<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN" "http://jats.nlm.nih.gov/publishing/1.2/JATS-journalpublishing1.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="research-article" dtd-version="1.2" xml:lang="en">
    <front>
        <journal-meta>
            <journal-id journal-id-type="pmc">F1000Research</journal-id>
            <journal-title-group>
                <journal-title>F1000Research</journal-title>
            </journal-title-group>
            <issn pub-type="epub">2046-1402</issn>
            <publisher>
                <publisher-name>F1000 Research Limited</publisher-name>
                <publisher-loc>London, UK</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="doi">10.12688/f1000research.152778.2</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Research Article</subject>
                </subj-group>
                <subj-group>
                    <subject>Articles</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Smartphone dependence and addiction and bruxism in &#x201c;NEET&#x201d; young people in two coastal cities in Peru</article-title>
                <fn-group content-type="pub-status">
                    <fn>
                        <p>[version 2; peer review: 1 not approved]</p>
                    </fn>
                </fn-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Yarlequ&#x00e9; Mendoza</surname>
                        <given-names>Silvana Jackeline</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Project Administration</role>
                    <role content-type="http://credit.niso.org/">Resources</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Zambrano Uceda</surname>
                        <given-names>Katerine Estefani</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Project Administration</role>
                    <role content-type="http://credit.niso.org/">Resources</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="yes">
                    <name>
                        <surname>Orrego-Ferreyros</surname>
                        <given-names>Luis Alexander</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Project Administration</role>
                    <role content-type="http://credit.niso.org/">Software</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="corresp" rid="c1">a</xref>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <aff id="a1">
                    <label>1</label>Facultad de Ciencias de la Salud, Escuela de Estomatolog&#x00ed;a, Universidad Cesar Vallejo, Piura, Piura, 20001, Peru</aff>
            </contrib-group>
            <author-notes>
                <corresp id="c1">
                    <label>a</label>
                    <email xlink:href="mailto:laorrego@ucvvirtual.edu.pe">laorrego@ucvvirtual.edu.pe</email>
                </corresp>
                <fn fn-type="conflict">
                    <p>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>6</day>
                <month>7</month>
                <year>2026</year>
            </pub-date>
            <pub-date pub-type="collection">
                <year>2024</year>
            </pub-date>
            <volume>13</volume>
            <elocation-id>861</elocation-id>
            <history>
                <date date-type="accepted">
                    <day>17</day>
                    <month>6</month>
                    <year>2026</year>
                </date>
            </history>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2026 Yarlequ&#x00e9; Mendoza SJ et al.</copyright-statement>
                <copyright-year>2026</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <self-uri content-type="pdf" xlink:href="https://f1000research.com/articles/13-861/pdf"/>
            <abstract>
                <sec>
                    <title>Background</title>
                    <p>Excessive smartphone use has become a growing public health concern, especially among young people. Previous studies have suggested a possible relationship between excessive smartphone use and bruxism. However, the evidence on this relationship is still limited and inconclusive. This study aimed to determine the relationship between smartphone dependence and addiction and bruxism in &#x201c;NEET&#x201d; (not in education, employment or training) young people in two coastal cities in Peru: Piura and Chincha.</p>
                </sec>
                <sec>
                    <title>Methods</title>
                    <p>A cross-sectional, correlational, and exploratory study was conducted. The sample consisted of 195 "NEETs" young people who attended to dental office. Two data collection instruments were used: the Smartphone Dependence and Addiction Scale (EDAS-18) and the self-reported bruxism questionnaire (CBA). The Chi2 Pearson test was used to analyze the association between the variables.</p>
                </sec>
                <sec>
                    <title>Results</title>
                    <p>In Piura, a significant association was found between smartphone dependence or addiction and bruxism (49.3% of young people with smartphone dependence or addiction had bruxism, p-value = 0.003). However, in Chincha this relationship was not significant. In the latter city, bruxism showed a significant association with gender (men had a higher prevalence of bruxism, p-value = 0.034), but not with smartphone dependence or addiction (p-value = 0.171). In Piura, the proportion of bruxism was 3.77 times higher in those with smartphone dependence or addiction in the simple model (p-value = 0.004), and 5.38 times higher in the adjusted model (p-value = 0.001).</p>
                </sec>
                <sec>
                    <title>Conclusion</title>
                    <p>This study highlights the regional variability in the relationship between smartphone use and bruxism among &#x201c;NEETs&#x201d; young people. A significant association is evident in Piura but not in Chincha, which underscores the need for context-adapted interventions to address the effects of excessive technology use on oral health.</p>
                </sec>
            </abstract>
            <kwd-group kwd-group-type="author">
                <kwd>Internet Addiction Disorder</kwd>
                <kwd>Bruxism</kwd>
                <kwd>Young Adult</kwd>
                <kwd>Unemployment</kwd>
                <kwd>NEET</kwd>
            </kwd-group>
            <funding-group>
                <funding-statement>The author(s) declared that no grants were involved in supporting this work.</funding-statement>
            </funding-group>
        </article-meta>
        <notes>
            <sec sec-type="version-changes">
                <label>Revised</label>
                <title>Amendments from Version 1</title>
                <p>In response to peer review, this version (V2) strengthens the manuscript without altering the underlying data, the analyses, or the reported results. The Introduction now develops two complementary hypotheses that may link smartphone dependence and addiction to bruxism: a biomechanical-postural pathway, in which sustained forward head posture increases masticatory-muscle load, and a psychosocial-behavioural pathway, in which dependence is associated with stress, anxiety and sleep disturbance. We have also added a paragraph on the contextual variability of bruxism across populations, which motivates the comparison between Piura and Chincha, and we now state explicit hypotheses. In the Methods, we clarify that the 15&#x2013;29 age range corresponds to the operational definition of NEET youth, describe how the sample size was determined using a finite-population proportion formula and its assumptions, and state explicitly that daily hours of smartphone use and other predisposing factors of bruxism (sleep, anxiety/stress, swallowing problems) were not recorded. The Statistical analysis section harmonises the reporting terminology and acknowledges the exploratory, hypothesis-generating nature of the study, with no a priori power analysis and no correction for multiple comparisons. The Discussion now offers literature-grounded interpretations of the regional difference and of the sex&#x2013;bruxism finding, reframes the language from causal to associative, and substantially expands the limitations. Three new references were added.</p>
            </sec>
        </notes>
    </front>
    <body>
        <sec id="sec5" sec-type="intro">
            <title>Introduction</title>
            <p>Smartphones were introduced to the market in 2007 and have since become an indispensable part of life for millions of people worldwide.
                <sup>
                    <xref ref-type="bibr" rid="ref1">1</xref>
                </sup> By 2021, the GSM Association of the Global System for Mobile Communications reported that 75% of people in the world owned a smartphone.
                <sup>
                    <xref ref-type="bibr" rid="ref2">2</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref3">3</xref>
                </sup> According to the National Institute of Statistics and Informatics (INEI), in the first three months of 2023, 89.2% of people aged 6 and over in the country had access to the Internet from a cell phone; this figure exceeds by 7.8% that obtained in 2019.
                <sup>
                    <xref ref-type="bibr" rid="ref4">4</xref>
                </sup> This increase can be justified by its multiple functions such as facilitating communication, vast access to information; it also fulfills the function of a computer, a camera, an entertainment game, a multimedia player and provides access to e-books and thousands of entertainments, education and social interaction applications.
                <sup>
                    <xref ref-type="bibr" rid="ref5">5</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref6">6</xref>
                </sup>
            </p>
            <p>On the other hand, because of the Covid-19 pandemic and the lockdown, changes in lifestyle were generated,
                <sup>
                    <xref ref-type="bibr" rid="ref7">7</xref>
                </sup> so that it was necessary to adapt to virtuality. Also, the figures of young people who are not in education, employment, or training (NEETs) increased, who before the pandemic represented 16.73% of the young population and became 26.82%, this represents a great barrier that limits economic growth and development in the country.
                <sup>
                    <xref ref-type="bibr" rid="ref8">8</xref>
                </sup>
            </p>
            <p>The term addiction can be defined as a pathological behavioral condition in which one cannot think or judge rationally due to certain ideas or objects,
                <sup>
                    <xref ref-type="bibr" rid="ref9">9</xref>
                </sup> this addiction leads to a lack of ability to properly manage actions that can have harmful results.
                <sup>
                    <xref ref-type="bibr" rid="ref7">7</xref>
                </sup>
            </p>
            <p>Considering the negative impact that smartphone addiction has, it is thought that it is a conditioning factor for the appearance and development of different disorders such as bruxism, which is a condition that consists of a repetitive pattern of the masticatory muscles characterized by clenching and grinding the teeth.
                <sup>
                    <xref ref-type="bibr" rid="ref10">10</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref11">11</xref>
                </sup>
            </p>
            <p>Two complementary, non-mutually exclusive pathways have been proposed to explain how excessive smartphone use might favour bruxism. The first is biomechanical-postural: prolonged neck flexion to look at the screen promotes a sustained forward head posture, which alters the resting position of the mandible, reduces the craniovertebral angle and increases the load on the cervical and masticatory muscles, generating chronic hyperactivity of the masseter and temporalis that is shared with bruxism and temporomandibular disorders.
                <sup>
                    <xref ref-type="bibr" rid="ref27">12</xref>
                </sup> Consistent with this, electromyographic studies in heavy smartphone users have documented increased fatigue and altered resting activity of the masticatory muscles after device use.
                <sup>
                    <xref ref-type="bibr" rid="ref28">13</xref>
                </sup> The second pathway is psychosocial-behavioural: smartphone dependence and addiction are associated with stress, anxiety and sleep disturbances, and these psychological factors are, within the biopsychosocial model, among the most consistently reported predisposing factors for bruxism.
                <sup>
                    <xref ref-type="bibr" rid="ref29">14</xref>
                </sup> Excessive device use may therefore act on bruxism both directly, through muscular overload, and indirectly, by amplifying psychological distress and disrupting sleep.</p>
            <p>The expression of bruxism varies considerably between populations and settings. Reported prevalences differ widely across studies, reflecting not only methodological and diagnostic heterogeneity but also differences in psychosocial stressors, lifestyle and socioeconomic context.
                <sup>
                    <xref ref-type="bibr" rid="ref29">14</xref>
                </sup> This contextual variability justifies examining the smartphone&#x2013;bruxism relationship in more than one geographical setting rather than assuming a uniform effect, and it is one reason why two coastal cities with different demographic and care-seeking profiles (Piura and Chincha) were compared in the present study.</p>
            <p>Accordingly, the aim of this study was to determine the association between smartphone dependence and addiction and bruxism in NEET young people in two coastal cities in Peru, Piura and Chincha. We hypothesised that (i) smartphone dependence or addiction would be positively associated with the presence of bruxism symptoms, and (ii) that the strength of this association could differ between the two cities given their distinct sociodemographic and contextual characteristics. Given its exploratory design, the study was intended to be hypothesis-generating rather than confirmatory.</p>
        </sec>
        <sec id="sec6" sec-type="methods">
            <title>Methods</title>
            <sec id="sec7">
                <title>Type and design study</title>
                <p>The research was cross-sectional, correlational, and has exploratory design. Our study has adhered to the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) guidelines for cross-sectional studies. The study was approved with Official Letter from the Research Ethics Committee of the School of Stomatology N&#x00b0; 0109-2023-/UCV/P dated December 20, 2023. We adhered to the principles of the Declaration of Helsinki.</p>
            </sec>
            <sec id="sec8">
                <title>Participants</title>
                <p>The population consisted of 200 patients from the &#x201c;Odontofamily&#x201d; dental office in Chincha and 600 patients from the dental department at the &#x201c;Catacaos Maternal and Child Center&#x201d; in Piura, from late December 2023 to January 2024. Applying a non-probabilistic convenience sampling for a finite population, a sample of 82 people was established for Chincha and 113 for Piura. The sample size was calculated using the formula for estimating a proportion in a finite population, assuming an expected proportion of 50% (the value that maximises variance, as no prior local estimate was available), a 95% confidence level and an absolute margin of error of approximately 8%; applied to the source populations of 200 (Chincha) and 600 (Piura) patients, this yielded the target sizes of 82 and 113, respectively. The 15&#x2013;29 age range was not arbitrary: it corresponds to the operational definition of NEET youth (young people not in education, employment or training) used by INEI and by international bodies, so the age window was determined by the study population rather than chosen post hoc. No formal a priori power analysis was performed for the association tests, consistent with the exploratory, hypothesis-generating purpose of the study; this is acknowledged as a limitation. The inclusion criteria for the study were: patients of both sexes, between 15 and 29 years old who attended to dental office and the Maternal and Child Center in Chincha and Piura from late December 2023 to January 2024, who were able to sign the written informed consent or informed assent and who did not have any of these three statuses: employed, student or in training. The exclusion criterion was patients with any mental disability or incapacity that prevents them from giving their consent to participate in the study.</p>
            </sec>
            <sec id="sec9">
                <title>Instrument and procedures</title>
                <p>The two variables studied were &#x201c;smartphone dependence and addiction&#x201d; and &#x201c;bruxism&#x201d;. Two questionnaires were used as data collection instruments, the first is the Smartphone Dependence and Addiction Scale (EDAS-18), which consists of 18 items and proposes three levels of intensity: without dependence (18-37 points), dependence (38-64 points) and addiction (65-90 points).
                    <sup>
                        <xref ref-type="bibr" rid="ref12">15</xref>
                    </sup> For the evaluation of bruxism, the self-reported bruxism questionnaire (CBA) was used, which consists of 11 questions. Where a score of 0 to 18 indicates improbable bruxism, 19 to 24 indicates probable symptoms of bruxism and 25 or more indicates definite symptoms of bruxism.
                    <sup>
                        <xref ref-type="bibr" rid="ref13">16</xref>
                    </sup> It should be noted that the EDAS-18 captures the intensity of dependence and addiction through its 18 items and total score, rather than the raw number of hours of daily smartphone use; therefore, self-reported daily usage time was not recorded as a separate continuous variable and no cut-off (for example, 4 hours/day) was applied to define &#x201c;heavy&#x201d; use. Likewise, other recognised predisposing factors for bruxism&#x2014;such as sleep disorders, anxiety or other psychogenic factors, and swallowing problems&#x2014;were not measured in this study. These choices are addressed in the limitations and in the recommendations for future research.</p>
            </sec>
            <sec id="sec10">
                <title>Statistical analysis</title>
                <p>As for the statistical analysis of the data, an Excel spreadsheet created with 
                    <ext-link ext-link-type="uri" xlink:href="https://www.google.com/intl/es/sheets/about/">Google Sheets</ext-link> was used to store the data. Then they were examined using 
                    <ext-link ext-link-type="uri" xlink:href="https://jasp-stats.org/">JASP</ext-link> 0.18.3. For descriptive statistics, a descriptive table was made with the demographic characteristics, the frequency of bruxism and smartphone dependence or addiction. In addition, scatterplot was created to visually display the scores obtained.</p>
                <p>To evaluate the relationship between &#x201c;smartphone dependence and addiction&#x201d; and &#x201c;bruxism&#x201d;, the Pearson&#x2019;s Chi-square (&#x03c7;
                    <sup>2</sup>) test was used. The magnitude of the association between bruxism and smartphone dependence or addiction was estimated through regression and expressed as the ratio of bruxism proportions (PR) with its 95% confidence interval, as reported in 
                    <xref ref-type="table" rid="T3">
Table 3</xref>. A simple (unadjusted) model and an adjusted model incorporating the sex and age-group variables were fitted. The analysis was carried out with a confidence level of 95% (p&lt;0.05). Because the study was exploratory and analyses were stratified by city, several association tests were performed; no correction for multiple comparisons was applied and no a priori power analysis was conducted for these tests, so the results&#x2014;particularly within the smaller subgroups&#x2014;should be interpreted as hypothesis-generating.</p>
            </sec>
        </sec>
        <sec id="sec11" sec-type="results">
            <title>Results</title>
            <p>
                <xref ref-type="table" rid="T1">
Table 1</xref> shows that in the city of Chincha, the distribution by sex of young &#x201c;NEETs&#x201d; is similar. The group between 25 and 29 years of age stands out with 41.4%. Regarding bruxism, 56.8% are considered to have improbable symptoms, while 22.2% present probable symptoms, and 20.1% show definite symptoms. Regarding smartphone dependence or addiction, a significant 63.4% show dependence, and 2.4% show addiction.</p>
            <table-wrap id="T1" orientation="portrait" position="float">
                <label>
Table 1. </label>
                <caption>
                    <title>Sociodemographic characteristics of &#x201c;NEET&#x201d; young people in two coastal cities in Peru.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1" valign="top">City</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">
n (%)</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Chincha</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;Sex</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;Female</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">41 (50.0)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;Male</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">41 (50.0)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;Age (years)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;15 to 19</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">17 (20.7)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;20 to 24</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">31 (37.8)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;25 to 29</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">34 (41.4)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;Bruxism</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;Unlikely bruxism</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">46 (56.8)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;Probable symptoms of bruxism</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">18 (22.2)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;Definite symptoms of bruxism</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">17 (20.1)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="2" rowspan="1" valign="middle">&#x2003;&#x2003;Smartphone dependence or addiction</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;No dependence or addiction</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">28 (34.1)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;Dependence</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">52 (63.4)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;Addiction</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">2 (2.4)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Piura</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;Sex</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;Female</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">87 (77.0)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;Male</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">26 (23.0)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;Age (years)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;15 to 19</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">29 (25.7)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;20 to 24</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">36 (31.9)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;25 to 29</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">48 (42.5)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;Bruxism</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;Unlikely bruxism</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">68 (60.7)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;Probable symptoms of bruxism</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">21 (18.7)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;Definite symptoms of bruxism</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">23 (20.5)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="2" rowspan="1" valign="middle">&#x2003;&#x2003;Smartphone dependence or addiction</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;No dependence or addiction</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">39 (34.5)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;Dependence</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">70 (61.9)</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;Addiction</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">4 (3.5)</td>
                        </tr>
                    </tbody>
                </table>
            </table-wrap>
            <p>On the other hand, in Piura, a higher proportion of female participants (77.0%) is observed. The 25-29 age group also stands out with 42.5%. Regarding bruxism, 60.7% report unlikely symptoms, while 18.7% have probable symptoms and 20.5% present definite symptoms. Smartphone dependence or addiction is also notable, with 61.9% showing dependence and 3.5% addiction.</p>
            <p>
                <xref ref-type="table" rid="T2">
Table 2</xref> shows that in Chincha, sex presents a significant association with bruxism, with a p-value of 0.034, where men present higher prevalence (55.0%) of probable or definitive bruxism. However, age and smartphone dependence or addiction did not show statistically significant differences.</p>
            <table-wrap id="T2" orientation="portrait" position="float">
                <label>
Table 2. </label>
                <caption>
                    <title>Factors related to bruxism in &#x201c;NEET&#x201d; young people in two coastal cities in Peru.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="2" valign="bottom">City</th>
                            <th align="left" colspan="2" rowspan="1" valign="top">Bruxism</th>
                            <th align="left" colspan="1" rowspan="2" valign="bottom">p-value
</th>
                        </tr>
                        <tr>
                            <th align="left" colspan="1" rowspan="1" valign="top">Unlikely bruxism</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">
Probable symptoms of bruxism or definite symptoms of bruxism</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Chincha</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;Sex</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.034
                                <sup>
                                    <xref ref-type="table-fn" rid="tfn1">*</xref>
                                </sup>
                            </td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;Female</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">28 (69.3)</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">13 (31.7)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;Male</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">18 (45.0)</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">22 (55.0)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;Age</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">(years)</td>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.195</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2003;&#x2003;&#x2003;15 to 19</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">7 (41.2)</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">10 (58.8)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2003;&#x2003;&#x2003;20 to 24</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">21 (67.7)</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">10 (32.3)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2003;&#x2003;&#x2003;25 to 29</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">18 (54.5)</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">15 (45.4)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="2" rowspan="1" valign="middle">&#x2003;&#x2003;Smartphone dependence or addiction</td>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.171</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;No dependence or addiction</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">13 (46.4)</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">15 (53.6)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;Dependence or addiction</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">33 (62.3)</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">20 (37.7)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Piura</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;Sex</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.141</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;Female</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">49 (57.0)</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">37 (43.0)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;Male</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">19 (73.1)</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">7 (26.9)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;Age (years)</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle"/>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.150</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2003;&#x2003;&#x2003;15 to 19</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">22 (75.9)</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">7 (24.1)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2003;&#x2003;&#x2003;20 to 24</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">19 (54.3)</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">16 (45.7)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2003;&#x2003;&#x2003;25 to 29</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">27 (56.2)</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">21 (43.7)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="2" rowspan="1" valign="middle">&#x2003;&#x2003;Smartphone dependence or addiction</td>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.003
                                <sup>
                                    <xref ref-type="table-fn" rid="tfn1">*</xref>
                                </sup>
                            </td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;No dependence or addiction</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">31 (79.5)</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">8 (20.5)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;Dependence or addiction</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">37 (50.7)</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">36 (49.3)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                    </tbody>
                </table>
                <table-wrap-foot>
                    <p>Statistical test: Pearson's Chi-square (&#x03c7;
                        <sup>2</sup>) test.</p>
                    <fn-group content-type="footnotes">
                        <fn id="tfn1">
                            <label>*</label>
                            <p>Values with statistical significance.</p>
                        </fn>
                    </fn-group>
                </table-wrap-foot>
            </table-wrap>
            <p>In Piura, although sex and age did not show significant associations, smartphone dependence or addiction did show a significant correlation, with a p-value of 0.003. Here it is observed that those with smartphone dependence or addiction present a higher prevalence (49.3%) of probable or definite bruxism.</p>
            <p>
                <xref ref-type="table" rid="T3">
Table 3</xref> presents PR through two models: a simple model and an adjusted model. In the simple model we observe that, in the population of young &#x201c;NEETs&#x201d; in Piura, the proportion of bruxism is 3.77 times higher in those with smartphone dependence or addiction, with a 95% CI [1.53-9.30]. In the adjusted model of the same population of young &#x201c;NEETs&#x201d; from Piura, this association is amplified since the group with smartphone dependence or addiction has a proportion of bruxism 5.38 times higher than those without such dependence (95% CI [2.05-14.12]).</p>
            <table-wrap id="T3" orientation="portrait" position="float">
                <label>
Table 3. </label>
                <caption>
                    <title>Ratio of Bruxism Proportions by Smartphone Dependence/Addiction in NEET Youth in Two Peruvian Coastal Cities.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="2" valign="bottom">City</th>
                            <th align="left" colspan="4" rowspan="1" valign="top">Simple Model</th>
                            <th align="left" colspan="4" rowspan="1" valign="top">Adjusted model</th>
                        </tr>
                        <tr>
                            <th align="left" colspan="1" rowspan="1" valign="top">PR</th>
                            <th align="left" colspan="2" rowspan="1" valign="top">CI 95%</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">p-value
</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">PR</th>
                            <th align="left" colspan="2" rowspan="1" valign="top">CI 95%</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">p-value
</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="3" rowspan="1" valign="middle">Chincha</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;Sex</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;Female</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Ref.</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;Male</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="middle">3.03</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.21</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">1.33</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.174</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;Age (years)</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;15 to 19</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Ref.</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;20 to 24</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.29</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.08</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">1.06</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.061</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;25 to 29</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.51</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.14</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">1.77</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.286</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="2" rowspan="1" valign="middle">&#x2003;&#x2003;Smartphone dependence or addiction</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;No dependence or addiction</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Ref.</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Ref.</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;Dependence or addiction</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.52</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.21</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">1.33</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.174</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.54</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.20</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">1.45</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.222</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="3" rowspan="1" valign="middle">Piura</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;Sex</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;Female</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Ref.</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;Male</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.35</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.12</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">1.01</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.052</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;Age</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;15 to 19 years old</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Ref.</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;20 to 24 years old</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="middle">3.46</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">1.09</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">10.96</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.035
                                <xref ref-type="table-fn" rid="tfn2">*</xref>
                            </td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="middle">&#x2003;&#x2003;&#x2003;&#x2003;25 to 29 years old</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="middle">3.12</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">1.03</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">9.39</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.043
                                <xref ref-type="table-fn" rid="tfn2">*</xref>
                            </td>
                        </tr>
                        <tr>
                            <td align="left" colspan="2" rowspan="1" valign="middle">&#x2003;&#x2003;Smartphone dependence or addiction</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2003;&#x2003;&#x2003;No dependence or addiction</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Ref.</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="middle">Ref.</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">&#x2003;&#x2003;&#x2003;&#x2003;Dependence or addiction</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">3.77</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">1.53</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">9.30</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.004
                                <xref ref-type="table-fn" rid="tfn2">*</xref>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">5.38</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">2.05</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">14.12</td>
                            <td align="left" colspan="1" rowspan="1" valign="middle">0.001
                                <xref ref-type="table-fn" rid="tfn2">*</xref>
                            </td>
                        </tr>
                    </tbody>
                </table>
                <table-wrap-foot>
                    <p>Statistical test: Logistic regression.</p>
                    <fn-group content-type="footnotes">
                        <fn id="tfn2">
                            <label>*</label>
                            <p>Values with statistical significance.</p>
                        </fn>
                    </fn-group>
                </table-wrap-foot>
            </table-wrap>
            <p>The population of young &#x201c;NEETs&#x201d; in Chincha shows a different pattern. The proportion of bruxism in those with smartphone dependence is 0.52 times that of those without dependence or addiction (95% CI [0.21-1.33]). Regarding the adjusted model for Chincha, the proportion of bruxism continues to show no significant association with sex, age or smartphone dependence or addiction. These observations suggest that in Chincha, bruxism is not strongly associated with sex, age, or smartphone dependence in the population studied.</p>
        </sec>
        <sec id="sec12" sec-type="discussion">
            <title>Discussion</title>
            <p>Our study revealed a significant association between bruxism and smartphone dependence or addiction in Piura, contrasting with the lack of significant relationship in Chincha. The significant association in Piura suggests that excessive smartphone use may be related to a higher occurrence of bruxism in this population, although the cross-sectional design does not allow the direction of this relationship to be established. The lack of a significant relationship in Chincha suggests that other factors may be more directly related to bruxism in this area, or that the way in which technological dependence affects individuals may vary depending on the urban environment and its specific characteristics.
                <sup>
                    <xref ref-type="bibr" rid="ref8">8</xref>
                </sup>
            </p>
            <p>Several factors may account for the regional difference observed between Piura and Chincha. First, the two samples differed substantially in composition and recruitment setting: in Piura participants were recruited at a maternal and child centre and were predominantly women (77.0%), whereas in Chincha they came from a private dental office with a balanced sex distribution (50% women). Differences in the underlying populations, in care-seeking behaviour and in the prevalence of unmeasured psychosocial stressors could plausibly modify the strength of the smartphone&#x2013;bruxism association across settings.
                <sup>
                    <xref ref-type="bibr" rid="ref29">14</xref>
                </sup> Second, because daily hours of smartphone use were not recorded, we cannot determine whether the two cities differed in the intensity or pattern of use, which limits the mechanistic interpretation of the contrast. Third, the modest size of the city-specific subgroups reduces statistical power and increases the influence of sampling variability, so part of the difference may reflect chance. These elements should be weighed together, and the regional contrast is best read as a hypothesis to be tested in larger, adequately powered studies rather than as established evidence of effect modification by city.</p>
            <p>The association between male sex and bruxism observed in Chincha also deserves comment, as it runs counter to the broader literature. Systematic reviews tend to report a slightly higher prevalence of (especially awake) bruxism in women, generally attributed within the biopsychosocial model to differences in exposure and response to psychosocial stress, in awareness and in reporting behaviour, rather than to a clear biological predisposition.
                <sup>
                    <xref ref-type="bibr" rid="ref29">14</xref>
                </sup> Our discrepant finding in Chincha may stem from the specific characteristics of male NEET youth in that setting&#x2014;who may face particular socioeconomic and psychosocial stressors&#x2014;from differences in self-report between sexes, or simply from the small cell counts and multiple comparisons involved. Because the present study did not measure anxiety, stress, sleep quality or other recognised etiological factors of bruxism, we cannot identify which parameter underlies the sex difference; this is an explicit limitation and a priority for future work, which should incorporate validated psychosocial and sleep instruments to disentangle these pathways.</p>
            <p>Comparing our findings with those of Prado et al.,
                <sup>
                    <xref ref-type="bibr" rid="ref14">17</xref>
                </sup> we note that both studies highlight a worrying correlation between intensive smartphone use and oral health problems such as bruxism. What distinguishes our research is the focus on young &#x201c;NEETs&#x201d;,
                <sup>
                    <xref ref-type="bibr" rid="ref15">18</xref>
                </sup> this specificity proposes that technological dependence is a generalized problem that has greater effects in groups with certain sociodemographic and economic characteristics.
                <sup>
                    <xref ref-type="bibr" rid="ref16">19</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref17">20</xref>
                </sup> The observation by Carrillo et al.
                <sup>
                    <xref ref-type="bibr" rid="ref18">21</xref>
                </sup> on the impact of lifestyle changes, such as increased physical inactivity during confinement, and its relationship with increased bruxism, finds a parallel in our results. However, our study was conducted outside periods of confinement, suggesting a more persistent and less circumstantial problem. This aligns with the findings of Emodi-Perlman et al.
                <sup>
                    <xref ref-type="bibr" rid="ref19">22</xref>
                </sup> and Tinastepe and Iscan,
                <sup>
                    <xref ref-type="bibr" rid="ref20">23</xref>
                </sup> who evidence a link between smartphone use and bruxism and reinforce our findings within a global context. On the other hand, the research by Chen et al.
                <sup>
                    <xref ref-type="bibr" rid="ref21">24</xref>
                </sup> expands the picture by linking sleep problems and Internet addiction to health disturbances, which enriches our understanding of how the overuse of digital technologies may affect other aspects of physical and mental well-being as well.
                <sup>
                    <xref ref-type="bibr" rid="ref20">23</xref>
                </sup>
                <sup>,</sup>
                <sup>
                    <xref ref-type="bibr" rid="ref21">24</xref>
                </sup>
            </p>
            <p>Among the strengths of our study is the focus on young &#x201c;NEETs&#x201d;, a segment of the population that is rarely the focus of attention in research on oral health and technology. This specific demographic focus offers crucial insights into how the particularities of this group may influence their relationship with technology and its impact on health.</p>
            <p>Despite its strengths, our study faced limitations, such as the reliance on self-reports to assess bruxism; this approach, although practical and widely used, may lead to response biases given that participants may underestimate or overestimate their smartphone use or the presence of bruxism symptoms.
                <sup>
                    <xref ref-type="bibr" rid="ref22">25</xref>
                </sup> Beyond self-report, several limitations should be emphasised. The cross-sectional design captures exposure and outcome simultaneously and therefore cannot establish temporality or causality. The use of non-probabilistic convenience sampling at two care settings introduces potential selection bias and limits the generalisability of the findings to the wider NEET population. Importantly, we did not measure daily hours of smartphone use or recognised predisposing factors of bruxism&#x2014;such as sleep disorders, anxiety, stress and other psychogenic factors, or swallowing problems&#x2014;so residual confounding cannot be ruled out and the underlying mechanisms cannot be disentangled. Finally, the modest size of the city-specific subgroups, together with the multiple stratified comparisons performed without correction and without an a priori power analysis, means that some associations may be unstable or due to chance. Taken together, these limitations do not invalidate the findings but require that they be interpreted with caution as exploratory and hypothesis-generating. They highlight the importance of conducting future research using mixed methods, combining self-reports with clinical examinations for bruxism and digital tracking of smartphone use. These more diversified methodological approaches would allow us to validate and deepen our findings, and to explore in greater detail the complex dynamics underlying the relationship between technology and oral health.</p>
            <p>The identification of a significant relationship between bruxism and smartphone dependence or addiction among socially and economically vulnerable youth, such as the &#x201c;NEETs&#x201d; group, underscores the urgent need to study technology dependence, and to consider strategies to prevent bruxism and other related oral health problems.
                <sup>
                    <xref ref-type="bibr" rid="ref23">26</xref>
                </sup> In addition, it is crucial to foster a collaboration between health professionals, educators, parents, and policy makers to create a supportive environment that facilitates young &#x201c;NEETs&#x201d; to adopt more balanced and healthy lifestyles. Future actions should include more detailed research that explores the underlying mechanisms of this relationship and evaluates the efficacy of specific interventions for this population.</p>
        </sec>
        <sec id="sec13">
            <title>Ethics and consent</title>
            <p>The study was approved with Official Letter from the Research Ethics Committee of the School of Stomatology N&#x00b0; 0109-2023-/UCV/P dated December 20, 2023. We adhered to the principles of the Declaration of Helsinki. Written consent was obtained from all participants.</p>
        </sec>
    </body>
    <back>
        <sec id="sec16" sec-type="data-availability">
            <title>Data availability</title>
            <sec id="sec17">
                <title>Underlying data</title>
                <p>Figshare: Dataset ninis. DOI: 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.6084/m9.figshare.25970653.v2">https://doi.org/10.6084/m9.figshare.25970653.v2</ext-link>.
                    <sup>
                        <xref ref-type="bibr" rid="ref24">27</xref>
                    </sup>
                </p>
                <p>Data are available under the terms of the 
                    <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International license</ext-link> (CC-BY 4.0).</p>
            </sec>
            <sec id="sec18">
                <title>Extended data</title>
                <p>Figshare: Smartphone Addiction and Dependence Scale &#x2013; 18 items (SADS-18). DOI: 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.6084/m9.figshare.26210552.v1">https://doi.org/10.6084/m9.figshare.26210552.v1</ext-link>.
                    <sup>
                        <xref ref-type="bibr" rid="ref25">28</xref>
                    </sup>
                </p>
                <p>Data are available under the terms of the 
                    <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International license</ext-link> (CC-BY 4.0).</p>
                <p>Figshare: Self-reported bruxism questionnaire (SRBQ). DOI: 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.6084/m9.figshare.26210573.v1">https://doi.org/10.6084/m9.figshare.26210573.v1</ext-link>.
                    <sup>
                        <xref ref-type="bibr" rid="ref26">29</xref>
                    </sup>
                </p>
                <p>Data are available under the terms of the 
                    <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International license</ext-link> (CC-BY 4.0).</p>
            </sec>
        </sec>
        <ref-list>
            <title>References</title>
            <ref id="ref1">
                <label>1</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Ratan</surname>
                            <given-names>Z</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Parrish</surname>
                            <given-names>A-M</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Zaman</surname>
                            <given-names>S</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Smartphone Addiction and Associated Health Outcomes in Adult Populations: A Systematic Review.</article-title>
                    <source>

                        <italic toggle="yes">Int. J. Environ. Res. Public Health.</italic>
</source>
                    <year>2021 Nov 22</year>;<volume>18</volume>(<issue>22</issue>):<fpage>12257</fpage>.
                    <pub-id pub-id-type="pmid">34832011</pub-id>
                    <pub-id pub-id-type="doi">10.3390/ijerph182212257</pub-id>
                    <pub-id pub-id-type="pmcid">PMC8622754</pub-id>
                    <ext-link ext-link-type="uri" xlink:href="https://www.mdpi.com/1660-4601/18/22/12257">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref2">
                <label>2</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Uzun&#x00e7;akmak</surname>
                            <given-names>T</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Ayaz-Alkaya</surname>
                            <given-names>S</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Akca</surname>
                            <given-names>A</given-names>
                        </name>
</person-group>:
                    <article-title>Prevalence and predisposing factors of smartphone addiction, sleep quality and daytime sleepiness of nursing students: A cross-sectional design.</article-title>
                    <source>

                        <italic toggle="yes">Nurse Educ. Pract.</italic>
</source>
                    <year>2022 Nov</year>;<volume>65</volume>:<fpage>103478</fpage>.
                    <pub-id pub-id-type="pmid">36327595</pub-id>
                    <pub-id pub-id-type="doi">10.1016/j.nepr.2022.103478</pub-id>
                    <ext-link ext-link-type="uri" xlink:href="https://linkinghub.elsevier.com/retrieve/pii/S1471595322001925">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref3">
                <label>3</label>
                <mixed-citation publication-type="book">
                    <collab>Banco Mundial</collab>:
                    <source>

                        <italic toggle="yes">Personas que usan Internet (% de la poblaci&#x00f3;n) - United States.</italic>
</source>
                    <publisher-name>DataBank</publisher-name>;<year>2023</year>.
                    <ext-link ext-link-type="uri" xlink:href="https://datos.bancomundial.org/indicator/IT.NET.USER.ZS?locations=US">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref4">
                <label>4</label>
                <mixed-citation publication-type="other">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Ruiz</surname>
                            <given-names>CR</given-names>
                        </name>
</person-group>:
                    <source>

                        <italic toggle="yes">Estad&#x00ed;sticas de las Tecnolog&#x00ed;as de la Informaci&#x00f3;n y Comunicaci&#x00f3;n en los hogares.</italic>
</source>
                    <publisher-loc>Lima</publisher-loc>:<year>2022</year>.
                    <ext-link ext-link-type="uri" xlink:href="https://www.inei.gob.pe/media/MenuRecursivo/boletines/02-informe-tecnico-tic-i-trimestre-2022.pdf">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref5">
                <label>5</label>
                <mixed-citation publication-type="book">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Ting</surname>
                            <given-names>CH</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Chen</surname>
                            <given-names>YY</given-names>
                        </name>
</person-group>:
                    <chapter-title>Smartphone addiction.</chapter-title>
                    <source>

                        <italic toggle="yes">Adolescent Addiction.</italic>
</source>
                    <publisher-name>Elsevier</publisher-name>;<year>2020</year>; p.<fpage>215</fpage>&#x2013;<lpage>40</lpage>.
                    <ext-link ext-link-type="uri" xlink:href="https://linkinghub.elsevier.com/retrieve/pii/B9780128186268000086">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref6">
                <label>6</label>
                <mixed-citation publication-type="other">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Kemp</surname>
                            <given-names>S</given-names>
                        </name>
</person-group>:
                    <article-title>Digital 2022: July Global Statshot Report.</article-title>
                    <year>2022</year>.
                    <ext-link ext-link-type="uri" xlink:href="https://datareportal.com/reports/digital-2022-july-global-statshot">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref7">
                <label>7</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Sim&#x00f3; Sanz</surname>
                            <given-names>C</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Martinez Sabater</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Ballestar Tar&#x00ed;n</surname>
                            <given-names>ML</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Instrumentos de evaluaci&#x00f3;n del uso problem&#x00e1;tico del tel&#x00e9;fono m&#x00f3;vil/Smartphone.</article-title>
                    <source>

                        <italic toggle="yes">Heal Addict y Drog.</italic>
</source>
                    <year>2017 Jan 31</year>;<volume>17</volume>(<issue>1</issue>):<fpage>5</fpage>&#x2013;<lpage>14</lpage>.
                    <pub-id pub-id-type="doi">10.21134/haaj.v17i1.265</pub-id>
                    <ext-link ext-link-type="uri" xlink:href="https://ojs.haaj.org/index.php/haaj/article/view/265">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref8">
                <label>8</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Olivella-Cirici</surname>
                            <given-names>M</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Garcia-Continente</surname>
                            <given-names>X</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Bartroli Checa</surname>
                            <given-names>M</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>The problematic use of the mobile phone: cross-sectional analysis of the individual profile and associated factors.</article-title>
                    <source>

                        <italic toggle="yes">Rev. Esp. Salud Publica.</italic>
</source>
                    <year>2023 May 3</year>;<volume>97</volume>.
                    <ext-link ext-link-type="uri" xlink:href="http://www.ncbi.nlm.nih.gov/pubmed/37132395">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref9">
                <label>9</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Tarazona Jim&#x00e9;nez</surname>
                            <given-names>J</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Vargas Arce</surname>
                            <given-names>D</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Huam&#x00e1;n Magui&#x00f1;a</surname>
                            <given-names>L</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Los j&#x00f3;venes NEETs en pandemia y sus determinantes.</article-title>
                    <source>

                        <italic toggle="yes">Econ y Adminstraci&#x00f3;n.</italic>
</source>
                    <year>2023</year>;<volume>3</volume>(<issue>1</issue>).
                    <ext-link ext-link-type="uri" xlink:href="https://revistas.unasam.edu.pe/index.php/llalliq/article/view/1041/1117">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref10">
                <label>10</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Lobbezoo</surname>
                            <given-names>F</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Ahlberg</surname>
                            <given-names>J</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Raphael</surname>
                            <given-names>KG</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>International consensus on the assessment of bruxism: Report of a work in progress.</article-title>
                    <source>

                        <italic toggle="yes">J. Oral Rehabil.</italic>
</source>
                    <year>2018 Nov 21</year>;<volume>45</volume>(<issue>11</issue>):<fpage>837</fpage>&#x2013;<lpage>844</lpage>.
                    <pub-id pub-id-type="pmid">29926505</pub-id>
                    <pub-id pub-id-type="doi">10.1111/joor.12663</pub-id>
                    <pub-id pub-id-type="pmcid">PMC6287494</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref11">
                <label>11</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Melo</surname>
                            <given-names>G</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Duarte</surname>
                            <given-names>J</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Pauletto</surname>
                            <given-names>P</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Bruxism: An umbrella review of systematic reviews.</article-title>
                    <source>

                        <italic toggle="yes">J. Oral Rehabil.</italic>
</source>
                    <year>2019 Jul 7</year>;<volume>46</volume>(<issue>7</issue>):<fpage>666</fpage>&#x2013;<lpage>690</lpage>.
                    <pub-id pub-id-type="pmid">30993738</pub-id>
                    <pub-id pub-id-type="doi">10.1111/joor.12801</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref27">
                <label>12</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Abdul</surname>
                            <given-names>NS</given-names>
                        </name>
</person-group>:
                    <article-title>A Systematic Review on the Impact of Smartphone Usage on Temporomandibular Disorders.</article-title>
                    <source>

                        <italic toggle="yes">Cureus.</italic>
</source>
                    <year>2025</year>;<volume>17</volume>(<issue>10</issue>):<fpage>e95683</fpage>.
                    <pub-id pub-id-type="pmid">41322918</pub-id>
                    <pub-id pub-id-type="doi">10.7759/cureus.95683</pub-id>
                    <pub-id pub-id-type="pmcid">PMC12662257</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref28">
                <label>13</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Foltran-Mescollotto</surname>
                            <given-names>F</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Gon&#x00e7;alves</surname>
                            <given-names>&#x00c9;B</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Castro-Carletti</surname>
                            <given-names>EM</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Smartphone addiction and the relationship with head and neck pain and electromyographic activity of masticatory muscles.</article-title>
                    <source>

                        <italic toggle="yes">Work.</italic>
</source>
                    <year>2021</year>;<volume>68</volume>(<issue>3</issue>):<fpage>633</fpage>&#x2013;<lpage>640</lpage>.
                    <pub-id pub-id-type="pmid">33612508</pub-id>
                    <pub-id pub-id-type="doi">10.3233/WOR-203398</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref29">
                <label>14</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Chemelo</surname>
                            <given-names>VS</given-names>
                        </name>

                        <name name-style="western">
                            <surname>N&#x00e9;</surname>
                            <given-names>YGS</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Fraz&#x00e3;o</surname>
                            <given-names>DR</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Is There Association Between Stress and Bruxism? A Systematic Review and Meta-Analysis.</article-title>
                    <source>

                        <italic toggle="yes">Front. Neurol.</italic>
</source>
                    <year>2020</year>;<volume>11</volume>:<fpage>590779</fpage>.
                    <pub-id pub-id-type="pmid">33424757</pub-id>
                    <pub-id pub-id-type="doi">10.3389/fneur.2020.590779</pub-id>
                    <pub-id pub-id-type="pmcid">PMC7793806</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref12">
                <label>15</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>S&#x00e1;nchez-Villena</surname>
                            <given-names>AR</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Dom&#x00ed;nguez-Lara</surname>
                            <given-names>S</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Aranda</surname>
                            <given-names>M</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>An&#x00e1;lisis estructural de la escala de dependencia y adicci&#x00f3;n al smartphone (EDAS) en universitarios peruanos.</article-title>
                    <source>

                        <italic toggle="yes">Heal Addict y Drog.</italic>
</source>
                    <year>2021 Aug 12</year>;<volume>21</volume>(<issue>2</issue>):<fpage>93</fpage>&#x2013;<lpage>113</lpage>.
                    <pub-id pub-id-type="doi">10.21134/haaj.v21i2.572</pub-id>
                    <ext-link ext-link-type="uri" xlink:href="https://ojs.haaj.org/?journal=haaj&amp;page=article&amp;op=view&amp;path%5B%5D=572">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref13">
                <label>16</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Cruz Fierro</surname>
                            <given-names>N</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Gonz&#x00e1;lez Ram&#x00ed;rez</surname>
                            <given-names>MT</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Farfano</surname>
                            <given-names>JV</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Cuestionario de bruxismo autoinformado. Estudio piloto en el noreste de M&#x00e9;xico.</article-title>
                    <source>

                        <italic toggle="yes">Interdiscip Rev Psicol y Ciencias Afines.</italic>
</source>
                    <year>2019 Dec 1</year>;<volume>36</volume>(<issue>2</issue>).
                    <pub-id pub-id-type="doi">10.16888/interd.2019.36.2.14</pub-id>
                    <ext-link ext-link-type="uri" xlink:href="http://www.ciipme-conicet.gov.ar/ojs/index.php?journal=interdisciplinaria&amp;page=article&amp;op=view&amp;path%5B%5D=661&amp;path%5B%5D=pdf">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref14">
                <label>17</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Carrillo-Esper</surname>
                            <given-names>R</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Alberto D&#x00ed;az Ponce-Medrano</surname>
                            <given-names>J</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Antonio Garnica-Escamilla</surname>
                            <given-names>M</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Evaluaci&#x00f3;n nutricional en el perioperatorio.</article-title>
                    <source>

                        <italic toggle="yes">Rev Mex Anestesiol.</italic>
</source>
                    <year>2017 Apr [cited 2022 Jul 19]</year>;<volume>40</volume>(<issue>2</issue>):<fpage>129</fpage>&#x2013;<lpage>133</lpage>.
                    <ext-link ext-link-type="uri" xlink:href="https://www.medigraphic.com/pdfs/rma/cma-2017/cma172j.pdf">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref15">
                <label>18</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Prado</surname>
                            <given-names>IM</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Perazzo</surname>
                            <given-names>M d F</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Abreu</surname>
                            <given-names>LG</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Possible sleep bruxism, smartphone addiction and sleep quality among Brazilian university students during COVID-19 pandemic.</article-title>
                    <source>

                        <italic toggle="yes">Sleep Sci.</italic>
</source>
                    <year>2022 Jun 1</year>;<volume>15</volume>(<issue>02</issue>):<fpage>158</fpage>&#x2013;<lpage>167</lpage>.
                    <pub-id pub-id-type="pmid">35755907</pub-id>
                    <pub-id pub-id-type="doi">10.5935/1984-0063.20220036</pub-id>
                    <pub-id pub-id-type="pmcid">PMC9210567</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref16">
                <label>19</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Balarezo</surname>
                            <given-names>LG</given-names>
                        </name>
</person-group>:
                    <article-title>Generaci&#x00f3;n NEET: J&#x00f3;venes Que Ni Estudian Ni Trabajan.</article-title>
                    <source>

                        <italic toggle="yes">Paid XXI.</italic>
</source>
                    <year>2019 Sep 27</year>;<volume>9</volume>(<issue>1</issue>):<fpage>77</fpage>&#x2013;<lpage>103</lpage>.
                    <ext-link ext-link-type="uri" xlink:href="https://revistas.urp.edu.pe/index.php/Paideia/article/view/2266">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref17">
                <label>20</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Mawn</surname>
                            <given-names>L</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Oliver</surname>
                            <given-names>EJ</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Akhter</surname>
                            <given-names>N</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Are we failing young people not in employment, education or training (NEETs)? A systematic review and meta-analysis of re-engagement interventions.</article-title>
                    <source>

                        <italic toggle="yes">Syst. Rev.</italic>
</source>
                    <year>2017 Dec 25</year>;<volume>6</volume>(<issue>1</issue>):<fpage>16</fpage>.
                    <pub-id pub-id-type="pmid">28122584</pub-id>
                    <pub-id pub-id-type="doi">10.1186/s13643-016-0394-2</pub-id>
                    <pub-id pub-id-type="pmcid">PMC5264339</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref18">
                <label>21</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Carrillo-Diaz</surname>
                            <given-names>M</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Ortega-Mart&#x00ed;nez</surname>
                            <given-names>AR</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Romero-Maroto</surname>
                            <given-names>M</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>Lockdown impact on lifestyle and its association with oral parafunctional habits and bruxism in a Spanish adolescent population.</article-title>
                    <source>

                        <italic toggle="yes">Int. J. Paediatr. Dent.</italic>
</source>
                    <year>2022 Mar 18</year>;<volume>32</volume>(<issue>2</issue>):<fpage>185</fpage>&#x2013;<lpage>193</lpage>.
                    <pub-id pub-id-type="pmid">34046944</pub-id>
                    <pub-id pub-id-type="doi">10.1111/ipd.12843</pub-id>
                    <pub-id pub-id-type="pmcid">PMC8242462</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref19">
                <label>22</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Emodi-Perlman</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Hochhauser</surname>
                            <given-names>T</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Winocur</surname>
                            <given-names>P</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>The effect of smartphones on daytime sleepiness, temporomandibular disorders, and bruxism among young adults.</article-title>
                    <source>

                        <italic toggle="yes">Quintessence Int.</italic>
</source>
                    <year>2021 May 7</year>;<volume>52</volume>(<issue>6</issue>):<fpage>548</fpage>&#x2013;<lpage>59</lpage>.
                    <pub-id pub-id-type="pmid">33880912</pub-id>
                    <pub-id pub-id-type="doi">10.3290/j.qi.b1244431</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref20">
                <label>23</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Tinastepe</surname>
                            <given-names>N</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Iscan</surname>
                            <given-names>I</given-names>
                        </name>
</person-group>:
                    <article-title>Relationship between bruxism and smartphone overuse in young adults.</article-title>
                    <source>

                        <italic toggle="yes">Cranio.</italic>
</source>
                    <year>2024 Jan 2</year>;<volume>42</volume>(<issue>1</issue>):<fpage>55</fpage>&#x2013;<lpage>62</lpage>.
                    <pub-id pub-id-type="pmid">33787472</pub-id>
                    <pub-id pub-id-type="doi">10.1080/08869634.2021.1909456</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref21">
                <label>24</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Chen</surname>
                            <given-names>Y-L</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Gau</surname>
                            <given-names>SS-F</given-names>
                        </name>
</person-group>:
                    <article-title>Sleep problems and internet addiction among children and adolescents: a longitudinal study.</article-title>
                    <source>

                        <italic toggle="yes">J. Sleep Res.</italic>
</source>
                    <year>2016 Aug</year>;<volume>25</volume>(<issue>4</issue>):<fpage>458</fpage>&#x2013;<lpage>65</lpage>.
                    <pub-id pub-id-type="pmid">26854132</pub-id>
                    <pub-id pub-id-type="doi">10.1111/jsr.12388</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref22">
                <label>25</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Zurita-Cruz</surname>
                            <given-names>JN</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Villas&#x00ed;s-Keever</surname>
                            <given-names>M&#x00c1;</given-names>
                        </name>
</person-group>:
                    <article-title>Principales sesgos en la investigaci&#x00f3;n cl&#x00ed;nica.</article-title>
                    <source>

                        <italic toggle="yes">Rev Alerg M&#x00e9;xico.</italic>
</source>
                    <year>2021 Dec 8</year>;<volume>68</volume>(<issue>4</issue>):<fpage>291</fpage>&#x2013;<lpage>299</lpage>.
                    <pub-id pub-id-type="pmid">34904564</pub-id>
                    <pub-id pub-id-type="doi">10.29262/ram.v68i4.1003</pub-id>
                    <ext-link ext-link-type="uri" xlink:href="http://revistaalergia.mx/ojs/index.php/ram/article/view/1003">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref23">
                <label>26</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Barranca-Enr&#x00ed;quez</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Romo-Gonz&#x00e1;lez</surname>
                            <given-names>T</given-names>
                        </name>
</person-group>:
                    <article-title>Your health is in your mouth: A comprehensive view to promote general wellness.</article-title>
                    <source>

                        <italic toggle="yes">Front Oral Heal.</italic>
</source>
                    <year>2022 Sep 14</year>;<volume>3</volume>.
                    <pub-id pub-id-type="doi">10.3389/froh.2022.971223/full</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref24">
                <label>27</label>
                <mixed-citation publication-type="other">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Orrego-Ferreyros</surname>
                            <given-names>LA</given-names>
                        </name>
</person-group>:
                    <article-title>Dataset ninis.</article-title>
                    <source>

                        <italic toggle="yes">figshare.</italic>
</source>
                    <year>2024</year>.
                    <pub-id pub-id-type="doi">10.6084/m9.figshare.25970653</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref25">
                <label>28</label>
                <mixed-citation publication-type="other">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Orrego-Ferreyros</surname>
                            <given-names>LA</given-names>
                        </name>
</person-group>:
                    <article-title>Smartphone Addiction and Dependence Scale &#x2013; 18 items.</article-title>
                    <source>

                        <italic toggle="yes">figshare.</italic>
</source>
                    <year>2024</year>.
                    <pub-id pub-id-type="doi">10.6084/m9.figshare.26210552.v1</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref26">
                <label>29</label>
                <mixed-citation publication-type="other">
                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Orrego-Ferreyros</surname>
                            <given-names>LA</given-names>
                        </name>
</person-group>:
                    <article-title>Self-reported bruxism questionnaire (SRBQ).</article-title>
                    <source>

                        <italic toggle="yes">figshare.</italic>
</source>
                    <year>2024</year>.
                    <pub-id pub-id-type="doi">10.6084/m9.figshare.26210573.v1</pub-id>
                </mixed-citation>
            </ref>
        </ref-list>
    </back>
    <sub-article article-type="reviewer-report" id="report347972">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.167577.r347972</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Ceylan</surname>
                        <given-names>Ali</given-names>
                    </name>
                    <xref ref-type="aff" rid="r347972a1">1</xref>
                    <role>Referee</role>
                </contrib>
                <aff id="r347972a1">
                    <label>1</label>Karamanoglu Mehmetbey Universitesi, Karaman, Karaman, Turkey</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>14</day>
                <month>12</month>
                <year>2024</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2024 Ceylan A</copyright-statement>
                <copyright-year>2024</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport347972" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.152778.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>reject</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>Dear author(s),</p>
            <p> </p>
            <p> Your study may be unique in terms of technology use and reflecting jaw problems; however, I think that an inadequate research form was prepared at the data collection stage. I would like to express my comments on the study.</p>
            <p> Introduction</p>
            <p> &#x00a0; 
                <list list-type="order">
                    <list-item>
                        <p>In the introduction part of the article, after providing general information about the changes caused by the smartphone in the human body and posture, hypotheses that can explain the relationship between it and bruxism should be included. In this respect, I think the introduction part of the article is insufficient.</p>
                    </list-item>
                    <list-item>
                        <p>Literature reviews on whether or not there is a relationship between regional differences and bruxism should be included.</p>
                    </list-item>
                </list> </p>
            <p> Methods 
                <list list-type="order">
                    <list-item>
                        <p>Why was the population in the 15-29 age group included? Was power analysis performed when determining the sample size before the study? Or was a pilot study conducted during the study and a power analysis conducted as a result? Was a power analysis performed at the end of the study? If so, these should be presented in the statistics section. If not, the sample size may be of concern in terms of bias.</p>
                    </list-item>
                    <list-item>
                        <p>Was daily smartphone usage time recorded by the researcher? For example, was 4 hours considered as a cut-off value and above this value was categorized as heavy</p>
                    </list-item>
                </list> </p>
            <p> Discussion</p>
            <p> &#x00a0; 
                <list list-type="order">
                    <list-item>
                        <p>What was the reason for the regional difference in the relationship between bruxism and smartphone addiction? At this point, if the daily smart phone usage time of the participants was recorded, it may be important to share these results. Or for what reason and justification did you explain this difference? It is unclear.</p>
                    </list-item>
                    <list-item>
                        <p>What do you think is the basis for the different results between gender and bruxism? Which parameter may have caused this difference between the sexes? I think there are not enough questions in the data collection methods. The underlying causes of bruxism should be investigated and these should be included in the research form. For example, swallowing problems, sleep problems or psychogenic factors may also cause bruxism. The fact that only evaluation questions about telephone use were asked does not make the research unique.</p>
                    </list-item>
                    <list-item>
                        <p>The fact that the discussion is not sufficiently addressed according to the results of the findings, and that the cause-effect relationship related to the significant parameters is not fully established, makes the study uncertain.</p>
                    </list-item>
                </list>
            </p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Partly</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Partly</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Partly</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>No</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>No</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>No</p>
            <p>Reviewer Expertise:</p>
            <p>exercise, diabetes mellitus, diabetes mellitus, physiotherapy and rehabilitation, spine health, swallowing, smartphones</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above.</p>
        </body>
        <sub-article article-type="response" id="comment14348-347972">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>CEYLAN</surname>
                            <given-names>AL&#x0130;</given-names>
                        </name>
                        <aff>Therapy and Rehabilitation, Karamanoglu Mehmetbey University, Karaman, Karaman, Turkey</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>12</day>
                    <month>8</month>
                    <year>2025</year>
                </pub-date>
            </front-stub>
            <body>
                <p>As a referee for this study, I believe that the necessary corrections should be made and responses to the criticisms should be provided.</p>
            </body>
        </sub-article>
    </sub-article>
</article>
