<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN" "http://jats.nlm.nih.gov/publishing/1.2/JATS-journalpublishing1.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="research-article" dtd-version="1.2" xml:lang="en">
    <front>
        <journal-meta>
            <journal-id journal-id-type="pmc">F1000Research</journal-id>
            <journal-title-group>
                <journal-title>F1000Research</journal-title>
            </journal-title-group>
            <issn pub-type="epub">2046-1402</issn>
            <publisher>
                <publisher-name>F1000 Research Limited</publisher-name>
                <publisher-loc>London, UK</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="doi">10.12688/f1000research.159550.1</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Research Article</subject>
                </subj-group>
                <subj-group>
                    <subject>Articles</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Is publishing gold open-access worth it? An assessment of hybrid and gold open-access publishing models of medical journals on their impact</article-title>
                <fn-group content-type="pub-status">
                    <fn>
                        <p>[version 1; peer review: 2 not approved]</p>
                    </fn>
                </fn-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author" corresp="yes">
                    <name>
                        <surname>Thabit</surname>
                        <given-names>Abrar K.</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-0369-9094</uri>
                    <xref ref-type="corresp" rid="c1">a</xref>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Ashy</surname>
                        <given-names>Noha I.</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Fallatah</surname>
                        <given-names>Abdulrahman O.</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <xref ref-type="aff" rid="a2">2</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Alquzi</surname>
                        <given-names>Ali S.</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <xref ref-type="aff" rid="a2">2</xref>
                </contrib>
                <aff id="a1">
                    <label>1</label>Pharmacy Practice Department, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia</aff>
                <aff id="a2">
                    <label>2</label>Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia</aff>
            </contrib-group>
            <author-notes>
                <corresp id="c1">
                    <label>a</label>
                    <email xlink:href="mailto:akthabit@kau.edu.sa">akthabit@kau.edu.sa</email>
                </corresp>
                <fn fn-type="conflict">
                    <p>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>9</day>
                <month>12</month>
                <year>2024</year>
            </pub-date>
            <pub-date pub-type="collection">
                <year>2024</year>
            </pub-date>
            <volume>13</volume>
            <elocation-id>1502</elocation-id>
            <history>
                <date date-type="accepted">
                    <day>2</day>
                    <month>12</month>
                    <year>2024</year>
                </date>
            </history>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2024 Thabit AK et al.</copyright-statement>
                <copyright-year>2024</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <self-uri content-type="pdf" xlink:href="https://f1000research.com/articles/13-1502/pdf"/>
            <abstract>
                <sec>
                    <title>Background</title>
                    <p>Hybrid and gold open-access (OA) are the most common publishing models. The latter requires fees to allow full-text visibility upon publishing, whereas hybrid journals offer the option to publish gold OA or for free (subscription-based) where only users with access can get the full-text. We aimed to evaluate the impact of the publishing model and other factors on medical journals&#x2019; impact.</p>
                </sec>
                <sec>
                    <title>Methods</title>
                    <p>A sample of hybrid and gold OA medical journals indexed in Web of Science (WOS) and Scopus were included. The effect of the publishing model and other factors on journals&#x2019; impact factor (IF), CiteScore, quartile, and number of citations was assessed.</p>
                </sec>
                <sec>
                    <title>Results</title>
                    <p>402 journals were included, 201 in each group. Hybrid and gold OA journals had a median age of 32 and 21 years, respectively (
                        <italic toggle="yes">P</italic>&lt;0.001). The median publishing cost in gold OA journals was $2,690, and 46.3% of them publish continuously. Publishing model, journal&#x2019;s age, being of an organization/society, and EMBASE indexation didn&#x2019;t affect IF, CiteScore, number of citations, and WOS quartile (
                        <italic toggle="yes">P</italic>&gt;0.05). However, gold OA model wasn&#x2019;t significantly associated with Q1 ranking in Scopus (OR, 0.49; 95% CI, 0.25-0.94; 
                        <italic toggle="yes">P</italic>=0.032), which indicates that hybrid journals were more likely to have such ranking.</p>
                </sec>
                <sec>
                    <title>Conclusion</title>
                    <p>These findings indicate that gold OA publishing doesn&#x2019;t necessarily result in higher impact, which contradicts the claim that such model enhances citations. Therefore, authors can continue to publish in hybrid journals without being concerned about getting cited. Gold OA journals are encouraged to reduce their fees to facilitate global research access.</p>
                </sec>
            </abstract>
            <kwd-group kwd-group-type="author">
                <kwd>publishing</kwd>
                <kwd>hybrid</kwd>
                <kwd>open-access</kwd>
                <kwd>publisher</kwd>
                <kwd>journal</kwd>
                <kwd>journal impact factor</kwd>
            </kwd-group>
            <funding-group>
                <funding-statement>The author(s) declared that no grants were involved in supporting this work.</funding-statement>
            </funding-group>
        </article-meta>
    </front>
    <body>
        <sec id="sec5" sec-type="intro">
            <title>Introduction</title>
            <p>Open access (OA) publications allow individuals to read published scientific articles for free, regardless of location, institutional affiliation, or subscription to the journal (or its publisher).
                <sup>
                    <xref ref-type="bibr" rid="ref1">1</xref>
                </sup> Currently, OA publishing model includes several subtypes, the most common type is gold OA, where authors retain the copyright to their published article that is made freely available to any user in the online journal.
                <sup>
                    <xref ref-type="bibr" rid="ref2">2</xref>
                </sup> Gold OA publishing model requires the payment of a certain fee by the authors. The other type of OA publishing model is green open access, which permits the placement of the authors&#x2019; manuscript in an institutional repository and then the article becomes freely available after an embargo period set by the journal. Green OA journals usually ask for page charges, in which the total is usually lower than gold OA charges. The concept of gold OA publishing was recently adapted within the last 20 years as journals used to be subscription-based only (i.e., access to articles are only allowed to users subscribed to the journal via their institution or a personal subscription while authors publish their work without a fee).
                <sup>
                    <xref ref-type="bibr" rid="ref3">3</xref>
                </sup> However, upon the introduction of gold OA concept, it became widespread among publishers as numerus journals became hybrid, meaning that they allow both subscription-based publishing for authors opting to publish for free and gold OA publishing for authors willing to pay the publication fees. OA publishing is becoming more popular as large research funding agencies, such as the National Institutes of Health in the United States and the Bill and Melinda Gates Foundation, require researchers to make their work freely available.
                <sup>
                    <xref ref-type="bibr" rid="ref2">2</xref>,
                    <xref ref-type="bibr" rid="ref4">4</xref>
                </sup>
            </p>
            <p>Access to medical literature is an essential part of healthcare professionals&#x2019; job to make decisions regarding disease management and implementation of certain interventions. Instead of attempting to base their decisions simply on the subset of research to which they have access, clinicians can make more informed health decisions when they have entire access to studies relevant to the cases they are treating.
                <sup>
                    <xref ref-type="bibr" rid="ref5">5</xref>
                </sup> OA articles are more frequently read, and hence promote access to knowledge and new advances in different disciplines. Since the early 1990s, there has been a notable surge in OA publication, with an estimated annual growth in published articles of 30%.
                <sup>
                    <xref ref-type="bibr" rid="ref6">6</xref>
                </sup> Furthermore, a number of universities and journal publishers have recently signed Open Access Transformative Agreements (OATAs), which require a greater transition to OA article publication over a predetermined time period, in response to recommendations from the research communities, such as the Efficiency and Standards for Article Charges Initiative.
                <sup>
                    <xref ref-type="bibr" rid="ref7">7</xref>
                </sup>
            </p>
            <p>Despite the advantages of OA publishing, it has a major disadvantage that should be acknowledged. To publish an OA article, journals ask the publishing fees, which are commonly known as article processing charges (APCs). These charges, which sometimes reach thousands of US dollars, may prevent authors with limited institutional or personal funds from publishing openly.
                <sup>
                    <xref ref-type="bibr" rid="ref8">8</xref>,
                    <xref ref-type="bibr" rid="ref9">9</xref>
                </sup> The unaffordability of APCs may create a barrier to sharing research.
                <sup>
                    <xref ref-type="bibr" rid="ref10">10</xref>
                </sup> Such major issue influenced many researchers to call for free access to research without barriers (i.e., the need for subscription or forcing authors to pay APCs to make their research accessible to all.
                <sup>
                    <xref ref-type="bibr" rid="ref11">11</xref>
                </sup>
            </p>
            <p>The prevailing view suggests that the advent of OA publishing model enhances the spread of knowledge and potentially increases citation counts for authors; though, this continues to be contested. Therefore, the objective of this study is to evaluate the effect of the gold OA publishing model on several journals&#x2019; metrics on Web of Science (WOS) and Scopus by comparing it to hybrid publishing model.</p>
        </sec>
        <sec id="sec6" sec-type="methods">
            <title>Methods</title>
            <sec id="sec7">
                <title>Journals selection</title>
                <p>Medical journals indexed in Science Citation Index Expanded (SCIE) of WOS and Scopus that are fully published in English were eligible for inclusion in the study. While journals that publish both clinical and basic sciences studies were included, journals that only publish articles in basic sciences, ethics, healthcare systems management, administration, and policy were excluded. Journals were divided into two groups based on their publishing model as either hybrid or gold OA.</p>
            </sec>
            <sec id="sec8">
                <title>Definitions</title>
                <p>

                    <list list-type="bullet">
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Hybrid journals: Journals that offer subscription-based and gold OA publishing options. Subscription-based publishing means that only users with access to the journal through an institutional or a personal subscription to the journal can get the full-text of the published articles.</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Gold OA journals: Journals that require authors to pay publishing fees that&#x2019;s commonly known as APC to have their articles fully visible and available for download to anyone immediately upon publishing.</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Impact factor (IF): 2-year IF of 2021-2022. It&#x2019;s calculated based on the number of citations of all the articles published in the journal within the last two years.</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>CiteScore: 3-year CiteScore of 2019-2022. It&#x2019;s calculated based on the number of citations of all the articles published in the journal within the last three years.</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Number of citations in WOS: The total number of times articles published in the journal were cited since journal&#x2019;s inception.</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Number of citations in Scopus: The total number of times articles published in the journal were cited between 2019-2022.</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Quartile: The quartile in which the journal is ranked, where Q1 involves the journals that are ranked the top 25% within a certain specialty, Q2 involves the journals that are ranked between 26-50%, Q3 involves the journals that are ranked between 51-75%, and Q4 involves the journals that are ranked between 76-100%. If a journal is ranked in more than one specialty, the average ranking was calculated.</p>
                        </list-item>
                    </list>
                </p>
                <p>The IF, CiteScore, number of citations, and quartile of each journal were collected from the journals&#x2019; records on Journal Citation Reports and Scopus.</p>
            </sec>
            <sec id="sec9">
                <title>Statistical analysis</title>
                <p>Categorical data were compared using Chi-square test and were presented as numbers and percentages, whereas continuous data were compared using Mann-Whitney test and presented using median [interquartile range (IQR)] as they were deemed skewed based on results of Shapiro-Wilk test of normality. Linear regression was conducted to assess the effect of different factors on IF and CiteScore. Multinomial regression was used to evaluate the association of different factors with Q1 ranking in WOS and Scopus. Odds ratios (OR) and 95% confidence intervals (CI) were reported. Fitting of the regression models was assessed using goodness-of-fit test. Omnibus test of significance was used to assess the significance of the regression models. A 
                    <italic toggle="yes">P</italic> value &lt; 0.05 was deemed statistically significant. Analyses were performed on SPSS version 24.0 (IBM Corp., Armonk, NY, USA).</p>
            </sec>
        </sec>
        <sec id="sec10" sec-type="results">
            <title>Results</title>
            <p>A total of 402 journals included, 201 in each group. 
                <xref ref-type="table" rid="T1">
Table 1</xref> shows the characteristics of the included journals. Hybrid and gold OA journals had a median [IQR] age of 32 [23&#x2013;41.5] and 21 [13&#x2013;28] years, respectively (
                <italic toggle="yes">P</italic> &lt; 0.001). Most of the journals were international (39.3% vs. 53.7%; 
                <italic toggle="yes">P</italic> &lt; 0.001). In terms of volumes and issues, hybrid journals publish more frequently per year than gold OA journals (8 vs. 6; 
                <italic toggle="yes">P</italic> = 0.041). However, 93 (46.3%) of the gold OA publish continuously; thus, were not included in the calculation of the median. More than half of the gold OA journals publish both clinical and basic sciences studies (35.3% vs. 53.2%; 
                <italic toggle="yes">P</italic> &lt; 0.001). The median [IQR] cost of publication in gold OA journals was 2,690 [2,000&#x2013;2,990]. Although a significant difference was observed in terms of IF between the hybrid and the gold OA publishing models (2.90 [2.20&#x2013;4.15] vs. 3.30 [2.40&#x2013;4.45]; 
                <italic toggle="yes">P</italic> = 0.021), no statistically significant difference was observed in terms of CiteScore, number of citations, and quartiles in both WOS and Scopus (
                <italic toggle="yes">P</italic> &gt; 0.05 for all comparisons).</p>
            <table-wrap id="T1" orientation="portrait" position="float">
                <label>
Table 1. </label>
                <caption>
                    <title>Characteristics of the journals based on their publishing model.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1" valign="top">Characteristic</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Hybrid (n=201)</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Gold Open-access (n=201)</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">

                                <italic toggle="yes">P</italic> value</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Journal age (years)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">32 [23&#x2013;41.5]</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">21 [13&#x2013;28]</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">&lt; 0.001</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Publisher
                                <sup>
                                    <xref ref-type="table-fn" rid="tfn1">*</xref>
                                </sup>
                            </td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="top">&lt; 0.001</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Springer</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">29 (14.4)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">48 (23.9)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Elsevier</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">38 (18.9)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">14 (7)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Wiley</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">25 (12.4)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">19 (9.4)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Taylor &amp; Francis</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">23 (11.4)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">13 (6.5)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Sage</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">11 (5.5)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (9)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Lippincott Williams &amp; Wilkins</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">17 (8.5)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 (0.5)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Cambridge</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">7 (3.5)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2 (1)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Other</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">51 (25.4)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">86 (42.7)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Journal&#x2019;s country
                                <sup>
                                    <xref ref-type="table-fn" rid="tfn1">*</xref>
                                </sup>
                            </td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="top">&lt; 0.001</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;International</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">79 (39.3)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">108 (53.7)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;USA</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">65 (32.3)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">31 (15.4)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;UK</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">16 (8)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">12 (6)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Canada</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">10 (5)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4 (2)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Japan</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">5 (2.5)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">5 (2.5)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Other</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">26 (12.9)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">41 (20.4)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Specialty
                                <sup>
                                    <xref ref-type="table-fn" rid="tfn1">*</xref>
                                </sup>
                            </td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="top">&lt; 0.001</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;General medicine</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">20 (10)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">32 (15.9)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Neurology/Neurosurgery</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">18 (9)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">11 (5.5)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Oncology</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">15 (7.4)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">14 (7)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Cardiology</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">12 (6)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">17 (8.4)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Endocrinology</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">13 (6.4)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">14 (7)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Other</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">123 (61.2)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">113 (56.2)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Publication frequency (per year)
                                <sup>
                                    <xref ref-type="table-fn" rid="tfn2">**</xref>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">8 [6&#x2013;12]</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">6 [4&#x2013;12]</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.041</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Journal published both clinical and basic sciences</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">71 (35.3)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">107 (53.2)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">&lt; 0.001</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Publication cost ($)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2,690 [2,000&#x2013;2,990]</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Year journal switched to gold OA (n=124)
                                <sup>
                                    <xref ref-type="table-fn" rid="tfn3">***</xref>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2014 [2008&#x2013;2019]</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Journal belongs to an organization</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">109 (54.2)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">96 (47.8)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.195</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Impact factor</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.9 [2.2&#x2013;4.2]</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.3 [2.4&#x2013;4.5]</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.021</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Quartile in WOS</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.163</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Q1</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">59 (29.4)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">52 (25.6)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Q2</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">59 (29.4)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">81 (40.3)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Q3</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">56 (27.9)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">48 (23.90</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Q4</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">27 (13.4)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">20 (10)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Number of citations in WOS</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4,918 [2,510&#x2013;8,648]</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3,963 [2,201&#x2013;8,915]</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.394</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">CiteScore</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">5.10 (3.60&#x2013;6.85)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">5 (3.55&#x2013;7.10)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.951</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Quartile in Scopus</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Q1</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">116 (57.7)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">88 (43.8)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Q2</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">64 (31.8)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">83 (41.3)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Q3</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">21 (10.4)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">30 (14.9)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Number of citations in Scopus</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2,420 [1,325&#x2013;4,521]</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2,972 [1,307&#x2013;6,486]</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.060</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Indexed in EMBASE</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">188 (93.5)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">181 (90)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.203</td>
                        </tr>
                    </tbody>
                </table>
                <table-wrap-foot>
                    <p>Data are presented as median [interquartile range] or n (%)</p>
                    <p>OA, open-access; WOS, Web of Science.</p>
                    <fn-group content-type="footnotes">
                        <fn id="tfn1">
                            <label>
                                <sup>*</sup>
                            </label>
                            <p>Only top 5 were listed.</p>
                        </fn>
                        <fn id="tfn2">
                            <label>
                                <sup>**</sup>
                            </label>
                            <p>n=93 of gold open-access journals publish continuously (i.e., without assigning articles to a volume or issue); hence, not included in this median.</p>
                        </fn>
                        <fn id="tfn3">
                            <label>
                                <sup>***</sup>
                            </label>
                            <p>The remaining 77 journals were open-access since inception.</p>
                        </fn>
                    </fn-group>
                </table-wrap-foot>
            </table-wrap>
            <p>When different factors were assessed for their effect on IF, only publishing both clinical and basic science studies was significantly associated with higher IF (OR, 2.03; 95% CI,1.19&#x2013;3.45; 
                <italic toggle="yes">P</italic> = 0.010). The same factor was associated with higher CiteScore (OR,3.63; 95% CI, 1.43&#x2013;9.20; 
                <italic toggle="yes">P</italic> = 0.007). On the other hand, the publishing model (hybrid vs. gold OA) did not influence IF nor CiteScore (OR, 1.38; 95% CI, 0.81&#x2013;2.36; 
                <italic toggle="yes">P</italic> = 0.237 and OR,0.81; 95% CI, 0.32&#x2013;2.04; 
                <italic toggle="yes">P</italic> =0.648, respectively). The effect of different factors on IF and CiteScore are shown in 
                <xref ref-type="table" rid="T2">
Tables 2</xref> and 
                <xref ref-type="table" rid="T3">3</xref>, respectively.</p>
            <table-wrap id="T2" orientation="portrait" position="float">
                <label>
Table 2. </label>
                <caption>
                    <title>Effect of different factors on impact factor.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1" valign="top">Factor</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">&#x03b2; Coefficient &#x00b1; SE</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">OR (95% confidence interval)</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">

                                <italic toggle="yes">P</italic> value</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Publishing model</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.234</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Hybrid</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Ref</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Ref</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Gold open-access
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.32 &#x00b1; 0.27</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1.38 (0.81&#x2013;2.36)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Journal&#x2019;s age</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.001 &#x00b1; 0.007</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 (0.99&#x2013;1.01)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.922</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Journal published both clinical and basic sciences</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.71 &#x00b1; 0.27</td>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.010</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Journal belongs to an organization</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.14 &#x00b1; 0.26</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1.15 (0.69&#x2013;1.91)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.597</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Indexed in EMBASE</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.62 &#x00b1; 0.48</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1.86 (0.72&#x2013;4.81)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.200</td>
                        </tr>
                    </tbody>
                </table>
            </table-wrap>
            <table-wrap id="T3" orientation="portrait" position="float">
                <label>
Table 3. </label>
                <caption>
                    <title>Effect of different factors on CiteScore.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1" valign="top">Factor</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">&#x03b2; Coefficient &#x00b1; SE</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">OR (95% confidence interval)</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">

                                <italic toggle="yes">P</italic> value</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Publishing model</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="top">0. 648</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Hybrid</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Ref</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Ref</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Gold open-access
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">-0.22 &#x00b1; 0.47</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.81 (0.32&#x2013;2.04)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Journal published both clinical and basic sciences</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1.29 &#x00b1; 0.47</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.63 (1.43&#x2013;9.2)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.007</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Journal belongs to an organization</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.05 &#x00b1; 0.46</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1.05 (0.43&#x2013;2.56)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.921</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Indexation in EMBASE</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.79 &#x00b1; 0.84</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.21 (0.42&#x2013;11.56)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.347</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Journal&#x2019;s age</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0 &#x00b1; 0.01</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1 (0.98&#x2013;1.02)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.982</td>
                        </tr>
                    </tbody>
                </table>
            </table-wrap>
            <p>The effect of different factors on the quartiles of the journals in WOS was evaluated, where none of the factors was associated with ranking in either quartile. 
                <xref ref-type="table" rid="T4">
Table 4</xref> lists the factors and their effect on ranking in Q1 of WOS. On the other hand, hybrid journals were associated with ranking in Q1 of Scopus as the odds of gold OA journals being ranked as Q1 was less than one (OR, 0.49; 95% CI 0.25&#x2013;0.94; 
                <italic toggle="yes">P</italic> = 0.032). 
                <xref ref-type="table" rid="T5">
Table 5</xref> lists the factors and their effect on ranking in Q1 of Scopus.</p>
            <table-wrap id="T4" orientation="portrait" position="float">
                <label>
Table 4. </label>
                <caption>
                    <title>Effect of different factors on Q1 ranking in Web of Science.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1" valign="top">Factor</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">OR (95% confidence interval)</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">

                                <italic toggle="yes">P</italic> value</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Publishing model</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Hybrid</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Ref</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Gold open-access
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1.19 (0.58&#x2013;2.43)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.638</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Journal published both clinical and basic sciences</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1.06 (0.52&#x2013;2.16)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.870</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Journal belongs to an organization</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1.29 (0.65&#x2013;2.58)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.468</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Indexation in EMBASE</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.38 (0.04&#x2013;3.33)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.384</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Journal&#x2019;s age</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1.00 (0.99&#x2013;1.02)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.914</td>
                        </tr>
                    </tbody>
                </table>
            </table-wrap>
            <table-wrap id="T5" orientation="portrait" position="float">
                <label>
Table 5. </label>
                <caption>
                    <title>Effect of different factors on Q1 ranking in Scopus.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1" valign="top">Factor</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">OR (95% confidence interval)</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">

                                <italic toggle="yes">P</italic> value</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Publishing model</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Hybrid</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Ref</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;Gold open-access
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.49 (0.25&#x2013;0.94)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.032</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Journal published both clinical and basic sciences</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.69 (0.36&#x2013;1.31)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.257</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Journal belongs to an organization</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1.50 (0.79&#x2013;2.83)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.214</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Indexation in EMBASE</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">&lt; 0.0001 (&lt; 0.0001&#x2013;&lt; 0.0001)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">&lt; 0.0001</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Journal&#x2019;s age</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.99 (0.97&#x2013;1.00)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.079</td>
                        </tr>
                    </tbody>
                </table>
            </table-wrap>
            <p>A subgroup analysis in the gold OA group to assess the effect of publishing cost on ranking in WOS showed that higher APCs were associated with Q3 ranking (OR, 2.76; 95% CI, 1.22&#x2013;6.23; 
                <italic toggle="yes">P</italic> = 0.015) and negatively associated with Q1 ranking (OR, 0.57; 95% CI, 0.26&#x2013;1.23; 
                <italic toggle="yes">P</italic> &lt; 0.001), but no effect was observed with Q2 ranking. The same observation was found with Q1 ranking in Scopus, where journals with high APCs were less likely to be ranked in Q1 (OR, 0.25; 95% CI, 0.11&#x2013;0.54; 
                <italic toggle="yes">P</italic> &lt; 0.001).</p>
        </sec>
        <sec id="sec11" sec-type="discussion">
            <title>Discussion</title>
            <p>This is the first study to evaluate the impact of gold OA publishing model on journals&#x2019; metrics. Findings from this study suggest that gold OA publishing model does not have an impact on IF or CiteScore despite the significant difference in IF, but not CiteScore, between hybrid and gold OA journals. These results align with findings from previous studies that explored similar themes, indicating that while OA models aim to increase accessibility, they do not necessarily confer a citation advantage over hybrid models.
                <sup>
                    <xref ref-type="bibr" rid="ref12">12</xref>,
                    <xref ref-type="bibr" rid="ref13">13</xref>
                </sup> For instance, some studies also found minimal differences in citation metrics between different publishing models, suggesting that other factors, such as journal reputation and article quality, might play more pivotal roles in influencing these metrics.
                <sup>
                    <xref ref-type="bibr" rid="ref14">14</xref>&#x2013;
                    <xref ref-type="bibr" rid="ref16">16</xref>
                </sup> A study by Chua et al found a higher number of citations of OA journals that did not correlate with IF (Spearman&#x2019;s rho = 0.187; 
                <italic toggle="yes">P</italic> = 0.60).
                <sup>
                    <xref ref-type="bibr" rid="ref16">16</xref>
                </sup> Similarly, the increment increase in IF with increased citations was minimal and not statistically significant (&#x03b2; coefficient = 3.35; 95% CI -0.464&#x2013;7.156; 
                <italic toggle="yes">P</italic> = 0.084).
                <sup>
                    <xref ref-type="bibr" rid="ref16">16</xref>
                </sup> As such, it is argued that the very high fees required by gold OA journals (reaching a median [IQR] of $2,690 [2,000&#x2013;2,990] and a range of $75&#x2013;5,460) are not justified when considering that many researchers call that science should be free to access by everyone. Therefore, these journals should consider lowering fees to cover necessary editorial processing and offer waivers for unfunded authors provided they provide a proof of lack of funds regardless of their country of origin (as many gold OA journals already offer waivers or discounts for authors from low-income countries). This approach aligns with the ethical imperative to democratize access to scientific knowledge, a sentiment echoed in the literature.
                <sup>
                    <xref ref-type="bibr" rid="ref14">14</xref>&#x2013;
                    <xref ref-type="bibr" rid="ref16">16</xref>
                </sup>
            </p>
            <p>Gold OA publishing model is a relatively new concept in research publishing as seen with the significant difference in the median [IQR] ages of hybrid and gold OA journals (32 [23&#x2013;41.5] vs. 21 [13&#x2013;28]; 
                <italic toggle="yes">P</italic> &lt; 0.001). Nonetheless, it become widespread, especially as many journals that were formerly hybrid have transitioned to gold OA, where the median [IQR] year of switching was 2014 [2008&#x2013;2019]. This transition is indicative of the broader shift in the publishing landscape towards more open access models, a trend noted in earlier studies.
                <sup>
                    <xref ref-type="bibr" rid="ref14">14</xref>,
                    <xref ref-type="bibr" rid="ref15">15</xref>
                </sup> Despite the significant difference in age, it is noteworthy that gold OA journals reached a median total number of citations in WOS since journals&#x2019; inception that was not statistically significant from that of hybrid journals, though it was numerically lower (3,963 vs. 4,918; 
                <italic toggle="yes">P</italic> = 0.351). This could be possibly attributed to the large number of gold OA journals (n=93 of 201; 46.3%) that publish articles continuously without assigning them to a certain volume or issue, unlike hybrid journals that have limited quotas. This observation resonates with previous reports that showed that continuous publication models might influence citation patterns differently compared to traditional issue-based models.
                <sup>
                    <xref ref-type="bibr" rid="ref14">14</xref>,
                    <xref ref-type="bibr" rid="ref15">15</xref>
                </sup>
            </p>
            <p>The lack of difference on the median total number of citations on Scopus reported for the years 2019&#x2013;2022 contradicts the hypothesis that gold OA could achieve a high impact within a short period, given that Scopus reports citations within a specific time frame rather than a lifetime total, as is the case with WOS. This discrepancy highlights the complexity of evaluating impact across different databases per previous reports.
                <sup>
                    <xref ref-type="bibr" rid="ref14">14</xref>,
                    <xref ref-type="bibr" rid="ref15">15</xref>
                </sup>
            </p>
            <p>Journals that publish using only gold OA model market themselves to researchers looking to gain more citations and broader readership.
                <sup>
                    <xref ref-type="bibr" rid="ref17">17</xref>
                </sup> Nevertheless, and contrary to that claim, the current study found no significant difference in the number of citations between gold OA and hybrid publishing models. Additionally, were observed more frequently with hybrid than with gold OA journals, while no difference was noted in the distribution of hybrid and gold OA journals among the different WOS quartiles. This outcome suggests that the prestige and perceived impact of hybrid journals may still hold sway in the academic community.
                <sup>
                    <xref ref-type="bibr" rid="ref14">14</xref>,
                    <xref ref-type="bibr" rid="ref15">15</xref>
                </sup> Moreover, in their studies, Gargouri, et al and McCabe, et al have emphasized the importance of publishing both basic science and clinical research to reach a broader audience. The ability of journals that encompass a wide range of disciplines to appeal to a diverse readership has been highlighted as a significant factor in increasing a journal&#x2019;s impact.
                <sup>
                    <xref ref-type="bibr" rid="ref14">14</xref>,
                    <xref ref-type="bibr" rid="ref15">15</xref>
                </sup> In the current study, this notion was supported by the observation that hybrid journals, which often publish a mix of basic and clinical research, were more likely to achieve higher quartile rankings in Scopus.</p>
            <p>These results of the current study suggest that unfunded researchers who cannot afford gold OA publishing should be less concerned about the citation impact of their work. It is worth noting that while articles published in subscription-based hybrid journals may not be freely accessible, readers can still obtain the full text by contacting the corresponding author via email or through researchers platforms like ResearchGate and Academia.edu.
                <sup>
                    <xref ref-type="bibr" rid="ref18">18</xref>
                </sup> This highlights the role of author accessibility in ensuring the wider dissemination of research findings, regardless of the publishing model. Nevertheless, the current study highlights the importance of considering the call for free access to scientific information. To promote equitable access, gold OA journals should offer lower fees and waivers for unfunded authors, regardless of their country of origin. By reducing financial barriers, these journals can facilitate the dissemination of research and contribute to the broader scientific community.</p>
            <p>It is important to acknowledge the strengths and limitations of this study. One of the strengths is that it is the first to directly compare the impact of hybrid and gold OA journals. By including a large random sample of journals and meeting the target sample size, the study provides a comprehensive analysis of the two models. It also evaluated several factors for their potential association with IF of WOS, CiteScore of Scopus, and quartiles of both databases. However, certain limitations should be considered. The study did not evaluate the impact of gold OA articles published in hybrid journals, which could potentially influence the overall impact comparison. Unfortunately, such an assessment was not feasible due to the longstanding existence of many hybrid journals. Additionally, journals that offer green OA, where articles become fully open access after an embargo period by paying page charges, were not included in the current study given their limited number, which could have made the comparison with the abundant hybrid and gold OA unjustified. Future research could explore the impact of these factors on citation metrics and readership. Further research is also warranted to investigate other aspects of OA publishing. While this study focused on IF and CiteScore, future studies could explore additional metrics such as altmetrics, which capture online attention and engagement with scholarly articles. Moreover, qualitative research methods could be employed to understand the perceptions and experiences of researchers regarding hybrid and gold OA publishing models. This would provide valuable insights into the decision-making processes and considerations of authors when choosing a publishing avenue. Furthermore, future research could delve deeper into understanding the impact of different research disciplines and the role of subject-specific factors in the citation patterns of hybrid and gold OA publications.</p>
        </sec>
        <sec id="sec12" sec-type="conclusion">
            <title>Conclusion</title>
            <p>In conclusion, the findings of this study have noteworthy implications for both researchers and publishers by providing empirical evidence on the impact of hybrid and gold OA journals. The findings suggest that journals&#x2019; impact and number of citations did not significantly differ between hybrid or gold OA publishing models. This challenges the idea that publishing in gold OA journals leads to a higher impact as measured by citation metrics such as the IF and CiteScore. The study also emphasizes the need for gold OA journals to offer lower fees and waivers for unfunded authors to promote free access to scientific information. This research sets the stage for further investigations into the various dimensions of open access publishing and its implications for scholarly communication.</p>
        </sec>
        <sec id="sec13">
            <title>Author contributions</title>
            <p>AKT: Conceptualization, methodology, data curation, investigation, supervision, project administration, writing &#x2013; original draft, and writing &#x2013; review &amp; editing. NIA: Data curation, investigation, writing &#x2013; original draft, and writing &#x2013; review &amp; editing. AOT and ASA: Data curation, investigation, and writing &#x2013; original draft.</p>
        </sec>
        <sec id="sec14">
            <title>Ethics and consent statement</title>
            <p>Not applicable.</p>
        </sec>
    </body>
    <back>
        <sec id="sec17" sec-type="data-availability">
            <title>Data availability statement</title>
            <p>Open Science Framework: Is publishing gold open-access worth it? An assessment of hybrid and gold open-access publishing models of medical journals on their impact. 
                <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.17605/OSF.IO/SXV3E">https://doi.org/10.17605/OSF.IO/SXV3E</ext-link>.
                <sup>
                    <xref ref-type="bibr" rid="ref19">19</xref>
                </sup>
            </p>
            <p>This project contains the following underlying data:
                <list list-type="bullet">
                    <list-item>
                        <label>&#x2022;</label>
                        <p>Open-access vs. Hybrid journals &#x2013; Supplementary material</p>
                    </list-item>
                </list>
            </p>
            <p>Data are available under the terms of the 
                <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International license</ext-link> (CC-BY 4.0).</p>
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                        </name>

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                            <surname>Krishnan</surname>
                            <given-names>V</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>The impact factor of an open access journal does not contribute to an article&#x2019;s citations.</article-title>
                    <source>

                        <italic toggle="yes">F1000Res.</italic>
</source>
                    <year>2017</year>;<volume>6</volume>:<fpage>208</fpage>. Epub 2017/06/27.
                    <pub-id pub-id-type="pmid">28649365</pub-id>
                    <pub-id pub-id-type="doi">10.12688/f1000research.10892.1</pub-id>
                    <pub-id pub-id-type="pmcid">PMC5464220</pub-id>
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                    <article-title>5 Reasons to choose immediate Gold open access as an author.</article-title>
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                        <italic toggle="yes">Springer Nature</italic>
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                    <year>2020 [10 June 2024]</year>.
                    <ext-link ext-link-type="uri" xlink:href="https://www.springernature.com/gp/researchers/the-source/blog/blogposts-open-research/5-reasons-to-choose-immediate-gold-open-access-as-an-author/18315168">Reference Source</ext-link>
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                            <given-names>S</given-names>
                        </name>
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                    <article-title>ResearchGate and Academia.edu as networked socio-technical systems for scholarly communication: a literature review.</article-title>
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                    <year>2018 02/20</year>;<volume>26</volume>.
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    <sub-article article-type="reviewer-report" id="report352795">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.175295.r352795</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Simard</surname>
                        <given-names>Marc-Andr&#x00e9;</given-names>
                    </name>
                    <xref ref-type="aff" rid="r352795a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0003-3795-0053</uri>
                </contrib>
                <aff id="r352795a1">
                    <label>1</label>Universite de Montreal, Montreal, Qu&#x00e9;bec, Canada</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>17</day>
                <month>1</month>
                <year>2025</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2025 Simard MA</copyright-statement>
                <copyright-year>2025</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport352795" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.159550.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>reject</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>This article compares the journal impact of hybrid and gold OA biomedical journals based on two proprietary data sources, namely Web of Science and Scopus. This study shows that, while it varies on certain conditions, gold OA journals may not result in more citations.</p>
            <p> </p>
            <p> I think criticism of gold OA is warranted, but I think the approach used by the authors is misguided because it ignores the market forces that are at play as well as other sociological factors that hybrid journals benefit from (e.g. publisher and journal reputation, prestige, green OA, transformative agreements, etc.).</p>
            <p> </p>
            <p> I also believe that the introduction is too short or not detailed enough and fails to grasp some of the main issues related to the topic such as publication prestige, impact, preprints, more inclusive data sources (such as OpenAlex and Dimensions), the for-profit nature of the system, article processing charges, OA policies and community infrastructure, transformative agreements, etc. The article would benefit from a more in-depth literature review. OA is a fast-changing topic involving multiple actors which the introduction does not accurately reflect.</p>
            <p> </p>
            <p> I also find the title/research question (Are gold journals worth it?) to be confusing as the article never really investigate more than research impact, which is only one of the facets (and I would argue it is the shallowest) of what makes OA/open science a more ethical choice. Furthermore, this link between research impact and publishing in OA journals is based on highly controversial and flawed journal-based metrics such as the impact factor and citescore, which are not a good predictor of individual article impact because the distribution of citations among journal articles is highly skewed (see Larivi&#x00e8;re and Sugimoto, 2018 [Ref 3]). Another problem with the design is that it doesn&#x2019;t not take into consideration the fact that hybrid OA articles can also be OA (via green or APC payment), and generally benefit from greater historical prestige than gold journals. Multiple studies have shown that green OA papers tend to receive more citations on average than other types of OA for that reason (e.g. Piwowar et al. 2018).</p>
            <p> </p>
            <p> In my opinion, the discussion/conclusion sections raise some valid points, but they are often too superficial and could use more depth and comprehension of the complex market forces at play. For instance, calling on gold OA publishers to lower APCs, while noble, is not a realistic or a sustainable approach because it doesn&#x2019;t consider the for-profit nature of the system and how these actors are taking advantage of OA to generate more profits (e.g. see Butler et al. 2023 [Ref 2]). There is also very little criticism of the hybrid model (and no APC average, when previous research has shown that they are higher than gold), when it is arguably even worse than gold journals: their APCs are higher, they charge both readers and authors, and are also parts of unsustainable transformative agreements. Why not also call them out on reducing their APC/subscription/transformative agreement prices?</p>
            <p> </p>
            <p> Some more specific comments:</p>
            <p> &#x00a0; 
                <list list-type="bullet">
                    <list-item>
                        <p>The abstract makes the false assumption that hybrid and gold are the most popular open access models, when both green and diamond are essentially just as big as the other two. The main difference is that they are generally not-for-profit, so they don&#x2019;t benefit from the same visibility or attention as the other two models.</p>
                    </list-item>
                    <list-item>
                        <p>There are some minor false information or assumption about OA: 
                            <list list-type="bullet">
                                <list-item>
                                    <p>Green OA doesn&#x2019;t necessarily mean embargos</p>
                                </list-item>
                                <list-item>
                                    <p>Green OA and page charges: green OA is free for authors in the vast majority of cases.</p>
                                </list-item>
                                <list-item>
                                    <p>Green OA is allowed by the vast majority of publishers</p>
                                </list-item>
                                <list-item>
                                    <p>Not all journals ask for APCs. There are more than 25 000 diamond OA journals (e.g. see Khanna et al. 2023 [Ref 1] or the Directory of open access journals)</p>
                                </list-item>
                            </list> </p>
                    </list-item>
                </list> Ultimately, I appreciate what the authors were trying to accomplish with this study, but I do believe that some major flaws in the study design (e.g. focusing on journal-based metrics) and assumptions that were made (e.g. ignoring specific factors about hybrid OA) hold it back to the point where I cannot approve of this article.</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>No</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Yes</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>No</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Partly</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Reviewer Expertise:</p>
            <p>open science, open access, bibliometrics, science of science</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above.</p>
        </body>
        <back>
            <ref-list>
                <title>References</title>
                <ref id="rep-ref-352795-1">
                    <label>1</label>
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                        <article-title>Recalibrating the scope of scholarly publishing: A modest step in a vast decolonization process</article-title>.
                        <source>
                            <italic>Quantitative Science Studies</italic>
                        </source>.<year>2022</year>;<volume>3</volume>(<issue>4</issue>) :
                        <elocation-id>10.1162/qss_a_00228</elocation-id>
                        <fpage>912</fpage>-<lpage>930</lpage>
                        <pub-id pub-id-type="doi">10.1162/qss_a_00228</pub-id>
                    </mixed-citation>
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                        <article-title>The oligopoly&#x2019;s shift to open access: How the big five academic publishers profit from article processing charges</article-title>.
                        <source>
                            <italic>Quantitative Science Studies</italic>
                        </source>.<year>2023</year>;<volume>4</volume>(<issue>4</issue>) :
                        <elocation-id>10.1162/qss_a_00272</elocation-id>
                        <fpage>778</fpage>-<lpage>799</lpage>
                        <pub-id pub-id-type="doi">10.1162/qss_a_00272</pub-id>
                    </mixed-citation>
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                <ref id="rep-ref-352795-3">
                    <label>3</label>
                    <mixed-citation publication-type="journal">
                        <person-group person-group-type="author"/>:
                        <article-title>Measuring Research</article-title>.<year>2018</year>;
                        <elocation-id>10.1093/wentk/9780190640118.001.0001</elocation-id>
                        <pub-id pub-id-type="doi">10.1093/wentk/9780190640118.001.0001</pub-id>
                    </mixed-citation>
                </ref>
            </ref-list>
        </back>
        <sub-article article-type="response" id="comment13634-352795">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Thabit</surname>
                            <given-names>Abrar</given-names>
                        </name>
                        <aff>Pharmacy Practice Department, King Abdulaziz University, Jeddah, Makkah Province, Saudi Arabia</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>26</day>
                    <month>3</month>
                    <year>2025</year>
                </pub-date>
            </front-stub>
            <body>
                <p>Dear Dr. Simard,</p>
                <p> </p>
                <p> We would like to thank you for taking the time to review and evaluate our manuscript. We have addressed all your comments and have revised the manuscript accordingly. An updated version of the manuscript highlighting the changes is attached. Please find below the responses to your comments.</p>
                <p> </p>
                <p> 1. I think criticism of gold OA is warranted, but I think the approach used by the authors is misguided because it ignores the market forces that are at play as well as other sociological factors that hybrid journals benefit from (e.g. publisher and journal reputation, prestige, green OA, transformative agreements, etc.).</p>
                <p> 
                    <bold>Response: </bold>Based on this comment and the comments made by reviewer 1, we have revised the manuscript to reflect the impact at the journal level, rather than the article level. Specifically, we commented in the discussion on the relation of the publishing model and their impact with journals&#x2019; reputation and prestige (lines 206-208 and 274-278).</p>
                <p> </p>
                <p> 2. I also believe that the introduction is too short or not detailed enough and fails to grasp some of the main issues related to the topic such as publication prestige, impact, preprints, more inclusive data sources (such as OpenAlex and Dimensions), the for-profit nature of the system, article processing charges, OA policies and community infrastructure, transformative agreements, etc. The article would benefit from a more in-depth literature review. OA is a fast-changing topic involving multiple actors which the introduction does not accurately reflect.</p>
                <p> 
                    <bold>Response: </bold>We have expanded the introduction to include many of the suggested topics in the reviewer&#x2019;s comment (lines 59-62, 67, and 74-83).</p>
                <p> </p>
                <p> 3. I also find the title/research question (Are gold journals worth it?) to be confusing as the article never really investigate more than research impact, which is only one of the facets (and I would argue it is the shallowest) of what makes OA/open science a more ethical choice. Furthermore, this link between research impact and publishing in OA journals is based on highly controversial and flawed journal-based metrics such as the impact factor and citescore, which are not a good predictor of individual article impact because the distribution of citations among journal articles is highly skewed (see Larivi&#x00e8;re and Sugimoto, 2018 [Ref 3]). Another problem with the design is that it doesn&#x2019;t not take into consideration the fact that hybrid OA articles can also be OA (via green or APC payment), and generally benefit from greater historical prestige than gold journals. Multiple studies have shown that green OA papers tend to receive more citations on average than other types of OA for that reason (e.g. Piwowar et al. 2018).</p>
                <p> 
                    <bold>Response: </bold>After the extensive revision that made to the manuscript, we have also revised the title to reflect the content and the consideration of the impact at the journal level rather than at the article level. We discussed the controversy regarding OA publishing based on the suggested reference (Sugimoto and Larivi&#x00e8;re) and another reference (Casadevall, et al) in the introduction (lines 78-83), as well as in the discussion (lines 272-278). Regarding the last point of considering that hybrid journals also have gold OA option, we have already acknowledged this as one of the limitations of our study (lines 284-287).</p>
                <p> </p>
                <p> 4. In my opinion, the discussion/conclusion sections raise some valid points, but they are often too superficial and could use more depth and comprehension of the complex market forces at play. For instance, calling on gold OA publishers to lower APCs, while noble, is not a realistic or a sustainable approach because it doesn&#x2019;t consider the for-profit nature of the system and how these actors are taking advantage of OA to generate more profits (e.g. see Butler et al. 2023 [Ref 2]). There is also very little criticism of the hybrid model (and no APC average, when previous research has shown that they are higher than gold), when it is arguably even worse than gold journals: their APCs are higher, they charge both readers and authors, and are also parts of unsustainable transformative agreements. Why not also call them out on reducing their APC/subscription/transformative agreement prices?</p>
                <p> 
                    <bold>Response: </bold>We completely agree with the argument presented by the reviewer. Therefore, and to address this comment, we added to the introduction the concern regarding the high APCs of hybrid journals and the high prices of transformative agreements (lines 59-62). Additionally, we also added this argument and the call to reduce these fees by hybrid journals in the same paragraph that called gold OA journals to reduce their APCs in the discussion (lines 265-271).</p>
                <p> </p>
                <p> 5. The abstract makes the false assumption that hybrid and gold are the most popular open access models, when both green and diamond are essentially just as big as the other two. The main difference is that they are generally not-for-profit, so they don&#x2019;t benefit from the same visibility or attention as the other two models.</p>
                <p> 
                    <bold>Response: </bold>We edited the sentence and removed &#x201c;the most&#x201d; before &#x201c;common publishing models (line 2).</p>
                <p> </p>
                <p> 6. There are some minor false information or assumption about OA: 
                    <list list-type="bullet">
                        <list-item>
                            <p>Green OA doesn&#x2019;t necessarily mean embargos</p>
                        </list-item>
                        <list-item>
                            <p>Green OA and page charges: green OA is free for authors in the vast majority of cases.</p>
                        </list-item>
                        <list-item>
                            <p>Green OA is allowed by the vast majority of publishers</p>
                        </list-item>
                        <list-item>
                            <p>Not all journals ask for APCs. There are more than 25 000 diamond OA journals (e.g. see Khanna et al. 2023 [Ref 1] or the Directory of open access journals).</p>
                        </list-item>
                    </list> 
                    <bold>Response: </bold>We corrected the information presented in the introduction regarding green OA and added appropriate citations (lines 33-38). We also added to the discussion a part discussing diamond OA and the number of journals adopting this model of publishing (lines 258-265).</p>
                <p> </p>
                <p> 7. Ultimately, I appreciate what the authors were trying to accomplish with this study, but I do believe that some major flaws in the study design (e.g. focusing on journal-based metrics) and assumptions that were made (e.g. ignoring specific factors about hybrid OA) hold it back to the point where I cannot approve of this article.</p>
                <p> 
                    <bold>Response: </bold>We appreciate the reviewer&#x2019;s feedback. As mentioned above, we have extensively revised the manuscript to describe the results from the journal-level perspective. We also added to the discussion the arguments regarding the financial barriers posed by both gold OA and hybrid journals. We hope that these revisions have improved the manuscript and its credibility.</p>
                <p> </p>
                <p> </p>
                <p> Respectfully;</p>
                <p> The corresponding author</p>
            </body>
        </sub-article>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report352802">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.175295.r352802</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Bouter</surname>
                        <given-names>Lex</given-names>
                    </name>
                    <xref ref-type="aff" rid="r352802a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-2659-5482</uri>
                </contrib>
                <aff id="r352802a1">
                    <label>1</label>Vrije Universiteit Amsterdam, Amsterdam, North Holland, The Netherlands</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>6</day>
                <month>1</month>
                <year>2025</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2025 Bouter L</copyright-statement>
                <copyright-year>2025</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport352802" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.159550.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>reject</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>In this article 201 hybrid and 201 gold medical open access journals are compared in terms of several citation-based indicators. The findings indicate that gold open access journals have a slightly higher Impact Factor and are more likely to be in Quartile 1 of Scopus. Strangely that first key finding is not mentioned in the abstract, while the second finding is formulated in a confusing way (&#x2018;&#x2026;wasn&#x2019;t significantly associated..&#x201d;).</p>
            <p> The narrative is somewhat difficult to follow, as there is a disconnect between the research question and the design of the study. The title (&#x2018;Is publishing gold open-access worth it?&#x2019;) doesn&#x2019;t state for whom this question will be answered. It turns out to boil down to the question whether the Article Processing Charge (APC) offers value for money in terms of impact from the author perspective. And this is where the disconnect comes in: the authors study impact at journal level, while authors will be interested in impact at article level. The problem is that indicators like the Impact Factor and other journal level indicators are poor predictors of the number of citations which a specific article in the journal at issue will get. There seems to be a growing consensus that gold open access publication leads to more citations and more citation diversity compared to paywalled publications. (See: Jeffrey Brainard. Open-access papers draw more citations from a broader readership. Science 24 January 2024. 
                <ext-link ext-link-type="uri" xlink:href="https://www.science.org/content/article/open-access-papers-draw-more-citations-broader-readership">https://www.science.org/content/article/open-access-papers-draw-more-citations-broader-readership</ext-link> ).</p>
            <p> But there are more reasons why the study design is less suitable to answer the research question: 
                <list list-type="bullet">
                    <list-item>
                        <p>Hybrid journals are a mix of gold open access and paywalled publications, which diminishes the contrast studied.</p>
                    </list-item>
                    <list-item>
                        <p>There are many differences between the included hybrid and gold open access journals that render causal interpretations very difficult. A much better study design would consist of a comparison between gold open access publications to a carefully matched group of similar paywalled publications.</p>
                    </list-item>
                    <list-item>
                        <p>No mention is made of open methods (preregistration, study protocol in public repository) or open data. Please repair or explain why this is not done.</p>
                    </list-item>
                    <list-item>
                        <p>Some indicators studied seem to concern absolute counts of citations. This is strange as the total number of articles will differ substantially between journals.</p>
                    </list-item>
                </list> Insufficient attention is given to the fact that from the perspective of authors both gold open access publications and paywalled publications suffer from financial barriers, as for both types of publications costs are involved that may be difficult to bear for authors or their institutions: APCs or journal subscriptions, respectively. The way forward might be diamond open access, but that promising solution is not mentioned in the article. The authors say that green open access involves page charges, which is not the case. (See e.g.: Open Access Network. 
                <ext-link ext-link-type="uri" xlink:href="https://open-access.network/en/information/open-access-primers/green-and-gold">https://open-access.network/en/information/open-access-primers/green-and-gold</ext-link>) Green open access (self-archiving), however, is correctly advocated as a way to make paywalled publications available for everyone, although that approach has a few disadvantages in terms of accessibility and sustainability.</p>
            <p> Finally, I sympathize with the plea to lower APC, but don&#x2019;t see the connection to the findings of the study. In summary, the research question cannot be answered well with the study design at issue and already seems to be answered by others.</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>No</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Partly</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>No</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>No</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>No</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>No</p>
            <p>Reviewer Expertise:</p>
            <p>Research Integrity, Open Science, Methodology</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above.</p>
        </body>
        <sub-article article-type="response" id="comment13633-352802">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Thabit</surname>
                            <given-names>Abrar</given-names>
                        </name>
                        <aff>Pharmacy Practice Department, King Abdulaziz University, Jeddah, Makkah Province, Saudi Arabia</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>26</day>
                    <month>3</month>
                    <year>2025</year>
                </pub-date>
            </front-stub>
            <body>
                <p>Dear Prof. Bouter,</p>
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                <p> We would like to thank you for taking the time to review and evaluate our manuscript. We have addressed all your comments and have revised the manuscript accordingly. An updated version of the manuscript highlighting the changes is attached. Please find below the responses to your comments.</p>
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                    <bold>1. In this article 201 hybrid and 201 gold medical open access journals are compared in terms of several citation-based indicators. The findings indicate that gold open access journals have a slightly higher Impact Factor and are more likely to be in Quartile 1 of Scopus. Strangely that first key finding is not mentioned in the abstract, while the second finding is formulated in a confusing way (&#x2018;&#x2026;wasn&#x2019;t significantly associated..&#x201d;).</bold>
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                    <bold>Response: </bold>We added the slight difference in IF; however, it was actually the hybrid journals that tended to have Q1 ranking in Scopus more than gold OA journals. We added both results to the abstract (lines 12-14).</p>
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                    <bold>2.&#x00a0;The narrative is somewhat difficult to follow, as there is a disconnect between the research question and the design of the study. The title (&#x2018;Is publishing gold open-access worth it?&#x2019;) doesn&#x2019;t state for whom this question will be answered. It turns out to boil down to the question whether the Article Processing Charge (APC) offers value for money in terms of impact from the author perspective. And this is where the disconnect comes in: the authors study impact at journal level, while authors will be interested in impact at article level. The problem is that indicators like the Impact Factor and other journal level indicators are poor predictors of the number of citations which a specific article in the journal at issue will get. There seems to be a growing consensus that gold open access publication leads to more citations and more citation diversity compared to paywalled publications. (See: Jeffrey Brainard. Open-access papers draw more citations from a broader readership. Science 24 January 2024. https://www.science.org/content/article/open-access-papers-draw-more-citations-broader-readership).</bold>
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                    <bold>Response: </bold>We highly appreciate the reviewer&#x2019;s highlight and the differentiation between the article level vs. the journal&#x2019;s level impact, particularly in terms of citation and the diversity of citations. While we did emphasize the impact of the model on the impact at the journal level, we have edited the claims that our findings have an impact at the article level and changed them to reflect the impact at the journal level. We have revised the manuscript, including the title, to reflect that our work focused on the impact at the journal level rather than at the article level (lines 74-83 in the introduction, as well as lines 152 and 220 in the discussion). We also cited the suggested article in the updated objective statement (line 78). In addition, we added to the discussion a paragraph on the differentiation between the two levels of impact and cited some of the studies mentioned in the article you kindly provided (lines 193-214).</p>
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                    <bold>3. But there are more reasons why the study design is less suitable to answer the research question:</bold> 
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                                <bold>Hybrid journals are a mix of gold open access and paywalled publications, which diminishes the contrast studied.</bold>
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                                <bold>There are many differences between the included hybrid and gold open access journals that render causal interpretations very difficult. A much better study design would consist of a comparison between gold open access publications to a carefully matched group of similar paywalled publications.</bold>
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                                <bold>No mention is made of open methods (preregistration, study protocol in public repository) or open data. Please repair or explain why this is not done.</bold>
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                                <bold>Some indicators studied seem to concern absolute counts of citations. This is strange as the total number of articles will differ substantially between journals.</bold>
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                    <bold> Response: </bold>Thank you for this extensive note. As in the case of any published research, limitations to the methodology can exist. 
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                            <p>We have already acknowledged the first point as one of the study limitations (lines 284-287).</p>
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                            <p>Regarding the second point, we did intend to include a random sample of journals. In order to control for the potential confounders and as an alternative to matching, we conducted multinomial logistic regression as described in the statistical analysis subsection of the methods. We added this justification to lines 128-129. However, we also added your point to the limitations as another way to control the confounders (lines 291-294).</p>
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                            <p>Regarding the third point, we added a clarification that only &#x201c;peer-reviewed&#x201d; journals (which are indexed in WOS and Scopus) were included. As such, the listed examples were excluded since they&#x2019;re not typically indexed (lines 89-92).</p>
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                            <p>We agree that the total number of articles and the number of citations should be considered together, which was resolved by the advent of IF and CiteScore. We added a footnote to Table 1 regarding this issue. We also removed from the main text of the results &#x201c;number of citations&#x201d; to avoid highlighting it as one of the key findings. Lastly, we removed from the discussion the paragraph commenting on the difference in the total number of citations between the two groups (lines 229-233). We also added a relevant discussion on this matter to lines 272-278 of the discussion.</p>
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                    <bold>4. Insufficient attention is given to the fact that from the perspective of authors both gold open access publications and paywalled publications suffer from financial barriers, as for both types of publications costs are involved that may be difficult to bear for authors or their institutions: APCs or journal subscriptions, respectively. The way forward might be diamond open access, but that promising solution is not mentioned in the article. The authors say that green open access involves page charges, which is not the case. (See e.g.: Open Access Network. https://open-access.network/en/information/open-access-primers/green-and-gold) Green open access (self-archiving), however, is correctly advocated as a way to make paywalled publications available for everyone, although that approach has a few disadvantages in terms of accessibility and sustainability.</bold>
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                    <bold>Response: </bold>We agree that we haven&#x2019;t given diamond OA sufficient attention and emphasized its importance given the financial barriers associated with both gold OA and subscription-based publishing. Therefore and to fill this gap, we added to the introduction a sentence defining diamond OA (lines 32-33). We also edited the statements defining green OA in the introduction and added the appropriate citations including the website suggested by the reviewer (lines 33-38). Moreover, we added a part discussing diamond OA and its importance in overcoming the financial barriers to the discussion section in comparison to gold OA and subscription-based publishing (lines 258-265).</p>
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                    <bold>5. Finally, I sympathize with the plea to lower APC, but don&#x2019;t see the connection to the findings of the study. In summary, the research question cannot be answered well with the study design at issue and already seems to be answered by others.</bold>
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                    <bold>Response: </bold>After adding the part discussing diamond OA and that it is still growing with a very limited number of journals adopting it compared with the number of gold OA journals, we believe that the context and the flow of this paragraph in the discussion provides a justification for this plea (lines 247-271).</p>
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                <p> Respectfully;</p>
                <p> The corresponding author</p>
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