<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN" "http://jats.nlm.nih.gov/publishing/1.2/JATS-journalpublishing1.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="research-article" dtd-version="1.2" xml:lang="en">
    <front>
        <journal-meta>
            <journal-id journal-id-type="pmc">F1000Research</journal-id>
            <journal-title-group>
                <journal-title>F1000Research</journal-title>
            </journal-title-group>
            <issn pub-type="epub">2046-1402</issn>
            <publisher>
                <publisher-name>F1000 Research Limited</publisher-name>
                <publisher-loc>London, UK</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="doi">10.12688/f1000research.138742.2</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Research Article</subject>
                </subj-group>
                <subj-group>
                    <subject>Articles</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Esthetic preferences of orthodontists, general dentists, and laypersons for Indian facial profiles: A cross-sectional study</article-title>
                <fn-group content-type="pub-status">
                    <fn>
                        <p>[version 2; peer review: 3 approved]</p>
                    </fn>
                </fn-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author" corresp="no" equal-contrib="yes">
                    <name>
                        <surname>Reddy</surname>
                        <given-names>Harshini</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Resources</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no" equal-contrib="yes">
                    <name>
                        <surname>Singla</surname>
                        <given-names>Ritesh</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Project Administration</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-1215-5988</uri>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="yes">
                    <name>
                        <surname>Singla</surname>
                        <given-names>Nishu</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Resources</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-9007-8092</uri>
                    <xref ref-type="corresp" rid="c1">a</xref>
                    <xref ref-type="aff" rid="a2">2</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Natarajan</surname>
                        <given-names>Madhumitha</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Resources</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Singhal</surname>
                        <given-names>Deepak Kumar</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Resources</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="aff" rid="a2">2</xref>
                </contrib>
                <aff id="a1">
                    <label>1</label>Department of Orthodontics &amp; Dentofacial Orthopaedics, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India</aff>
                <aff id="a2">
                    <label>2</label>Department of Public Health Dentistry, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India</aff>
            </contrib-group>
            <author-notes>
                <corresp id="c1">
                    <label>a</label>
                    <email xlink:href="mailto:nishu.singla@manipal.edu">nishu.singla@manipal.edu</email>
                </corresp>
                <fn fn-type="conflict">
                    <p>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>30</day>
                <month>9</month>
                <year>2024</year>
            </pub-date>
            <pub-date pub-type="collection">
                <year>2023</year>
            </pub-date>
            <volume>12</volume>
            <elocation-id>953</elocation-id>
            <history>
                <date date-type="accepted">
                    <day>25</day>
                    <month>9</month>
                    <year>2024</year>
                </date>
            </history>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2024 Reddy H et al.</copyright-statement>
                <copyright-year>2024</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <self-uri content-type="pdf" xlink:href="https://f1000research.com/articles/12-953/pdf"/>
            <abstract>
                <p>
                    <bold>Background:</bold> Disparity in the esthetic perceptions between a patient and clinician could result in patient dissatisfaction with orthodontic treatment outcomes. The aim of this study was to compare the perceptions of a group of orthodontists, general dentists, and laypersons about the attractiveness of Indian facial profiles.</p>
                <p>
                    <bold>Methods:</bold> In this study, a male and a female participants&#x2019; photographs and lateral cephalograms were digitally manipulated by inserting them into Dolphin software; we considered four soft tissue parameters at a nasolabial angle, upper lip E-line, lower lip E-line, and pg-pg&#x2019;, so that 20 profiles were created for each model. A visual analog scale (VAS) along with a question about surgical correction opinion was given to 18 orthodontists, 18 general dentists, and 18 laypersons to score (1-5) from least to most attractive. Spearman&#x2019;s rank correlation was computed to assess correlation, as well as ANOVA, followed by 
                    <italic toggle="yes">post hoc</italic> Tukey analysis to compare the mean scores, and Chi-square test to determine the opinion about surgical treatment.</p>
                <p>
                    <bold>Results:</bold> There was an overall weak and negative correlation between the three groups, indicating that orthodontists attributed lower pleasantness scores to almost all the altered female and male facial profiles. Additionally, statistically significantly lower mean scores were attributed by orthodontists to many females and few male facial profiles. More orthodontists identified the need for surgical correction for a few severely distorted profiles but there was a statistically non-significant difference among the groups for most of the profiles.</p>
                <p>
                    <bold>Conclusions:</bold> It was concluded that participants in the three groups had diverse concepts of facial attractiveness in all the parameters considered. Compared to general dentists and laypersons, orthodontists were much more precise, firmer, and meticulous in identifying a favorable or good-looking profile.</p>
            </abstract>
            <kwd-group kwd-group-type="author">
                <kwd>Indian facial profiles</kwd>
                <kwd>esthetic</kwd>
                <kwd>perceptions</kwd>
                <kwd>orthodontists</kwd>
                <kwd>general dentists</kwd>
                <kwd>layperson</kwd>
            </kwd-group>
            <funding-group>
                <funding-statement>The author(s) declared that no grants were involved in supporting this work.</funding-statement>
            </funding-group>
        </article-meta>
        <notes>
            <sec sec-type="version-changes">
                <label>Revised</label>
                <title>Amendments from Version 1</title>
                <p>Title:&#x00a0;no change Abstract: no change Author list: no change Figures: no change Table 1 to Table 3: An&#x00a0;asterisk (*) has been added behind values that are less than 0.05. Introduction: To enhance clarity, the text has been corrected for spelling, grammar, and punctuation.&#x00a0; Methods: The grammar has been corrected, and sentences have been rephrased as per the reviewer&#x2019;s suggestions. Statistical data analysis: The term &#x201c;orthodontic education&#x201d; has been corrected in the second sentence, and the text has been rephrased according to the reviewer&#x2019;s recommendations. Discussion: Limitations of the study and recommendations have been added to the final paragraph. Conclusions: The conclusion has been revised to align more closely with the study's objectives. References: Reference number 20 from the previous version has been removed for improved accuracy.</p>
            </sec>
        </notes>
    </front>
    <body>
        <sec id="sec1" sec-type="intro">
            <title>Introduction</title>
            <p>Facial aesthetics are associated with how others perceive an individual.
                <sup>
                    <xref ref-type="bibr" rid="ref1">1</xref>
                </sup> The perception of an individual as being beautiful greatly impacts how they represent themselves to others, and therefore esthetics are not absolute, but highly subjective and variable.
                <sup>
                    <xref ref-type="bibr" rid="ref2">2</xref>
                </sup> Beauty is said to be &#x201c;in the eyes of the beholder&#x201d;.
                <sup>
                    <xref ref-type="bibr" rid="ref3">3</xref>
                </sup> Each person has a different intellectual wisdom about beauty and its perception varies accordingly. Most of it is influenced by principles of one&#x2019;s self-perception. The perception of one&#x2019;s disfigurement, flaws, or imperfections may be beautiful to another. Women&#x2019;s feet in China were bound to make them small which was perceived more attractive.
                <sup>
                    <xref ref-type="bibr" rid="ref4">4</xref>
                </sup> Midline diastema was considered aesthetic among Arabs.
                <sup>
                    <xref ref-type="bibr" rid="ref5">5</xref>
                </sup>
            </p>
            <p>Facial esthetics have always been an integral part of the standards and practice of orthodontics. Even though standard occlusion remains a chief functional goal, achieving proper esthetic outcomes remains essential for the satisfaction of the patients. Individuals with an ideal dentofacial appearance are considered more good-looking socially than those with an unaesthetic dental appearance and often have low self-confidence.
                <sup>
                    <xref ref-type="bibr" rid="ref6">6</xref>
                </sup> Holdaway suggested that identifying soft tissue traits that contribute to or reduce physical attractiveness stereotypes deeply rooted in society can enhance treatment objectives.
                <sup>
                    <xref ref-type="bibr" rid="ref7">7</xref>
                </sup> Orthodontists usually judge the characteristics of facial esthetics based on smile assessments of the patient, profile, and full face. Over the years, clinical perceptions of facial esthetics have progressively shifted to using quantifiable soft-tissue diagnostic valuations. Other orthodontic treatment methods to gain esthetic considerations &#x2013; camouflage versus correction of jaw relationships, expansion versus extraction &#x2013; have become important.
                <sup>
                    <xref ref-type="bibr" rid="ref7">7</xref>
                </sup>
            </p>
            <p>The treatment should be made to achieve a harmonious facial profile with an esthetically attractive smile and functional dental occlusion. When facial attractiveness and occlusion correction are combined, treatment planning becomes difficult. Achieving an ideal occlusion does not essentially mean that decent facial balance is achieved. To achieve accurate soft tissue effect to hard tissue changes, an orthodontist should concentrate on the growth and development of soft tissue traits. They should be aware of soft tissue changes produced by orthopedic or orthodontic treatment procedures. Hence, an orthodontist should conduct a thorough facial hard tissue and soft tissue examination so that orthodontic treatment can favorably affect the facial features.
                <sup>
                    <xref ref-type="bibr" rid="ref8">8</xref>
                </sup>
            </p>
            <p>In pursuing the ideal treatment goal, aesthetics has become crucial. Therefore, it is important to consider both the aesthetic perspectives of patients and clinicians regarding facial attractiveness. The difference in perception between the clinician and patient could result in patient dissatisfaction with treatment outcomes, as the perception of esthetics may vary between an orthodontist and a layperson. Thus, this study aimed to compare the perceptions of orthodontists, general dentists, and laypersons about the attractiveness of Indian facial profiles. In addition, it was also determined whether surgical treatment was needed for the profiles.</p>
        </sec>
        <sec id="sec2" sec-type="methods">
            <title>Methods</title>
            <p>A cross-sectional study was conducted considering three groups of study participants: orthodontists, general dentists, and laypersons (who were well-educated and not from a medical background) between the ages of 18 to 50 years. The total sample size was 54 with 18 subjects in each group. Ethical clearance was obtained from the Institutional Ethical Committee of Kasturba Medical College and Kasturba Hospital (IEC approval number 790/2018) for the conduct of the study. The study participants were informed about the study through a participant information sheet following which written informed consent was obtained. A visual analog scale (VAS) and a question about surgical correction opinion were given to 18 orthodontists, 18 general dentists, and 18 laypersons to score (1-5) from least to most attractive. The time taken to answer the questionnaire was approximately 10 min.</p>
            <p>The photographs and lateral cephalograms of a 22-year-old male and a 21-year-old female were taken as study models. The standards for choosing these models comprised a well-balanced face with normal eyes, nose, and lips; class I skeletal and dental relationship; well-aligned arches; Z angle 71&#x00b0; - 89&#x00b0;. The exclusion criteria for selecting study models were class II and class III malocclusions, congenital deformities, and facial anomalies. Four soft tissue parameters were considered: nasolabial angle, upper lip E-line, lower lip E-line, and pg-pg&#x2019; (hard tissue pogonion to soft tissue pogonion). Most of the measurements of the role models were within the normal ranges.
                <sup>
                    <xref ref-type="bibr" rid="ref9">9</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref10">10</xref>
                </sup>
            </p>
            <p>Lateral cephalograms and standard high-resolution color profile photographs were taken with a white background and good brightness. Tracing the lateral cephalograms was done using Dolphin software (Dolphin Imaging 11.95 Premium Software). Lateral cephalograms were linked to their respective profile images by inserting them in the software, and nasolabial angles, E-Lines, and pg-pg&#x2019; were defined in the original pictures (
                <xref ref-type="fig" rid="f1">Figure 1</xref>). A total of 12 anatomic landmarks (eight soft tissue, four hard tissue) were recognized. The hard tissue landmarks were porion (po), sella (s), orbitale (or), and pogonion (pg). The soft tissue landmarks were pronasale (Pn), subnasale (Sn), superior labial sulcus (SLS), labrale superius (Ls), labrale inferius (Li), inferior labial sulcus (ILS), and soft tissue pogonion (pg&#x2019;) and soft tissue menton (Mn&#x2019;).</p>
            <fig fig-type="figure" id="f1" orientation="portrait" position="float">
                <label>Figure 1. </label>
                <caption>
                    <title>Lateral cephalograms were linked to their respective profile images by inserting them in the software.</title>
                </caption>
                <graphic id="gr1" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/172422/5441392f-ff1f-4595-bd29-18d0bfafc874_figure1.gif"/>
            </fig>
            <p>The pictures were digitally manipulated using the software by altering the lower component (labial part) of the nasolabial angle by 2&#x00b0; increments (increase and decrease); thus, a set of five profiles (one basic profile, two profiles with increase of nasolabial angle, two profiles with decrease of nasolabial angle) were created for each subject. The images were digitally manipulated for lower lip to E-Line and upper lip to E-Line by increasing 1 mm for two profiles and decreasing 1 mm for two profiles, and the last profile remains as the basic profile.</p>
            <p>The images were also digitally manipulated for pg-pg&#x2019; by increasing 2 mm for two profiles and by decreasing 2 mm for two profiles and the last profile remains as the basic profile. Thus, a total of 20 facial profiles were created for each model (
                <xref ref-type="fig" rid="f2">Figures 2</xref> and 
                <xref ref-type="fig" rid="f3">3</xref>): five profiles for nasolabial angle; five profiles for the upper lip E-line, five profiles for lower lip E-line; and five profiles for pg-pg&#x2019;.</p>
            <fig fig-type="figure" id="f2" orientation="portrait" position="float">
                <label>Figure 2. </label>
                <caption>
                    <title>A set of 20 constructed profile images of male by altering nasolabial angle in first row, Upper lip to E-line in second row, Lower lip to E-line in third row and Hard tissue pogonion to soft tissue pogonion in fourth row.</title>
                </caption>
                <graphic id="gr2" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/172422/5441392f-ff1f-4595-bd29-18d0bfafc874_figure2.gif"/>
            </fig>
            <fig fig-type="figure" id="f3" orientation="portrait" position="float">
                <label>Figure 3. </label>
                <caption>
                    <title>A set of 20 constructed profile images of female by altering nasolabial angle in first row, Upper lip to E-line in second row, Lower lip to E-line in third row and Hard tissue pogonion to soft tissue pogonion in fourth row.</title>
                </caption>
                <graphic id="gr3" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/172422/5441392f-ff1f-4595-bd29-18d0bfafc874_figure3.gif"/>
            </fig>
            <p>Once the profiles were reconstructed, the margins of the photos were blended out with 
                <ext-link ext-link-type="uri" xlink:href="https://www.paintshoppro.com/en/?utm_source=google&amp;utm_medium=cpc&amp;utm_campaign=psp-dd-all-adwordsppc&amp;utm_content=137310399048&amp;utm_term=paint%20shop%20pro%207&amp;utm_id=15744270911&amp;gad=1&amp;gclid=EAIaIQobChMI45iAl96wgAMVh0krCh2h3AW7EAAYASAAEgLXu_D_BwE">Paint Shop Pro</ext-link> (version 7.0) to preserve the natural appearance of the pictures. Finally, the printed copies of the pictures were taken and randomly arranged in an album with no distinct order for both female and male subjects. As consented, no masking of the face was done during the study process as it involves the assessment of facial attractiveness. The study participants were assigned to score (1-5) for each image through a Visual Analogue Scale (VAS) from least to most attractive. The participants were also asked a yes/no question to answer whether they thought the profile required any surgery to improve their facial appearance.</p>
            <sec id="sec3">
                <title>Statistical data analysis</title>
                <p>Data was entered into Microsoft Excel and evaluated using statistical software SPSS version 20. Spearman&#x2019;s rank correlation was computed to assess correlation and ANOVA, followed by 
                    <italic toggle="yes">post hoc</italic> Tukey analysis to compare the mean scores and the Chi-square test to determine the opinion about surgical treatment. The groups were ranked for Spearman&#x2019;s rank correlation based on their increasing levels of orthodontic knowledge, such as laypersons followed by general dentists and orthodontists. The Spearman&#x2019;s rank correlation coefficient (
                    <italic toggle="yes">R
                        <sub>s</sub>
                    </italic>) value lies between 1.0 and -1.0 (a perfect positive to negative correlation). The strength of a correlation depends on the value of the coefficient. A 
                    <italic toggle="yes">R
                        <sub>s</sub>
                    </italic> between 0.00 - 0.19 implies a very weak, 0.20 - 0.39 a weak, 0.40 - 0.69 a moderate, 0.70-0.89 a strong, and 0.90-1.00 a very strong correlation. Also, a R
                    <sub>s</sub> of 0 indicates no association between ranks. The 5% probability level (p &#x2264; 0.05) implied a statistically significant difference.</p>
            </sec>
        </sec>
        <sec id="sec4" sec-type="results">
            <title>Results</title>
            <p>According to the results of the Spearman&#x2019;s rank correlation test, there was an overall weak, negative correlation between the three groups for the VAS scores for most of the female and male profiles. A negative correlation indicates that the orthodontist&#x2019;s group of the highest rank gave the lowest pleasantness scores to almost all the altered female and male facial profiles on a VAS of 1-5 compared to other groups. A statistically significant but weak negative correlation was seen between the three study groups for female profiles with Nasolabial angle (+4&#x00b0;), Nasolabial angle (-4&#x00b0;), Upper lip to E-line (+2 mm), Upper lip to E- line (-1 mm), Lower lip to E-line (normal), Lower lip to E-line (-2 mm), pg-pg&#x2019; (-2 mm) and pg- pg&#x2019; (-4 mm); a moderate negative correlation for female profiles with Upper lip to E-line (-2 mm) and Lower lip to E-line (-1 mm). There was no correlation between the three groups for the profile Upper lip to E-line (normal) and a positive but very weak correlation for profiles with Nasolabial angle (normal) and Nasolabial angle (-2&#x00b0;). In contrast, the remaining female profiles showed statistically non-significant weak negative correlation as shown in 
                <xref ref-type="table" rid="T1">Table 1</xref>. For male profiles, it was found that there was a statistically significant negative weak correlation between the three study groups for profiles with Nasolabial angle (+2&#x00b0;) and Nasolabial angle (+4&#x00b0;). In contrast, all remaining male profiles showed a statistically non-significant and very weak negative correlation.</p>
            <table-wrap id="T1" orientation="portrait" position="float">
                <label>Table 1. </label>
                <caption>
                    <title>Results of Spearman&#x2019;s Rank Correlation between three study groups.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1" valign="top"/>
                            <th align="left" colspan="1" rowspan="1" valign="top">Spearman&#x2019;s Correlation for female facial profiles</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">P value</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Spearman&#x2019;s Correlation for male facial profiles</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">P value</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Nasolabial angle (+2&#x00b0;)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.242</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.08</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.305</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>0.03</bold>
                                <xref ref-type="table-fn" rid="tfn1">*</xref>
                            </td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Nasolabial angle (+4&#x00b0;)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.284</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>0.04</bold>
                                <xref ref-type="table-fn" rid="tfn1">*</xref>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.329</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>0.02</bold>
                                <xref ref-type="table-fn" rid="tfn1">*</xref>
                            </td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Nasolabial angle (normal)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.09</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.52</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.017</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.903</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Nasolabial angle (-2&#x00b0;)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.05</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.72</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.080</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.566</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Nasolabial angle (-4&#x00b0;)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.332</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>0.02</bold>
                                <xref ref-type="table-fn" rid="tfn1">*</xref>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.234</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.089</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Upper lip to E-line (+1 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.235</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.09</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.264</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.073</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Upper lip to E-line (+2 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.283</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>0.04</bold>
                                <xref ref-type="table-fn" rid="tfn1">*</xref>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.229</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.096</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Upper lip to E-line (normal)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.0</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.062</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.656</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Upper lip to E-line (-1 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.294</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>0.03</bold>
                                <xref ref-type="table-fn" rid="tfn1">*</xref>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.146</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.293</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Upper lip to E-line (-2 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.412</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>0.002</bold>
                                <xref ref-type="table-fn" rid="tfn1">*</xref>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.230</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.094</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Lower lip to E-line (+1 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.248</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.07</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.140</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.314</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Lower lip to E-line (+2 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.193</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.16</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.127</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.361</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Lower lip to E-line (normal)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.267</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>0.05</bold>
                                <xref ref-type="table-fn" rid="tfn1">*</xref>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.0 I</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.944</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Lower lip to E-line (-1 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.453</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>0.001</bold>
                                <xref ref-type="table-fn" rid="tfn1">*</xref>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.238</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.084</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Lower lip to E-line (-2 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.374</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>0.005</bold>
                                <xref ref-type="table-fn" rid="tfn1">*</xref>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.262</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.056</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">pg-pg&#x2019; (+2 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.149</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.283</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.154</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.266</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">pg-pg&#x2019; (+4 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.199</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.149</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.096</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.488</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">pg-pg&#x2019; (normal)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.073</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.598</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.078</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.576</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">pg-pg&#x2019; (-2 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.301</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>0.03</bold>
                                <xref ref-type="table-fn" rid="tfn1">*</xref>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.147</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.289</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">pg-pg&#x2019; (-4 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.313</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>0.02</bold>
                                <xref ref-type="table-fn" rid="tfn1">*</xref>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.199</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.148</td>
                        </tr>
                    </tbody>
                </table>
                <table-wrap-foot>
                    <fn-group content-type="footnotes">
                        <fn id="tfn1">
                            <label>*</label>
                            <p>P value &#x2264; 0.05 was considered a statistically significant difference.</p>
                        </fn>
                    </fn-group>
                </table-wrap-foot>
            </table-wrap>
            <p>The results of ANOVA presented in 
                <xref ref-type="table" rid="T2">Table 2</xref> show that the orthodontist group attributed lower mean scores to almost all the altered female and male facial profiles. However, statistically significant differences in mean scores were noted for female profiles with Nasolabial angle (+4&#x00b0;), Nasolabial angle (-4&#x00b0;), Upper lip to E-line (-1 mm), Upper lip to E- line (-2 mm), Lower lip to E-line (normal), Lower lip to E-line (-1 mm), Lower lip to E-line (-2 mm), pg-pg&#x2019; (+4 mm), pg-pg&#x2019; (normal) and pg-pg&#x2019; (-4 mm). 
                <italic toggle="yes">Post hoc</italic> analysis showed that for female profiles with Lower lip to E-line (normal) and pg-pg&#x2019; (normal), orthodontists significantly differed from general dentists; for profiles with Nasolabial angle (+4&#x00b0;), Nasolabial angle (-4&#x00b0;), Upper lip to E-line (-1 mm), Upper lip to E-line (-2 mm), Lower lip to E-line (-1 mm), Lower lip to E-line (-2 mm) and pg-pg&#x2019; (-4 mm), orthodontists significantly differed from laypersons. In contrast, for male profiles, only profiles with Nasolabial angle (+2&#x00b0;), Nasolabial angle (+4&#x00b0;), and pg-pg&#x2019; (+4 mm) were statistically different in the responses between the three groups, and the 
                <italic toggle="yes">post hoc</italic> analysis showed that for profiles with Nasolabial angle (+2&#x00b0;) and Nasolabial angle (+4&#x00b0;), orthodontists significantly differed from laypersons. Meanwhile, all remaining profiles of the male model showed statistically non-significant differences between the three groups (
                <xref ref-type="table" rid="T2">Table 2</xref>).</p>
            <table-wrap id="T2" orientation="portrait" position="float">
                <label>Table 2. </label>
                <caption>
                    <title>Results of ANOVA followed by post hoc Tukey analysis between three study groups.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1" valign="top"/>
                            <th align="left" colspan="1" rowspan="1" valign="top">Groups</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">VAS scores for Female model (Mean &#x00b1; SD)</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">P value</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">VAS scores for Male model (Mean &#x00b1; SD)</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">P value</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Nasolabial angle (+2&#x00b0;)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.56 &#x00b1; 0.705</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.118</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.00 &#x00b1; 0.686
                                <sup>
                                    <bold>a</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="3" valign="top">
                                <bold>0.024</bold>
                                <xref ref-type="table-fn" rid="tfn2">*</xref>
                            </td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.28 &#x00b1; 0.461</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.06 &#x00b1; 0.639
                                <sup>
                                    <bold>a</bold>
                                </sup>
                            </td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.17 &#x00b1; 0.514</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.50 &#x00b1; 0.618
                                <sup>
                                    <bold>b</bold>
                                </sup>
                            </td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Nasolabial angle (+4&#x00b0;)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson
                                <sup>
                                    <bold>b</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.44&#x00b1;0.616</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">
                                <bold>0.023</bold>
                                <xref ref-type="table-fn" rid="tfn2">*</xref>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.72 &#x00b1; 0.826
                                <sup>
                                    <bold>a</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="3" valign="top">
                                <bold>0.032</bold>
                                <xref ref-type="table-fn" rid="tfn2">*</xref>
                            </td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist
                                <sup>
                                    <bold>a</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.50 &#x00b1; 0.618</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.67 &#x00b1; 0.485
                                <sup>
                                    <bold>ab</bold>
                                </sup>
                            </td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist
                                <sup>
                                    <bold>ab</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.00 &#x00b1; 0.485</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.22 &#x00b1; 0.428
                                <sup>
                                    <bold>b</bold>
                                </sup>
                            </td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Nasolabial angle (normal)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.22 &#x00b1; 0.808</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.209</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.56 &#x00b1; 0.616</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.663</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.6 1 &#x00b1; 0.608</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.72 &#x00b1; 0.575</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.39 &#x00b1; 0.502</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.56 &#x00b1; 0.705</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Nasolabial angle (-2&#x00b0;)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.06 &#x00b1; 0.938</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.918</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.11 &#x00b1; 0.963</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.659</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.17 &#x00b1; 0.514</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.17 &#x00b1; 0.618</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.11 &#x00b1; 0.900</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.94 &#x00b1; 0.639</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Nasolabial angle (-4&#x00b0;)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson
                                <sup>
                                    <bold>a</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.72 &#x00b1; 1.227</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">
                                <bold>0.013</bold>
                                <xref ref-type="table-fn" rid="tfn2">*</xref>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.39 &#x00b1; 0.916</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.115</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist
                                <sup>
                                    <bold>b</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.67 &#x00b1; 0.686</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.00 &#x00b1; 0.686</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist
                                <sup>
                                    <bold>b</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1.94 &#x00b1; 0.416</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1.89 &#x00b1; 0.583</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Upper lip to E-line (+1 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.28 &#x00b1; 0.669</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.146</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.22 &#x00b1; 0.808</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.124</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.94 &#x00b1; 0.725</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.17 &#x00b1; 0.618</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.89 &#x00b1; 0.471</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.78 &#x00b1; 0.647</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Upper lip to E-line (+2 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.22 &#x00b1; 0.732</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.098</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.67 &#x00b1; 0.767</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.141</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.94 &#x00b1; 0.725</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.56 &#x00b1; 0.511</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.72 &#x00b1; 0.575</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.28 &#x00b1; 0.461</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Upper lip to E-line (normal)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.67 &#x00b1; 0.686</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">I</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.50 &#x00b1; 0.514</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.172</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.67 &#x00b1; 0.485</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.78 &#x00b1; 0.548</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.67 &#x00b1; 0.686</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.44 &#x00b1; 0.616</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Upper lip to E-line (-1 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson
                                <sup>
                                    <bold>a</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.72 &#x00b1; 0.958</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">
                                <bold>0.044</bold>
                                <xref ref-type="table-fn" rid="tfn2">*</xref>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.l l &#x00b1; 0.758</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.287</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist
                                <sup>
                                    <bold>ab</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.44 &#x00b1; 0.705</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.22 &#x00b1; 0.428</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist
                                <sup>
                                    <bold>b</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.06 &#x00b1; 0.639</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.89 &#x00b1; 0.676</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Upper lip to E-line (-2 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson
                                <sup>
                                    <bold>a</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.50 &#x00b1; 1.043</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">
                                <bold>0.006</bold>
                                <xref ref-type="table-fn" rid="tfn2">*</xref>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.56 &#x00b1; 0.922</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.087</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist
                                <sup>
                                    <bold>ab</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.11 &#x00b1; 0.471</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.56 &#x00b1; 0.511</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist
                                <sup>
                                    <bold>b</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1.67 &#x00b1; 0.594</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.06 &#x00b1; 0.802</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Lower lip to E-line (+1 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.33 &#x00b1; 0.686</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.165</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.39 &#x00b1; 0.608</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.374</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.11 &#x00b1; 0.583</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.39 &#x00b1; 0.502</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.94 &#x00b1; 0.539</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.17&#x00b1;0.514</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Lower lip to E-line (+2 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.72 &#x00b1; 0.958</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.198</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.72 &#x00b1; 0.826</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.421</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.56 &#x00b1; 0.705</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.50 &#x00b1; 0.618</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.28 &#x00b1; 0.461</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.44 &#x00b1; 0.511</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Lower lip to E-line (normal)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson
                                <sup>
                                    <bold>ab</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.89 &#x00b1; 0.583</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">
                                <bold>0.033</bold>
                                <xref ref-type="table-fn" rid="tfn2">*</xref>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.78 &#x00b1; 0.548</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.939</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist
                                <sup>
                                    <bold>b</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.44 &#x00b1;0.511</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.83 &#x00b1; 0.383</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist
                                <sup>
                                    <bold>a</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.50 &#x00b1; 0.514</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.78 &#x00b1; 0.647</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Lower lip to E-line (-1 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson
                                <sup>
                                    <bold>a</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.50 &#x00b1; 0.707</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">
                                <bold>0.003</bold>
                                <xref ref-type="table-fn" rid="tfn2">*</xref>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.50 &#x00b1; 0.707</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.068</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist
                                <sup>
                                    <bold>ab</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.22 &#x00b1; 0.548</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.67 &#x00b1; 0.594</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist
                                <sup>
                                    <bold>b</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.83 &#x00b1; 0.383</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.17 &#x00b1; 0.618</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Lower lip to E-line (-2 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson
                                <sup>
                                    <bold>a</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.28 &#x00b1; 0.895</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">
                                <bold>0.011</bold>
                                <xref ref-type="table-fn" rid="tfn2">*</xref>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.00 &#x00b1; 0.840</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.076</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist
                                <sup>
                                    <bold>b</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.11 &#x00b1; 1.023</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.94 &#x00b1; 0.539</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist
                                <sup>
                                    <bold>b</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.39 &#x00b1; 0.778</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.50 &#x00b1; 0.707</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">pg-pg&#x2019; (+2 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.78 &#x00b1;0.647</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.564</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.78 &#x00b1; 0.548</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.531</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.67 &#x00b1;0.594</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.72 &#x00b1; 0.461</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.56 &#x00b1; 0.616</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.56 &#x00b1; 0.784</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">pg-pg&#x2019; (+4 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson
                                <sup>
                                    <bold>b</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.94 &#x00b1;0.873</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">
                                <bold>0.032</bold>
                                <xref ref-type="table-fn" rid="tfn2">*</xref>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.17&#x00b1;0.786
                                <sup>
                                    <bold>b</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="3" valign="top">
                                <bold>0.016</bold>
                                <xref ref-type="table-fn" rid="tfn2">*</xref>
                            </td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist
                                <sup>
                                    <bold>a</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.17 &#x00b1; 0.618</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.6 I &#x00b1; 0.502
                                <sup>
                                    <bold>a</bold>
                                </sup>
                            </td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist
                                <sup>
                                    <bold>ab</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.56&#x00b1;0.511</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.94 &#x00b1; 0.725
                                <sup>
                                    <bold>ab</bold>
                                </sup>
                            </td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">pg-pg&#x2019; (normal)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson
                                <sup>
                                    <bold>ab</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.67 &#x00b1;0.767</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">
                                <bold>0.026</bold>
                                <xref ref-type="table-fn" rid="tfn2">*</xref>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.61 &#x00b1; 0.502</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.952</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist
                                <sup>
                                    <bold>b</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.11 &#x00b1;0.471</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.6 I &#x00b1; 0.608</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist
                                <sup>
                                    <bold>a</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.56 &#x00b1; 0.616</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.56 &#x00b1; 0.705</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">pg-pg&#x2019; (-2 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.94 &#x00b1; 0.802</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.069</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.50 &#x00b1; 0.857</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.379</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.61 &#x00b1; 0.778</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.44 &#x00b1; 0.511</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.39 &#x00b1; 0.502</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.22 &#x00b1; 0.428</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">pg-pg&#x2019; (-4 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson
                                <sup>
                                    <bold>a</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.50 &#x00b1; 1.043</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">
                                <bold>0.029</bold>
                                <xref ref-type="table-fn" rid="tfn2">*</xref>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.22 &#x00b1; 1.114</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.164</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist
                                <sup>
                                    <bold>ab</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.00 &#x00b1; 0.594</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.00 &#x00b1; 0.485</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist
                                <sup>
                                    <bold>b</bold>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1.83 &#x00b1; 0.514</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1.72 &#x00b1; 0.575</td>
                        </tr>
                    </tbody>
                </table>
                <table-wrap-foot>
                    <fn id="tfn2">
                        <label>*</label>
                        <p>P value &#x2264; 0.05 is considered a statistically significant difference and for post hoc Tukey analysis groups with the same superscripted letter are not significantly different.</p>
                    </fn>
                </table-wrap-foot>
            </table-wrap>
            <p>The results of the Chi-square test for female profiles with Lower lip to E-line (-2 mm), pg-pg&#x2019; (+4 mm), and pg-pg&#x2019; (-4 mm) showed that significantly more orthodontists preferred surgical correction as compared to other groups. Meanwhile, all remaining profiles showed statistically non-significant differences between the three groups. In contrast, for the male profile with Nasolabial angle (+4&#x00b0;), significantly more orthodontists preferred surgery as compared to other groups. The remaining profiles showed statistically non-significant differences between the three groups (
                <xref ref-type="table" rid="T3">Table 3</xref>).</p>
            <table-wrap id="T3" orientation="portrait" position="float">
                <label>Table 3. </label>
                <caption>
                    <title>Results of Chi-square Test for opinion for surgical treatment of three study groups.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="2" valign="top"/>
                            <th align="left" colspan="1" rowspan="2" valign="top">Groups</th>
                            <th align="left" colspan="2" rowspan="1" valign="top">For female model</th>
                            <th align="left" colspan="1" rowspan="2" valign="top">P value</th>
                            <th align="left" colspan="2" rowspan="1" valign="top">For male model</th>
                            <th align="left" colspan="1" rowspan="2" valign="top">P value</th>
                        </tr>
                        <tr>
                            <th align="left" colspan="1" rowspan="1" valign="top">Yes n (%)</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">No n (%)</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Yes n (%)</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">No n (%)</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Nasolabial angle (+2&#x00b0;)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 (5.6%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">17 (94.4%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">1.00</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">5 (27.8%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">13 (72.2%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.424</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 (5.6%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">17 (94.4%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2 (11.1%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">16 (88.9%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 (5.6%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">17 (94.4%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3 (16.7%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">15 (83.3%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Nasolabial angle (+4&#x00b0;)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4 (22.2%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">14 (77.8%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.317</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">10 (55.6%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">8 (44.4%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">
                                <bold>0.053</bold>
                                <xref ref-type="table-fn" rid="tfn3">*</xref>
                            </td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2 (11.1%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">16 (88.9%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3 (16.7%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">15 (83.3%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 (5.6%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">17 (94.4%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">7 (38.9%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">11(61.1%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Nasolabial angle (normal)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 (5.6%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">17 (94.4%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.151</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (100%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">-</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (100%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (100%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3 (16.7%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">15 (83.3%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (100%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Nasolabial angle (-2&#x00b0;)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 (5.6%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">17 (94.4%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.072</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3 (16.7%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">15 (83.3 %)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.381</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 (5.6%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">17 (94.4%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3 (16.7%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">15 (83.3%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">5 (27.8 %)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">13 (72.2%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">6 (33.3%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">12 (66.7%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Nasolabial angle (-4&#x00b0;)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">13(72.2%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">5 (27.8%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.064</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">13 (72.2 %)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">5 (27.8%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.574</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">6 (33.3%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">12 (66.7%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 l (61.1 %)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">7 (38.9%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">10 (55.6%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">8 (44.4%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">10 (55.6%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">8 (44.4%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Upper lip to E-line (+1 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3 (16.7%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">15 (83.3%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.570</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2 (11.1%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">16 (88.9%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.105</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2 (11.1%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">16 (88.9%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>-</bold>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (100%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 (5.6%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">17 (94.4%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4 (22.2%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">14 (77.8%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Upper lip to E-line (+2 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">5 (27.8%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">13 (72.2%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.148</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">10 (55.6%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">8 (44.4%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.407</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2 (11.1%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">16 (88.9%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">6 (33.3%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">12 (66.7%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 (5.6%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">17 (94.4%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">8 (44.4%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">10 (55.6%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Upper lip to E-line (normal)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (100%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.125</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (100%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.361</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (100%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (100%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2 (11.1%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">16 (88.9%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 (5.6%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">17 (94.4%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Upper lip to E-line (-1 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">12 (66.7%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">6 (33.3%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.056</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3 (16.7%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">15 (83.3%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.185</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">5 (27.8%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">13 (72.2%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (100%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">10 (55.6%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">8 (44.4%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3 (16.7%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">15 (83.3%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Upper lip to E-line (-2 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">15 (83.3%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3 (16.7%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.103</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">8 (44.4%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">10 (55.6%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.369</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">9 (50%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">9 (50%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">5 (27.8%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">13 (72.2%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">11(61.l %)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">7 (38.9%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">9 (50%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">9 (50%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Lower lip to E-line (+1 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 (5.6%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">17 (94.4%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.763</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (100%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.125</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 (5.6%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">17 (94.4%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (100%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2 (11.l %)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">16 (88.9%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2 (11.1%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">16 (88.9%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Lower lip to E-line (+2 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">7 (38.9%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">11 (61.1%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.393</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4 (22.2%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">14 (77.8%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.436</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">5 (27.8%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">13 (72.2%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4 (22.2%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">14 (77.8%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">9 (50%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">9 (50%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">7 (38.9%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">11 (61.1 %)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Lower lip to E-line (normal)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (100%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (100%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.361</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (100%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (100%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (100%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 (5.6%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">17 (94.4%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Lower lip to E-line (-1 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 (5.6%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">17 (94.4%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">1.00</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 (5.6%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">17 (94.4%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.347</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 (5.6%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">17 (94.4%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (100%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 (5.6%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">17 (94.4%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2 (11.1%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">16 (88.9 %)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Lower lip to E-line (-2 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">11 (61.1%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">7 (38.9%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">
                                <bold>0.009</bold>
                                <xref ref-type="table-fn" rid="tfn3">*</xref>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">6 (33.3%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">12 (66.7 %)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.368</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4 (22.2%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">14 (77.8%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4 (22.2%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">14 (77.8%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3 (16.7%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">15 (83.3%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">8 (44.4%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">10 (55.6%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">pg-pg&#x2019; (+2 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (100%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (100%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">-</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (100%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (100%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (100%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (100%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">pg-pg&#x2019; (+4 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">7 (38.9%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">11 (61.1%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">
                                <bold>0.05</bold>
                                <xref ref-type="table-fn" rid="tfn3">*</xref>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4 (22.2%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">14 (77.8%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.057</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 (5.6%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">17 (94.4%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 (5.6%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">17 (94.4%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">6 (33.3%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">12 (66.7%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (100%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">pg-pg&#x2019; (normal)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (100%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.361</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (100%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">-</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (100%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (100%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 (5.6%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">17 (94.4%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (100%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">pg-pg&#x2019; (-2 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">9 (50%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">9 (50%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.105</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">10 (55.6%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">8 (44.4%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.743</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3 (16.7%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">15 (83.3%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">8 (44.4%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">10 (55.6%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">6 (33.3 %)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">12 (66.7%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">10 (55.6%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">8 (44.4%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">pg-pg&#x2019; (-4 mm)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Orthodontist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">17 (94.4%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 (5.6%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">
                                <bold>0.022</bold>
                                <xref ref-type="table-fn" rid="tfn3">*</xref>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">16 (88.9%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2(11.1%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.301</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">General Dentist</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">11(6 1.1%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">7 (38.9%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">16 (88.9%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2(11.1%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Layperson</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">10 (55.6%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">8 (44.4%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">13 (72.2 %)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">S (27.8%)</td>
                        </tr>
                    </tbody>
                </table>
                <table-wrap-foot>
                    <fn id="tfn3">
                        <label>*</label>
                        <p>P value &#x2264; 0.05 is considered a statistically significant difference.</p>
                    </fn>
                </table-wrap-foot>
            </table-wrap>
        </sec>
        <sec id="sec5" sec-type="discussion">
            <title>Discussion</title>
            <p>In the present study, we evaluated the esthetic perceptions of different patient profiles from the standpoint of orthodontists, general dentists, and laypersons. The results showed an overall weak negative correlation between the three groups, which indicates that orthodontists attributed lower pleasantness scores to almost all the female and male facial profiles on the visual analog scale. Further, the results of ANOVA also showed that Orthodontists significantly attributed lower pleasantness scores to many females and few male facial profiles. Correspondingly, a similar study done by Volpato GM 
                <italic toggle="yes">et al.</italic> reported that patients and lay people assigned higher pleasantness scores than orthodontists, with statistically significant differences for all evaluations.
                <sup>
                    <xref ref-type="bibr" rid="ref11">11</xref>
                </sup> Lines 
                <italic toggle="yes">et al.</italic> and Imani 
                <italic toggle="yes">et al.</italic> in their studies comparing judgments by orthodontists, general surgeons, other dental professionals, and laypersons, stated that even though the orthodontists&#x2019; group were more precise in their judgments when compared to oral surgeons, but their opinions still differed greatly from those of laypersons and other dental professionals.
                <sup>
                    <xref ref-type="bibr" rid="ref12">12</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref13">13</xref>
                </sup> In addition, as noticed in the present study, Romani 
                <italic toggle="yes">et al.</italic> and Burcal 
                <italic toggle="yes">et al.</italic>, specified that irrespective of the educational level the facial profiles of the female patients were judged more carefully.
                <sup>
                    <xref ref-type="bibr" rid="ref14">14</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref15">15</xref>
                </sup>
            </p>
            <p>In facial profiles with increased nasolabial angle by +4&#x00b0; and decreased nasolabial angle by -4&#x00b0;, orthodontists gave lower scores than the other two study groups for both female and male profiles. For a female profile where the lower component of the nasolabial angle was decreased by 2 degrees, a weak positive correlation or a fair agreement was seen between all three groups, as most of them agreed it to be an attractive profile. According to Farhad B. Naini 
                <italic toggle="yes">et al.,</italic>
                <sup>
                    <xref ref-type="bibr" rid="ref16">16</xref>
                </sup> an upper lip inclination of 79&#x00b0;-85&#x00b0; is regarded as ideal, while a range of 73&#x00b0;-88&#x00b0; is considered acceptable. Angles lower than 67&#x00b0; and greater than 94&#x00b0; are considered slightly unappealing, and any angle exceeding the range of 67&#x00b0;-94&#x00b0; is considered very unattractive. Burnstone
                <sup>
                    <xref ref-type="bibr" rid="ref17">17</xref>
                </sup> stressed the importance of this angle since laypeople were more likely to evaluate upper lip protrusion in relation to the nose.</p>
            <p>For female profiles where the upper lip E-line was decreased by 1 mm and 2 mm, and the lower lip E-line decreased by 1 mm and 2 mm, significantly more orthodontists than general dentists or laypeople felt the profiles to be unattractive as these profiles became a little convex. Similarly, for profiles of both females and males where the upper lip E-line was increased by 1 mm and 2 mm, orthodontists and general dentists gave lower scores. They felt these profiles were unattractive as they became close to class II or convex profiles. According to Young-Chel Park and Charles J Burnstone,
                <sup>
                    <xref ref-type="bibr" rid="ref18">18</xref>
                </sup> the upper lip E-line in the normal occlusion group is -4.8 mm, and the lower lip E-line is -3.8 mm.</p>
            <p>Most of the study participants gave higher scores for both female and male profiles where the soft tissue pogonion (pg-pg&#x2019;) was increased by 2 mm. This implied that most of them might prefer a slightly concave profile to be more esthetic. Again, for the profiles of both female and male models where the soft tissue pogonion (pg-pg&#x2019;) was increased by 4 mm (as it became more class III as well as deemed unappealing) and for a profile where soft tissue pogonion (pg-pg&#x2019;) was decreased by 4 mm, most of the orthodontists significantly considered these profiles unattractive. Additionally, it showed a maximum disparity in orthodontists&#x2019; perception compared to both groups. The level of training and experience among orthodontists and general dentists may differ, potentially influencing their esthetic judgments. According to Park and Burnstone, pg-pg&#x2019; was found to be 12.2 mm in the normal group and increased to 13.2 mm in class II division 1 patients; mean values for females were 12.6 mm and 13 mm for males. In the original profile of male and female study models with normal pg-pg&#x2019;, all three groups felt the profiles average or good-looking.
                <sup>
                    <xref ref-type="bibr" rid="ref18">18</xref>
                </sup>
            </p>
            <p>Regarding perceptions of the groups for oral surgery, significantly more orthodontists considered the need for surgery to improve the facial esthetics for a female profile with the lower lip E-line decreased by 2 mm. Similarly, in the female profiles where the soft tissue pogonion (pg-pg&#x2019;) was increased by 4 mm and decreased by 4 mm, most of the orthodontists believed these profiles needed surgery compared to other groups. It was noticed that although there was no statistically significant difference for the profiles with a decreased 2 mm from the upper lip E-line and a decreased 2 mm from the Lower lip E-line, more orthodontists preferred surgery. Perceptions of different groups for assessing the need for surgery for male profiles found that significantly more orthodontists preferred surgery for a profile where the nasolabial angle was increased by 4 degrees compared to other groups. Also, more orthodontists preferred surgery for the profiles with decreased nasolabial angle by -4&#x00b0; for both males and females as the profiles became more class II and convex. It was noticed that for most of the original study model profiles, and a profile with soft tissue pogonion (pg-pg&#x2019;) increased by 2 mm, almost 100% percent of them felt that surgery was not required to improve the facial esthetics. DeAlmeida and Bittencourt in their study stated that surgery was indicated mainly for the convex profiles for males and concave profiles for females.
                <sup>
                    <xref ref-type="bibr" rid="ref19">19</xref>
                </sup>
            </p>
            <p>Limitations: Esthetic preferences are inherently subjective, and individual biases may affect responses, leading to variability in preferences that may not reflect a consensus. Cultural norms and values can influence esthetic preferences. The study may not account for regional or cultural differences in beauty standards, potentially limiting the applicability of the findings across diverse populations. These limitations highlight the importance of carefully interpreting and considering the results alongside other research for a more comprehensive understanding.</p>
            <p>Recommendations: Further studies can compare findings with other cultural contexts to explore how aesthetic preferences differ globally. Incorporating qualitative methods, such as interviews or focus groups, is recommended to gain deeper insights into the reasoning behind esthetic preferences. It is also recommended to utilize 3D imaging or virtual simulations to enhance the assessment of facial profiles and allow participants to visualize changes more effectively. Implementing these recommendations could enhance the robustness and applicability of future research in esthetic preferences.</p>
        </sec>
        <sec id="sec6" sec-type="conclusions">
            <title>Conclusions</title>
            <p>Hence, it was concluded that participants in the three groups had diverse conceptions of facial attractiveness in all parameters considered. Compared to general dentists and laypersons, orthodontists were much more precise, firmer, and meticulous in identifying a favorable or good-looking profile. In the present study, orthodontists attributed lower pleasantness scores to almost all the altered female and male facial profiles. The study results also indicate that although more orthodontists identified the need for surgical correction for a few severely distorted profiles, there was a statistically non-significant difference between the groups for most of the altered profiles. Since esthetics is subjective and leads to different facial evaluations, orthodontists must address patients&#x2019; esthetic concerns for satisfactory treatment outcomes.</p>
        </sec>
        <sec id="sec7">
            <title>Informed consent</title>
            <p>We confirm that we have obtained permission to use images and data from the participants included in this work.</p>
        </sec>
    </body>
    <back>
        <sec id="sec10" sec-type="data-availability">
            <title>Data availability</title>
            <sec id="sec11">
                <title>Underlying data</title>
                <p>Mendeley Data: Esthetic Preferences of Orthodontists, general dentists, and Laypersons for Indian facial profiles: A cross-sectional study, 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.17632/b9tkhwjhjb.1">https://doi.org/10.17632/b9tkhwjhjb.1</ext-link>.
                    <sup>

                        <xref ref-type="bibr" rid="ref20">20</xref>
</sup>
                </p>
                <p>This project contains the following underlying data:
                    <list list-type="bullet">
                        <list-item>
                            <label>-</label>
                            <p>Raw Data - Aesthetic Preferences of various study groups.xlsx
</p>
                        </list-item>
                    </list>
                </p>
                <p>Data are available under the terms of the 
                    <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International license</ext-link> (CC-BY 4.0).</p>
            </sec>
        </sec>
        <ref-list>
            <title>References</title>
            <ref id="ref1">
                <label>1</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Nash</surname>
                            <given-names>DA</given-names>
                        </name>
</person-group>:
                    <article-title>Professional ethics and esthetic dentistry.</article-title>
                    <source>

                        <italic toggle="yes">J Am Dent Assoc.</italic>
</source>
                    <year>2001</year>;<volume>132</volume>:<fpage>39</fpage>&#x2013;<lpage>45</lpage>.</mixed-citation>
            </ref>
            <ref id="ref2">
                <label>2</label>
                <mixed-citation publication-type="book">
                    <source>

                        <italic toggle="yes">Routledge Encyclopedia of Philosophy.</italic>
</source>
                    <publisher-loc>London</publisher-loc>:
                    <publisher-name>Malcolm Budd</publisher-name>;<year>1998</year>. Aesthetics; (cited 2023, May 25).</mixed-citation>
            </ref>
            <ref id="ref3">
                <label>3</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Basciftci</surname>
                            <given-names>FA</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Uysal</surname>
                            <given-names>T</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Buyukerkmen</surname>
                            <given-names>A</given-names>
                        </name>
</person-group>:
                    <article-title>Determination of Holdaway soft tissue norms in Anatolian Turkish adults.</article-title>
                    <source>

                        <italic toggle="yes">Am J Orthod Dentofacial Orthop.</italic>
</source>
                    <year>2003</year>;<volume>123</volume>:<fpage>395</fpage>&#x2013;<lpage>400</lpage>.
                    <pub-id pub-id-type="pmid">12695766</pub-id>
                    <pub-id pub-id-type="doi">10.1067/mod.2003.139</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref4">
                <label>4</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Chan</surname>
                            <given-names>LMV</given-names>
                        </name>
</person-group>:
                    <article-title>Foot binding in Chinese women and its psycho-social implications.</article-title>
                    <source>Can Psychiatr Assoc J.</source>
                    <year>1970</year>;<volume>15</volume>(<issue>2</issue>):<fpage>229</fpage>&#x2013;<lpage>232</lpage>.
                    <pub-id pub-id-type="pmid">5478606</pub-id>
                    <pub-id pub-id-type="doi">10.1177/070674377001500218</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref5">
                <label>5</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Abrahams</surname>
                            <given-names>R</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Kamath</surname>
                            <given-names>G</given-names>
                        </name>
</person-group>:
                    <article-title>Midline diastema and its aetiology - A review.</article-title>
                    <source>

                        <italic toggle="yes">Dental Update.</italic>
</source>
                    <year>2014</year>;<volume>41</volume>(<issue>5</issue>):<fpage>457</fpage>&#x2013;<lpage>464</lpage>.
                    <pub-id pub-id-type="pmid">25073229</pub-id>
                    <pub-id pub-id-type="doi">10.12968/denu.2014.41.5.457</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref6">
                <label>6</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Peck</surname>
                            <given-names>S</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Peck</surname>
                            <given-names>L</given-names>
                        </name>
</person-group>:
                    <article-title>Selected aspects of the art and science of facial esthetics.</article-title>
                    <source>

                        <italic toggle="yes">Semin Orthod.</italic>
</source>
                    <year>1995</year>;<volume>1</volume>(<issue>1</issue>):<fpage>105</fpage>&#x2013;<lpage>126</lpage>.
                    <pub-id pub-id-type="doi">10.1016/S1073-8746(95)80097-2</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref7">
                <label>7</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Holdaway</surname>
                            <given-names>RA</given-names>
                        </name>
</person-group>:
                    <article-title>Soft tissue cephalometric analysis and its use in orthodontic treatment planning.</article-title>
                    <source>

                        <italic toggle="yes">Am J Orthod.</italic>
</source>
                    <year>1983</year>;<volume>84</volume>:<fpage>1</fpage>&#x2013;<lpage>28</lpage>.
                    <pub-id pub-id-type="pmid">6575614</pub-id>
                    <pub-id pub-id-type="doi">10.1016/0002-9416(83)90144-6</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref8">
                <label>8</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Ricketts</surname>
                            <given-names>RM</given-names>
                        </name>
</person-group>:
                    <article-title>The biologic significance of divine proportion and Fibonacci series.</article-title>
                    <source>

                        <italic toggle="yes">Am J Orthod.</italic>
</source>
                    <year>1982</year>;<volume>81</volume>:<fpage>351</fpage>&#x2013;<lpage>370</lpage>.
                    <pub-id pub-id-type="doi">10.1016/0002-9416(82)90073-2</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref9">
                <label>9</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Arnett</surname>
                            <given-names>GW</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Bergman</surname>
                            <given-names>RT</given-names>
                        </name>
</person-group>:
                    <article-title>Facial keys to orthodontic diagnosis and treatment planning. Part I.</article-title>
                    <source>

                        <italic toggle="yes">Am J Orthod Dentofacial Orthop.</italic>
</source>
                    <year>1993 Apr</year>;<volume>103</volume>(<issue>4</issue>):<fpage>299</fpage>&#x2013;<lpage>312</lpage>.
                    <pub-id pub-id-type="pmid">8480695</pub-id>
                    <pub-id pub-id-type="doi">10.1016/0889-5406(93)70010-L</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref10">
                <label>10</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Arnett</surname>
                            <given-names>GW</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Bergman</surname>
                            <given-names>RT</given-names>
                        </name>
</person-group>:
                    <article-title>Facial keys to orthodontic diagnosis and treatment planning. Part 2.</article-title>
                    <source>

                        <italic toggle="yes">Am J Orthod Dentofacial Orthop.</italic>
</source>
                    <year>1993 May</year>;<volume>103</volume>(<issue>5</issue>):<fpage>395</fpage>&#x2013;<lpage>411</lpage>.
                    <pub-id pub-id-type="pmid">8480709</pub-id>
                    <pub-id pub-id-type="doi">10.1016/s0889-5406(05)81791-3</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref11">
                <label>11</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Volpato</surname>
                            <given-names>GH</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Rodrigues</surname>
                            <given-names>R</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Almeida-Pedrin</surname>
                            <given-names>P</given-names>
                            <prefix>de</prefix>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Self-perception of facial esthetics by patients with different profiles compared with assessments of orthodontists and lay people.</article-title>
                    <source>

                        <italic toggle="yes">Am J Orthod Dentofacial Orthop.</italic>
</source>
                    <year>2020</year>;<volume>158</volume>(<issue>6</issue>):<fpage>840</fpage>&#x2013;<lpage>848</lpage>.
                    <pub-id pub-id-type="pmid">33256916</pub-id>
                    <pub-id pub-id-type="doi">10.1016/j.ajodo.2019.10.027</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref12">
                <label>12</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Lines</surname>
                            <given-names>PA</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Lines</surname>
                            <given-names>RR</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Lines</surname>
                            <given-names>CA</given-names>
                        </name>
</person-group>:
                    <article-title>Profile metrics and facial esthetics.</article-title>
                    <source>

                        <italic toggle="yes">Am J Orthod.</italic>
</source>
                    <year>1978</year>;<volume>73</volume>:<fpage>648</fpage>&#x2013;<lpage>657</lpage>.
                    <pub-id pub-id-type="pmid">276268</pub-id>
                    <pub-id pub-id-type="doi">10.1016/0002-9416(78)90225-7</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref13">
                <label>13</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Imani</surname>
                            <given-names>MM</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Sanei</surname>
                            <given-names>E</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Niaki</surname>
                            <given-names>EA</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Esthetic preferences of orthodontists, oral surgeons, and laypersons for Persian facial profiles.</article-title>
                    <source>

                        <italic toggle="yes">Am J Orthod Dentofacial Orthop.</italic>
</source>
                    <year>2018</year>;<volume>154</volume>:<fpage>412</fpage>&#x2013;<lpage>420</lpage>.
                    <pub-id pub-id-type="pmid">30173845</pub-id>
                    <pub-id pub-id-type="doi">10.1016/j.ajodo.2017.11.040</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref14">
                <label>14</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Romani</surname>
                            <given-names>KL</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Agahi</surname>
                            <given-names>F</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Nanda</surname>
                            <given-names>R</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Evaluation of horizontal and vertical differences in facial profiles by orthodontists and lay people.</article-title>
                    <source>

                        <italic toggle="yes">Angle Orthod.</italic>
</source>
                    <year>1993</year>;<volume>63</volume>:<fpage>175</fpage>&#x2013;<lpage>182</lpage>.
                    <pub-id pub-id-type="pmid">8214785</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref15">
                <label>15</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Burcal</surname>
                            <given-names>RG</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Laskin</surname>
                            <given-names>DM</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Sperry</surname>
                            <given-names>TP</given-names>
                        </name>
</person-group>:
                    <article-title>Recognition of profile change after simulated orthognathic surgery.</article-title>
                    <source>

                        <italic toggle="yes">J Oral Maxillofac Surg.</italic>
</source>
                    <year>1987</year>;<volume>45</volume>:<fpage>666</fpage>&#x2013;<lpage>670</lpage>.
                    <pub-id pub-id-type="pmid">3475437</pub-id>
                    <pub-id pub-id-type="doi">10.1016/0278-2391(87)90304-1</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref16">
                <label>16</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Naini</surname>
                            <given-names>FB</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Cobourne</surname>
                            <given-names>MT</given-names>
                        </name>
</person-group>:
                    <article-title>Fraser McDonald, and David Wertheim the aesthetic impact of upper lip inclination in orthodontics and orthognathic surgery.</article-title>
                    <source>

                        <italic toggle="yes">Eur J Orthod.</italic>
</source>
                    <year>2015</year>;<volume>37</volume>:<fpage>81</fpage>&#x2013;<lpage>86</lpage>.
                    <pub-id pub-id-type="pmid">25016578</pub-id>
                    <pub-id pub-id-type="doi">10.1093/ejo/cju015</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref17">
                <label>17</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Burstone</surname>
                            <given-names>CJ</given-names>
                        </name>
</person-group>:
                    <article-title>Lip Posture and Its Significance in Treatment Planning.</article-title>
                    <source>

                        <italic toggle="yes">Am. J. Orthod.</italic>
</source>
                    <year>1967</year>;<volume>53</volume>:<fpage>262</fpage>&#x2013;<lpage>284</lpage>.
                    <pub-id pub-id-type="pmid">5227460</pub-id>
                    <pub-id pub-id-type="doi">10.1016/0002-9416(67)90022-X</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref18">
                <label>18</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Park</surname>
                            <given-names>YC</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Burstone</surname>
                            <given-names>CJ</given-names>
                        </name>
</person-group>:
                    <article-title>Soft-tissue profile -Fallacies of hard-tissue standards in treatment planning.</article-title>
                    <source>

                        <italic toggle="yes">Am J Orthod.</italic>
</source>
                    <year>1986</year>;<volume>90</volume>:<fpage>52</fpage>&#x2013;<lpage>62</lpage>.
                    <pub-id pub-id-type="doi">10.1016/0889-5406(86)90027-2</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref19">
                <label>19</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>De Almeida</surname>
                            <given-names>MD</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Bittencourt</surname>
                            <given-names>MA</given-names>
                        </name>
</person-group>:
                    <article-title>Anteroposterior position of mandible and perceived need for orthognathic surgery.</article-title>
                    <source>

                        <italic toggle="yes">J Oral Maxillofac Surg.</italic>
</source>
                    <year>2009</year>;<volume>67</volume>:<fpage>73</fpage>&#x2013;<lpage>82</lpage>.
                    <pub-id pub-id-type="pmid">19070751</pub-id>
                    <pub-id pub-id-type="doi">10.1016/j.joms.2008.06.049</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref20">
                <label>20</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Singla</surname>
                            <given-names>R</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Reddy</surname>
                            <given-names>H</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Singla</surname>
                            <given-names>N</given-names>
                        </name>
</person-group>:
                    <article-title>Esthetic Preferences of Orthodontists, general dentists, and Laypersons for Indian facial profiles: A cross-sectional study.</article-title>
                    <source>

                        <italic toggle="yes">Mendeley Data.</italic>
</source>
                    <year>2023</year>;<volume>V1</volume>.
                    <pub-id pub-id-type="doi">10.17632/b9tkhwjhjb.1</pub-id>
                </mixed-citation>
            </ref>
        </ref-list>
    </back>
    <sub-article article-type="reviewer-report" id="report328130">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.172422.r328130</article-id>
            <title-group>
                <article-title>Reviewer response for version 2</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Tew</surname>
                        <given-names>In Meei</given-names>
                    </name>
                    <xref ref-type="aff" rid="r328130a1">1</xref>
                    <role>Referee</role>
                </contrib>
                <aff id="r328130a1">
                    <label>1</label>Department of Restorative Dentistry, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>10</day>
                <month>10</month>
                <year>2024</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2024 Tew IM</copyright-statement>
                <copyright-year>2024</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport328130" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.138742.2"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>The authors have addressed all the previous comments, &#x00a0;but I have a few additional suggestions for authors' consideration:</p>
            <p> i) suggest to remove the word "Limitation:" and add one sentence at the beginning of the paragraph. For example: This study has several limitations......"</p>
            <p> ii) suggest to remove the word "recommendations:"&#x00a0;</p>
            <p> </p>
            <p> Otherwise, this revised manuscript will be ready to be indexed.</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Yes</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Yes</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Yes</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Yes</p>
            <p>Reviewer Expertise:</p>
            <p>NA</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.</p>
        </body>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report328129">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.172422.r328129</article-id>
            <title-group>
                <article-title>Reviewer response for version 2</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Rokaya</surname>
                        <given-names>Dinesh</given-names>
                    </name>
                    <xref ref-type="aff" rid="r328129a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-3854-667X</uri>
                </contrib>
                <aff id="r328129a1">
                    <label>1</label>Walailak University, Thai Buri, Nakhon Si Thammarat, Thailand</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>4</day>
                <month>10</month>
                <year>2024</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2024 Rokaya D</copyright-statement>
                <copyright-year>2024</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport328129" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.138742.2"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>The authors&#x00a0; have corrected the article and it can be accepted.</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Partly</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Yes</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Partly</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>No</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Partly</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Reviewer Expertise:</p>
            <p>Prosthodontics, Esthetic Dentistry, Biomaterials</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.</p>
        </body>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report222335">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.151968.r222335</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Tekale</surname>
                        <given-names>Pawankumar</given-names>
                    </name>
                    <xref ref-type="aff" rid="r222335a1">1</xref>
                    <role>Referee</role>
                </contrib>
                <aff id="r222335a1">
                    <label>1</label>Dr. Rajesh Ramdasji Kambe Dental College and Hospital, Maharashtra, India</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>3</day>
                <month>7</month>
                <year>2024</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2024 Tekale P</copyright-statement>
                <copyright-year>2024</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport222335" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.138742.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>Overall research is nice. This study would have given more valuable conclusive inputs if the sample size could have been 25-30 in each group. Furthermore, recent references need to be added. As only a couple of reference articles between 2020 to 2024 and 3 articles between 2010 to 2020. Please try to remove citations from the conclusion and reframe the conclusion in a single paragraph with 4-5 lines only so that researchers and clinicians will be able to line up the clinical implications.</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Yes</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Yes</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Yes</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Yes</p>
            <p>Reviewer Expertise:</p>
            <p>I am a researcher and clinician in orthodontics specialty</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.</p>
        </body>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report242357">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.151968.r242357</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Rokaya</surname>
                        <given-names>Dinesh</given-names>
                    </name>
                    <xref ref-type="aff" rid="r242357a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-3854-667X</uri>
                </contrib>
                <aff id="r242357a1">
                    <label>1</label>Walailak University, Thai Buri, Nakhon Si Thammarat, Thailand</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>20</day>
                <month>2</month>
                <year>2024</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2024 Rokaya D</copyright-statement>
                <copyright-year>2024</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport242357" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.138742.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>reject</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>This is an interesting study where the researchers compared the perceptions of a group of orthodontists, general dentists, and laypersons about the attractiveness of Indian facial profiles.</p>
            <p> Some Comments.</p>
            <p> There exist differences in facial aesthetics measurements in males and females. Please refer to the article (Shah P. et. al, 2022 [ref 1]).</p>
            <p> Considering the objective of this study, the total sample size is only 54 (18 subjects in each group). It would have been better if they had included more samples in each group. The authors need to mention how they calculate the sample size. Which formula or software they used?</p>
            <p> Was the questionnaire used in this study taken from other sources or self-made? Was the questionnaire validated? Please explain.</p>
            <p> Add the inclusion criteria of the subjects.</p>
            <p> Can this study be generalized?</p>
            <p> If this study is conducted in larger samples or different settings, will the results be the same or changed? Please discuss.</p>
            <p> Add limitations of this research.</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Partly</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Yes</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Partly</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>No</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Partly</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Reviewer Expertise:</p>
            <p>Prosthodontics, Esthetic Dentistry, Biomaterials</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above.</p>
        </body>
        <back>
            <ref-list>
                <title>References</title>
                <ref id="rep-ref-242357-1">
                    <label>1</label>
                    <mixed-citation publication-type="journal">
                        <person-group person-group-type="author"/>:
                        <article-title>Facial Esthetic Analysis of Nepalese Subjects</article-title>.
                        <source>
                            <italic>The Open Dentistry Journal</italic>
                        </source>.<year>2022</year>;<volume>16</volume>(<issue>1</issue>) :
                        <elocation-id>10.2174/18742106-v16-e2111191</elocation-id>
                        <pub-id pub-id-type="doi">10.2174/18742106-v16-e2111191</pub-id>
                    </mixed-citation>
                </ref>
            </ref-list>
        </back>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report209431">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.151968.r209431</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Tew</surname>
                        <given-names>In Meei</given-names>
                    </name>
                    <xref ref-type="aff" rid="r209431a1">1</xref>
                    <role>Referee</role>
                </contrib>
                <aff id="r209431a1">
                    <label>1</label>Department of Restorative Dentistry, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>16</day>
                <month>10</month>
                <year>2023</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2023 Tew IM</copyright-statement>
                <copyright-year>2023</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport209431" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.138742.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>This is a cross-sectional study on the comparison of esthetic preferences of orthodontists, general dentists, and laypersons for Indian facial profiles. It is generally well written, but there are some comments or suggestions for authors' kind consideration:</p>
            <p> </p>
            <p> Abstract:</p>
            <p> </p>
            <p> Methods:</p>
            <p> </p>
            <p> There are a few sentences required modification for further clarification: 
                <list list-type="order">
                    <list-item>
                        <p>A visual analog scale (VAS) along with a question about surgical correction opinion was given to 18 orthodontists, 18 general dentists, and 18 laypersons to score (1-5) from least to most attractive.</p>
                    </list-item>
                    <list-item>
                        <p>Spearman&#x2019;s rank correlation was computed to assess correlation, as well as ANOVA, followed by 
                            <italic>post hoc </italic>Tukey analysis to compare the mean scores, and Chi-square test to determine the opinion about surgical treatment.</p>
                    </list-item>
                </list> Introduction: 
                <list list-type="bullet">
                    <list-item>
                        <p>suggest to remove first paragraph as the contents have been well covered in second paragraph</p>
                    </list-item>
                </list> Statistical data analysis: 
                <list list-type="bullet">
                    <list-item>
                        <p>Need a further clarification on &#x201c;orthodontic education&#x201d; in the second sentence.</p>
                    </list-item>
                    <list-item>
                        <p>Table 1 to Table 3: Kindly place the * behind the value which is less than 0.05 in the Table.</p>
                    </list-item>
                </list> </p>
            <p> Discussion:</p>
            <p> </p>
            <p> Kindly include the study limitations and further recommendation at the last paragraph.</p>
            <p> </p>
            <p> Conclusions:</p>
            <p> </p>
            <p> Kindly provide a concise conclusion which match with the objective of the study</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Yes</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Yes</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Yes</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Yes</p>
            <p>Reviewer Expertise:</p>
            <p>Prosthodontics</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
        <sub-article article-type="response" id="comment12514-209431">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Singla</surname>
                            <given-names>Nishu</given-names>
                        </name>
                        <aff>Public Health Dentistry, Manipal Academy of Higher Education, Manipal, Karnataka, India</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>24</day>
                    <month>9</month>
                    <year>2024</year>
                </pub-date>
            </front-stub>
            <body>
                <p>I have corrected the manuscript per&#x00a0;
                    <bold>In Meei Tew's&#x00a0;</bold>suggestions&#x00a0;from the&#x00a0;Department of Restorative Dentistry, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.</p>
                <p> I have made the following changes to the article&#x00a0;
                    <bold>"Esthetic Preferences of Orthodontists, General Dentists, and Laypersons for Indian Facial Profiles: A Cross-sectional Study."</bold>&#x00a0; &#x00a0;</p>
                <p> Abstract: no change</p>
                <p> Introduction: Grammatical corrections done</p>
                <p> </p>
                <p> Methods: Rephrased the sentences as suggested by the reviewer.&#x00a0;</p>
                <p> </p>
                <p> Statistical data analysis: Clarification on &#x201c;orthodontic education&#x201d; in the second sentence.</p>
                <p> </p>
                <p> Table 1 to Table 3: Placed the * behind the value, which is less than 0.05, in the tables.</p>
                <p> Discussion: The study limitations and&#x00a0;recommendations are now included in&#x00a0;the last paragraph.</p>
                <p> </p>
                <p> Conclusions: The conclusion is corrected&#x00a0;according to&#x00a0;the objectives.</p>
            </body>
        </sub-article>
    </sub-article>
</article>
