<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN" "http://jats.nlm.nih.gov/publishing/1.2/JATS-journalpublishing1.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="research-article" dtd-version="1.2" xml:lang="en">
    <front>
        <journal-meta>
            <journal-id journal-id-type="pmc">F1000Research</journal-id>
            <journal-title-group>
                <journal-title>F1000Research</journal-title>
            </journal-title-group>
            <issn pub-type="epub">2046-1402</issn>
            <publisher>
                <publisher-name>F1000 Research Limited</publisher-name>
                <publisher-loc>London, UK</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="doi">10.12688/f1000research.159217.1</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Research Article</subject>
                </subj-group>
                <subj-group>
                    <subject>Articles</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Swedish abdominal massage versus warm water therapy on postoperative constipation: a comparison quasi-experimental study</article-title>
                <fn-group content-type="pub-status">
                    <fn>
                        <p>[version 1; peer review: 2 approved with reservations]</p>
                    </fn>
                </fn-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Boangmanalu</surname>
                        <given-names>Enny Selawaty</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0009-0006-2825-2930</uri>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="yes">
                    <name>
                        <surname>Masfuri</surname>
                        <given-names>Masfuri</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <xref ref-type="corresp" rid="c1">a</xref>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Adam</surname>
                        <given-names>Muhamad</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Nining</surname>
                        <given-names>Sri</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0001-5613-1227</uri>
                    <xref ref-type="aff" rid="a2">2</xref>
                    <xref ref-type="aff" rid="a3">3</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Banna</surname>
                        <given-names>Triani</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Funding Acquisition</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <uri content-type="orcid">https://orcid.org/0000-0001-5265-838X</uri>
                    <xref ref-type="aff" rid="a1">1</xref>
                    <xref ref-type="aff" rid="a4">4</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Pulungan</surname>
                        <given-names>Indira Mastura</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Funding Acquisition</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <aff id="a1">
                    <label>1</label>Faculty of Nursing, Universitas Indonesia, Depok, West Java, 16424, Indonesia</aff>
                <aff id="a2">
                    <label>2</label>Nursing Committee, Mother and Child Bunda Jakarta Hospital, Menteng, Central Jakarta, 10350, Indonesia</aff>
                <aff id="a3">
                    <label>3</label>Faculty of Nursing, Universitas Kristen Krida Wacana, West Jakarta, Jakarta, 12120, Indonesia</aff>
                <aff id="a4">
                    <label>4</label>Nursing Science, Sekolah Tinggi Ilmu Kesehatan Papua, Sorong City, West Papua, 98412, Indonesia</aff>
            </contrib-group>
            <author-notes>
                <corresp id="c1">
                    <label>a</label>
                    <email xlink:href="mailto:masfuri@ui.ac.id">masfuri@ui.ac.id</email>
                </corresp>
                <fn fn-type="conflict">
                    <p>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>18</day>
                <month>12</month>
                <year>2024</year>
            </pub-date>
            <pub-date pub-type="collection">
                <year>2024</year>
            </pub-date>
            <volume>13</volume>
            <elocation-id>1531</elocation-id>
            <history>
                <date date-type="accepted">
                    <day>29</day>
                    <month>11</month>
                    <year>2024</year>
                </date>
            </history>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2024 Boangmanalu ES et al.</copyright-statement>
                <copyright-year>2024</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <self-uri content-type="pdf" xlink:href="https://f1000research.com/articles/13-1531/pdf"/>
            <abstract>
                <sec>
                    <title>Background</title>
                    <p>Postoperative immobilizatiton for patients with lower extremity fractures causes constipation, which usually affects 50&#x2013;70% of patients. When it comes to nursing interventions for postoperative constipation, Swedish abdominal massage and warm water drinking therapy are two possible options.</p>
                </sec>
                <sec>
                    <title>Aim</title>
                    <p>The objective of this study is to compare the effectiveness of drinking warm water and Swedish abdominal massage on constipation scores on post-operative lower extremity fractures.</p>
                </sec>
                <sec>
                    <title>Methods</title>
                    <p>A quasi-experimental pre-posttest design without control group design was applied. 30 respondents used simple random sampling technique. The Constipation Assessment Scale (CAS) questionnaire was used to assess the patient&#x2019;s constipation levels before and after the intervention. The data analysis used independent t-test.</p>
                </sec>
                <sec>
                    <title>Results</title>
                    <p>The mean score of constipation of drinking water group after the intervention was 4.60 while abdominal Swedish massage was 3.56. Although both significantly reduced the constipation score, the p-value was 0.00.</p>
                </sec>
                <sec>
                    <title>Conclusion</title>
                    <p>The protocol of drinking warm water and Swedish abdominal massage immediately after waking up effectively reduced constipation scores on postoperative lower extremity fracture patients and can be use to adjuvant therapy. Further studies are needed to investigate postoperative constipation patients with immobility and the use of strong analgetics.</p>
                </sec>
            </abstract>
            <kwd-group kwd-group-type="author">
                <kwd>Closed Fracture Reduction</kwd>
                <kwd>Constipation</kwd>
                <kwd>Postoperative</kwd>
                <kwd>Swedish Abdominal Massage</kwd>
                <kwd>Warm Water Therapy</kwd>
            </kwd-group>
            <funding-group>
                <award-group id="fund-1">
                    <funding-source>The Indonesia Endowment Funds for Education (LPDP)</funding-source>
                </award-group>
                <award-group id="fund-2">
                    <funding-source>Center for Higher Education (BPPT)</funding-source>
                </award-group>
                <award-group id="fund-3">
                    <funding-source>the Directorate of Development and Research of Universitas Indonesia under the HIBAH PUTI 2023</funding-source>
                    <award-id>NKB-073/UN2.RST/HKP.05.00/2023</award-id>
                </award-group>
                <funding-statement>This study was supported &#x202f;by the Directorate of Development and Research of  Universitas Indonesia under the HIBAH PUTI 2023 (Grant No. NKB-073/UN2.RST/HKP.05.00/2023). We also want to express our sincere gratitude to The Center for Higher Education (BPPT) and The Indonesia Endowment Funds for Education (LPDP) for their support through scholarship programs that enabled us to conduct this study.  &#13;
&#13;
The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. </funding-statement>
                <funding-statement>
                    <italic>The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</italic>
                </funding-statement>
            </funding-group>
        </article-meta>
    </front>
    <body>
        <sec id="sec6">
            <title>Background</title>
            <p>According to the most recent data published in Lancet Healthy Longev, there were 178 million new fractures globally in 2019, and 455 million people had acute or chronic fracture symptoms at some point in their lives (
                <xref ref-type="bibr" rid="ref13">Global Burden of Disease, 2021</xref>). However after surgery, prolonged bed rest and limited movement inevitably result in adverse effects such as constipation (
                <xref ref-type="bibr" rid="ref28">Viberg et al., 2022</xref>). Constipation, which typically affects 50&#x2013;70% of patients, is brought on by the body&#x2019;s immobile state following surgery, which weakens intestinal peristalsis function in conjunction with dietary factors (
                <xref ref-type="bibr" rid="ref16">Jing &amp; Jia, 2019</xref>). Patients should be incredibly concerned about constipation because it can lead to a number of issues and negatively impact their quality of life (
                <xref ref-type="bibr" rid="ref17">Kamali et al., 2022</xref>). Consequently, constipation is a serious problem that, if disregarded, can result in psychological and physical problems. Laxative use is common among patients due to discomfort. Research shows that constipation affects 3% to 27% of people in the general population on an incidence rate of 5; in hospital settings, the prevalence is 79% (
                <xref ref-type="bibr" rid="ref25">Pehlivan &amp; Nural, 2022</xref>). However, in acute clinical practice, this condition is frequently overlooked when providing patient care (
                <xref ref-type="bibr" rid="ref27">Trads et al., 2018</xref>).</p>
            <p>Nurses have been treating constipation with a nursing intervention that includes teaching patients about high-fiber foods like vegetables and papaya (
                <xref ref-type="bibr" rid="ref12">Galica et al., 2022</xref>). But there has never been an application of another autonomous nursing intervention in the treatment room, like abdominal massage (
                <xref ref-type="bibr" rid="ref22">Nouhi et al., 2022</xref>). It is relatively inexpensive and something that sufferers can do on their own. Constant direct pressure is applied to the abdominal wall during abdominal massage, which is followed by a relaxation period. This increases the contractions of the rectum and intestines and the gastrocolic reflex (
                <xref ref-type="bibr" rid="ref29">Yao et al., 2020</xref>). Swedish abdominal massages are performed with light pressure on the tissue to promote comfort and enhance the digestive and blood circulation systems (
                <xref ref-type="bibr" rid="ref23">Park et al., 2023</xref>). By altering stomach pressure through mechanical and reflexive processes, abdominal massage can accelerate the passage of food through the digestive system and promote peristaltic movements (
                <xref ref-type="bibr" rid="ref11">Fekri et al., 2021</xref>). This procedure will speed up the movement of food through the digestive tract by increasing peristaltic movements and altering stomach pressure through mechanical and reflexive means (
                <xref ref-type="bibr" rid="ref21">Lafc&#x0131; &amp; Ka&#x015f;ik&#x00e7;i, 2023</xref>).</p>
            <p>To fill the stomach capacity, water is a good option. Using warm water as a complementary therapy is recommended (
                <xref ref-type="bibr" rid="ref20">Kilroe et al., 2024</xref>). The effects of hydrostatic, hydrodynamic, and warmth can promote relaxation and better blood circulation. The body responds to water to prevent, correct, and improve human health status, which makes water therapy one of the natural healing systems (
                <xref ref-type="bibr" rid="ref3">Asmaa Sayed et al., 2018</xref>). Warm water consumption will quicken the body&#x2019;s temperature regulation process because it requires less energy. Constipation will speed up the defecation process by using warm water to soften the stool (
                <xref ref-type="bibr" rid="ref24">Parsons et al., 2022</xref>). The aim of this study is to compare the effectiveness of drinking warm water and Swedish abdominal massage on constipation scores on post-operative lower extremity fractures.</p>
        </sec>
        <sec id="sec7" sec-type="methods">
            <title>Methods</title>
            <sec id="sec8">
                <title>Study design</title>
                <p>This research used quasi-experimental and pre-posttest designs without control group. This research was conducted at the Idaman Regional Public Hospital, Banjarbaru, South Kalimantan, Indonesia from May 10
                    <sup>th</sup> to June 30
                    <sup>th</sup> 2023.</p>
            </sec>
            <sec id="sec9">
                <title>Participants</title>
                <p>The sample was 30 respondents selected using simple random technique. Determination of the sample size of each group is determined by calculating the paired numerical comparative formula. The sample in this research selected randomly using a lottery. Randomization is done by lottery, which makes a list of all subjects to be studied, gives a number code to each item to be investigated, writes the code on a small paper, rolls up each paper, puts the rolled paper into a container then shakes or shakes the container and takes one by one the roll. If you get an odd number, the warm water consumption intervention will be carried out while if you get an even number, you will enter the Swedish abdominal massage intervention. The inclusion criteria were: (1) all post-operative orthopedic surgery patients with lower extremity fractures (fractures of the femur, pelvis, tibia, fibula, ankle, and pedis), (2) patients with casts, (3) post-operative orthopedic surgery patients with ORIF, (4) patients aged 17-60 years, (5) compos-mentis patient, (5) patients with post-operative day 1 (after 1&#x00d7;24 hours/POD 1), (6) patients with a Barthel index score &#x2264; 8 (severe dependence), (7) patients receiving a standard diet from the hospital.</p>
            </sec>
            <sec id="sec10">
                <title>Instrument</title>
                <p>This research used demographic questionnaire and the Constipation Assessment Scale (CAS) questionnaire to assess the patients&#x2019; constipation levels before and after the intervention. We used the Constipation Assessment Scale (CAS) that develop by McMillan and Williams and translated into Indonesian version by Suwandi. The valid CAS instrument in the Indonesian version consists of eight questions (
                    <xref ref-type="bibr" rid="ref26">Suwandi, 2017</xref>).</p>
            </sec>
            <sec id="sec11">
                <title>Intervention</title>
                <p>The sample was split into two intervention groups: group 2 got a Swedish abdominal massage, and group 1 drank warm water. 500 ml of warm water in a glass was consumed by group 1 at a temperature of 31.5&#x00b0;C. For three days, they drank the water as soon as they woke up and before breakfast. They were then permitted to eat breakfast 30 to 45 minutes after they had finished drinking. Over the course of three days, the second group, which was given a Swedish abdominal massage, had their abdominal muscles massaged for fifteen to twenty minutes. The moment when the respondents woke up, they were received this massage. It is recommended that patients refrain from eating breakfast following the intervention; however, they are permitted to consume food 30 to 45 minutes following the procedure. Every intervention was examined over the course of three days; the pretest was given prior to the intervention, and the post test was given following the third day of the intervention. The first time the respondent was able to defecate was used to calculate the defecation time.</p>
            </sec>
            <sec id="sec12">
                <title>Data collection</title>
                <p>The data were collected by the researchers. Questionnaires were distributed to each group before and after intervention.</p>
            </sec>
            <sec id="sec13">
                <title>Data analysis</title>
                <p>Descriptive statistical tests were used to measure demographic data or respondents&#x2019; characteristics. Data analysis was done with Windows-based IBM SPSS (Version 26.0) (
                    <xref ref-type="bibr" rid="ref15">IBM Corp, 2024</xref>). The data were normally distributed according to Shapiro-Wilk (p&#x2265;0.05), so the independent t-test was used to measure constipation scores. The data were normally distributed according to Shapiro-Wilk (p&#x2265;0.05), so the independent t-test was used to measure constipation scores.</p>
            </sec>
        </sec>
        <sec id="sec14" sec-type="results">
            <title>Results</title>
            <p>The participants&#x2019; characteristics such as age, gender, types of analgetics and constipation score were collected at baseline on 
                <xref ref-type="table" rid="T1">
Table 1</xref>.</p>
            <table-wrap id="T1" orientation="portrait" position="float">
                <label>
Table 1. </label>
                <caption>
                    <title>Respondent&#x2019;s characteristics.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="2" rowspan="2" valign="top">Characteristics</th>
                            <th align="left" colspan="2" rowspan="1" valign="top">Warm water drinking therapy (n = 15)</th>
                            <th align="left" colspan="2" rowspan="1" valign="top">Swedish abdominal massage (n = 15)</th>
                            <th align="left" colspan="2" rowspan="1" valign="top">Total (n = 30)</th>
                        </tr>
                        <tr>
                            <th align="left" colspan="1" rowspan="1" valign="top">n</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">%</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">n</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">%</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">
n</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">
%</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="8" rowspan="1" valign="top">
                                <bold>Gender</bold>
</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="2" rowspan="1" valign="middle">Female</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">4</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">26.66%</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">6</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">40%</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">10</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">33.3%</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="2" rowspan="1" valign="middle">Male</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">11</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">73.33%</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">9</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">60%</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">20</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">66.6%</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="2" rowspan="1" valign="middle">
                                <bold>Age</bold>
</td>
                            <td align="left" colspan="2" rowspan="1" valign="top">Mean (SD) 28.93 (14.97)</td>
                            <td align="left" colspan="2" rowspan="1" valign="top">Mean (SD) 31.53 (16.16)</td>
                            <td colspan="2" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="8" rowspan="1" valign="top">
                                <bold>Types of analgetic</bold>
</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="2" rowspan="1" valign="top">
                                <bold>Non-opioid
</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">15</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">100%</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">15</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">100%</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">30</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">100%</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="2" valign="middle">
                                <bold>Constipation Score</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Before</td>
                            <td align="left" colspan="2" rowspan="1" valign="top">Mean (SD) 8.40 (2.41)</td>
                            <td align="left" colspan="2" rowspan="1" valign="top">Mean (SD) 10.13 (1.80)</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">After</td>
                            <td align="left" colspan="2" rowspan="1" valign="top">Mean (SD) 4.60 (0.91)</td>
                            <td align="left" colspan="2" rowspan="1" valign="top">Mean (SD) 3.60 (0.63)</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                    </tbody>
                </table>
            </table-wrap>
            <p>According to this study, the majority of respondents&#x2014;11 (73.3%) and nine (60%), respectively&#x2014;were men who participated in the warm water intervention group and the Swedish abdominal massage intervention group. The first intervention group&#x2019;s average age was 28.93 years, while the second intervention group&#x2019;s average age was 31.53 years. The first intervention group&#x2019;s confidence interval fell between 17 and 60 years, while the second intervention group&#x2019;s confidence interval fell between 17 and 58 years. In both groups, non-opioid analgesics were used 100% of the time as analgesics. Prior to the intervention, the group receiving a Swedish abdominal massage had a higher mean constipation score than the group drinking warm water. On the other hand, the Swedish abdominal massage intervention group had a lower mean constipation score following the intervention. The statistical test found significant differences between the two intervention groups&#x2019; respondent characteristics (gender, age, and type of analgesic; p&gt;0.05), but not between the groups&#x2019; pre- and post-intervention characteristics.</p>
            <sec id="sec15">
                <title>Constipation scores of the warm water drinking therapy group and the swedish abdominal massage group</title>
                <p>The difference in constipation score was measured by looking at the mean score of the drinking warm water group and the Swedish abdominal massage group on 
                    <xref ref-type="table" rid="T2">
Table 2</xref>.</p>
                <table-wrap id="T2" orientation="portrait" position="float">
                    <label>
Table 2. </label>
                    <caption>
                        <title>Constipation scores of the warm water drinking therapy group (n = 15) and the swedish abdominal massage group (n = 15).</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="2" valign="top">Group</th>
                                <th align="left" colspan="1" rowspan="2" valign="top">Variable</th>
                                <th align="left" colspan="2" rowspan="1" valign="top">Mean (SD)
                                    <sup>
                                        <xref ref-type="table-fn" rid="tfn1">a</xref>
                                    </sup>
                                </th>
                                <th align="left" colspan="1" rowspan="2" valign="top">
p-value
                                    <sup>
                                        <xref ref-type="table-fn" rid="tfn2">b</xref>
                                    </sup>
                                </th>
                            </tr>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Pre test</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">
Post test</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Warm water drinking therapy</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Different constipation scores</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">3.80</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1.85</td>
                                <td align="left" colspan="1" rowspan="2" valign="middle">0.00
                                    <xref ref-type="table-fn" rid="tfn3">*</xref>
                                </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Swedish abdominal massage</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Different constipation scores</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">6.53</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1.68</td>
                            </tr>
                        </tbody>
                    </table>
                    <table-wrap-foot>
                        <fn-group content-type="footnotes">
                            <fn id="tfn1">
                                <label>
                                    <sup>a</sup>
                                </label>
                                <p>Mean (SD).</p>
                            </fn>
                            <fn id="tfn2">
                                <label>
                                    <sup>b</sup>
                                </label>
                                <p>Independent t-test.</p>
                            </fn>
                            <fn id="tfn3">
                                <label>*</label>
                                <p>Significant at p&lt;0.05.</p>
                            </fn>
                        </fn-group>
                    </table-wrap-foot>
                </table-wrap>
                <p>The independent t-test discovered a significantly different constipation scores between the group drinking warm water and the group having Swedish abdominal massage (p&lt;0.05). This result concludes a significantly different constipation score of the two groups. Prior to the intervention, the group receiving a Swedish abdominal massage scored higher (6.53) on the constipation score than the group drinking warm water (3.80). In the meantime, the warm water drinking group after the intervention scored higher on the constipation score (1.85) than the other group (1.68). Additionally, compared to the intervention group receiving Swedish abdominal massage, the warm water drinking group experienced a lower mean difference in changes to their constipation scores. When receiving a Swedish abdominal massage, the average time spent defecating was reduced to 54 hours, as opposed to 58.67 hours for the intervention group that drank warm water.</p>
            </sec>
        </sec>
        <sec id="sec16" sec-type="discussion">
            <title>Discussion</title>
            <p>The results showed that Swedish abdominal massage was noticeably more successful than warm water drinking therapy in reducing the constipation score. In addition to being an effective treatment for constipation, a Swedish abdominal massage can also lessen the degree of straining, anal pain, and bloating, as well as the degree of incomplete bowel emptying (
                <xref ref-type="bibr" rid="ref8">Choi et al., 2021</xref>). By strengthening the abdominal muscles and encouraging intestinal peristalsis, massage can improve the digestive system&#x2019;s efficiency, improving quality of life ratings and resulting in better-consistent stools (
                <xref ref-type="bibr" rid="ref9">Durmu&#x015f; &#x0130;skender &amp; &#x00c7;al&#x0131;&#x015f;kan, 2022</xref>). In order to cause contraction of the longitudinal and circular muscles&#x2014;the circular muscle encircling the lumen&#x2014;afferent neuron stretch receptors in the luminal wall are activated when a smooth muscle segment is distended with a pressure of about 2 mmHg. Simultaneously, the intestinal wall muscles contract a few centimeters in the area of higher pressure, while the muscles relax below the point of stimulation. These sensory neurons and nerve endings can be stimulated by abdominal massage (
                <xref ref-type="bibr" rid="ref4">Aydinli &amp; Karada&#x011f;, 2023</xref>; 
                <xref ref-type="bibr" rid="ref10">Faghihi et al., 2021</xref>). As a result, pressure is applied to the chyme, forcing it forward and causing the subsequent intestinal wall muscle segment to expand or contract. This, in turn, causes another contraction and produces a peristaltic wave (
                <xref ref-type="bibr" rid="ref19">Keely &amp; Barrett, 2022</xref>).</p>
            <p>For three days in a row, consuming 500 ml of warm water first thing in the morning can intensify the gastric effect and heighten the feeling of passing gas (
                <xref ref-type="bibr" rid="ref20">Kilroe et al., 2024</xref>). The best time to trigger the gastrocolic reflex is in the morning. This reflex happens when the extrinsic autonomic nerve, which is responsible for promoting colonic motility and large amplitude propagation (HAPCs) to ward off constipation, contracts the stomach when it reaches a specific volume (500 ml) (
                <xref ref-type="bibr" rid="ref1">Al-Kharraz et al., 2023</xref>). One to three glasses of water a day can help trigger the gastric reflex. Utilizing warm water is a complementary therapy. The warm, hydrostatic, and hydrodynamic effects can promote relaxation and better blood circulation (
                <xref ref-type="bibr" rid="ref3">Asmaa Sayed et al., 2018</xref>).</p>
            <p>Significant results were found in the majority of research studies that used warm water consumption at different volumes in conjunction with Swedish abdominal massage. The hypothesis posits that upon food entry, the large intestine experiences mass movements primarily due to the gastrocolic reflex (
                <xref ref-type="bibr" rid="ref5">Bellini et al., 2021</xref>). This reflex is facilitated by gastrin and parasympathetic innervation, which travel from the stomach to the large intestine (
                <xref ref-type="bibr" rid="ref7">Chatip et al., 2024</xref>). The urge to urinate frequently follows this reflex, which is most noticeable in many people after their first meal of the day. Therefore, a reflex is triggered to move the contents of the digestive tract farther along when new food enters, making room for the incoming food (
                <xref ref-type="bibr" rid="ref14">Gu et al., 2023</xref>). The remaining small intestine&#x2019;s contents are moved into the large intestine by the gastroileal reflex, and the defecation reflex is triggered by the gastrocolic reflex, which pushes the large intestine&#x2019;s contents into the rectum. This is so that the digestive system can function more efficiently. Peristalsis, or the stimulation of intestinal peristaltic movements, will be strengthened by abdominal massage (
                <xref ref-type="bibr" rid="ref18">Karaaslan et al., 2024</xref>).</p>
            <p>With the help of gastrin from the stomach and the extrinsic autonomic nerve, direct stimulation of the abdominal muscles can induce peristalsis and the gastrocolon, which causes the colon&#x2019;s mass to accelerate and the stomach&#x2019;s contractions to strongen (
                <xref ref-type="bibr" rid="ref7">Chatip et al., 2024</xref>). A gastroileal reflex will result in the movement of the remaining contents of the small intestine to the large intestine by forcing the chyme into the duodenum through strong peristaltic movements (
                <xref ref-type="bibr" rid="ref9">Durmu&#x015f; &#x0130;skender &amp; &#x00c7;al&#x0131;&#x015f;kan, 2022</xref>). This will speed up the absorption process in the intestine. A colon&#x2019;s contents will be forced into the rectum, a gastrocolon effect will be produced, stretch receptors in the rectal wall will be stimulated, and a feeling of defecation will be produced through good intestinal motility (
                <xref ref-type="bibr" rid="ref2">Artale et al., 2023</xref>).</p>
        </sec>
        <sec id="sec17" sec-type="conclusions">
            <title>Conclusion</title>
            <p>Both Swedish abdominal massage and warm water therapy are effective interventions for managing postoperative constipation. Each method offers specific advantages and can be considered based on patient preference and clinical context. Further research exploring long-term outcomes and comparative effectiveness with larger sample sizes would provide additional insights into optimizing postoperative care protocols for constipation management. This study&#x2019;s limitation was that, despite the respondents&#x2019; following hospital guidelines for diet, the amount of fiber and food portions were not calculated. Additionally, the location of the fracture could have an impact on mobilization; a more distal fracture location would facilitate easier food mobilization. A more proximal fracture location, however, will hinder the mobilization of food.</p>
        </sec>
        <sec id="sec20">
            <title>Ethical consideration</title>
            <p>This research was approved by the Ethics Commission of Idaman Regional Public Hospital, Banjarbaru with number No. RS00214/KEPK-RSDI/04/2023 on May 1
                <sup>st</sup> 2023. Before conducting the research, the researcher explained to the respondents about the objectives, procedures, and expectations of this research in person verbal and written. The respondents were asked to provide their written consent in an informed consent by signing before participating in this research. The respondents were also assured that their involvement was voluntary and were informed of their right to withdraw from the study at any time without facing any penalties
                <bold>.</bold>
            </p>
        </sec>
    </body>
    <back>
        <sec id="sec23" sec-type="data-availability">
            <title>Data availability</title>
            <sec id="sec24">
                <title>Underlying data</title>
                <p>Fighshare: Swedish Abdominal Massage versus Warm Water Therapy on Postoperative Constipation: A Comparison Quasi Experimental Study: 
                    <ext-link ext-link-type="uri" xlink:href="https://figshare.com/articles/journal_contribution/Swedish_Abdominal_Massage_versus_Warm_Water_Therapy_on_Postoperative_Constipation_A_Comparison_Quasi-Experimental_Study/27764655/2">10.6084/m9.figshare.27764655.v2</ext-link> (
                    <xref ref-type="bibr" rid="ref6">Boangmanalu, 2024</xref>).</p>
                <p>This project contains the following underlying data Click or tap here to enter text.
                    <list list-type="order">
                        <list-item>
                            <label>1.</label>
                            <p>SPO of Water Consumption</p>
                        </list-item>
                        <list-item>
                            <label>2.</label>
                            <p>SPO of Abdominal Massage</p>
                        </list-item>
                        <list-item>
                            <label>3.</label>
                            <p>SPSS Output</p>
                        </list-item>
                        <list-item>
                            <label>4.</label>
                            <p>All Data consist of all raw data underlying data before analysis in SPSS file</p>
                        </list-item>
                    </list>
                </p>
                <p>Data are available under the terms of the 
                    <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International license</ext-link> (CC-BY 4.0).</p>
            </sec>
            <sec id="sec18">
                <title>Extended data</title>
                <p>Fighshare: Swedish Abdominal Massage versus Warm Water Therapy on Postoperative Constipation: A Comparison Quasi Experimental Study: 
                    <ext-link ext-link-type="uri" xlink:href="https://figshare.com/articles/journal_contribution/Swedish_Abdominal_Massage_versus_Warm_Water_Therapy_on_Postoperative_Constipation_A_Comparison_Quasi-Experimental_Study/27764655/2">10.6084/m9.figshare.27764655.v2</ext-link> (
                    <xref ref-type="bibr" rid="ref6">Boangmanalu, 2024</xref>).</p>
                <p>This project contains the following extended dataClick or tap here to enter text.:
                    <list list-type="order">
                        <list-item>
                            <label>1.</label>
                            <p>Consort cheklist</p>
                        </list-item>
                        <list-item>
                            <label>2.</label>
                            <p>Research instrument</p>
                        </list-item>
                        <list-item>
                            <label>3.</label>
                            <p>Informed Consent</p>
                        </list-item>
                        <list-item>
                            <label>4.</label>
                            <p>Research explanation</p>
                        </list-item>
                    </list>
                </p>
                <p>Data are available under the terms of the 
                    <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International license</ext-link> (CC-BY 4.0).</p>
            </sec>
            <sec id="sec19">
                <title>Reporting guidelines</title>
                <p>Fighshare: 
                    <sans-serif>CONSORT checklist for</sans-serif> Swedish Abdominal Massage versus Warm Water Therapy on Postoperative Constipation: A Comparison Quasi Experimental Study: 
                    <ext-link ext-link-type="uri" xlink:href="https://figshare.com/articles/journal_contribution/Swedish_Abdominal_Massage_versus_Warm_Water_Therapy_on_Postoperative_Constipation_A_Comparison_Quasi-Experimental_Study/27764655/2">10.6084/m9.figshare.27764655.v2</ext-link> (
                    <xref ref-type="bibr" rid="ref6">Boangmanalu, 2024</xref>).</p>
                <p>Data are available under the terms of the 
                    <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International license</ext-link> (CC-BY 4.0).</p>
            </sec>
        </sec>
        <ack>
            <title>Acknowledgements</title>
            <p>This study was successfully conducted with the support of various parties. We want to thank the hospital where the study was carried out and the Faculty of Nursing, University of Indonesia. We also extend our gratitude to all participants and their families for their support in making this study possible.</p>
        </ack>
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    <sub-article article-type="reviewer-report" id="report357284">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.174914.r357284</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Miccio</surname>
                        <given-names>Robin S</given-names>
                    </name>
                    <xref ref-type="aff" rid="r357284a1">1</xref>
                    <role>Referee</role>
                </contrib>
                <aff id="r357284a1">
                    <label>1</label>Rutgers University, Newark, UK</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>11</day>
                <month>2</month>
                <year>2025</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2025 Miccio RS</copyright-statement>
                <copyright-year>2025</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport357284" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.159217.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>Overall, this is a wonderful study. My biggest concern is with the strong statement in the conclusion: &#x201c;The results showed that Swedish abdominal massage was noticeably more successful than warm water drinking therapy in reducing the constipation score.&#x201d; The heterogeneity between groups at baseline makes this statement not entirely true. The authors note that &#x201c;the statistical test found significant differences between the two intervention groups&#x2019; respondent characteristics (gender, age, and type of analgesic; p&gt;0.05).&#x201d; If the groups were significantly different at baseline, we are not comparing apples to apples. I&#x2019;m a bit confused with p&gt;0.05 &#x2013; if p is greater than 0.05 that usually means that there is NO significant difference between groups? Would statisticians consider Levine&#x2019;s Test to determine whether the assumption of homogeneity of variance is met? If there truly are differences at baseline, is another statistical test more appropriate to compare groups (like mixed-effects models)? If this is not possible, I think you can only compare pre and post data within groups (not between). It would also be good to note the limitations of a small sample size and report the effect size. Please note I am not a statistician, but thinking these areas need to be addressed.</p>
            <p> </p>
            <p> More information should be included about the groups. Such as: was the control group able to drink hot beverages during the intervention (i.e. tea or coffee), what about water consumption at baseline and throughout? Did the patients use laxatives at all? What other pain meds were used during the intervention (even non-opiate pain meds can cause constipation). From a massage therapist perspective, would be helpful to report details on the massage intervention &#x2013; how was massage applied: over clothes/on skin, what techniques, what position was the patient in, who performed the massage and what was their training?</p>
            <p> </p>
            <p> Lastly, the way the aim is worded is confusing. I think the word &#x201c;versus&#x201d; or &#x201c;against&#x201d; may help clarify. It is also in the end of the Intro. Example correction: The objective of this study is to compare the effectiveness of drinking warm water versus Swedish abdominal massage on constipation scores on post-operative lower extremity fractures.</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Yes</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Partly</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>No source data required</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Partly</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Partly</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Reviewer Expertise:</p>
            <p>Massage therapy</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
        <sub-article article-type="response" id="comment14074-357284">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Boangmanalu</surname>
                            <given-names>Enny Selawaty</given-names>
                        </name>
                        <aff>Faculty of Nursing, Universitas Indonesia, Depok, West Java, Indonesia</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>14</day>
                    <month>6</month>
                    <year>2025</year>
                </pub-date>
            </front-stub>
            <body>
                <p>Thank you for your feedback. We have reviewed and implemented your suggestions. All feedback has been addressed through revisions to the article.</p>
                <p> </p>
                <p> 1. 
                    <bold>Respon: </bold>The respondent characteristics (gender, age, and type of analgesic; p&gt;0.05) indicate that there was no significant difference between the two intervention groups&#x2014;those receiving warm water therapy and those receiving Swedish abdominal massage. This conclusion is supported by the statistical tests (p-value &gt; 0.05; &#x03b1; &#x2265; 0.05), which demonstrate no significant variance between the groups. The homogeneity of variance was tested using the chi-square test and Levene&#x2019;s test, confirming that the groups were comparable at baseline.</p>
                <p> </p>
                <p> 2. 
                    <bold>Respon:</bold> The homogeneity of respondent characteristics was tested using the chi-square test and Levine&#x2019;s test. These tests confirmed that the assumption of homogeneity of variance was met, allowing for valid comparisons between the intervention groups. We acknowledge that alternative statistical methods, such as mixed-effects models, may provide further insight, particularly if baseline differences were present. Additionally, we recognize the importance of discussing the limitations of our sample size and reporting the effect size for a more comprehensive analysis.</p>
                <p> </p>
                <p> 3. 
                    <bold>Respon: </bold>In the warm water therapy group, participants consumed 500 ml of warm water (temperature: approximately 31&#x00b0;C) each morning before breakfast. No other hot beverages (such as tea or coffee) were permitted during the intervention. Participants were allowed to eat breakfast 30-45 minutes after consuming the warm water.</p>
                <p> </p>
                <p> To minimize confounding factors, only non-opioid analgesics were used during the study, and no participants were given laxatives.</p>
                <p> </p>
                <p> The Swedish abdominal massage was performed directly on the skin, involving specific abdominal muscle movements. Each massage session lasted 15-20 minutes and was conducted daily for three consecutive days immediately after waking up. Patients remained in a supine position during the massage and were instructed to delay breakfast for 30-45 minutes post-intervention. The massages were administered by trained nurses, in accordance with their professional scope of practice under national nursing regulations.</p>
                <p> </p>
                <p> 
                    <bold>4. Respon: </bold>The objective of this study is to compare the effectiveness of drinking warm water versus Swedish abdominal massage on constipation scores on post-operative lower extremity fractures. We accept your advice, we have revised our article</p>
            </body>
        </sub-article>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report357292">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.174914.r357292</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Machado</surname>
                        <given-names>Nilton Carlos</given-names>
                    </name>
                    <xref ref-type="aff" rid="r357292a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0003-4769-1139</uri>
                </contrib>
                <aff id="r357292a1">
                    <label>1</label>S&#x00e3;o Paulo State University, S&#x00e3;o Paulo, Brazil</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>25</day>
                <month>1</month>
                <year>2025</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2025 Machado NC</copyright-statement>
                <copyright-year>2025</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport357292" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.159217.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>The authors present an enjoyable alternative for treating constipation. This study observed that its application was restricted to patients undergoing postoperative orthopedic surgery for lower extremity fractures (the femur, pelvis, tibia, fibula, ankle, and pedis).</p>
            <p> The study was elegantly designed and executed with great skill and accomplishment.</p>
            <p> The small number of patients is noteworthy. The term "Closed Fracture Reduction" does not fit well with the study. Perhaps a more fitting term could be suggested.</p>
            <p> Title. Please insert "postoperative orthopedic surgery" since the sample is restricted to this type of surgery.</p>
            <p> Please include the keywords in the abstract, title, and conclusions to increase the study's visibility.</p>
            <p> Results. Avoid repeating information in the text and Tables. In this manuscript, I think the variable "Gender" can be replaced by "Sex."</p>
            <p> Conclusions. Adequate e also concerning further studies.</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Yes</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Yes</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Yes</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Yes</p>
            <p>Reviewer Expertise:</p>
            <p>Pediatric Gastroenterology, Hepatology and Nutrition.</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
        <sub-article article-type="response" id="comment14073-357292">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Boangmanalu</surname>
                            <given-names>Enny Selawaty</given-names>
                        </name>
                        <aff>Faculty of Nursing, Universitas Indonesia, Depok, West Java, Indonesia</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>14</day>
                    <month>6</month>
                    <year>2025</year>
                </pub-date>
            </front-stub>
            <body>
                <p>Thank you for your feedback. We have reviewed and implemented your suggestions. All feedback has been addressed through revisions to the article.</p>
                <p> </p>
                <p> 1. The small number of patients is noteworthy. The term "Closed Fracture Reduction" does not fit well with the study. Perhaps a more fitting term could be suggested.</p>
                <p> Title. Please insert "postoperative orthopedic surgery" since the sample is restricted to this type of surgery.</p>
                <p> </p>
                <p> 
                    <bold>Response: </bold>Thank you for your insightful feedback. I will revise the article accordingly and consider using a more appropriate term. I will also update the title to reflect the specific focus on postoperative orthopedic surgery.
                    <bold> </bold>
                </p>
                <p> </p>
                <p> 2. Please include the keywords in the abstract, title, and conclusions to increase the study's visibility.</p>
                <p> </p>
                <p> 
                    <bold>Response: </bold>Thank you for your suggestion. We will ensure that the relevant keywords are incorporated into the abstract, title, and conclusions to enhance the study&#x2019;s visibility.</p>
                <p> </p>
                <p> 3. Results. Avoid repeating information in the text and Tables. In this manuscript, I think the variable "Gender" can be replaced by "Sex."</p>
                <p> </p>
                <p> 
                    <bold>Response: </bold>Thank you for your comment. We will revise the manuscript to avoid redundancy between the text and tables, and we will replace "Gender" with "Sex" as recommended.
                    <bold> </bold>
                </p>
                <p> </p>
                <p> 4. Conclusions. Adequate e also concerning further studies.</p>
                <p> </p>
                <p> 
                    <bold>Response: </bold>Thank you for the comment. We will revise the conclusion to better address this, emphasizing the importance of further research in this area.</p>
            </body>
        </sub-article>
    </sub-article>
</article>
