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    <front>
        <journal-meta>
            <journal-id journal-id-type="pmc">F1000Research</journal-id>
            <journal-title-group>
                <journal-title>F1000Research</journal-title>
            </journal-title-group>
            <issn pub-type="epub">2046-1402</issn>
            <publisher>
                <publisher-name>F1000 Research Limited</publisher-name>
                <publisher-loc>London, UK</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="doi">10.12688/f1000research.130532.2</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Data Note</subject>
                </subj-group>
                <subj-group>
                    <subject>Articles</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Sociodemographic and clinical characteristics of hospital admissions for COVID-19: A retrospective cohort of patients in two hospitals in the south of Brazil</article-title>
                <fn-group content-type="pub-status">
                    <fn>
                        <p>[version 2; peer review: 1 approved, 1 approved with reservations]</p>
                    </fn>
                </fn-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author" corresp="yes">
                    <name>
                        <surname>Jesus</surname>
                        <given-names>Edna Ribeiro de</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0001-8699-8972</uri>
                    <xref ref-type="corresp" rid="c1">a</xref>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Boell</surname>
                        <given-names>Julia Estela Willrich</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Reckziegel</surname>
                        <given-names>Juliana Cristina Lessmann</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Project Administration</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Vaz</surname>
                        <given-names>Rafael Sittoni</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <xref ref-type="aff" rid="a2">2</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Goulart</surname>
                        <given-names>Marco Aur&#x00e9;lio</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <xref ref-type="aff" rid="a2">2</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Peluso</surname>
                        <given-names>Fl&#x00e1;via Marin</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <xref ref-type="aff" rid="a2">2</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Nogueira</surname>
                        <given-names>Tiago da Cruz</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <xref ref-type="aff" rid="a2">2</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>&#x00c1;vila</surname>
                        <given-names>M&#x00e1;rcio Costa Silveira de</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <xref ref-type="aff" rid="a3">3</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Malkiewiez</surname>
                        <given-names>Michelle Mariah</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Schmidt</surname>
                        <given-names>Catiele Raquel</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0001-7711-4370</uri>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Weissenberg</surname>
                        <given-names>Vanessa Cruz Corr&#x00ea;a</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <xref ref-type="aff" rid="a2">2</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Piccolin</surname>
                        <given-names>Millena Maria</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <xref ref-type="aff" rid="a4">4</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Char&#x00e3;o Junior</surname>
                        <given-names>Walmiro Martins</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Project Administration</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <xref ref-type="aff" rid="a5">5</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Lorenzini</surname>
                        <given-names>Elisiane</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Funding Acquisition</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Project Administration</role>
                    <role content-type="http://credit.niso.org/">Resources</role>
                    <role content-type="http://credit.niso.org/">Software</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0001-8426-2080</uri>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <aff id="a1">
                    <label>1</label>Federal University of Santa Catarina, Florian&#x00f3;polis, Santa Catarina, Brazil</aff>
                <aff id="a2">
                    <label>2</label>Tereza Ramos General Hospital and Maternity, Lages, Santa Catarina, Brazil</aff>
                <aff id="a3">
                    <label>3</label>Federal University of Planalto Catarinense, Lages, Santa Catarina, Brazil</aff>
                <aff id="a4">
                    <label>4</label>Faculty of Santa Catarina, Florian&#x00f3;polis, Santa Catarina, Brazil</aff>
                <aff id="a5">
                    <label>5</label>Maria Schmitt Institute, Florian&#x00f3;polis, Santa Catarina, Brazil</aff>
            </contrib-group>
            <author-notes>
                <corresp id="c1">
                    <label>a</label>
                    <email xlink:href="mailto:ednaenfa25@gmail.com">ednaenfa25@gmail.com</email>
                </corresp>
                <fn fn-type="conflict">
                    <p>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>18</day>
                <month>12</month>
                <year>2023</year>
            </pub-date>
            <pub-date pub-type="collection">
                <year>2023</year>
            </pub-date>
            <volume>12</volume>
            <elocation-id>627</elocation-id>
            <history>
                <date date-type="accepted">
                    <day>12</day>
                    <month>12</month>
                    <year>2023</year>
                </date>
            </history>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2023 Jesus ERd et al.</copyright-statement>
                <copyright-year>2023</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <self-uri content-type="pdf" xlink:href="https://f1000research.com/articles/12-627/pdf"/>
            <abstract>
                <sec>
                    <title>Background</title>
                    <p>This database aims to present the sociodemographic and clinical profile of a cohort of 799 patients hospitalized with coronavirus disease 2019 (COVID-19) in two hospitals in southern Brazil.</p>
                </sec>
                <sec>
                    <title>Methods</title>
                    <p>Data were collected, retrospectively, from November 2020 to January 2021, from the medical records of all hospital admissions that occurred from 1 April 2020 to 31 December 2020. The analysis of these data can contribute to the definition of the clinical and sociodemographic profile of patients with COVID-19.</p>
                </sec>
                <sec>
                    <title>Data description</title>
                    <p>This dataset covers 799 patients hospitalized for COVID-19, characterized by the following sociodemographic variables: sex, age group, race, marital status and paid work. The sex variable was collected as sex assigned at birth from medical records data. Clinical variables included: admission to clinical ward, hospitalization in the Intensive Care Unit, COVID-19 diagnosis, number of times hospitalized due to COVID, hospitalization time in days and risk classification protocol. Other clinical variables include: pulmonary impairment; patients ventilation pattern; high-flow oxygen mask; pulmonary thromboembolism; cardiovascular disease; pulmonary sepsis; influenza exam results. Other health problems: diabetes, systemic arterial hypertension, chronic obstructive pulmonary disease, obesity, tabaco smoking, asthma, chronic kidney disease, overweight, vascular accident, sedentary lifestyle, HIV/AIDS, cancer, Alzheimer's disease, Parkinson's disease.</p>
                </sec>
                <sec>
                    <title>Conclusions</title>
                    <p>The analysis of these data can contribute to the definition of the clinical and sociodemographic profile of patients with COVID-19. Thus, a great social impact is demonstrated when databases are published. Open data accelerates the research process, facilitates reuse and enriches datasets, in addition to optimizing the application of public resources, that is, enabling more use of the same investment.</p>
                </sec>
            </abstract>
            <kwd-group kwd-group-type="author">
                <kwd>Coronaviruse</kwd>
                <kwd>COVID-19</kwd>
                <kwd>COVID-19 pandemic</kwd>
                <kwd>COVID-19 Virus Infection</kwd>
                <kwd>Epidemic by New Coronavirus 2019</kwd>
            </kwd-group>
            <funding-group>
                <award-group id="fund-1">
                    <funding-source>The project is funded by the Foundation for Research Support of Santa Catarina (FAPESC)</funding-source>
                    <award-id>2021TR1530</award-id>
                </award-group>
                <funding-statement>The project is funded by the Foundation for Research Support of Santa Catarina (FAPESC).</funding-statement>
                <funding-statement>
                    <italic>The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</italic>
                </funding-statement>
            </funding-group>
        </article-meta>
        <notes>
            <sec sec-type="version-changes">
                <label>Revised</label>
                <title>Amendments from Version 1</title>
                <p>Changes were made according to the reviewer's suggestion: risk classification protocol (green, yellow, red and not informed), the classification was defined in the protocol according to Manchester Triage System.
                    <sup>&#x00a0;</sup>Other clinical variables included: pulmonary impairment according to medical diagnosis based on lung tomography evaluation: &lt;50%, between 50 and 75% or &gt;75%.</p>
            </sec>
        </notes>
    </front>
    <body>
        <sec id="sec1" sec-type="intro">
            <title>Introduction</title>
            <p>The coronavirus disease 2019 (COVID-19) pandemic has been considered the greatest challenge of the present time, associated with the unprecedented crisis in the health area, due to the expressive demand for hospital beds by patients with severe coronavirus conditions, which resulted in the collapse of health systems worldwide.
                <sup>
                    <xref ref-type="bibr" rid="ref1">1</xref>
                </sup>
                <sup>&#x2013;</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref3">3</xref>
                </sup> Patients affected by COVID-19 have shown clinical and sociodemographic variations, with a mortality rate around 2% in cases where there is massive alveolar damage and progressive respiratory failure.
                <sup>
                    <xref ref-type="bibr" rid="ref4">4</xref>
                </sup>
                <sup>&#x2013;</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref7">7</xref>
                </sup> Sex and gender variables also influenced COVID-19 epidemiology.
                <sup>
                    <xref ref-type="bibr" rid="ref8">8</xref>
                </sup> Its lethality varies, above all, according to age group, clinical conditions and pre-existing comorbidities, such as arterial hypertension, diabetes, previous pulmonary disease, cardiovascular disease, cerebrovascular disease, immunosuppression and cancer.
                <sup>
                    <xref ref-type="bibr" rid="ref9">9</xref>
                </sup>
                <sup>&#x2013;</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref12">12</xref>
                </sup> Although there are disparities with regard to clinical variables and comorbidities associated with increased risk of hospitalization and mortality from COVID-19, growing evidence shows that patients with pre-existing diseases, and advanced age, are especially at risk of death due to viral infection.
                <sup>
                    <xref ref-type="bibr" rid="ref13">13</xref>
                </sup>
                <sup>&#x2013;</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref16">16</xref>
                </sup> Therefore, future analyses of this database can contribute to the analysis of characteristics of hospital admissions of patients affected by COVID-19. This database contains relevant information on the sociodemographic and clinical characteristics of patients hospitalized by COVID-19. The publication of the database promotes open science, the integrity and quality of scientific production and the reuse of data.</p>
        </sec>
        <sec id="sec2" sec-type="methods">
            <title>Methods</title>
            <sec id="sec3">
                <title>Ethical approval and consent to participate</title>
                <p>This research was approved by the Research Ethics Committee of the Federal University of Santa Catarina (UFSC), (opinion No. 4.323.917/2020) Santa Catarina, Brazil. Patients provided written informed consent for data collection and publication.</p>
            </sec>
            <sec id="sec4">
                <title>Research design and method of data collection</title>
                <p>This database comes from a cohort of patients who were admitted with a diagnosis of COVID-19 in two hospitals in southern Brazil. Retrospectively, from November 2020 to January 2021, data were collected from medical records of all hospital admissions that occurred from 1 April 2020 to 31 December 2020. Data related to the sex of the patients refer to the biological characteristics at birth from the patients&#x2019; medical records. All patients aged 18 years or older were included. This dataset covers 799 hospitalized patients.</p>
                <p>Questionnaires hosted in the Survey Monkey platform were used, which contained questions about sociodemographic data, health conditions, and clinical, therapeutic, and outcome data. The variables considered for this study were: sex, age, age group, race, marital status, years of education, number of hospitalizations, hospitalization units, length of hospitalizations, risk classification, whether a COVID-19 test was taken, test used to detect COVID-19, respiratory compromise, ventilatory pattern, evolution, and previous diseases.</p>
                <p>The inclusion criteria were: hospital admissions with a medical diagnosis of COVID-19; and being 18 years old or older. Individuals under 18 years of age and those who were not hospitalized due to COVID-19 were excluded.</p>
            </sec>
            <sec id="sec5">
                <title>Data description</title>
                <p>Data were characterized by the following variables: sex, age group, race, marital status and paid work. The following clinical variables are included: admission to clinical ward, hospitalization in the Intensive Care Unit (ICU), COVID-19 diagnosis, number of times hospitalized by COVID, hospitalization time in days and risk classification protocol (green, yellow, red and not informed), the classification was defined in the protocol according to Manchester Triage System.
                    <sup>
                        <xref ref-type="bibr" rid="ref17">17</xref>
                    </sup>
                    <sup>,</sup>
                    <sup>
                        <xref ref-type="bibr" rid="ref18">18</xref>
                    </sup> Other clinical variables included: pulmonary impairment according to medical diagnosis based on lung tomography evaluation: &lt;50%, between 50 and 75% or &gt;75%; patients ventilation pattern (presented dyspnea with respiratory effort, dyspnea without effort or without dyspnea); high-flow oxygen mask; pulmonary thromboembolism (PE); cardiovascular disease; pulmonary sepsis (according to medical diagnosis of pulmonary sepsis); influenza exam results. Other health problems (if yes or no): diabetes, systemic arterial hypertension, chronic obstructive pulmonary disease (COPD), obesity, tabaco smoking, asthma, chronic kidney disease, overweight, vascular accident (Stroke), sedentary lifestyle, human immunodeficiency virus (HIV/AIDS), cancer, Alzheimer's disease, Parkinson's disease. The description of these characteristics is provided in 
                    <xref ref-type="table" rid="T1">Table 1</xref>. The analysis and reuse of sociodemographic and clinical profile data can be performed using descriptive statistics and measures of central tendency (mean and median) and variability (standard deviation and interquartile range), as well as absolute and relative distributions (n-%). The symmetry of the continuous distribution can be assessed using the Kolmogorov-Smirnov test. The predictive power of the variables can be analyzed using logistic regression. The opening of data from research projects is one of the most important elements of the research lifecycle for the success of Open Science. This is a 
                    <italic toggle="yes">sine qua non</italic> for reproducibility and scientific progress. Open Data speeds up the research process, facilitates reuse and enriches data sets, in addition to optimizing the application of public resources, in other words, enabling more use of the same investment. Opening data also allows detecting false, biased and inaccurate conclusions, as they are subject to replicability tests. Thus, great social impact is demonstrated when databases are published.
                    <sup>
                        <xref ref-type="bibr" rid="ref19">19</xref>
                    </sup>
                </p>
                <table-wrap id="T1" orientation="portrait" position="float">
                    <label>Table 1. </label>
                    <caption>
                        <title>Overview of data file.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Label</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Name of data file/data set</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">File types (file extension)</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Data repository and identifier (DOI or accession number)</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <italic toggle="yes">Data file 1</italic>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">COVID-19 Hospital Admissions database</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">COVID-19 Hospital Admissions Database.xlsx</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.6084/m9.figshare.16746073.v4">https://doi.org/10.6084/m9.figshare.16746073.v4</ext-link>
                                </td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
            </sec>
            <sec id="sec6">
                <title>Dataset validation</title>
                <p>
                    <italic toggle="yes">Limitations</italic>
                </p>
                <p>This dataset is limited to a retrospective cohort of patients from two hospitals in southern Brazil. This can be considered a limitation. The variables regarding the pulmonary condition, such as sepsis and pulmonary involvement, ended up being defined by the medical group, through a medical report of tomography and clinical medical diagnosis of pulmonary sepsis, which could be seen as a limitation in the study. However, the data are very relevant, as there are few published studies and databases available on COVID-19 in Brazil. Researchers interested in the sociodemographic and clinical profile of patients hospitalized for COVID-19 can extensively explore the variables described here.</p>
                <p>
                    <italic toggle="yes">Ethical considerations</italic>
                </p>
                <p>The present study was approved by the Research Ethics Committee of the Federal University of Santa Catarina (UFSC), (opinion No. 4.323.917/2020) Santa Catarina, Brazil. The basis and necessary information about the study objectives and method were given to all participants before the commencement of the study, and written informed consent was obtained from them. Participants consented to data publication. Participants were assured of the confidentiality of data and that only general statistics would be presented.</p>
            </sec>
        </sec>
        <sec id="sec7">
            <title>Authors&#x2019; contributions</title>
            <p>ERJ, EL and JEWB made substantial contributions to the conception and design of the work, or the acquisition, analysis or interpretation of data, and to the writing of the work or critically reviewing important intellectual content. They have given final approval to the version and have agreed to be responsible for all aspects of the work, ensuring that issues relating to the accuracy or completeness of any part of the work are properly investigated and resolved. JCRL, FMP, RSV, MAG, TCN, MCSA, MMP, MMM, CRS, WMCJ, VCCW, made substantial contributions to the acquisition of the data and the writing of the paper. They have approved the final version and agree to be responsible for all aspects of the work, ensuring that issues relating to the accuracy or completeness of any part of the work are properly investigated and resolved. All authors read and approved the final manuscript.</p>
        </sec>
    </body>
    <back>
        <sec id="sec10" sec-type="data-availability">
            <title>Data availability</title>
            <sec id="sec11">
                <title>Underlying data</title>
                <p>Figshare: Covid-19 Hospital Admissions Database.xlsx. 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.6084/m9.figshare.16746073.v4">https://doi.org/10.6084/m9.figshare.16746073.v4</ext-link>.
                    <sup>

                        <xref ref-type="bibr" rid="ref19">19</xref>
</sup>
                </p>
                <p>Data are available under the terms of the 
                    <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International license</ext-link> (CC-BY 4.0).</p>
                <p>This is an open access database distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction, provided the original work is properly cited.</p>
            </sec>
        </sec>
        <ack>
            <title>Acknowledgments</title>
            <p>The authors gratefully acknowledge the Foundation for Research Support of Santa Catarina (FAPESC).</p>
        </ack>
        <ref-list>
            <title>References</title>
            <ref id="ref1">
                <label>1</label>
                <mixed-citation publication-type="other">
                    <collab>Pan American Health Organization</collab>:
                    <article-title>Coronavirus Disease (COVID-19) pandemic.</article-title>
                    <year>2020</year>.
                    <ext-link ext-link-type="uri" xlink:href="https://www.paho.org/bra/index.php?option=com_content&amp;view=article&amp;id=6101:covid19&amp;Itemid=875">Reference Source</ext-link>
                </mixed-citation>
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            <title-group>
                <article-title>Reviewer response for version 2</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
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                        <surname>Defante Ferreto</surname>
                        <given-names>Lirane Elize</given-names>
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                    <xref ref-type="aff" rid="r231065a1">1</xref>
                    <role>Referee</role>
                </contrib>
                <aff id="r231065a1">
                    <label>1</label>Health Sciences Center, Postgraduate Program in Applied Health Sciences, Public Health Lab and Biosciences and Health Lab, Universidade Estadual do Oeste do Parana, Cascavel, State of Paran&#x00e1;, Brazil</aff>
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            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>23</day>
                <month>1</month>
                <year>2024</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2024 Defante Ferreto LE</copyright-statement>
                <copyright-year>2024</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport231065" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.130532.2"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>In response to the author's comments, a lingering uncertainty requiring clarification and refinement within the presented text persists. According to the information provided by the author, a sedentary lifestyle was defined as the absence of physical activity, and patients also reported that, in general, they do not engage in daily activities that increase the body's caloric expenditure. However, uncertainty remains regarding how this information was collected in cases of patients with moderate to severe conditions, such as those requiring oxygen or being intubated upon arrival at the hospital unit. Therefore, the proposal aims to elucidate the data collection procedures in order to ensure the reliability of the data.</p>
            <p>Are sufficient details of methods and materials provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Is the rationale for creating the dataset(s) clearly described?</p>
            <p>Yes</p>
            <p>Are the datasets clearly presented in a useable and accessible format?</p>
            <p>Yes</p>
            <p>Are the protocols appropriate and is the work technically sound?</p>
            <p>Partly</p>
            <p>Reviewer Expertise:</p>
            <p>Research area in infectious and contagious diseases with a project similar to the one presented with the collection of information from patients hospitalized with COVID-19.</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report231066">
        <front-stub>
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            <title-group>
                <article-title>Reviewer response for version 2</article-title>
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            <contrib-group>
                <contrib contrib-type="author">
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                        <surname>L&#x00f3;pez-Izquierdo</surname>
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                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0001-5092-4138</uri>
                </contrib>
                <aff id="r231066a1">
                    <label>1</label>Emergency, Hospital Universitario R&#x00ed;o Hortega, Valladolid, Valladolid, Spain</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>3</day>
                <month>1</month>
                <year>2024</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2024 L&#x00f3;pez-Izquierdo R</copyright-statement>
                <copyright-year>2024</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport231066" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.130532.2"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve</meta-value>
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            </custom-meta-group>
        </front-stub>
        <body>
            <p>The authors have made the requested corrections.</p>
            <p>Are sufficient details of methods and materials provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Is the rationale for creating the dataset(s) clearly described?</p>
            <p>Yes</p>
            <p>Are the datasets clearly presented in a useable and accessible format?</p>
            <p>Yes</p>
            <p>Are the protocols appropriate and is the work technically sound?</p>
            <p>Partly</p>
            <p>Reviewer Expertise:</p>
            <p>Research area in emergency and infectious. I participated in various studies about COVID-19 prognosis.</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.</p>
        </body>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report221267">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.143299.r221267</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>L&#x00f3;pez-Izquierdo</surname>
                        <given-names>Ra&#x00fa;l</given-names>
                    </name>
                    <xref ref-type="aff" rid="r221267a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0001-5092-4138</uri>
                </contrib>
                <aff id="r221267a1">
                    <label>1</label>Emergency, Hospital Universitario R&#x00ed;o Hortega, Valladolid, Valladolid, Spain</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>23</day>
                <month>11</month>
                <year>2023</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2023 L&#x00f3;pez-Izquierdo R</copyright-statement>
                <copyright-year>2023</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport221267" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.130532.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>This article presents an open database to advance knowledge of the COVID-19 disease. It presents relative data from the beginning of the pandemic until the end of 2020, that is, in the first phase of this. It has been shown, as the authors indicate, that the lethality of this infection is marked by the age of the patients and their comorbidity.</p>
            <p> </p>
            <p> Research design and data collection method 
                <list list-type="bullet">
                    <list-item>
                        <p>Inclusion criteria are appropriate</p>
                    </list-item>
                </list> Data description 
                <list list-type="bullet">
                    <list-item>
                        <p>The description of the variables is partially adequate. I think the age variable should be shown as a continuous and uncategorized variable.</p>
                    </list-item>
                    <list-item>
                        <p>The authors should better describe some of the qualitative variables they present, and explain the categories that make them up. Among these variables that would have to be explained would be: risk classification protocol, pulmonary impairment and pulmonary sepsis.</p>
                    </list-item>
                </list>
            </p>
            <p>Are sufficient details of methods and materials provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Is the rationale for creating the dataset(s) clearly described?</p>
            <p>Yes</p>
            <p>Are the datasets clearly presented in a useable and accessible format?</p>
            <p>Yes</p>
            <p>Are the protocols appropriate and is the work technically sound?</p>
            <p>Partly</p>
            <p>Reviewer Expertise:</p>
            <p>Research area in emergency and infectious. I participated in various studies about COVID-19 prognosis.</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
        <sub-article article-type="response" id="comment10747-221267">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Ribeiro de Jesus</surname>
                            <given-names>Edna</given-names>
                        </name>
                        <aff>Universidade Federal de santa Catarina, Brazil</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>11</day>
                    <month>12</month>
                    <year>2023</year>
                </pub-date>
            </front-stub>
            <body>
                <p>
                    <bold>Response to reviewer</bold>
                </p>
                <p> 
                    <bold>We gratefully thank the reviewer for their interest in our paper and for the invitation to revise this manuscript. Thank you very much for your carefully revision and for spending your time collaborating to improve our manuscript.</bold>
                </p>
                <p> 
                    <bold>&#x00a0;</bold>
                </p>
                <p> 
                    <bold>Below, we will elaborate on how we have responded to each comment and suggestion by the reviewer. We hope you will find that we have dealt satisfactorily with all comments and suggestions made by the reviewer.</bold>
                </p>
                <p> 
                    <bold>Yours sincerely,</bold>
                </p>
                <p> 
                    <bold>Authors</bold>
                </p>
                <p> </p>
                <p> 
                    <italic>This article presents an open database to advance knowledge of the COVID-19 disease. It presents relative data from the beginning of the pandemic until the end of 2020, that is, in the first phase of this. It has been shown, as the authors indicate, that the lethality of this infection is marked by the age of the patients and their comorbidity.</italic>
                </p>
                <p> 
                    <bold>R: Thank you for your comment.</bold>
                </p>
                <p> </p>
                <p> 
                    <italic>Research design and data collectio</italic>n method</p>
                <p> Inclusion criteria are appropriate</p>
                <p> 
                    <bold>R: Thank you for your comment.</bold>
                </p>
                <p> </p>
                <p> Data description</p>
                <p> The description of the variables is partially adequate. I think the age variable should be shown as a continuous and uncategorized variable.</p>
                <p> </p>
                <p> 
                    <bold>R:</bold> 
                    <bold>We sincerely appreciate your valuable feedback and thorough review of our work. We have taken into consideration your suggestion regarding the presentation of the age variable.</bold>
                </p>
                <p> 
                    <bold>In the specific case of the age variable, we recognize its relevance for understanding the nuances of our study. However, by disclosing specific details about the age of participants, we run the risk of compromising the identity of some subjects. From then on, this variable was kept in groups to maintain anonymity, as is available in the published database.</bold>
                </p>
                <p> 
                    <bold>&#x00a0;However, we have this variable in its continuous presentation to make it available to researchers who are interested.</bold>
                </p>
                <p> </p>
                <p> 
                    <italic>The authors should better describe some of the qualitative variables they present, and explain the categories that make them up. Among these variables that would have to be explained would be: risk classification protocol, pulmonary impairment and pulmonary sepsis.</italic>
                </p>
                <p> </p>
                <p> 
                    <bold>We are committed to addressing your recommendations and thank you for pointing out ways to improve the description of the variables</bold>
                </p>
                <p> </p>
                <p> 
                    <bold>Risk classification protocol</bold>
                </p>
                <p> 
                    <bold>R: The risk classification protocol was defined according to The Manchester Triage System (MTS)
                        <sup>1-3</sup>.&#x00a0;&#x00a0; The risk classification protocol is an essential qualitative variable that describes the system used to assess and categorize the severity of patients' clinical condition. This protocol may include criteria such as heart rate, blood pressure, oxygen saturation, among others. Each category within the protocol represents different levels of severity, aiding in identifying patients who require immediate attention, intensive monitoring, or regular care. We will detail the specific categories within the protocol, highlighting the criteria used for risk classification
                        <sup>1-3</sup>.</bold>
                </p>
                <p> </p>
                <p> 
                    <bold>Reference: </bold>
                </p>
                <p> 
                    <bold>
                        <sup>1</sup>
                    </bold>
                    <bold> </bold>Mackway-Jones K, Marsden J, Windle J. Sistema Manchester de Classifica&#x00e7;&#x00e3;o de Risco. 2nd ed. Belo Horizonte: Folium; 2017.</p>
                <p> 
                    <sup>2</sup>Farrohknia N, Castr&#x00e9;n M, Ehrenberg A, Lind L, Oredsson S, Jonsson H, et al. Emergency Department Triage Scales and their components: a systematic review of the scientific evidence. Scand J Trauma Resusc Emerg Med [Internet]. 2011 [cited 2023 Dec 8]; 19:42. Available from:&#x00a0;
                    <ext-link ext-link-type="uri" xlink:href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150303/">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150303/</ext-link>
                </p>
                <p> </p>
                <p> 
                    <bold>Pulmonary impairment</bold>
                    <bold> </bold>
                </p>
                <p> 
                    <bold>R: The Pulmonary impairment variable was collected through the medical report of the lung tomography considering the following impairment values: less than 50%, between 50% and 75% and greater than 75%. </bold>
                </p>
                <p> </p>
                <p> 
                    <bold>Pulmonary sepsis</bold>
                </p>
                <p> 
                    <bold>R: The pulmonary sepsis variable was collected from electronic medical records based on medical diagnosis.</bold>
                </p>
            </body>
        </sub-article>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report178045">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.143299.r178045</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Defante Ferreto</surname>
                        <given-names>Lirane Elize</given-names>
                    </name>
                    <xref ref-type="aff" rid="r178045a1">1</xref>
                    <role>Referee</role>
                </contrib>
                <aff id="r178045a1">
                    <label>1</label>Health Sciences Center, Postgraduate Program in Applied Health Sciences, Public Health Lab and Biosciences and Health Lab, Universidade Estadual do Oeste do Parana, Cascavel, State of Paran&#x00e1;, Brazil</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>14</day>
                <month>6</month>
                <year>2023</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2023 Defante Ferreto LE</copyright-statement>
                <copyright-year>2023</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport178045" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.130532.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>The information available can be accessed by researchers who are interested in better understanding health policies, planning health actions, and estimating costs and demands in emergency situations. Database studies of this nature are important as they contribute to improving the effectiveness of health promotion and prevention actions. The results of data analysis provide information to managers who can assess the situation and identify critical points and propose strategies in situations that require immediate solutions.</p>
            <p> </p>
            <p> Review the inclusion and exclusion criteria. The author informs, &#x201c;The inclusion criteria were: hospital admissions with a medical diagnosis of COVID-19; and be 18 years or older. Individuals under 18 years of age and those who were not hospitalized due to COVID-19 were excluded&#x201d;, so if being 18 years of age or older is an inclusion criterion and hospital admissions with a medical diagnosis of COVID-19, the exclusion criteria must be those within this population who were included, not being 18 years old and being hospitalized for COVID-19 was already a characteristic or circumstance that prevented the inclusion of the subject in the study.</p>
            <p> </p>
            <p> In the variables, the inclusion criterion is having a diagnosis of COVID-19 and being hospitalized, the diagnostic variable for COVID-19 is not justified since everyone in the study has this outcome. Inform how the risk classification (green, yellow, red and not informed) was defined in the protocol in the study patients. Is it relevant that the author informs the distinction between obesity and overweight, would it not be possible to present this information in a single variable? It is not clear in the text how the authors defined a sedentary lifestyle. It is suggested that age in the bank be presented as a continuous variable, which allows the application of numerous statistical methods with better power for inference and modeling. As the authors inform that they collected data regarding income, the information in the database would be interesting.</p>
            <p> </p>
            <p> As argued by the authors, &#x201c;open data streamline the research process, facilitate reuse and enrich datasets, in addition to optimizing the application of public resources, that is, enabling greater use of the same investment&#x201d;, it would be recommended that the authors inform the geographical location of the two hospitals in southern Brazil, as well as better describing the population from which the sample originated.</p>
            <p> </p>
            <p> I understand that this information described by the author &#x201c;Researchers interested in the sociodemographic and clinical profile of patients hospitalized for COVID-19 can widely explore the variables described here&#x201d;, is not a limitation.</p>
            <p>Are sufficient details of methods and materials provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Is the rationale for creating the dataset(s) clearly described?</p>
            <p>Yes</p>
            <p>Are the datasets clearly presented in a useable and accessible format?</p>
            <p>Yes</p>
            <p>Are the protocols appropriate and is the work technically sound?</p>
            <p>Partly</p>
            <p>Reviewer Expertise:</p>
            <p>Research area in infectious and contagious diseases with a project similar to the one presented with the collection of information from patients hospitalized with COVID-19.</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
        <sub-article article-type="response" id="comment9868-178045">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Ribeiro de Jesus</surname>
                            <given-names>Edna</given-names>
                        </name>
                        <aff>Universidade Federal de santa Catarina, Brazil</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>5</day>
                    <month>7</month>
                    <year>2023</year>
                </pub-date>
            </front-stub>
            <body>
                <p>
                    <bold>Response to reviewer</bold>
                </p>
                <p>
                    <bold> </bold>
                </p>
                <p>
                    <bold> We gratefully thank the reviewer for their interest in our paper and for the invitation to revise this manuscript.&#x00a0;Thank you very much for your carefully revision and for spending your time collaborating to improve our manuscript.</bold>
                </p>
                <p>
                    <bold> &#x00a0;</bold>
                </p>
                <p>
                    <bold> Below, we will elaborate on how we have responded to each comment and suggestion by the reviewer. We hope you will find that we have dealt satisfactorily with all comments and suggestions made by the reviewer.</bold>
                </p>
                <p>
                    <bold> Yours sincerely,</bold>
                </p>
                <p>
                    <bold> Authors</bold>
                </p>
                <p> </p>
                <p> The information available can be accessed by researchers who are interested in better understanding health policies, planning health actions, and estimating costs and demands in emergency situations. Database studies of this nature are important as they contribute to improving the effectiveness of health promotion and prevention actions. The results of data analysis provide information to managers who can assess the situation and identify critical points and propose strategies in situations that require immediate solutions.</p>
                <p> </p>
                <p> 
                    <bold>R: Thank you for your comment.</bold>
                </p>
                <p> </p>
                <p> Review the inclusion and exclusion criteria. The author informs, &#x201c;The inclusion criteria were: hospital admissions with a medical diagnosis of COVID-19; and be 18 years or older. Individuals under 18 years of age and those who were not hospitalized due to COVID-19 were excluded&#x201d;, so if being 18 years of age or older is an inclusion criterion and hospital admissions with a medical diagnosis of COVID-19, the exclusion criteria must be those within this population who were included, not being 18 years old and being hospitalized for COVID-19 was already a characteristic or circumstance that prevented the inclusion of the subject in the study.</p>
                <p> </p>
                <p> 
                    <bold>R: Thank you for your comment. Yes, there is no exclusion criteria to inform for this study. We have collected data from medical records of all hospital admissions due to COVID-19 of patients 18 years or older, that occurred from 1 April 2020 to 31 December 2020.</bold>
                </p>
                <p> </p>
                <p> In the variables, the inclusion criterion is having a diagnosis of COVID-19 and being hospitalized, the diagnostic variable for COVID-19 is not justified since everyone in the study has this outcome. Inform how the risk classification (green, yellow, red and not informed) was defined in the protocol in the study patients. Is it relevant that the author informs the distinction between obesity and overweight, would it not be possible to present this information in a single variable? It is not clear in the text how the authors defined a sedentary lifestyle. It is suggested that age in the bank be presented as a continuous variable, which allows the application of numerous statistical methods with better power for inference and modeling. As the authors inform that they collected data regarding income, the information in the database would be interesting.</p>
                <p> </p>
                <p> 
                    <bold>R: The risk classification (green, yellow, red and not informed) was defined in the protocol according to The Manchester Triage System (MTS). It enables nurses to assign a clinical priority to patients, based on presenting signs and symptoms, without making any assumption about the underlying diagnosis.</bold>
                </p>
                <p>
                    <bold> Sedentary lifestyle was defined as, in addition to not exercising, patient mentioned that usually in their life there is no basic day-to-day activities that increase the body's caloric expenditure.</bold>
                </p>
                <p>
                    <bold> </bold>
                </p>
                <p>
                    <bold> Data related to obesity, overweight and sedentary lifestyle were retrieved from hospitals multidisciplinary team notes registered in medical records, which rely on individual professional evaluation of patients during usual care. The accuracy of this data can not be verified. Data related to patients age was categorized to avoid patient identification. We are open to present this data as well data regarding income, under demand, to editors/researchers.</bold>
                </p>
                <p> </p>
                <p> As argued by the authors, &#x201c;open data streamline the research process, facilitate reuse and enrich datasets, in addition to optimizing the application of public resources, that is, enabling greater use of the same investment&#x201d;, it would be recommended that the authors inform the geographical location of the two hospitals in southern Brazil, as well as better describing the population from which the sample originated.</p>
                <p> </p>
                <p> 
                    <bold>R: Our study was carried out in two public hospitals in the state of Santa Catarina, Brazil. One from Lages city and on from the capital, Florian&#x00f3;polis. It is a cohort of all patients who were hospitalized with a diagnosis of COVID-19.</bold>
                </p>
                <p> </p>
                <p> I understand that this information described by the author &#x201c;Researchers interested in the sociodemographic and clinical profile of patients hospitalized for COVID-19 can widely explore the variables described here&#x201d;, is not a limitation.</p>
                <p> </p>
                <p> 
                    <bold>R: Thank you for your comment. We agree that this is not a limitation. A limitation we can now identify is that data about obesity, overweight and sedentary lifestyle were retrieved from hospitals multidisciplinary team notes registered in medical records, which rely on individual professional evaluation of patients during usual care. The accuracy of this data can not be verified.</bold>
                </p>
            </body>
        </sub-article>
    </sub-article>
</article>
