, Kenya</aff>
                <aff id="a14">
                    <label>14</label>Rwanda Basic Education Board, Kigali, Rwanda</aff>
                <aff id="a15">
                    <label>15</label>Health Systems Research Unit, South African Medical Research Council, Cape Town, South Africa</aff>
                <aff id="a16">
                    <label>16</label>Department of Health Sciences, Norwegian University of Science and Technology (NTNU), &#x00c5;lesund, Norway</aff>
                <aff id="a17">
                    <label>17</label>Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway</aff>
            </contrib-group>
            <author-notes>
                <corresp id="c1">
                    <label>a</label>
                    <email xlink:href="mailto:sarahellen.rosenbaum@fhi.no">sarahellen.rosenbaum@fhi.no</email>
                </corresp>
                <fn fn-type="conflict">
                    <p>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>11</day>
                <month>3</month>
                <year>2024</year>
            </pub-date>
            <pub-date pub-type="collection">
                <year>2023</year>
            </pub-date>
            <volume>12</volume>
            <elocation-id>481</elocation-id>
            <history>
                <date date-type="accepted">
                    <day>6</day>
                    <month>3</month>
                    <year>2024</year>
                </date>
            </history>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2024 Rosenbaum S et al.</copyright-statement>
                <copyright-year>2024</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <self-uri content-type="pdf" xlink:href="https://f1000research.com/articles/12-481/pdf"/>
            <abstract>
                <sec>
                    <title>Background</title>
                    <p>Learning to thinking critically about health information and choices can protect people from unnecessary suffering, harm, and resource waste. Earlier work revealed that children can learn these skills, but printing costs and curricula compatibility remain important barriers to school implementation. We aimed to develop a set of digital learning resources for students to think critically about health that were suitable for use in Kenyan, Rwandan, and Ugandan secondary schools.</p>
                </sec>
                <sec>
                    <title>Methods</title>
                    <p>We conducted work in two phases collaborating with teachers, students, schools, and national curriculum development offices using a human-centred design approach. First, we conducted context analyses and an overview of teaching strategies, prioritised content and collected examples. Next, we developed lessons and guidance iteratively, informed by data from user-testing, individual and group interviews, and school pilots.</p>
                </sec>
                <sec>
                    <title>Results</title>
                    <p>Final resources include online lesson plans, teachers&#x2019; guide, and extra resources, with lesson plans in two modes, for use in a classroom equipped with a blackboard/&#xfb02;ip-chart and a projector. The resources are accessible offline for use when electricity or Internet is lacking. Teachers preferred the projector mode, as it provided structure and a focal point for class attention. Feedback was largely positive, with teachers and students appreciating the learning and experiencing it as relevant. Four main challenges included time to teach lessons; incorrect comprehension; identifying suitable examples; and technical, logistical, and behavioural challenges with a student-computer mode that we piloted. We resolved challenges by simplifying and combining lessons; increasing opportunities for review and assessment; developing teacher training materials, creating a searchable set of examples; and deactivating the student-computer mode.</p>
                </sec>
                <sec>
                    <title>Conclusion</title>
                    <p>Using a human-centred design approach, we created digital resources for teaching secondary school students to think critically about health actions and for training teachers. 
                        <ext-link ext-link-type="uri" xlink:href="https://besmarthealth.org/">Be smart about your health</ext-link> resources are open access and can be translated or adapted to other settings.</p>
                </sec>
            </abstract>
            <kwd-group kwd-group-type="author">
                <kwd>critical thinking</kwd>
                <kwd>critical health literacy</kwd>
                <kwd>informed decision making</kwd>
                <kwd>infodemic</kwd>
                <kwd>health education</kwd>
                <kwd>secondary school</kwd>
                <kwd>educational design</kwd>
                <kwd>human centred design</kwd>
            </kwd-group>
            <funding-group>
                <award-group id="fund-1" xlink:href="http://dx.doi.org/10.13039/501100005416">
                    <funding-source>Norges Forskningsr&#x00e5;d</funding-source>
                    <award-id>69006</award-id>
                </award-group>
                <funding-statement>Grant information: This work was supported by the Research Council of Norway &#13;
Project number 284683, grant no: 69006, awarded to ADO.</funding-statement>
                <funding-statement>
                    <italic>The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</italic>
                </funding-statement>
            </funding-group>
        </article-meta>
        <notes>
            <sec sec-type="version-changes">
                <label>Revised</label>
                <title>Amendments from Version 1</title>
                <p>The revised manuscript includes some new details and clarifications in the Methods section that were requested by the peer reviewer. I have added a short summary in the conclusion section about the results of the trials measuring the effect of these resources and added a reference to the prospective meta-analysis that reports those results. I have also updated reference 52 that was previously listed as "in press".</p>
            </sec>
        </notes>
    </front>
    <body>
        <sec id="sec1" sec-type="intro">
            <title>Introduction</title>
            <p>Claims about how to care for our health are everywhere, spread by friends, family, news media, industry, healthcare professionals, policymakers, researchers, and others. Many of these claims unreliable,
                <sup>
                    <xref ref-type="bibr" rid="ref1">1</xref>
                </sup> but people often lack the skills needed to assess them.
                <sup>
                    <xref ref-type="bibr" rid="ref2">2</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref3">3</xref>
                </sup> When we believe unreliable claims, we might take ineffective or harmful actions, or fail to take helpful actions. The Covid-19 pandemic showed how easily unreliable claims
                <sup>
                    <xref ref-type="bibr" rid="ref4">4</xref>
                </sup>
                <sup>&#x2013;</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref6">6</xref>
                </sup> and research
                <sup>
                    <xref ref-type="bibr" rid="ref7">7</xref>
                </sup>
                <sup>&#x2013;</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref9">9</xref>
                </sup> spread, impacting public trust and protective behaviours.
                <sup>
                    <xref ref-type="bibr" rid="ref10">10</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref11">11</xref>
                </sup>
            </p>
            <p>Publicly debunking untrustworthy information has value, but the effectiveness of this retroactive strategy might be limited. Misinformation, once spread, can be resistant to correction; an alternative narrative may not exist (for instance, there may not be a safe or proven alternative treatment); and individuals may reject the scientific process or the source altogether rather than change their established views about some topics.
                <sup>
                    <xref ref-type="bibr" rid="ref12">12</xref>
                </sup> Pre-emptively &#x2018;inoculating&#x2019; people against misinformation
                <sup>
                    <xref ref-type="bibr" rid="ref13">13</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref14">14</xref>
                </sup> by teaching them to think critically about claims of what works, and how to make informed decisions, has the potential to provide broader, more long-lasting protection.</p>
            <p>In earlier work developing and evaluating Informed Health Choices (IHC) resources for primary school students, we have shown that it is feasible to teach critical thinking skills about health actions to children as young as 10-years old.
                <sup>
                    <xref ref-type="bibr" rid="ref15">15</xref>
                </sup>
                <sup>&#x2013;</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref20">20</xref>
                </sup> In that project, we created a framework of principles that are important for people to understand when assessing the reliability of healthcare claims and making informed choices: the IHC Key Concepts.
                <sup>
                    <xref ref-type="bibr" rid="ref21">21</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref22">22</xref>
                </sup> This framework is a starting point for designing curricula, learning resources, and evaluation tools. Focusing on a selection of the IHC Key Concepts, we then developed printed learning resources for primary school children (age 10-12 years) and their teachers
                <sup>
                    <xref ref-type="bibr" rid="ref15">15</xref>
                </sup> and a podcast for parents.
                <sup>
                    <xref ref-type="bibr" rid="ref16">16</xref>
                </sup>
            </p>
            <p>To evaluate the effect of these resources, we conducted two randomised trials in Uganda, one including 120 schools and more than 10,000 children, and another that included 675 parents and guardians of primary school children.
                <sup>
                    <xref ref-type="bibr" rid="ref23">23</xref>
                </sup> The primary outcome measure was responses to multiple-choice questions that measure respondents&#x2019; ability to apply IHC Key Concepts: the Claim Evaluation Tools.
                <sup>
                    <xref ref-type="bibr" rid="ref17">17</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref18">18</xref>
                </sup> The primary school trial demonstrated that use of the resources led to a large improvement in the ability of children and teachers to apply IHC Key Concepts to hypothetical scenarios.
                <sup>
                    <xref ref-type="bibr" rid="ref17">17</xref>
                </sup> The podcast trial showed a smaller, similar effect among parents.
                <sup>
                    <xref ref-type="bibr" rid="ref18">18</xref>
                </sup> Follow-up data showed that children retained their learning for at least one year,
                <sup>
                    <xref ref-type="bibr" rid="ref19">19</xref>
                </sup> while the performance of the parents declined.
                <sup>
                    <xref ref-type="bibr" rid="ref20">20</xref>
                </sup> The primary school resources have been translated into 12 languages and adapted for use in other countries.
                <sup>
                    <xref ref-type="bibr" rid="ref24">24</xref>
                </sup>
            </p>
            <p>Alongside the trials, we undertook process evaluations to explore barriers and facilitators for scaling up use of the learning resources, potential adverse effects, and potential additional benefits.
                <sup>
                    <xref ref-type="bibr" rid="ref25">25</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref26">26</xref>
                </sup> We found that children, teachers, parents, and district education officers valued the IHC primary school resources. The human-centred design approach we employed - iteratively addressing user and stakeholder concerns prior to and during development - was likely an important contributing factor for this positive reception. However, the study pointed to two important implementation barriers in Uganda: printing costs and lack of time in the school schedule.</p>
            <p>Informed by these findings, we began the current five-year project in 2019 to develop and evaluate resources for lower secondary schools (age 13-16) in Kenya, Rwanda, and Uganda. Since drafting this article, we have evaluated the resources in three parallel randomised trials,
                <sup>
                    <xref ref-type="bibr" rid="ref27">27</xref>
                </sup>
                <sup>&#x2013;</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref29">29</xref>
                </sup> are carrying out process evaluations,
                <sup>
                    <xref ref-type="bibr" rid="ref30">30</xref>
                </sup>
                <sup>&#x2013;</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref32">32</xref>
                </sup> and will conduct one-year follow-up trials in each of the three countries.</p>
            <p>This article describes the development of these resources that took place prior to evaluation during the first 2.5 years of the project in two phases. We began development with this set of objectives (see protocol
                <sup>
                    <xref ref-type="bibr" rid="ref33">33</xref>
                </sup>):</p>
            <p>To explore how we might develop resources that are
                <list list-type="bullet">
                    <list-item>
                        <label>&#x2022;</label>
                        <p>Digital (avoiding printing costs)</p>
                    </list-item>
                    <list-item>
                        <label>&#x2022;</label>
                        <p>Suitable for use with schools&#x2019; available digital technology and infrastructure</p>
                    </list-item>
                    <list-item>
                        <label>&#x2022;</label>
                        <p>Compatible with national curricula</p>
                    </list-item>
                    <list-item>
                        <label>&#x2022;</label>
                        <p>Based on evidence about effective strategies for teaching critical thinking</p>
                    </list-item>
                    <list-item>
                        <label>&#x2022;</label>
                        <p>Experienced as accessible, useful, usable, understandable, credible, and desirable by students and teachers, and well-suited to use in their schools</p>
                    </list-item>
                    <list-item>
                        <label>&#x2022;</label>
                        <p>Easily translatable and adaptable to other contexts</p>
                    </list-item>
                    <list-item>
                        <label>&#x2022;</label>
                        <p>Sustainable (i.e., not dependent on our team for rolling out at scale)</p>
                    </list-item>
                </list>
            </p>
            <p>We organised the work in two phases: 1) a set of preliminary studies (involving data documented and discussed elsewhere) and 2) an iterative development phase with data collection and analysis reported in this article. Although the preliminary studies have already been published elsewhere, findings from those studies resulted in reframing of some of our objectives and provided the basis for content and design decisions made in the second phase. Therefore, we describe methods and results from both phases (with references for more detail about phase one). In the discussion, we describe how this study may inform development of similar educational resources for teaching critical thinking.</p>
        </sec>
        <sec id="sec2" sec-type="methods">
            <title>Methods</title>
            <p>We employed perspectives and methods from human-centred design. This is an iterative approach to creating products, systems and services that places users&#x2019; and other stakeholders&#x2019; needs and experiences at the centre of the design process.
                <sup>
                    <xref ref-type="bibr" rid="ref34">34</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref35">35</xref>
                </sup> Early and continued engagement with stakeholder groups and multidisciplinary collaboration are central components of a human-centred design approach.
                <sup>
                    <xref ref-type="bibr" rid="ref36">36</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref37">37</xref>
                </sup> We employed qualitative data collection and analysis methods to explore the user experiences of multiple types of stakeholders for the purpose of informing the development process.</p>
            <p>We established a core team with backgrounds in health systems and public health research, design, journalism, education, social science, statistics, and information and communication technology (ICT). Research leadership was shared among senior team members in East Africa and Norway. Three PhD fellows (one female and two male) based in Kisumu (Kenya), Kigali (Rwanda) and Kampala (Uganda), engaged with stakeholders and collected and analysed data, supported by their local teams including researchers with experience developing and evaluating the IHC primary school resources. All teams contributed to design and content development, led by the team based in Norway who also analysed data. The ICT team, based in Chile, developed the technical solutions.</p>
            <p>We conducted this work in two phases: 1) Groundwork and 2) Development cycles (
                <xref ref-type="fig" rid="f1">Figure 1</xref>). The first phase began in August 2019, the second phase began January 2020 and ended in April 2022.</p>
            <fig fig-type="figure" id="f1" orientation="portrait" position="float">
                <label>Figure 1. </label>
                <caption>
                    <title>Phases of the work.</title>
                </caption>
                <graphic id="gr1" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/163450/71bf09e4-32eb-42d0-a537-3f2560099394_figure1.gif"/>
            </fig>
            <sec id="sec3">
                <title>Identifying and recruiting participating stakeholders</title>
                <p>We defined stakeholders as people or organisations that have a vested interest in the process or results of the study. Intended users &#x2013; secondary school teachers and students &#x2013; were the key stakeholders. Additional stakeholders included curriculum developers and other education policymakers, school administrators, parents, educational researchers, researchers in public or clinical health, and health professionals.</p>
                <p>For the purpose of providing continuous input, we established groups of stakeholders in each country early in the project. We formed teacher networks, recruiting 
                    <italic toggle="yes">via</italic> formal invitation letters to teachers who worked in a mix of government funded and private schools, with varied ICT resources (Uganda), and in rural, semi-rural, and urban environments (Kenya and Rwanda). We formed student networks by asking members of the teacher networks to suggest lower secondary school students who were interested, likely to contribute, and able to participate without adversely affecting their schoolwork, sending them formal invitations and assent forms, and consent forms to parents. Due to Covid-related school closures in parts of Development Cycle 1, we also established &#x201c;home networks&#x201d; of students that we had access to when schools were closed. Home networks included both students that were already recruited to the student network and additional students whom team members could easily reach from nearby communities. We employed convenience sampling and used the same assent forms and consent forms to parents as for the student networks.</p>
                <p>We engaged with the national curriculum development offices to establish channels of contact and collaboration. We formed national advisory panels of policy makers at the ministerial and regional and district levels, school directors, head teachers, leaders of teacher unions, and representatives of parents&#x2019; groups and civil society. We created an international advisory panel of people from 18 countries who had expertise in education, education policy, and relevant areas of research, such as health literacy, evidence-informed decision making, science communication and ICT. Additionally, during the final cycle of development, we recruited seven schools across the three countries to pilot use of the resources in one or more classes over a school semester.</p>
                <p>Apart from people in the international advisory panel, many of whom were a part of our existing professional networks, and some of the students in home networks, we did not have established relationships with the stakeholders prior to the onset of this project.</p>
                <p>Details of how we selected and recruited each stakeholder group and characteristics of participants and schools are described in 
                    <xref ref-type="table" rid="T1">Tables 1</xref>-
                    <xref ref-type="table" rid="T3">3</xref>. More information about the methods, degrees, and nature of engagement with different stakeholders, can be found in a protocol for evaluating stakeholder engagement.
                    <sup>
                        <xref ref-type="bibr" rid="ref38">38</xref>
                    </sup>
                </p>
                <table-wrap id="T1" orientation="portrait" position="float">
                    <label>Table 1. </label>
                    <caption>
                        <title>Participant selection and recruitment methods.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Stakeholder group</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Country</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">What/who we sought</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Sampling/selection</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Method of approach</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Teacher networks</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Kenya, Rwanda, Uganda</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <italic toggle="yes">Schools:</italic> mix of government-funded/private and rural/semi-urban/urban
                                    <break/>
                                    <italic toggle="yes">Teachers:</italic> diverse (gender, level of education, years of experience, subject areas)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Stratified sampling used to select schools, based on school ownership and ICT resources. We contacted head teachers and asked them to suggest one or more teachers to be a part of the network</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">We sent formal invitation letters to teachers</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Student networks (including home networks)</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Kenya, Rwanda, Uganda</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Lower secondary school students who were:
                                    <break/>
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>&#x2010;</label>
                                                <p>interested</p>
                                            </list-item>
                                            <list-item>
                                                <label>&#x2010;</label>
                                                <p>likely to contribute</p>
                                            </list-item>
                                            <list-item>
                                                <label>&#x2010;</label>
                                                <p>able to participate without adversely affecting their schoolwork</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">We asked each member of the teacher networks to suggest one or more students to join student networks in each country, and aimed for a mix of top, average and low academic performers, as well as a mix of gender and age</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">We sent formal invitations to the students and their parents, with consent forms for the parents and assent forms for the students to sign. In some cases, we visited parents at the homes to deliver the letters and explain the study</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>National curriculum developers</bold>
                                </td>
                                <td colspan="1" rowspan="1"/>
                                <td align="left" colspan="1" rowspan="1" valign="top">Members of the national curriculum committees</td>
                                <td colspan="1" rowspan="1"/>
                                <td align="left" colspan="1" rowspan="1" valign="top">We invited them via email, telephone, or face-to-face visits</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>National advisory panels</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Kenya, Rwanda, Uganda</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Policymakers at the ministerial and regional and district levels including curriculum developers, school directors, head teachers, leaders of teacher unions, and representatives of parents&#x2019; groups and civil society</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">We identified potential members by consulting informal contacts, the teacher networks, and initial invitees (snowballing)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">We invited them via email, telephone, or face-to-face visits</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>International advisory panel</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Australia, Brazil, Canada, China, Croatia, Iran, Ireland, Italy, Kenya, Mexico, Norway, Palestine, Rwanda, South Africa, Spain, Uganda, UK, USA, 3ie (international)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">People from low-, middle-, and high-income countries with expertise in education and education policy, relevant areas of research (e.g., education, health literacy, science communication, evidence-based practice, critical thinking), design, ICT, and learning games</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">We identified these through existing contacts, publications, and snowballing</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">We sent invitations via email</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="3" valign="top">
                                    <bold>Pilot schools</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Kenya</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Mix of schools by ownership and geographical: two semi urban public schools one rural public school</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Stratified sampling to select schools by ownership and location. We contacted head teachers and asked them to suggest one or more teachers to be a part of the study</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">We formally introduced the study objectives to ministry of education officials at national, regional and county in Kenya. Together with the officials selected based on selected by ownership and geographical location and contacted the head teachers via formal invitation letters asking their schools to participate in the study</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Rwanda</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Two Schools varied from location (urban/rural), had ICT facilities and were able to dedicate their time in the pilot of learning resources</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Purposively selected them with recommendation from Rwanda Education Board (REB)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">We sent a request to REB and REB requested two schools in a letter addressed to school directors</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Uganda</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Two privately owned schools (rural/urban)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Selected schools in proximity to the research teams. We contacted head teachers and asked them to suggest one or more teachers to participate in the pilot. Then we enrolled the teacher after consenting them</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">We sent formal invitation letters to schools&#x2019; administration (head teachers)</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <table-wrap id="T2" orientation="portrait" position="float">
                    <label>Table 2. </label>
                    <caption>
                        <title>Participant characteristics.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Stakeholder group</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Country</th>
                                <th align="left" colspan="1" rowspan="1" valign="top"># people</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">More detail</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="3" valign="top">
                                    <bold>Teacher networks</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Kenya</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">22 teachers</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <italic toggle="yes">Schools:</italic> 4 urban, 6 semi-urban, 12 rural
                                    <break/>
                                    <italic toggle="yes">Subjects taught:</italic> Business studies, Chemistry, History, Biology, Kiswahili, French, Mathematics, Home-science, CRE, English
                                    <break/>
                                    <italic toggle="yes">Gender:</italic> 12 female, 11 male</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Rwanda</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">19 teachers</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <italic toggle="yes">Schools:</italic> 10 schools (1 private, 5 public and 4 government aided schools).
                                    <break/>
                                    <italic toggle="yes">Teaching experience:</italic> 4 to 10 years.
                                    <break/>
                                    <italic toggle="yes">Subjects taught:</italic> 13 Teachers teach biology. Others teach Chemistry, Physics, Math, French and English.
                                    <break/>
                                    <italic toggle="yes">Gender:</italic> 7 
                                    <styled-content style="#212121" style-type="color">female, 12 male</styled-content>
                                </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Uganda</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">22 teachers</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <italic toggle="yes">Schools:</italic> 5 public schools with at least a projector, 5 private schools with at least a projector, 6 public schools with no projector and 6 private schools with no projector.
                                    <break/>
                                    <italic toggle="yes">Gender:</italic> 7 female, 15 male
                                    <break/>Teaching experience: range was 2-34 years, average of 12 years
                                    <break/>
                                    <italic toggle="yes">Subjects taught</italic>: 7 biology &amp; Chemistry, 7 Maths &amp; Physics, 3 geography &amp; History, 4 English &amp; ICT, 1 Home science</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="3" valign="top">
                                    <bold>Student networks</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Kenya</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">24 students</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <italic toggle="yes">Schools:</italic> 1 public urban, 1 public rural and 1 private urban. 
                                    <italic toggle="yes">Students:</italic> 15&#x2013;18-year-olds, (18 female, 6 male)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Rwanda</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">19 students</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <italic toggle="yes">Schools:</italic> 5 public schools, 4 private schools. 
                                    <italic toggle="yes">Students:</italic> 10&#x2013;16-year-olds
                                    <break/>
                                    <italic toggle="yes">Gender:</italic> 10 female, 9 male</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Uganda</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">21 students</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <italic toggle="yes">Schools:</italic> 1 public with at least a projector, 1 private with at least a projector and 1 private with no projector.
                                    <break/>
                                    <italic toggle="yes">Ages:</italic> 14&#x2013;19-year-olds
                                    <break/>
                                    <italic toggle="yes">Gender:</italic> 13 female, 8 male</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="3" valign="top">
                                    <bold>National curriculum developer office</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Kenya</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1 institute</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Kenya Institute of Curriculum Development (KICD)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Rwanda</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1 institute</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Rwanda Basic Education Board (REB)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Uganda</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1 institute</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">National Curriculum Development Centre (NCDC)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="3" valign="top">
                                    <bold>National advisory groups</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Kenya</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">12</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Researchers and practitioners from various fields (education, health, design/IT), curriculum specialists and teachers)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Rwanda</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">11</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1 curriculum developer, 1 ICT specialist, 3 from health sector (adolescent, community health and health services), 1 educational researcher and 5 educational development partners working in Rwanda</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Uganda</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">14</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Curriculum developers, Policy makers (commissioners, district education officers) from government, school head teachers, teachers, education researchers</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>International advisory group</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">18 countries: Australia, Brazil, Canada, China, Croatia, Iran, Ireland, Italy, Kenya, Mexico, Norway, Palestine, Rwanda, South Africa, Spain, Uganda, UK, USA</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">56 people</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Researchers and practitioners from various fields: education, public and clinical health, health literacy, design/IT/games, methodologists, and funders/international organisations</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <table-wrap id="T3" orientation="portrait" position="float">
                    <label>Table 3. </label>
                    <caption>
                        <title>Characteristics of schools participating in pilot of ten lessons.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Country</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Number and type of schools</th>
                                <th align="left" colspan="1" rowspan="1" valign="top"># of classes/groups</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Class level</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Total # of students</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Kenya</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2 public semi urban and 1 public- rural</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">5 classes</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Form one (Students that are equivalent in age to Rwanda and Uganda &#x201c;senior two in ordinary level&#x201d;, approx. 13-15 years old)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Approximately 200 students</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Rwanda</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1 public/rural/and day school and 1 government aided/urban/and day school</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2 classes</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Senior two in ordinary level</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">84 students</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Uganda</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2 private schools (one with a projector and the other without)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2 groups (conducted on school premises during a period of school closure due to Covid)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Senior two in ordinary level</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">23 students</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
            </sec>
            <sec id="sec4">
                <title>Phase 1: Groundwork</title>
                <p>The groundwork phase consisted of a series of preliminary studies. More detail about the methods and results can be found in separate publications (see overview in 
                    <xref ref-type="table" rid="T4">Table 4</xref>).</p>
                <table-wrap id="T4" orientation="portrait" position="float">
                    <label>Table 4. </label>
                    <caption>
                        <title>Overview of preliminary studies.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Study aim</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Methods/Study design</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Data sources</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">More detail</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Analysing contexts in Kenya, Rwanda, and Uganda</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Individual and group interviews, document analysis, non-participatory observation</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <italic toggle="yes">Interviews:</italic> Teachers, students, curriculum developers, ICT support staff
                                    <break/>
                                    <italic toggle="yes">Document analysis:</italic> learning materials for health and science subjects, curriculum documents, ICT policy documents
                                    <break/>
                                    <italic toggle="yes">Observation</italic>: School classes</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <sup>
                                        <xref ref-type="bibr" rid="ref39">39</xref>
                                    </sup>
                                    <sup>&#x2013;</sup>
                                    <sup>
                                        <xref ref-type="bibr" rid="ref41">41</xref>
                                    </sup>
                                </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Prioritising IHC Key Concepts (learning goals)</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Iterative, structured consensus process</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Curriculum specialists, teachers, and researchers</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <sup>
                                        <xref ref-type="bibr" rid="ref54">54</xref>
                                    </sup>
                                </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Identifying teaching strategies for critical thinking</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Overview of systematic reviews</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Systematic reviews of the effects of teaching strategies for critical thinking</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <sup>
                                        <xref ref-type="bibr" rid="ref44">44</xref>
                                    </sup>
                                </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Collecting examples</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Individual and group interviews</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Secondary school students in Kenya, Rwanda, and Uganda</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <sup>
                                        <xref ref-type="bibr" rid="ref45">45</xref>
                                    </sup>
                                </td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <p>
                    <bold>Analysing contexts</bold>
                </p>
                <p>To inform the development of the resources, as well as their potential implementation in Kenya, Rwanda and Uganda lower secondary schools, we explored if there was demand for learning resources to teach critical thinking; if such resources were in use; how the content maps onto existing curricula; what administrative approval was necessary; what ICT infrastructure is available in schools and how it is used in schools. We analysed the three country contexts. Detailed methods are reported in a separate publication.
                    <sup>
                        <xref ref-type="bibr" rid="ref39">39</xref>
                    </sup>
                    <sup>&#x2013;</sup>
                    <sup>
                        <xref ref-type="bibr" rid="ref41">41</xref>
                    </sup>
                </p>
                <p>To synthesize findings from these studies in a way that was useful for developing educational resources, we drew on the behaviour change wheel.
                    <sup>
                        <xref ref-type="bibr" rid="ref42">42</xref>
                    </sup> This is a framework for characterising and designing interventions for behaviour change, built around three essential conditions for change: Capability, Opportunity, and Motivation (the COM-B system). We organised findings from the three context analyses according to these three themes. The synthesized findings from these three context analyses supplemented our original set of development aims and provided a much more detailed understanding of contextual challenges before we started the development phase.</p>
                <p>
                    <bold>Prioritising IHC Key Concepts</bold>
                </p>
                <p>Due to the scope of our research funding, as well as the pandemic and school closures, we could not pilot and evaluate resources that took longer to use than one school semester. To prioritise which of the 49 IHC Key Concepts to include in the learning goals for the resources, we organised a structured, iterative consensus process with curriculum specialists, teachers, and researchers. Detailed methods are reported in a separate publication.
                    <sup>
                        <xref ref-type="bibr" rid="ref43">43</xref>
                    </sup>
                </p>
                <p>
                    <bold>Identifying teaching strategies</bold>
                </p>
                <p>To identify effective, relevant teaching strategies to inform the resources, we conducted an overview of systematic reviews of strategies for teaching critical thinking. Detailed methods are reported in a separate protocol.
                    <sup>
                        <xref ref-type="bibr" rid="ref44">44</xref>
                    </sup>
                </p>
                <p>
                    <bold>Collecting examples</bold>
                </p>
                <p>To identify relevant and engaging examples for the resources, we interviewed Kenyan, Rwandan, and Ugandan secondary school students (aged 14 to 16) from the student networks, via WhatsApp. We collected examples of health actions, their claimed and actual effects, and information sources. The students rated their interest in a broad range of health actions and conditions, and we used those with higher scores as examples in the resources. Detailed methods are reported in an online report.
                    <sup>
                        <xref ref-type="bibr" rid="ref45">45</xref>
                    </sup>
                </p>
            </sec>
            <sec id="sec5">
                <title>Phase 2: Development cycles</title>
                <p>Starting with what we learned and developed in the preliminary studies, we developed resources in three iterative cycles of content creation and feedback. Each development cycle (
                    <xref ref-type="fig" rid="f2">Figure 2</xref>) included:
                    <list list-type="bullet">
                        <list-item>
                            <label>-</label>
                            <p>Generating ideas</p>
                        </list-item>
                        <list-item>
                            <label>-</label>
                            <p>Prototyping</p>
                        </list-item>
                        <list-item>
                            <label>-</label>
                            <p>Pilot testing prototypes and collecting data</p>
                        </list-item>
                        <list-item>
                            <label>-</label>
                            <p>Analysing problems</p>
                        </list-item>
                        <list-item>
                            <label>-</label>
                            <p>Checking our analysis of the most important problems and solution ideas with key stakeholders, drawing on the concept of &#x201c;member checking&#x201d;
                                <sup>
                                    <xref ref-type="bibr" rid="ref46">46</xref>
                                </sup>
                            </p>
                        </list-item>
                    </list>
                </p>
                <fig fig-type="figure" id="f2" orientation="portrait" position="float">
                    <label>Figure 2. </label>
                    <caption>
                        <title>Single development cycle.</title>
                    </caption>
                    <graphic id="gr2" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/163450/71bf09e4-32eb-42d0-a537-3f2560099394_figure2.gif"/>
                </fig>
                <p>We also sought 
                    <italic toggle="yes">ad hoc</italic> feedback from the student and teacher networks as needed.</p>
                <p>
                    <bold>Generating ideas</bold>
                </p>
                <p>We generated content and design ideas in two ways: brainstorming
                    <sup>
                        <xref ref-type="bibr" rid="ref33">33</xref>
                    </sup> internally, within the team; and identifying ideas suggested in external feedback, from participating stakeholders.
                    <sup>
                        <xref ref-type="bibr" rid="ref47">47</xref>
                    </sup> We selected ideas based on considerations such as consistency with what teachers and students said they valued, and ease of implementation.</p>
                <p>
                    <bold>Prototyping</bold>
                </p>
                <p>A prototype is a sketch or model. We developed increasingly refined prototypes in each cycle. We used the platforms 
                    <ext-link ext-link-type="uri" xlink:href="https://www.google.com/drive/">Google Drive</ext-link> (including 
                    <ext-link ext-link-type="uri" xlink:href="https://www.google.com/docs/about/">Google Docs</ext-link> and 
                    <ext-link ext-link-type="uri" xlink:href="https://www.google.com/slides/about/">Google Slides</ext-link>) and 
                    <ext-link ext-link-type="uri" xlink:href="https://helpx.adobe.com/xd/get-started.html">Adobe XD</ext-link> for drafting, editing, and sketching. We drafted and edited text using Google Docs, exported early prototypes to PDF format, and used Google Slides and Adobe XD later to create interactive sketches. Final versions were published as 
                    <ext-link ext-link-type="uri" xlink:href="https://besmarthealth.org/">web pages</ext-link>, using Google Drive as a content editing platform.</p>
                <p>
                    <bold>Testing prototypes and collecting data</bold>
                </p>
                <p>The three PhD fellows conducted interviews in their respective settings, supported by their research assistants. They had university degrees (Bachelor of Statistics, Master of Epidemiology &amp; Biostatistics, Master of Public Health, and Master of Community Health and Development) and have attended PhD-level courses in qualitative study methods.</p>
                <p>
                    <bold>
                        <italic toggle="yes">Individual interviews employing user testing methods</italic>
                    </bold>
                </p>
                <p>Using semi-structured guides
                    <sup>
                        <xref ref-type="bibr" rid="ref48">48</xref>
                    </sup> that were pilot tested, the three PhD fellows conducted user test with individual teachers and students, to explore how they experienced prototypes and how we might make improvements. Data were collected face to face or online when covid measures restricted face to face meetings. When possible, user testing immediately followed a pilot lesson, so the participant had their experiences from the lesson fresh in mind. Interview duration was approximately one hour. Occasionally, teams printed the digital prototypes on paper to collect feedback where there was no access to a device or internet connection.</p>
                <p>Each user testing session had three main parts. First, interviewers introduced themselves and the reasons for the interview. Next, they employed a think-aloud approach: a method of qualitative data collection that encourages the participant to articulate their thoughts while performing a task,
                    <sup>
                        <xref ref-type="bibr" rid="ref49">49</xref>
                    </sup>
                    <sup>&#x2013;</sup>
                    <sup>
                        <xref ref-type="bibr" rid="ref51">51</xref>
                    </sup> in this case reviewing prototypes of the resources. The last part was conducted as a semi-structured interview.</p>
                <p>We captured data as observers&#x2019; notes and audio recordings. We designed the interview guides to explore different facets of the user experience, including usefulness, understandability, usability, credibility, desirability, and identification, based on a revised version of Morville&#x2019;s framework of user experience (
                    <xref ref-type="table" rid="T5">Table 5</xref>).
                    <sup>
                        <xref ref-type="bibr" rid="ref34">34</xref>
                    </sup>
                </p>
                <table-wrap id="T5" orientation="portrait" position="float">
                    <label>Table 5. </label>
                    <caption>
                        <title>Revised version of Morville&#x2019;s framework of user experience.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Facet</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Description</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Usefulness</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Does this product have practical value for the user?</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Usability</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">How easy and satisfying is this product to use?</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Understandability</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Does the user recognize what the product is, and do they understand the content? (Subjective experience of understanding)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Credibility</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Is the content trustworthy?</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Desirability</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Is this product something the user wants &#x2013; has a positive emotional response to?</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Identification</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Does the user feel the product is for &#x201c;someone like me&#x201d; or is it alienating/foreign-feeling? (e.g., age, gender, culture&#x2013;appropriate)</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <p>
                    <bold>
                        <italic toggle="yes">Group interviews</italic>
                    </bold>
                </p>
                <p>The PhD fellows conducted semi-structured interviews with groups of students or teachers to explore their experiences of the prototypes, using pilot-tested interview guides.
                    <sup>
                        <xref ref-type="bibr" rid="ref48">48</xref>
                    </sup> When possible, interviews were scheduled immediately after a pilot lesson when the participants had their experiences fresh in mind. Sessions lasted approximately one hour.</p>
                <p>We chose group interviews, rather than user testing or individual interviews, when we anticipated that the former would improve the quality of the data, for instance by increasing students&#x2019; confidence in speaking with researchers. Group interviews took place at schools or other locations determined to be practical for the participants. After introducing themselves and explaining reasons for the interview, one researcher moderated and one or more researchers observed and took notes. Sometimes, teachers were present during student interviews. With written informed consent (from parents and teachers) and assent (from students), we audio-recorded sessions.</p>
                <p>
                    <bold>
                        <italic toggle="yes">Piloting and observation</italic>
                    </bold>
                </p>
                <p>We facilitated pilots of the prototypes to explore how teachers and students used and experienced them in as natural settings as possible. Early pilots involved single lessons, with one of the PhD fellows sometimes assuming the role of the teacher. These took place both at schools and in other settings, such as students&#x2019; neighbourhoods, when schools were closed due to the pandemic. In the final pilot, teachers taught all the lessons over a school term, with access to a complete prototype of the resources including the teacher&#x2019;s guide. (In Uganda, although schools were still closed, we got permission for students from the student network and teachers to meet at the schools for the purpose of conducting pilot lessons.) PhD fellows or research assistants observed and took notes using a structured guide,
                    <sup>
                        <xref ref-type="bibr" rid="ref48">48</xref>
                    </sup> without intervening. We followed up pilots with either individual or group interviews.</p>
                <p>
                    <bold>
                        <italic toggle="yes">&#x201c;Critical Thinking about Health&#x201d; Test</italic>
                    </bold>
                </p>
                <p>After piloting a full set of lessons, students took the &#x201c;Critical Thinking about Health&#x201d; Test.
                    <sup>
                        <xref ref-type="bibr" rid="ref52">52</xref>
                    </sup> Administering the test had two purposes: validating the items included in the test and giving us a sense of whether the prototypes had the intended effects. We report the validation in detail in a separate article.
                    <sup>
                        <xref ref-type="bibr" rid="ref52">52</xref>
                    </sup>
                </p>
                <p>
                    <bold>
                        <italic toggle="yes">Consulting the advisory groups</italic>
                    </bold>
                </p>
                <p>Twice annually, we emailed the international advisory group, to update them on the project, and ask for feedback on specific parts or prototypes. We entered their feedback in a spreadsheet,
                    <sup>
                        <xref ref-type="bibr" rid="ref47">47</xref>
                    </sup> familiarised ourselves with those data, and discussed and agreed on how to deal with any specific suggestions. We held face-to-face meetings with the national advisory groups to keep them updated and seek feedback related to ensuring the sustainability and future scaling up of resources, if shown to be effective.</p>
                <p>
                    <bold>Data analysis</bold>
                </p>
                <p>In Uganda and Kenya, all interviews were carried out in English and transcribed. In Rwanda, interviews were carried out in Kinyarwanda and transcribed in English. There, the PhD fellow and research assistant relied on notes they made during interview sessions, and selected some recordings to review when further clarification of their notes was needed. The three PhD fellows and their three research assistants reviewed transcriptions, their own interview and observation notes, and recordings, and extracted data about negative and positive experiences. They entered the data into 
                    <ext-link ext-link-type="uri" xlink:href="https://www.microsoft.com/en-gb/microsoft-365/excel">Excel</ext-link> spreadsheets,
                    <sup>
                        <xref ref-type="bibr" rid="ref47">47</xref>
                    </sup> supplemented with quotations where relevant, and tagged the data using pre-determined codes related to the nature of an experience (e.g., &#x201c;negative&#x201d;); the &#x201c;location&#x201d; of the experience, i.e., the relevant part of the resources (e.g., &#x201c;illustration/graphics&#x201d;), and suggested implication (e.g., &#x201c;consider changes&#x201d;). We did not anticipate differences in results between male and female students, so coding did not include gender identification. The prototyping team reviewed the coded data, flagged data entries that they did not understand, suggested changes to codes, and discussed the suggestions with the PhD fellows and their research assistants.</p>
                <p>After agreeing with the original coders on the final codes, the three-person prototyping team sorted data entries according to the nature, implication and location, and re-reviewed them, focusing on data tagged with the implication &#x201c;showstopper&#x201d; or &#x201c;consider changes&#x201d;. New topic codes emerged during this process and were added as thematic labels of issues that needed addressing (
                    <italic toggle="yes">e.g.,</italic> &#x201c;Time&#x201d;, &#x201c;Conceptual misunderstanding&#x201d;, &#x201c;student-computer mode&#x201d;). This coding scheme evolved throughout. For an example from the dataset,
                    <sup>
                        <xref ref-type="bibr" rid="ref47">47</xref>
                    </sup> see the &#x201c;Topics&#x201d; column in the 
                    <ext-link ext-link-type="uri" xlink:href="https://zenodo.org/record/7695783/files/DevelopmentCycle2_codes%20and%20response%20options.csv?download=1">Development Cycle 2 &#x2013; codes and response options</ext-link>. When data analysis raised important unanswered questions or resulted disagreement about interpretation, the team either contacted teacher or student networks for additional input, or adjusted interview guides to include these issues in the next development cycle.</p>
                <p>The prototyping team drafted a description and assessment of the most important problems with the prototypes, with an initial set of ideas for solutions. The whole project team discussed these drafts, reached a consensus about which were the most important problems and brainstormed additional ideas for solutions. Based on this input, the prototyping team made the final decision about which solutions to implement.</p>
                <p>
                    <bold>Checking with stakeholders</bold>
                </p>
                <p>Drawing on the method &#x201c;member checking&#x201d;,
                    <sup>
                        <xref ref-type="bibr" rid="ref46">46</xref>
                    </sup> we carried out &#x201c;stakeholder checking&#x201d;, checking our analysis and ideas with the teacher networks and curriculum developers. At the end of each development cycle, we presented descriptions of what we considered the most important problems and our proposed solutions. We asked about the accuracy of the analysis, their reactions to the proposed solutions, and any suggestions of their own. We modified solutions based on this input.</p>
                <p>
                    <bold>
                        <italic toggle="yes">Ad hoc</italic> feedback</bold>
                </p>
                <p>At different points within each development cycle, we also contacted people in the teacher and student networks for quick feedback on specific issues, for instance what to call the resources.</p>
                <p>
                    <xref ref-type="fig" rid="f3">Figure 3</xref> and 
                    <xref ref-type="table" rid="T6">Table 6</xref> provide an overview of what we did in the three development cycles.</p>
                <fig fig-type="figure" id="f3" orientation="portrait" position="float">
                    <label>Figure 3. </label>
                    <caption>
                        <title>Overview of the three development cycles.</title>
                    </caption>
                    <graphic id="gr3" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/163450/71bf09e4-32eb-42d0-a537-3f2560099394_figure3.gif"/>
                </fig>
                <table-wrap id="T6" orientation="portrait" position="float">
                    <label>Table 6. </label>
                    <caption>
                        <title>Scope of teacher and student data collection (interviews, lesson pilots, tests).</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Method</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Development cycle 1</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Development cycle 2</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Student interviews</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>18 interviews</bold> (11 individual user tests and 7 group interviews)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>17 interviews</bold> (2 individual user tests and 15 group interviews)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Teacher interviews</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>23 interviews</bold> (19 individual user tests of which 8 took place after teachers taught a lesson, and 4 group interviews of which 4 took place after teachers taught a lesson)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>35 interviews</bold> (33 individual user test interviews of which 9 took place after teachers taught a lesson, and 2 group interviews of which 2 took place after teachers taught a lesson)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="3" valign="top">
                                    <bold>Piloting lessons and test</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Our team observed 4 pilot lessons</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>9 classes piloted the full set of 10 lessons</bold>
                                </td>
                            </tr>
                            <tr>
                                <td colspan="1" rowspan="2"/>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Our team observed 37 pilot lessons</bold>
                                </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>259 students</bold> took &#x201c;Critical Thinking about Health&#x201d; test</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
            </sec>
            <sec id="sec6">
                <title>Ethics approval</title>
                <p>We obtained ethics approval for the entire project from local institutional review boards and national research governing councils in Kenya, Rwanda, and Uganda: the Rwanda National Ethics Committee (approval number 916/RNEC/2019); Masinde Muliro University of Science and Technology Institutional Ethics Review Committee and the Kenyan National Commission for Science, Technology and Innovation (approval number NACOSTI/P119/1986); and Makerere University School of Medicine Research Ethics Committee (REC REF 2020-139) and Uganda National Council of Science and Technology (HS916ES).</p>
            </sec>
        </sec>
        <sec id="sec7" sec-type="results">
            <title>Results</title>
            <p>We present two different types of results that emerged from this work: the designed output (final version of the resources), and the knowledge output that informed our development (findings from Phase 1 and 2). We report the designed output first, to give the reader an overview of the resource features and components we refer to in the findings.</p>
            <sec id="sec8">
                <title>Designed output: the final version of &#x201c;Be smart about your health&#x201d; resources</title>
                <p>The final set of resources, 
                    <ext-link ext-link-type="uri" xlink:href="https://besmarthealth.org/">Be smart about your health</ext-link>, is an open access website for teachers comprised of ten lesson plans, a teachers&#x2019; guide, and extra resources including materials for teacher training.
                    <sup>
                        <xref ref-type="bibr" rid="ref53">53</xref>
                    </sup> Lesson plans are designed in two modes: for use in classrooms with a blackboard/flipchart (optimized for smartphone) and for classrooms with a projector with lessons formatted as downloadable Google Slides presentations. See 
                    <xref ref-type="table" rid="T7">Table 7</xref> and 
                    <xref ref-type="fig" rid="f4">Figures 4</xref>&#x2013;
                    <xref ref-type="fig" rid="f9">9</xref>.</p>
                <table-wrap id="T7" orientation="portrait" position="float">
                    <label>Table 7. </label>
                    <caption>
                        <title>Final list of ten 40-minute lesson plans.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Lesson title</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Description</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Lesson 1: Health actions</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Health actions, and why it is important to think carefully about them</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Lesson 2: Health claims</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Recognising claims about the effects of health actions</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Lesson 3: Unreliable claims</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Identifying some common types of unreliable claims</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Lesson 4: Reliable claims</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Identifying more reliable claims by considering whether the claim is based on a comparison of health actions</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Lesson 5: Using what we learned</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">A review of the first four lessons, applying what has been learned to daily life, and recognising its limits</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Lesson 6: Randomly-created groups</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Assessing the reliability of comparisons by considering one important feature of reliable comparisons: randomly-created groups</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Lesson 7: Large-enough groups</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Continuing to assess the reliability of comparisons by considering whether the groups are large enough</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Lesson 8: Personal choices</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Thinking critically to make smart personal choices about health actions</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Lesson 9: Community choices</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Thinking critically to make smart community health choices</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Lesson 10: Using what we learned</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">A review of all nine lessons, applying what has been learned to daily life, and recognising its limits</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <fig fig-type="figure" id="f4" orientation="portrait" position="float">
                    <label>Figure 4. </label>
                    <caption>
                        <title>Final version of the &#x201c;Be smart about your health&#x201d; resources.</title>
                        <p>Contents include 
                            <italic toggle="yes">Teachers&#x2019; guide</italic>, 
                            <italic toggle="yes">Blackboard lesson plans, Projector lesson plans</italic>, and 
                            <italic toggle="yes">Extra resources.</italic>
                        </p>
                    </caption>
                    <graphic id="gr4" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/163450/71bf09e4-32eb-42d0-a537-3f2560099394_figure4.gif"/>
                </fig>
                <fig fig-type="figure" id="f5" orientation="portrait" position="float">
                    <label>Figure 5. </label>
                    <caption>
                        <title>Lessons designed in two modes: 
                            <italic toggle="yes">Blackboard mode</italic> for use in classrooms equipped with a blackboard or a flipboard, and 
                            <italic toggle="yes">Projector mode</italic> for use in classrooms with a projector.</title>
                    </caption>
                    <graphic id="gr5" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/163450/71bf09e4-32eb-42d0-a537-3f2560099394_figure5.gif"/>
                </fig>
                <fig fig-type="figure" id="f6" orientation="portrait" position="float">
                    <label>Figure 6. </label>
                    <caption>
                        <title>Lesson plan content.</title>
                        <p>Each lesson plan includes an 
                            <italic toggle="yes">Overview</italic>, 
                            <italic toggle="yes">Lesson</italic>, and 
                            <italic toggle="yes">Background</italic> section for teachers. Each 
                            <italic toggle="yes">Lesson</italic> has three parts: Introduction, Activity, and Wrap-up.</p>
                    </caption>
                    <graphic id="gr6" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/163450/71bf09e4-32eb-42d0-a537-3f2560099394_figure6.gif"/>
                </fig>
                <fig fig-type="figure" id="f7" orientation="portrait" position="float">
                    <label>Figure 7. </label>
                    <caption>
                        <title>Teachers&#x2019; guide includes: Introduction, Overview of the lessons, Using the resources, Background for teachers, Development and evaluation, and Other relevant resources.</title>
                    </caption>
                    <graphic id="gr7" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/163450/71bf09e4-32eb-42d0-a537-3f2560099394_figure7.gif"/>
                </fig>
                <fig fig-type="figure" id="f8" orientation="portrait" position="float">
                    <label>Figure 8. </label>
                    <caption>
                        <title>Teacher training materials.</title>
                    </caption>
                    <graphic id="gr8" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/163450/71bf09e4-32eb-42d0-a537-3f2560099394_figure8.gif"/>
                </fig>
                <fig fig-type="figure" id="f9" orientation="portrait" position="float">
                    <label>Figure 9. </label>
                    <caption>
                        <title>The examples collection provides alternative health actions or health problems/goals for each lesson or Key Concept in the resources.</title>
                    </caption>
                    <graphic id="gr9" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/163450/71bf09e4-32eb-42d0-a537-3f2560099394_figure9.gif"/>
                </fig>
                <p>
                    <bold>
                        <italic toggle="yes">Lessons plans:</italic>
                    </bold>
                    <list list-type="bullet">
                        <list-item>
                            <label>-</label>
                            <p>
                                <italic toggle="yes">Content:</italic> Set of ten lesson plans, two of which are for review and applying what students learned to their daily lives (
                                <xref ref-type="table" rid="T7">Table 7</xref>)</p>
                        </list-item>
                        <list-item>
                            <label>-</label>
                            <p>
                                <italic toggle="yes">Structure:</italic> Each Lesson Plan has an Overview, Lesson, and Background section. Each Lesson is designed to be taught in 40 minutes, and has three parts: Introduction, Activity, and Wrap-up (
                                <xref ref-type="fig" rid="f5">Figure 5</xref>)</p>
                        </list-item>
                        <list-item>
                            <label>-</label>
                            <p>
                                <italic toggle="yes">Format:</italic> To accommodate for varied ICT infrastructure in schools, we created two modes of resources for teachers to deliver lessons: Blackboard lesson plans and Projector lesson plans. Blackboard lesson plans are optimised for teachers on mobile devices and work also offline. These can also serve as a back-up in the event of electricity outages. Projector mode is for use in classrooms that have access to a projector. We also created sets of optional, downloadable printouts for teachers to use as a paper back-up (
                                <xref ref-type="fig" rid="f6">Figure 6</xref>)</p>
                        </list-item>
                    </list>
                </p>
                <p>
                    <bold>
                        <italic toggle="yes">Teachers&#x2019; guide</italic>
                    </bold>: This includes an introduction to why the learning goals are important, a description of the content and how it ties to the curriculum in Kenya, Rwanda and Uganda, how to navigate the resources, how they were developed, and where to find other relevant resources (
                    <xref ref-type="fig" rid="f7">Figure 7</xref>).</p>
                <p>
                    <bold>
                        <italic toggle="yes">Extra resources</italic>
                    </bold>:
                    <list list-type="bullet">
                        <list-item>
                            <label>-</label>
                            <p>Teacher training materials, designed to be taught in workshops by teachers who participated in pilots (
                                <xref ref-type="fig" rid="f8">Figure 8</xref>)</p>
                        </list-item>
                        <list-item>
                            <label>-</label>
                            <p>Glossary</p>
                        </list-item>
                        <list-item>
                            <label>-</label>
                            <p>Examples collection (alternative examples of health actions for each lesson) (
                                <xref ref-type="fig" rid="f9">Figure 9</xref>)</p>
                        </list-item>
                        <list-item>
                            <label>-</label>
                            <p>Teaching strategies for teaching critical thinking</p>
                        </list-item>
                        <list-item>
                            <label>-</label>
                            <p>Underlying principles</p>
                        </list-item>
                    </list>
                </p>
            </sec>
            <sec id="sec9">
                <title>Findings from Phase 1: Groundwork</title>
                <p>Below we describe output from the preliminary studies in Phase 1. As explained earlier, data from these studies have already been reported and discussed in other publications. However, for the reader to understand the full development process, and how these results influenced our objectives, content, and design, they are summarised below.</p>
                <p>
                    <bold>Analysing contexts</bold>
                </p>
                <p>We organised key findings from the context analyses in four themes: 
                    <italic toggle="yes">motivation</italic> to teach or learn the content; 
                    <italic toggle="yes">capability</italic> to teach the content; 
                    <italic toggle="yes">capability</italic> to use digital resources; and 
                    <italic toggle="yes">opportunity</italic> to teach the content within existing curricula using digital resources.
                    <sup>
                        <xref ref-type="bibr" rid="ref39">39</xref>
                    </sup>
                    <sup>&#x2013;</sup>
                    <sup>
                        <xref ref-type="bibr" rid="ref42">42</xref>
                    </sup> Based on these findings, we identified opportunities and challenges, and made decisions about how to resolve those.</p>
                <p>Stakeholders considered it to be important for students to learn to think critically about health, and the curricula included related learning goals. But teachers lacked capabilities and opportunities to teach both critical thinking in general, and about health choices more specifically. Additionally, schools&#x2019; digital infrastructures ranged from fully equipped with student computer labs to schools with few devices and no internet. Some of the strategies we decided to use included creating a teacher&#x2019;s guide with in-depth background content and providing extra information about teaching strategies for critical thinking. We created lessons in different modes, with offline functionality to accommodate for variation in access to computers or digital infrastructure. See 
                    <xref ref-type="table" rid="T8">Table 8</xref> for more detail about these findings and our solutions.</p>
                <table-wrap id="T8" orientation="portrait" position="float">
                    <label>Table 8. </label>
                    <caption>
                        <title>Synthesis from context analyses and solutions.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Theme</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Opportunities and challenges</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Solutions</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Motivation to teach or learn the content</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Curricula in Kenya, Rwanda and Uganda included learning goals related to &#x2018;critical thinking&#x2019; as a generic competence and to &#x2018;health&#x2019;, but none related specifically to &#x2018;critical thinking about health&#x2019;.
                                    <break/>Curriculum developers, teachers, and students said it was important for students to learn to think critically about health information and choices. However, teaching was largely exam-focused, so teachers and students were unlikely to prioritise content not included in exams.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">In the teachers&#x2019; guide, we included descriptions of how the content mapped onto each country&#x2019;s national curriculum.
                                    <break/>We communicated regularly with curriculum development offices to facilitate alignment with curricula, ownership of the resources, and future uptake of them.</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="2" valign="top">
                                    <bold>Capability to teach the content</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Teachers lacked prior knowledge of the IHC Key Concepts.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">We created a teachers&#x2019; guide with an introduction and more detail about the IHC Key Concepts.
                                    <break/>In each lesson plan, we created a detailed background section describing the respective IHC Key Concepts for that lesson.</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Teacher said they lacked experience teaching and evaluating critical thinking in general. We did not identify any existing resources in use for learning or teaching critical thinking.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">We created lessons drawing on teaching strategies for critical thinking that we identified in our overview of systematic reviews and included descriptions of these in lesson plans and Extra resources.</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="4" valign="top">
                                    <bold>Capability to use digital resources</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="4" valign="top">Teachers had varied experience using ICT for teaching. Many lacked ICT training.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">To facilitate ease of access we developed open-access web-based resources. The design is responsive, therefore suitable for any screen size.</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">To increase ease of use, we dropped log-in functionality and simplified the interface as much as possible. We used large font sizes, consistent formatting, and minimized amount of texts to facilitate ease of use during teaching.</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">In the teachers&#x2019; guide, we included a help section explaining the navigation and technical features of the site.</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">We created sets of optional, downloadable printouts for each lesson for teachers who preferred or had the opportunity of making paper copies.</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="3" valign="top">
                                    <bold>Opportunity to teach the content within existing curricula using digital resources</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">We identified subjects in the Kenyan, Rwandan, and Ugandan curricula where the IHC Key Concepts could fit in the event of future uptake.
                                    <break/>Curriculum development offices would need to approve the use of any new teaching resource. Resources must be possible to download, adapt and republish on national platforms.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">To facilitate tailored implementation, we created an adaptable, translatable solution using Google drive as an editing platform. Curriculum development offices can install their own versions of the resources for future translations or adaptations.</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="2" valign="top">Schools had very different levels of access to ICT infrastructure for teaching and learning, ranging from almost no access to well-equipped computer labs. About half of Rwandan secondary schools have &#x201c;smart classrooms&#x201d;: computer labs with laptops and Internet access. Poor Internet connectivity and unstable electricity were persistent barriers to use of digital resources in many schools, in all three countries.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">To accommodate for varied access to ICT across schools, we created resources for delivering lessons in three different modes: Blackboard, Projector, and Student-computer modes.
                                    <break/>Blackboard lesson plans were optimised for teachers on mobile devices. These could also serve as a back-up in the event of electricity outages. Projector lesson plans included downloadable lessons formatted as Google Slides presentations. We also created sets of optional, downloadable printouts.
                                    <break/>Student-computer mode were designed for computer lab classrooms, with interactive lessons for students to use individually or in groups, in a class led by a teacher. (We later deactivated this mode, see results from development cycles below.)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">To accommodate users with a poor Internet connection, we built in offline functionality: when the user visits a page online, an automatic download begins, with messages and icons alerting the user. We also created a cached version that loads faster, for slow Internet connections.</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <p>
                    <bold>Prioritising IHC Key Concepts</bold>
                </p>
                <p>Twelve curriculum specialists, teachers, and researchers, in Kenya, Rwanda, and Uganda prioritised nine of the IHC Key Concepts (
                    <xref ref-type="boxed-text" rid="B1">Box 1</xref>) as suitable, relevant, and important for lower-secondary school students.
                    <sup>
                        <xref ref-type="bibr" rid="ref54">54</xref>
                    </sup> These nine concepts formed the basis for the learning goals and subsequent content development.</p>
                <boxed-text id="B1" orientation="portrait" position="float">
                    <label>Box 1. </label>
                    <caption>
                        <title>Nine prioritised IHC Key Concepts.</title>
                    </caption>
                    <p>
                        <list list-type="bullet">
                            <list-item>
                                <label>&#x2022;</label>
                                <p>Treatments can cause harms as well as benefits.</p>
                            </list-item>
                            <list-item>
                                <label>&#x2022;</label>
                                <p>Widely used treatments or those that have been used for a long time are not necessarily beneficial or safe.</p>
                            </list-item>
                            <list-item>
                                <label>&#x2022;</label>
                                <p>Treatments that are new or technologically impressive may not be better than available alternatives.</p>
                            </list-item>
                            <list-item>
                                <label>&#x2022;</label>
                                <p>Personal experiences or anecdotes alone are an unreliable basis for most claims.</p>
                            </list-item>
                            <list-item>
                                <label>&#x2022;</label>
                                <p>Identifying effects of treatments depends on making comparisons.</p>
                            </list-item>
                            <list-item>
                                <label>&#x2022;</label>
                                <p>Comparison groups should be as similar as possible.</p>
                            </list-item>
                            <list-item>
                                <label>&#x2022;</label>
                                <p>Small studies may be misleading.</p>
                            </list-item>
                            <list-item>
                                <label>&#x2022;</label>
                                <p>Large, dramatic effects are rare.</p>
                            </list-item>
                            <list-item>
                                <label>&#x2022;</label>
                                <p>Weigh the benefits and savings against the harms and costs of acting or not.</p>
                            </list-item>
                        </list>
                    </p>
                </boxed-text>
                <p>
                    <bold>Identifying teaching strategies</bold>
                </p>
                <p>In an overview of systematic reviews, we identified teaching strategies for helping primary and secondary school students learn to think critically.
                    <sup>
                        <xref ref-type="bibr" rid="ref44">44</xref>
                    </sup> We experimented with using different strategies in each lesson, but found it added too much to teachers&#x2019; and students&#x2019; procedural cognitive load. Therefore, we chose a limited set to minimize variation and used most strategies across all lessons (
                    <xref ref-type="boxed-text" rid="B2">Box 2</xref>). Additionally, we prepared summaries of all the teaching strategies we considered using.</p>
                <boxed-text id="B2" orientation="portrait" position="float">
                    <label>Box 2. </label>
                    <caption>
                        <title>Teaching strategies included in lessons.</title>
                    </caption>
                    <p>Strategies used across all lessons:
                        <list list-type="bullet">
                            <list-item>
                                <label>&#x2010;</label>
                                <p>Guided notetaking</p>
                            </list-item>
                            <list-item>
                                <label>&#x2010;</label>
                                <p>Small group work</p>
                            </list-item>
                            <list-item>
                                <label>&#x2010;</label>
                                <p>Response cards</p>
                            </list-item>
                            <list-item>
                                <label>&#x2010;</label>
                                <p>Homework &#x2013; collecting claims and choices about health actions</p>
                            </list-item>
                            <list-item>
                                <label>&#x2010;</label>
                                <p>Standard lesson structure</p>
                            </list-item>
                            <list-item>
                                <label>&#x2010;</label>
                                <p>Setting objectives and providing feedback</p>
                            </list-item>
                            <list-item>
                                <label>&#x2010;</label>
                                <p>Multimedia design</p>
                            </list-item>
                        </list>
                    </p>
                    <p>Strategies used in individual lessons:
                        <list list-type="bullet">
                            <list-item>
                                <label>&#x2010;</label>
                                <p>Concept mapping</p>
                            </list-item>
                            <list-item>
                                <label>&#x2010;</label>
                                <p>Concept cartoons</p>
                            </list-item>
                            <list-item>
                                <label>&#x2010;</label>
                                <p>Inquiry-based instruction</p>
                            </list-item>
                            <list-item>
                                <label>&#x2010;</label>
                                <p>Quiz</p>
                            </list-item>
                            <list-item>
                                <label>&#x2010;</label>
                                <p>Role play</p>
                            </list-item>
                        </list>
                    </p>
                    <p>For more detail, see also 
                        <ext-link ext-link-type="uri" xlink:href="https://drive.google.com/file/d/1t_Cv3tfCY5hFo2Yr_qgzPaEY7-YpCH-B/view">descriptions of teaching strategies we considered including</ext-link> (located under the Extra resources menu of the 
                        <ext-link ext-link-type="uri" xlink:href="http://Besmarthealth.org">Besmarthealth.org</ext-link> website).</p>
                </boxed-text>
                <p>
                    <bold>Collecting examples</bold>
                </p>
                <p>To illustrate concepts, and make lessons more engaging, we used a broad range of examples in the lessons involving conditions and health actions that students said they found interesting.
                    <sup>
                        <xref ref-type="bibr" rid="ref45">45</xref>
                    </sup> We also created a searchable collection of relevant health actions and health problems or goals that can be used to illustrate key concepts, with plain language summaries of the evidence for each example (
                    <xref ref-type="fig" rid="f9">Figure 9</xref>). The examples collection is part of the &#x201c;Extra resources&#x201d;.</p>
            </sec>
            <sec id="sec10">
                <title>Findings from Phase 2: Development cycles</title>
                <p>Using our findings from the Groundwork phase as a starting point, we conducted three development cycles of idea generation, prototyping, data collection and analysis, and stakeholder checking, which form the basis of this paper. The feedback was generally consistent regarding what people experienced as positive or problematic. Although there were far more positive findings, our main focus in collecting and reporting feedback was to identify problems that would require changes for the next iteration of the resources. We present the main findings thematically below.</p>
                <p>
                    <bold>
                        <italic toggle="yes">Positive, constructive findings</italic>
                    </bold>
                </p>
                <p>Many teachers and students appreciated the learning in these lessons and experienced it as relevant both for other subjects and for their daily lives. Many students participated actively in class, including students who normally were less active. Many teachers felt the Projector mode of lessons worked best, providing structure and visual support to the lesson and helping to focus class attention. The blackboard mode and print-outs work satisfactorily for classes without projectors, or as a back-up in the event of power failure. 
                    <xref ref-type="table" rid="T9">Table 9</xref> provides a detailed description of positive or constructive findings.</p>
                <table-wrap id="T9" orientation="portrait" position="float">
                    <label>Table 9. </label>
                    <caption>
                        <title>Positive, constructive findings.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Theme</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Description</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Illustrative quotes or design implications</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Relevance to daily life</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Many teachers and students said the lessons were relevant to their daily lives and enjoyable.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <italic toggle="yes">"I liked the idea that most of the lesson examples were daily life, we could easily relate."</italic> (Student, group interview, Uganda)
                                    <break/>
                                    <italic toggle="yes">&#x201c;The lessons enabled the students to think of a personal choice and the advantages and disadvantages of making a certain decision&#x201d;</italic> (Teacher, Kenya Group Interview).</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Engaging and confidence-building for students</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Most students found the lessons engaging and that they increased their confidence. In the pilot lessons, students participated actively in quizzes and activities, including some who normally were quiet.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <italic toggle="yes">&#x201c;I am shy, but group work made me stand to present and this will give me confidence.&#x201d;</italic> (Student, group interview, Uganda)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="2" valign="top">
                                    <bold>Structure and design of the resources</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">For the most part, the structure of the resources and the lessons was appreciated.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <italic toggle="yes">&#x201c;I am impressed of how you present the content in a clear and easy-to-follow manner. I also like how you organize the concepts in main groups and subgroups, it gives an immediate understanding of the focus areas.&#x201d;</italic> (International advisory group member)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">In Rwanda, stakeholders favored a lesson structure that encourages &#x201c;discovery&#x201d;, where the teacher does not provide explanations before an activity. However, in Kenya, stakeholders favored a lesson structure where the teacher provides definitions and explanations were upfront, which are then reinforced through learning activities.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Design implication: We added a &#x201c;discovery&#x201d; question at the start of each lesson and provided definitions and explanations before the activity.</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Usefulness for thinking critically about health actions</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Many teachers and students said the resources were useful for thinking critically about health actions and in general.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <italic toggle="yes">&#x201c;It was nice and educative. It will help us not to just follow band wagon. Like we buy certain toothpaste but just because it is many friends use it.&#x201d;</italic> (Student, group interview, Uganda)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Satisfaction with projector and blackboard modes</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">The projector mode worked best, with the illustrated slides helping focus class attention, and aiding understanding. The blackboard mode also seemed to work satisfactorily.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <italic toggle="yes">&#x201c;Projector based lesson plans helped both teacher and students to focus on one activity than the computer-based version. There wasn't any interruption during the lesson.&#x201d;</italic> (Observation pilot lesson, Rwanda)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Useful lesson printouts</bold>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Some teachers found the printouts a useful way of continuing lessons even when there was a power outage preventing them from using a projector.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <italic toggle="yes">&#x201c;After some few minutes, the Power went off and the projector stopped showing the lesson. The teacher immediately gives the printouts to students to follow the lesson. After 3 minutes, the power returned.&#x201d;</italic> (Observation pilot lesson, Rwanda)</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <p>
                    <bold>
                        <italic toggle="yes">Negative findings and how we addressed them</italic>
                    </bold>
                </p>
                <p>We resolved problems as they appeared and changed the design of the prototypes dramatically from the first to the final development cycle. However, four main thematic challenges persisted throughout development: issues regarding the student-computer mode of lesson plans, Time, Comprehension, and Examples.
                    <list list-type="bullet">
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Computers in classrooms took time to set up; equipment problems were common; students were often distracted by other online content; teachers found class discussions difficult to organise when students were using computers. Since teachers who had tried both the student-computer and Projector modes preferred the latter, we agreed with curriculum developers to drop the student-computer mode.</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>School schedules lacked time to teach lessons that were not in the curriculum, and teachers struggled to complete lessons within the allotted 40 minutes. We simplified and shortened lesson content as much as possible, and developed modules for teacher training workshops to increase teachers&#x2019; confidence and capability to teach the lessons.</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Students had varying degrees of difficulty understanding lesson content, sometimes displaying a misunderstanding that was exactly the opposite of what they were intended to learn. We added &#x201c;Common misunderstandings&#x201d; to the lesson background, and designed lessons to include more review opportunities and informal assessment questions. We are exploring experiences and views of potential adverse effects in separate process evaluations
                                <sup>
                                    <xref ref-type="bibr" rid="ref30">30</xref>
                                </sup>
                                <sup>,</sup>
                                <sup>
                                    <xref ref-type="bibr" rid="ref31">31</xref>
                                </sup>
                                <sup>,</sup>
                                <sup>
                                    <xref ref-type="bibr" rid="ref55">55</xref>
                                </sup> and in a qualitative evidence synthesis.
                                <sup>
                                    <xref ref-type="bibr" rid="ref56">56</xref>
                                </sup>
                            </p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>We struggled finding appropriate examples of reliable and unreliable claims, as students often thought the lesson was about the example rather than the underlying Key Concept. Our solutions included finding a balance between real and fictional, well-labeled examples, guidance and prompts for teachers (including suggestions to find their own examples), and developing an example collection for teachers to find alternatives.</p>
                        </list-item>
                    </list>
                </p>
                <p>
                    <xref ref-type="table" rid="T10">Tables 10</xref>-
                    <xref ref-type="table" rid="T13">13</xref> provide a more detailed description of challenges and solutions.</p>
                <table-wrap id="T10" orientation="portrait" position="float">
                    <label>Table 10. </label>
                    <caption>
                        <title>Difficulties using the Student-computer mode.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Description</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Illustrative quotes</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Design and content implications for the final version</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Some curriculum developers wanted more media-rich, interactive resources that students could use for self-study in computer labs. However, we found technical, logistical, and behavioural problems with the student-computer mode:
                                    <break/>
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>&#x2022;</label>
                                                <p>Valuable teacher time used for setting up and charging the computers beforehand.</p>
                                            </list-item>
                                            <list-item>
                                                <label>&#x2022;</label>
                                                <p>Broken computers.</p>
                                            </list-item>
                                            <list-item>
                                                <label>&#x2022;</label>
                                                <p>Necessity for students to sometimes share a computer.</p>
                                            </list-item>
                                            <list-item>
                                                <label>&#x2022;</label>
                                                <p>Students needing help finding browsers and reopening the resources after power outages.</p>
                                            </list-item>
                                            <list-item>
                                                <label>&#x2022;</label>
                                                <p>Students cheating on quizzes or avoiding discussing things by opening the teacher resources or jumping ahead in the lessons to find the correct answers.</p>
                                            </list-item>
                                            <list-item>
                                                <label>&#x2022;</label>
                                                <p>Students visiting other websites during the class.</p>
                                            </list-item>
                                            <list-item>
                                                <label>&#x2022;</label>
                                                <p>Group discussions, one of the teaching strategies we had prioritized, not working well.</p>
                                            </list-item>
                                        </list>
                                    </p>Teachers who had tried both the student-computer and projector modes preferred the latter.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <italic toggle="yes">&#x201c;It is not easy for a teacher to handle technical issues while teaching. It disturbs her and the students also lose the focus. Most technical issues they experience, is to reopen the resources, to restart the computer, to help the students find the pages of where the teacher is focusing on, and the power issues.&#x201d;</italic> (Observation pilot lesson, Rwanda)
                                    <break/>
                                    <italic toggle="yes">&#x201c;The students were told to discuss in groups the activity part 1,2 and 3 but the students did not focus on doing these activities, they were busy exploring how the laptops work, visiting other websites, and others were writing the notes instead of discussing in groups.&#x201d;</italic> (Observation pilot lesson, Rwanda)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">After the first few pilot lessons, in consultation with the curriculum developers, we decided to drop the student-computer mode.</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <table-wrap id="T11" orientation="portrait" position="float">
                    <label>Table 11. </label>
                    <caption>
                        <title>Time limitations.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Description</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Illustrative quotes</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Design and content implications for the final version</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">With early prototypes, lessons often took more than the intended 40 minutes because:
                                    <break/>
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>&#x2022;</label>
                                                <p>The content, including key terms, was often unfamiliar to students and teachers.</p>
                                            </list-item>
                                            <list-item>
                                                <label>&#x2022;</label>
                                                <p>Some of the teaching strategies, such as getting students to take structured notes, and organising small group discussions, were time-consuming.</p>
                                            </list-item>
                                        </list>
                                    </p>In pilots, teachers tried to save time by skipping parts of, or entire, lessons or by falling back on didactic teaching strategies.
                                    <break/>Participating schools squeezed pilot lessons into their schedules at a time when schedules were already under extra pressure due to pandemic-related school closures. Classes were often held before or after regular school hours, when both teachers and students were tired.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <italic toggle="yes">"I think the teacher should give us more time to think because you could just start thinking about an answer and the teacher says the 3 minutes are done"</italic> (Student, group interview, Uganda)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">We suggested reducing the number of IHC Key Concepts included. Due to resistance to this in stakeholder checking, we rearranged content and combined some lessons.
                                    <break/>We made a number of other timesaving changes:
                                    <break/>
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>&#x2022;</label>
                                                <p>removed quizzes and shortened reviews in most lessons,</p>
                                            </list-item>
                                            <list-item>
                                                <label>&#x2022;</label>
                                                <p>limited activities to one per lesson,</p>
                                            </list-item>
                                            <list-item>
                                                <label>&#x2022;</label>
                                                <p>used buzz-groups (2-3 students who are sitting next to each other) or whole-class discussions instead of small-group work,</p>
                                            </list-item>
                                            <list-item>
                                                <label>&#x2022;</label>
                                                <p>developed printable student handouts and classroom posters to reduce students&#x2019; need to take notes.</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <table-wrap id="T12" orientation="portrait" position="float">
                    <label>Table 12. </label>
                    <caption>
                        <title>Problems with understanding.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Description</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Illustrative quotes</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Design and content implications for the final version</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Some students did not understand some of the content. When asked to describe take-home messages from a lesson, students sometimes displayed a misunderstanding that was exactly the opposite of what they were intended to learn.
                                    <break/>Many students performed poorly on the test at the end of the pilot. Low scores in all three countries were likely in part linked to teachers&#x2019; lack of familiarity with the content lessons&#x2014;especially concepts about research evidence. Results can be found in the dataset:&#x201c;Pilot data and test results - analysis of problems and proposed solutions.pdf&#x201d;.
                                    <break/>Teachers emphasized the need for checking students&#x2019; comprehension from lesson to lesson.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <italic toggle="yes">&#x201c;Whenever I go to buy a medicine, I need to check how long it has been in use and how many have used it&#x201d;</italic> (Rwanda, student interview)
                                    <break/>
                                    <italic toggle="yes">&#x201c;Personal experience can help to have information about any disease if you have experienced it&#x201d;</italic> (Rwanda, student interview)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">To support students&#x2019; and teachers&#x2019; understanding:
                                    <break/>
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>&#x2022;</label>
                                                <p>We iteratively simplified the lesson structure, language, and content.</p>
                                            </list-item>
                                            <list-item>
                                                <label>&#x2022;</label>
                                                <p>We added &#x201c;Common misunderstandings&#x201d; to each lesson Background.</p>
                                            </list-item>
                                            <list-item>
                                                <label>&#x2022;</label>
                                                <p>We added review questions and short key messages at the end of lessons, which are repeated at the start of the next lesson. We developed printouts with definitions of key terms.</p>
                                            </list-item>
                                        </list>
                                    </p>To support teachers&#x2019; evaluation of students understanding and progress, we incorporated two review lessons (lessons 5 and 10) with quizzes.
                                    <break/>To support teachers&#x2019; understanding of the content and confidence in using the resources, we added a teacher training component to the intervention: a two-day workshop with presentations and activity materials, introducing teachers to the resources, teaching strategies, and content of each lesson, as well as providing teaching and preparation tips. We designed these training materials to be used by teachers who were already familiar with the resources (e.g., those who participated in pilots), so training would not be dependent on our team&#x2019;s participation and would be scalable.</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <table-wrap id="T13" orientation="portrait" position="float">
                    <label>Table 13. </label>
                    <caption>
                        <title>Unsuitable or distracting examples illustrating the Key Concepts.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Description</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Illustrative quotes</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Design and content implications for the final version</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Familiar examples engaged students, but often led to class discussions focused on the specific example rather than the underlying, generic concept that it illustrated.
                                    <break/>Some students thought that the lesson was about the information in the example, and not about learning to think critically about health information.
                                    <break/>On the other hand, fictional or unfamiliar examples appeared less engaging, because students could not relate them to their own lives or found them confusing.
                                    <break/>Many students did not readily question the reliability of claims about Covid-19 measures that were already widely implemented.
                                    <break/>Some teachers proposed that we add examples that were more familiar to students. In many cases, teachers supplemented with their own examples.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <italic toggle="yes">&#x201c;They take examples as key messages of the lesson they learnt.&#x201d;</italic> (Rwanda, teacher group interview)
                                    <break/>
                                    <italic toggle="yes">&#x201c;Student were not able to give examples of other possible options that could be made if someone doesn&#x2019;t choose to cool a burn with running water. This example was not familiar to them.&#x201d;</italic> (Rwanda, observation pilot lesson)
                                    <break/>
                                    <italic toggle="yes">&#x201c;Some examples of Covid-19 used in these lessons limit students to think big. For example, if you are asking the students if wearing a mask is effective in reducing the spread of Covid-19, they will all say yes, because they are all using them, without even thinking if they are good to use or not.&#x201d;</italic> (Rwanda, teacher group interview)
                                    <break/>
                                    <italic toggle="yes">&#x201c;She just suggested adding more information about adolescent health and more examples of claims that are often told to the youth such as believing that sexual intercourse wipes away the pimples and lessens the menstrual cramps during the period.&#x201d;</italic> (Rwanda, teacher interview)
                                    <break/>
                                    <italic toggle="yes">&#x201c;The teacher used other examples that students seemed to relate with: use of marijuana and its effect on school dropout, anti-retroviral drugs and death rates, circumcision and HIV, and a community with drunkenness and community development.&#x201d;</italic> (Kenya, observation pilot lesson)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">As far as possible, we used real, familiar, and relevant examples, drawing on examples collected from students. Where we were unable to identify a real example that seemed appropriate, we used fictional examples and tried to clearly indicate that they were fictional.
                                    <break/>In the teachers&#x2019; guide, we suggested teachers could use their own examples or find new ones in the searchable collection of health actions in the extra resources. In the teachers&#x2019; guide and the teacher training materials, we emphasized that the examples must illustrate the generic concepts, not just draw attention to specific health conditions, actions, or claims.
                                    <break/>In the background section of each lesson plan, we summarised research evidence about the used in that lesson. We also provided summaries of the evidence for the effects of all the health actions used in the resources in the searchable collection of health actions. We did this to ensure that the teachers were familiar with the examples, felt comfortable using them, and were prepared to prevent misunderstandings about the reliability of claims or evidence relating to them.</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
            </sec>
            <sec id="sec11">
                <title>Covid-19 consequences</title>
                <p>The COVID-19 pandemic disrupted our work in many ways. At times, social-distancing and travel restrictions, as well as school closures, prohibited in-person meetings and data collection and piloting. When schools reopened, teachers were pressed to make up for lost time, sometimes rushing to finish a pilot lesson or not completing it. On the other hand, the abundance of unreliable claims about Covid-19 provided timely examples and motivation.</p>
                <disp-quote>
                    <p>
                        <italic toggle="yes">&#x201c;The lesson itself was very easy to understand because the students have already experienced what was used as example in the content (closing schools to reduce the spread of covid-19 infections).&#x201d;</italic> (Rwanda, Observation pilot lesson)</p>
                </disp-quote>
                <p>Workarounds to challenges included communicating with stakeholders individually via audio or video call, or chat, and conducting some of interviews with home networks.</p>
            </sec>
        </sec>
        <sec id="sec12" sec-type="discussion">
            <title>Discussion</title>
            <p>Using a human-centred design approach, we developed adaptable, digital resources for teaching critical thinking about health in secondary schools in Kenya, Rwanda, and Uganda. In Phase 1 of the design, we gained insight into user and stakeholder needs, and the wider educational contexts. In Phase 2, we iteratively developed prototypes by generating ideas, prototyping, collecting and analysing data, and checking our ideas and analysis with stakeholders.</p>
            <sec id="sec13">
                <title>Implications</title>
                <p>In many countries, curriculum developers are moving away from traditional knowledge-based curricula to competency-based curricula, with critical thinking among the core competencies,
                    <sup>
                        <xref ref-type="bibr" rid="ref57">57</xref>
                    </sup> including in Kenya, Rwanda, and Uganda.
                    <sup>
                        <xref ref-type="bibr" rid="ref39">39</xref>
                    </sup>
                    <sup>&#x2013;</sup>
                    <sup>
                        <xref ref-type="bibr" rid="ref41">41</xref>
                    </sup> However, our context analyses showed that teachers lacked training and resources to teach critical thinking.
                    <sup>
                        <xref ref-type="bibr" rid="ref39">39</xref>
                    </sup>
                    <sup>&#x2013;</sup>
                    <sup>
                        <xref ref-type="bibr" rid="ref41">41</xref>
                    </sup>
                </p>
                <p>In their systematic review of strategies for teaching students to think critically, Abrami 
                    <italic toggle="yes">et al.</italic> found that three strategies were most effective, especially when combined: &#x201c;the opportunity for dialogue, the exposure of students to authentic or situated problems and examples, and mentoring&#x201d;.
                    <sup>
                        <xref ref-type="bibr" rid="ref58">58</xref>
                    </sup> Based on those findings, and findings from our overview of systematic reviews,
                    <sup>
                        <xref ref-type="bibr" rid="ref44">44</xref>
                    </sup> we focused on using authentic examples and discussion activities in our secondary school resources.</p>
                <p>A review of education technology in low-income countries distinguishes between two categories of digital interventions: computer aided learning (CAL) and computer aided instruction (CAI).
                    <sup>
                        <xref ref-type="bibr" rid="ref59">59</xref>
                    </sup> Broadly speaking, CAL interventions are designed for the student-as-user, and either complement or supplement classroom instruction. CAI interventions, on the other hand, are designed for the teacher-as-user, and aim to enhance the quality of instruction. We developed and piloted resources for both CAL (the student-computer mode of lessons) and CAI (the blackboard and projector modes of lessons).</p>
                <p>We found a variety of problems with the student-computer (CAL) resources. Many of the problems were logistical or technical, and not specific to our project, such as time needed to set up and charge computers, faulty or missing equipment, and unstable electricity. In addition, some curriculum developers (where student-computer resources were piloted) said that the resources lacked media-richness (such as animations or videos) as well as interactivity that we could not feasibly develop in this project and that teachers and students were possibly not experienced enough to use.</p>
                <p>Regardless of the level of ICT preparedness, it might be that self-led study strategies and CAL interventions are not the best starting point for developing critical thinking skills, since it is more challenging to creating opportunities for dialogue when students are alone behind a screen, working at different paces from each other. In our case, developing functionality for dialogue to take place on the computer was not an option, due to technical barriers in the settings, such as lack or unreliable internet access. Computer-based mentoring
                    <sup>
                        <xref ref-type="bibr" rid="ref60">60</xref>
                    </sup>
                    <sup>&#x2013;</sup>
                    <sup>
                        <xref ref-type="bibr" rid="ref63">63</xref>
                    </sup> would require much more sophisticated programming than we had resources for. Moreover, less literate and less computer-literate students would be at a disadvantage. In their review, Abrami and colleagues&#x2019; found that discussion was especially effective when the teacher posed questions and there were whole-class, teacher-led discussions, or teacher-led group discussions.
                    <sup>
                        <xref ref-type="bibr" rid="ref58">58</xref>
                    </sup>
                </p>
                <p>Rwandan teachers who piloted both the student-computer and projector resources preferred the latter, with the blackboard and printed resources as a backup for when electricity failed. Besides being technically less demanding, the slides seemed to better activate students, support small and large-group discussion, and focus collective attention. Moreover, teachers can download and tailor slides. The lower-tech CAI modes require much less investment in equipment than high-tech CAL modes and could dramatically lower the threshold for bringing digital learning resources that support critical thinking into low-resource classrooms.</p>
            </sec>
            <sec id="sec14">
                <title>Strengths and limitations</title>
                <p>Strengths of this study include comprehensive groundwork; several development cycles; including pilots of all lessons in three countries; input from a wide variety of stakeholders and participants; systematic methods used to prioritise content and identify effective teaching strategies; data collection using complementary, mixed methods; independent initial coding and analysis by more than one researcher; and stakeholder checking to triangulate analyses.</p>
                <p>A limitation is that the project team developed the prototypes and collected and coded data. This might have biased participants to give positive feedback, or introduced bias in the analysis, leading to an exaggeration of positive feedback or lack of attention to negative feedback. We took measures to mitigate this: the interview guide included questions that explicitly encouraged participants to provide negative feedback; data was collected in three countries and coding in each country was reviewed by two researchers in order to reduce potential for bias; we introduced &#x201c;stakeholder checking&#x201d; to triangulate our data analyses and check that the solutions we developed were appropriate.</p>
                <p>It is possible that the amount of data we collected placed an undue burden on participants and other stakeholders. We are exploring this in a separate stakeholder evaluation.
                    <sup>
                        <xref ref-type="bibr" rid="ref38">38</xref>
                    </sup> It is also possible that the prototypes caused harm to some students who misunderstood concepts or examples. We are exploring potential adverse effects of the final resources in process evaluations
                    <sup>
                        <xref ref-type="bibr" rid="ref30">30</xref>
                    </sup>
                    <sup>,</sup>
                    <sup>
                        <xref ref-type="bibr" rid="ref31">31</xref>
                    </sup>
                    <sup>,</sup>
                    <sup>
                        <xref ref-type="bibr" rid="ref55">55</xref>
                    </sup> and a qualitative evidence synthesis.
                    <sup>
                        <xref ref-type="bibr" rid="ref56">56</xref>
                    </sup>
                </p>
                <p>
                    <italic toggle="yes">Reflexivity considerations</italic>
                </p>
                <p>The core project team all have backgrounds as public health researchers, while the stakeholders recruited for the purposes of collaborating and providing feedback have mostly backgrounds in education with no previous engagement in this research topic. The core project team members are from many different settings, while all stakeholders are from East Africa with the exception of the international advisory group. The PhD fellows and several other core team members were working full-on this project, and therefore highly invested in a positive outcome, while stakeholders were participating voluntarily, in addition to their other full-time work or study commitments.</p>
                <p>We have tried to be mindful of our differing agendas, cultural perspectives, and the ways in which the core team&#x2019;s ambitions might influence the outcome of the work or place undue burden on the participants. We discussed these topics frequently during weekly core team meetings and have also explored some of these questions using more structured methods, designed as separate studies. The context analyses we conducted at the beginning of this work helped us view our research agenda from the perspective of teachers and curriculum developers and understand whether and how our research might better align with existing objectives within the three educational systems. The stakeholder engagement assessment (manuscript under development) provided stakeholders with opportunities to give us feedback about how they experienced their participation while it was ongoing. The qualitative evidence synthesis of post-trial process evaluations (manuscript under development) will help us understand if there have been any adverse effects of the resources, seen from the point of view of the participants.</p>
                <p>Relationships between the core team and recruited stakeholders developed over time, and some people who were initially recruited as participants became engaged to the degree that they fulfilled requirements for co-authorship of this study.</p>
            </sec>
        </sec>
        <sec id="sec15" sec-type="conclusion">
            <title>Conclusion</title>
            <p>Using a human-centred design approach, we created adaptable, digital resources for teaching lower secondary school students to think critically about health actions in ten 40-minute lessons. Teachers and students in Kenya, Rwanda and Uganda found the lessons relevant and useful. The 
                <ext-link ext-link-type="uri" xlink:href="https://besmarthealth.org/">open access resources</ext-link> are free to use and can be translated and adapted to other settings. Designed to accommodate use in classrooms with differing digital infrastructure, such as lack of internet connectivity or unstable electricity, they include materials in two modes for classrooms equipped with 
                <ext-link ext-link-type="uri" xlink:href="https://besmarthealth.org/static-pages/1vX9z2NUMkZHMMyAECJOY8yfwRW9RoYc5IwD6IP6bpTA">blackboards</ext-link> or 
                <ext-link ext-link-type="uri" xlink:href="https://besmarthealth.org/static-pages/1HalIx5pjweAvAOKKuAPcgPYbU4T8QcpQAwUpuB8G7DY">projectors</ext-link>. Teachers with access to a projector preferred the projector resources. In addition to the lessons, resources include a 
                <ext-link ext-link-type="uri" xlink:href="https://besmarthealth.org/static-pages/1snngMuXvtAyJaXNuvDKyTh43ZkWNNIXi2Dq8FdMLQ9Y">teachers&#x2019; guide</ext-link>, 
                <ext-link ext-link-type="uri" xlink:href="https://besmarthealth.org/glossary">glossary</ext-link>, 
                <ext-link ext-link-type="uri" xlink:href="http://besmarthealth.org/health-actions">a searchable set of alternative examples of health actions</ext-link>, summaries of 
                <ext-link ext-link-type="uri" xlink:href="https://drive.google.com/file/d/1t_Cv3tfCY5hFo2Yr_qgzPaEY7-YpCH-B/view">teaching strategies for critical thinking</ext-link>, and 
                <ext-link ext-link-type="uri" xlink:href="https://besmarthealth.org/static-pages/17hvpgg3shWpvY8rfQl5HCcnK_o57-CpzFxiXK6Iyu3E">teacher training materials</ext-link>. The Covid-19 pandemic disrupted the design of the resources, but also provided timely examples and motivation to learn.</p>
            <p>A Prospective meta-analysis synthesizing the results of the three randomised trials has shown that the resources led to a large improvement in the ability of students and teachers to think critically about health choices, though only 42% of students achieved a passing score.
                <sup>
                    <xref ref-type="bibr" rid="ref64">64</xref>
                </sup> Next research steps are well underway: process evaluations of the three trials and one-year follow up studies.</p>
        </sec>
    </body>
    <back>
        <sec id="sec18" sec-type="data-availability">
            <title>Data availability statement</title>
            <sec id="sec19">
                <title>Underlying data</title>
                <p>Zenodo. Dataset for &#x201c;Teaching critical thinking about health information and choices in secondary schools: human-centred design of digital resources&#x201d;, 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.5281/zenodo.7695782">https://doi.org/10.5281/zenodo.7695782</ext-link>.
                    <sup>

                        <xref ref-type="bibr" rid="ref47">47</xref>
</sup>
                </p>
                <p>This project contains the following underlying data:
                    <list list-type="bullet">
                        <list-item>
                            <label>&#x2022;</label>
                            <p>

                                <ext-link ext-link-type="uri" xlink:href="https://zenodo.org/record/7712043/files/DevelopmentCycle1__data%20feedback%20and%20observations.csv?download=1">DevelopmentCycle1__data feedback and observations.csv</ext-link> (Coded datapoints extracted in Development cycle 1 from individual/group interviews with teachers/students and observations of lesson pilots in Rwanda, Kenya and Uganda)</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>

                                <ext-link ext-link-type="uri" xlink:href="https://zenodo.org/record/7712043/files/DevelopmentCycle1_internal%20team%20feedback.csv?download=1">DevelopmentCycle1_internal team feedback.csv</ext-link> (Feedback, comments, suggestions from our research team during Development cycle 1)</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>

                                <ext-link ext-link-type="uri" xlink:href="https://zenodo.org/record/7712043/files/DevelopmentCycle1_interntl-advisory-grp-dec-jan-2020.csv?download=1">DevelopmentCycle1_interntl-advisory-grp-dec-jan-2020.csv</ext-link> (First round of feedback from international advisory group, via email)</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>

                                <ext-link ext-link-type="uri" xlink:href="https://zenodo.org/record/7712043/files/DevelopmentCycle1_interntl-advisory-grp-jun-aug-2020.csv?download=1">DevelopmentCycle1_interntl-advisory-grp-jun-aug-2020.csv</ext-link> (Second round of feedback from international advisory group, via email)</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>

                                <ext-link ext-link-type="uri" xlink:href="https://zenodo.org/record/7712043/files/DevelopmentCycle1_interntl-advisory-grp-proto1.2.csv?download=1">DevelopmentCycle1_interntl-advisory-grp-proto1.2.csv</ext-link> (Third round of feedback from international advisory group, via email)</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>

                                <ext-link ext-link-type="uri" xlink:href="https://zenodo.org/record/7712043/files/DevelopmentCycle1_legend.csv?download=1">DevelopmentCycle1_legend.csv</ext-link> (Description of implications codes we used to assess the importance of observations and feedback for the next iteration of the resources, e.g., &#x201c;Problem/Showstopper/A problem that we should address&#x201d;) in Development Cycle 2</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>

                                <ext-link ext-link-type="uri" xlink:href="https://zenodo.org/record/7712043/files/DevelopmentCycle2__data%20feedback%20and%20observations%20data.csv?download=1">DevelopmentCycle2__data feedback and observations data.csv</ext-link> (Coded datapoints extracted in Development cycle 2 from individual/group interviews with teachers/students and observations of lesson pilots in Rwanda, Kenya and Uganda,)</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>

                                <ext-link ext-link-type="uri" xlink:href="https://zenodo.org/record/7712043/files/DevelopmentCycle2_codes%20and%20response%20options.csv?download=1">DevelopmentCycle2_codes and response options.csv</ext-link> (List of codes/response options used in Development cycle 2 to code or describe datapoints)</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>

                                <ext-link ext-link-type="uri" xlink:href="https://zenodo.org/record/7712043/files/DevelopmentCycle2_definitions.csv?download=1">DevelopmentCycle2_definitions.csv</ext-link> (Description of &#x201c;nature&#x201d;, &#x201c;implications&#x201d; and &#x201c;Action for resolving&#x201d; codes used in Development cycle 2)</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>

                                <ext-link ext-link-type="uri" xlink:href="https://zenodo.org/record/7712043/files/DevelopmentCycle2_internal%20team%20feedback.csv?download=1">DevelopmentCycle2_internal team feedback.csv</ext-link> (Feedback, comments, suggestions from our research team during Development cycle 2)</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>

                                <ext-link ext-link-type="uri" xlink:href="https://zenodo.org/record/7712043/files/Pilot%20data%20and%20test%20results%20-%20analysis%20of%20problems%20and%20proposed%20solutions.pdf?download=1">Pilot data and test results - analysis of problems and proposed solutions.pdf</ext-link> (Analysis of problems and proposed solutions after lesson pilots at the end of Development cycle 2 that we presented to curriculum developers for stakeholder checking and input)
</p>
                        </list-item>
                    </list>
                </p>
            </sec>
            <sec id="sec20">
                <title>Extended data</title>
                <p>Zenodo. Extended dataset and Coreq Checklist for &#x201c;Teaching critical thinking about health information and choices in secondary schools: human-centred design of digital resources&#x201d;, 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.5281/zenodo.7806139">https://doi.org/10.5281/zenodo.7806139</ext-link>.
                    <sup>

                        <xref ref-type="bibr" rid="ref48">48</xref>
</sup>
                </p>
                <p>This project contains the following extended data:
                    <list list-type="bullet">
                        <list-item>
                            <label>&#x2022;</label>
                            <p>

                                <ext-link ext-link-type="uri" xlink:href="https://zenodo.org/record/7806140/files/COREQ_checklist%20New.pdf?download=1">COREQ_checklist New.pdf</ext-link> (COREQ checklist for this article)</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>

                                <ext-link ext-link-type="uri" xlink:href="https://zenodo.org/record/7806140/files/Group%20Interview%20guide%20Post-Pilot%20-%20Students%20Group%20interview%20guide.docx?download=1">Group Interview guide Post-Pilot - Students Group interview guide.docx</ext-link> (Guide used as a basis for interviewing groups of students after they had participated in piloting lessons at the end of Development cycle 2)</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>

                                <ext-link ext-link-type="uri" xlink:href="https://zenodo.org/record/7806140/files/Group%20Interview%20guide%20Post-Pilot%20-%20Teachers.docx?download=1">Group Interview guide Post-Pilot - Teachers.docx</ext-link> (Guide used as a basis for interviewing teachers after they had piloted lessons at the end of Development cycle 2)</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>

                                <ext-link ext-link-type="uri" xlink:href="https://zenodo.org/record/7806140/files/Interveiw%20guide%20Early%20-%20Student%20network.docx?download=1">Interveiw guide Early - Student network.docx</ext-link> (Guide used as a basis for interviewing students in Development cycle 1)</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>

                                <ext-link ext-link-type="uri" xlink:href="https://zenodo.org/record/7806140/files/Interview%20guide%20Early%20-%20Curriculum%20develop%20Questionnaire.docx?download=1">Interview guide Early - Curriculum develop Questionnaire.docx</ext-link> (Guide used as a basis for interviewing curriculum developers in Development cycle 1)</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>

                                <ext-link ext-link-type="uri" xlink:href="https://zenodo.org/record/7806140/files/Interview%20guide%20Pilot%20-%20Teachers%20User%20testing%20interview%20guide.docx?download=1">Interview guide Pilot - Teachers User testing interview guide.docx</ext-link> (Guide used as a basis for user test interviews with participating teachers in pilot lessons at the end of Development cycle 2)</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>

                                <ext-link ext-link-type="uri" xlink:href="https://zenodo.org/record/7806140/files/Interview%20Guide%20Pre-pilot%20-%20Teacher-Student%20-%20User%20test.docx?download=1">Interview Guide Pre-pilot - Teacher-Student - User test.docx</ext-link> (Guide used as a basis for user test interviews of students and teachers before they participated in pilot lessons at the end of Development Cycle 2)</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>

                                <ext-link ext-link-type="uri" xlink:href="https://zenodo.org/record/7806140/files/Observation%20form%20Pilot%20-%20Observers.docx?download=1">Observation form Pilot - Observers.docx</ext-link> (Form used by observers to structure observation data of pilot lessons)
</p>
                        </list-item>
                    </list>
                </p>
                <p>Data are available under the terms of the 
                    <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0</ext-link> International Public License.</p>
            </sec>
        </sec>
        <ack>
            <title>Acknowledgments</title>
            <p>We would like to thank all of the students, teachers, and schools who generously gave of their time to participate in networks and pilots. In particular, we would like to thank Besweri Wandera, Joseph Jude Agaba, Enock Kiyemba, Deogratious Ssekyole, Dan Bubaale, Fredrick Kiyingi Kinobe, Grace Namakula, Peter Kizza, Edward Kanoonya, Enock Kiyemba, Judith Nantongo, Patrick Ssendujja, Steven Musisi, John Bosco Kalangwa, Paul Sendi, Grace Namakula, Bridgious Kato, Charles Musabi, Ann Murangira, Stanely Shitanda, lynnet Juma, Pamela Nandi, Robert Onyango, Brian Okoth, Emmanuel Otieno, Rose Omondi, Bridgit Abayo, Fredick Okoth, John Ouko, Lawrence Ariang&#x2019;a, Innocent Uwimana, Paul Nkundimana, Aloys Kayinamura, Janvier Ntibizerwa, Aaron Habarurema, Donat Nkurunziza, Chui Hsia, and Christine Holst. We also thank the Kenya Institute of Curriculum Development (KICD), Rwanda Basic Education Board (REB), and National Curriculum Development Centre (NCDC) in Uganda for their ongoing encouragement and collaboration.</p>
        </ack>
        <ref-list>
            <title>References</title>
            <ref id="ref1">
                <label>1</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Oxman</surname>
                            <given-names>M</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Larun</surname>
                            <given-names>L</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Gaxiola</surname>
                            <given-names>GP</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Quality of information in news media reports about the effects of health interventions: systematic review and meta-analyses.</article-title>
                    <source>

                        <italic toggle="yes">F1000Res.</italic>
</source>
                    <year>2021</year>;<volume>10</volume>:<fpage>10</fpage>.
                    <pub-id pub-id-type="doi">10.12688/f1000research.52894.1</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref2">
                <label>2</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Boutron</surname>
                            <given-names>I</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Haneef</surname>
                            <given-names>R</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Yavchitz</surname>
                            <given-names>A</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Three randomized controlled trials evaluating the impact of &#x201c;spin&#x201d; in health news stories reporting studies of pharmacologic treatments on patients&#x2019;/caregivers&#x2019; interpretation of treatment benefit.</article-title>
                    <source>

                        <italic toggle="yes">BMC Med.</italic>
</source>
                    <year>2019</year>;<volume>17</volume>(<issue>1</issue>):<fpage>1</fpage>&#x2013;<lpage>10</lpage>.</mixed-citation>
            </ref>
            <ref id="ref3">
                <label>3</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Dahlgren</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Furuseth-Olsen</surname>
                            <given-names>K</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Rose</surname>
                            <given-names>CJ</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>The Norwegian public&#x2019;s ability to assess treatment claims: results of a cross-sectional study of critical health literacy.</article-title>
                    <source>

                        <italic toggle="yes">F1000Res.</italic>
</source>
                    <year>2021</year>;<volume>9</volume>(<issue>179</issue>):<fpage>179</fpage>.
                    <pub-id pub-id-type="doi">10.12688/f1000research.21902.2</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref4">
                <label>4</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Li</surname>
                            <given-names>HO-Y</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Bailey</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Huynh</surname>
                            <given-names>D</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>YouTube as a source of information on COVID-19: a pandemic of misinformation?</article-title>
                    <source>

                        <italic toggle="yes">BMJ Glob. Health.</italic>
</source>
                    <year>2020</year>;<volume>5</volume>(<issue>5</issue>):<fpage>e002604</fpage>.
                    <pub-id pub-id-type="pmid">32409327</pub-id>
                    <pub-id pub-id-type="doi">10.1136/bmjgh-2020-002604</pub-id>
                    <pub-id pub-id-type="pmcid">PMC7228483</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref5">
                <label>5</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Sharp</surname>
                            <given-names>MK</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Forde</surname>
                            <given-names>Z</given-names>
                        </name>

                        <name name-style="western">
                            <surname>McGeown</surname>
                            <given-names>C</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Irish media coverage of COVID-19 evidence-based research reports from one national agency.</article-title>
                    <source>

                        <italic toggle="yes">Int. J. Health Policy Manag.</italic>
</source>
                    <year>2021</year>;<volume>11</volume>:<fpage>2464</fpage>&#x2013;<lpage>2475</lpage>.
                    <pub-id pub-id-type="pmid">35042323</pub-id>
                    <pub-id pub-id-type="doi">10.34172/ijhpm.2021.169</pub-id>
                    <pub-id pub-id-type="pmcid">PMC9818095</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref6">
                <label>6</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Wagner</surname>
                            <given-names>DN</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Marcon</surname>
                            <given-names>AR</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Caulfield</surname>
                            <given-names>T</given-names>
                        </name>
</person-group>:
                    <article-title>&#x201c;Immune Boosting&#x201d; in the time of COVID: selling immunity on Instagram.</article-title>
                    <source>

                        <italic toggle="yes">Allergy, Asthma Clin. Immunol.</italic>
</source>
                    <year>2020</year>;<volume>16</volume>(<issue>1</issue>):<fpage>1</fpage>&#x2013;<lpage>5</lpage>.</mixed-citation>
            </ref>
            <ref id="ref7">
                <label>7</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Janiaud</surname>
                            <given-names>P</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Axfors</surname>
                            <given-names>C</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Hooft</surname>
                            <given-names>J</given-names>
                            <prefix>van't</prefix>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>The worldwide clinical trial research response to the COVID-19 pandemic - the first 100 days [version 2; peer review: 2 approved].</article-title>
                    <source>

                        <italic toggle="yes">F1000Res.</italic>
</source>
                    <year>2020</year>;<volume>9</volume>(<issue>1193</issue>).
                    <pub-id pub-id-type="doi">10.12688/f1000research.26707.1</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref8">
                <label>8</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Jones</surname>
                            <given-names>CW</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Woodford</surname>
                            <given-names>AL</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Platts-Mills</surname>
                            <given-names>TF</given-names>
                        </name>
</person-group>:
                    <article-title>Characteristics of COVID-19 clinical trials registered with ClinicalTrials. gov: cross-sectional analysis.</article-title>
                    <source>

                        <italic toggle="yes">BMJ Open.</italic>
</source>
                    <year>2020</year>;<volume>10</volume>(<issue>9</issue>):<fpage>e041276</fpage>.
                    <pub-id pub-id-type="doi">10.1136/bmjopen-2020-041276</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref9">
                <label>9</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Glasziou</surname>
                            <given-names>PP</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Sanders</surname>
                            <given-names>S</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Hoffmann</surname>
                            <given-names>T</given-names>
                        </name>
</person-group>:
                    <article-title>Waste in covid-19 research.</article-title>
                    <source>

                        <italic toggle="yes">BMJ.</italic>
</source>
                    <year>2020</year>;<volume>369</volume>:<fpage>m1847</fpage>.
                    <pub-id pub-id-type="doi">10.1136/bmj.m1847</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref10">
                <label>10</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Pian</surname>
                            <given-names>W</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Chi</surname>
                            <given-names>J</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Ma</surname>
                            <given-names>F</given-names>
                        </name>
</person-group>:
                    <article-title>The causes, impacts and countermeasures of COVID-19 &#x201c;Infodemic&#x201d;: A systematic review using narrative synthesis.</article-title>
                    <source>

                        <italic toggle="yes">Inf. Process. Manag.</italic>
</source>
                    <year>2021</year>;<volume>58</volume>(<issue>6</issue>):<fpage>102713</fpage>.
                    <pub-id pub-id-type="pmid">34720340</pub-id>
                    <pub-id pub-id-type="doi">10.1016/j.ipm.2021.102713</pub-id>
                    <pub-id pub-id-type="pmcid">PMC8545871</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref11">
                <label>11</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Borges do Nascimento</surname>
                            <given-names>IJ</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Pizarro</surname>
                            <given-names>AB</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Almeida</surname>
                            <given-names>JM</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Infodemics and health misinformation: a systematic review of reviews.</article-title>
                    <source>

                        <italic toggle="yes">Bull. World Health Organ.</italic>
</source>
                    <year>2022</year>;<volume>100</volume>(<issue>9</issue>):<fpage>544</fpage>&#x2013;<lpage>561</lpage>.
                    <pub-id pub-id-type="pmid">36062247</pub-id>
                    <pub-id pub-id-type="doi">10.2471/BLT.21.287654</pub-id>
                    <pub-id pub-id-type="pmcid">PMC9421549</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref12">
                <label>12</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Chou</surname>
                            <given-names>W-YS</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Gaysynsky</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Vanderpool</surname>
                            <given-names>RC</given-names>
                        </name>
</person-group>:
                    <article-title>The COVID-19 Misinfodemic: moving beyond fact-checking.</article-title>
                    <source>

                        <italic toggle="yes">Health Educ. Behav.</italic>
</source>
                    <year>2021</year>;<volume>48</volume>(<issue>1</issue>):<fpage>9</fpage>&#x2013;<lpage>13</lpage>.
                    <pub-id pub-id-type="pmid">33322939</pub-id>
                    <pub-id pub-id-type="doi">10.1177/1090198120980675</pub-id>
                    <pub-id pub-id-type="pmcid">PMC8685465</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref13">
                <label>13</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Cusack</surname>
                            <given-names>L</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Del Mar</surname>
                            <given-names>CB</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Chalmers</surname>
                            <given-names>I</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Educational interventions to improve people&#x2019;s understanding of key concepts in assessing the effects of health interventions: a systematic review.</article-title>
                    <source>

                        <italic toggle="yes">Syst. Rev.</italic>
</source>
                    <year>2018</year>;<volume>7</volume>(<issue>1</issue>):<fpage>68</fpage>.
                    <pub-id pub-id-type="pmid">29716639</pub-id>
                    <pub-id pub-id-type="doi">10.1186/s13643-018-0719-4</pub-id>
                    <pub-id pub-id-type="pmcid">PMC5930693</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref14">
                <label>14</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Roozenbeek</surname>
                            <given-names>J</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Linden</surname>
                            <given-names>S</given-names>
                            <prefix>van der</prefix>
                        </name>

                        <name name-style="western">
                            <surname>Goldberg</surname>
                            <given-names>B</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Psychological inoculation improves resilience against misinformation on social media.</article-title>
                    <source>

                        <italic toggle="yes">Sci. Adv.</italic>
</source>
                    <year>2022</year>;<volume>8</volume>(<issue>34</issue>):<fpage>eabo6254</fpage>.
                    <pub-id pub-id-type="doi">10.1126/sciadv.abo6254</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref15">
                <label>15</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Nsangi</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Semakula</surname>
                            <given-names>D</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Rosenbaum</surname>
                            <given-names>SE</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Development of the informed health choices resources in four countries to teach primary school children to assess claims about treatment effects: a qualitative study employing a user-centred approach.</article-title>
                    <source>

                        <italic toggle="yes">Pilot Feasibility Stud.</italic>
</source>
                    <year>2020</year>;<volume>6</volume>(<issue>18</issue>):<fpage>18</fpage>.
                    <pub-id pub-id-type="pmid">32055405</pub-id>
                    <pub-id pub-id-type="doi">10.1186/s40814-020-00565-6</pub-id>
                    <pub-id pub-id-type="pmcid">PMC7008535</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref16">
                <label>16</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Semakula</surname>
                            <given-names>D</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Nsangi</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Oxman</surname>
                            <given-names>M</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Development of mass media resources to improve the ability of parents of primary school children in Uganda to assess the trustworthiness of claims about the effects of treatments: a human-centred design approach.</article-title>
                    <source>

                        <italic toggle="yes">Pilot Feasibility Stud.</italic>
</source>
                    <year>2019</year>;<volume>5</volume>(<issue>1</issue>):<fpage>1</fpage>&#x2013;<lpage>17</lpage>.
                    <pub-id pub-id-type="doi">10.1186/s40814-019-0540-4</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref17">
                <label>17</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Nsangi</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Semakula</surname>
                            <given-names>D</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Oxman</surname>
                            <given-names>AD</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Effects of the Informed Health Choices primary school intervention on the ability of children in Uganda to assess the reliability of claims about treatment effects: a cluster-randomised controlled trial.</article-title>
                    <source>

                        <italic toggle="yes">Lancet.</italic>
</source>
                    <year>2017</year>;<volume>390</volume>(<issue>10092</issue>):<fpage>374</fpage>&#x2013;<lpage>388</lpage>.
                    <pub-id pub-id-type="pmid">28539194</pub-id>
                    <pub-id pub-id-type="doi">10.1016/S0140-6736(17)31226-6</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref18">
                <label>18</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Semakula</surname>
                            <given-names>D</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Nsangi</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Oxman</surname>
                            <given-names>AD</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Effects of the Informed Health Choices podcast on the ability of parents of primary school children in Uganda to assess claims about treatment effects: a randomised controlled trial.</article-title>
                    <source>

                        <italic toggle="yes">Lancet.</italic>
</source>
                    <year>2017</year>;<volume>390</volume>(<issue>10092</issue>):<fpage>389</fpage>&#x2013;<lpage>398</lpage>.
                    <pub-id pub-id-type="pmid">28539196</pub-id>
                    <pub-id pub-id-type="doi">10.1016/S0140-6736(17)31225-4</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref19">
                <label>19</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Nsangi</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Semakula</surname>
                            <given-names>D</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Oxman</surname>
                            <given-names>AD</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Effects of the Informed Health Choices primary school intervention on the ability of children in Uganda to assess the reliability of claims about treatment effects, 1-year follow-up: a cluster-randomised trial.</article-title>
                    <source>

                        <italic toggle="yes">Trials.</italic>
</source>
                    <year>2020</year>;<volume>21</volume>(<issue>1</issue>):<fpage>1</fpage>&#x2013;<lpage>22</lpage>.
                    <pub-id pub-id-type="doi">10.1186/s13063-019-3960-9</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref20">
                <label>20</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Semakula</surname>
                            <given-names>D</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Nsangi</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Oxman</surname>
                            <given-names>AD</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Effects of the Informed Health Choices podcast on the ability of parents of primary school children in Uganda to assess the trustworthiness of claims about treatment effects: one-year follow up of a randomised trial.</article-title>
                    <source>

                        <italic toggle="yes">Trials.</italic>
</source>
                    <year>2020</year>;<volume>21</volume>(<issue>1</issue>).
                    <pub-id pub-id-type="doi">10.1186/s13063-020-4093-x</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref21">
                <label>21</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Austvoll-Dahlgren</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Oxman</surname>
                            <given-names>AD</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Chalmers</surname>
                            <given-names>I</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Key concepts that people need to understand to assess claims about treatment effects.</article-title>
                    <source>

                        <italic toggle="yes">J. Evid. Based Med.</italic>
</source>
                    <year>2015</year>;<volume>8</volume>(<issue>3</issue>):<fpage>112</fpage>&#x2013;<lpage>125</lpage>.
                    <pub-id pub-id-type="pmid">26107552</pub-id>
                    <pub-id pub-id-type="doi">10.1111/jebm.12160</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref22">
                <label>22</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Chalmers</surname>
                            <given-names>I</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Oxman</surname>
                            <given-names>AD</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Austvoll-Dahlgren</surname>
                            <given-names>A</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Key concepts for informed health choices: a framework for helping people learn how to assess treatment claims and make informed choices.</article-title>
                    <source>

                        <italic toggle="yes">BMJ Evid. Based Med.</italic>
</source>
                    <year>2018</year>;<volume>23</volume>(<issue>1</issue>):<fpage>29</fpage>&#x2013;<lpage>33</lpage>.
                    <pub-id pub-id-type="pmid">29367324</pub-id>
                    <pub-id pub-id-type="doi">10.1136/ebmed-2017-110829</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref23">
                <label>23</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Austvoll-Dahlgren</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Semakula</surname>
                            <given-names>D</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Nsangi</surname>
                            <given-names>A</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Measuring ability to assess claims about treatment effects: the development of the 'Claim Evaluation Tools'.</article-title>
                    <source>

                        <italic toggle="yes">BMJ Open.</italic>
</source>
                    <year>2017</year>;<volume>7</volume>(<issue>5</issue>):<fpage>e013184</fpage>.
                    <pub-id pub-id-type="pmid">28515181</pub-id>
                    <pub-id pub-id-type="doi">10.1136/bmjopen-2016-013184</pub-id>
                    <pub-id pub-id-type="pmcid">PMC5777467</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref24">
                <label>24</label>
                <mixed-citation publication-type="other">
                    <collab>Informed Health Choices</collab>:
                    <article-title>Informed Health Choices.</article-title>n.d.
                    <ext-link ext-link-type="uri" xlink:href="https://www.informedhealthchoices.org">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref25">
                <label>25</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Nsangi</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Semakula</surname>
                            <given-names>D</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Glenton</surname>
                            <given-names>C</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Informed health choices intervention to teach primary school children in low-income countries to assess claims about treatment effects: process evaluation.</article-title>
                    <source>

                        <italic toggle="yes">BMJ Open.</italic>
</source>
                    <year>2019</year>;<volume>9</volume>(<issue>9</issue>):<fpage>e030787</fpage>.
                    <pub-id pub-id-type="pmid">31511291</pub-id>
                    <pub-id pub-id-type="doi">10.1136/bmjopen-2019-030787</pub-id>
                    <pub-id pub-id-type="pmcid">PMC6747654</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref26">
                <label>26</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Semakula</surname>
                            <given-names>D</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Nsangi</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Oxman</surname>
                            <given-names>A</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Informed Health Choices media intervention for improving people&#x2019;s ability to critically appraise the trustworthiness of claims about treatment effects: a mixed-methods process evaluation of a randomised trial in Uganda.</article-title>
                    <source>

                        <italic toggle="yes">BMJ Open.</italic>
</source>
                    <year>2019</year>;<volume>9</volume>(<issue>12</issue>):<fpage>e031510</fpage>.
                    <pub-id pub-id-type="pmid">31852697</pub-id>
                    <pub-id pub-id-type="doi">10.1136/bmjopen-2019-031510</pub-id>
                    <pub-id pub-id-type="pmcid">PMC6937069</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref27">
                <label>27</label>
                <mixed-citation publication-type="journal">
                    <article-title>Effects of the Informed Health Choices secondary school intervention on the ability of lower secondary students in Kenya to think critically about health information and choices: Protocol for a cluster-randomized trial.</article-title>
                    <source>

                        <italic toggle="yes">Zenodo.</italic>
</source>
                    <year>2022 [cited November, 2022]</year>.</mixed-citation>
            </ref>
            <ref id="ref28">
                <label>28</label>
                <mixed-citation publication-type="journal">
                    <article-title>Effects of using the Informed Health Choices digital secondary school resources on the ability of Rwandan students to think critically about health: protocol for a cluster-randomised trial.</article-title>
                    <source>

                        <italic toggle="yes">Zenodo.</italic>
</source>
                    <year>2022 [cited November, 2022]</year>.</mixed-citation>
            </ref>
            <ref id="ref29">
                <label>29</label>
                <mixed-citation publication-type="other">
                    <article-title>Does the use of the Informed Health Choices teaching resources improve the secondary students' ability to critically think about health in Uganda? A cluster randomised trial protocol.</article-title>
                    <year>2022 [cited November 2022]</year>.</mixed-citation>
            </ref>
            <ref id="ref30">
                <label>30</label>
                <mixed-citation publication-type="other">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Ssenyonga</surname>
                            <given-names>R</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Lewin</surname>
                            <given-names>S</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Nakyejwe</surname>
                            <given-names>E</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Informed heath choices intervention to teach secondary school adolescents in Uganda to assess claims about treatment effects: a process evaluation protocol.</article-title>
                    <year>2022</year>.
                    <pub-id pub-id-type="doi">10.5281/zenodo.6984730</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref31">
                <label>31</label>
                <mixed-citation publication-type="other">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Mugisha</surname>
                            <given-names>M</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Nyirazinyoye</surname>
                            <given-names>L</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Oxman</surname>
                            <given-names>AD</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Use of the Informed Health Choices digital resources for teaching lower secondary school students in Rwanda to think critically about health: protocol for a process evaluation.</article-title>
                    <year>2022</year>.</mixed-citation>
            </ref>
            <ref id="ref32">
                <label>32</label>
                <mixed-citation publication-type="other">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Chesire</surname>
                            <given-names>F</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Kaseje</surname>
                            <given-names>M</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Ochieng</surname>
                            <given-names>M</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Effect of the Informed Health Choices digital secondary school resources on the ability of lower secondary students in Kenya to critically appraise health claims: protocol for a process evaluation.</article-title>
                    <year>2022 Feb 27, 2023</year>.
                    <ext-link ext-link-type="uri" xlink:href="https://zenodo.org/record/6919372">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref33">
                <label>33</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Rosenbaum</surname>
                            <given-names>S</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Oxman</surname>
                            <given-names>M</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Oxman</surname>
                            <given-names>AD</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Human-centred design development of Informed Health Choices (IHC) learning resources for secondary school students: Protocol.</article-title>
                    <source>

                        <italic toggle="yes">Zenodo.</italic>
</source>
                    <year>2019 2019/12</year>.
                    <ext-link ext-link-type="uri" xlink:href="https://zenodo.org/record/4748446">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref34">
                <label>34</label>
                <mixed-citation publication-type="book">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Rosenbaum</surname>
                            <given-names>SE</given-names>
                        </name>
</person-group>:
                    <source>

                        <italic toggle="yes">Improving the user experience of evidence: A design approach to evidence-informed health care.</italic>
</source>
                    <publisher-loc>Oslo</publisher-loc>:
                    <publisher-name>Arkitektur- og designh&#x00f8;gskolen i Oslo</publisher-name>;<year>2010</year>.</mixed-citation>
            </ref>
            <ref id="ref35">
                <label>35</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Giacomin</surname>
                            <given-names>J</given-names>
                        </name>
</person-group>:
                    <article-title>What is Human Centred Design?</article-title>
                    <source>

                        <italic toggle="yes">Des. J.</italic>
</source>
                    <year>2014</year>;<volume>17</volume>(<issue>4,2014</issue>):<fpage>606</fpage>&#x2013;<lpage>623</lpage>.
                    <pub-id pub-id-type="doi">10.2752/175630614X14056185480186</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref36">
                <label>36</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Melles</surname>
                            <given-names>M</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Albayrak</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Goossens</surname>
                            <given-names>R</given-names>
                        </name>
</person-group>:
                    <article-title>Innovating health care: key characteristics of human-centered design.</article-title>
                    <source>

                        <italic toggle="yes">Int. J. Qual. Health Care.</italic>
</source>
                    <year>2021</year>;<volume>33</volume>(<issue>Supplement_1</issue>):<fpage>37</fpage>&#x2013;<lpage>44</lpage>.
                    <pub-id pub-id-type="pmid">33068104</pub-id>
                    <pub-id pub-id-type="doi">10.1093/intqhc/mzaa127</pub-id>
                    <pub-id pub-id-type="pmcid">PMC7802070</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref37">
                <label>37</label>
                <mixed-citation publication-type="other">
                    <collab>ISO</collab>:
                    <source>

                        <italic toggle="yes">Ergonomics of human-system interaction &#x2014; Part 210: Human-centred design for interactive systems.</italic>
</source>
                    <publisher-loc>Geneva</publisher-loc>:<year>2019</year>.</mixed-citation>
            </ref>
            <ref id="ref38">
                <label>38</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Nsangi</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Oxman</surname>
                            <given-names>AD</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Oxman</surname>
                            <given-names>M</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Protocol for assessing stakeholder engagement in the development and evaluation of the Informed Health Choices resources teaching secondary school students to think critically about health claims and choices.</article-title>
                    <source>

                        <italic toggle="yes">PLoS One.</italic>
</source>
                    <year>2020</year>;<volume>15</volume>(<issue>10</issue>):<fpage>e0239985</fpage>.
                    <pub-id pub-id-type="pmid">33045009</pub-id>
                    <pub-id pub-id-type="doi">10.1371/journal.pone.0239985</pub-id>
                    <pub-id pub-id-type="pmcid">PMC7549807</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref39">
                <label>39</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Chesire</surname>
                            <given-names>F</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Ochieng</surname>
                            <given-names>M</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Mugisha</surname>
                            <given-names>M</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Contextualizing critical thinking about health using digital technology in secondary schools in Kenya: a qualitative analysis.</article-title>
                    <source>

                        <italic toggle="yes">Pilot Feasibility Stud.</italic>
</source>
                    <year>2022</year>;<volume>8</volume>(<issue>1</issue>):<fpage>227</fpage>.
                    <pub-id pub-id-type="pmid">36203201</pub-id>
                    <pub-id pub-id-type="doi">10.1186/s40814-022-01183-0</pub-id>
                    <pub-id pub-id-type="pmcid">PMC9535840</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref40">
                <label>40</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Mugisha</surname>
                            <given-names>M</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Uwitonze</surname>
                            <given-names>AM</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Chesire</surname>
                            <given-names>F</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Teaching critical thinking about health using digital technology in lower secondary schools in Rwanda: A qualitative context analysis.</article-title>
                    <source>

                        <italic toggle="yes">PLoS One.</italic>
</source>
                    <year>2021</year>;<volume>16</volume>(<issue>3</issue>):<fpage>e0248773</fpage>.
                    <pub-id pub-id-type="pmid">33750971</pub-id>
                    <pub-id pub-id-type="doi">10.1371/journal.pone.0248773</pub-id>
                    <pub-id pub-id-type="pmcid">PMC7984628</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref41">
                <label>41</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Ssenyonga</surname>
                            <given-names>R</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Sewankambo</surname>
                            <given-names>NK</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Mugagga</surname>
                            <given-names>SK</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Learning to think critically about health using digital technology in Ugandan lower secondary schools: A contextual analysis.</article-title>
                    <source>

                        <italic toggle="yes">PLoS One.</italic>
</source>
                    <year>2022</year>;<volume>17</volume>(<issue>2</issue>):<fpage>e0260367</fpage>.
                    <pub-id pub-id-type="pmid">35108268</pub-id>
                    <pub-id pub-id-type="doi">10.1371/journal.pone.0260367</pub-id>
                    <pub-id pub-id-type="pmcid">PMC8809610</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref42">
                <label>42</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Michie</surname>
                            <given-names>S</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Van Stralen</surname>
                            <given-names>MM</given-names>
                        </name>

                        <name name-style="western">
                            <surname>West</surname>
                            <given-names>R</given-names>
                        </name>
</person-group>:
                    <article-title>The behaviour change wheel: a new method for characterising and designing behaviour change interventions.</article-title>
                    <source>

                        <italic toggle="yes">Implement. Sci.</italic>
</source>
                    <year>2011</year>;<volume>6</volume>(<issue>1</issue>):<fpage>1</fpage>&#x2013;<lpage>12</lpage>.</mixed-citation>
            </ref>
            <ref id="ref43">
                <label>43</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Agaba</surname>
                            <given-names>JJ</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Chesire</surname>
                            <given-names>F</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Mugisha</surname>
                            <given-names>M</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Prioritisation of Informed Health Choices (IHC) key concepts to be included in lower secondary school resources: A consensus study.</article-title>
                    <source>

                        <italic toggle="yes">PLoS One.</italic>
</source>
                    <year>2023</year>;<volume>18</volume>(<issue>4</issue>):<fpage>e0267422</fpage>.
                    <pub-id pub-id-type="pmid">37027357</pub-id>
                    <pub-id pub-id-type="doi">10.1371/journal.pone.0267422</pub-id>
                    <pub-id pub-id-type="pmcid">PMC10081733</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref44">
                <label>44</label>
                <mixed-citation publication-type="book">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Oxman</surname>
                            <given-names>AD</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Dahlgren</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Garc&#x00ed;a</surname>
                            <given-names>LM</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <source>

                        <italic toggle="yes">The effects of teaching strategies on learning to think critically in primary and secondary schools: protocol for an overview of systematic reviews.</italic>
</source>
                    <publisher-name>Norwegian Institute of Public Health</publisher-name>;<year>2019</year>.</mixed-citation>
            </ref>
            <ref id="ref45">
                <label>45</label>
                <mixed-citation publication-type="other">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Moberg</surname>
                            <given-names>J</given-names>
                        </name>
</person-group>:
                    <article-title>Creating an examples collection for the &#x201c;Be Smart About Your Health&#x201d; resources: part of the CHOICE project.</article-title>
                    <year>2023</year>.
                    <pub-id pub-id-type="doi">10.5281/zenodo.7702264</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref46">
                <label>46</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Birt</surname>
                            <given-names>L</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Scott</surname>
                            <given-names>S</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Cavers</surname>
                            <given-names>D</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Member checking: a tool to enhance trustworthiness or merely a nod to validation?</article-title>
                    <source>

                        <italic toggle="yes">Qual. Health Res.</italic>
</source>
                    <year>2016</year>;<volume>26</volume>(<issue>13</issue>):<fpage>1802</fpage>&#x2013;<lpage>1811</lpage>.
                    <pub-id pub-id-type="doi">10.1177/1049732316654870</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref47">
                <label>47</label>
                <mixed-citation publication-type="data">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Rosenbaum</surname>
                            <given-names>S</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <data-title>Dataset for &#x201c;Teaching critical thinking about health information and choices in secondary schools: human-centred design of digital resources&#x201d;.</data-title>[Data set].
                    <source>

                        <italic toggle="yes">Zenodo.</italic>
</source>
                    <year>2023</year>.
                    <pub-id pub-id-type="doi">10.5281/zenodo.7695782</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref48">
                <label>48</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Rosenbaum</surname>
                            <given-names>S</given-names>
                        </name>

                        <etal/>
</person-group>:
Extended dataset and Coreq Checklist for "Teaching critical thinking about health information and choices in secondary schools: human-centred design of digital resources".
                    <source>

                        <italic toggle="yes">Zenodo.</italic>
</source>
                    <year>2023</year>.
                    <pub-id pub-id-type="doi">10.5281/zenodo.7806139</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref49">
                <label>49</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Charters</surname>
                            <given-names>E</given-names>
                        </name>
</person-group>:
                    <article-title>The use of think-aloud methods in qualitative research an introduction to think-aloud methods.</article-title>
                    <source>

                        <italic toggle="yes">Brock Educ. J.</italic>
</source>
                    <year>2003</year>;<volume>12</volume>(<issue>2</issue>).
                    <pub-id pub-id-type="doi">10.26522/brocked.v12i2.38</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref50">
                <label>50</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Ericsson</surname>
                            <given-names>K</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Simon</surname>
                            <given-names>HA</given-names>
                        </name>
</person-group>:
                    <article-title>Verbal reports as data.</article-title>
                    <source>

                        <italic toggle="yes">Psychol. Rev.</italic>
</source>
                    <year>1980</year>;<volume>87</volume>(<issue>3</issue>):<fpage>215</fpage>&#x2013;<lpage>251</lpage>.
                    <pub-id pub-id-type="doi">10.1037/0033-295X.87.3.215</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref51">
                <label>51</label>
                <mixed-citation publication-type="book">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Kuniavsky</surname>
                            <given-names>M</given-names>
                        </name>
</person-group>:
                    <source>

                        <italic toggle="yes">Observing the User Experience: A Practitioner's Guide to User Research.</italic>
</source>
                    <edition>1 ed.</edition>
                    <person-group person-group-type="editor">

                        <name name-style="western">
                            <surname>Kaufmann</surname>
                            <given-names>M</given-names>
                        </name>
</person-group>, editor.
                    <publisher-name>Morgan Kaufmann</publisher-name>;<year>2003</year>;<fpage>575</fpage>p.</mixed-citation>
            </ref>
            <ref id="ref52">
                <label>52</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Dahlgren</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Semakula</surname>
                            <given-names>D</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Chesire</surname>
                            <given-names>F</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Critical thinking about treatment effects in Eastern Africa: development and Rasch analysis of an assessment tool.</article-title>
                    <source>

                        <italic toggle="yes">F1000Research.</italic>
</source>
                    <year>2023</year>;<volume>12</volume>:<fpage>887</fpage>.</mixed-citation>
            </ref>
            <ref id="ref53">
                <label>53</label>
                <mixed-citation publication-type="other">
                    <collab>Informed Health Choices project</collab>:
                    <article-title>Be Smart About Your Health 2022 [Educational resources].</article-title>
                    <ext-link ext-link-type="uri" xlink:href="https://besmarthealth.org/">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref54">
                <label>54</label>
                <mixed-citation publication-type="other">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Agaba</surname>
                            <given-names>JJ</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Chesire</surname>
                            <given-names>F</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Michael</surname>
                            <given-names>M</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Prioritisation of Informed Health Choices (IHC) Key Concepts to be included in lower-secondary school resources: a consensus study.</article-title>
                    <year>2022</year>.</mixed-citation>
            </ref>
            <ref id="ref55">
                <label>55</label>
                <mixed-citation publication-type="other">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Chesire</surname>
                            <given-names>F</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Kaseje</surname>
                            <given-names>M</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Ochieng</surname>
                            <given-names>M</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Effect of the Informed Health Choices digital secondary school resources on the ability of lower secondary students in Kenya to critically appraise health claims: protocol for a process evaluation.</article-title>
                    <year>2022</year>.</mixed-citation>
            </ref>
            <ref id="ref56">
                <label>56</label>
                <mixed-citation publication-type="other">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Oxman</surname>
                            <given-names>M</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Oxman</surname>
                            <given-names>AD</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Fretheim</surname>
                            <given-names>A</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Participants' and investigators' experiences and views of potential adverse effects of an educational intervention: Protocol for a qualitative evidence synthesis (Version 1).</article-title>
                    <year>2023</year>.
                    <pub-id pub-id-type="doi">10.5281/zenodo.7681365</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref57">
                <label>57</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Voogt</surname>
                            <given-names>J</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Roblin</surname>
                            <given-names>NP</given-names>
                        </name>
</person-group>:
                    <article-title>A comparative analysis of international frameworks for 21st century competences: Implications for national curriculum policies.</article-title>
                    <source>

                        <italic toggle="yes">J. Curric. Stud.</italic>
</source>
                    <year>2012</year>;<volume>44</volume>(<issue>3</issue>):<fpage>299</fpage>&#x2013;<lpage>321</lpage>.
                    <pub-id pub-id-type="doi">10.1080/00220272.2012.668938</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref58">
                <label>58</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Abrami</surname>
                            <given-names>PC</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Bernard</surname>
                            <given-names>RM</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Borokhovski</surname>
                            <given-names>E</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Strategies for teaching students to think critically: A meta-analysis.</article-title>
                    <source>

                        <italic toggle="yes">Rev. Educ. Res.</italic>
</source>
                    <year>2015</year>;<volume>85</volume>(<issue>2</issue>):<fpage>275</fpage>&#x2013;<lpage>314</lpage>.
                    <pub-id pub-id-type="doi">10.3102/0034654314551063</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref59">
                <label>59</label>
                <mixed-citation publication-type="other">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Rodriguez-Segura</surname>
                            <given-names>D</given-names>
                        </name>
</person-group>:
                    <article-title>Educational technology in developing countries: A systematic review. University of Virginia EdPolicy Works Working Papers.</article-title>
                    <year>2020</year>.
                    <ext-link ext-link-type="uri" xlink:href="https://curryvirginiaedu/sites/default/files/uploads/epw/72_Edtech_in_Developing_Countries.pdf">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref60">
                <label>60</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Gerard</surname>
                            <given-names>L</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Matuk</surname>
                            <given-names>C</given-names>
                        </name>

                        <name name-style="western">
                            <surname>McElhaney</surname>
                            <given-names>K</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Automated, adaptive guidance for K-12 education.</article-title>
                    <source>

                        <italic toggle="yes">Educ. Res. Rev.</italic>
</source>
                    <year>2015</year>;<volume>15</volume>:<fpage>41</fpage>&#x2013;<lpage>58</lpage>.
                    <pub-id pub-id-type="doi">10.1016/j.edurev.2015.04.001</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref61">
                <label>61</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Xu</surname>
                            <given-names>Z</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Wijekumar</surname>
                            <given-names>K</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Ramirez</surname>
                            <given-names>G</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>The effectiveness of intelligent tutoring systems on K-12 students' reading comprehension: A meta-analysis.</article-title>
                    <source>

                        <italic toggle="yes">Br. J. Educ. Technol.</italic>
</source>
                    <year>2019</year>;<volume>50</volume>(<issue>6</issue>):<fpage>3119</fpage>&#x2013;<lpage>3137</lpage>.
                    <pub-id pub-id-type="doi">10.1111/bjet.12758</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref62">
                <label>62</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Ma</surname>
                            <given-names>W</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Adesope</surname>
                            <given-names>OO</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Nesbit</surname>
                            <given-names>JC</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Intelligent tutoring systems and learning outcomes: A meta-analysis.</article-title>
                    <source>

                        <italic toggle="yes">J. Educ. Psychol.</italic>
</source>
                    <year>2014</year>;<volume>106</volume>(<issue>4</issue>):<fpage>901</fpage>&#x2013;<lpage>918</lpage>.
                    <pub-id pub-id-type="doi">10.1037/a0037123</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref63">
                <label>63</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Steenbergen-Hu</surname>
                            <given-names>S</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Cooper</surname>
                            <given-names>H</given-names>
                        </name>
</person-group>:
                    <article-title>A meta-analysis of the effectiveness of intelligent tutoring systems on K&#x2013;12 students&#x2019; mathematical learning.</article-title>
                    <source>

                        <italic toggle="yes">J. Educ. Psychol.</italic>
</source>
                    <year>2013</year>;<volume>105</volume>(<issue>4</issue>):<fpage>970</fpage>&#x2013;<lpage>987</lpage>.
                    <pub-id pub-id-type="doi">10.1037/a0032447</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref64">
                <label>64</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Chesire</surname>
                            <given-names>F</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Mugisha</surname>
                            <given-names>M</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Ssenyonga</surname>
                            <given-names>R</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Effects of the Informed Health Choices secondary school intervention: A prospective meta-analysis.</article-title>
                    <source>

                        <italic toggle="yes">J. Evid. Based Med.</italic>
</source>
                    <year>2023</year>;<volume>16</volume>(<issue>3</issue>):<fpage>321</fpage>&#x2013;<lpage>331</lpage>.
                    <pub-id pub-id-type="pmid">37735807</pub-id>
                    <pub-id pub-id-type="doi">10.1111/jebm.12552</pub-id>
                </mixed-citation>
            </ref>
        </ref-list>
    </back>
    <sub-article article-type="reviewer-report" id="report250510">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.163450.r250510</article-id>
            <title-group>
                <article-title>Reviewer response for version 2</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Baur</surname>
                        <given-names>Cynthia</given-names>
                    </name>
                    <xref ref-type="aff" rid="r250510a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0003-1793-7046</uri>
                </contrib>
                <aff id="r250510a1">
                    <label>1</label>University of Maryland at College Park, College Park, Maryland, USA</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>14</day>
                <month>5</month>
                <year>2024</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2024 Baur C</copyright-statement>
                <copyright-year>2024</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport250510" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.132580.2"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>The authors provide a detailed description of a multi-phase and multi-step process to develop and test learning modules about health information and health choices for children aged 13-16 in Kenya, Rwanda, and Uganda. The project was developed and tested in partnership with many stakeholders in the three countries. The Introduction opens with a brief discussion of the many challenges of identifying accurate information but ends with a purpose statement that the article will describe the development of the learning modules. The rest of the paper is about the module development process with Methods and Results being about the modules and learning techniques. Although the paper includes a discussion of teaching strategies in the Results section, what is missing is a theory of learning and expected results that would help explain why the team chose the human-centered design approach that it did, along with some literature justifying this choice. The paper provides a lot of detail about how a human-centered design approach collects feedback and iterates prototypes, but I am unclear why a human-centered design approach was necessary to produce this set of modules. I am also unclear about the lessons the authors want to impart to readers. Should we always use a human-centered design approach for health curriculum for children of these ages? Under what conditions or purposes might a different approach be better? Instead of naming the products developed as the primary results, I expected to read about how well or not a human-centered approach had worked to produce these products. I also lost the thread of what happened to all the interview, group discussion and stakeholder data. The authors provide a rich description of their development process, but I'm not sure what they intend for readers to take away from this report of their process and products.</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Partly</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Not applicable</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Partly</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Reviewer Expertise:</p>
            <p>Health literacy, health communication, risk communication</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
        <sub-article article-type="response" id="comment12306-250510">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Rosenbaum</surname>
                            <given-names>Sarah</given-names>
                        </name>
                        <aff>Norwegian Institute of Public Health, Norway</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>26</day>
                    <month>8</month>
                    <year>2024</year>
                </pub-date>
            </front-stub>
            <body>
                <p>Peer review 2 and our corresponding responses:</p>
                <p> </p>
                <p> 
                    <bold>1) PEER REVIEW: </bold>The Introduction opens with a brief discussion of the many challenges of identifying accurate information but ends with a purpose statement that the article will describe the development of the learning modules. Although the paper includes a discussion of teaching strategies in the Results section, what is missing is a theory of learning and expected results that would help explain why the team chose the human-centered design approach that it did, along with some literature justifying this choice. The paper provides a lot of detail about how a human-centered design approach collects feedback and iterates prototypes, but I am unclear why a human-centered design approach was necessary to produce this set of modules.</p>
                <p> 
                    <bold>RESPONSE:&#x00a0;</bold>I agree that addressing this would improve the manuscript, and have added three new sections to the Discussion: &#x201c;Reflections about learning theory&#x201d;, &#x201c;Why a human-centred design approach&#x201d;, and &#x201c;Strengths and limitations of the human-centred design approach&#x201d;, as well as a number of new references.</p>
                <p> </p>
                <p> 
                    <bold>2) PEER REVIEW: </bold>I am also unclear about the lessons the authors want to impart to readers. The authors provide a rich description of their development process, but I'm not sure what they intend for readers to take away from this report of their process and products.</p>
                <p> 
                    <bold>RESPONSE: </bold>See response #4 below about results.</p>
                <p> </p>
                <p> </p>
                <p> 
                    <bold>3)&#x00a0;PEER REVIEW: </bold>Should we always use a human-centered design approach for health curriculum for children of these ages? Under what conditions or purposes might a different approach be better?</p>
                <p> 
                    <bold>RESPONSE:&#x00a0;</bold>Educating young people in low-resource school settings to think critically about health choices is a complex problem. Developing instructional material for simpler and more well-defined learning tasks might be approached by less resource-intensive methods. I have added a text elaborating on this issue under Discussion: &#x201c;Why a human-centred design approach&#x201d;.</p>
                <p> </p>
                <p> </p>
                <p> 
                    <bold>4) PEER REVIEW: </bold>Instead of naming the products developed as the primary results, I expected to read about how well or not a human-centered approach had worked to produce these products.</p>
                <p> 
                    <bold>RESPONSE:&#x00a0;</bold>&#x201c;Results&#x201d; are not only what we found when collecting and analysing data, but also the final solution we created and the noteworthy design decisions we made along the way. These three types of findings can be of interest to a range of readers: people who are designing educational resources based on IHC Key Concepts, people who are designing related educational resources, such as for teaching critical thinking or for use in low-resource learning environments, or people interested in the design approach more generally within the context of a research inquiry.</p>
                <p> However, I agree that we could have also included more explicit findings related to the human-centred design approach. Bazzano et al (2020) proposed a reporting guideline when reporting health research involving design that suggests reporting the following from design activities in the results section: 
                    <list list-type="bullet">
                        <list-item>
                            <p>What was designed</p>
                        </list-item>
                        <list-item>
                            <p>Summary of major insights or reflections from the design process</p>
                        </list-item>
                        <list-item>
                            <p>Description of decisions made during the design process</p>
                        </list-item>
                    </list> The guidance also suggests reflecting on the application of design to the work, including strengths and limitations. I have added a completed guidance checklist to the Extended data set, which indicates where in the manuscript each item can be found. Additionally, I am making the following changes to the manuscript:</p>
                <p> </p>
                <p> "Results" section changes:
                    <bold> </bold> 
                    <list list-type="bullet">
                        <list-item>
                            <p>Made changes to the 1st paragraph in Results section to more clearly indicate the type of results we are reporting</p>
                        </list-item>
                        <list-item>
                            <p>Added heading and text: &#x201c;Other noteworthy design decisions&#x201d;</p>
                        </list-item>
                        <list-item>
                            <p>Made changes to some subheadings in the Results sections</p>
                        </list-item>
                        <list-item>
                            <p>Made changes to some column headings in Tables 9-13, to clarify where results about "design decisions" could be found</p>
                        </list-item>
                    </list> "Discussion" section changes: 
                    <list list-type="bullet">
                        <list-item>
                            <p>Added &#x201c;Strengths and limitations of the human-centred design approach for this work&#x201d;</p>
                        </list-item>
                    </list> </p>
                <p> "Conclusion"&#x00a0;section changes 
                    <list list-type="bullet">
                        <list-item>
                            <p>Adjusted text to differentiate more clearly between the three types of results</p>
                        </list-item>
                    </list> </p>
                <p> 
                    <bold>5) PEER REVIEW:&#x00a0;</bold>I also lost the thread of what happened to all the interview, group discussion and stakeholder data.</p>
                <p> 
                    <bold>RESPONSE:&#x00a0;</bold>Our data is published on Zenodo. See list of data &#x201c;Underlying data&#x201d;, reference 47. However, I acknowledge that the documentation of a project of this nature can be difficult to follow. Therefore I&#x2019;ve added content to the Discussion addressing this under the heading: 
                    <list list-type="bullet">
                        <list-item>
                            <p>&#x00a0;&#x201c;Strengths and limitations of the human-centred design approach&#x201d;</p>
                        </list-item>
                    </list>
                </p>
            </body>
        </sub-article>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report250515">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.145511.r250515</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Mathews</surname>
                        <given-names>Catherine</given-names>
                    </name>
                    <xref ref-type="aff" rid="r250515a1">1</xref>
                    <role>Referee</role>
                </contrib>
                <aff id="r250515a1">
                    <label>1</label>South African Medical Research Council, Cape Town, South Africa</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>5</day>
                <month>9</month>
                <year>2024</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2024 Mathews C</copyright-statement>
                <copyright-year>2024</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport250515" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.132580.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>This manuscript describes the processes undertaken to develop a set of digital learning resources to teach students in Kenyan, Rwandan and Ugandan schools to think critically about health and health care, and to develop skills to assess the reliability of claims about interventions to improve health.&#x00a0;</p>
            <p> Interventions to teach critical thinking are seldom included in the curricula of schools in the countries in which this research was conducted, despite that critical thinking is recognized as a valuable skill for young people to acquire, which will help them make decisions through the life course.&#x00a0; In the countries in which the research was conducted, and in many other countries, teachers lack skills and resources to enable them to teach critical thinking.</p>
            <p> Both the intervention and the measure selected to evaluate the effects of the intervention are based on a large body of sound research which is referenced in the manuscript.</p>
            <p> The manuscript provides valuable information about how to use a human-centered design approach to adapt a program that promotes critical thinking about health and to adapt measures to evaluate the program.&#x00a0;&#x00a0;Stakeholders contributed to the intervention development process is described in sufficient detail and is appropriate.&#x00a0; The changes made to the interventions in response to stakeholders&#x2019; input are detailed. The problems identified during the design process, and the actions taken to address such problems indicate how feedback from stakeholders was used to inform the development cycles of the intervention.&#x00a0;</p>
            <p> The description of the set of lessons is clear and valuable and together with information about the key concepts that were taught in a sample lesson helps the reader gain more information about the intervention.</p>
            <p> The manuscript is written clearly, and the research processes are described comprehensively. It is rare to read a manuscript in which the intervention development process is set out systematically and clearly. The manuscript is excellent, and I do not have any suggestions for improvement.</p>
            <p> 
                <bold>Major points</bold>
            </p>
            <p> None</p>
            <p> 
                <bold>Minor points</bold>
            </p>
            <p> None</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Yes</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Not applicable</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Yes</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Yes</p>
            <p>Reviewer Expertise:</p>
            <p>Sexual and reproductive health</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.</p>
        </body>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report173757">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.145511.r173757</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Steckelberg</surname>
                        <given-names>Anke</given-names>
                    </name>
                    <xref ref-type="aff" rid="r173757a1">1</xref>
                    <role>Referee</role>
                </contrib>
                <aff id="r173757a1">
                    <label>1</label>Interdisciplinary Center for Health Sciences, Institute of Health and Nursing Science, Martin-Luther-Universitat Halle-Wittenberg, Halle (Saale), Saxony-Anhalt, Germany</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>1</day>
                <month>6</month>
                <year>2023</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2023 Steckelberg A</copyright-statement>
                <copyright-year>2023</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport173757" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.132580.1"/>
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                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>The authors reported the development of digital resources to teach secondary school students applying a human-centred design. This project is part of a larger project comprising extensive exploration of stakeholders perspectives and contexts and also systematic reviews of teaching methods in the beginning of the project to inform this present study which will then be evaluated in randomized controlled trials in three countries in Africa.</p>
            <p> </p>
            <p> In order to enhance readability and help readers to understand the complexity of the whole project, authors reported details that had already been published elsewhere.</p>
            <p> </p>
            <p> This study is highly relevant and it was great to have access to the website. The manuscript is well written. However, authors should rather refer to already available publications and instead should provide further information on the following aspects: 
                <list list-type="order">
                    <list-item>
                        <p>The conducted
                            <italic> &#x201c;Individual interviews employing user testing methods&#x201d; </italic>comprised three parts. Some teachers were interviewed right after a pilot lesson, so they had their experiences from the lesson fresh in mind. Please add information how many of them already taught a pilot lesson before the interview and whether these teachers also had access to the teachers guide.</p>
                    </list-item>
                    <list-item>
                        <p>Piloting and observation: The authors reported that early pilots involved single lessons. Were all lessons piloted as single lessons?</p>
                    </list-item>
                    <list-item>
                        <p>&#x00a0;The authors translated several&#x00a0;of the audio recordings from individual and group interviews. Please add information on the selection of the recordings and why it was done.</p>
                    </list-item>
                    <list-item>
                        <p>The authors provide a teacher`s guide and also reported that lack of competences was a relevant issue. Please clarify whether participation in the workshop for teachers was optional or mandatory and whether teachers competences were assessed.</p>
                    </list-item>
                </list>
            </p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Yes</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Not applicable</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Yes</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Reviewer Expertise:</p>
            <p>Critical health literacy, evidence-based health information, informed shared decision making</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
        <sub-article article-type="response" id="comment11208-173757">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Rosenbaum</surname>
                            <given-names>Sarah</given-names>
                        </name>
                        <aff>Norwegian Institute of Public Health, Norway</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>6</day>
                    <month>3</month>
                    <year>2024</year>
                </pub-date>
            </front-stub>
            <body>
                <p>
                    <bold>Response to Peer reviewer #1</bold>
                </p>
                <p> Thank you very much for your time reviewing this article and your constructive questions. I am answering them below and updating the manuscript at the same time.</p>
                <p> </p>
                <p> 
                    <bold>Question 1: The conducted
                        <italic>&#x00a0;&#x201c;Individual interviews employing user testing methods&#x201d;&#x00a0;</italic>comprised three parts. Some teachers were interviewed right after a pilot lesson, so they had their experiences from the lesson fresh in mind. Please add information how many of them already taught a pilot lesson before the interview and whether these teachers also had access to the teachers guide.</bold>
                </p>
                <p> </p>
                <p> 
                    <italic>Reply 1a &amp; b:</italic>
                </p>
                <p> 
                    <bold>1a: How many taught a pilot lesson before the interview:</bold> I&#x2019;ve made changes to Table 6 so that this information is added there. I did this by rechecking with the PhD fellows about the participant data, and we found small errors in the original table, so these are also fixed.</p>
                <p> 
                    <bold>1b: Whether teachers had access to the teachers guide: </bold>In the first development phase, we had not begun work on the teacher's guide, so no teachers had access to this in the early interviews or pilots. Regarding the second development phase, I&#x2019;ve edited the text in the paragraph &#x201c;Piloting and observation&#x201d; so that the following information is provided: &#x201c;In the final pilot, teachers taught all the lessons over a school term, with access to a complete prototype of the resources including the teacher&#x2019;s guide.&#x201d;</p>
                <p> </p>
                <p> 
                    <bold>Question 2: Piloting and observation: The authors reported that early pilots involved single lessons. Were all lessons piloted as single lessons?</bold>
                </p>
                <p> </p>
                <p> 
                    <italic>Reply 2:</italic>
                </p>
                <p> No. I have added the following clarifying text under &#x201c;Piloting and observation&#x201d;:</p>
                <p> &#x201c;Initially we sought to try out different approaches to overarching questions that were not lesson specific (e.g. how much content, what kind of lesson structure, what kind of teaching strategies to build on, how to format the materials). As we made formatting and content decisions, we gradually developed a full set of lessons, not all of which were piloted individually in the the first development phase."</p>
                <p> 
                    <bold>Question 3: The authors translated several&#x00a0;of the audio recordings from individual and group interviews. Please add information on the selection of the recordings and why it was done.</bold>
                    <bold> </bold>
                </p>
                <p> </p>
                <p> 
                    <italic>Reply 3:</italic>
                </p>
                <p> I changed the text in the first paragraph under &#x201c;Data analysis&#x201d; to reflect more accurately what was done in each country: &#x201c;In Uganda and Kenya, all interviews were carried out in English and transcribed. In Rwanda, interviews were carried out in Kinyarwanda and transcribed in English. There, the PhD fellow and research assistant relied on notes they made during interview sessions, and selected some recordings to review when further clarification of their notes was needed.&#x201d;</p>
                <p> 
                    <bold>Question 4: The authors provide a teacher`s guide and also reported that lack of competences was a relevant issue. Please clarify whether participation in the workshop for teachers was optional or mandatory and whether teachers competences were assessed.</bold>
                </p>
                <p> </p>
                <p> 
                    <italic>Reply:</italic>
                </p>
                <p> The workshop was a part of the intervention that was tested in three randomised trials evaluating the effect of these resources, and reported in those studies. Participation in the workshop was not mandatory. Teachers&#x2019; competences were not assessed at the end of the workshop, but they were assessed in the trials at the end of all the lessons. You can find the trial results for both students and teachers in Table 3 of this article:
                    <bold> </bold>Effects of the Informed Health Choices secondary school intervention: A prospective meta-analysis: &#x00a0;
                    <ext-link ext-link-type="uri" xlink:href="https://onlinelibrary.wiley.com/doi/10.1111/jebm.12552">https://onlinelibrary.wiley.com/doi/10.1111/jebm.12552</ext-link>
                </p>
                <p> I have added the following short summary of the results of this prospective meta-analysis in the Conclusions section, along with the corresponding citation reference: &#x201c;A Prospective meta-analysis synthesizing the results of the three randomised trials has shown that the resources led to a large improvement in the ability of students and teachers to think critically about health choices, though only 42% of students achieved a passing score[64]. Next research steps are well underway: process evaluations of the three trials and one-year follow up studies.&#x201d;</p>
                <p> 
                    <bold>Other updates to reflect referenced studies that are now published:</bold> 
                    <list list-type="bullet">
                        <list-item>
                            <p>Reference #52 has been updated as this article has now been published.</p>
                        </list-item>
                        <list-item>
                            <p>Reference #64 in the Conclusion is new, as the trial results are now published.</p>
                        </list-item>
                    </list>
                </p>
            </body>
        </sub-article>
    </sub-article>
</article>
