<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN" "http://jats.nlm.nih.gov/publishing/1.2/JATS-journalpublishing1.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="research-article" dtd-version="1.2" xml:lang="en">
    <front>
        <journal-meta>
            <journal-id journal-id-type="pmc">F1000Research</journal-id>
            <journal-title-group>
                <journal-title>F1000Research</journal-title>
            </journal-title-group>
            <issn pub-type="epub">2046-1402</issn>
            <publisher>
                <publisher-name>F1000 Research Limited</publisher-name>
                <publisher-loc>London, UK</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="doi">10.12688/f1000research.153956.1</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Research Article</subject>
                </subj-group>
                <subj-group>
                    <subject>Articles</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Perceptions and attitudes of medical students and doctors on Euthanasia</article-title>
                <fn-group content-type="pub-status">
                    <fn>
                        <p>[version 1; peer review: 2 not approved]</p>
                    </fn>
                </fn-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Motappa</surname>
                        <given-names>Rohith</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Project Administration</role>
                    <role content-type="http://credit.niso.org/">Software</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-8939-2850</uri>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="yes">
                    <name>
                        <surname>Mallya</surname>
                        <given-names>Ajay</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-2280-3176</uri>
                    <xref ref-type="corresp" rid="c1">a</xref>
                    <xref ref-type="aff" rid="a2">2</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Guleria</surname>
                        <given-names>Meghna</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Project Administration</role>
                    <role content-type="http://credit.niso.org/">Software</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="aff" rid="a3">3</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Singhal</surname>
                        <given-names>Aditi</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Software</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <xref ref-type="aff" rid="a3">3</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Nambiar</surname>
                        <given-names>Pallavi</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Funding Acquisition</role>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="aff" rid="a3">3</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Gaiha</surname>
                        <given-names>Vaibhavi</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Software</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="aff" rid="a3">3</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Kotian</surname>
                        <given-names>Himani</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-1252-507X</uri>
                    <xref ref-type="aff" rid="a2">2</xref>
                </contrib>
                <aff id="a1">
                    <label>1</label>Department of Community Medicine, Rajajinagar, ESIC Medical College &amp; PGIMSR and Model Hospital, Bangalore, Karnataka, 560010, India</aff>
                <aff id="a2">
                    <label>2</label>Community Medicine, Kasturba Medical College, Mangalore, Karnataka, 575001, India</aff>
                <aff id="a3">
                    <label>3</label>Kasturba Medical College, Mangalore, Karnataka, 575001, India</aff>
            </contrib-group>
            <author-notes>
                <corresp id="c1">
                    <label>a</label>
                    <email xlink:href="mailto:ajay.mallya@manipal.edu">ajay.mallya@manipal.edu</email>
                </corresp>
                <fn fn-type="conflict">
                    <p>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>5</day>
                <month>9</month>
                <year>2024</year>
            </pub-date>
            <pub-date pub-type="collection">
                <year>2024</year>
            </pub-date>
            <volume>13</volume>
            <elocation-id>1009</elocation-id>
            <history>
                <date date-type="accepted">
                    <day>23</day>
                    <month>8</month>
                    <year>2024</year>
                </date>
            </history>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2024 Motappa R et al.</copyright-statement>
                <copyright-year>2024</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <self-uri content-type="pdf" xlink:href="https://f1000research.com/articles/13-1009/pdf"/>
            <abstract>
                <sec>
                    <title>Background</title>
                    <p>The concept of euthanasia has recently come into the spotlight, and cases such as those of Aruna Shanbaug have heavily influenced people&#x2019;s opinions on the topic. Whether euthanasia is performed with the intention of ending suffering that otherwise cannot be helped should truly be supported. The thoughts on this topic- especially of those who work closely with patients who suffer from terminal illnesses- healthcare providers must be analyzed. Their perception and views on legalizing the procedure and their hesitancy or lack thereof to perform such a procedure would give the rest of the world a clearer picture- a better standpoint to understand what to do. This study attempted to quantify and analyze the views of doctors and medical students regarding euthanasia.</p>
                </sec>
                <sec>
                    <title>Methods</title>
                    <p>A cross-sectional survey of 212 doctors and medical students at a private medical college in South India was conducted to determine their attitudes toward euthanasia.</p>
                </sec>
                <sec>
                    <title>Results</title>
                    <p>Most participants (66%) supported the practice of euthanasia. The majority of participants also believed that euthanasia should only be performed with the explicit consent of the patient (71.7%). It was also observed that those who had heard about euthanasia via hearsay mostly agreed that it must only be performed with the explicit consent of the patient. Moreover, the study showed that those who had heard about it from hearsay and news mostly stood for it.</p>
                </sec>
                <sec>
                    <title>Conclusion</title>
                    <p>It has been noted that news and media all around us heavily influence people&#x2019;s opinions. It is concluded that these opinions have changed from the past, and will likely do so depending on the environment and media around the topic.</p>
                </sec>
            </abstract>
            <kwd-group kwd-group-type="author">
                <kwd>Euthanasia</kwd>
                <kwd>legalization</kwd>
                <kwd>healthcare providers</kwd>
            </kwd-group>
            <funding-group>
                <funding-statement>The author(s) declared that no grants were involved in supporting this work.</funding-statement>
            </funding-group>
        </article-meta>
    </front>
    <body>
        <sec id="sec5" sec-type="intro">
            <title>Introduction</title>
            <p>Medical care has advanced several times in the last century, especially in the last few decades. These advances have led to the increased longevity of multiple diseases. On an equal footing, there is an ever-increasing awareness of quality of life. People are becoming cognizant of their right to make decisions not only in their options regarding treatment, but also in their choice to end their lives. Euthanasia is defined as an easy or painless death or intentional ending of the life of a person suffering from an incurable or painful disease at his or her request.
                <sup>
                    <xref ref-type="bibr" rid="ref1">1</xref>
                </sup> It is of two types: active euthanasia, where the physician directly administers a lethal medication and ends a patient&#x2019;s life, or passive euthanasia, where a patient is allowed to die by witholding life support.
                <sup>
                    <xref ref-type="bibr" rid="ref2">2</xref>
                </sup>
            </p>
            <p>It was first legalized in the Netherlands. Subsequently, many countries followed suit, including Belgium, Luxembourg, and Canada.
                <sup>
                    <xref ref-type="bibr" rid="ref5">3</xref>
                </sup> In other countries such as the US, euthanasia is legal in some states only under certain conditions. However, it is still illegal in most countries, and there have been instances in India where euthanasia has been permitted by the courts of India.
                <sup>
                    <xref ref-type="bibr" rid="ref4">4</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref14">5</xref>
                </sup> Consider, for example, Shanbaug&#x2019;s case. A nurse, who was assaulted, was left with limited functionality, such as blinking and eating food placed in her mouth.
                <sup>
                    <xref ref-type="bibr" rid="ref3">6</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref7">7</xref>
                </sup> Even after extensive care was provided by the nursing staff of the hospital she remained in, her quality of life was sub-par. The Supreme Court of India permitted euthanasia to be practiced in her case to end the constant suffering her life had become. Similarly, in the case of P. Rathinam Vs. U.O.I, the Supreme Court decided that the right to life, elaborated upon in Article 21 of the Constitution, includes the right to die.
                <sup>
                    <xref ref-type="bibr" rid="ref11">8</xref>
                </sup> In a subsequent case, Gian Kaur Vs. State of Punjab, the court held that the right to die 
                <italic toggle="yes">with dignity</italic> is included in Article 21.
                <sup>
                    <xref ref-type="bibr" rid="ref4">4</xref>
                </sup> Clearly, the Supreme Court of India has made its standpoint- in the case of absolute suffering that cannot be helped, if euthanasia helps alleviate said suffering, it may be done.</p>
            <p>The attitude towards euthanasia has always varied over time. In recent years, there has been an increasing awareness towards the same. Understanding and analyzing the way current and future healthcare providers perceive euthanasia is important, especially in the current world, where debate about legalizing this procedure is ongoing.
                <sup>
                    <xref ref-type="bibr" rid="ref12">9</xref>
                </sup>
            </p>
            <p>This study investigates the attitudes and perceptions of medical students and doctors of a private medical college in Karnataka regarding euthanasia and its legislation in India.</p>
            <sec id="sec6">
                <title>Objectives</title>
                <p>
                    <list list-type="order">
                        <list-item>
                            <label>1.</label>
                            <p>To gauge the awareness of Euthanasia in humans among medical students and doctors,</p>
                        </list-item>
                        <list-item>
                            <label>2.</label>
                            <p>To analyse the attitude and perceptions of medical students and doctors on euthanasia</p>
                        </list-item>
                    </list>
                </p>
            </sec>
        </sec>
        <sec id="sec7" sec-type="methods">
            <title>Methods</title>
            <p>
                <bold>Variables:</bold> Euthanasia is defined as an easy or painless death or the intentional ending of life of a person suffering from an incurable or painful disease at his or her request. This is also called mercy killing.</p>
            <p>
                <bold>Study design:</bold> Cross-sectional study</p>
            <p>
                <bold>Study type:</bold> Analytical study</p>
            <p>
                <bold>Study setting:</bold> Kasturba Medical College, Mangalore</p>
            <p>
                <bold>Study population:</bold> Medical Undergraduates, Interns and Post-Graduates/Doctors of Kasturba Medical College, Mangalore</p>
            <p>
                <bold>Inclusion criteria:</bold> medical undergraduates, interns, and post-graduuates/doctors who gave their consent.</p>
            <p>
                <bold>Study duration:</bold> 10
                <sup>th</sup> March 2022 to 13
                <sup>th</sup> June 2022</p>
            <p>
                <bold>Study sample:</bold> 220. 110 Students and 110 Doctors/PGs/interns.</p>
            <p>
                <bold>Sample size:</bold>
            </p>
            <p>
                <bold>N=Z</bold>
                <sub>
                    <bold>&#x03b1;</bold>
                </sub>
                <sup>
                    <bold>2</bold>
                </sup> 
                <bold>pq/d</bold>
                <sup>
                    <bold>2</bold>
                </sup>
            </p>
            <p>where Z
                <sub>&#x03b1;</sub> = 1.96 for 95% confidence</p>
            <p>p = proportion of the population which has the attribute in question</p>
            <p>q = 1-p</p>
            <p>d = precision</p>
            <p>The sample size was calculated with the help of a study done by Subba et al., titled &#x201c;Doctors&#x2019; Attitude Towards Euthanasia: A Cross-sectional Study,&#x201d; conducted in Mangalore, March-April 2010, which found that while 46.8% of doctors justified euthanasia to alleviate suffering.
                <sup>
                    <xref ref-type="bibr" rid="ref9">10</xref>
                </sup> so considering 46.8% as the prevalence of 46.8% was the prevalence of doctors who justified euthanasia and considering 10% relative precision and 95% confidence, the sample size was calculated to be 200. After adding a 10% non-responsive error, the final sample size was calculated to be 220.</p>
            <p>
                <bold>Sampling strategy:</bold> Convenience sampling (non-probability sampling)</p>
            <p>
                <bold>Tools for data collection:</bold> A questionnaire was prepared after extensive review of the literature. Therefore, a semi-structured questionnaire consists of two sections. Section A consists of two parts: demographic details and awareness. Section B consists of Part 1: ATE Scale and Part 2: Perceptions.</p>
            <p>
                <bold>Scoring and Interpretation:</bold> Here, we used the ATE scale to interpret the attitudes of medical undergraduates, interns, and PGs/doctors towards euthanasia based on the Likert Scale.
                <sup>
                    <xref ref-type="bibr" rid="ref6">11</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref10">12</xref>
                </sup> 1 = strongly disagree, 2 = disagree, 3 = neutral, 4 = agree, and 5 = Strongly Agree.</p>
            <p>
                <bold>Data collection methodology</bold>: The study protocol was approved by the Institutional Ethics Committee (IEC) of Kasturba Medical College, Mangalore. After obtaining approval from the Ethics Committee, permission was obtained from the Dean of Kasturba Medical College, Mangalore, and the data were collected after obtaining informed consent from the participants. All methods were performed in accordance with the relevant guidelines and regulations. The questionnaire was sent to the students in the form of a Google link to WhatsApp, e-mail, and Telegram.</p>
            <p>Online informed consent was obtained from all the participants. Only after consent is given can the Google link for the questionnaire be opened.</p>
            <p>
                <bold>Data analysis:</bold> Data were entered and analyzed using Statistical Software Statistical Package for Social Sciences (SPSS) version 25.0. Descriptive statistics such as mean (standard deviation) and proportion were used to express the results. The various factors associated with attitudes towards euthanasia were analyzed using the chi-square, independent t-test, and linear regression analysis.</p>
            <p>
                <bold>Ethical consideration:</bold> This was a questionnaire-based study of medical undergraduates, interns, and doctors of Kasturba Medical College, Mangalore. The study did not pose any risk to the participants. Interpersonal data will be kept confidential and protected. The records maintained will only be used for research purposes. Entering the research study was voluntary. The participants had the right to stop at any time and did not need to provide any reason for the same.</p>
            <p>
                <bold>Ethical Approval: was taken from the institutional ethics committee of Kasturba Medical College, Mangalore. On 17-03-2022 (DHR Reg. No. EC/NEW/INST/2020/742)</bold>
            </p>
            <p>
                <bold>Consent:</bold> Informed consent was obtained through a Google Form. The initial section of the questionnaire asked participants whether they consented to participate in the study. Those who selected &#x2018;yes&#x2019; were allowed to proceed with the remainder of the questionnaire, while those who selected &#x2018;no&#x2019; were not asked any further questions. This procedure was approved by the ethical committee.</p>
        </sec>
        <sec id="sec8" sec-type="results">
            <title>Results</title>
            <p>Our results indicated that a significant majority (86.3%) were aware of what euthanasia was, although only 47.2% possessed knowledge of the different types of euthanasia, and even fewer (44.3%) were aware of the legalities of its practice in India. Furthermore, only 30.2% of respondents were familiar with the guidelines used to perform euthanasia. Regarding the sources of their information, 29.2% first learned about euthanasia through news, followed by hearsay and work at 25.9%, and personal research at 18.9%. The majority opinion (71.7%) was that the final decision to administer euthanasia should lie with the patient themselves, while 11.8% believed it should be a family member&#x2019;s decision, 9% thought it should be the court of law, and 7.5% placed this responsibility on the treating physician. Regarding the stance on euthanasia, 66% of the respondents were in favor, whereas 34% were against it (
                <xref ref-type="table" rid="T1">Table 1</xref>).</p>
            <table-wrap id="T1" orientation="portrait" position="float">
                <label>Table 1. </label>
                <caption>
                    <title>Distribution of participants based on opinions about various aspects of euthanasia.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1" valign="top">Sl. No.</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Particulars</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Frequency (n)</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Percentage (%)</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">1.</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Awareness of people on Euthanasia</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2022; Aware</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">183</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">86.3</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2022; Not aware</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">29</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">13.7</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">2.</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Knowledge of the types of euthanasia</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2022; Aware</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">100</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">47.2</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2022; Not aware</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">112</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">52.8</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">3.</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Legalities concerning the practice of euthanasia in India</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2022; Aware</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">94</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">44.3</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2022; Not aware</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">118</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">55.7</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">4.</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Awareness of the guidelines that are used to perform euthanasia</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2022; Aware</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">64</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">30.2</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2022; Not aware</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">148</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">69.8</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="5" valign="top">5.</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Source of information about euthanasia for the first time</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2022; Hearsay</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">55</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">25.9</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2022; News</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">62</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">29.2</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2022; Personal research</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">40</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">18.9</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2022; Work</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">55</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">25.9</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="5" valign="top">6.</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Final proxy to administer euthanasia should lie with</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2022; Court of law</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">19</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">9</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2022; Patient themselves</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">152</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">71.7</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2022; Family member</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">25</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">11.8</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2022; Treating physician</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">16</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">7.5</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">7.</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">I am for/against euthanasia</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2022; For</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">140</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">66</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2022; Against</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">72</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">34</td>
                        </tr>
                    </tbody>
                </table>
            </table-wrap>
            <p>A significant majority (86.3%) were aware of what euthanasia was, although only 47.2% possessed knowledge of the different types of euthanasia, and even fewer (44.3%) were aware of the legalities of its practice in India. Furthermore, only 30.2% of respondents were familiar with the guidelines used to perform euthanasia. Regarding the sources of their information, 29.2% first learned about euthanasia through news, followed by hearsay and work at 25.9%, and personal research at 18.9%. The majority opinion (71.7%) was that the final decision to administer euthanasia should lie with the patient themselves, while 11.8% believed it should be a family member&#x2019;s decision, 9% thought it should be the court of law, and 7.5% placed this responsibility on the treating physician. Regarding the stance on euthanasia, 66% of the respondents were in favor, whereas 34% were against it. Among the reasons for supporting the legalization of euthanasia in India, 110 respondents cited relief of suffering, 91 mentioned valuing patient autonomy, 63 highlighted minimizing financial burden, 48 emphasized better utilization of resources, and 20 had other reasons. Reasons for opposing legalization included potential misuse for criminal reasons (38 respondents), the belief that medicine is meant to preserve life (33 respondents), the view that palliative care is sufficient (23 respondents), violation of medical ethics (23 respondents), religious beliefs (8 respondents), and other reasons (8 respondents) (
                <xref ref-type="table" rid="T2">Table 2</xref>).</p>
            <table-wrap id="T2" orientation="portrait" position="float">
                <label>Table 2. </label>
                <caption>
                    <title>Distribution of participants for and against euthanasia based on their justification for their opinion.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1" valign="top">Sl. No.</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Particulars</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Frequency (n)</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="6" valign="top">1.</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Reason for legalisation of euthanasia in India</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2022; Better Utilization of resources</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">48</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2022; Minimise financial burden</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">63</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2022; Patient autonomy is valued</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">91</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2022; To relieve suffering</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">110</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2022; Others</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">20</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="7" valign="top">2.</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Reasons to choose against the legalization of euthanasia in India</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2022; Violation of medical ethics</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">23</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2022; Might be misused for criminal reasons</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">38</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2022; Palliative care is enough</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">23</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2022; Religious beliefs</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">8</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2022; Medicine is to preserve life not end it</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">33</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2022; Others</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">8</td>
                        </tr>
                    </tbody>
                </table>
            </table-wrap>
            <p>On further analysis, the source of acquiring information about euthanasia for the first time has a significant bearing on who the participants feel should be the final proxy for administering euthanasia to patients. Further statistical analysis of the variable regarding the source of euthanasia and attitude towards euthanasia was found to be significant (
                <xref ref-type="table" rid="T3">Table 3</xref>).</p>
            <table-wrap id="T3" orientation="portrait" position="float">
                <label>Table 3. </label>
                <caption>
                    <title>Associations between variables and attitudes toward Euthanasia.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1" valign="top">Variable</th>
                            <th align="left" colspan="1" rowspan="1" valign="top"/>
                            <th align="left" colspan="1" rowspan="1" valign="top">Against</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">For</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Chi-Square</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">P value</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="2" valign="top">Gender</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Female</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">44 (61.1%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">84 (60.0%)</td>
                            <td align="left" colspan="1" rowspan="2" valign="top">0.025</td>
                            <td align="left" colspan="1" rowspan="2" valign="top">0.876</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Male</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">28 (38.9%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">56 (40.0%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="3" valign="top">Age</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">&gt;30 years</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">25 (34.7%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">44 (31.4%)</td>
                            <td align="left" colspan="1" rowspan="3" valign="top">0.363</td>
                            <td colspan="1" rowspan="3"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">18-24 years</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">43 (59.7%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">86 (61.4%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">25-30 years</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4 (5.6%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">10 (7.1%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="5" valign="top">Year of Study</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1
                                <sup>st</sup> year</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (25.0%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">23 (16.4%)</td>
                            <td align="left" colspan="1" rowspan="5" valign="top">3.275</td>
                            <td align="left" colspan="1" rowspan="5" valign="top">0.513</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">2
                                <sup>nd</sup> year</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (25.0%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">42 (30.0%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">3
                                <sup>rd</sup> year</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 (1.4%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4 (2.9%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">4
                                <sup>th</sup> year</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4 (5.6%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">5 (3.6%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Intern/PG/doctor</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">31 (43.1%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">66 (47.1%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="4" valign="top">I heard about Euthanasia for the first time from</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Hearsay</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">9 (12.5%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">46 (32.9%)</td>
                            <td align="left" colspan="1" rowspan="4" valign="top">10.885</td>
                            <td align="left" colspan="1" rowspan="4" valign="top">0.012</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">News</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">26 (36.1%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">36 (25.7%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Personal Research</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">14 (19.4%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">26 (18.6%)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Work</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">23 (31.9%)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">32 (22.9%)</td>
                        </tr>
                    </tbody>
                </table>
            </table-wrap>
            <p>We can infer that respondents&#x2019; opinions on the legalization of euthanasia in India are highly influenced by the source of acquiring information about euthanasia for the first time, and this was found to be statistically significant (
                <xref ref-type="table" rid="T4">Table 4</xref>).</p>
            <table-wrap id="T4" orientation="portrait" position="float">
                <label>Table 4. </label>
                <caption>
                    <title>Association between the source where the participants first heard about euthanasia and who they feel should be the final proxy of euthanasia.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1" valign="top">I feel the final proxy of the patient should be</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Hearsay</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">News</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Personal research</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Work</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Chi square value</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">P value</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Court of law</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">1</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">7</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">2</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">9</td>
                            <td align="left" colspan="1" rowspan="4" valign="middle">22.303</td>
                            <td align="left" colspan="1" rowspan="4" valign="middle">.008</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Euthanasia should only be done with the explicit consent and will of the patient</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">51</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">43</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">26</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">32</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Family member</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">3</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">7</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">7</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">8</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Treating physician</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">5</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">5</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">6</td>
                        </tr>
                    </tbody>
                </table>
            </table-wrap>
        </sec>
        <sec id="sec9" sec-type="discussion">
            <title>Discussion</title>
            <p>This study analyzed the attitudes and perceptions of healthcare workers towards Euthanasia. The present study was conducted at Kasturba Medical College, Mangalore. The composition of the study participants varied and ranged from doctors, post-graduates, interns, to medical students, although there were more medical students and interns than doctors and post-graduates. The participants were restricted to the students and staff of Kasturba Medical College, Mangalore. Statistical Package for the Social Sciences (SPSS) was used to analyze the data.</p>
            <p>In the present study, 86.3% of the respondents were aware of the concept of euthanasia. Similar results were obtained in a study conducted in 2013, wherein the majority of selected professionals in New Delhi were aware of the concept of euthanasia.
                <sup>
                    <xref ref-type="bibr" rid="ref7">7</xref>
                </sup>
            </p>
            <p>In this study, it was found that the majority of respondents who first encountered euthanasia via news or hearsay were of the opinion that euthanasia should only be practiced with the explicit consent of the patient. 66 Of the respondents, 66% were euthanized, and 34% were against it. Moreover, the majority of people who stood for euthanasia also first encountered euthanasia via news or hearsay. Thus, this study suggests that society and mass media heavily influence controversial topics, such as euthanasia. A systematic review of studies conducted in the UK to assess the attitudes of doctors towards euthanasia was conducted in 2012. This review revealed that the doctors mostly opposed the introduction of physician-assisted suicide (PAS) and Active Voluntary Euthanasia (AVE). Religious reasons were part of why doctors opposed euthanasia.
                <sup>
                    <xref ref-type="bibr" rid="ref9">10</xref>
                </sup> The present study showed majority of the people who were for euthanasia gave the reason &#x201c;To relieve suffering.&#x201d; A similar cross-sectional study was conducted in South India in 2011 to assess the attitudes of doctors towards euthanasia, wherein a majority of the respondents (69.3%) supported the concept of euthanasia, giving &#x201c;relief from unbearable pain and suffering&#x201d; as the most cited reason for the same.
                <sup>
                    <xref ref-type="bibr" rid="ref8">13</xref>
                </sup> Another study conducted in Sri Lanka in 2021 to analyze attitudes toward euthanasia among medical students showed that 47.1% of the participants favored legalizing euthanasia, whereas 25.9% directly opposed it. 27% were undecided. Participants who came under the undecided category were more likely to have unfavorable ATE.
                <sup>
                    <xref ref-type="bibr" rid="ref6">11</xref>
                </sup>
            </p>
            <p>Thus, several studies have shown how the attitudes and perceptions of euthanasia vary among medical practitioners.</p>
            <p>In conclusion, the attitudes and perceptions of medical practitioners towards euthanasia are varied and heavily influenced by how euthanasia is portrayed in mass media. There has been a gradual shift in people&#x2019;s general opinions that seem to favor euthanasia, but concerns about its misuse continue to remain.</p>
            <p>This study was conducted to analyze the attitudes and perceptions of healthcare practitioners towards euthanasia, and has effectively shown how the opinions and views of people shift due to mass media, society, and personal beliefs.</p>
            <p>It is important to consider the thoughts of medical professionals towards euthanasia - those who work closely with patients - to analyze and understand the highly subjective topic of whether life must be qualitatively viewed or quantitatively.</p>
        </sec>
        <sec id="sec10" sec-type="conclusion">
            <title>Conclusion</title>
            <p>In conclusion, euthanasia has been a topic of much debate since the ages and is still illegal in India; however, there is a change in the opinions of people, especially physicians and future caregivers, as is also evident in this study. Physicians&#x2019; views on this topic are also influenced by a multitude of factors such as where they first came to know about euthanasia.</p>
            <p>In this study, we found that the majority of the respondents who first came across euthanasia via news or hearsay were of the opinion that euthanasia should only be practiced with the explicit consent of the patient.
                <sup>
                    <xref ref-type="bibr" rid="ref13">14</xref>
                </sup> Furthermore majority of the people who stand for euthanasia as a practice also first encountered euthanasia via news or hearsay.</p>
            <p>It would therefore appear that when it comes to such sensitive issues as euthanasia, the people&#x2019;s opinions are influenced by the society they live in and how euthanasia is being portrayed in that society by means of mass media such as stories, news, articles, television, etc. There is indeed an evident shift in people&#x2019;s opinions about euthanasia, since the majority of the respondents supported euthanasia and its legalization in this study. However, there are still lingering concerns regarding their possible misuse.</p>
            <sec id="sec15">
                <title>Ethics and consent</title>
                <p>The study protocol was approved by the Institutional Ethics Committee (IEC) of Kasturba Medical College, Mangalore. After obtaining approval from the Ethics Committee, permission was obtained from the Dean of Kasturba Medical College, Mangalore, and the data were collected after obtaining informed consent from the participants.</p>
            </sec>
        </sec>
    </body>
    <back>
        <sec id="sec13" sec-type="data-availability">
            <title>Data availability</title>
            <sec id="sec14">
                <title>Underlying data</title>
                <p>Figshare: Perceptions and Attitudes of Medical Students and Doctors on Euthanasia, 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.6084/m9.figshare.26200124.v2">https://doi.org/10.6084/m9.figshare.26200124.v2</ext-link>.
                    <sup>

                        <xref ref-type="bibr" rid="ref16">15</xref>
</sup>
                </p>
                <p>This project contains the following underlying data:
                    <list list-type="order">
                        <list-item>
                            <label>1.</label>
                            <p>Data</p>
                        </list-item>
                    </list>
                </p>
                <p>Data are available under the terms of the 
                    <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International license</ext-link> (CC-BY 4.0).</p>
            </sec>
            <sec id="sec16">
                <title>Extended data</title>
                <p>Figshare: Perceptions and Attitudes of Medical Students and Doctors on Euthanasia. 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.6084/m9.figshare.26501110.v2">https://doi.org/10.6084/m9.figshare.26501110.v2</ext-link>

                    <sup>

                        <xref ref-type="bibr" rid="ref15">16</xref>
</sup>
                </p>
                <p>This project contains the following underlying data:
                    <list list-type="order">
                        <list-item>
                            <label>1.</label>
                            <p>

                                <ext-link ext-link-type="uri" xlink:href="https://figshare.com/account/projects/212315/articles/26501110">Questionnaire - Perceptions and Attitudes of Medical Students and Doctors on Euthanasia</ext-link>
                            </p>
                        </list-item>
                    </list>
                </p>
                <p>Data are available under the terms of the 
                    <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International license</ext-link> (CC-BY 4.0).</p>
            </sec>
        </sec>
        <ref-list>
            <title>References</title>
            <ref id="ref1">
                <label>1</label>
                <mixed-citation publication-type="book">
                    <source>

                        <italic toggle="yes">NCI dictionary of Cancer Terms.</italic>
</source>
                    <publisher-name>National Cancer Institute</publisher-name>;<year>2011 [cited 2022 Jul3]</year>.
                    <ext-link ext-link-type="uri" xlink:href="https://www.cancer.gov/publications/dictionaries/cancer-terms/def/euthanasia">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref2">
                <label>2</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Sinha</surname>
                            <given-names>VK</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Basu</surname>
                            <given-names>S</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Sarkhel</surname>
                            <given-names>S</given-names>
                        </name>
</person-group>:
                    <article-title>Euthanasia: An Indian perspective.</article-title>
                    <source>

                        <italic toggle="yes">Indian J. Psychiatry.</italic>
</source>
                    <year>2012 Apr</year>;<volume>54</volume>(<issue>2</issue>):<fpage>177</fpage>&#x2013;<lpage>183</lpage>.
                    <pub-id pub-id-type="pmid">22988327</pub-id>
                    <pub-id pub-id-type="doi">10.4103/0019-5545.99537</pub-id>
                    <pub-id pub-id-type="pmcid">PMC3440914</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref5">
                <label>3</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Patil</surname>
                            <given-names>YD</given-names>
                        </name>
</person-group>:
                    <article-title>Euthanasia and Death with Dignity.</article-title>
                    <source>

                        <italic toggle="yes">JKIMSU.</italic>
</source>
                    <year>2016 Jul-Sep</year>;<volume>5</volume>(<issue>3</issue>):<fpage>142</fpage>&#x2013;<lpage>144</lpage>.
                    <ext-link ext-link-type="uri" xlink:href="http://jkimsu.com/jkimsuvol5no3/JKIMSU,%20Vol.%205,%20No.%203,%20July-Sept%202016%20Page%20142-144.pdf">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref4">
                <label>4</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Mudur</surname>
                            <given-names>G</given-names>
                        </name>
</person-group>:
                    <article-title>Indian court says it may sanction euthanasia in the future.</article-title>
                    <source>

                        <italic toggle="yes">BMJ.</italic>
</source>
                    <year>2011 [cited 2022 Jul 3]</year>;<volume>342</volume>(<issue>mar11 2</issue>):<fpage>d1628</fpage>.
                    <pub-id pub-id-type="pmid">21398360</pub-id>
                    <pub-id pub-id-type="doi">10.1136/bmj.d1628</pub-id>
                    <ext-link ext-link-type="uri" xlink:href="https://www.bmj.com/content/342/bmj.d1628.extract">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref14">
                <label>5</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Kranidiotis</surname>
                            <given-names>G</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Ropa</surname>
                            <given-names>J</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Mprianas</surname>
                            <given-names>J</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Attitudes towards euthanasia among Greek intensive care unit physicians and nurses.</article-title>
                    <source>

                        <italic toggle="yes">Heart Lung.</italic>
</source>
                    <year>2015</year>;<volume>44</volume>(<issue>3</issue>):<fpage>260</fpage>&#x2013;<lpage>263</lpage>.
                    <pub-id pub-id-type="pmid">25840865</pub-id>
                    <pub-id pub-id-type="doi">10.1016/j.hrtlng.2015.03.001</pub-id>
                    <ext-link ext-link-type="uri" xlink:href="https://www.sciencedirect.com/science/article/pii/S014795631500062X">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref3">
                <label>6</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Singh</surname>
                            <given-names>N</given-names>
                        </name>
</person-group>:
                    <article-title>India is now among select group of nations where passive euthanasia is legal.</article-title>
                    <source>

                        <italic toggle="yes">ThePrint.</italic>
</source>
                    <year>2018 [cited 2022 Jul 3]</year>.
                    <ext-link ext-link-type="uri" xlink:href="https://theprint.in/theprint-essential/india-is-among-group-nations-passive-euthanasia-legal/40421">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref7">
                <label>7</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Kamath</surname>
                            <given-names>S</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Bhate</surname>
                            <given-names>P</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Mathew</surname>
                            <given-names>G</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Attitudes Toward Euthanasia Among Doctors in a Tertiary Care Hospital in South India: A Cross Sectional study.</article-title>
                    <source>

                        <italic toggle="yes">Indian J. Palliat. Care.</italic>
</source>
                    <year>2011 Sep [cited 2023 Mar 31]</year>;<volume>17</volume>(<issue>3</issue>):<fpage>197</fpage>&#x2013;<lpage>201</lpage>.
                    <pub-id pub-id-type="pmid">22346044</pub-id>
                    <pub-id pub-id-type="doi">10.4103/0973-1075.92336</pub-id>
                    <pub-id pub-id-type="pmcid">PMC3276816</pub-id>
                    <ext-link ext-link-type="uri" xlink:href="https://pubmed.ncbi.nlm.nih.gov/22346044/">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref11">
                <label>8</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Bandewar</surname>
                            <given-names>SV</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Chaudhuri</surname>
                            <given-names>L</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Duggal</surname>
                            <given-names>L</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>The Supreme Court of India on euthanasia: Too little, too late.</article-title>
                    <source>

                        <italic toggle="yes">Indian J Med Ethics.</italic>
</source>
                    <year>2018 Apr-Jun</year>;<volume>3</volume>(<issue>2</issue>):<fpage>91</fpage>&#x2013;<lpage>94</lpage>.
                    <pub-id pub-id-type="pmid">29724694</pub-id>
                    <pub-id pub-id-type="doi">10.20529/IJME.2018.028</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref12">
                <label>9</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Mani</surname>
                            <given-names>RK</given-names>
                        </name>
</person-group>:
                    <article-title>Constitutional and Legal Protection for Life Support Limitation in India.</article-title>
                    <source>

                        <italic toggle="yes">Indian J. Palliat. Care.</italic>
</source>
                    <year>2015 Sep-Dec</year>;<volume>21</volume>(<issue>3</issue>):<fpage>258</fpage>&#x2013;<lpage>261</lpage>.
                    <pub-id pub-id-type="pmid">26600691</pub-id>
                    <pub-id pub-id-type="doi">10.4103/0973-1075.164903</pub-id>
                    <pub-id pub-id-type="pmcid">PMC4617030</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref9">
                <label>10</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Subba</surname>
                            <given-names>SH</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Khullar</surname>
                            <given-names>V</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Latafat</surname>
                            <given-names>Y</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Doctors&#x2019; Attitude Towards Euthanasia: A Cross-sectional Study Experience.</article-title>
                    <source>

                        <italic toggle="yes">Japi.</italic>
</source>
                    <year>2016</year>;<fpage>63</fpage>.
                    <ext-link ext-link-type="uri" xlink:href="https://www.japi.org/r284c454/doctorss-attitude-towards-euthanasia-a-cross-sectional-study-experience">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref6">
                <label>11</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Herath</surname>
                            <given-names>HMMTB</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Wijayawardhana</surname>
                            <given-names>KWSM</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Wickramarachchi</surname>
                            <given-names>UI</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Attitudes on euthanasia among medical students and doctors in Sri Lanka: a cross sectional study.</article-title>
                    <source>

                        <italic toggle="yes">BMC Med. Ethics.</italic>
</source>
                    <year>2021 Dec 7</year>;<volume>22</volume>(<issue>1</issue>):<fpage>162</fpage>.
                    <pub-id pub-id-type="pmid">34876119</pub-id>
                    <pub-id pub-id-type="doi">10.1186/s12910-021-00731-2</pub-id>
                    <pub-id pub-id-type="pmcid">PMC8650524</pub-id>
                    <ext-link ext-link-type="uri" xlink:href="https://pubmed.ncbi.nlm.nih.gov/34876119/">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref10">
                <label>12</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Wasserman</surname>
                            <given-names>J</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Clair</surname>
                            <given-names>JM</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Ritchey</surname>
                            <given-names>FJ</given-names>
                        </name>
</person-group>:
                    <article-title>A scale to assess attitudes toward euthanasia.</article-title>
                    <source>

                        <italic toggle="yes">Omega (Westport).</italic>
</source>
                    <year>2005</year>;<volume>51</volume>(<issue>3</issue>):<fpage>229</fpage>&#x2013;<lpage>237</lpage>.
                    <pub-id pub-id-type="pmid">16459436</pub-id>
                    <pub-id pub-id-type="doi">10.2190/FGHE-YXHX-QJEA-MTM0</pub-id>
                    <ext-link ext-link-type="uri" xlink:href="https://pubmed.ncbi.nlm.nih.gov/16459436/">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref8">
                <label>13</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>McCormack</surname>
                            <given-names>R</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Clifford</surname>
                            <given-names>M</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Conroy</surname>
                            <given-names>M</given-names>
                        </name>
</person-group>:
                    <article-title>Attitudes of UK doctors towards euthanasia and physician-assisted suicide: a systematic literature review.</article-title>
                    <source>

                        <italic toggle="yes">Palliat. Med.</italic>
</source>
                    <year>2012 Jan</year>;<volume>26</volume>(<issue>1</issue>):<fpage>23</fpage>&#x2013;<lpage>33</lpage>. Erratum in: Palliat Med. 2012 Jul;26(5):770.
                    <pub-id pub-id-type="pmid">22190615</pub-id>
                    <pub-id pub-id-type="doi">10.1177/0269216310397688</pub-id>
                    <ext-link ext-link-type="uri" xlink:href="https://pubmed.ncbi.nlm.nih.gov/22190615/">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref13">
                <label>14</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Dees</surname>
                            <given-names>MK</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Vernooij-Dassen</surname>
                            <given-names>MJ</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Dekkers</surname>
                            <given-names>WJ</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Perspectives of decision-making in requests for euthanasia: a qualitative research among patients, relatives and treating physicians in the Netherlands.</article-title>
                    <source>

                        <italic toggle="yes">Palliat. Med.</italic>
</source>
                    <year>2013</year>;<volume>27</volume>(<issue>1</issue>):<fpage>27</fpage>&#x2013;<lpage>37</lpage>.
                    <pub-id pub-id-type="pmid">23104511</pub-id>
                    <pub-id pub-id-type="doi">10.1177/0269216312463259</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref16">
                <label>15</label>
                <mixed-citation publication-type="other">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Mallya</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Motappa</surname>
                            <given-names>R</given-names>
                        </name>
</person-group>:
                    <article-title>Data - Perceptions and Attitudes of Medical Students and Doctors on Euthanasia.xlsx.</article-title>
                    <source>

                        <italic toggle="yes">figshare.</italic>
</source>
                    <year>2024 [cited 2024Aug20]</year>.
                    <ext-link ext-link-type="uri" xlink:href="https://figshare.com/articles/dataset/Data_-_Perceptions_and_Attitudes_of_Medical_Students_and_Doctors_on_Euthanasia_xlsx/26200124/1">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref15">
                <label>16</label>
                <mixed-citation publication-type="other">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Mallya</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Motappa</surname>
                            <given-names>R</given-names>
                        </name>
</person-group>:
                    <article-title>Questionnaire - Perceptions and Attitudes of Medical Students and Doctors on Euthanasia.</article-title>
                    <source>

                        <italic toggle="yes">figshare.</italic>
</source>
                    <year>2024 [cited 2024Aug20]</year>.
                    <ext-link ext-link-type="uri" xlink:href="https://figshare.com/articles/online_resource/Questionnaire_-_Perceptions_and_Attitudes_of_Medical_Students_and_Doctors_on_Euthanasia/26501110/1">Reference Source</ext-link>
                </mixed-citation>
            </ref>
        </ref-list>
    </back>
    <sub-article article-type="reviewer-report" id="report363347">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.168923.r363347</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Buterin</surname>
                        <given-names>Toni</given-names>
                    </name>
                    <xref ref-type="aff" rid="r363347a1">1</xref>
                    <xref ref-type="aff" rid="r363347a1">1</xref>
                    <role>Referee</role>
                </contrib>
                <aff id="r363347a1">
                    <label>1</label>University of Rijeka, Rijeka, Croatia</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>19</day>
                <month>2</month>
                <year>2025</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2025 Buterin T</copyright-statement>
                <copyright-year>2025</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport363347" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.153956.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>reject</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>
                <bold>The</bold> 
                <bold>introduction</bold> of the paper effectively introduces the topic of euthanasia, but it contains several weaknesses that reduce its clarity and precision. In such a complex research field, euthanasia should not be narrowed to a classical definition, but instead, it should be expanded and argued as it goes beyond the scope of (only) medicine. Euthanasia involves perspectives from various fields such as philosophy, sociology, law, and theology. Before focusing on India, the introduction should provide a broader overview of global trends in the regulation (and attitudes) toward euthanasia. Many countries adopt varying approaches, from full legalization to strict prohibition, depending on the type and with different exceptions under different conditions. Understanding these variations is crucial for comparison with the Indian legal framework and the consequential attitudes &#x2013; in this case, of doctors and medical students. The introduction would be clearer and stronger if the global perspective were analyzed first, followed by a more detailed discussion of the Indian case. More precise formulations and better arguments would improve the quality of the paper.</p>
            <p> 
                <bold>The objectives</bold> need to be formulated more precisely to be clearer and more strongly justified. The current formulations are incomplete and unclear. This is especially evident when reading the conclusion, where it is difficult to determine if the research objectives have been achieved.</p>
            <p> 
                <bold>The methodology</bold> requires a more detailed description. The aim and purpose of the research are unclear. The limitations of the study need to be highlighted, as the choice of participants could lead to bias and limit the representativeness of the population. Participants are from one 'pool' (Kasturba Medical College), which means the results may not be applicable to the broader population of (future) medical professionals in India.</p>
            <p> 
                <bold>The results</bold> are brief and need to be expanded. The first two paragraphs are duplicated. In Table 2, it is unclear how the total sample can exceed 100% for female respondents (61.1% for, 60% against). For male respondents, the total is less than 100% (38.9% for, 40% against). Is this an error, or am I misinterpreting it?</p>
            <p> In 
                <bold>the discussion</bold>, it is highlighted that attitudes towards euthanasia are highly diverse, but there is a lack of detailed discussion about contradictions within the results themselves (a lot of the content repeats again), as well as the influence of specific sociocultural factors in the context of India and possible causes. Additionally, the potential bias of the sample is not considered, given that the sample is limited to a single medical school. The discussion deviates from the standard academic approach. A more detailed analysis of the causes and broader implications of respondents' attitudes toward euthanasia is needed, with more concrete references to existing works, stronger argumentation, and the presentation of facts derived from research on similar topics. The discussion should also address methods for reducing bias in future research. There is no analysis of trends or a more specific comparison with previous studies.</p>
            <p> 
                <bold>The conclusion</bold> is based more on speculation than on the real outcomes of the objectives. In fact, it is unclear from the conclusion whether the stated objectives have been justified. The focus has shifted from assessing awareness and analyzing the attitudes of doctors and students to the influence of the media. How the media (and the way euthanasia is reported) succeeded in steering respondents toward positive attitudes and a significant correlation remains an open question. Since the role of the media in shaping views is already addressed in the discussion and conclusion, it should have been introduced earlier, particularly in relation to its influence on reporting contemporary medico-ethical controversial issues.</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Partly</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>I cannot comment. A qualified statistician is required.</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Partly</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Partly</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>No</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Reviewer Expertise:</p>
            <p>Medical ethics, Bioethics, Public health, History of Medicine</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above.</p>
        </body>
        <sub-article article-type="response" id="comment14299-363347">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Mallya</surname>
                            <given-names>Ajay</given-names>
                        </name>
                        <aff>Community Medicine, Kasturba Medical College, Mangalore, karnataka, India</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>31</day>
                    <month>7</month>
                    <year>2025</year>
                </pub-date>
            </front-stub>
            <body>
                <p>Dear Reviewer</p>
                <p> </p>
                <p> Thank you for your insightful feedback. We&#x2019;ve revised the manuscript to address your comments, improving clarity.</p>
            </body>
        </sub-article>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report360955">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.168923.r360955</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Pic&#x00f3;n Jaimes</surname>
                        <given-names>Yelson Alejandro</given-names>
                    </name>
                    <xref ref-type="aff" rid="r360955a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-7498-5346</uri>
                </contrib>
                <aff id="r360955a1">
                    <label>1</label>Univ Ramon Llul, Barcelona, Spain</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>29</day>
                <month>1</month>
                <year>2025</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2025 Pic&#x00f3;n Jaimes YA</copyright-statement>
                <copyright-year>2025</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport360955" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.153956.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>reject</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>
                <bold>Introduction</bold>
            </p>
            <p> The definition of euthanasia is generally correct, but it could be made more precise by clearly differentiating between active euthanasia, assisted suicide, passive euthanasia, dysthanasia, and orthothanasia. As it stands, the current definition blends technical and common terms, which may lead to confusion.</p>
            <p> </p>
            <p> To enhance global context, more specific data should be included, such as:</p>
            <p> </p>
            <p> In the Netherlands, euthanasia was legalised in 2002 under strict criteria.</p>
            <p> Canada legalised it in 2016 under the term "Medical Assistance in Dying" (MAiD).</p>
            <p> Providing such details adds precision and context to the information.</p>
            <p> </p>
            <p> Additionally, it would be useful to explain how the Gian Kaur judgment laid the foundation for recognising the "right to die with dignity" within the framework of Article 21 of the Indian Constitution. However, it is essential to clarify that this right does not extend to assisted suicide.</p>
            <p> </p>
            <p> 
                <bold>Methods</bold>
            </p>
            <p> Definition of Euthanasia in Variables:</p>
            <p> The definition of euthanasia in the "Variables" section is repetitive (already mentioned in the introduction) and overly general for the methods section.</p>
            <p> </p>
            <p> 
                <bold>Study Design:</bold>
            </p>
            <p> The study is referred to as both cross-sectional and analytical, which creates confusion. If the study is cross-sectional, it is typically descriptive rather than analytical. This should be clarified.</p>
            <p> </p>
            <p> The word "post-graduuates" in the inclusion criteria contains a typographical error.</p>
            <p> </p>
            <p> 
                <bold>Sampling Justification:</bold>
            </p>
            <p> The use of convenience sampling should be justified, and its limitations acknowledged. For example:</p>
            <p> </p>
            <p> "Convenience sampling was employed due to the accessibility of participants in an academic setting. While this method may introduce biases, it was suitable for an exploratory, single-centre study."</p>
            <p> Additionally, if convenience sampling was used (a non-probabilistic method), it should be clarified why a probabilistic sample size calculation was performed.</p>
            <p> </p>
            <p> 
                <bold>Description of the Questionnaire:</bold>
            </p>
            <p> The description of the data collection tool (questionnaire) is too short. It does not specify how the questionnaire was validated or whether a pilot study was conducted before its implementation.</p>
            <p> </p>
            <p> 
                <bold>Data Analysis:</bold>
            </p>
            <p> The data analysis section is too brief and lacks clarity on the dependent and independent variables. It should also specify the measures of central tendency (e.g., mean, median) and dispersion (e.g., standard deviation) used. Moreover, it should detail which statistical tests were employed to examine associations (e.g., chi-square, t-tests).</p>
            <p> </p>
            <p> 
                <bold>Ethical Considerations:</bold>
            </p>
            <p> The ethical considerations section should explain the data protection measures implemented, particularly since the questionnaires were administered virtually. For instance:</p>
            <p> </p>
            <p> "All virtual questionnaires were anonymised, and responses were securely stored to ensure data confidentiality. Access to the data was restricted to authorised personnel only."</p>
            <p> </p>
            <p> 
                <bold>Results</bold>
            </p>
            <p> </p>
            <p> The first and second paragraphs of the results section are redundant and repeat the same ideas. This should be streamlined for clarity.</p>
            <p> </p>
            <p> The results are purely descriptive, which is inconsistent with the stated study design of an "analytical study." This discrepancy reinforces the idea that the study is descriptive rather than analytical.</p>
            <p> </p>
            <p> The results do not adequately address the second study objective: "To analyse the attitude and perceptions of medical students and doctors on euthanasia." A more focused analysis is needed to examine attitudes and perceptions. Statistical tests (e.g., chi-square or regression analysis) could be employed to identify significant factors influencing attitudes.</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Partly</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Partly</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Partly</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Partly</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Partly</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>No</p>
            <p>Reviewer Expertise:</p>
            <p>Clinical and applied bioethics in the experimental field. Research methodology. Epidemiology and public health</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above.</p>
        </body>
        <sub-article article-type="response" id="comment14298-360955">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Mallya</surname>
                            <given-names>Ajay</given-names>
                        </name>
                        <aff>Community Medicine, Kasturba Medical College, Mangalore, karnataka, India</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>31</day>
                    <month>7</month>
                    <year>2025</year>
                </pub-date>
            </front-stub>
            <body>
                <p>Dear Reviewer</p>
                <p> </p>
                <p> Thank you for your insightful feedback. We&#x2019;ve revised the manuscript to address your comments, improving clarity.</p>
            </body>
        </sub-article>
    </sub-article>
</article>
