<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN" "http://jats.nlm.nih.gov/publishing/1.2/JATS-journalpublishing1.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="research-article" dtd-version="1.2" xml:lang="en">
    <front>
        <journal-meta>
            <journal-id journal-id-type="pmc">F1000Research</journal-id>
            <journal-title-group>
                <journal-title>F1000Research</journal-title>
            </journal-title-group>
            <issn pub-type="epub">2046-1402</issn>
            <publisher>
                <publisher-name>F1000 Research Limited</publisher-name>
                <publisher-loc>London, UK</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="doi">10.12688/f1000research.168632.2</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Research Article</subject>
                </subj-group>
                <subj-group>
                    <subject>Articles</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Mapping Multisensory Journeys in Pediatric Oncology Care: Toward Emotionally Intelligent Healthcare Environments</article-title>
                <fn-group content-type="pub-status">
                    <fn>
                        <p>[version 2; peer review: 1 approved]</p>
                    </fn>
                </fn-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Rucitra</surname>
                        <given-names>Anggra Ayu</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-3766-0606</uri>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="yes">
                    <name>
                        <surname>Setijanti</surname>
                        <given-names>Purwanita</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="corresp" rid="c1">a</xref>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Dinapradipta</surname>
                        <given-names>Asri</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0001-9686-0950</uri>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <aff id="a1">
                    <label>1</label>Architecture Department, Institut Teknologi Sepuluh Nopember, Surabaya, East Java, Indonesia</aff>
            </contrib-group>
            <author-notes>
                <corresp id="c1">
                    <label>a</label>
                    <email xlink:href="mailto:p.setijanti@its.ac.id">p.setijanti@its.ac.id</email>
                </corresp>
                <fn fn-type="conflict">
                    <p>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>4</day>
                <month>2</month>
                <year>2026</year>
            </pub-date>
            <pub-date pub-type="collection">
                <year>2025</year>
            </pub-date>
            <volume>14</volume>
            <elocation-id>1151</elocation-id>
            <history>
                <date date-type="accepted">
                    <day>2</day>
                    <month>2</month>
                    <year>2026</year>
                </date>
            </history>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2026 Rucitra AA et al.</copyright-statement>
                <copyright-year>2026</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <self-uri content-type="pdf" xlink:href="https://f1000research.com/articles/14-1151/pdf"/>
            <abstract>
                <sec>
                    <title>Background</title>
                    <p>This study explores how sensory experiences within hospital environments influence the emotional responses of pediatric cancer patients, particularly those undergoing palliative chemotherapy. Pediatric journeys through healthcare spaces are not solely defined by clinical interactions but are shaped by continuous sensory exposure. This research aims to examine how visual, auditory, tactile, and olfactory inputs during hospital stays affect emotional regulation, stress, and readiness for treatment among children.</p>
                </sec>
                <sec>
                    <title>Methods</title>
                    <p>A qualitative, exploratory design was used, applying an interpretive approach to capture nuanced emotional experiences. Data collection involved semi-structured interviews with pediatric patients and caregivers, direct environmental observation, and multisensory journey mapping. Emotional responses were coded and interpreted using thematic analysis, supported by the Pleasure-Arousal-Dominance (PAD) emotional framework to identify patterns of engagement and disengagement across different sensory touchpoints.</p>
                </sec>
                <sec>
                    <title>Result</title>
                    <p>Findings show that children exposed to coherent multisensory environments&#x2014;those with soft lighting, comforting textures, and calming sounds&#x2014;demonstrated reduced anxiety and enhanced emotional coping. In contrast, fragmented environments with clinical noises, sterile visuals, and abrupt transitions intensified emotional distress, confusion, and behavioral withdrawal. Key friction points were not associated with medical procedures alone but often emerged from sensory overload or absence of meaningful sensory stimuli during waiting or transitional phases.</p>
                </sec>
                <sec>
                    <title>Conclusion</title>
                    <p>Hospital environments in pediatric oncology settings significantly contribute to the emotional quality of care. Sensory design that integrates adaptable, trauma-informed, and child-centered features can reduce stress and foster emotional resilience. This study suggests the need for multisensory design frameworks that move beyond aesthetics to support children&#x2019;s agency and well-being throughout their treatment journey.</p>
                </sec>
            </abstract>
            <kwd-group kwd-group-type="author">
                <kwd>Multisensory design</kwd>
                <kwd>pediatric oncology</kwd>
                <kwd>emotional mapping</kwd>
                <kwd>healthcare environment</kwd>
                <kwd>patient experience.</kwd>
            </kwd-group>
            <funding-group>
                <funding-statement>The author(s) declared that no grants were involved in supporting this work.</funding-statement>
            </funding-group>
        </article-meta>
        <notes>
            <sec sec-type="version-changes">
                <label>Revised</label>
                <title>Amendments from Version 1</title>
                <p>This revised manuscript improves conceptual clarity, methodological transparency, and readability in response to reviewer feedback. The Results&#x2013;Discussion section was streamlined by reducing repetitive theoretical citations already introduced in the Introduction and emphasizing data-driven interpretation. Terminology was standardized throughout the manuscript to ensure consistency in references to multisensory journey mapping, stress-level groupings, and pediatric oncology patients. Minor grammatical and typographical issues were corrected, and long sentences were refined for clarity. Methodological transparency was enhanced through the addition of a concise explanation describing how patients&#x2019; verbal expressions were coded and mapped onto the PAD (Pleasure&#x2013;Arousal&#x2013;Dominance) quadrants in Figures 2 and 3 using established valence criteria. Finally, the Conclusion was expanded to acknowledge contextual variability across hospital settings and cultural environments while emphasizing the broader transferability of the principle of sensory coherence. These revisions strengthen the manuscript without altering its core findings.</p>
            </sec>
        </notes>
    </front>
    <body>
        <sec id="sec5" sec-type="intro">
            <title>1. Introduction</title>
            <p>In the growing body of healthcare design literature, there is increasing recognition of how healing environments influence patients&#x2019; emotions, behaviors, and physiological health throughout the treatment journey (
                <xref ref-type="bibr" rid="ref10">DiCrescenzo, 2021</xref>; 
                <xref ref-type="bibr" rid="ref20">Kipps &amp; Erdman, 2025</xref>). Spatial design is therefore closely aligned with the fundamental and holistic needs of patients, aiming to support recovery throughout the healing process (
                <xref ref-type="bibr" rid="ref12">Gallan et al., 2019</xref>; 
                <xref ref-type="bibr" rid="ref13">Ghazali &amp; Abbas, 2012</xref>). This is particularly critical for pediatric cancer patients who face significant physical and emotional challenges throughout their treatment trajectory (
                <xref ref-type="bibr" rid="ref35">Rezaee Vessal et al., 2024</xref>). Despite architectural design often lacking representation of the emotional and sensory dimensions of healthcare environments (
                <xref ref-type="bibr" rid="ref42">Simonsen et al., 2022</xref>), multisensory support remains vital as a multifaceted intervention. It integrates auditory, emotional, cognitive, and physical systems to provide motivation and emotional reinforcement (
                <xref ref-type="bibr" rid="ref35">Rezaee Vessal et al., 2024</xref>). Previous studies have highlighted how emotionally responsive environments offer a unique escape from emotional pain (
                <xref ref-type="bibr" rid="ref2">Bearss &amp; Desouza, 2021</xref>; 
                <xref ref-type="bibr" rid="ref31">Qi et al., 2022</xref>; 
                <xref ref-type="bibr" rid="ref44">Sturm et al., 2014</xref>). 
                <xref ref-type="bibr" rid="ref50">Vi&#x00f1;a et al. (2013)</xref> noted that pediatric oncology facilities often prioritize functionality over the lived experience of patients, despite heightened emotional sensitivity during chemotherapy. 
                <xref ref-type="bibr" rid="ref35">Rezaee Vessal et al. (2024)</xref> also emphasize a significant research gap regarding the extent to which multisensory design influences patient individuality and overall care experiences.</p>
            <p>To address this research gap, the present study repositions hospital environments as active spatial agents that shape emotional readiness and psychological comfort, particularly through multisensory design. This holistic perspective encompasses both theoretical and practical frameworks in healthcare services that promote adaptability to patient needs and preferences to enhance physiological health and resilience (
                <xref ref-type="bibr" rid="ref21">L&#x00ea; Van et al., 2023</xref>; 
                <xref ref-type="bibr" rid="ref52">Yap et al., 2022</xref>). Understanding the active navigation of pediatric cancer patients through healthcare services can enrich knowledge of the patient journey (
                <xref ref-type="bibr" rid="ref35">Rezaee Vessal et al., 2024</xref>). 
                <xref ref-type="bibr" rid="ref52">Yap et al. (2022)</xref> emphasize that hospital user experience is shaped by a series of touchpoints encompassing core service aspects, which can be investigated across pre-treatment, treatment, and post-treatment phases (
                <xref ref-type="bibr" rid="ref22">Lemon &amp; Verhoef, 2016</xref>; 
                <xref ref-type="bibr" rid="ref49">Verhoef et al., 2009</xref>). Each touchpoint introduces sensory stimuli such as visual, auditory, tactile, and olfactory cues (
                <xref ref-type="bibr" rid="ref35">Rezaee Vessal et al., 2024</xref>), significantly influencing children&#x2019;s emotional states, anxiety levels, and treatment readiness (
                <xref ref-type="bibr" rid="ref37">Rucitra et al., 2024</xref>). These aspects must be considered in pediatric healthcare settings. 
                <xref ref-type="bibr" rid="ref20">Kipps and Erdman (2025)</xref> also stress that hospitals must address holistic healing environments that meet the physiological, cognitive, and emotional needs of children, which differ from those of adults, while accommodating the wider support systems surrounding pediatric patients.</p>
            <p>In this vein, the healing environment literature has demonstrated how hospital design affects patient outcomes and satisfaction (
                <xref ref-type="bibr" rid="ref23">Mahmood &amp; Tayib, 2021</xref>; 
                <xref ref-type="bibr" rid="ref32">Rafeeq &amp; Mustafa, 2021</xref>; 
                <xref ref-type="bibr" rid="ref36">Rich et al., 2021</xref>; 
                <xref ref-type="bibr" rid="ref48">Van Hoof et al., 2015</xref>). 
                <xref ref-type="bibr" rid="ref36">Rich et al. (2021)</xref> show that hospitals integrating healing environments significantly improve patient satisfaction regarding comfort, noise, temperature, and aesthetics. 
                <xref ref-type="bibr" rid="ref19">Khodeir and Gamal (2018)</xref> argue that physical environments play a key role in patient health and well-being. Nevertheless, 
                <xref ref-type="bibr" rid="ref42">Simonsen et al. (2022)</xref> highlight the limited understanding of how healing architecture affects clinical outcomes. Other studies have shown that under conditions of physical discomfort, uncertainty, or anxiety, patients become deeply connected to and affected by their surroundings (e.g., 
                <xref ref-type="bibr" rid="ref19">Khodeir &amp; Gamal, 2018</xref>; 
                <xref ref-type="bibr" rid="ref32">Rafeeq &amp; Mustafa, 2021</xref>; 
                <xref ref-type="bibr" rid="ref36">Rich et al., 2021</xref>). In this context, multisensory stimulation becomes especially relevant, as pediatric oncology environments often fail to foster a healing atmosphere, thereby affecting patients&#x2019; well-being and recovery (
                <xref ref-type="bibr" rid="ref5">Cheung et al., 2021</xref>; 
                <xref ref-type="bibr" rid="ref8">Das, 2025</xref>). Although studies on multisensory design have begun to explore how hospital sensory conditions mitigate stress and promote healing (e.g., 
                <xref ref-type="bibr" rid="ref1">Batchelor et al., 2023</xref>; 
                <xref ref-type="bibr" rid="ref5">Cheung et al., 2021</xref>; 
                <xref ref-type="bibr" rid="ref35">Rezaee Vessal et al., 2024</xref>; 
                <xref ref-type="bibr" rid="ref40">Sabel et al., 2016</xref>), little attention has been paid to pediatric cancer patients specifically.</p>
            <p>Integrating multisensory stimulation into healing environments has become transformative in healthcare settings (
                <xref ref-type="bibr" rid="ref35">Rezaee Vessal et al., 2024</xref>). For instance, 
                <xref ref-type="bibr" rid="ref11">Evans et al. (2021)</xref> emphasize the impact of sensory experiences on patients&#x2019; mental and physical well-being during care. Multisensory engagement offers pediatric cancer patients a meaningful escape from intrusive thoughts, supporting healing processes (
                <xref ref-type="bibr" rid="ref17">Helbling et al., 2024</xref>). Addressing these concerns requires healthcare providers to adopt a holistic approach that addresses the multifaceted needs of pediatric cancer patients and recognizes the multidimensional nature of the cancer experience (
                <xref ref-type="bibr" rid="ref8">Das, 2025</xref>; 
                <xref ref-type="bibr" rid="ref16">G&#x00f6;tte et al., 2022</xref>). Cancer patients need purposefully designed environments that foster safety and comfort without disrupting their physiological health (
                <xref ref-type="bibr" rid="ref5">Cheung et al., 2021</xref>).</p>
            <p>Therefore, in pediatric healthcare settings, multisensory design must meet the physiological, cognitive, and emotional needs of pediatric cancer patients. This study focuses particularly on pediatric cancer patients undergoing palliative care&#x2014;a vulnerable population whose physical and emotional capacities are often limited (
                <xref ref-type="bibr" rid="ref50">Vi&#x00f1;a et al., 2013</xref>). The study also adopts a sensitive and adaptive approach, ensuring minimal intrusion while prioritizing the child&#x2019;s comfort and well-being. Acknowledging potential difficulties in engaging pediatric participants, the study involves parental support for cross-validation of children&#x2019;s responses (
                <xref ref-type="bibr" rid="ref8">Das, 2025</xref>). Thus, this research advances architectural design principles by evaluating the sensory quality of touchpoints as active and affective healing environments critical to the well-being of pediatric cancer patients during care.</p>
        </sec>
        <sec id="sec6" sec-type="methods">
            <title>2. Method</title>
            <p>To investigate the emotional and sensory dimensions of healthcare environments, this study applies a hybrid multisensory mapping framework, combining insights from 
                <xref ref-type="bibr" rid="ref33">Ranne (2019)</xref> and 
                <xref ref-type="bibr" rid="ref43">Spence &amp; Gallace (2011)</xref>. While Ranne emphasizes user-experience-based sensory data and thematic evaluation, 
                <xref ref-type="bibr" rid="ref43">Spence &amp; Gallace (2011)</xref> provide a theoretical foundation for how multiple senses interact dynamically within space. The procedural steps of this hybrid framework are illustrated in 
                <xref ref-type="fig" rid="f1">
Figure 1</xref>, which presents the Multisensory Journey Mapping process applied in this study.</p>
            <fig fig-type="figure" id="f1" orientation="portrait" position="float">
                <label>
Figure 1. </label>
                <caption>
                    <title>Multisensory journey mapping steps.</title>
                </caption>
                <graphic id="gr1" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/196038/75daaac0-f68c-44a5-83a9-797232ff8c5a_figure1.gif"/>
            </fig>
            <p>

                <bold>Step 1: Contextual understanding</bold>
            </p>
            <p>The mapping begins by observing the built environment as a multisensory field (
                <xref ref-type="bibr" rid="ref43">Spence &amp; Gallace, 2011</xref>). Contextual understanding refers to the process of deeply grasping the broader setting, conditions, and lived experiences that shape the phenomenon under investigation (
                <xref ref-type="bibr" rid="ref3">Benca-Bachman et al., 2020</xref>). It involves mapping the entire sensory and spatial journey that pediatric cancer patients undertake&#x2014;from their point of departure (home or shelter), through transportation, hospital arrival, navigation of waiting areas and corridors, to the chemotherapy room, and finally back home. This process also explores which sensory elements matter most: what children see, hear, touch, smell, and emotionally respond to, and how these stimuli shape their feelings of comfort, curiosity, fear, or calm (
                <xref ref-type="bibr" rid="ref8">Das, 2025</xref>). Attention is also given to the social context&#x2014;who accompanies the child, their routines, and the emotional support available&#x2014;while identifying environmental affordances and constraints within each space (
                <xref ref-type="bibr" rid="ref5">Cheung et al., 2021</xref>; 
                <xref ref-type="bibr" rid="ref8">Das, 2025</xref>; 
                <xref ref-type="bibr" rid="ref41">Sereno et al., 2025</xref>). Psychological conditions were assessed using the Kessler Psychological Distress Scale (K10), along with an evaluation of each patient&#x2019;s physical condition prior to data collection. The assessment of physical status was conducted to ensure ethical readiness and to minimize risk during the study. In pediatric settings, physical condition assessments are often guided by clinical observation, including measurements of vital signs and general responsiveness, to evaluate the child&#x2019;s clinical stability before participation (
                <xref ref-type="bibr" rid="ref30">Parshuram et al., 2011</xref>). Grounded in these insights, contextual understanding provides a foundation for formulating meaningful research questions, selecting appropriate data collection methods, and generating interpretations that honor the lived experiences of vulnerable pediatric patients.</p>
            <p>

                <bold>Step 2: User journey definition</bold>
            </p>
            <p>A patient&#x2019;s or user&#x2019;s path through transitional hospital spaces&#x2014;from arrival to treatment or waiting rooms&#x2014;is traced and segmented. Key experiential nodes (e.g., entrances, corridor turns, waiting areas) are identified to capture moments of sensory intensity or transition (
                <xref ref-type="bibr" rid="ref33">Ranne, 2019</xref>; 
                <xref ref-type="bibr" rid="ref43">Spence &amp; Gallace, 2011</xref>). Spence and Gallace focus on thresholds and sequential experiences, which complement Ranne&#x2019;s stage-by-stage observational approach.</p>
            <p>

                <bold>Step 3: Sensory data collection</bold>
            </p>
            <p>To enrich these observations, the researcher directly engages with patients by asking what they see, feel, and sense at various points along their journey. These interactions are guided by a pre-prepared semi-structured interview list, which includes age-appropriate prompts designed to elicit children&#x2019;s perceptions in their own words. Given the vulnerability of the participants, all interviews are adapted to each child&#x2019;s comfort level and are supported by informal cross-checks with parents or guardians&#x2014;especially when verbal expression is limited. This dual method allows the researcher to capture both observable behaviors and subjective sensory impressions, resulting in a nuanced, experience-driven dataset that reflects how pediatric patients perceive and emotionally respond to the environments they encounter. The data collected in this study include both environmental sensory cues and children&#x2019;s subjective responses across different stages of their healthcare journey. Each spatial point is evaluated through multisensory logging: sound levels, material textures, lighting atmosphere, air quality, and olfactory presence are recorded. Sensory walkthroughs and observational notes are used to document these elements qualitatively (
                <xref ref-type="bibr" rid="ref33">Ranne, 2019</xref>; 
                <xref ref-type="bibr" rid="ref43">Spence &amp; Gallace, 2011</xref>).</p>
            <p>

                <bold>Step 4: Theme categorization</bold>
            </p>
            <p>Sensory data are organized into experience-based themes such as novelty, coherence, control, stimulation, and comfort (
                <xref ref-type="bibr" rid="ref33">Ranne, 2019</xref>). These themes help interpret the emotional tone of each spatial moment. This research adapts 
                <xref ref-type="bibr" rid="ref26">Mehrabian and Russell&#x2019;s (1974)</xref> theory, using the Pleasure, Arousal, Dominance (PAD) model as a foundational tool for categorizing emotional themes.</p>
            <p>

                <bold>Step 5: Mapping sensory flow and cross-modal interactions</bold>
            </p>
            <p>The sensory stimuli are mapped spatially and temporally, showing how they unfold across the user journey. Particular attention is paid to crossmodal interactions, for instance, how soft materials reduce acoustic harshness or how warm lighting mitigates visual anxiety (
                <xref ref-type="bibr" rid="ref43">Spence &amp; Gallace, 2011</xref>).</p>
            <p>

                <bold>Step 6: Assessing coherence and emotional friction</bold>
            </p>
            <p>This phase evaluates whether the multisensory environment functions in harmony (coherence) or generates tension and confusion (sensory friction). Mismatched cues, such as cold lighting paired with loud noise&#x2014;may heighten emotional discomfort or anxiety (
                <xref ref-type="bibr" rid="ref33">Ranne, 2019</xref>; 
                <xref ref-type="bibr" rid="ref43">Spence &amp; Gallace, 2011</xref>).</p>
            <p>

                <bold>Step 7: Reflective interpretation and design implications</bold>
            </p>
            <p>The final analysis interprets how the multisensory journey influences users&#x2019; emotional states, memory formation, and behavioral readiness. These insights form the basis for design recommendations, particularly in transitional spaces where emotional modulation is critical (
                <xref ref-type="bibr" rid="ref33">Ranne, 2019</xref>; 
                <xref ref-type="bibr" rid="ref43">Spence &amp; Gallace, 2011</xref>). This study utilized a qualitative, exploratory research approach within an interpretivist paradigm to examine the multisensory experiences of pediatric cancer patients during their hospital journey. Before participation, physical and psychological assessments were conducted to ensure participants&#x2019; readiness (
                <xref ref-type="bibr" rid="ref27">Miller et al., 2011</xref>; 
                <xref ref-type="bibr" rid="ref28">Nielsen et al., 2018</xref>). These assessments were performed and provided by the attending doctors and psychologists. Psychological assessments were conducted by a licensed psychologist using the Kessler Psychological Distress Scale (K10), a validated 10-item questionnaire that measures general distress based on anxiety and depressive symptoms experienced over the past four weeks. Participants (with caregiver assistance if needed) responded to each item using a Likert scale. The total score indicated levels of distress, helping determine emotional readiness for participation. Only children deemed both physically and psychologically fit were involved in the experimental sessions. Based on these evaluations, 24 pediatric cancer patients were selected for the study, as they met the necessary health criteria to participate safely in the research. Additionally, the Lansky Play-Performance Scale (LPPS) was employed to assess functional performance, with play activities rated by parents serving as indicators of the child&#x2019;s functional status (
                <xref ref-type="bibr" rid="ref34">Reeve et al., 2020</xref>).</p>
            <sec id="sec7">
                <title>2.1 Data collection</title>
                <p>Data collection was conducted through questionnaires and user observations. The questionnaires provided structured insights into emotional responses (
                    <xref ref-type="bibr" rid="ref7">Creswell &amp; Miller, 2000</xref>), while user observations documented behavioral cues and emotional reactions in real-time hospital journeys and environments (
                    <xref ref-type="bibr" rid="ref33">Ranne, 2019</xref>). The collected data were analyzed using thematic analysis, identifying key factors affecting the pediatric patient experience, such as environmental attractiveness, coherence of sensory elements, and emotional responses. A new systematic method for mapping multisensory information in hospital settings was developed, providing a tool for designers and healthcare providers to enhance the patient journey. Ethical considerations included obtaining informed consent from both children and their guardians, anonymizing data, and demonstrating sensitivity toward participants&#x2019; emotional states.</p>
            </sec>
            <sec id="sec8">
                <title>2.2 Participant</title>
                <p>The main participants of the study were pediatric cancer patients undergoing palliative care at the One Day Care Therapy facility at X Hospital in Surabaya. The study focused on children aged 5&#x2013;12 years, who were considered capable of expressing their sensory and emotional experiences both verbally and nonverbally. Adolescent and young adult patients were excluded due to significant differences in cognitive developmental stages and spatial perception. Only pediatric cancer patients without eye disorders were included. All participants were in stable health conditions, receiving care in the One Day Care Therapy Room, and had been recommended by a physician. All participants were enrolled following a structured three-stage informed consent procedure. First, the hospital team conducted an initial review to identify eligible pediatric cancer patients whose medical and psychological conditions were stable and appropriate for the study, and granted approval for their inclusion. Second, the observation procedures were explained in clear, age-appropriate language to both the children and their parents/guardians, after which verbal confirmation was obtained from the parents/guardians regarding their willingness to allow participation. Finally, the guardians signed a written informed consent form as official confirmation of their permission for their child&#x2019;s involvement in the study, while verbal assent was obtained from the children. Thus, all procedures were conducted in compliance with ethical standards for research involving human subjects, and all participant identities and data were treated with strict confidentiality in accordance with applicable regulations.</p>
            </sec>
            <sec id="sec9">
                <title>2.3 Ethical approval</title>
                <p>This study was conducted in accordance with the ethical principles outlined in the Declaration of Helsinki. Ethical approval for all study protocols was obtained from the Health Research Ethics Committee of RSUD Dr. Soetomo Surabaya, Indonesia, under approval number 0666/KEPK/V/2023. RSUD Dr. Soetomo served as the institution where data collection was carried out among patients receiving treatment, and the research adhered to the hospital&#x2019;s institutional regulations as well as international ethical standards. The observation procedures were explained in clear, age-appropriate language to both the children and their parents/guardians, after which verbal confirmation was obtained from the parents/guardians regarding their willingness to allow participation. The guardians signed a written informed consent form as official confirmation of their permission for their child&#x2019;s involvement in the study, while verbal assent was obtained from the children. All data were handled with strict confidentiality and used solely for research purposes.</p>
            </sec>
        </sec>
        <sec id="sec10" sec-type="result|discussion">
            <title>3. Result and discussion</title>
            <p>This section presents the key findings derived from the empirical investigation into the multisensory experiences of pediatric cancer patients throughout their hospital journey. Using a qualitative, exploratory approach, the study integrates observational data, patient interviews, and environmental sensory mapping to reveal how children emotionally and sensorially engage with hospital spaces. The analysis is structured into several sub-sections: contextual understanding, user journey definition, sensory data collection, and emotional theme categorization. These components collectively offer a deeper insight into how spatial and sensory stimuli influence pediatric patients&#x2019; emotional well-being, informing design considerations for more supportive healthcare environments.</p>
            <sec id="sec11">
                <title>3.1 Contextual understanding</title>
                <p>The contextual mapping revealed that pediatric cancer patients experienced a wide range of emotional and sensory responses across different stages of their treatment journey. By following the patients from their point of departure (home or shelter), through transportation, hospital entry, and ultimately back home, the research uncovered key spatial and temporal touchpoints that significantly shaped their psychological and sensory experiences. Based on interviews with psychologists involving 24 participants, it was found that most participants did not experience significant distress. The patients&#x2019; current stress levels remained within a normal and manageable range. Although a few participants exhibited higher distress scores compared to others, these levels were still considered tolerable. Overall, all participants demonstrated adequate social support from parents and family, which helped foster enthusiasm in their daily activities.</p>
                <p>However, in relation to their cancer diagnosis, only eight participants showed distress with a moderately elevated risk, and only one participant was found to have a moderately high stress level. The remaining participants generally did not display significant emotional distress. On average, their emotional expressions manifested as frustration or tantrums in response to unfulfilled desires, particularly during the early stages of chemotherapy when patients were required to undergo intensive treatment procedures. Emotional volatility at this stage was commonly triggered by the demanding nature of the treatments. Parental, familial, and peer support also played an essential role in regulating emotional responses. Regarding the patient experience during chemotherapy, participants generally paid more attention to details during the journey to the hospital and reported enjoying that part of the experience. In contrast, feelings of anxiety were more commonly expressed upon arrival at the hospital. In conclusion, the majority of pediatric cancer patients involved in this study were categorized as having low stress levels. Variations in stress appeared to be correlated with both the stage of treatment and the severity of illness experienced by the patients.</p>
            </sec>
            <sec id="sec12">
                <title>3.2 User journey definition</title>
                <p>The second step in this research is defining the user journey, which involves identifying and interpreting the journey of pediatric cancer patients as they navigate to, through, and from the hospital environment. This step aims to go beyond surface-level observations by exploring how patients experience each stage of their journey emotionally and sensorially. The patient journey was segmented into three phases: before hospital arrival, during spatial navigation within hospital premises, and after treatment or consultation (
                    <xref ref-type="bibr" rid="ref33">Ranne, 2019</xref>). Each phase outlined the patient&#x2019;s actions, sensory perceptions, and dominant sensory modalities based on empirical data triangulated with thematic analysis and relevant literature (
                    <xref ref-type="bibr" rid="ref14">Gibson, 1996</xref>; 
                    <xref ref-type="bibr" rid="ref51">Whitehead et al., 2016</xref>).</p>
            </sec>
            <sec id="sec13">
                <title>3.3 Data sensory collection</title>
                <p>The third step in this research involves sensory data collection, carried out through a combination of direct, non-intrusive observation and structured environmental scanning along the pediatric patient&#x2019;s entire treatment journey. The researcher follows the same spatial path experienced by the children from their home or shelter, during transport, entering the hospital, navigating waiting areas and corridors, undergoing treatment, and returning, while documenting multisensory stimuli in each segment. Observations focus on what patients visually capture and respond to, including lighting, color schemes, signage, spatial openness, and social interactions. In addition to visual elements, attention is given to auditory cues (e.g., ambient sounds, voices, machinery), tactile sensations (e.g., textures, temperature), olfactory inputs (e.g., antiseptics, food, outside air), and the general emotional tone of each space.</p>
                <p>Data analysis follows a thematic and spatial mapping approach. First, responses are transcribed and coded to identify recurring emotional and sensory themes such as calmness, anxiety, curiosity, or discomfort, linked to specific sensory inputs (e.g., loud noise, dim light, cold surfaces). Using tools from qualitative content analysis, these codes are grouped into categories (e.g., sensory coherence, overstimulation, emotional readiness). Simultaneously, data are plotted visually using multisensory journey maps to spatially trace how sensory experiences shift along the treatment path. By overlaying environmental features with emotional reactions, the analysis reveals which areas and stimuli contribute positively or negatively to the patient&#x2019;s well-being. This integrated method, combining thematic analysis with visual-spatial mapping, enables the researcher to interpret how architecture and sensory conditions shape children&#x2019;s emotional states, supporting evidence-based design recommendations.</p>
            </sec>
            <sec id="sec14">
                <title>3.4 Theme categorization</title>
                <p>To interpret pediatric patients&#x2019; emotional responses to multisensory environments, this study applied the PAD model as an analytical lens rather than a descriptive framework. Patients&#x2019; verbal expressions, supported by observed facial and bodily cues, were mapped onto PAD dimensions to capture how environmental stimuli shaped emotional activation and perceived control. Rather than treating emotions as isolated reactions, this approach enabled the identification of affective patterns across the care journey, particularly in transitional spaces. As such, PAD mapping functioned as an interpretive bridge between multisensory experience and emotional regulation, allowing environmental influences on pediatric well-being to be examined holistically. For example, children who described their journey as &#x201c;interesting,&#x201d; &#x201c;safe,&#x201d; or &#x201c;nice&#x201d; may be interpreted as experiencing high pleasure and low arousal, placing their emotional response in the serene quadrant of the PAD matrix. Conversely, when children described their journey as &#x201c;noisy,&#x201d; &#x201c;confusing,&#x201d; or &#x201c;scary,&#x201d; these responses may fall under high arousal and low pleasure, indicating a stressful or overwhelming experience. The detailed mapping of patient statements into the PAD model quadrants is presented in 
                    <xref ref-type="table" rid="T1">
Table 1</xref>, which illustrates how verbal expressions were systematically categorized.</p>
                <table-wrap id="T1" orientation="portrait" position="float">
                    <label>
Table 1. </label>
                    <caption>
                        <title>Mapping of patient statements.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Quadrant</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">
Mapping patient feel</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="11" valign="top">Arousing - Pleasant</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Interesting</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Love it</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Wow</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Can't wait</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Fun</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Like</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Pretty</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Cool</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Amazing</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Happy</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Nice</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="8" valign="top">Pleasant - Not Arousing</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Safe</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Yes</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Better</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Quite</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Every sentence or statement is added with the suffix "sih" (Indonesian)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Restful</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Tidy</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Comfort</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="8" valign="top">Unpleasant - Not Arousing</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Don&#x2019; know</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Ya</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Usual</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Kind of</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Just like</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Fair</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Bearable</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Decent</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="10" valign="top">Unpleasant - Arousing</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">So so</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Hectic</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Dont like</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Hate it</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Aargh</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Uncomfortable</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Scare</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">I don&#x2019;t want to</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Noisy</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Stop</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <p>In PAD theory, there are quadrants of affective response based on human reactions to the environment. Patients&#x2019; perceptions of the environment can be positioned within these quadrants. The researcher attempts to map the words expressed by the patients into the appropriate PAD quadrant, while also cross-referencing their facial expressions and body language with the verbal statements they made. Patients&#x2019; feelings can be interpreted through their choice of words. To assess patients&#x2019; emotional states, this study considers their verbal expressions, as the specific words they choose often reflect their inner feelings and psychological responses (
                    <xref ref-type="bibr" rid="ref25">Mehrabian, 1996</xref>).</p>
                <p>Prior to visualization, patients&#x2019; verbal emotional expressions were systematically analyzed using the PAD framework. Each verbal expression was coded according to PAD valence criteria (Pleasure/Displeasure &#x00d7; Arousal/Non-Arousal) based on the operational definitions proposed by 
                    <xref ref-type="bibr" rid="ref26">Mehrabian and Russell (1974)</xref>. The coding process involved categorizing expressions into affective states by considering both emotional valence and activation level. For instance, expressions such as &#x201c;happy,&#x201d; &#x201c;delighted,&#x201d; and &#x201c;exciting&#x201d; were mapped to the Pleasure&#x2013;Arousal quadrant, whereas expressions such as &#x201c;anxious&#x201d; and &#x201c;afraid&#x201d; were mapped to the Displeasure&#x2013;Arousal quadrant, and expressions such as &#x201c;tired&#x201d; and &#x201c;relieved&#x201d; were mapped to the Pleasure&#x2013;Non-Arousal quadrant. Following this coding procedure, the categorized expressions were plotted within the PAD quadrants to visualize the dominant emotional tendencies of each patient group. The resulting distributions provide a comparative representation of emotional patterns between patients with low and high stress levels, while the size of each plotted point reflects the frequency of the corresponding emotional response.</p>
                <p>Based on the identified multisensory journey, pediatric cancer patients with low stress levels were found to fall within the Pleasure and Arousal quadrants of the PAD model, as shown in 
                    <xref ref-type="fig" rid="f2">
Figure 2</xref>. According to the data, the larger the circle, the greater the number of patients who expressed and exhibited the corresponding emotional response. In contrast, patients with high stress levels were found to fall within the Displeasure and Non-Arousal quadrants, as illustrated in 
                    <xref ref-type="fig" rid="f3">
Figure 3</xref>.</p>
                <fig fig-type="figure" id="f2" orientation="portrait" position="float">
                    <label>
Figure 2. </label>
                    <caption>
                        <title>PAD quadrants of patients during chemotherapy for those with low stress levels.</title>
                    </caption>
                    <graphic id="gr2" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/196038/75daaac0-f68c-44a5-83a9-797232ff8c5a_figure2.gif"/>
                </fig>
                <fig fig-type="figure" id="f3" orientation="portrait" position="float">
                    <label>
Figure 3. </label>
                    <caption>
                        <title>PAD quadrants of patients during chemotherapy for those with high stress levels.</title>
                    </caption>
                    <graphic id="gr3" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/196038/75daaac0-f68c-44a5-83a9-797232ff8c5a_figure3.gif"/>
                </fig>
                <p>Based on the analysis of the multisensory journey and its relation to the PAD model, it can be concluded that sensory environments significantly influence the emotional responses of pediatric cancer patients. Patients with low stress levels tended to associate their experiences with environments that induced feelings of pleasure and arousal&#x2014;characterized by calmness, curiosity, and emotional engagement&#x2014;indicating a more positive and responsive interaction with their surroundings. This was reflected in the higher frequency of positive words and corresponding facial expressions. Conversely, patients experiencing high stress were predominantly mapped within the Displeasure and Non-Arousal quadrants, revealing emotional states marked by withdrawal, discomfort, and a lack of engagement. These contrasting patterns suggest that the design of sensory-rich, emotionally supportive environments plays a critical role in shaping psychological outcomes for pediatric patients during treatment.</p>
            </sec>
            <sec id="sec15">
                <title>3.5 Mapping sensory flow and cross-modal interactions</title>
                <p>This study categorizes participants into two distinct stress-level groups, low and high, based on observed behavioral and emotional indicators during the chemotherapy process. The categorization emerged from an emic approach, in which the researcher directly accompanied pediatric patients during treatment, allowing for immersive and context-sensitive observations. Of the 24 patients involved, 8 were identified as experiencing high stress and 16 as experiencing low stress. These groupings formed the analytical framework for examining variations in their multisensory experiences throughout the treatment journey.
                    <list list-type="order">
                        <list-item>
                            <label>1.</label>
                            <p>Multisensory journey map for lower level of stress paediatric cancer patients</p>
                        </list-item>
                    </list>
                </p>
                <p>Qualitative data were coded thematically across five sensory modalities, such as, visual, auditory, haptic, olfactory, and gustatory&#x2014;along with affective-emotional responses (
                    <xref ref-type="bibr" rid="ref33">Ranne, 2019</xref>). This framework revealed that children did not experience the hospital as a singular place but rather as a succession of interconnected sensory environments, each with the potential to either soothe or heighten emotional stress (see 
                    <xref ref-type="fig" rid="f4">
Figure 4</xref>). Consistent with 
                    <xref ref-type="bibr" rid="ref29">Pallasmaa&#x2019;s (2024)</xref> phenomenological approach to architecture, the child&#x2019;s body was understood as a site of multisensory interpretation and meaning-making, where emotion arises not in abstraction but through embodied interaction with spatial and sensory cues.</p>
                <fig fig-type="figure" id="f4" orientation="portrait" position="float">
                    <label>
Figure 4. </label>
                    <caption>
                        <title>The multisensory user journey map.</title>
                        <p>Notes: The left column (steps 1-19) describes different phases of the momentary UX, affecting the sensation column presenting the current feeling of the user, and the upper column divides sensations based on Gibson&#x2019;s perceptual system (
                            <xref ref-type="bibr" rid="ref15">1987</xref>). The building column explains how the system reacts to the user and the notes column further explains the choices.</p>
                    </caption>
                    <graphic id="gr4" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/196038/75daaac0-f68c-44a5-83a9-797232ff8c5a_figure4.gif"/>
                </fig>
                <p>For instance, visually, engaging signage, colorful furnishings, and the presence of play materials contributed to distraction and cognitive engagement, providing children with a sense of control over unfamiliar surroundings (
                    <xref ref-type="bibr" rid="ref9">Devlin &amp; Arneill, 2003</xref>). Auditory experiences, including gentle background music and familiar voices, acted as emotional anchors, helping children navigate transitions between emotionally charged zones such as treatment rooms and waiting areas. Tactile experiences&#x2014;such as plush seating or soft furnishings&#x2014;were consistently mentioned or observed as sources of comfort, buffering anxiety related to clinical procedures (
                    <xref ref-type="bibr" rid="ref24">Malchiodi, 2008</xref>). Even olfactory stimuli, often overlooked in clinical design, played a critical role: the scent of antiseptics was sometimes balanced by the smell of books, familiar food, or ambient fragrances, evoking a sense of normalcy and grounding (
                    <xref ref-type="bibr" rid="ref18">Herz et al., 2004</xref>).</p>
                <p>The qualitative evidence thus suggests that sensory coherence&#x2014;defined as the predictable, integrative, and emotionally attuned alignment of sensory inputs across different hospital zones&#x2014;is essential in supporting emotional resilience. Emotional trajectories captured during this study often began with excitement or curiosity, dipped into mild anxiety during clinical interventions, and then returned to states of calm or relief. These dynamic affective patterns affirm the importance of designing hospital journeys as multisensory and emotionally intelligent experiences. This sensory mapping extended beyond clinical environments to include transitional spaces such as car rides to the hospital, waiting areas, corridors, and recovery zones. Drawing from the concept of transitional space in healthcare design (
                    <xref ref-type="bibr" rid="ref45">Suddick et al., 2021</xref>), these zones serve as psychological and physiological buffers between different phases of the care experience. When designed with sensory responsiveness in mind, they facilitate orientation, mitigate fear, and support emotional continuity. High-tier design strategies must therefore view hospital spaces not as isolated rooms but as parts of a continuous sensory-emotional journey that children must navigate.</p>
                <p>Following the descriptive mapping of hospital journeys experienced by children with lower stress levels, this section offers a thematic interpretation of the data. Utilizing a sensory-emotional lens grounded in environmental psychology and healthcare design literature, the analysis was structured around six interrelated sensory domains: emotional/affective, visual, auditory, tactile, olfactory/gustatory, and environmental-spatial. These categories emerged inductively through a reflexive thematic analysis (
                    <xref ref-type="bibr" rid="ref4">Braun &amp; Clarke, 2006</xref>), shaped by direct observation, participatory fieldwork, and interpretive engagement with multisensory experiences. Each theme reflects how children navigated their hospital environments emotionally and physiologically, revealing how supportive environmental design can mitigate distress and promote emotional resilience.
                    <list list-type="order">
                        <list-item>
                            <label>2.</label>
                            <p>Multisensory journey map for higher level of stress paediatric cancer patients</p>
                        </list-item>
                    </list>
                </p>
                <p>The multisensory journey mapping of pediatric cancer patients with high stress levels reveals environments marked by sensory fragmentation, emotional dissonance, and a lack of responsive design (see 
                    <xref ref-type="fig" rid="f5">
Figure 5</xref>). These children navigated hospital visits not through comfort, but through survival strategies, enduring unpredictable, overstimulating, or barren settings that heightened their distress. Emotional states such as fear, disorientation, and helplessness were most intense during pre-treatment transitions and medical interventions and were exacerbated by the absence of emotionally attuned stimuli.</p>
                <fig fig-type="figure" id="f5" orientation="portrait" position="float">
                    <label>
Figure 5. </label>
                    <caption>
                        <title>The multisensory user journey map for high level of stress based on Gibson&#x2019;s perceptual system (
                            <xref ref-type="bibr" rid="ref14">1996</xref>).</title>
                    </caption>
                    <graphic id="gr5" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/196038/75daaac0-f68c-44a5-83a9-797232ff8c5a_figure5.gif"/>
                </fig>
                <p>Visual inputs were often described as dim, monotonous, or sterile, lacking child-friendly features such as color, narrative artwork, or spatial landmarks. Auditory environments were dominated by clinical sounds&#x2014;beeping machines, abrupt staff conversations, and ambient hallway noise&#x2014;with no counterbalance in the form of soothing music or nature-based soundscapes. This sensory imbalance aligns with findings by 
                    <xref ref-type="bibr" rid="ref6">Coyne et al. (2016)</xref> and 
                    <xref ref-type="bibr" rid="ref47">Ulrich et al. (2008)</xref>, who demonstrate that unregulated or monotonous environments in pediatric settings can amplify anxiety and reduce emotional coping capacity. Tactile experiences further contributed to the children&#x2019;s stress. Cold surfaces, hard chairs, and repeated painful procedures (e.g., IV insertions) offered no comforting haptic counterpoints. Without access to soft or familiar textures, children had limited physical grounding. Similarly, olfactory stimuli&#x2014;predominantly antiseptic and medicinal&#x2014;triggered strong aversive reactions, particularly in children undergoing repeated chemotherapy. As 
                    <xref ref-type="bibr" rid="ref18">Herz et al. (2004)</xref> emphasizes, negative olfactory memories can anchor traumatic associations and intensify anticipatory fear.</p>
                <p>While some calming features were present, such as soft lighting and ergonomic seating, these elements were static, impersonal, and uniformly applied, failing to respond to children&#x2019;s evolving emotional needs. This underscores the limitations of one-size-fits-all design in pediatric care. As noted by 
                    <xref ref-type="bibr" rid="ref24">Malchiodi (2008)</xref>, pediatric spaces must dynamically adapt to individual emotional rhythms, integrating multisensory cues that offer orientation, distraction, and comfort. Without such interventions, the journey becomes not only physically taxing but emotionally disintegrating. These findings suggest a critical need for trauma-sensitive, multisensory design frameworks in pediatric oncology environments&#x2014;frameworks that not only accommodate medical function but also actively engage with the child&#x2019;s sensory world to reduce fear, restore agency, and promote emotional resilience.</p>
            </sec>
            <sec id="sec16">
                <title>3.6 Assessing coherence and emotional friction</title>
                <p>In this study, assessing coherence and emotional friction revealed how the alignment or lack thereof between environmental stimuli and patient perception significantly influenced pediatric cancer patients&#x2019; emotional responses throughout their healthcare journey. For patients experiencing a lower level of stress, a sense of coherence emerged when sensory inputs such as lighting, sound, texture, and spatial rhythm were consistent and predictable, creating feelings of safety, curiosity, and emotional readiness. Conversely, high-stress patients frequently experienced emotional friction, especially in transitional areas, where inconsistent sensory cues, abrupt spatial changes, or overwhelming stimuli disrupted their emotional equilibrium. These frictions manifested as discomfort, anxiety, and psychological resistance, particularly when entering unfamiliar or overstimulating spaces.</p>
                <p>By mapping these moments across the journey from home to hospital and back, this research underscores that emotional friction often arises not from the clinical procedure itself, but from poorly integrated or disjointed sensory and spatial experiences. Thus, emotional coherence is not only a psychological state but an architectural outcome, reinforcing the necessity for sensory-informed, empathetic design in pediatric healthcare settings. The final thematic domain integrates the physical-spatial structure of the hospital environment. The overall spatial sequence&#x2014;home, vehicle, entrance, waiting, treatment, recovery, and departure&#x2014;was characterized by coherent design logic. Transitions between spaces were marked by consistent lighting, flooring, color palettes, and signage, allowing children to predict and adapt to new environments without disorientation. Here is the explanation of the coherence of each sensory modality in relation to the patient&#x2019;s journey.
                    <list list-type="order">
                        <list-item>
                            <label>1.</label>
                            <p>Visual Engagement: Color, Light, and Active Distraction</p>
                        </list-item>
                    </list>
                </p>
                <p>The visual environment consistently lacked the narrative, symbolic, and playful elements necessary for pediatric engagement. Dimly lit corridors, monochrome walls, and sparse decoration characterized transitional areas. Children noted the &#x201c;dark hallway,&#x201d; &#x201c;boring walls,&#x201d; or &#x201c;no fun things here&#x201d; when moving between spaces. Even in treatment rooms, the visual landscape was described in utilitarian terms, with minimal color, artistic cues, or spatial zoning to differentiate one stage of care from another. Visual stimuli played a fundamental role in shaping how children interpreted their environments. The presence of vibrant colors, thematic murals, interactive displays, and visibility of play areas transformed otherwise passive or anxiety-inducing spaces into zones of active engagement. These features functioned as more than decorative elements; they redirected attention away from clinical stressors and toward child-friendly narratives. This corresponds with 
                    <xref ref-type="bibr" rid="ref9">Devlin and Arneill&#x2019;s (2003)</xref> findings that environmental color and design in pediatric settings can modulate anxiety levels by promoting a sense of familiarity and welcome. In particular, the transition areas&#x2014;waiting rooms, corridors, and entrances&#x2014;benefited from visually engaging features that served as transitional markers and emotional buffers. The findings also reflect 
                    <xref ref-type="bibr" rid="ref1">Batchelor et al. (2023)</xref>, who emphasize the role of environmental art in creating zones of positive distraction, aiding emotional resilience during uncertain or stressful moments.
                    <list list-type="order">
                        <list-item>
                            <label>2.</label>
                            <p>Sound as Emotional Infrastructure: Auditory Anchors and Sensory Continuity</p>
                        </list-item>
                    </list>
                </p>
                <p>Sound played a paradoxical role throughout the children&#x2019;s hospital journey&#x2014;both omnipresent and emotionally destabilizing. In clinical zones, beeping monitors, echoing footsteps, abrupt medical conversations, and mechanical noises dominated the auditory environment. These sounds were rarely balanced by calming or intentional auditory design, often leaving children overstimulated or unsettled. They frequently described these areas as &#x201c;noisy,&#x201d; &#x201c;too loud,&#x201d; or filled with &#x201c;lots of machine sounds,&#x201d; which often coincided with visible signs of distress or requests for distraction tools. 
                    <xref ref-type="bibr" rid="ref35">Rezaee Vessal et al. (2024)</xref> emphasize that unmanaged hospital soundscapes can act as emotional stressors, particularly for pediatric patients with limited contextual understanding. The absence of modulated auditory inputs such as soft music, nature sounds, or child-friendly tones meant that clinical spaces lacked the sensory relief necessary for emotional regulation. In contrast, auditory experience was not merely passive but central to children&#x2019;s emotional navigation and spatial orientation.</p>
                <p>Interestingly, during the journey to the hospital, sound was often interpreted more positively. Children who traveled by ambulance found enjoyment in the siren, a sound that, while loud, was perceived as meaningful and exciting, functioning as a form of positive distraction. Similarly, children who departed from home or shelters expressed pleasure in listening to music or engaging in conversations with parents during the trip. The journey itself&#x2014;filled with familiar street views, people, and dynamic soundscapes&#x2014;provided sensory continuity and a buffer before entering the clinical environment. These auditory elements helped reduce perceptual gaps across spatial transitions and reinforced a sense of emotional coherence and orientation.
                    <list list-type="order">
                        <list-item>
                            <label>3.</label>
                            <p>Haptic Comfort: Touch as Grounding and Reassurance</p>
                        </list-item>
                    </list>
                </p>
                <p>Tactile experiences played a powerful yet often overlooked role in how children coped with medical environments. Materials such as soft seating, fuzzy blankets, familiar toys, and rounded furnishings offered a sense of normalcy and embodied comfort. These haptic cues helped mitigate the intrusiveness of cold instruments, sterile furniture, and the tactile invasiveness of medical procedures. 
                    <xref ref-type="bibr" rid="ref24">Malchiodi (2008)</xref> emphasizes that tactile engagement&#x2014;especially with comforting or familiar textures&#x2014;can promote emotional self-regulation in pediatric patients, particularly during moments of uncertainty, pain, or sensory overload. In this study, children were often observed seeking tactile constancy. For instance, the presence of a personal item, such as a pillow or stuffed animal, served as a mobile source of sensory stability across different spaces. Children with both low and high levels of stress expressed increased haptic sensitivity throughout the journey. They often described sensations of cold&#x2014;weather from the air-conditioned transport, metal furniture, or vinyl seats&#x2014;as unpleasant and discomforting. Interestingly, during the chemotherapy process, several children reported feeling warm or sweaty shortly after the medication was administered, a physiological reaction to the treatment that further highlights the importance of recognizing real-time changes in haptic perception.</p>
                <p>When touch is unmediated by comfort or control, it becomes a source of heightened vulnerability. Children frequently referenced pain or discomfort, saying &#x201c;the needle hurts,&#x201d; &#x201c;cold chair,&#x201d; or &#x201c;I don&#x2019;t want to be touched,&#x201d; revealing the predominance of aversive tactile encounters in certain zones. The treatment rooms, in particular, lacked haptic counterbalances such as plush textures, weighted comfort tools, or soft fabrics that might have helped ground children emotionally. As 
                    <xref ref-type="bibr" rid="ref24">Malchiodi (2008)</xref> asserts, the haptic domain carries therapeutic potential when intentionally integrated into trauma-sensitive care. Its absence deprived children of one of the most intuitive and immediate sensory pathways to emotional regulation&#x2014;especially critical during medical interventions or emotional distress.
                    <list list-type="order">
                        <list-item>
                            <label>4.</label>
                            <p>Smell and Taste: Olfactory Anchoring and Emotional Memory</p>
                        </list-item>
                    </list>
                </p>
                <p>Olfactory and gustatory inputs, though less consciously perceived than visual or auditory stimuli, played a subtle yet emotionally resonant role throughout the pediatric patients&#x2019; journeys. The sensory environment was largely dominated by antiseptic, medicinal, and chemical scents&#x2014;aromas that children frequently associated with discomfort or fear. Comments such as &#x201c;it smells like medicine,&#x201d; &#x201c;I don&#x2019;t like the hospital smell,&#x201d; or &#x201c;gross&#x201d; were common, especially in treatment zones and corridors. 
                    <xref ref-type="bibr" rid="ref18">Herz et al. (2004)</xref> emphasizes that scent is deeply linked to emotional memory and can act as a powerful, often subconscious trigger of affective states. In this context, the predominance of negative olfactory cues often served as a sensory &#x201c;primer,&#x201d; activating emotional tension even before clinical procedures began.</p>
                <p>Interestingly, children did not always spontaneously recognize or report olfactory input during interviews. The researcher often needed to prompt or recall their awareness of smell. Once prompted, many children showed clear preferences, particularly for pleasant scents such as vanilla or food brought from home. This aligns with 
                    <xref ref-type="bibr" rid="ref18">Herz et al. (2004)</xref> findings on the emotionally anchoring effect of familiar scents. In more public or transitional areas, such as waiting rooms or near hospital caf&#x00e9;s, the occasional presence of ambient odors like food, sweet perfumes, or even scented books created a subtle olfactory layering effect. These non-clinical scents allowed children to emotionally tether themselves to positive associations, offering brief moments of sensory relief amid the dominant hospital aroma.</p>
                <p>Mapping the multisensory journeys of pediatric cancer patients under high stress reveals a clear pattern of emotional disorientation and sensory overload. Unlike children experiencing a lower level of stress who benefited from consistent and emotionally supportive spatial environments, high-stress patients encountered unpredictable and often aversive sensory inputs. These inconsistencies were not isolated events but rather cumulative disruptions, triggering emotional, behavioral, and physiological distress across multiple phases of care. In the early transition stages of the hospital experience (Steps 1&#x2013;5), children expressed fear, anxiety, and avoidance. Verbal statements such as &#x201c;I&#x2019;m scared to go to the hospital&#x201d; were reinforced by nonverbal cues&#x2014;averted gaze, physical withdrawal, or tightly gripping caregivers&#x2014;all signaling a reduced sense of agency and heightened emotional arousal. As treatment progressed (Steps 6&#x2013;14), these reactions often escalated into ambivalence and emotional detachment. Many children showed passive compliance, distraction-seeking, or withdrawal, suggesting a reduced capacity for self-regulation in the face of ongoing environmental stressors. These observations align with 
                    <xref ref-type="bibr" rid="ref6">Coyne et al. (2016)</xref> findings that children in clinical settings frequently experience a profound loss of control, particularly during unfamiliar or painful procedures. Emotional insecurity is further intensified by a child&#x2019;s inability to anticipate what will happen next&#x2014;a critical component of psychological safety in pediatric care (
                    <xref ref-type="bibr" rid="ref47">Ulrich et al., 2008</xref>).</p>
                <p>Although many hospital spaces include conventional child-friendly features such as ergonomic furniture, soft lighting, and muted color palettes, these elements were often standardized and failed to respond to the children&#x2019;s shifting emotional states. Descriptions like &#x201c;same everywhere,&#x201d; &#x201c;just another room,&#x201d; or &#x201c;calming but boring&#x201d; illustrate that these environments lacked personal relevance and failed to offer meaningful orientation or relief. The repetitive sensory scripts across different areas created a sense of monotony, deepening emotional disconnection instead of reducing distress. This design uniformity limited the environment&#x2019;s ability to act as an emotional anchor. In contrast to settings that adapt dynamically to sensory and psychological needs, these standardized environments reinforced feelings of being lost or emotionally unsupported, especially among children under high stress.</p>
                <p>A synthesis of findings across all six sensory domains&#x2014;visual, auditory, tactile, olfactory, gustatory, and spatial rhythm&#x2014;shows that positive, low-stress patient journeys are not accidental. Instead, they are actively shaped through coherent, predictable, and emotionally attuned sensory design. When sensory cues such as light, sound, touch, and smell are harmonized across spatial transitions, children feel more oriented, emotionally stable, and psychologically prepared, even when facing unfamiliar or invasive procedures. In conclusion, these insights support a growing body of evidence emphasizing the importance of sensory integration in pediatric healthcare design (
                    <xref ref-type="bibr" rid="ref24">Malchiodi, 2008</xref>; 
                    <xref ref-type="bibr" rid="ref43">Spence &amp; Gallace, 2011</xref>). Aligning sensory coherence with emotional regulation offers a critical framework for embedding sensory intelligence into pediatric environments, making them not only clinically effective but also emotionally resilient.</p>
            </sec>
            <sec id="sec17">
                <title>3.7 Reflective interpretation and design implications</title>
                <p>In the final phase of this research, the multisensory and emotional data collected from pediatric cancer patients were synthesized through reflective interpretation to identify patterns and meanings behind their experiences. This step not only deepens the understanding of how sensory stimuli influence emotional responses but also bridges the gap between empirical findings and practical architectural interventions. The following discussion outlines the key interpretive insights and translates them into actionable design recommendations tailored to pediatric healthcare settings.</p>
                <p>This study&#x2019;s findings indicate that pediatric cancer patients perceive healthcare spaces as emotionally charged, multisensory environments rather than neutral backdrops for treatment. Each stage of the journey&#x2014;from home, through hospital spaces, to the chemotherapy room&#x2014;elicits distinct emotional responses shaped by environmental stimuli such as lighting, sound, smell, and spatial transitions. For children experiencing a lower level of stress, a consistent and coherent sensory environment fostered emotional regulation, curiosity, and comfort. In contrast, children in the high-stress group often encountered sensory incoherence, abrupt spatial changes, or overstimulating transitions, which led to emotional friction manifested as anxiety, discomfort, or psychological withdrawal. These outcomes support existing research highlighting the importance of multisensory coherence in reducing stress and promoting well-being in clinical environments (
                    <xref ref-type="bibr" rid="ref20">Kipps &amp; Erdman, 2025</xref>; 
                    <xref ref-type="bibr" rid="ref35">Rezaee Vessal et al., 2024</xref>). This reflective analysis underscores that emotional reactions in pediatric patients often arise not from clinical procedures themselves, but from how environments are perceived and experienced through the senses (
                    <xref ref-type="bibr" rid="ref43">Spence &amp; Gallace, 2011</xref>).</p>
                <p>The implications for architectural design are both practical and urgent. Transitional spaces such as corridors, waiting rooms, and entrances&#x2014;often overlooked in conventional planning&#x2014;should be reimagined as therapeutic thresholds that prepare and support children emotionally. Research shows that these areas can significantly affect psychological readiness and overall experience (
                    <xref ref-type="bibr" rid="ref1">Batchelor et al., 2023</xref>). To that end, spatial design should prioritize sensory consistency, clarity of navigation, and child-scaled features to provide a sense of control and reduce uncertainty. The use of positive distractions, such as interactive visual displays, calming acoustics, and natural light, aligns with 
                    <xref ref-type="bibr" rid="ref46">Ulrich&#x2019;s (1991)</xref> theory of supportive design and has been shown to mitigate distress in pediatric care. These insights call for a paradigm shift in pediatric healthcare design: from clinically efficient to emotionally intelligent environments.</p>
            </sec>
        </sec>
        <sec id="sec18">
            <title>4. Conclusion, limitation, and future research</title>
            <p>This study aimed to explore how pediatric cancer patients perceive and emotionally respond to their healthcare journey through a multisensory lens. Specifically, it sought to map sensory stimuli across transitional spaces and examine their impact on patients&#x2019; emotional states, psychological readiness, and overall well-being. Through a qualitative, exploratory approach grounded in an interpretivist paradigm, the research revealed that pediatric patients do not experience hospitals as neutral settings but rather as emotionally charged environments shaped by visual, auditory, tactile, olfactory, and spatial cues.</p>
            <p>The findings demonstrate that patients with low stress levels tend to associate their healthcare journey with environments that offer sensory coherence&#x2014;predictable and emotionally attuned sensory inputs&#x2014;which in turn foster calmness, curiosity, and emotional engagement. In contrast, high-stress patients often encounter fragmented and overstimulating sensory environments, particularly in transitional zones, leading to emotional friction manifested as anxiety, discomfort, and psychological withdrawal. This study underscores that pediatric healthcare environments must not only fulfill clinical functions but also serve as supportive emotional landscapes. Design interventions that incorporate sensory integration&#x2014;such as consistent lighting, calming acoustics, familiar textures, and positive distractions&#x2014;have the potential to mitigate distress and enhance emotional resilience. Ultimately, the study calls for a shift from clinically efficient to emotionally intelligent hospital design, particularly for vulnerable populations such as pediatric cancer patients. While sensory experiences may vary across hospital architectures, cultural norms, and treatment protocols, the underlying principle of sensory coherence&#x2014;namely, the alignment and predictability of multisensory cues in shaping emotional responses&#x2014;remains broadly applicable across pediatric healthcare settings. As such, the findings offer transferable conceptual insights that can inform emotionally supportive hospital design beyond the specific institutional and cultural context of this study.</p>
            <p>Several limitations should be acknowledged. First, the study was conducted with a relatively small sample of 24 pediatric cancer patients aged 5&#x2013;12 at a single hospital, which limits the generalizability of the findings. Second, due to the emic and context-sensitive nature of the methodology, data collection was heavily reliant on the researcher&#x2019;s direct observations and interpretations, which may introduce subjectivity and observational bias. Third, the assessment of emotional responses was based largely on verbal and non-verbal cues rather than objective physiological measures, which may not fully capture the complexity of children&#x2019;s emotional states. Future research should expand to include older age groups, such as adolescents and young adults, to explore differences in sensory perception and spatial cognition across developmental stages. Longitudinal studies could investigate how repeated exposure to hospital environments influences emotional adaptation over time. Employing mixed-methods designs that incorporate quantitative tools&#x2014;such as biometric sensors or eye-tracking technology&#x2014;could provide more robust and objective insights into patients&#x2019; sensory-emotional experiences. Additionally, interdisciplinary collaboration among healthcare professionals, environmental psychologists, and designers is recommended to develop evidence-based, multisensory design frameworks that prioritize psychological well-being in pediatric healthcare settings.</p>
        </sec>
    </body>
    <back>
        <sec id="sec21" sec-type="data-availability">
            <title>Data availability</title>
            <p>Zenodo. Anonymized dataset of pediatric patient profiles and statements categorized using the PAD model. 
                <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.5281/zenodo.17120706">https://doi.org/10.5281/zenodo.17120706</ext-link>. 
                <xref ref-type="bibr" rid="ref38">Rucitra, A. A. (2025a)</xref>
            </p>
            <p>This project contains the following underlying data:
                <list list-type="bullet">
                    <list-item>
                        <label>&#x2022;</label>
                        <p>Profile of participants &#x2013; consisting of anonymized codes, age, weight, height, type of disease, disease level, and level of stress. All identifiers have been removed to ensure anonymity.</p>
                    </list-item>
                    <list-item>
                        <label>&#x2022;</label>
                        <p>Patient statements dataset &#x2013; anonymized responses from pediatric patients, categorized using the PAD (Pleasure, Arousal, Dominance) model. These responses represent verbal expressions and perceptions of healthcare environments and served as the basis for the emotional and sensory analysis conducted in the study.</p>
                    </list-item>
                    <list-item>
                        <label>&#x2022;</label>
                        <p>All data and extended materials are available under the terms of the 
                            <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International</ext-link> (CC BY 4.0) license.</p>
                    </list-item>
                </list>
            </p>
            <p>Zenodo. Extended Data: Interview Guide for Mapping Multisensory Journeys in Pediatric Oncology Care. 
                <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.5281/zenodo.17120762">https://doi.org/10.5281/zenodo.17120762</ext-link>. 
                <xref ref-type="bibr" rid="ref39">Rucitra, A. A. (2025b)</xref>
            </p>
            <p>This project contains the following extended data:
                <list list-type="bullet">
                    <list-item>
                        <label>&#x2022;</label>
                        <p>Interview Guide &#x2013; a structured set of open-ended, age-appropriate questions designed to capture pediatric patients&#x2019; sensory perceptions, emotional responses, and experiences within oncology care environments. The guide ensured consistency across data collection while allowing flexibility for participants and caregivers to share their perspectives in their own words.</p>
                    </list-item>
                </list>
            </p>
            <p>All data and extended materials are available under the terms of the 
                <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International</ext-link> (CC BY 4.0) license.</p>
        </sec>
        <ack>
            <title>Acknowledgement</title>
            <p>The authors would like to thank the Department of Architecture, Institut Teknologi Sepuluh Nopember, Surabaya, for facilitating the entire study process. We are truly grateful for their invaluable support.</p>
        </ack>
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    <sub-article article-type="reviewer-report" id="report426148">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.185822.r426148</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Ratwita Andarsini</surname>
                        <given-names>Mia</given-names>
                    </name>
                    <xref ref-type="aff" rid="r426148a1">1</xref>
                    <role>Referee</role>
                </contrib>
                <aff id="r426148a1">
                    <label>1</label>Universitas Airlangga, Surabaya, Indonesia</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>24</day>
                <month>11</month>
                <year>2025</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2025 Ratwita Andarsini M</copyright-statement>
                <copyright-year>2025</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport426148" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.168632.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>The manuscript 
                <italic>&#x201c;</italic>
                <italic>Mapping Multisensory Journeys in Pediatric Oncology Care: Toward Emotionally Intelligent Healthcare Environments&#x201d;</italic> addresses an important and underexplored area the sensory emotional experiences of pediatric oncology patients across their treatment journey. The topic is timely, relevant, and well aligned with current directions in patient-centered and sensory-responsive healthcare design. The manuscript is generally well written, methodologically grounded, and offers valuable insights for healthcare designers, clinicians, and researchers.</p>
            <p> I recommend 
                <bold>minor revision</bold> to strengthen conceptual clarity, methodological transparency, and figure/structure consistency. The required improvements do not alter the core study but will substantially enhance scientific rigor and readability.</p>
            <p> &#x00a0; 
                <list list-type="order">
                    <list-item>
                        <p>
                            <bold>Improve Flow in the Results&#x2013;Discussion Section</bold> 
                            <list list-type="bullet">
                                <list-item>
                                    <p>Some paragraphs repeat theoretical citations that appear in the Introduction. Compress repetitive references to strengthen narrative flow.</p>
                                </list-item>
                            </list> </p>
                    </list-item>
                </list> 
                <bold>2. Consistency of Terminology</bold>
            </p>
            <p> Please standardize recurring terms: 
                <list list-type="bullet">
                    <list-item>
                        <p>&#x201c;multisensory journey mapping&#x201d; vs. &#x201c;sensory journey mapping&#x201d;</p>
                    </list-item>
                    <list-item>
                        <p>&#x201c;low stress group&#x201d; vs. &#x201c;lower level of stress&#x201d;</p>
                    </list-item>
                    <list-item>
                        <p>&#x201c;pediatric cancer patients&#x201d; vs. &#x201c;pediatric oncology patients&#x201d;</p>
                    </list-item>
                </list> 
                <bold>3. Check Grammar and Typographical Issues</bold>
            </p>
            <p> Minor edits will improve clarity (examples): 
                <list list-type="bullet">
                    <list-item>
                        <p>&#x201c;Preety&#x201d; &#x2192; &#x201c;Pretty&#x201d;</p>
                    </list-item>
                    <list-item>
                        <p>Some long sentences may benefit from segmentation for readability.</p>
                    </list-item>
                </list> 
                <bold>4. Provide Clearer Explanation of Figures 2 and 3 (PAD Quadrants)</bold>
            </p>
            <p> Figures 2 and 3 show circles indicating patient distribution in PAD quadrants, but the manuscript does not explicitly explain: 
                <list list-type="bullet">
                    <list-item>
                        <p>how verbal expressions were converted to points in quadrants,</p>
                    </list-item>
                    <list-item>
                        <p>whether mapping was done manually or through a coding framework.</p>
                    </list-item>
                </list> 
                <bold>Required revision:</bold>
            </p>
            <p> </p>
            <p> Add a short explanatory sentence such as: 
                <list list-type="bullet">
                    <list-item>
                        <p>&#x201c;Each verbal expression was coded according to PAD valence criteria (Pleasure/Displeasure &#x00d7; Arousal/Non-Arousal) using the definitions provided in Mehrabian &amp; Russell (1974). These coded expressions were then plotted to visualize the emotional tendency of each group.&#x201d;</p>
                    </list-item>
                </list> 
                <bold>5. CONCLUSION &#x2013; Add One Sentence Addressing Transferability</bold>
            </p>
            <p> The conclusion is strong but does not discuss the transferability of findings across hospitals or cultural contexts.</p>
            <p> 
                <bold>Required revision:</bold>
            </p>
            <p> Add 1&#x2013;2 sentences acknowledging that: 
                <list list-type="bullet">
                    <list-item>
                        <p>sensory experiences may differ across hospital architectures, cultural norms, or treatment protocols</p>
                    </list-item>
                    <list-item>
                        <p>but the underlying principle of sensory coherence is broadly applicable</p>
                    </list-item>
                </list>
            </p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Yes</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Yes</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Yes</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Yes</p>
            <p>Reviewer Expertise:</p>
            <p>Pediatric oncology</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.</p>
        </body>
        <sub-article article-type="response" id="comment15372-426148">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Rucitra</surname>
                            <given-names>Anggra Ayu</given-names>
                        </name>
                        <aff>Department of Architecture, Not Applicable, Surabaya, Indonesia</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>31</day>
                    <month>1</month>
                    <year>2026</year>
                </pub-date>
            </front-stub>
            <body>
                <p>This revised manuscript improves conceptual clarity, methodological transparency, and readability in response to reviewer feedback. The Results&#x2013;Discussion section was streamlined by reducing repetitive theoretical citations already introduced in the Introduction and emphasizing data-driven interpretation. Terminology was standardized throughout the manuscript to ensure consistency in references to multisensory journey mapping, stress-level groupings, and pediatric oncology patients. Minor grammatical and typographical issues were corrected, and long sentences were refined for clarity.</p>
                <p> Methodological transparency was enhanced through the addition of a concise explanation describing how patients&#x2019; verbal expressions were coded and mapped onto the PAD (Pleasure&#x2013;Arousal&#x2013;Dominance) quadrants in Figures 2 and 3 using established valence criteria. Finally, the Conclusion was expanded to acknowledge contextual variability across hospital settings and cultural environments while emphasizing the broader transferability of the principle of sensory coherence. These revisions strengthen the manuscript without altering its core findings.</p>
            </body>
        </sub-article>
    </sub-article>
</article>
