<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN" "http://jats.nlm.nih.gov/publishing/1.2/JATS-journalpublishing1.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="other" dtd-version="1.2" xml:lang="en">
    <front>
        <journal-meta>
            <journal-id journal-id-type="pmc">F1000Research</journal-id>
            <journal-title-group>
                <journal-title>F1000Research</journal-title>
            </journal-title-group>
            <issn pub-type="epub">2046-1402</issn>
            <publisher>
                <publisher-name>F1000 Research Limited</publisher-name>
                <publisher-loc>London, UK</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="doi">10.12688/f1000research.143569.1</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Case Study</subject>
                </subj-group>
                <subj-group>
                    <subject>Articles</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Nanotechnology applications in interior design of hospitals to enhance thermal comfort and decrease the infection spread for the occupants</article-title>
                <fn-group content-type="pub-status">
                    <fn>
                        <p>[version 1; peer review: awaiting peer review]</p>
                    </fn>
                </fn-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Ehab</surname>
                        <given-names>Toka</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Funding Acquisition</role>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Project Administration</role>
                    <role content-type="http://credit.niso.org/">Resources</role>
                    <role content-type="http://credit.niso.org/">Software</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0009-0004-4700-2596</uri>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="yes">
                    <name>
                        <surname>Hany</surname>
                        <given-names>Nermine</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <uri content-type="orcid">https://orcid.org/0000-0003-4816-3127</uri>
                    <xref ref-type="corresp" rid="c1">a</xref>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="yes">
                    <name>
                        <surname>Mosaad</surname>
                        <given-names>Gihan</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <xref ref-type="corresp" rid="c2">b</xref>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <aff id="a1">
                    <label>1</label>Architectural Department of Engineering &amp; Environmental Design, Arab Academy for Science Technology and Maritime Transport, Alexandria, Alexandria Governorate, 1029, Egypt</aff>
            </contrib-group>
            <author-notes>
                <corresp id="c1">
                    <label>a</label>
                    <email xlink:href="mailto:nermine.aly.hany@aast.edu">nermine.aly.hany@aast.edu</email>
                </corresp>
                <corresp id="c2">
                    <label>b</label>
                    <email xlink:href="mailto:Gihanmosaad90@gmail.com">Gihanmosaad90@gmail.com</email>
                </corresp>
                <fn fn-type="conflict">
                    <p>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>23</day>
                <month>4</month>
                <year>2024</year>
            </pub-date>
            <pub-date pub-type="collection">
                <year>2024</year>
            </pub-date>
            <volume>13</volume>
            <elocation-id>342</elocation-id>
            <history>
                <date date-type="accepted">
                    <day>28</day>
                    <month>3</month>
                    <year>2024</year>
                </date>
            </history>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2024 Ehab T et al.</copyright-statement>
                <copyright-year>2024</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
                <license>
                    <license-p>The author(s) is/are employees of the US Government and therefore domestic copyright protection in USA does not apply to this work. The work may be protected under the copyright laws of other jurisdictions when used in those jurisdictions.</license-p>
                </license>
            </permissions>
            <self-uri content-type="pdf" xlink:href="https://f1000research.com/articles/13-342/pdf"/>
            <abstract>
                <sec>
                    <title>Background</title>
                    <p>In healthcare facilities, the significance of sensitive architecture cannot be overstated. In regions facing challenges such as Egypt, the healthcare sector is grappling with deteriorating conditions. The design of hospitals is crucial for addressing the needs of patients with varying illnesses and for creating an environment that fosters psychological well-being. The interior design process, especially the selection of materials, plays a pivotal role in ensuring a hygienic and safe environment within healthcare facilities. Walls, floors, ceilings, and furniture materials are key elements that contribute to the overall design. A study was conducted to investigate the application of nano materials in healthcare facility interior design in Egypt.</p>
                </sec>
                <sec>
                    <title>Methods</title>
                    <p>The study involved first a literature review on nano technology and its application in healthcare interior spaces. It culminated in a framework and guidelines for nano materials in different hospital zones. The analytical part of the study analysed successful international examples, leading to a checklist of nanomaterials categorized by hospital zones. The third part involved a base case study in Alexandria, Egypt, simulating the impact of nano coatings on air temperature, radiant temperature, and relative humidity using the DesignBuilder software.</p>
                </sec>
                <sec>
                    <title>Results</title>
                    <p>The results demonstrated a positive impact on patient health and thermal comfort with nano materials. The use of nano coatings in interior design finishes resulted in decreases in air temperature, radiant temperature, and relative humidity. There was an average decrease of 12.3%-16.7% in air temperature, 3%-4.2% in radiant temperature, and 7%-12% in relative humidity throughout the year.</p>
                </sec>
                <sec>
                    <title>Conclusions</title>
                    <p>The study highlighted the effectiveness of nano technology in enhancing the interior finishes of healthcare buildings, leading to improved patient health, thermal comfort, and decreased infection spread rate. We provide valuable recommendations for optimizing material selection in existing hospital buildings in emphasizing potential benefits of nano materials in healthcare facility design.</p>
                </sec>
            </abstract>
            <kwd-group kwd-group-type="author">
                <kwd>Nanotechnology</kwd>
                <kwd>Nanomaterials</kwd>
                <kwd>Thermal Comfort</kwd>
                <kwd>hygenic items</kwd>
                <kwd>nanoparticles</kwd>
                <kwd>environmentally friendly</kwd>
                <kwd>durable</kwd>
                <kwd>long-term damage resistant</kwd>
            </kwd-group>
            <funding-group>
                <funding-statement>The author(s) declared that no grants were involved in supporting this work.</funding-statement>
            </funding-group>
        </article-meta>
    </front>
    <body>
        <sec id="sec5" sec-type="intro">
            <title>Introduction</title>
            <p>Healthcare design is a novel technique that looks into human demands on a psychological and social level additionally to traditional biological and financial ones. Included in this strategy, interior design was seen as a crucial component across a healthcare facility&#x2019;s whole life cycle. Interior finishes are a important parts of the environment in healthcare institutions.
                <sup>
                    <xref ref-type="bibr" rid="ref1">1</xref>
                </sup> Hospital facilities&#x2019; floors, walls and ceiling coverings, and accessories all play a significant part in maintaining a healthy environment. As a result, during the design phase, the criterion for selecting new up to date finishing materials must take precedence therefore the power of nanotechnology to manipulate materials has the potential to alter the world.
                <sup>
                    <xref ref-type="bibr" rid="ref2">2</xref>
                </sup>
                <sup>&#x2013;</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref4">4</xref>
                </sup>
            </p>
            <p>Through the use of materials with nanoscale properties that enhance their properties and their development. Nano scaled materials have been the subject of research, and it has been discovered that these new materials have different chemical and physical properties, are more effective, and perform better than conventional materials.
                <sup>
                    <xref ref-type="bibr" rid="ref5">5</xref>
                </sup> One of the biggest challenges to achieving sanitary features and maintaining a healthy atmosphere in hospitals is the application of nanomaterials in interior spaces such as patient room and surgery room.
                <sup>
                    <xref ref-type="bibr" rid="ref2">2</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref5">5</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref6">6</xref>
                </sup>
            </p>
            <p>According to previous research nanomaterials used in interior finishing materials. Nano is accustomed to using conventional materials to get around obstacles that
                <sup>
                    <xref ref-type="bibr" rid="ref5">5</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref7">7</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref8">8</xref>
                </sup>:
                <list list-type="bullet">
                    <list-item>
                        <label>-</label>
                        <p>Make a contribution to the spread of infection since they possess characteristics that reduce the likelihood of various finishing material issues that develop in hospitals.</p>
                    </list-item>
                    <list-item>
                        <label>-</label>
                        <p>Minimize the number of bacteria, mold, and fungi that are visible on the surfaces and stop the creation of an environment that encourages their growth.</p>
                    </list-item>
                    <list-item>
                        <label>-</label>
                        <p>In addition to disinfection and cleaning, chemical hazards that produce harmful gases that harm human health should be minimized.
                            <sup>
                                <xref ref-type="bibr" rid="ref1">1</xref>
                            </sup>
                        </p>
                    </list-item>
                    <list-item>
                        <label>-</label>
                        <p>Assists in keeping hospitals&#x2019; environments healthy.
                            <sup>
                                <xref ref-type="bibr" rid="ref9">9</xref>
                            </sup>
                        </p>
                    </list-item>
                </list>
            </p>
            <p>The three primary variables influencing thermal comfort, according to research are air temperature, radiant temperature, and relative humidity.
                <sup>
                    <xref ref-type="bibr" rid="ref9">9</xref>
                </sup> This is a important finding because it shows how these variables directly affect the health of patients and medical personnel. The results point to a group of nanomaterials that could be used to improve air temperature and quality in hospital interior finishes.
                <sup>
                    <xref ref-type="bibr" rid="ref3">3</xref>
                </sup>
            </p>
            <sec id="sec6">
                <title>Research problem</title>
                <p>The majority of hospitals in Egypt use poor materials in interior design finishes. This makes patients more susceptible to pandemics in hospitals as a result of high temperatures and the spread of bacteria and viruses on surfaces. All caused by the fact that the selecting of interior materials finishes in hospitals is synchronized with hospital patient health and well-being, which are important components of a sustainable environment in health care sector and a healthy community, particularly in the future after the pandemic.</p>
            </sec>
            <sec id="sec7">
                <title>Research aim</title>
                <p>The research aims to investigate the effectiveness of nanomaterials application in healthcare sector in interior design in Egypt and to present the advantages of using nanomaterials on thermal comfort in interior spaces, the profound shifts they will bring about in society, and how they can be used to create interior environments that are sustainable.
                    <sup>
                        <xref ref-type="bibr" rid="ref4">4</xref>
                    </sup>
                </p>
            </sec>
        </sec>
        <sec id="sec8" sec-type="methods">
            <title>Methods</title>
            <p>The study focuses on the effectiveness &amp; classifications of Nano materials according to interior zones of hospitals and used local hospital &#x201c;Elite Hospital&#x201d; as a case study. The study encompassed three parts.</p>
            <sec id="sec9">
                <title>Literature review</title>
                <p>The first part is a literature review on nanotechnology definition, database (shown in 
                    <xref ref-type="table" rid="T1">Table 1</xref>), then materials examples (shown in 
                    <xref ref-type="table" rid="T2">Table 2</xref>), then coatings (shown in 
                    <xref ref-type="table" rid="T3">Table 3</xref>), nano insulation (shown in 
                    <xref ref-type="table" rid="T4">Table 4</xref>) and finally textiles classifications and its application in healthcare interior spaces, resulting in the development of a framework and guidelines for the utilization of nano materials across various hospital zones.</p>
                <table-wrap id="T1" orientation="portrait" position="float">
                    <label>Table 1. </label>
                    <caption>
                        <title>Nano materials data bases and websites.
                            <sup>
                                <xref ref-type="bibr" rid="ref10">10</xref>
                            </sup>
                        </title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Database</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">website</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Records</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Remark</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">caNanoLab</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <ext-link ext-link-type="uri" xlink:href="https://cananolab.nci.nih.gov/">https://cananolab.nci.nih.gov/</ext-link>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1383</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Nanotechnology in biomedicine</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">eNanoMapper</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <ext-link ext-link-type="uri" xlink:href="https://data.enanomapper.net/">https://data.enanomapper.net/</ext-link>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2380</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Safety assessment of nanomaterials</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">NR</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <ext-link ext-link-type="uri" xlink:href="https://nanomaterialregistry.net/">https://nanomaterialregistry.net/</ext-link>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2031</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Physicochemical properties</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Nanowerk</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <ext-link ext-link-type="uri" xlink:href="https://www.nanowerk.com/">https://www.nanowerk.com/</ext-link>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">3785</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Commercially available nanomaterials</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">NBIK</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <ext-link ext-link-type="uri" xlink:href="http://nbi.oregonstate.edu/">http://nbi.oregonstate.edu/</ext-link>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">147</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Exposure effect in embryo zebrafish</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">NIL</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <ext-link ext-link-type="uri" xlink:href="http://nanoparticlelibrary.net/">http://nanoparticlelibrary.net/</ext-link>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">88</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Physicochemical characteristics</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">NKB</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <ext-link ext-link-type="uri" xlink:href="https://ssl.biomax.de/nanocommons/">https://ssl.biomax.de/nanocommons/</ext-link>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">598</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Nano-safety knowledge infrastructure</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <table-wrap id="T2" orientation="portrait" position="float">
                    <label>Table 2. </label>
                    <caption>
                        <title>Nano materials application and their funtions.
                            <sup>
                                <xref ref-type="bibr" rid="ref2">2</xref>
                            </sup>
                            <sup>,</sup>
                            <sup>
                                <xref ref-type="bibr" rid="ref3">3</xref>
                            </sup>
                        </title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Nanomaterial (examples)</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Function</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Effect</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Industrial applied</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Oxides:
                                    <break/>
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Titanium dioxide</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Iron Oxide</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Silicone dioxide</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Chromium Oxide</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Color effect</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Reproducible paints</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Stop the development of cracks</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Improved ability to withstand fading</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Construction</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Furniture</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Organic hybrid polymers</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Colloidal/nano silica embedded</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Titanium dioxide</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Self-Cleaning</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Repels water and dirt.</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Preventative graffiti removal</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Defence against algae and fungi</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Glass</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Construction (Facades)</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Silicon dioxide</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Aluminium oxide</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Scratch Resistance</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Increased resistance to scratches</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Parquet flooring</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Furniture</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Titanium dioxide</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Silver</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Photocatalytic effect</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Anti-microbical effect</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Elimination of filth, bacteria, algae, and grease</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Wood preservation</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Glass construction (facades, tiles, noise barriers)</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Titanium Dioxide</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Fire retardant</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>It produces a layer of carbon foam that works to insulate the wood&#x2019;s surface from heat, and then it produces a layer of ceramic that resists flames</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Wood production against fire construction</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Titanium Dioxide</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Zinc Oxide</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Iron Oxide pigments</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>UV protection</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>IR absorbing</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Regulate the indoor air quality</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Increased resistance to UV</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Glass</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Plastic</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Wood preservation</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Construction</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <table-wrap id="T3" orientation="portrait" position="float">
                    <label>Table 3. </label>
                    <caption>
                        <title>Different types of coatings and their properties.
                            <sup>
                                <xref ref-type="bibr" rid="ref1">1</xref>
                            </sup>
                            <sup>,</sup>
                            <sup>
                                <xref ref-type="bibr" rid="ref3">3</xref>
                            </sup>
                        </title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="5" rowspan="1" valign="top">Coatings</th>
                            </tr>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Product:</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Self-cleaning (Lotus-Effect)</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Self-cleaning (Photo catalysis)</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Easy-to-clean (ETC)</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Antibacterial</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Properties:</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Water is hydrophobic</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Dribbles out</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Hydrophilic surfaces</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Broken-down dirt that has been deposited is left loose on the surface</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Water-repellent, hydrophobic, and frequently oleophobic</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Surface repellency without the use of the Lotus Effect</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Specifically target and eliminate bacteria.</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Parameters:</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Rough in a microscale, not smooth.
                                    <break/>Ideal for surfaces that receive regular exposure to adequate amounts of water.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Dirt gets washed away by a water film.
                                    <break/>Water and UV light are necessary.
                                    <break/>There is an improvement in light transmission through translucent membranes and glazing.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Less attractive surfaces that are smooth.
                                    <break/>Because of a drop in surface energy, Surface attraction is less strong on surfaces.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Disinfectants can be used less frequently.
                                    <break/>Silver nanoparticles cut down on the amount of time needed for cleaning.</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Uses:</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">To make better use of it as well as low-maintenance facades that clean themselves.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Lessens the degree to which dirt sticks to surfaces.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Are most frequently used indoors, although they can also be used for improved protection from the weather.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Supports good hygiene practises, particularly in settings related to healthcare.</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <table-wrap id="T4" orientation="portrait" position="float">
                    <label>Table 4. </label>
                    <caption>
                        <title>Different types of nano insulation and their properties.
                            <sup>
                                <xref ref-type="bibr" rid="ref7">7</xref>
                            </sup>
                            <sup>,</sup>
                            <sup>
                                <xref ref-type="bibr" rid="ref13">13</xref>
                            </sup>
                        </title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="3" rowspan="1" valign="top">Nano insulation</th>
                            </tr>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Material</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Properties</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Features</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">-Aerogel</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Hydrophobic Surfaces</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Transparence so it is used for windows.</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Extremely effective insulation.</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Lightweight.</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">-VIPs</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Hydrophilic Surfaces</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>It is incredibly thin in profile.</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Fits in small spaces for creative constructions.</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Exceptional thermal insulation performance.</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">-PCMs</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">For all types of surfaces</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Applied to all interior space components, including ceiling, walls, floors, and windows.</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Excellent thermal insulation performance.</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Allows for creative builds in tight spaces.</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                            </tr>
                        </tbody>
                    </table>
                    <table-wrap-foot>
                        <p>PCMs: Phase Change Materials, VIPs: Vacuum Insulation Panels.</p>
                    </table-wrap-foot>
                </table-wrap>
            </sec>
            <sec id="sec10">
                <title>Analytical phase</title>
                <p>Second part is the analytical phase of the research examined three successful international examples using nano materials, leading to the creation of a checklist categorizing nanomaterials based on hospital zones. The three examples are firstly Joe DiMaggio Children&#x2019;s Hospital, then Katz Women&#x2019;s Hospital and finally Lucile Packard Children&#x2019;s Hospital</p>
            </sec>
            <sec id="sec11">
                <title>Base case study</title>
                <p>Third part is a base case study (Elite Hospital) conducted in Alexandria, Egypt, where in the impact of nano coatings on air temperature, radiant temperature, and relative humidity was simulated using the 
                    <ext-link ext-link-type="uri" xlink:href="https://designbuilder.co.uk/">DesignBuilder</ext-link> software (version 6.1.0.006). For readers and reviewers to replicate the study, I have included information on &#x201c;
                    <ext-link ext-link-type="uri" xlink:href="https://openstudio.net/">OpenStudio</ext-link>&#x201d; as an equivalent open-access software and by simulating the selected area four times, first simulation by using the located material used on the floor (ceramic) in the hospital to identify the room temperature and compare it with the three new temperatures results with nano materials used in the simulation. The three materials utilized in the simulation, namely ceramic with nano properties, epoxy with nano properties, and marble with nano properties, following this specified order.</p>
                <p>The methodology of the research is designed to study the effectiveness of Nano materials in interior spaces on the thermal comfort in Egypt&#x2019;s hospitals followed by the analysis of three successful international examples using nano materials with same conditions of the case study last but not least to propose a checklist of Nano materials applicable to hospitals interior finishes in Egypt and simulate the case study with DesignBuilder software and compare it with local materials used in the patient room.</p>
                <p>Thus, the focus in the literature review on four concepts: Nano material products, Nano coatings, insulation and textiles to carry out the relevant features on hospitals in Egypt. then, the study of hospital buildings to analyse the effects of nano materials on the interior design environment and understand the application of Nano technology materials in hospital buildings to conclude with a checklist of Nano materials that will be applied to the case study building. &#x201c;ELITE Hospital&#x201d; in Alexandria, Egypt.</p>
                <p>This research&#x2019;s methodology involved simulating the case study building&#x2019;s air temperature, radiant temperature and relative humidity in two stages using the Design Builder computer program.</p>
            </sec>
            <sec id="sec12">
                <title>Base case simulation</title>
                <p>The following methodical and exacting procedure were followed in order to guarantee the applicability of the results produced by the Design Builder software:
                    <list list-type="order">
                        <list-item>
                            <label>1.</label>
                            <p>
                                <italic toggle="yes">Data gathering</italic>
                            </p>
                            <p>Compile precise and thorough information about the interior finishes of Elite hospital, including the walls built by mud bricks and covered by paints, ceilings covered with gypsumboard tiles and floors covered with caeramic tiles.</p>
                            <p>Utilized through: Site visits and their website are the ways in which this data can be acquired.</p>
                        </list-item>
                        <list-item>
                            <label>2.</label>
                            <p>
                                <italic toggle="yes">Model creation</italic>
                            </p>
                            <p>Using the Design Builder program, the base case model version the hospital room with all its details and accuracy while taking into account all pertinent inputs and parameters. I have changed the finishing materials with nano materials provided in Egypt like the walls were simulated by aerogel insulation between the walls and covered by titanium dioxide added to paints, ceilings are covered with (Nano-Coated Paints) Nanotechnology-enhanced paints can offer features like antimicrobial properties, self-cleaning surfaces, and improved durability. These coatings may also resist stains and moisture and floors are covered with (Nano-Ceramic Tiles) Nano-ceramic tiles can offer improved strength, resistance to stains, and easier maintenance. They are commonly used in various flooring applications.</p>
                            <p>Utilized through: This entails entering the information that the researcher has gathered.</p>
                        </list-item>
                        <list-item>
                            <label>3.</label>
                            <p>
                                <italic toggle="yes">Adjustment</italic>
                            </p>
                            <p>To increase the model&#x2019;s accuracy, Adjust it by contrasting the anticipated temperature with the temperature data for the building materials. You can do this by adjusting the inputs as needed.</p>
                            <p>Utilized through: Until the model is precisely calibrated&#x2014;which is not possible in this situation&#x2014;this procedure entails iteratively changing the parameters for the input, running the simulation and contrasting the results with actual data.</p>
                        </list-item>
                        <list-item>
                            <label>4.</label>
                            <p>
                                <italic toggle="yes">Detailed analysis</italic>
                            </p>
                            <p>To find out how sensitive, the output of the model is to adjust the input parameters and to pinpoint key factors influencing the building&#x2019;s materials and air temperature in the building.</p>
                            <p>Utilized through: This stage offers insights into how to enhance the model and assists in determining the key factors influencing the building&#x2019;s materials.</p>
                        </list-item>
                        <list-item>
                            <label>5.</label>
                            <p>
                                <italic toggle="yes">Verification</italic>
                            </p>
                            <p>Can verify the model&#x2019;s accuracy by comparing its predicted results with independent data sources, like published literature or other tested models.</p>
                            <p>Utilized through: By taking this step, you can make sure that the model is trustworthy and capable of making accurate predictions. The simulation&#x2019;s base case air temperature is compared to Alexandria actual weather data in this paper.</p>
                        </list-item>
                        <list-item>
                            <label>6.</label>
                            <p>
                                <italic toggle="yes">Documentation</italic>
                            </p>
                            <p>Record the steps involved in creating the model, such as the assumptions made the input data as well as any modifications made in the stages of calibration and verification.</p>
                            <p>Utilized through: The source data, presumptions, and any changes made throughout the calibration and verification processes should all be included in this documentation. Ensuring that it is possible to update and maintain the model as needed over time is another benefit of having proper documentation.</p>
                            <p>Second post implementation simulation: Simulating air temperature, radiant temperature and relative humidity by using three different nano materials in Design builder software program.</p>
                        </list-item>
                        <list-item>
                            <label>7.</label>
                            <p>
                                <italic toggle="yes">Collect data</italic>
                            </p>
                            <p>Study and collect through the literature review the main properties of Nano technology used in interior finishing materials.</p>
                            <p>Utilized through: use this properties in the simulation of post-implementation in Design Builder software</p>
                        </list-item>
                        <list-item>
                            <label>8.</label>
                            <p>
                                <italic toggle="yes">Analyzation</italic>
                            </p>
                            <p>Analyzing successful example awarded by LEED certificate by using nanomaterials in interior finishing.</p>
                            <p>Utilized through: determine and coordinate the Nano materials used in (patient room) finishing materials according to zone space</p>
                        </list-item>
                        <list-item>
                            <label>9.</label>
                            <p>
                                <italic toggle="yes">Create materials</italic>
                            </p>
                            <p>Creating materials with physical and chemical properties of nanomaterials. I have used ceramic with nano properties, epoxy with nano properties, and marble with nano properties</p>
                            <p>Utilized through: identify the main parameters of interest with respect to nano particle safety are two:
                                <list list-type="alpha-upper">
                                    <list-item>
                                        <label>A.</label>
                                        <p>Physical properties: size, shape, aspect ratio, specific surface ratio, agglomeration, size distribution, surface morphology, structure including crystallinity and defect structure, and solubility.</p>
                                    </list-item>
                                    <list-item>
                                        <label>B.</label>
                                        <p>Chemical properties: structural formula/molecular structure, purity degree, phase identity, surface chemistry (composition, charge, tension, reactive sites, physical structure, photocatalytic properties) and hydrophilicity.</p>
                                    </list-item>
                                </list>
                            </p>
                        </list-item>
                        <list-item>
                            <label>10.</label>
                            <p>
                                <italic toggle="yes">Simulate and compare</italic>
                            </p>
                            <p>Simulating the added Nano materials in the same room with base condition.</p>
                            <p>Utilized through: simulate air temperature, radiant temperature and relative humidity by using Design builder software and compare it with the base case.</p>
                        </list-item>
                    </list>
                </p>
            </sec>
        </sec>
        <sec id="sec13">
            <title>Literature review</title>
            <p>The literature review consists of multiple sections: first, the definition of nano technology. Second, nano materials characteristics. Third, nano material products and it&#x2019;s benefits. The literature also discusses the application of nano materials in health care sector that can be added to finishing materials in interior finishes explained into the coatings, insulation and textiles parts in literature review.</p>
            <sec id="sec14">
                <title>Nano technology</title>
                <p>The goal of &#x201c;nanotechnology&#x201d; is the study, design, combination and application of materials with the aim of controlling a substance at the nanoscale. These novel and precisely atomic structures like carbon nanotubes or the smallest instruments for viewing the human body mark the beginning of an as yet unfathomably advanced technological era. (Advanced and environmentally friendly technology), nanotechnology is a promising field of scientific research that promises &#x201c;more for less.&#x201d; It provides strategies for developing smarter, more efficient, lighter, cheaper, and faster gadgets that can accomplish more tasks with fewer resources and less energy use (Sustainable Environment). There are numerous instances of nanotechnology applications, ranging from straightforward to intricate.
                    <sup>
                        <xref ref-type="bibr" rid="ref11">11</xref>
                    </sup>
                    <sup>&#x2013;</sup>
                    <sup>
                        <xref ref-type="bibr" rid="ref13">13</xref>
                    </sup>
                </p>
                <p>For example, nano coatings can prevent hospital-borne infections from spreading or discourage dirt, reducing the need for hazardous cleaning agents.
                    <sup>
                        <xref ref-type="bibr" rid="ref11">11</xref>
                    </sup>
                </p>
                <p>In contrast to more modern engineering endeavours, nature created &#x201c;Nanotechnologies&#x201d; over billions of years by using enzymes and catalysts to precisely arrange various atoms and molecules into intricate microscopic structures that support life. These organic goods are incredibly powerful and possess incredible qualities, such as:
                    <list list-type="order">
                        <list-item>
                            <label>1.</label>
                            <p>The capacity for transform materials and harness solar energy.
                                <sup>
                                    <xref ref-type="bibr" rid="ref13">13</xref>
                                </sup>
                            </p>
                        </list-item>
                        <list-item>
                            <label>2.</label>
                            <p>Water is incorporated into living cells, allowing for the storage and processing of enormous quantities of data by vast arrays of neurons.
                                <sup>
                                    <xref ref-type="bibr" rid="ref14">14</xref>
                                </sup>
                            </p>
                        </list-item>
                        <list-item>
                            <label>3.</label>
                            <p>In order to accurately replicate the billions of informational bits found in DNA molecules.
                                <sup>
                                    <xref ref-type="bibr" rid="ref3">3</xref>
                                </sup>
                            </p>
                        </list-item>
                        <list-item>
                            <label>4.</label>
                            <p>Nano materials play an important role in air temperature.
                                <sup>
                                    <xref ref-type="bibr" rid="ref3">3</xref>
                                </sup>
                            </p>
                        </list-item>
                    </list>
                </p>
                <p>For Qualities differences in the behaviour of materials at the nanoscale, there are two main causes:
                    <list list-type="order">
                        <list-item>
                            <label>1- </label>
                            <p>At very small dimensions, quantum mechanical processes come into play and give rise to novel physics and chemistry (biotechnology).
                                <sup>
                                    <xref ref-type="bibr" rid="ref11">11</xref>
                                </sup>
                            </p>
                        </list-item>
                        <list-item>
                            <label>2- </label>
                            <p>At the nanoscale, one distinctive feature of these structures (in biotechnology) is their extraordinarily high surface-to-volume ratio.
                                <sup>
                                    <xref ref-type="bibr" rid="ref7">7</xref>
                                </sup>
                                <sup>,</sup>
                                <sup>
                                    <xref ref-type="bibr" rid="ref15">15</xref>
                                </sup>
                            </p>
                        </list-item>
                    </list>
                </p>
                <p>Because of quantum mechanical processes, materials created at the &#x201c;Nanoscale,&#x201d; which is commonly measured in nanometers, or billionths of a metre, occasionally exhibit special physical and chemical properties. Consumer products are beginning to use materials that have been nanoengineered, and electronic engineering now requires proficiency in these techniques. For example, Millions of microscopic &#x201c;Nano whiskers,&#x201d; each measuring about ten nanometers, have been chemically bonded to synthetic and natural fibres to add silver nanocrystals to bandages that inhibit infection and kill bacteria. Zinc oxide nanocrystals have been used to create UV-blocking invisible sunscreens.
                    <sup>
                        <xref ref-type="bibr" rid="ref6">6</xref>
                    </sup>
                </p>
                <p>When discussing the advantages of new technologies and their impact on sustainable development, it is important to consider the following points, especially in the context of nanotechnology.
                    <list list-type="bullet">
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Added benefit.</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Additional features.</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Product development in relation to market demand.</p>
                        </list-item>
                    </list>
                </p>
                <p>Long-term demand will lead to the establishment of certain materials and goods while the eradication of others from the market. Because it responds to a constant need for innovation rather than being an aim in itself, the usage of nanotechnology can also be a marketing component.
                    <sup>
                        <xref ref-type="bibr" rid="ref9">9</xref>
                    </sup> The following fields, independent of marketing considerations (economic sustainability), can benefit significantly from nanotechnology
                    <sup>
                        <xref ref-type="bibr" rid="ref16">16</xref>
                    </sup>:
                    <list list-type="bullet">
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Improving current items.</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Protection from harm.</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>A reduction in volume or weight.</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>A decrease in the quantity of manufacturing phases.</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>A more effective use of resources.</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Less maintenance (longer cleaning intervals, easier to clean) and/or operational maintenance is necessary.</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>And consequently, directly, there will be:</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>A decrease in the use of energy and raw materials, as well as a decrease in CO
                                <sub>2</sub> emissions, all of which will benefit the environment.</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Resources should be conserved.</p>
                        </list-item>
                    </list>
                </p>
            </sec>
            <sec id="sec15">
                <title>Nano material definition</title>
                <p>A nano technological approach grounded in materials science is used in the field of nanomaterials. It examines materials having nanoscale morphological characteristics, particularly those with unique properties resulting from their nanoscale dimensions.
                    <sup>
                        <xref ref-type="bibr" rid="ref16">16</xref>
                    </sup> Although materials smaller than one micrometre are also occasionally referred to by this term, the conventional definition of the nanoscale is anything smaller than one tenth of a micrometre in at least one dimension.
                    <sup>
                        <xref ref-type="bibr" rid="ref4">4</xref>
                    </sup>
                    <sup>,</sup>
                    <sup>
                        <xref ref-type="bibr" rid="ref17">17</xref>
                    </sup>
                </p>
                <p>An object with at the minimum one dimension in the nanometre scale is called a nanomaterial. Dimensions are used to categorize nanomaterials.
                    <sup>
                        <xref ref-type="bibr" rid="ref11">11</xref>
                    </sup>
                </p>
            </sec>
            <sec id="sec16">
                <title>Nano material products &amp; benefits</title>
                <p>Sustainability and nanotechnology usage in construction and interior finishes are closely related. Many countries have said that they want to increase energy efficiency and cut greenhouse gas emissions. The Kyoto Protocol&#x2019;s first phase comes to an end in 2012, and a subsequent accord will specify further measures.
                    <sup>
                        <xref ref-type="bibr" rid="ref8">8</xref>
                    </sup>
                    <sup>,</sup>
                    <sup>
                        <xref ref-type="bibr" rid="ref14">14</xref>
                    </sup> By 2050, carbon dioxide emissions must be cut in half worldwide, and this can only be done via determined and, most importantly, quick action. Construction must consequently be energy efficient, especially given that it is a major source of CO
                    <sub>2</sub> emissions.
                    <sup>
                        <xref ref-type="bibr" rid="ref13">13</xref>
                    </sup>
                    <sup>,</sup>
                    <sup>
                        <xref ref-type="bibr" rid="ref14">14</xref>
                    </sup>
                </p>
                <p>It is up to planners and architects to come up with novel approaches to halting climate change and fusing ambitious design with energy efficiency. By means of creativity, architecture, interior design, and other associated fields can now utilise materials and surface qualities made feasible by nanotechnology to increase energy efficiency and build more sustainably as shown in 
                    <xref ref-type="table" rid="T2">Table 2</xref>.
                    <sup>
                        <xref ref-type="bibr" rid="ref3">3</xref>
                    </sup>
                    <sup>,</sup>
                    <sup>
                        <xref ref-type="bibr" rid="ref12">12</xref>
                    </sup>
                </p>
                <p>Using nanotechnology to its fullest potential and fostering innovation through its assistance are the goals of nanomaterials. This ensures that nanotechnology is used for long-term benefits, independent of fads or trends. To realise the implications and design possibilities, one must have a basic understanding of the many functional options. Therefore, rather than listing the points in order of the physical or chemical principles upon which based, like photocatalysis, the following has been arranged in accordance with the qualities that surfaces and nanomaterials provide, like self-cleaning and air purification.
                    <sup>
                        <xref ref-type="bibr" rid="ref5">5</xref>
                    </sup>
                    <sup>,</sup>
                    <sup>
                        <xref ref-type="bibr" rid="ref7">7</xref>
                    </sup>
                </p>
            </sec>
            <sec id="sec17">
                <title>Coatings (Finishing materials)</title>
                <p>Coatings for steel, glass, concrete, and other materials are being researched in the vast field of nanotechnology. In this work, a lot of different techniques like Spray, Meniscus, Dip, Vapour Deposition (CVD), and Plasma Coating utilized to form a layer that is bonded to the foundation material and produces a surface with the required functional or protective qualities.</p>
                <p>One of the objectives of the research, as shown in 
                    <xref ref-type="table" rid="T3">Table 3</xref>, is to endow the ability to heal itself through a procedure known as &#x201c;self-assembly&#x201d; by using different types of coatings.
                    <sup>
                        <xref ref-type="bibr" rid="ref5">5</xref>
                    </sup>
                    <sup>,</sup>
                    <sup>
                        <xref ref-type="bibr" rid="ref16">16</xref>
                    </sup>
                </p>
                <p>Nanotechnology is currently being used to make paints, which have insulating qualities due to the addition of nanoscale pores, cells, and particles. This results in extremely limited thermal conduction paths and doubles the insulating foam&#x2019;s R values.
                    <sup>
                        <xref ref-type="bibr" rid="ref5">5</xref>
                    </sup>
                </p>
            </sec>
            <sec id="sec18">
                <title>Insulation</title>
                <p>Nanotechnology and insulation have the potential to improve insulation&#x2019;s efficiency, reduce its dependency on non-renewable resources, and lessen its toxicity. These promises are being fulfilled to a large extent already. According to manufacturers, insulating materials made possible by nanotechnology are roughly 30% more effective than conventional materials.
                    <sup>
                        <xref ref-type="bibr" rid="ref9">9</xref>
                    </sup> Since they have a very high surface-to-volume ratio and can hold air in a layer of the substance, nanoscale materials have a lot of potential as insulators. As shown in 
                    <xref ref-type="table" rid="T4">Table 4</xref> explains the insulating properties of nanomaterials, which are used in some designs as coatings, thin films, or sandwiched between rigid panels.
                    <sup>
                        <xref ref-type="bibr" rid="ref13">13</xref>
                    </sup>
                    <sup>,</sup>
                    <sup>
                        <xref ref-type="bibr" rid="ref14">14</xref>
                    </sup>
                </p>
                <p>Three different kinds of insulating nanomaterials exist:
                    <list list-type="bullet">
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Phase Change Materials (PCMs)</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Thermal Insulation: Aerogel</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Vacuum Insulation Panels (VIPs)</p>
                        </list-item>
                    </list>
                </p>
            </sec>
            <sec id="sec19">
                <title>Textiles</title>
                <p>Materials that eliminate bacteria, lessen moisture and odour, and stop static electricity are produced from fabrics that have been coated with nanoparticles at every stage of the manufacturing process. When polymer nanofiber coatings are applied to textiles, the material at one end of the polymer bonds to the coating, creating a surface covered in tiny, hair-like structures. Smart textiles are materials that possess the capacity to perceive and respond to external cues or triggers originating from mechanical, thermal, magnetic, chemical, electrical, or additional sources.
                    <sup>
                        <xref ref-type="bibr" rid="ref14">14</xref>
                    </sup>
                </p>
                <p>
                    <italic toggle="yes">Smart textiles classification: (as the following)</italic>
                    <list list-type="alpha-upper">
                        <list-item>
                            <label>A)</label>
                            <p>Passive smart textiles</p>
                            <p>The initial iterations of smart textiles, which supplementary additional functionality in a passive manner, disregarding changes in the surrounding environment For instance, no matter the weather, a incredibly insulating coat would still offer the same amount of insulation.
                                <sup>
                                    <xref ref-type="bibr" rid="ref18">18</xref>
                                </sup> Other attributes that fall into this broad category are bulletproof, anti-microbial, anti-odour, and anti-static.
                                <sup>
                                    <xref ref-type="bibr" rid="ref5">5</xref>
                                </sup>
                                <sup>,</sup>
                                <sup>
                                    <xref ref-type="bibr" rid="ref16">16</xref>
                                </sup>
                                <sup>,</sup>
                                <sup>
                                    <xref ref-type="bibr" rid="ref19">19</xref>
                                </sup>
                            </p>
                        </list-item>
                        <list-item>
                            <label>B)</label>
                            <p>Active smart textiles</p>
                            <p>The second generation includes both sensors and actuators. Active smart textiles adapt to shifting environmental conditions by themselves. Active smart textiles include shape memory, chameleon, thermocontrolled, vapour-absorbing, heat-evolving, water-resistant, and vapour-permeable (hydrophilic/nonporous) fabrics.
                                <sup>
                                    <xref ref-type="bibr" rid="ref17">17</xref>
                                </sup>
                            </p>
                        </list-item>
                        <list-item>
                            <label>C)</label>
                            <p>Ultra smart textiles</p>
                            <p>The third generation of smart textiles, very smart textiles, have the capacity to perceive, react to, and change in response to outside stimuli. A very intelligent textile is essentially made up of a unit.
                                <sup>
                                    <xref ref-type="bibr" rid="ref14">14</xref>
                                </sup>
                            </p>
                        </list-item>
                    </list>
                </p>
                <p>It functions similarly to the brain and possesses cognitive, logical, and activating abilities. The creation of extremely smart textiles is now possible thanks to the successful fusion of traditional textile and apparel technology with other scientific fields like artificial intelligence, biology, advanced processing technology, communication, material science, structural mechanics, sensor and actuator technology and more.
                    <sup>
                        <xref ref-type="bibr" rid="ref15">15</xref>
                    </sup>
                </p>
                <p>
                    <bold>Analytical examples</bold>
                </p>
                <p>The aim of this section is to analyse in detail how previous researchers examined the nano materials performance in hospitals interior design. The example is chosen according to their proximity to the case study in terms of their location, scale and research techniques used. The selected examples were all designed by materials and technology used in Egypt. Therefore, the hospital had LEED certificate. The example presented varied between experimental usage of nano materials.</p>
            </sec>
            <sec id="sec20">
                <title>Selection criteria</title>
                <p>The reason for choosing the hospitals were based on the following specific criteria:
                    <list list-type="bullet">
                        <list-item>
                            <label>-</label>
                            <p>Nano materials used in the hospital provided in Egypt.</p>
                        </list-item>
                        <list-item>
                            <label>-</label>
                            <p>Location and scale approximately like the selected case study hospital and interior zones in the case study</p>
                        </list-item>
                        <list-item>
                            <label>-</label>
                            <p>LEED gold awarded for Nano materials (Joe DiMaggio Children&#x2019;s Hospital)</p>
                        </list-item>
                    </list>
                </p>
            </sec>
            <sec id="sec21">
                <title>Selected three examples</title>
                <p>In the following part the three international examples are explained in 
                    <xref ref-type="table" rid="T5">Table 5</xref> location, area, architect, hospital criteria to be selected and finally hospital description. 
                    <xref ref-type="table" rid="T6">Table 6</xref> shows the materials and coating types used in the selected areas.</p>
                <table-wrap id="T5" orientation="portrait" position="float">
                    <label>Table 5. </label>
                    <caption>
                        <title>Joe DiMaggio Children&#x2019;s Hospital,
                            <sup>
                                <xref ref-type="bibr" rid="ref10">10</xref>
                            </sup> Katz Women&#x2019;s Hospital,
                            <sup>
                                <xref ref-type="bibr" rid="ref10">10</xref>
                            </sup>
                            <sup>,</sup>
                            <sup>
                                <xref ref-type="bibr" rid="ref12">12</xref>
                            </sup> Lucile Packard Children&#x2019;s Hospital
                            <sup>
                                <xref ref-type="bibr" rid="ref16">16</xref>
                            </sup> description and criterias.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Hospital</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Location</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Area</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Architect</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Criteria</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Description</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="2" rowspan="1" valign="top">Hollywood</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">6000&#x2009;m
                                    <sup>2</sup>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Stanley Beaman &amp; Sears</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Hospital was awarded LEED for nano materials Gold Award</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">the hospital attained LEED&#x00ae; for New Construction Gold certification for energy use, lighting, water, and material use</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Katz Women&#x2019;s Hospital</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Manhasset, New york</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">9,128&#x2009;m
                                    <sup>2</sup>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">SOM</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">U.S. Green Building Council LEED CI v3
                                    <break/>&#x2212;Certified Platinum</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">U.S. Green Building Council LEED CI v3 Certified Platinum 10% of a Building Suburban Setting Substantial Completion March 2011</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Lucile Packard Children&#x2019;s Hospital</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Stanford</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">6000&#x2009;m
                                    <sup>2</sup>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Perkins+
                                    <break/>Will</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Platinum LEED certificate from the U.S. Green Building Council (USGBC).</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">The world's fifth new-build hospital to receive this award for sustainability excellence</td>
                            </tr>
                        </tbody>
                    </table>
                    <table-wrap-foot>
                        <p>SOM: Skidmore, Owings &amp; Merrill LLP architects.</p>
                    </table-wrap-foot>
                </table-wrap>
                <table-wrap id="T6" orientation="portrait" position="float">
                    <label>Table 6. </label>
                    <caption>
                        <title>Comparison table shows the difference between coatings, materials and properties between the three chosen hospitals by specific criteria.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Hospital</th>
                                <th align="left" colspan="2" rowspan="1" valign="top">Room element</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Coatings</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Materials</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Properties</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="19" valign="top">Joe DiMaggio Children&#x2019;s Hospital</td>
                                <td align="left" colspan="1" rowspan="10" valign="top">Patient room</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Floor finishing</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Photocatalytic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Ceramic-Marble</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Scratch resistance</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Walls finishing</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Paints</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Air purifying</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Window</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Aluminium</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Non-stick</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Furniture layout</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Wood</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-fungal</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Bedding+ cushion</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-microbial</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Cotton</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-fungal</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Carpet</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Air-purifying</td>
                                <td colspan="1" rowspan="1"/>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-microbial</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Light switches</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-microbial</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Plastic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Non-stick</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">W.C.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Photocatalytic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Ceramic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Show screens</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td colspan="1" rowspan="1"/>
                                <td align="left" colspan="1" rowspan="1" valign="top">Non-stick</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Doors</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Wood</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="9" valign="top">Surgery room</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Floor finishing</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Photocatalytic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Ceramic-Marble</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Scratch resistance</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Walls finishing</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Paints</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Air Purifying</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Window</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Aluminium</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Non-stick</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Bedding</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-microbial</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Cotton</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-fungal</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Furniture layout</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Aluminium</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-fungal</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Light Switches</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Air-purifying</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Low VOC vinyl</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-microbial</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">W.C.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-microbial</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Plastic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Non-stick</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Show screens</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Photocatalytic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Ceramic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Doors</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Wood</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Non-stick, Easy to clean</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="18" valign="top">Katz Women&#x2019;s Hospital</td>
                                <td align="left" colspan="1" rowspan="9" valign="top">Patient room</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Floor finishing</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Photocatalytic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Vinyl tile</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Scratch resistance</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Walls finishing</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">PVC</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Air purifying</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Window</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Stainless steel</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Non-stick</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Furniture layout</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Stainless steel</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-fungal</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Bedding+ cushion</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-microbial</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Cotton</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-fungal</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Carpet</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Air-purifying</td>
                                <td colspan="1" rowspan="1"/>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-microbial</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Light switches</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-microbial</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Plastic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Non-stick</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">W.C.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Photocatalytic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Ceramic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Doors</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Wood</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="9" valign="top">Surgery roomSurgery room</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Floor finishing</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Photocatalytic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Ceramic-Marble</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Scratch resistance</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Walls finishing</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Paints</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Air purifying</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Window</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Stainless steel</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Non-stick</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Bedding</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-microbial</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Polyester</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-fungal</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Furniture layout</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Aluminium</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-fungal</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Light switches</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Air-purifying</td>
                                <td colspan="1" rowspan="1"/>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-microbial</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">W.C.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-microbial</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Plastic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Non-stick</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Show screens</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Photocatalytic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Ceramic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Doors</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Wood</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Non-stick, Easy to clean</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="9" valign="top">Lucile Packard Children&#x2019;s Hospital</td>
                                <td align="left" colspan="1" rowspan="9" valign="top">Patient room</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Floor finishing</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Photocatalytic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">rubber</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Scratch resistance</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Walls finishing</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Plaster</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Air purifying</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Window</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Stainless steel</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Non-stick</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Furniture layout</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Plastic - plywood</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-Fungal</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Bedding+ cushion</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-microbial</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Polyester</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-Fungal</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Carpet</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Air-purifying</td>
                                <td colspan="1" rowspan="1"/>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-microbial</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Light switches</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-microbial</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Modern Plastic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Non-stick</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">W.C.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Photocatalic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Ceramic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Doors</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Wood</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                            </tr>
                            <tr>
                                <td colspan="1" rowspan="9"/>
                                <td align="left" colspan="1" rowspan="9" valign="top">Surgery room</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Floor finishing</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Photocatalic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Ceramic-Marble</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Scratch resistance</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Walls finishing</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Paints</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Air purifying</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Window</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Aluminium</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Non-stick</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Bedding</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-microbial</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Polyester - Nylon</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-fungal</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Furniture layout</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Aluminium</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-fungal</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Light switches</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Air-purifying</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Poly carbonate</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-microbial</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">W.C.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-microbial</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Plastic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Non-stick</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Show screens</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Photocatalic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Ceramic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Doors</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Wood</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Non-stick</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
            </sec>
            <sec id="sec22">
                <title>Example conclusion</title>
                <p>The most common and used nano coatings and materials used in the three hospitals and were able to obtain the LEED certificate by examining 
                    <xref ref-type="table" rid="T4">Tables 4</xref> and 
                    <xref ref-type="table" rid="T5">5</xref> and the previous example. As a result, the appropriate nanomaterials for operating rooms and patient rooms are listed in the following table (see 
                    <xref ref-type="table" rid="T7">Table 7</xref>).</p>
                <table-wrap id="T7" orientation="portrait" position="float">
                    <label>Table 7. </label>
                    <caption>
                        <title>The most common coatings examples which will be later applied in the selected case study according to the selected spaces.
                            <sup>
                                <xref ref-type="bibr" rid="ref4">4</xref>
                            </sup>
                        </title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Space type</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Space name</th>
                                <th align="left" colspan="4" rowspan="1" valign="top">Nano characteristics</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Coatings (Walls, ceiling and floors)</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Furniture and textile</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Insulation</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Highly sensitive areas</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Operating theatres</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Intensive Care Units</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Emergency ward</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Aseptic rooms</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Trauma rooms</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Surgical Washrooms</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="2" valign="top">Self-cleaning lotus effect</td>
                                <td align="left" colspan="1" rowspan="2" valign="top">Self-cleaning photocatalytic</td>
                                <td align="left" colspan="1" rowspan="2" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="2" valign="top">Antibacterial and antimicrobial
                                    <break/>effect</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Hygienic environment</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Defence against bacterial and germ sealment</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Robustness</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Immunity to contamination</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Dirt removal</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="2" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Various nano coatings applied to textiles, such as leather, cotton, wool, nylon, polyester, silk, and silk</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Coatings ought to include titanium dioxide, nano silver, copper, and gold particles.</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Avoid dust and dirt</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Preventing microbes from reproducing unintentionally and uncontrollably, which can pose a serious health risk when textiles are used.</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="2" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Insulation for walls, floors, and ceilings using PCMs and VIPs has the following features</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Very thin profile and tiny thickness</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Fits into extremely small and constrained spaces; performs exceptionally well as thermal insulation</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Can be applied to various areas of the space</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Aerogel's transparency makes it an ideal material for use in windows</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>It is also lightweight and highly effective on hydrophobic surfaces.</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Sensitive areas</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Pre-operative spaces</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Patient rooms</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Sterilizing room</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Laboratories</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Treatment rooms</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Functional diagnostics</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Sanitary areas</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Immune to microorganisms</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Adaptable to routine cleaning procedures</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Regulation of indoor climate</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
            </sec>
        </sec>
        <sec id="sec23">
            <title>Case study</title>
            <p>The aim of this section is to examine the concluded checklist from analytical examples of nano materials performance in interior design of hospitals in Alexandria, Egypt in terms of decreasing spread of disease and enhancing thermal comfort of the occupants. The chosen hospital is &#x201c;Elite Hospital&#x201d; (
                <xref ref-type="table" rid="T8">Table 8</xref>).</p>
            <table-wrap id="T8" orientation="portrait" position="float">
                <label>Table 8. </label>
                <caption>
                    <title>Elite Hospital description table.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Location</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Alexandria</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Area</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">6500&#x2009;m
                                <sup>2</sup>
                            </td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Description</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Accredited by the Egyptian Ministry of Health</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Number of floors</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">6</td>
                        </tr>
                    </tbody>
                </table>
            </table-wrap>
            <sec id="sec24">
                <title>&#x201c;Elite hospital&#x201d;</title>
                <p>
                    <italic toggle="yes">Project scope</italic>
                </p>
                <p>The &#x201c;Elite Hospital,&#x201d; a hospital facility accredited by the Egyptian Ministry of Health, is selected as the case study for this paper. In order to measure the finishing materials used in interior design, air temperature, and radiant temperature through simulations in DesignBuilder software version for the local case and after adding nano materials application.</p>
                <p>The &#x201c;Elite Hospital&#x201d; is situated eight kilometres down the Alexandria Mahmoudya desert road in Alexandria, Egypt. With an average maximum temperature for the day ranging from 19&#x00b0;C to 22&#x00b0;C in January and February are the coolest months in Alexandria&#x2019;s Mediterranean climate. The warmest months are July, August, and September, when the average daily maximum temperature is between 24&#x00b0;C and 27&#x00b0;C.
                    <sup>
                        <xref ref-type="bibr" rid="ref20">20</xref>
                    </sup>
                </p>
                <p>
                    <italic toggle="yes">Project design</italic>
                </p>
                <p>The hospital is separated into three sections as shown in 
                    <xref ref-type="fig" rid="f1">Figure 1</xref> that are connected by hallways.
                    <sup>
                        <xref ref-type="bibr" rid="ref20">20</xref>
                    </sup>
                </p>
                <fig fig-type="figure" id="f1" orientation="portrait" position="float">
                    <label>Figure 1. </label>
                    <caption>
                        <title>Elite Hospital plan.</title>
                        <p>Source: Plan edited by Author.</p>
                    </caption>
                    <graphic id="gr1" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/157244/20cef278-6452-493d-af36-e116422f739c_figure1.gif"/>
                </fig>
                <p>At an elite hospital, multidisciplinary care and patient wellness are key components of the standards of care that help keep patients in a healthy environment in the hospital. With that objective in mind, materials used in local healthcare in Egypt settings need to be assessed for their wider environmental effects in addition to their effects on the immediate patient environment.
                    <sup>
                        <xref ref-type="bibr" rid="ref20">20</xref>
                    </sup>
                    <sup>,</sup>
                    <sup>
                        <xref ref-type="bibr" rid="ref21">21</xref>
                    </sup>
                </p>
                <p>A sizable healthcare system has actually created a master standard program that specifies products to be used throughout the system and a uniform quality level. The emphasis on interior finishing materials was not given much weight when these standards were first developed, and the system&#x2019;s capacity to &#x201c;standardize&#x201d; healthier products was occasionally limited by the options and costs that could be chosen.
                    <sup>
                        <xref ref-type="bibr" rid="ref20">20</xref>
                    </sup>
                </p>
                <p>The Elite Hospital healthcare facility (as shown in 
                    <xref ref-type="fig" rid="f1">Figure 1</xref>), which uses cutting-edge materials like non-adhesive wall finishing materials and easily cleanable ceramic, is a superb example of modern Egyptian architecture. However, this combination led to a number of issues within the building, including heat gain and glare from the lack of environmentally friendly materials and the spread of illnesses, which accelerated the hospital&#x2019;s disease outbreak.
                    <sup>
                        <xref ref-type="bibr" rid="ref19">19</xref>
                    </sup> Furthermore, the interior finishes of the building, particularly the patient rooms, lack sustainable materials. All of these issues combined make for a challenging problem that needs careful research to guarantee safe, comfortable conditions with little chance of disease transmission on the building&#x2019;s interior surfaces (as shown in 
                    <xref ref-type="table" rid="T9">Table 9</xref>).</p>
                <table-wrap id="T9" orientation="portrait" position="float">
                    <label>Table 9. </label>
                    <caption>
                        <title>Hospital spaces classifications.
                            <sup>
                                <xref ref-type="bibr" rid="ref19">19</xref>
                            </sup>
                            <sup>&#x2013;</sup>
                            <sup>
                                <xref ref-type="bibr" rid="ref21">21</xref>
                            </sup>
                        </title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Zones classifications</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Areas</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Properties</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Highly sensitive areas</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Two Operating theatres</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>One Intensive Care Unit</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>One Emergency ward</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Surgical washrooms</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Trauma rooms</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>A requirement for hygiene</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Defence against the growth of bacteria and germs</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Material durability - Resistant to disinfectants</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Sensitive areas</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Rehab spaces - Prior to surgery</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Sanitising the space</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Clinics - Treatment areas</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Functional evaluations</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Patient rooms with clothes</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Area of utility and disposal</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>A requirement for hygiene</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Immune to microbes</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Able to withstand routine cleaning and mechanical loading</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Common area</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Waiting rooms</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Reception area</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Wards</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Care rooms</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Recreation rooms</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Be insensitive</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Washable</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Moist rooms</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Public washrooms</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Bathrooms</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Laundry</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Protection against mold</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Be water repellent</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Kitchen areas</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>Catering area</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Kitchen and food preparations</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Store rooms</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Cold store</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <p>
                                        <list list-type="bullet">
                                            <list-item>
                                                <label>-</label>
                                                <p>A hygienic setting</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Impervious to moisture, which can harbour bacteria and mould</p>
                                            </list-item>
                                            <list-item>
                                                <label>-</label>
                                                <p>Simple to maintain</p>
                                            </list-item>
                                        </list>
                                    </p>
                                </td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <p>
                    <italic toggle="yes">Selected space and possible solutions</italic>
                </p>
                <p>Based on the patient&#x2019;s most frequent area, choosing a standard patient room on the third typical floor on the South- west fa&#x00e7;ade, which was observed to experience thermal gain.</p>
                <p>For the purpose of comparative simulation, we propose the following changes to the patient room&#x2019;s interior finishes (as shown in 
                    <xref ref-type="fig" rid="f3">Figures 3</xref>, 
                    <xref ref-type="fig" rid="f4">4</xref> and 
                    <xref ref-type="fig" rid="f5">5</xref>) and the selected materials used as shown in 
                    <xref ref-type="table" rid="T10">Table 10</xref> and for the surgery room and the selected coatings and materials shown in 
                    <xref ref-type="table" rid="T11">Table 11</xref>:</p>
                <p>
                    <underline>A) Patient room</underline>
                </p>
                <table-wrap id="T10" orientation="portrait" position="float">
                    <label>Table 10. </label>
                    <caption>
                        <title>Finishing material table for a patient room before and after using nano materials.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Application</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Actual materials (Before)
                                    <sup>
                                        <xref ref-type="bibr" rid="ref20">20</xref>
                                    </sup>
                                </th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Nano effect</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Properties</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Fiber</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Nanoparticles (retrofit)</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Floor</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy clean ceramic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-bacterial</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Self-cleaning</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Ceramic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Nano ceramic tiles</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Wall paints</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Plastic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Air-purifying</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-bacterial</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Paint</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Titanium dioxide</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Window</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Glass</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Non-stick</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Glass</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Copper nano particles</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Doors</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Wood</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Self-cleaning</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Photocatalic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Wood</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Nanoparticle titanium dioxide</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Bedding</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Polyester</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-bacterial</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-fungal</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Cotton</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Gold nanoparticles</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Devices</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Plastic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-bacterial</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Enhanced scratch resistance</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Plastic and silver</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Silver nanoparticles chitosan</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Furniture wood</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">MDF</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-fungal</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Wood</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Nanoparticles of titanium dioxide</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Light</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Led</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Led &amp; OLED</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-bacterial</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Led</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Silicon oxide</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Window frame</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Aluminium</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Self-cleaning</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easly to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Aluminium</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Silicon oxide</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Showscreen</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Plastic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Non reflection</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Plastic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Silver
                                    <break/>Nanoparticles</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Door and window knobs</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Plastic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-bacterial</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Non-stick</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Knobs</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Nano aluminium oxide</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Light switches</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Plastic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-bacterial</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Non-stick</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Plastic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Silver nanoparticles
                                    <break/>Chitosan</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Carpet</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Wool</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Air-purifying</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Antimicrobial</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Cotton wool</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Nanoparticle titanium dioxide</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Upholstery</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Polyester</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Air-purifying</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Resistance</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Cotton</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Silver nanoparticles</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <p>
                    <underline>B) Surgery room</underline>
                </p>
                <table-wrap id="T11" orientation="portrait" position="float">
                    <label>Table 11. </label>
                    <caption>
                        <title>Finishing material table for a surgery room before and after using Nano materials.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Application</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Actual materials (before)
                                    <sup>
                                        <xref ref-type="bibr" rid="ref20">20</xref>
                                    </sup>
                                </th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Effect</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Properties</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Fiber</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Nanoparticles (retrofit)</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Floor</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy clean ceramic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-bacterial</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Self-cleaning</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Ceramic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Nano ceramic tiles</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Wall paints</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Plastic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Air-purifying</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-bacterial</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Paint</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Titanium dioxide</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Window</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Glass</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Non-stick</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Glass</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Copper nano particles</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Doors</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Wood</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Self-cleaning</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Photocatalic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Wood</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Nanoparticle titanium dioxide</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Bedding</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Polyester</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-bacterial</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-fungal</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Cotton</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Gold nanoparticles</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Devices</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Plastic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-bacterial</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Enhanced scratch resistance</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Plastic and silver</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Silver nanoparticles chitosan</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Furniture wood</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">MDF</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-fungal</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Wood</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Nanoparticles of titanium
                                    <break/>Dioxide</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Light</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Led</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Led &amp; OLED</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-bacterial</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Led</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Silicon oxide</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Window</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Aluminium</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Self-cleaning</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easly to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Aluminium</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Silicon oxide</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Showscreen</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Plastic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Easy to clean</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Non reflection</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Plastic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Silver
                                    <break/>Nanoparticles</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Door and window knobs</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Plastic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-bacterial</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Non-stick</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Knobs</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Nano aluminium oxide</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Light switches</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Plastic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Anti-bacterial</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Non-stick</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Plastic</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Silver nanoparticles
                                    <break/>Chitosan</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Carpet</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Wool</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Air-purifying</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Antimicrobial</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Cotton wool</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Nanoparticle titanium dioxide</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Upholstery</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Polyester</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Air-purifying</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Resistance</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Cotton
                                    <break/>Nylon
                                    <break/>Polyester
                                    <break/>Silk</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Silver nanoparticles</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
            </sec>
            <sec id="sec25">
                <title>Case study simulations and their subsequent implementation</title>
                <p>The hospital patient room base case and the post-implementation results with Nano materials used in a patient&#x2019;s room interior finishing are contrasted in the following analysis diagrams. Identifying how materials affect the results of thermal comfort effect simulations.</p>
                <p>The three-dimension simulation for air temperature comparison chart (shown in 
                    <xref ref-type="fig" rid="f2">Figure 2</xref>) is the baseline, and (shown in the 
                    <xref ref-type="fig" rid="f3">Figures 3</xref>, 
                    <xref ref-type="fig" rid="f4">4</xref> and 
                    <xref ref-type="fig" rid="f5">5</xref>) is the post-implementation. The 
                    <xref ref-type="fig" rid="f2">Figures 2</xref> and 
                    <xref ref-type="fig" rid="f3">3</xref>, 
                    <xref ref-type="fig" rid="f4">4</xref> and 
                    <xref ref-type="fig" rid="f5">5</xref> were obtained from the author&#x2019;s work on the &#x201c;Elite Hospital&#x201d; patient room using Design Builder program.</p>
                <fig fig-type="figure" id="f2" orientation="portrait" position="float">
                    <label>Figure 2. </label>
                    <caption>
                        <title>Base case: shows the monthly simulation results for the chosen patient room&#x2019;s air temperatures, radiant temperature, and relative humidity from January 1 to December 31, (2) Base case.</title>
                        <p>While working on the &#x201c;Elite Hospital&#x201d; patient room, the researcher took the 
                            <xref ref-type="fig" rid="f2">Figures 2</xref>, 
                            <xref ref-type="fig" rid="f3">3</xref>, 
                            <xref ref-type="fig" rid="f4">4</xref> and 
                            <xref ref-type="fig" rid="f5">5</xref>. the author used the computer programme &#x201c;DesignBuilder&#x201d; for simulation changes to the patient room space.</p>
                    </caption>
                    <graphic id="gr2" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/157244/20cef278-6452-493d-af36-e116422f739c_figure2.gif"/>
                </fig>
                <fig fig-type="figure" id="f3" orientation="portrait" position="float">
                    <label>Figure 3. </label>
                    <caption>
                        <title>Post-implementation case: using ceramic with nano properties, Monthly results for Temperatures, heat gains of the specified patient room that contribute to disease spread from 1 January to 31 December (3) Base case.</title>
                        <p>The 
                            <xref ref-type="fig" rid="f2">Figures 2</xref>, 
                            <xref ref-type="fig" rid="f3">3</xref>, 
                            <xref ref-type="fig" rid="f4">4</xref> and 
                            <xref ref-type="fig" rid="f5">5</xref> were taken during the researcher's work on the &#x201c;Elite Hospital&#x201d; patient room, used the computer software "Design Builder" to simulate alterations to the area.</p>
                    </caption>
                    <graphic id="gr3" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/157244/20cef278-6452-493d-af36-e116422f739c_figure3.gif"/>
                </fig>
                <fig fig-type="figure" id="f4" orientation="portrait" position="float">
                    <label>Figure 4. </label>
                    <caption>
                        <title>Post-implementation case: using epoxy with nano properties, N simulation monthly results for Temperatures, heat gains of the selected patient room which led to disease spread from 1 January to 31 December (4) Base case.</title>
                        <p>The 
                            <xref ref-type="fig" rid="f2">Figures 2</xref>, 
                            <xref ref-type="fig" rid="f3">3</xref>, 
                            <xref ref-type="fig" rid="f4">4</xref> and 
                            <xref ref-type="fig" rid="f5">5</xref> were taken during the researcher's work on the &#x201c;Elite Hospital&#x201d; patient room, where the author used the computer software &#x201c;Design Builder&#x201d; to simulate alterations to the area.</p>
                    </caption>
                    <graphic id="gr4" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/157244/20cef278-6452-493d-af36-e116422f739c_figure4.gif"/>
                </fig>
                <fig fig-type="figure" id="f5" orientation="portrait" position="float">
                    <label>Figure 5. </label>
                    <caption>
                        <title>Post-implementation case: using marble with nano properties, Nano Marble was utilised in the patient room simulation to produce monthly data for temperatures and heat gains in the selected patient room, resulting in disease spread from 1 January to 31 December (5) Base case.</title>
                        <p>The 
                            <xref ref-type="fig" rid="f2">Figures 2</xref>, 
                            <xref ref-type="fig" rid="f3">3</xref>, 
                            <xref ref-type="fig" rid="f4">4</xref> and 
                            <xref ref-type="fig" rid="f5">5</xref> were taken during the researcher's work on the &#x201c;Elite Hospital&#x201d; patient room, where the author used the computer software &#x201c;Design Builder&#x201d; to simulate alterations to the area.</p>
                    </caption>
                    <graphic id="gr5" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/157244/20cef278-6452-493d-af36-e116422f739c_figure5.gif"/>
                </fig>
                <p>The addition of Nano material to the building&#x2019;s interior finishing and the installation of walls, as per the air temperature analysis, led to more evenly distributed colder temperatures, improving thermal comfort and limiting the spread of disease. The average temperature for the user area in 
                    <xref ref-type="fig" rid="f1">Figure 1</xref>, which depicts the three-dimensional thermal distribution in the basic case patient room to cover less space, is between 19.05 &#x00b0;C and 19.21&#x00b0;C (coloured blue, yellow, light green, and green). On the other hand, the 
                    <xref ref-type="fig" rid="f3">Figures 3</xref>, 
                    <xref ref-type="fig" rid="f4">4</xref> and 
                    <xref ref-type="fig" rid="f5">5</xref> shows the 3D temperature distribution after the patient room&#x2019;s temperature rises as a result of the addition of nanomaterials to the floor and wall finishes. When compared to the useful zone temperature data, which range from 18.92&#x00b0;C to 18.05&#x00b0;C (colour indication: cyan, green, and light green), the blue zone colouring has faded, indicating. a temperature. zone of 19.33&#x00b0;C. The average temperature decreased by 1.16&#x00b0;C as a result, an improvement of 7%.</p>
                <p>The air temperature decreased by 4.3% in January, 5.2% in February, 6.1% in March, 4.4% in April, 3.1% in May, 2.6% in June, 2.5% in July, 2.4% in August, 3.6% in September, 4.3% in October, 5.8% in November, and 4.5% in December (according to 
                    <xref ref-type="fig" rid="f3">Figures 3</xref>, 
                    <xref ref-type="fig" rid="f4">4</xref>, and 
                    <xref ref-type="fig" rid="f5">5</xref>).</p>
                <p>January through December saw reductions in relative humidity of 34.5 %, 34.1%, 33.9 %, 30.5%, 24.3%, 20.2%, July, and August by 22.1%, 27.9 percent, 33.4 percent, September, October, and November by 35.6 percent, and December by 34.3 % (as shown in to 
                    <xref ref-type="fig" rid="f3">Figures 3</xref>, 
                    <xref ref-type="fig" rid="f4">4</xref>, and 
                    <xref ref-type="fig" rid="f5">5</xref>).</p>
                <p>Air temperature, radiant temperature, and relative humidity were all reduced by 7% in January, 6.5% in February, 6% in March, 6% in April, 3% in May, 4% in June, 7% in July, 1.7% in August, 1.8% in September, 2% in October, 3.4% in November, and 8.3% in December (see 
                    <xref ref-type="fig" rid="f3">Figures 3</xref>, 
                    <xref ref-type="fig" rid="f4">4</xref>, 
                    <xref ref-type="fig" rid="f5">5</xref> and 
                    <xref ref-type="fig" rid="f6">6</xref>).</p>
                <fig fig-type="figure" id="f6" orientation="portrait" position="float">
                    <label>Figure 6. </label>
                    <caption>
                        <title>Air Temperatures, radiant temperature, and relative humidity of the selected patient room from first of January to thirty-one of December (2) Base case, (3) (4) (5) using different criteria on nano materials.</title>
                        <p>The 
                            <xref ref-type="fig" rid="f2">Figures 2</xref>, 
                            <xref ref-type="fig" rid="f3">3</xref>, 
                            <xref ref-type="fig" rid="f4">4</xref> and 
                            <xref ref-type="fig" rid="f5">5</xref> were taken during the researcher's work on the &#x201c;Elite Hospital&#x201d; patient room, where she used the computer software &#x201c;Design Builder&#x201d; to model modifications in the patient room area.</p>
                    </caption>
                    <graphic id="gr6" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/157244/20cef278-6452-493d-af36-e116422f739c_figure6.gif"/>
                </fig>
                <p>In addition, in numbers, nano materials have proven their ability in hospitals to reduce temperature and provide a healthy environment for patients. The most applicable materials used to prevent the spread of bacteria and epidemics on the hospital&#x2019;s interior surfaces are nano-modified materials, better than the traditional materials used in most hospitals.</p>
            </sec>
        </sec>
        <sec id="sec26">
            <title>Conclusions and recommendations</title>
            <sec id="sec27">
                <title>Case study results and conclusion</title>
                <p>The models demonstrate that.by utilizing nano materials in Egyptian hospitals to floors and walls coverings by using DesignBuilder on the selected patient room of the case study, the air temperature was decrease after using nano materials by an average of 12.3-16.7% throughout the year, radiant temperature decreased by 3-4.2% and relative humidity decreased by 7-12% through the year when it is designed by nano materials on walls and floors coverings to the room materials so reduce of bacterial infection in the room. Lastly, adding one of the recommended nano materials to walls and floors enhanced the transfer of bacteria on surfaces by air distribution, and air temperature. Direct contact of the viruses and bacteria to the surface of nano material reduce 18% than basic material used in hospitals.</p>
            </sec>
            <sec id="sec28">
                <title>Research conclusion and recommendation</title>
                <p>Nanotechnology is generating hygienic items without endangering the environment or human health. Additionally, it is regarded as the answer to environmental issues, particularly those that relate to structural issues. The study&#x2019;s main goal was to examine the effects of nanotechnology applications on the environment inside of the building. By utilizing nanotechnology, healthcare facilities may be kept in the highest possible quality and efficiency thanks to the use of nanoparticles that make them more durable, environmentally friendly, and long-term damage resistant.</p>
                <p>Then because of the properties of these materials, maintenance costs are minimized. Therefore, applications of nanotechnology are seen as a revitalization and upgrade process for the building to protect it against various bacterial, tearing, and damage factors that affect the building&#x2019;s performance inside or outside.</p>
                <p>The study advises designers and architects to select finishing materials using the most recent techniques, especially for healthcare and medical buildings, to keep them as safe as possible over time and prevent any flaws from developing and endangering them. Like in all industrialized countries, because it helps to increase the efficiency of healthcare buildings, applying nanotechnology techniques to the interior finishing materials specially in healthcare and medical facility designs in Egypt is essential.</p>
                <p>The ability. to work. from. the &#x201c;bottom&#x201d; of material design to the &#x201c;top&#x201d; of the constructed environment is provided by nanotechnology, which is the antithesis of the conventional top-down approach to construction&#x2014;or, for that matter, any production technique. The new properties of nanomaterials in hospital interior finishes have an impact on people&#x2019;s lives, the environment, and the economy by helping to achieve sustainability and biological properties (biological materials in terms of functional form).</p>
                <p>Lastly, nanomaterials will lead to lighter, smaller and more durable buildings, and more sustainable interior finishes, reducing construction costs and preserving Flat Earth for generations to come. In addition, it will protect the topography of mountains, plains, and forests, as well as other natural resources that support the idea of sustainability.</p>
            </sec>
        </sec>
    </body>
    <back>
        <sec id="sec31" sec-type="data-availability">
            <title>Data availability</title>
            <sec id="sec32">
                <title>Underlying data</title>
                <p>Mendeley data: SABE Simulation. 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.17632/xgtg6kvr2g.2">https://doi.org/10.17632/xgtg6kvr2g.2</ext-link>.
                    <sup>

                        <xref ref-type="bibr" rid="ref20">20</xref>
</sup>
                </p>
                <p>This project contains the following underlying data:
                    <list list-type="bullet">
                        <list-item>
                            <label>-</label>
                            <p>Elite hospital plan. JPG (a cross-section and detailed architectural plan for the Elite Hospital building)</p>
                        </list-item>
                        <list-item>
                            <label>-</label>
                            <p>case study 01. jpg (A three-dimensional model for the base case and the criteria that are implemented after the fact for the patient room case study)</p>
                        </list-item>
                        <list-item>
                            <label>-</label>
                            <p>case study 014. JPG (the HVAC used in the selected space, the fan cool unit and air cooled chiller)</p>
                        </list-item>
                        <list-item>
                            <label>-</label>
                            <p>case study013.JPG (this is the annual heating and cooling in the room selected for the case study)</p>
                        </list-item>
                        <list-item>
                            <label>-</label>
                            <p>case study01 2.JPG (this is the construction template with wall materials used in details and floors materials used)</p>
                        </list-item>
                        <list-item>
                            <label>-</label>
                            <p>case study 011. JPG (opening details glazing type used, dimensions and window spacing)</p>
                        </list-item>
                    </list>
                </p>
                <p>Data are available under the terms of the 
                    <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International license</ext-link> (CC-BY 4.0).</p>
            </sec>
            <sec id="sec33">
                <title>Extended data</title>
                <p>Analysis code available from: 
                    <ext-link ext-link-type="uri" xlink:href="https://github.com/TokaEhab1995/Nanothecnology-in-Interior-Design-of-hospitals/tree/v1">https://github.com/TokaEhab1995/Nanothecnology-in-Interior-Design-of-hospitals/tree/v1</ext-link>
                </p>
                <p>Archived analysis code at time of publication: 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.5281/zenodo.10703554">https://doi.org/10.5281/zenodo.10703554</ext-link>.
                    <sup>

                        <xref ref-type="bibr" rid="ref21">21</xref>
</sup>
                </p>
                <p>License: CC-BY 4.0</p>
            </sec>
        </sec>
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