<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN" "http://jats.nlm.nih.gov/publishing/1.2/JATS-journalpublishing1.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="research-article" dtd-version="1.2" xml:lang="en">
    <front>
        <journal-meta>
            <journal-id journal-id-type="pmc">F1000Research</journal-id>
            <journal-title-group>
                <journal-title>F1000Research</journal-title>
            </journal-title-group>
            <issn pub-type="epub">2046-1402</issn>
            <publisher>
                <publisher-name>F1000 Research Limited</publisher-name>
                <publisher-loc>London, UK</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="doi">10.12688/f1000research.171712.3</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Research Article</subject>
                </subj-group>
                <subj-group>
                    <subject>Articles</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Typologies of suicidality and suicide presenting to a prehospital South African Emergency Medical Service: a retrospective cross-sectional analysis</article-title>
                <fn-group content-type="pub-status">
                    <fn>
                        <p>[version 3; peer review: 3 approved]</p>
                    </fn>
                </fn-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author" corresp="yes">
                    <name>
                        <surname>Tilley</surname>
                        <given-names>Daniel</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Project Administration</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0003-3598-9907</uri>
                    <xref ref-type="corresp" rid="c1">a</xref>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Christopher</surname>
                        <given-names>Lloyd Denzil</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Funding Acquisition</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-8072-7634</uri>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Farrar</surname>
                        <given-names>Thomas</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Funding Acquisition</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Software</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="aff" rid="a2">2</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Naidoo</surname>
                        <given-names>Navindhra</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Funding Acquisition</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0001-5261-0677</uri>
                    <xref ref-type="aff" rid="a1">1</xref>
                    <xref ref-type="aff" rid="a3">3</xref>
                </contrib>
                <aff id="a1">
                    <label>1</label>Emergency Medical Science, Faculty of Health and Wellness Sciences,Cape Peninsula University of Technology, Cape Town, Western Cape, South Africa</aff>
                <aff id="a2">
                    <label>2</label>Mathematics and Physics, Faculty of Applied Sciences, Cape Peninsula University of Technology, Cape Town, Western Cape, South Africa</aff>
                <aff id="a3">
                    <label>3</label>Paramedicine, School of Health sciences//Humanitarian and Development Research Initiative (HADRI)/Young and Resilient Research Centre, Institute for Culture and Society,: Western Sydney University; Legitimation Code Theory Centre for Knowledge Building: University of Sydney, New South Wales, Australia</aff>
            </contrib-group>
            <author-notes>
                <corresp id="c1">
                    <label>a</label>
                    <email xlink:href="mailto:danieltilley88@gmail.com">danieltilley88@gmail.com</email>
                </corresp>
                <fn fn-type="conflict">
                    <p>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>4</day>
                <month>3</month>
                <year>2026</year>
            </pub-date>
            <pub-date pub-type="collection">
                <year>2025</year>
            </pub-date>
            <volume>14</volume>
            <elocation-id>1201</elocation-id>
            <history>
                <date date-type="accepted">
                    <day>25</day>
                    <month>2</month>
                    <year>2026</year>
                </date>
            </history>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2026 Tilley D et al.</copyright-statement>
                <copyright-year>2026</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <self-uri content-type="pdf" xlink:href="https://f1000research.com/articles/14-1201/pdf"/>
            <abstract>
                <sec>
                    <title>Background</title>
                    <p>The global age-standardised suicide rate is estimated at 8.9/100 000, while South Africa is at an alarming 23.5/100 000. The prehospital Emergency Medical Services (EMS) is located within this burden of health need. Emergency Care providers have a duty to assess, treat and transport healthcare consumers with suicidality, when attending to the suicide-related caseload.</p>
                </sec>
                <sec>
                    <title>Aim</title>
                    <p>To appraise suicidality case frequency and suicide typology for the EMS.</p>
                </sec>
                <sec>
                    <title>Objectives</title>
                    <p>To estimate the scope of the suicidality challenge faced by a jurisdictional EMS and its care providers.</p>
                </sec>
                <sec>
                    <title>Methods</title>
                    <p>Using a retrospective cross-sectional design and a novel data collection instrument, a census of three years of Ambulance Incident Management Records was undertaken in a rural district of the Western Cape, South Africa.</p>
                </sec>
                <sec>
                    <title>Results</title>
                    <p>Of 413,712 records, 2,976 (N) mental health-related incidents were sampled. Fourteen percent (n = 412) were assessed to have descriptors of suicidal ideation (n = 227), attempted suicide (n = 83) or death by suicide (n = 102). There were, on average, 2.8 deaths by suicide per month over the 3-year study period in the Garden Route District. Women were reported to mostly ingest poison and overdose on medication, while men used asphyxiation/hanging and were 5 times more likely to die by suicide than women.</p>
                </sec>
                <sec>
                    <title>Conclusion</title>
                    <p>This study estimates the prehospital suicide and suicidality burden for the Western Cape public Emergency Medical Services, elucidating an under-researched health concern within South African prehospital care. Further study is required on the risk of emergency care provider stigmatisation towards suicide and suicidality cases, while auditing the need to assess policy, praxis, medical surveillance, EC provider clinical capacity and victim needs and experiences.</p>
                </sec>
            </abstract>
            <kwd-group kwd-group-type="author">
                <kwd>Suicide and Suicidality</kwd>
                <kwd>Typology</kwd>
                <kwd>Syndemic research</kwd>
                <kwd>Emergency Medical Service</kwd>
                <kwd>Paramedicine</kwd>
            </kwd-group>
            <funding-group>
                <funding-statement>The author(s) declared that no grants were involved in supporting this work.</funding-statement>
            </funding-group>
        </article-meta>
        <notes>
            <sec sec-type="version-changes">
                <label>Revised</label>
                <title>Amendments from Version 2</title>
                <p>Changes have been made to the abstract, adding aim and objectives. References have been rearranged and text has been made more concise throughout the document, as suggested by the reviewers. Materials and Methods section has had some rewording to describe the design and scenario for the research in better light as suggested by the reviewers. Strangulation Death has been changed to asphyxiation/hanging. Grammar and spelling has been reworked with consistency put towards acronyms and capitalization of words, as suggested by the reviewers. The discussion makes more inferences to age, as founded in the results and compares it to other research in LMICs, with Trauma Informed Care and Syndemic approach to suicide explained in better light. These concepts were removed from the conclusion and explained from an EMS perspective.&#x00a0; Limitations were included to incorporate misclassification bias. Two new references were added. All advice from the reviewers was taken into consideration and the manuscript was correct/amended as such.</p>
            </sec>
        </notes>
    </front>
    <body>
        <sec id="sec5">
            <title>Highlights
</title>
            <p>

                <list list-type="bullet">
                    <list-item>
                        <label>&#x2022;</label>
                        <p>There were, on average, 2.3 and 2.8 attempted suicides and deaths by suicide in the Garden Route District over the 3-year study period, respectively.</p>
                    </list-item>
                    <list-item>
                        <label>&#x2022;</label>
                        <p>Women were found to use poison or medication overdose in suicide, while men used asphyxiation/hanging, presenting 5 times more likely to succumb to suicide than women.</p>
                    </list-item>
                    <list-item>
                        <label>&#x2022;</label>
                        <p>Future research is needed into suicidality and suicide management, praxis, policy and stigmatisation of suicidality victims from a EMS perspective. Exploring trauma informed care and a syndemic approach to suicidality intervention and intersections with prehospital emergency care may enhance system responses.</p>
                    </list-item>
                </list>
            </p>
        </sec>
        <sec id="sec6" sec-type="intro">
            <title>Introduction</title>
            <p>Death by suicide in South Africa (SA) accounted for more insurance-related death claims than trauma, crime and motor vehicle accidents in 2024 (
                <xref ref-type="bibr" rid="ref4">Bhana, 2025</xref>). Globally, suicide accounted for 727 000 deaths in 2021-with an estimated 20 attempted suicides per suicide (
                <xref ref-type="bibr" rid="ref8">Caulkins, 2022</xref>)-greater mortality than war, homicide and HIV/AIDS. This equates to one suicide for every 100 deaths (
                <xref ref-type="bibr" rid="ref61">World Health Organization, 2025</xref>). The global age-standardised suicide rate in 2021 was estimated at 8.9 per 100 000, whereas the Africa region recorded 11.5 per 100 000. SA recorded 23.5 per 100 000 population, equating to almost 14 000 deaths by suicide per annum, placing SA third highest in suicide rates in Africa (
                <xref ref-type="bibr" rid="ref60">World Health Organization, 2024</xref>, 
                <xref ref-type="bibr" rid="ref61">2025</xref>). Significantly, suicide was the third leading cause of death amongst people aged 15-29, while globally, suicide ranked as the 21
                <sup>st</sup> leading cause of death in 2021 (
                <xref ref-type="bibr" rid="ref60">World Health Organization, 2024</xref>, 
                <xref ref-type="bibr" rid="ref61">2025</xref>). Suicide and suicidality have become a public health burden and an under-researched priority in low-and middle-income countries (LMICs) (
                <xref ref-type="bibr" rid="ref36">Pompili, 2022</xref>).</p>
            <p>SA endures a quadruple disease burden, the effects of which are compounded by poverty, crime and inequality (
                <xref ref-type="bibr" rid="ref2">Ataguba et al., 2015</xref>; 
                <xref ref-type="bibr" rid="ref7">Burns, 2011</xref>) while producing numerous societal-level socioeconomic risk factors for mental illness exacerbation (
                <xref ref-type="bibr" rid="ref30">Motsoaledi &amp; Matsoso, 2013</xref>). SA is deeply embedded in the social determinants of health, which indirectly affects the social determinants of mental health (
                <xref ref-type="bibr" rid="ref10">Compton &amp; Shim, 2017</xref>). Sixty three percent of South Africans live in poverty; 31.9% are unemployed (
                <xref ref-type="bibr" rid="ref51">The World Bank, 2024</xref>; 
                <xref ref-type="bibr" rid="ref57">World Bank Group, 2020</xref>); a rape case is estimated to take place every 12 minutes (
                <xref ref-type="bibr" rid="ref1">Action Society, 2024</xref>; 
                <xref ref-type="bibr" rid="ref11">Egenasi et al., 2024</xref>; 
                <xref ref-type="bibr" rid="ref16">Gass et al., 2010</xref>); 86 murders, 88 attempted murders and 595 assault cases are reported to happen daily (
                <xref ref-type="bibr" rid="ref37">Prinsloo et al., 2022</xref>) and 18.9% of the population abuse alcohol and/or drugs (
                <xref ref-type="bibr" rid="ref31">Myers et al., 2022</xref>). These nuanced social constructs are all social antecedents for suicidality and suicide by aiding in the exacerbation of poor mental health, expediting pathways to suicidality.</p>
            <p>Deinstitutionalisation through the Mental Health Care Act 17 of 2002 provided no compensatory mental health care community service or prioritisation of mental health through a health care plan at a provincial level (
                <xref ref-type="bibr" rid="ref7">Burns, 2011</xref>; 
                <xref ref-type="bibr" rid="ref25">Lund et al., 2011</xref>, 
                <xref ref-type="bibr" rid="ref26">2012</xref>). Thus, EMS is 
                <italic toggle="yes">de facto</italic> relied upon as a primary health care point for all poor mental health sequalae and related emergencies (
                <xref ref-type="bibr" rid="ref52">Tilley, 2021</xref>; 
                <xref ref-type="bibr" rid="ref55">Van Huyssteen, 2016</xref>). Notably, SA has multi-cultural challenges which can aggravate the need for urgent western mental health care (
                <xref ref-type="bibr" rid="ref20">Kirmayer, 2022</xref>; 
                <xref ref-type="bibr" rid="ref22">Kootbodien et al., 2020</xref>; 
                <xref ref-type="bibr" rid="ref27">Maharajh &amp; Abdool, 2005</xref>; 
                <xref ref-type="bibr" rid="ref30">Motsoaledi &amp; Matsoso, 2013</xref>), and complicate health seeking behaviour further. This suggests that all South African prehospital Emergency Care (EC) Providers are required to assess, treat and transport mental healthcare consumers with suicidality by navigating their social determinants of mental health while experiencing a mental health treatment gap. The lack of mental healthcare consumer compliance is further compounded by the loss of trained EC providers, psychologists, psychiatrists and mental healthcare providers (
                <xref ref-type="bibr" rid="ref3">Bateman, 2015</xref>; 
                <xref ref-type="bibr" rid="ref7">Burns, 2011</xref>; 
                <xref ref-type="bibr" rid="ref19">Jacob &amp; Coetzee, 2018</xref>; 
                <xref ref-type="bibr" rid="ref28">Majiet et al., 2025</xref>).</p>
            <p>
                <xref ref-type="bibr" rid="ref8">Caulkins (2022)</xref> posits that suicide is looked at as &#x2018;
                <italic toggle="yes">syndemic&#x2019;</italic>, rather than syndromic, and illuminates intersectionality as an interdisciplinary technique to advance further understanding of suicidality behaviours (
                <xref ref-type="bibr" rid="ref8">Caulkins, 2022</xref>). Syndemic theory elucidates how combining cultural factors and two or more physiological factors manifests a public health challenge and builds on the social determinants of health theory (
                <xref ref-type="bibr" rid="ref8">Caulkins, 2022</xref>). Considering syndemic theory as a theoretical lens for system level responses to suicide may have value for manifesting suicidality awareness from an African/LMIC perspective, notwithstanding that research on suicide and suicidality has low reporting rates in Africa (
                <xref ref-type="bibr" rid="ref61">World Health Organization, 2025</xref>) and is poorly represented in prehospital emergency care research.</p>
            <p>There is limited empirical evidence describing suicidality typology in the South African prehospital EMS research. By appraising suicidality typology and epidemiologically descriptive evidence, the scope of the concern for the prehospital space becomes apparent. This has the potential to influence the building of suicidality capacity and knowledge for EC provider praxis. Thus, the question that arises is: What is the typology of suicidality within the prehospital, rural EMS context? The aim was to appraise suicidality case frequency and suicide typology for the EMS with the objectives being to estimate the scope of the suicidality challenge faced by a jurisdictional EMS and its care providers.</p>
        </sec>
        <sec id="sec7">
            <title>Materials and methods</title>
            <sec id="sec8">
                <title>Design</title>
                <p>Focusing on healthcare consumers with mental health needs was the pivot for this study. Coherent with a critical theory paradigm (
                    <xref ref-type="bibr" rid="ref63">Naidoo, 2011</xref>), a retrospective cross-sectional observational design, with quantitative analysis was used. Data were extracted from the Western Cape Department of Health and Wellness public Emergency Medical Services (WCEMS) healthcare consumers&#x2019; Incident Management Records (IMR) from the Garden Route District, Western Cape (South Africa) from 2017 to 2019 (3 years). A census (100% sample) was taken of IMRs in the WCEMS database that met the study&#x2019;s inclusion criteria based on incident type. The dataset thus consisted of archival data related to healthcare consumers needing ambulance transport to a psychiatric facility, having psychiatric challenges, overdosed, self-harmed or died by suicide. &#x2018;Died by suicide&#x2019; was defined as a prehospital service category and not as a forensic confirmation.</p>
                <p>These incident types are recorded in the EMS database as &#x2018;Self-Harm-other&#x2019;, &#x2018;Self-Harm-poisoning&#x2019;, &#x2018;Psychiatric/Behavioural Problems&#x2019; and &#x2018;Inter-facility transfer (IFT)-psychiatric/behavioural problem&#x2019; (
                    <xref ref-type="bibr" rid="ref54">Tilley et al., 2023</xref>). A census of these incident types included all EMS IMR from 2017 to 2019. IMRs associated with accidental poisoning of children under 8 years were excluded. IMRs are created by emergency call-takers and emergency ambulance dispatchers for every healthcare consumer who requires the WCEMS and is the property of the WCEMS Emergency Communications Centre (
                    <xref ref-type="bibr" rid="ref52">Tilley, 2021</xref>; 
                    <xref ref-type="bibr" rid="ref54">Tilley et al., 2023</xref>). Notably, emergency call-takers and emergency ambulance dispatchers are not mental health care professionals and rely on senior medical advice, caller descriptive prompts and confirmation of healthcare consumer triage from senior EC providers arriving on scene.</p>
            </sec>
            <sec id="sec9">
                <title>Study setting and population</title>
                <p>The study site was the rural Garden Route District, one of six district municipalities in the Western Cape. The Garden Route District comprises of seven local municipalities that experience poor socioeconomic conditions (
                    <xref ref-type="bibr" rid="ref54">Tilley et al., 2023</xref>; 
                    <xref ref-type="bibr" rid="ref56">Western Cape Government, 2019</xref>). The census approach identified a total of 413 712 IMRs from health care consumer interactions between 2017 and 2019; of these, 2 976 (N) met the incident type inclusion criteria. Of the 2 976 IMRs included in the dataset, 412 (n) healthcare consumers presented with suicidal ideation (thoughts of death), attempted suicide (having attempted death), and death by suicide (having died). Considering the vernacular, it is notable that an emergency caller would describe a healthcare consumer as &#x2018;having thoughts of death&#x2019; (suicidal ideation), &#x2018;having tried to kill oneself&#x2019; (attempting suicide) or &#x2018;taken their own life&#x2019; (death by suicide) to emergency call takers when calling for help. We provide this sub-group analysis here.</p>
            </sec>
            <sec id="sec10">
                <title>Data analysis</title>
                <p>Binary and multinomial logistic regression, Pearson&#x2019;s Chi-squared test of independence, Fisher&#x2019;s Exact Test, Analysis of Variance (ANOVA), and Tukey&#x2019;s Honest Significant Difference (HSD) method were used to illuminate associations of interest among attempted suicide and suicide victims. Data was analysed in R statistical software (
                    <xref ref-type="bibr" rid="ref38">R Core Team, 2025</xref>). Logistic regression allowed for analysis of relationships between a categorical dependent variable and one or more independent (predictor) variables, which could be categorical (Gender) or numerical (Age). If the dependent variable is binary (e.g., Suicide or No Suicide), the model predicts the probability of the binary outcome using a log-odds link function (
                    <xref ref-type="bibr" rid="ref49">Sperandei, 2014</xref>). A multinomial logistic regression model can be used if the dependent variable has more than two categories (e.g., method of [attempted] suicide). The model coefficient(s) p-value of a significance test indicates probable relationships between dependent and predictor variables, usually expressed as an expected odds ratio. Pearson&#x2019;s Chi-square test of independence tests whether two categorical variables have any association (
                    <xref ref-type="bibr" rid="ref5">Bolboac&#x0103; et al., 2011</xref>). The null hypothesis (H
                    <sub>0</sub>) states &#x2018;there is no association between two variables while the alternative hypothesis (H
                    <sub>a</sub>) states, there is an association between two variables (
                    <xref ref-type="bibr" rid="ref5">Bolboac&#x0103; et al., 2011</xref>, p. 530). Fisher&#x2019;s Exact Test is another method for testing for an association between categorical variables, but unlike Pearson&#x2019;s test, it does not rely on an asymptotic null distribution and thus the required assumptions are weaker (
                    <xref ref-type="bibr" rid="ref5">Bolboac&#x0103; et al., 2011</xref>; 
                    <xref ref-type="bibr" rid="ref33">Nowacki, 2017</xref>). In the case of binary variables, one can use Fisher&#x2019;s Exact Test to test for a directional alternative (i.e., a positive or negative association); (
                    <xref ref-type="bibr" rid="ref15">Freeman &amp; Campbell, 2007</xref>; 
                    <xref ref-type="bibr" rid="ref33">Nowacki, 2017</xref>). For all hypothesis tests, we used a significance level of 0.05, meaning that if the 
                    <italic toggle="yes">p</italic>-value was less than 0.05, we rejected the null hypothesis; otherwise, the null hypothesis was retained (
                    <xref ref-type="bibr" rid="ref5">Bolboac&#x0103; et al., 2011</xref>; 
                    <xref ref-type="bibr" rid="ref33">Nowacki, 2017</xref>).</p>
                <p>A multinomial logistic regression model, ANOVA and Tukey&#x2019;s HSD method were used to find smaller associations between gender, age and method of attempted suicide or suicide. ANOVA is used to show differences between two or more groups through significance tests, making comparisons between populations (
                    <xref ref-type="bibr" rid="ref18">Hosmer &amp; Lemeshow, 2000</xref>; 
                    <xref ref-type="bibr" rid="ref46">Sawyer, 2009</xref>). The ANOVA test compares variation between sample means and variation within each of the samples. Low p-values are indications of compelling evidence against the null hypothesis that the group means are all equal. Tukey&#x2019;s HSD method is based on a studentized range statistic and is used in connection with ANOVA as a post hoc method to identify pairwise significant differences, since the ANOVA test is an omnibus test that only identifies the presence or absence of differences in mean between treatments (
                    <xref ref-type="bibr" rid="ref17">Hilton, 2006</xref>). Tukey&#x2019;s method is designed to control the familywise type I error rate at a fixed level (e.g., 0.05) despite the large number of pairwise comparisons being made.</p>
            </sec>
            <sec id="sec11">
                <title>Consent</title>
                <p>A waiver of informed consent for a retrospective study was granted by an institutional ethics committee 
                    <italic toggle="yes">(CPUT/HW-REC 2019/H17)</italic>, duly registered by the National Health Research Ethics Committee, as it was not practicable to obtain individual consent. Access to the Western Cape National Health Research Database 
                    <italic toggle="yes">(WC_201911_033)</italic> was granted by the provincial health department. There are adequate safeguards for participant privacy as all retrospective data were de-identified and there were no human participants engaged with during the data analysis.</p>
            </sec>
        </sec>
        <sec id="sec12" sec-type="results">
            <title>Results</title>
            <p>Over the 3-year period of sampled healthcare consumers who presented to the WCEMS, 14% (n = 412) presented with suicidality and death by suicide, while 63% (n = 1890) presented with mental illness sequela, considered stereotypical mental illness antecedents associated with deaths by suicide (
                <xref ref-type="bibr" rid="ref23">Ku&#x0142;ak-Bejda et al., 2021</xref>). These were 
                <italic toggle="yes">overdose/DSP, substance abuse, depression, anxiety, self-harm, bipolar disorder, schizophrenia</italic> and 
                <italic toggle="yes">PTSD</italic> (
                <xref ref-type="table" rid="T1">
Table 1</xref>). There were, on average 2.8 deaths by suicide (n = 102) and 2.3 attempted suicides (n = 83) per month in the Garden Route District between 2017 and 2019. Gender and age associations were used to illuminate the suicidality and the death by suicide case load burden that EC providers from the WCEMS face. Prehospital EC providers were expected to respond to 412 (n) suicidality and death by suicide healthcare consumers from the census population of 2 976 (N) emergencies over the 3-year period (
                <xref ref-type="bibr" rid="ref53">Tilley, 2025</xref>).</p>
            <table-wrap id="T1" orientation="portrait" position="float">
                <label>
Table 1. </label>
                <caption>
                    <title>Emergency Medical Service (EMS) Mental Illness typology.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1" valign="top">Category</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Frequency (n)</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">
Relative frequency (%)</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Overdose/DSP</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1550 (n)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">52%</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Suicidal Ideation</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">227 (n)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">7.6%</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Substance Abuse</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">108 (n)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.6%</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Suicide</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">102 (n)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3.4%</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Depression</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">89 (n)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3%</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Attempted Suicide</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">83 (n)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2.7%</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Anxiety</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">59 (n)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2%</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Cutting Self-Harm
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">41 (n)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1.3%</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Bipolar Disorder</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">21 (n)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.7%</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Schizophrenia</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">19 (n)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.6%</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Post-traumatic stress disorder</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3 (n)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.1%</td>
                        </tr>
                    </tbody>
                </table>
                <table-wrap-foot>
                    <p>
                        <xref ref-type="table" rid="T1">
Table 1</xref> presents the counts of health care consumers with mental illness sequela that presented to the Western Cape Government Emergency Medical Services (WCGEMS) over a 3-year period (2017-2019). Using R statistical software, analysis found that Fourteen percent (n = 412) presented with suicidality and death by suicide, while sixty three percent (n = 1890) presented with mental illness sequela from the census population of 2 976 (N) emergencies over the 3-year period. There were, on average 2.8 deaths by suicide (n = 102) and 2.3 attempted suicides (n = 83) per month in the Garden Route District between 2017 and 2019. This typology consisted of 
                        <italic toggle="yes">Overdose/Deliberate Self-Poison (DSP); Suicidal Ideation; Substance Abuse; Suicide; Depression; Attempted Suicide; Anxiety; Cutting Self-Harm; Bipolar Disorder; Schizophrenia</italic> and 
                        <italic toggle="yes">Post-traumatic stress disorder (PTSD).</italic>
                    </p>
                </table-wrap-foot>
            </table-wrap>
            <sec id="sec13">
                <title>&#x2018;Death by Suicide Typology&#x2019;</title>
                <p>&#x2018;Death by Suicide&#x2019; was detected in 102 (n) of 2976 (N), suggesting 34 deaths by suicide per year of the study period. Death by suicide was defined by types of method, namely, 
                    <italic toggle="yes">&#x2018;Asphyxiation/hanging&#x2019;, &#x2018;Overdose/DSP&#x2019;, &#x2018;jump from height&#x2019;, &#x2018;Gunshot&#x2019;</italic> and 
                    <italic toggle="yes">&#x2018;Cutting Self-Harm&#x2019;</italic> (
                    <xref ref-type="table" rid="T2">
Table 2</xref>). These cases precede postmortem and are service categories of the prehospital EMS and not that of the forensic pathologist.</p>
                <table-wrap id="T2" orientation="portrait" position="float">
                    <label>
Table 2. </label>
                    <caption>
                        <title>Frequency of method per Death by Suicide and Attempted Suicide.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Method</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Death by Suicide (n)</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">
Attempted Suicide (n)</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Asphyxiation/hanging</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">82 (n)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">51 (n)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Overdose/DSP</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">11 (n)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">11 (n)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Jump
                                    <xref ref-type="table-fn" rid="tfn1">*</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4 (n)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2 (n)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Cutting Self-Harm
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1 (n)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">5 (n)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Gunshot</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1 (n)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0 (n)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Unspecified</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0 (n)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">8 (n)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Parasuicidal</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0 (n)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">6 (n)</td>
                            </tr>
                        </tbody>
                    </table>
                    <table-wrap-foot>
                        <p>
                            <xref ref-type="table" rid="T2">
Table 2</xref> presents the counts of health care consumers from the 3-year study period (2017-2019) who died by suicide and attempted suicide. From 2 976 (N) emergencies in the census sample, 102 (n) health care consumers died by suicide and 83 (n) attempted suicide. The methods that were used were 
                            <italic toggle="yes">Strangulation (asphyxiation); Overdose/Deliberate Self-Poison; Jump from heigh</italic> and 
                            <italic toggle="yes">jump from moving vehicle; Cutting Self-Harm; Gunshot; Unspecified method</italic> and 
                            <italic toggle="yes">Parasuicidal.</italic>
</p>
                        <p>Death by Suicide caseload precedes postmortem and are service categories of the prehospital Emergency Medical Services and not that of the forensic pathologist.</p>
                        <fn-group content-type="footnotes">
                            <fn id="tfn1">
                                <label>*</label>
                                <p>Jump refers to &#x201c;jump from height&#x201d; for death by suicide victims and &#x201c;jump from moving car&#x201d; for attempted suicide victims.</p>
                            </fn>
                        </fn-group>
                    </table-wrap-foot>
                </table-wrap>
            </sec>
            <sec id="sec14">
                <title>&#x2018;Attempted Suicide Typology&#x2019;</title>
                <p>&#x2018;Attempted Suicide&#x2019; was detected in 83 (n) of 2976 (N), suggesting 27 attempted suicides per year of the study period (
                    <xref ref-type="bibr" rid="ref54">Tilley et al., 2023</xref>). The types of methods that are defined as attempted suicide are 
                    <italic toggle="yes">&#x2018;Asphyxiation/hanging&#x2019;, &#x2018;Overdose/DSP&#x2019;, &#x2018;jump from moving vehicle&#x2019;, &#x2018;Cutting Self-Harm&#x2019;, &#x2018;Parasuicidal&#x2019;</italic> (attempted suicide with no intention of death, dictated by repeated offences by the same healthcare consumer, flagged by consistent healthcare consumer pattern and labelled by authors) and 
                    <italic toggle="yes">&#x2018;Unspecified&#x2019;</italic> (
                    <xref ref-type="table" rid="T2">
Table 2</xref>).</p>
            </sec>
            <sec id="sec15">
                <title>Age and gender typology with Attempted Suicide and Death by Suicide</title>
                <p>Using a significance level of 
                    <italic toggle="yes">0.05</italic> throughout the study, gender, and age associations with &#x2018;death by suicide&#x2019; and &#x2018;attempted suicide&#x2019; provided further insight into this burden faced by prehospital EC providers working for the WCEMS. Logistic regression models, with age as the independent variable and &#x2018;attempted suicide&#x2019; and &#x2018;death by suicide&#x2019; as dependent variables, were run. Significantly, age was not a predictor of occurrence for &#x2018;death by suicide&#x2019; (
                    <italic toggle="yes">p = 0.3089</italic>) or &#x2018;attempted suicide&#x2019; (
                    <italic toggle="yes">p = 0.3095</italic>). However, the models were rerun with a quadratic age term to check for non-monotonic relationships. While there were still no significant effects in the &#x2018;attempted suicide&#x2019; model (
                    <italic toggle="yes">p</italic> = 0.577 on the quadratic term), in the &#x2018;death by suicide&#x2019; model, both the linear (
                    <italic toggle="yes">p =</italic> 0.00388) and quadratic (
                    <italic toggle="yes">p =</italic> 0.00681) terms were statistically significant. The fitted regression equation was logit(&#x03c0;) =&#x2212;8.241+0.2281 x&#x2212;0.00281 x
                    <sup>2</sup>, where &#x03c0; is the probability of death by suicide and 
                    <italic toggle="yes">x</italic> is age. Using differential calculus, the function was maximised with respect to age, and it was thereby estimated that the age at which death by suicide risk is highest, is 41. A similar logistic regression model was run where the dependent variable cases were classified as positive for attempted suicide 
                    <italic toggle="yes">or</italic> death by suicide. The linear (
                    <italic toggle="yes">p =</italic>
 0.0299) and quadratic (
                    <italic toggle="yes">p</italic> = 0.0290) age terms were statistically significant in the resulting model, albeit with higher 
                    <italic toggle="yes">p</italic>-values than for the model that considered death by suicide only. The fitted model equation is logit(&#x03c0;) =&#x2212;4.566+0.08383 x&#x2212;0.001109 x
                    <sup>2</sup>. This model predicts that the age at which the risk of attempted suicide or death by suicide is maximized is 38, which is not very different from the result obtained from the model that considered death by suicide only.</p>
                <p>This suggests that the risk of death by suicide among health care consumers increase with age until a peak age of 41 and decreases thereafter. The median ages for death by suicide and attempted suicide were 36 years and 30 years, respectively. 
                    <xref ref-type="fig" rid="f1">
Figure 1</xref> shows the age distribution of health care consumers who had and had not attempted suicide using two overlaid histograms. 
                    <xref ref-type="fig" rid="f2">
Figure 2</xref> similarly shows the age distribution of health care consumers who had and had not died by suicide. The purple area in each plot denotes overlap between the two overlaid histograms. The two figures cohere with the logistic regression findings: there is no visible difference between the red and blue histograms in 
                    <xref ref-type="fig" rid="f1">
Figure 1</xref>; hence no evidence of a difference in age distribution between those who attempted suicide and those who did not. In 
                    <xref ref-type="fig" rid="f2">
Figure 2</xref>, however, the blue histogram&#x2019;s density is concentrated in the middle, suggesting that health care consumers who died by suicide were particularly concentrated in the 30-50 age group.</p>
                <fig fig-type="figure" id="f1" orientation="portrait" position="float">
                    <label>
Figure 1. </label>
                    <caption>
                        <title>Age distribution of health care consumers who did and did not attempt suicide.</title>
                        <p>
                            <xref ref-type="fig" rid="f1">
Figure 1</xref> shows the age distribution of health care consumers who had an had not attempted suicide using two overlaid histograms. From the logistic regression findings, the purple area in each plot denotes overlap between the two overlaid histograms while there is no visible difference between the red and blue histograms, suggesting no visible difference in age distribution between those who had and had not attempted suicide. Age was not a predictor of occurrence for &#x2018;Attempted Suicide&#x2019; (p = 0.3095). From 3 years (2017-2019) of retrospective data, the median age for attempted suicide was 30 years old.</p>
                    </caption>
                    <graphic id="gr1" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/197040/eb36b76d-08e7-4f21-8366-9d23aae41a68_figure1.gif"/>
                </fig>
                <fig fig-type="figure" id="f2" orientation="portrait" position="float">
                    <label>
Figure 2. </label>
                    <caption>
                        <title>Age distribution of health care consumers who did and did not die by suicide.</title>
                        <p>
                            <xref ref-type="fig" rid="f2">
Figure 2</xref> shows the age distribution of health care consumers who did and did not die by suicide using two overlaid histograms. From the logistic regression findings, purple area in each plot denotes overlap between the two overlaid histograms. Unlike 
                            <xref ref-type="fig" rid="f1">
Figure 1</xref>, the blue histogram&#x2019;s density is concentrated in the middle, suggesting that health care consumers who died by suicide were particularly concentrated in the 30-50 age group. Age was not a predictor of occurrence for &#x2018;Death by Suicide&#x2019; (
                            <italic toggle="yes">p = 0.3089</italic>), however using a quadratic age term to check for non-monotonic relationships it was found in the &#x2018;Suicide&#x2019; model, both the linear (
                            <italic toggle="yes">p =</italic> 0.00388) and quadratic (
                            <italic toggle="yes">p =</italic> 0.00681) terms were statistically significant. This suggests that the risk of death by suicide among healthcare consumers increase with age until a peak age of 41 and decreases thereafter. From 3 years (2017-2019) of retrospective data, the median age for suicide was 36 years old.</p>
                    </caption>
                    <graphic id="gr2" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/197040/eb36b76d-08e7-4f21-8366-9d23aae41a68_figure2.gif"/>
                </fig>
                <p>Using the Pearson Chi-square test of independence, it was found that the 
                    <italic toggle="yes">p</italic>-value was 
                    <italic toggle="yes">&lt; 0.05</italic> for the associations between gender and attempted suicide (
                    <italic toggle="yes">p = 0.004484</italic>) and gender and death by suicide (
                    <italic toggle="yes">p = 1.716 &#x00d7; 10
                        <sup>&#x2212;8</sup>
                    </italic>), suggesting males are more likely than females to die by suicide and attempt suicide. A logistic regression model was also fitted, with gender as the independent variable. Gender was again found to be a statistically significant predictor of both attempted suicide (
                    <italic toggle="yes">p</italic>
 = 0.00362) and death by suicide (
                    <italic toggle="yes">p =</italic> 1.78 &#x00d7; 10
                    <sup>&#x2212;7</sup>). The logistic regression model also allowed for computation of expected odds ratios. The odds of males attempting suicide were found to be 2.053 times as high as the odds of females attempting suicide, while the odds of males dying by suicide were found to be 5.049 times as high as those of females (
                    <xref ref-type="bibr" rid="ref54">Tilley et al., 2023</xref>).</p>
                <p>To analyse possible relationships between gender and age and the method of (attempted) suicide, cases of attempted suicide and death by suicide were combined to increase the frequencies. There were then 133 cases of asphyxiation/hanging, 22 cases of overdose or poisoning, and 28 cases of other or unspecified methods. Due to this response variable having three categories, a multinomial logistic regression model (
                    <xref ref-type="table" rid="T3">
Table 3</xref>) was fitted with method of death by suicide/attempted suicide as a response variable and age and gender as independent variables, with an interaction of age and gender as well. No statistically significant coefficient predictors were found in the model at the 5% level. Looking at the method of death by suicide/attempted suicide vs. gender using Fisher&#x2019;s Exact Test (
                    <xref ref-type="table" rid="T4">
Table 4</xref>), there was a statistically significant relationship (
                    <italic toggle="yes">p = 0.0005098</italic>), specifically, it appears that males are more likely to use asphyxiation/hanging, while females are more likely to use poisoning or overdose.</p>
                <table-wrap id="T3" orientation="portrait" position="float">
                    <label>
Table 3. </label>
                    <caption>
                        <title>Multinomial logistic regression to predict Death by Suicide or Attempted Suicide method by age and gender.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <tbody>
                            <tr>
                                <td align="left" colspan="5" rowspan="1" valign="top">
                                    <italic toggle="yes">Coefficients:</italic>
</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Method</bold>
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>(Intercept)</bold>
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Age</bold>
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Male</bold>
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">

                                    <bold>Age * Male</bold>
</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <italic toggle="yes">Other or unspecified</italic>
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-1.278676</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.02476155</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.9989150</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.01170249</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <italic toggle="yes">Asphyxiation/hanging</italic>
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1.704831</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-0.03863174</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.5557824</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.04890228</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="5" rowspan="1" valign="top">
                                    <italic toggle="yes">Std. Errors:</italic>
</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Method</bold>
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>(Intercept)</bold>
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Age</bold>
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Male</bold>
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Age * Male</bold>
</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <italic toggle="yes">Other or unspecified</italic>
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1.2664027</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.02880904</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2.380916</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.06678731</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <italic toggle="yes">Asphyxiation/hanging</italic>
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.9889576</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.02636292</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2.006309</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.05978044</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="5" rowspan="1" valign="top">
                                    <italic toggle="yes">p-values
</italic>
</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Method</bold>
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>(Intercept)</bold>
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Age</bold>
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Male</bold>
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Age * Male</bold>
</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <italic toggle="yes">Other or unspecified</italic>
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.3126430</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.3900612</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.6748137</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.8609066</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <italic toggle="yes">Asphyxiation/hanging</italic>
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0847319</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.1428169</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.7817668</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.4133392</td>
                            </tr>
                        </tbody>
                    </table>
                    <table-wrap-foot>
                        <p>
                            <xref ref-type="table" rid="T3">
Table 3</xref> presents the results from a multinominal logistic regression model used to predict death by suicide or attempted suicide method by age and gender. To analyse possible relationships between gender and age and the method of (attempted) suicide, cases of attempted suicide and death by suicide were combined to increase the frequencies. The multinomial logistic regression model was fitted with method of suicide/attempted suicide as a response variable and age and gender as independent variables, with an interaction of age and gender as well. No statistically significant coefficient predictors were found in the model at the 5% level. There were 133 cases of strangulation, 22 cases of overdose or poisoning and 28 cases of other or unspecified method.</p>
                    </table-wrap-foot>
                </table-wrap>
                <table-wrap id="T4" orientation="portrait" position="float">
                    <label>
Table 4. </label>
                    <caption>
                        <title>Fisher&#x2019;s Exact Test &#x2013; Gender association to type of Death by Suicide.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Gender</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Overdose/poisoning</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Other/Unspecified</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">
Asphyxiation/hanging</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Female</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">59.1%</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">35.7%</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">15.8%</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Male</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">22.7%</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">35.7%</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">48.1%</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Unknown</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">18.2%</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">28.6%</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">36.1%</td>
                            </tr>
                        </tbody>
                    </table>
                    <table-wrap-foot>
                        <p>p-value = 0.0005098; Alternative hypothesis: two.sided. </p>
                        <p>
                            <xref ref-type="table" rid="T4">
Table 4</xref> presents the results of Fisher&#x2019;s Exact Test, used to test for an association between gender and type of death by suicide, for the 3-year (2017-2019) census data. Looking at the method of death by suicide/attempted suicide vs. gender using Fisher's Exact Test, there was a statistically significant relationship (
                            <italic toggle="yes">p = 0.0005098</italic>), specifically, it appears that males are more likely to use strangulation, while females are more likely to use poisoning or overdose from the study site.</p>
                    </table-wrap-foot>
                </table-wrap>
                <p>An ANOVA was also run to check for differences in mean age of victims (dependent variable) across the three methods of death by suicide or attempted suicide (
                    <xref ref-type="table" rid="T5">
Table 5</xref>). Statistically significant differences between groups were identified (
                    <italic toggle="yes">p = 0.0333</italic>). Using Tukey&#x2019;s HSD method for post hoc comparisons (
                    <xref ref-type="table" rid="T6">
Table 6</xref>), it was found that the mean age of asphyxiation/hanging victims is less than the mean age of &#x201c;Other or unspecified&#x201d; victims (
                    <italic toggle="yes">p = 0.0414684</italic>) (
                    <xref ref-type="bibr" rid="ref53">Tilley, 2025</xref>).</p>
                <table-wrap id="T5" orientation="portrait" position="float">
                    <label>
Table 5. </label>
                    <caption>
                        <title>ANOVA &#x2013; Age relationship with method of Attempted Suicide or Death by Suicide.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">
Term</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Degree of Freedom</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Sum of Squared Residuals</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Mean Squared</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">F-value
</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">
p-value
</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Method of Death by Suicide</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1017.113</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">508.5565</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">3.509373</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0333395</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Residuals</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">109</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">15795.601</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">144.9138</td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                        </tbody>
                    </table>
                    <table-wrap-foot>
                        <p>
                            <xref ref-type="table" rid="T5">
Table 5</xref> presents results for an Analysis of Variance (ANOVA) that was run to check for differences in mean age of victims (dependent variable) across the three methods of death by suicide or attempted suicide. Statistically significant differences between groups were identified at 
                            <italic toggle="yes">p = 0.0333</italic> from the census data over the 3-year period (2017-2019).</p>
                    </table-wrap-foot>
                </table-wrap>
                <table-wrap id="T6" orientation="portrait" position="float">
                    <label>
Table 6. </label>
                    <caption>
                        <title>Tukey&#x2019;s HSD Results - Differences in Mean Age by Method of Attempted Suicide or Death by Suicide.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Comparison</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Difference in Means</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Lower Confidence Limit</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Upper Confidence Limit</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Adjusted p-value</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Other or unspecified-overdose or poisoning</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2.750000</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-6.543301</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">12.0433011</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.76215151</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Asphyxiation/hanging-overdose or poisoning</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-4.689189</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-12.206652</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2.8282732</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.30343063</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Asphyxiation/hanging-other or unspecified</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-7.439189</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-14.647982</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-0.2303966</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.04146837</td>
                            </tr>
                        </tbody>
                    </table>
                    <table-wrap-foot>
                        <p>
                            <xref ref-type="table" rid="T6">
Table 6</xref> presents the results for Tukey&#x2019;s Honest Significant Difference (HSD) test. This method is based on a studentized rage statistic and is used in connection with analysis of variance (ANOVA) as a post hoc method to identify pairwise significant differences. Using Tukey&#x2019;s HSD method for post hoc comparisons, it was found that the mean age of strangulation victims is less than the mean age of &#x201c;Other or unspecified&#x201d; victims (
                            <italic toggle="yes">p = 0.0414684</italic>) from the census data over the 3-year period (2017-2019).</p>
                    </table-wrap-foot>
                </table-wrap>
            </sec>
        </sec>
        <sec id="sec16" sec-type="discussion">
            <title>Discussion</title>
            <p>There was a range of death by suicide and suicidality typologies in the Garden Route District over the 3-year study period, presenting in 14% (
                <italic toggle="yes">n</italic>
 = 412) of IMRs sampled (representing health care consumer engagement). Death by suicide took place on average 2.8 (
                <italic toggle="yes">n </italic>= 102) times a month, and attempted suicide 2.3 (
                <italic toggle="yes">n </italic>= 83) times a month, and roughly 6.3 (
                <italic toggle="yes">n</italic>
 = 227) health care consumers presented to the WCEMS with suicidal ideation monthly. Notably 63% (
                <italic toggle="yes">n</italic>
 = 1890) of IMRs (health care consumers) presented with mental illness sequela, often related to suicide and suicidality victims&#x2019; medical history (
                <xref ref-type="bibr" rid="ref21">Klonsky et al., 2016</xref>; 
                <xref ref-type="bibr" rid="ref23">Ku&#x0142;ak-Bejda et al., 2021</xref>). Significantly, in the same sample, males were five and two times more likely to die by suicide and attempt suicide than females, respectively (
                <xref ref-type="bibr" rid="ref54">Tilley et al., 2023</xref>). Males appeared more likely to use asphyxiation/hanging, while females used overdose or poisoning as a means of death by suicide in the study site (
                <xref ref-type="bibr" rid="ref54">Tilley et al., 2023</xref>). This dataset identified the risk of death by suicide, in a LMIC, to increase with age, until a peak age of 41 and decreases thereafter, making death by suicide risk the highest at 41 years of age. The median ages for death by suicide and attempted suicide were 36 years and 30 years, respectively. Notably in LMICs, suicide is a major public health issue, with 77% to 88% of global suicides occurring in these settings. While suicide rates increase with age in many regions, LMICs show a significant, distinct peak in suicide mortality among young adults, particularly those aged 15&#x2013;29 years and 30&#x2013;49 years (
                <xref ref-type="bibr" rid="ref64">Vijayakumar et al., 2016</xref>).</p>
            <p>The data analysis provided similar inferences already denoted in articles on suicide globally, with asphyxiation/hanging being the most common method, and men being the most likely to die by suicide (
                <xref ref-type="bibr" rid="ref21">Klonsky et al., 2016</xref>; 
                <xref ref-type="bibr" rid="ref22">Kootbodien et al., 2020</xref>; 
                <xref ref-type="bibr" rid="ref39">Rahman et al., 2017</xref>; 
                <xref ref-type="bibr" rid="ref42">Ritchie et al., 2015</xref>). However, the presence of suicidal ideation, attempted suicides, cutting self-harm and overdose/DSP in the dataset is what was illuminating. Understandably, antecedents for suicidality (
                <xref ref-type="bibr" rid="ref21">Klonsky et al., 2016</xref>; 
                <xref ref-type="bibr" rid="ref24">Lim et al., 2019</xref>), individuals who inflict non-suicidal self-injury (disorder) are at risk of suicide attempts (
                <xref ref-type="bibr" rid="ref6">Brager-Larsen et al., 2024</xref>), while suicidal ideation and progression into suicide attempts are two phenomena that produce predictors towards death by suicide (
                <xref ref-type="bibr" rid="ref59">World Health Organization, 2014</xref>). Using the ideation-to-action framework, literature suggests deliberate self-harm and depression to be early and accurate indicators for suicidal ideation and suicidality (
                <xref ref-type="bibr" rid="ref21">Klonsky et al., 2016</xref>). The mental illness sequela from the dataset could suggest that, through better medical surveillance, more effort could be put into early suicide detection, knowing that PTSD, bipolar disorder, depression, substance abuse and suicidal ideation are associated with suicide deaths (
                <xref ref-type="bibr" rid="ref21">Klonsky et al., 2016</xref>). Prehospital emergency medical care provides health action to health conditions through emergency medicine in a time sensitive approach with universality and responsivity (
                <xref ref-type="bibr" rid="ref9">Christopher et al., 2014</xref>; 
                <xref ref-type="bibr" rid="ref32">Naidoo, 2017</xref>; 
                <xref ref-type="bibr" rid="ref54">Tilley et al., 2023</xref>) and can recognise the patterns and needs of mental healthcare consumers from an early stage to interrupt suicidality and limit access to methods of harm (
                <xref ref-type="bibr" rid="ref14">Florentine &amp; Crane, 2010</xref>).</p>
            <p>This dataset does not explain the perceptions prehospital EC providers have towards health care consumers who have suicidal ideation, suicidality and have attempted suicide. In various articles prehospital EC providers have explained to feel misconstrued on the concept of mental illness, self-harm and suicidality, often feeling lost and depleted by lack of legislation and policy, treatment protocols, training, guidance and personal negative conflict on own perceptions of attending mental health emergencies rather than trauma/medical emergencies (
                <xref ref-type="bibr" rid="ref13">Evans et al., 2018</xref>; 
                <xref ref-type="bibr" rid="ref34">O&#x2019;Sullivan, 2014</xref>; 
                <xref ref-type="bibr" rid="ref41 ref40">Rees et al., 2015, 2018</xref>; 
                <xref ref-type="bibr" rid="ref50">Stander et al., 2021</xref>). In a study done in the same province in SA, it was found that 80% of the prehospital EC providers in the study had no prior training to manage suicidal health care consumers, seldom using formal suicide evaluation and capacity check tools, while implying negative feelings and connotations towards attempted suicide victims (
                <xref ref-type="bibr" rid="ref13">Evans et al., 2018</xref>). Inevitably, this lack of compassion, training and knowledge provides a precarious situation for prehospital EC providers, as this could prevent early mental health surveillance and suicidality interruption. A lack of praxis and management of suicidality and death by suicide caseload could put the EC provider helpless, creating an emotional backlash with direct or vicarious traumatisation to the EC provider. Notably, prehospital EC providers have disclosed battling with lasting visions from death by suicide scenes and battling with anxiety, PTSD and depression (
                <xref ref-type="bibr" rid="ref35">Padmanabhanunni &amp; Pretorius, 2025</xref>; 
                <xref ref-type="bibr" rid="ref43">Rothes et al., 2020</xref>).</p>
            <p>WCEMS prehospital EC providers locate in the suicide and suicidality burden and need to consider analytical clinical decision making (
                <xref ref-type="bibr" rid="ref12">Emond et al., 2024</xref>) in managing and treating mental healthcare consumers while considering the societal, cultural, religious and socioeconomic risk factors synonymous with suicide in SA (
                <xref ref-type="bibr" rid="ref22">Kootbodien et al., 2020</xref>). SA is precariously placed in the mental health milieu, with deinstitutionalisation and no appropriate policy and compensatory community mental health care services created (
                <xref ref-type="bibr" rid="ref30">Motsoaledi &amp; Matsoso, 2013</xref>; 
                <xref ref-type="bibr" rid="ref58">World Health Organization, 2003</xref>). Atrocities from apartheid, poverty and inequality create exponential societal risk levels for suicidality and suicide, placing the prehospital EC provider and EMS at the forefront of mental health and suicidality emergencies. Located in the forefront of this caseload, prehospital EC providers need to have capacity to manage, treat and transport these health care consumers, have potential to interrupt suicidality by limiting access to harmful methods (
                <xref ref-type="bibr" rid="ref14">Florentine &amp; Crane, 2010</xref>), contribute to social capital through latent capacity (
                <xref ref-type="bibr" rid="ref54">Tilley et al., 2023</xref>) while minding risk of direct and vicarious self-traumatization (
                <xref ref-type="bibr" rid="ref45">Sandford et al., 2021</xref>).</p>
            <p>This socioeconomic landscape renders the concept of further research into Trauma Informed Care (TIC) as an interlude to disrupt negative postulation to suicidality, whereby understanding that childhood traumatic experiences can show signs of future mental health challenges, as most (mental) health is affected by past trauma (
                <xref ref-type="bibr" rid="ref29">Melillo et al., 2025</xref>; 
                <xref ref-type="bibr" rid="ref44">SAMHSA, 2014</xref>). Understanding and researching the benefits of TIC could be purposeful in an approach to management and training for healthcare consumers and EC providers respectively. The illumination of TIC and a syndemic approach to suicide could be associated with a dignified response to managing a marginalized group and the risk of vicarious traumatization of the EC provider (
                <xref ref-type="bibr" rid="ref45">Sandford et al., 2021</xref>). Subsequently, a syndemic approach to suicide (
                <xref ref-type="bibr" rid="ref8">Caulkins, 2022</xref>) in Southern Africa could be associated with interrupting suicidality, protecting people living (and dying) with such risk. Suicidality and suicide phenomenon is a complexity of challenges and the syndemic approach shows intersectionality to these challenges. The syndemic approach looks at suicide as a combination of challenges like culture, poverty, socioeconomic circumstances, mental illness, violence, trauma, chronic pain and stigma which amplify each other (
                <xref ref-type="bibr" rid="ref8">Caulkins, 2022</xref>). By manifesting research into the syndemic approach, the EMS could reflect this approach through training EC providers to identify suicidality as a product of behavioral, clinical and social challenges whereby TIC, medical treatment and referral pathways are tailored to mitigate risk of harm.</p>
        </sec>
        <sec id="sec17" sec-type="conclusion">
            <title>Conclusion</title>
            <p>
                <xref ref-type="bibr" rid="ref54">Tilley et al. (2023)</xref> described the Deliberate Self-Harm burden for the prehospital EMS; however, the novelty in this paper lies in the typological disaggregation of suicidality and death by suicide within EMS records. The authenticity of this research elucidates the suicidality burden faced by the South African prehospital EMS. Death by suicide and suicidality typology in the EMS have not been previously assessed in SA, illuminating a research and practice problem space. This study describes the prehospital suicide and suicidality burden for the WCEMS. Prehospital EC providers need to retain the praxis, training, emotion, policies and legislation to comprehensively manage, treat and transport healthcare consumers with suicidality (
                <xref ref-type="bibr" rid="ref48">Simpson et al., 2025</xref>) and that this proven challenge could require lateral deliberation (
                <xref ref-type="bibr" rid="ref12">Emond et al., 2024</xref>). This documented death by suicide and suicidality typology presents a novel and fundamental understanding of the prehospital suicidality problem space definition. This study quantifies the burden for the EMS; however, it provides no solution to training, management, treatment, or EC provider perception towards death by suicide and suicidality. Further study is required on EC provider stigmatisation towards death by suicide and suicidality, while auditing the need to assess policy, praxis, medical surveillance, EC provider clinical competency capacity and suicidality victim perspectives, as healthcare consumer level interventions on strategic suicide prevention have aided in the reduction of suicide attempts (
                <xref ref-type="bibr" rid="ref62">Zarska et al., 2023</xref>).</p>
            <sec id="sec18">
                <title>Limitations of the study</title>
                <p>Emergency call takers are not trained mental health care professionals and do not make mental health diagnoses, while the vernacular of the healthcare consumers provide a challenge in reporting. The inherent risk of retrospective medical records includes misclassification bias, e.g., where a case was incorrectly categorised as death by suicide when it was death by some other cause, or vice versa. Retrospective data limitations also apply. Risk of type one error is mitigated by the significance level and large sample size. This dataset does not elucidate perceptions of prehospital EC providers towards suicidality and relies on call taker and dispatcher reporting. Notably there is a lack of post event outcome verification, such as post-mortem data.</p>
            </sec>
        </sec>
        <sec id="sec19">
            <title>Ethical considerations</title>
            <p>Ethics was granted for this study through the Research Ethics Committee of the Cape Peninsula University of Technology 
                <italic toggle="yes">(CPUT/HW-REC 2019/H17).</italic> Permission for access to the Western Cape National Health Research Database was obtained from the Western Cape Government 
                <italic toggle="yes">(WC_201911_033).</italic>
            </p>
        </sec>
    </body>
    <back>
        <sec id="sec23" sec-type="data-availability">
            <title>Data availability</title>
            <p>Figshare: Access to health care for health care consumers with mental health needs: an Emergency Medical Service perspective. 
                <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.6084/m9.figshare.30392569">https://doi.org/10.6084/m9.figshare.30392569</ext-link>. The project contains raw retrospective data in an Excel spreadsheet with analysed data in graphs and tables using R statistical software, Binary and multinomial logistic regression, Pearson&#x2019;s Chi-squared test of independence, Fisher&#x2019;s Exact Test, Analysis of Variance (ANOVA), and Tukey&#x2019;s Honest Significant Difference (HSD). A dissertation with full analysis is also provided. Data are available under the terms of the 
                <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International licence</ext-link> (CC-BY 4.0) (
                <xref ref-type="bibr" rid="ref53">Tilley, 2025</xref>).</p>
        </sec>
        <ack>
            <title>Acknowledgements</title>
            <p>&#x2018;Suicide is everybody&#x2019;s business&#x2019; (
                <xref ref-type="bibr" rid="ref47">Shneidman, 1985</xref>, p. 238). We acknowledge the 102 health care consumers represented in this study who died by suicide as we try to advance improved treatment pathways and prevent death by suicide.</p>
        </ack>
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                <mixed-citation publication-type="other">
                    <collab>World Bank Group</collab>:
                    <chapter-title>Poverty &amp; Equity Brief - South Africa April 2020.</chapter-title>
                    <source>

                        <italic toggle="yes">Poverty &amp; Equity Brief.</italic>
</source>
                    <year>2020</year>. (Issue April).
                    <ext-link ext-link-type="uri" xlink:href="https://databankfiles.worldbank.org/data/download/poverty/33EF03BB-9722-4AE2-ABC7-AA2972D68AFE/Global_POVEQ_ZAF.pdf">Reference Source</ext-link>
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                <mixed-citation publication-type="other">
                    <collab>World Health Organization</collab>:
                    <chapter-title>Mental Health Policy and Service Guidance Package: The Mental Health Context.</chapter-title>
                    <source>

                        <italic toggle="yes">Mental Health Policy and Service Guidance Package.</italic>
</source>
                    <year>2003</year>.
                    <ext-link ext-link-type="uri" xlink:href="http://www.who.int/mental_health/resources/en/context.PDF">Reference Source</ext-link>
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                    <collab>World Health Organization</collab>:
                    <source>

                        <italic toggle="yes">Preventing suicide-A global imperative.</italic>
</source>
                    <publisher-name>WHO Press</publisher-name>;<year>2014</year>.
                    <ext-link ext-link-type="uri" xlink:href="https://apps.who.int/iris/bitstream/handle/10665/131056/9789241564779_eng.pdf">Reference Source</ext-link>
                </mixed-citation>
            </ref>
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                <mixed-citation publication-type="journal">
                    <collab>World Health Organization</collab>:
                    <article-title>World health statistics 2024: monitoring health for the SDGs.</article-title>
                    <source>

                        <italic toggle="yes">Sustainable Development Goals.</italic>
</source>
                    <year>2024</year>.
                    <ext-link ext-link-type="uri" xlink:href="https://iris.who.int/bitstream/handle/10665/376869/9789240094703-eng.pdf?sequence=1">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref61">
                <mixed-citation publication-type="other">
                    <collab>World Health Organization</collab>:
                    <article-title>Suicide worldwide in 2021: global health estimates.</article-title>
                    <year>2025</year>.
                    <ext-link ext-link-type="uri" xlink:href="https://iris.who.int/bitstream/handle/10665/381495/9789240110069-eng.pdf?sequence=1">Reference Source</ext-link>
                </mixed-citation>
            </ref>
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                    <person-group person-group-type="author">

                        <name name-style="western">
                            <surname>Zarska</surname>
                            <given-names>A</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Barnicot</surname>
                            <given-names>K</given-names>
                        </name>

                        <name name-style="western">
                            <surname>Lavelle</surname>
                            <given-names>M</given-names>
                        </name>

                        <etal/>
</person-group>:
                    <article-title>A Systematic Review of Training Interventions for Emergency Department Providers and Psychosocial Interventions delivered by Emergency Department Providers for Patients who self-harm.</article-title>
                    <source>

                        <italic toggle="yes">Arch. Suicide Res.</italic>
</source>
                    <year>2023</year>;<volume>27</volume>(<issue>3</issue>):<fpage>829</fpage>&#x2013;<lpage>850</lpage>.
                    <pub-id pub-id-type="pmid">35583506</pub-id>
                    <pub-id pub-id-type="doi">10.1080/13811118.2022.2071660</pub-id>
                </mixed-citation>
            </ref>
        </ref-list>
    </back>
    <sub-article article-type="reviewer-report" id="report464405">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.197040.r464405</article-id>
            <title-group>
                <article-title>Reviewer response for version 3</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Craig</surname>
                        <given-names>Wesley</given-names>
                    </name>
                    <xref ref-type="aff" rid="r464405a1">1</xref>
                    <role>Referee</role>
                </contrib>
                <aff id="r464405a1">
                    <label>1</label>University of Cape Town Division of Emergency Medicine (Ringgold ID: 536985), Cape Town, Western Cape, South Africa</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>6</day>
                <month>3</month>
                <year>2026</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2026 Craig W</copyright-statement>
                <copyright-year>2026</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport464405" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.171712.3"/>
            <custom-meta-group>
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        <body>
            <p>Well done to the authors on a well presented manuscript. I have no further comments.</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Yes</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Yes</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Partly</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Yes</p>
            <p>Reviewer Expertise:</p>
            <p>NA</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.</p>
        </body>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report464406">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.197040.r464406</article-id>
            <title-group>
                <article-title>Reviewer response for version 3</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Mottershead</surname>
                        <given-names>Richard</given-names>
                    </name>
                    <xref ref-type="aff" rid="r464406a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0003-0048-0553</uri>
                </contrib>
                <aff id="r464406a1">
                    <label>1</label>College of Nursing, University of Baghdad, Baghdad, Iraq</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>5</day>
                <month>3</month>
                <year>2026</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2026 Mottershead R</copyright-statement>
                <copyright-year>2026</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport464406" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.171712.3"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>Dear Authors,</p>
            <p> </p>
            <p> Thank you for your careful and considered responses to the points raised during the review process. I appreciate the clarity and diligence with which you have addressed each comment and strengthened the manuscript accordingly.</p>
            <p> </p>
            <p> The revised paper, 
                <italic>Typologies of suicidality and suicide presenting to a prehospital South African Emergency Medical Service: a retrospective cross-sectional analysis</italic>, makes a notable contribution to the field. By examining patterns of suicidality within the prehospital EMS context, the study adds valuable knowledge to an under-researched area and increases awareness of the complexity and burden of suicide-related presentations in emergency care settings.</p>
            <p> </p>
            <p> The work has clear relevance for clinical practice, service planning, and future research, particularly within resource-constrained and high-demand healthcare environments. It provides meaningful insights that can inform training, policy development, and targeted prevention strategies.</p>
            <p> </p>
            <p> Thank you for your thoughtful revisions and for contributing important evidence to this critical area of public health and emergency care.</p>
            <p> </p>
            <p> Kindest regards,</p>
            <p> Dr. Richard Mottershead</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Partly</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Yes</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Partly</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Partly</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Reviewer Expertise:</p>
            <p>My area of research is in mental health, societial challenges, applied research</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.</p>
        </body>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report458179">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.194504.r458179</article-id>
            <title-group>
                <article-title>Reviewer response for version 2</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Craig</surname>
                        <given-names>Wesley</given-names>
                    </name>
                    <xref ref-type="aff" rid="r458179a1">1</xref>
                    <role>Referee</role>
                </contrib>
                <aff id="r458179a1">
                    <label>1</label>University of Cape Town Division of Emergency Medicine (Ringgold ID: 536985), Cape Town, Western Cape, South Africa</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>19</day>
                <month>2</month>
                <year>2026</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2026 Craig W</copyright-statement>
                <copyright-year>2026</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport458179" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.171712.2"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>Thanks so much for the opportunity to review. The paper certainly addresses an important and under-researched area in South African out-of-hospital emergency care and its intersection with mental health care provision.</p>
            <p> This study examined the burden and typology of suicidality encountered by EMS in the Garden Route District of the Western Cape, South Africa. It used a retrospective cross-sectional analysis of EMS records from 2017-2019. From 413,712 EMS records, the authors identified 2,976 mental-health-related incidents, of which 412 involved suicidality, including suicidal ideation, attempted suicide, and death by suicide. The study found gender differences in suicide method and outcomes. Men were significantly more likely to die by suicide than women, and strangulation was the most common method among men, while poisoning or medication overdose was more common among women. The authors conclude that suicidality represents a meaningful but under-recognised component of the EMS caseload in South Africa. Improved training, policy guidance, mental-health surveillance, and research into EMS provider experiences and stigma was recommended. I believe the study is conceptually strong and publishable with minor-to-moderate revision. 
                <list list-type="bullet">
                    <list-item>
                        <p>The research aim could be stated explicitly, aside from the abstract, it seems to be narratively embedded in the background. This also goes for the objectives; they don&#x2019;t seem to be listed clearly anywhere.</p>
                    </list-item>
                    <list-item>
                        <p>It would be helpful to the readership to state earlier that the case descriptions are based on EMS call-taker and call-categories not postmortem findings. This is especially important when determining intent in terms of &#x201c;Death by suicide&#x201d; vs accidental death and homicide. This is brought up in limitations, but should come earlier in methods and briefly in discussion (in general the misclassification bias/call-taker judgment etc).</p>
                    </list-item>
                    <list-item>
                        <p>While the analysis and results appear robust, the level of statistical explanation is more detailed than necessary for most journals and at times reads like a dissertation. This can be quickly addressed by summarising the rationale for each test then focussing on interpretation rather than statistical pedagogy.</p>
                    </list-item>
                    <list-item>
                        <p>Please refrain from citing papers which are not directly relevant to the statements (e.g. &#x201c;The null hypothesis (H0) states &#x2018;there is no association between two variables while the alternative hypothesis (Ha) states, there is an association between two variables (Bolboac&#x0103; et al., 2011, p. 530; Tilley, 2021; Tilley et al., 2023).&#x201d; The latter two references are not papers informing methods/analytic approaches. There are quite a few of these in the manuscript, please look out for these throughout.</p>
                    </list-item>
                    <list-item>
                        <p>I would suggest that references to previous publications using the same dataset should be moved from the Results section to the Introduction or Discussion, and the novelty of the present analysis should be stated more clearly.</p>
                    </list-item>
                    <list-item>
                        <p>A significant amount of time is spent on &#x201c;age&#x201d; (41 years being peak risk) as a variable yet there is no mention of it in the discussion. It would be useful to link this to other literature as it remains without context here.</p>
                    </list-item>
                    <list-item>
                        <p>The discussion is strong and statements suggesting that EMS adopt TIC approaches is almost certainly valid, however it does move beyond the descriptive epidemiological nature of the manuscript. These can rather be framed as implications for users, or just areas for future research.</p>
                    </list-item>
                    <list-item>
                        <p>Syndemic is a novel point of discussion and has value here however it seems awkwardly placed in the introduction, with nothing in the discussion, then brought back into the conclusion. &#x201c;&#x2026;however, the novelty in this paper provides and removes the DSH scope and focuses on prehospital suicidality typology while suggesting a syndemic approach to suicide in the African setting.&#x201c; I don&#x2019;t believe it does this in its current form. Some more practical application could be valuable here, what would it look like if EMS training reflected this approach? The term is also inconsistently written in quotation marks.</p>
                    </list-item>
                    <list-item>
                        <p>Trauma-informed care is also brought in at the latter end of the discussion with more explanation provided in the conclusion, this should be moved to the discussion section as no new information should be presented in the conclusion.</p>
                    </list-item>
                    <list-item>
                        <p>Consent: The manuscript mentions &#x201c;Western Cape Government National Department of Health Ethics Council (WC_201911_033)&#x201d; I don&#x2019;t believe this is the name of a single formal ethics committee. It appears to be a mislabelled or conflated reference to two different structures. That said, the ref number looks like a National Health Research Database (NHRD) number for a Western Cape Department of Health and Wellness Research site.</p>
                    </list-item>
                    <list-item>
                        <p>More minor things 
                            <list list-type="bullet">
                                <list-item>
                                    <p>Western Cape Department of Health and Wellness &#x2013; I believe they&#x2019;ve changed from &#x2018;Government&#x2019; to &#x2018;Department&#x2019;.</p>
                                </list-item>
                                <list-item>
                                    <p>&#x201c;healthcare&#x201d; vs &#x201c;health care&#x201d;</p>
                                </list-item>
                                <list-item>
                                    <p>Inconsistent capitalisation of &#x201c;Death by suicide&#x201d;</p>
                                </list-item>
                                <list-item>
                                    <p>Limitations section: &#x201c;don&#x2019;t&#x201d; &#x2013; avoid the use of contractions, try to write in full.</p>
                                </list-item>
                                <list-item>
                                    <p>There are quite a few grammar and spacing gremlins throughout, another proofread will be adequate to pick up on these. In particular the use of inappropriate capitalisation and the inconsistent use of abbreviations.</p>
                                </list-item>
                            </list> </p>
                    </list-item>
                </list>
            </p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Yes</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Yes</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Partly</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Yes</p>
            <p>Reviewer Expertise:</p>
            <p>NA</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
        <sub-article article-type="response" id="comment15511-458179">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Tilley</surname>
                            <given-names>Daniel</given-names>
                        </name>
                        <aff>Emergency Medical Science, Cape Peninsula University of Technology - Bellville Campus, Bellville, Western Cape, South Africa</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>no competing interests</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>22</day>
                    <month>2</month>
                    <year>2026</year>
                </pub-date>
            </front-stub>
            <body>
                <p>Please see comments in Italics. We would like to thank the reviewer for the suggestions and advice in making this article more academically sound for international audiences and the journal as a whole. Thank you 
                    <list list-type="bullet">
                        <list-item>
                            <p>The research aim could be stated explicitly, aside from the abstract, it seems to be narratively embedded in the background. This also goes for the objectives; they don&#x2019;t seem to be listed clearly anywhere.</p>
                        </list-item>
                    </list> 
                    <italic>This has been done accordingly</italic> 
                    <list list-type="bullet">
                        <list-item>
                            <p>It would be helpful to the readership to state earlier that the case descriptions are based on EMS call-taker and call-categories not postmortem findings. This is especially important when determining intent in terms of &#x201c;Death by suicide&#x201d; vs accidental death and homicide. This is brought up in limitations, but should come earlier in methods and briefly in discussion (in general the misclassification bias/call-taker judgment etc).</p>
                        </list-item>
                    </list> 
                    <italic>This has been done accordingly and added earlier in materials and methods</italic> 
                    <list list-type="bullet">
                        <list-item>
                            <p>Please refrain from citing papers which are not directly relevant to the statements (e.g. &#x201c;The null hypothesis (H0) states &#x2018;there is no association between two variables while the alternative hypothesis (Ha) states, there is an association between two variables (Bolboac&#x0103; et al., 2011, p. 530; Tilley, 2021; Tilley et al., 2023).&#x201d; The latter two references are not papers informing methods/analytic approaches. There are quite a few of these in the manuscript, please look out for these throughout.</p>
                        </list-item>
                    </list> 
                    <italic>this has been fixed and changed</italic> 
                    <list list-type="bullet">
                        <list-item>
                            <p>I would suggest that references to previous publications using the same dataset should be moved from the Results section to the Introduction or Discussion, and the novelty of the present analysis should be stated more clearly.</p>
                        </list-item>
                    </list> 
                    <italic>This has been done in the discussion</italic> 
                    <list list-type="bullet">
                        <list-item>
                            <p>A significant amount of time is spent on &#x201c;age&#x201d; (41 years being peak risk) as a variable yet there is no mention of it in the discussion. It would be useful to link this to other literature as it remains without context here.</p>
                        </list-item>
                    </list> 
                    <italic>This has been added and discussed in discussion, thank you.</italic> 
                    <list list-type="bullet">
                        <list-item>
                            <p>The discussion is strong and statements suggesting that EMS adopt TIC approaches is almost certainly valid, however it does move beyond the descriptive epidemiological nature of the manuscript. These can rather be framed as implications for users, or just areas for future research.</p>
                        </list-item>
                    </list> 
                    <italic>This has been done accordingly to this suggestion</italic> 
                    <list list-type="bullet">
                        <list-item>
                            <p>Syndemic is a novel point of discussion and has value here however it seems awkwardly placed in the introduction, with nothing in the discussion, then brought back into the conclusion. &#x201c;&#x2026;however, the novelty in this paper provides and removes the DSH scope and focuses on prehospital suicidality typology while suggesting a syndemic approach to suicide in the African setting.&#x201c; I don&#x2019;t believe it does this in its current form. Some more practical application could be valuable here, what would it look like if EMS training reflected this approach? The term is also inconsistently written in quotation marks.</p>
                        </list-item>
                    </list> 
                    <italic>This has been defined better and fixed accordingly</italic> 
                    <list list-type="bullet">
                        <list-item>
                            <p>Trauma-informed care is also brought in at the latter end of the discussion with more explanation provided in the conclusion, this should be moved to the discussion section as no new information should be presented in the conclusion.</p>
                        </list-item>
                    </list> 
                    <italic>This has been changed accordingly and removed from the conclusion</italic> 
                    <list list-type="bullet">
                        <list-item>
                            <p>Consent: The manuscript mentions &#x201c;Western Cape Government National Department of Health Ethics Council (WC_201911_033)&#x201d; I don&#x2019;t believe this is the name of a single formal ethics committee. It appears to be a mislabelled or conflated reference to two different structures. That said, the ref number looks like a National Health Research Database (NHRD) number for a Western Cape Department of Health and Wellness Research site.</p>
                        </list-item>
                    </list> 
                    <italic>This has been changed as advised. Thank you for this advice</italic> 
                    <list list-type="bullet">
                        <list-item>
                            <p>More minor things 
                                <list list-type="bullet">
                                    <list-item>
                                        <p>Western Cape Department of Health and Wellness &#x2013; I believe they&#x2019;ve changed from &#x2018;Government&#x2019; to &#x2018;Department&#x2019;.</p>
                                    </list-item>
                                    <list-item>
                                        <p>&#x201c;healthcare&#x201d; vs &#x201c;health care&#x201d;</p>
                                    </list-item>
                                    <list-item>
                                        <p>Inconsistent capitalisation of &#x201c;Death by suicide&#x201d;</p>
                                    </list-item>
                                    <list-item>
                                        <p>Limitations section: &#x201c;don&#x2019;t&#x201d; &#x2013; avoid the use of contractions, try to write in full.</p>
                                    </list-item>
                                    <list-item>
                                        <p>There are quite a few grammar and spacing gremlins throughout, another proofread will be adequate to pick up on these. In particular the use of inappropriate capitalisation and the inconsistent use of abbreviations.</p>
                                    </list-item>
                                </list> </p>
                        </list-item>
                    </list> 
                    <italic>Thank you for this advice. this has all been attended to and corrected as suggested.</italic>
                </p>
            </body>
        </sub-article>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report457459">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.194504.r457459</article-id>
            <title-group>
                <article-title>Reviewer response for version 2</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Mottershead</surname>
                        <given-names>Richard</given-names>
                    </name>
                    <xref ref-type="aff" rid="r457459a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0003-0048-0553</uri>
                </contrib>
                <aff id="r457459a1">
                    <label>1</label>College of Nursing, University of Baghdad, Baghdad, Iraq</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>17</day>
                <month>2</month>
                <year>2026</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2026 Mottershead R</copyright-statement>
                <copyright-year>2026</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport457459" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.171712.2"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>I would like to thank the authors for this opportunity to peer review their article.&#x00a0;&#x00a0;</p>
            <p> </p>
            <p> 
                <bold>Summary&#x00a0;</bold>
            </p>
            <p> This study presents a retrospective cross-sectional analysis of suicidality and suicide cases recorded in the Western Cape Government Emergency Medical Services (WCGEMS) Incident Management Records over a three-year period (2017&#x2013;2019) in the Garden Route District of South Africa.</p>
            <p> From 413,712 total EMS records, 2,976 mental health-related cases were identified, of which 412 (14%) involved suicidal ideation, attempted suicide, or death by suicide. The study provides typological analysis of suicide methods, gender associations, and age distributions using logistic regression, multinomial regression, ANOVA, and Fisher&#x2019;s Exact Test. The findings indicate&#x00a0;</p>
            <p> </p>
            <p> -&#x00a0;An average of 2.8 deaths by suicide and 2.3 attempted suicides per month.</p>
            <p> </p>
            <p> -&#x00a0;Males were approximately 5 times more likely to die by suicide than females.</p>
            <p> </p>
            <p> -&#x00a0;Strangulation was the most common method among males; poisoning/overdose predominated among females.</p>
            <p> </p>
            <p> -&#x00a0;Risk of death by suicide appeared to peak at approximately age 41 (quadratic model).</p>
            <p> </p>
            <p> The study aims to quantify and typologise suicidality within the prehospital EMS context and suggests a syndemic framework for understanding suicide within South Africa&#x2019;s socio-economic landscape.</p>
            <p> The topic is highly relevant, particularly in low- and middle-income country contexts where prehospital suicide research is limited. The dataset is substantial, and the statistical analyses are appropriately selected for the research aims.</p>
            <p> </p>
            <p> 
                <bold>Overall Assessment</bold>
            </p>
            <p> This manuscript makes an important contribution by quantifying the prehospital suicidality burden within a rural South African EMS context. The dataset is large, the statistical methods are generally appropriate, and the findings are clearly reported.</p>
            <p> However, my suggestions would be that the authors review these several areas which would (I believe) benefit from clarification and strengthening before full approval. These relate primarily to: 
                <list list-type="bullet">
                    <list-item>
                        <p>Conceptual framing</p>
                    </list-item>
                    <list-item>
                        <p>Operational definitions</p>
                    </list-item>
                    <list-item>
                        <p>Interpretation of statistical findings</p>
                    </list-item>
                    <list-item>
                        <p>Overextension of conclusions</p>
                    </list-item>
                    <list-item>
                        <p>Clarity around &#x201c;novelty&#x201d; claims</p>
                    </list-item>
                </list> These are refinements rather than major corrections but would enhance the hard work and efforts of the research team.&#x00a0;</p>
            <p> </p>
            <p> 
                <bold>Recommendations</bold>
            </p>
            <p> 
                <bold>1. Clarify Operational Definitions and Case Classification</bold>
            </p>
            <p> The manuscript relies on EMS categorisation (e.g., &#x201c;Self-Harm-other,&#x201d; &#x201c;Self-Harm-poisoning,&#x201d; &#x201c;Psychiatric/Behavioural Problems&#x201d;), which are not clinical diagnoses.</p>
            <p> To strengthen methodological clarity, the authors should:</p>
            <p> </p>
            <p> Provide clearer operational definitions of: 
                <list list-type="bullet">
                    <list-item>
                        <p>Suicidal ideation</p>
                    </list-item>
                    <list-item>
                        <p>Attempted suicide</p>
                    </list-item>
                    <list-item>
                        <p>Death by suicide</p>
                    </list-item>
                    <list-item>
                        <p>Explain how misclassification bias may influence estimates.</p>
                    </list-item>
                    <list-item>
                        <p>Clarify how &#x201c;parasuicidal&#x201d; behaviour was differentiated from attempted suicide.</p>
                    </list-item>
                </list> I might suggest that call-takers are not mental health professionals, this is a critical limitation and should be foregrounded more clearly in the methods and limitations sections. Perhaps the call-takers had enhanced training which was not highlighted within the article?&#x00a0;</p>
            <p> </p>
            <p> 
                <bold>2. Strengthen Justification of the &#x201c;Syndemic&#x201d; Framing</bold>
            </p>
            <p> The syndemic concept is introduced as a major theoretical contribution; however, it is not analytically tested within the dataset.</p>
            <p> To strengthen conceptual coherence, the authors should: 
                <list list-type="bullet">
                    <list-item>
                        <p>Clarify whether &#x201c;syndemic&#x201d; is used as:</p>
                    </list-item>
                    <list-item>
                        <p>A theoretical lens,</p>
                    </list-item>
                    <list-item>
                        <p>A hypothesis-generating concept,</p>
                    </list-item>
                    <list-item>
                        <p>Or a demonstrated empirical finding.</p>
                    </list-item>
                    <list-item>
                        <p>Avoid implying that syndemic relationships were statistically examined unless explicitly tested.</p>
                    </list-item>
                    <list-item>
                        <p>Consider moderating the claim of novelty unless the framework is analytically integrated into results.</p>
                    </list-item>
                </list> Currently, the syndemic argument is persuasive but somewhat aspirational rather than empirically grounded in the presented analysis.</p>
            <p> </p>
            <p> 
                <bold>3. Moderate Claims of Novelty</bold>
            </p>
            <p> The manuscript states that suicide typology in the EMS has &#x201c;not been previously assessed in South Africa.&#x201d;</p>
            <p> This should be carefully contextualised: 
                <list list-type="bullet">
                    <list-item>
                        <p>I note that there is prior work (including by the authors) on deliberate self-harm in EMS.</p>
                    </list-item>
                    <list-item>
                        <p>The novelty lies in the typological disaggregation of suicidality and death by suicide within EMS records.</p>
                    </list-item>
                </list> Refining the novelty claim would enhance academic credibility and whilst also highlighting the authors previous contributions.</p>
            <p> </p>
            <p> 
                <bold>Conclusion</bold>
            </p>
            <p> This study provides valuable epidemiological insight into suicidality and suicide presenting to a rural South African EMS. The methodology is broadly appropriate, the findings are coherent, and the topic is highly relevant.</p>
            <p> </p>
            <p> I believe that if these recommendations are followed the manuscript will be suitable for full approval. I will be available for a quick turn around.&#x00a0;</p>
            <p> </p>
            <p> Thank you</p>
            <p> Dr. Richard Mottershead</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Partly</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Yes</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Partly</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Partly</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Reviewer Expertise:</p>
            <p>My area of research is in mental health, societial challenges, applied research</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
        <sub-article article-type="response" id="comment15510-457459">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Tilley</surname>
                            <given-names>Daniel</given-names>
                        </name>
                        <aff>Emergency Medical Science, Cape Peninsula University of Technology - Bellville Campus, Bellville, Western Cape, South Africa</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>there are no competing interests</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>22</day>
                    <month>2</month>
                    <year>2026</year>
                </pub-date>
            </front-stub>
            <body>
                <p>Please note responses are given in italics. We would like to thank the reviewer for the advice and suggestions in making this document more academically sound for international audiences and the journal. Thank you for your review.</p>
                <p> </p>
                <p> 
                    <bold>Recommendations</bold>
                </p>
                <p> 
                    <bold>1. Clarify Operational Definitions and Case Classification</bold>
                </p>
                <p> The manuscript relies on EMS categorisation (e.g., &#x201c;Self-Harm-other,&#x201d; &#x201c;Self-Harm-poisoning,&#x201d; &#x201c;Psychiatric/Behavioural Problems&#x201d;), which are not clinical diagnoses.</p>
                <p> To strengthen methodological clarity, the authors should:</p>
                <p> </p>
                <p> Provide clearer operational definitions of: 
                    <list list-type="bullet">
                        <list-item>
                            <p>Suicidal ideation</p>
                        </list-item>
                        <list-item>
                            <p>Attempted suicide</p>
                        </list-item>
                        <list-item>
                            <p>Death by suicide</p>
                        </list-item>
                        <list-item>
                            <p>Explain how misclassification bias may influence estimates.</p>
                        </list-item>
                        <list-item>
                            <p>Clarify how &#x201c;parasuicidal&#x201d; behaviour was differentiated from attempted suicide.</p>
                        </list-item>
                    </list> 
                    <italic>Operational definition have been placed in accordingly in the appropriate places. Misclassification bias has been defined and explained in the methodology and in the limitations. Parasuicidal has been differentiated accordingly to explain this definition accurately.</italic>
                </p>
                <p> </p>
                <p> I might suggest that call-takers are not mental health professionals, this is a critical limitation and should be foregrounded more clearly in the methods and limitations sections. Perhaps the call-takers had enhanced training which was not highlighted within the article?&#x00a0;</p>
                <p> </p>
                <p> 
                    <italic>This has been corrected and explained accordingly how dispatchers make us of caller prompts, senior medical technicians and senior paramedics to help with patient understandings. This is brought up earlier in the materials and methods sections.</italic>
                </p>
                <p> </p>
                <p> 
                    <bold>2. Strengthen Justification of the &#x201c;Syndemic&#x201d; Framing</bold>
                </p>
                <p> The syndemic concept is introduced as a major theoretical contribution; however, it is not analytically tested within the dataset.</p>
                <p> To strengthen conceptual coherence, the authors should: 
                    <list list-type="bullet">
                        <list-item>
                            <p>Clarify whether &#x201c;syndemic&#x201d; is used as:</p>
                        </list-item>
                        <list-item>
                            <p>A theoretical lens,</p>
                        </list-item>
                        <list-item>
                            <p>A hypothesis-generating concept,</p>
                        </list-item>
                        <list-item>
                            <p>Or a demonstrated empirical finding.</p>
                        </list-item>
                        <list-item>
                            <p>Avoid implying that syndemic relationships were statistically examined unless explicitly tested.</p>
                        </list-item>
                        <list-item>
                            <p>Consider moderating the claim of novelty unless the framework is analytically integrated into results.</p>
                        </list-item>
                    </list> Currently, the syndemic argument is persuasive but somewhat aspirational rather than empirically grounded in the presented analysis.</p>
                <p> </p>
                <p> 
                    <italic>This has been described better in the text as a theoretical lens and better explained in the discussion and moves away from the suggestion that this concept was analyzed.&#x00a0;</italic>
                </p>
                <p> </p>
                <p> 
                    <bold>3. Moderate Claims of Novelty</bold>
                </p>
                <p> The manuscript states that suicide typology in the EMS has &#x201c;not been previously assessed in South Africa.&#x201d;</p>
                <p> This should be carefully contextualised: 
                    <list list-type="bullet">
                        <list-item>
                            <p>I note that there is prior work (including by the authors) on deliberate self-harm in EMS.</p>
                        </list-item>
                        <list-item>
                            <p>The novelty lies in the typological disaggregation of suicidality and death by suicide within EMS records.</p>
                        </list-item>
                    </list> Refining the novelty claim would enhance academic credibility and whilst also highlighting the authors previous contributions.</p>
                <p> </p>
                <p> 
                    <italic>Thank you so much for this advice. and for providing us with a better novelty claim. This has been amended accordingly&#x00a0;</italic>
                </p>
            </body>
        </sub-article>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report446906">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.194504.r446906</article-id>
            <title-group>
                <article-title>Reviewer response for version 2</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Sookram</surname>
                        <given-names>Paul</given-names>
                    </name>
                    <xref ref-type="aff" rid="r446906a1">1</xref>
                    <role>Referee</role>
                </contrib>
                <aff id="r446906a1">
                    <label>1</label>University of the Free State, Bloemfontein, Free State, South Africa</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>23</day>
                <month>1</month>
                <year>2026</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2026 Sookram P</copyright-statement>
                <copyright-year>2026</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport446906" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.171712.2"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>This manuscript addresses an important and under-researched EMS public health issue using a large retrospective dataset. The methodology is appropriate, and the analyses are robust. Minor revisions are required to improve language clarity, methodological transparency, and consistency in terminology and statistical reporting</p>
            <p> </p>
            <p> 2. Language, spelling, and style (minor but frequent issues)</p>
            <p> General comments</p>
            <p> The manuscript is generally readable, but there are numerous typographical, spacing, and grammatical inconsistencies. Several errors appear repeatedly and should be corrected globally.</p>
            <p> Key issues and examples</p>
            <p> Spacing and typographical errors</p>
            <p> Examples:</p>
            <p> &#x201c;Southj african&#x201d; &#x2192; South African</p>
            <p> &#x201c;theAfrica region&#x201d; &#x2192; the Africa region</p>
            <p> &#x201c;attemptedmurders&#x201d; &#x2192; attempted murders</p>
            <p> &#x201c;healthcare&#x201d; vs &#x201c;health care&#x201d; &#x2192; choose one and apply consistently (journal style usually prefers health care).</p>
            <p> &#x201c;multinomial&#x201d; misspelled as multinominal in several places.</p>
            <p> </p>
            <p> Inconsistent capitalisation</p>
            <p> &#x201c;Death by Suicide&#x201d;, &#x201c;Attempted Suicide&#x201d;, &#x201c;Suicide&#x201d; are capitalised inconsistently.</p>
            <p> Recommendation: only capitalise when starting a sentence or when formally defining a variable.</p>
            <p> </p>
            <p> Long and complex sentences</p>
            <p> Some paragraphs (especially Introduction and Discussion) would benefit from sentence shortening to improve clarity.</p>
            <p> </p>
            <p> Example: paragraphs discussing social determinants and syndemic theory could be split.</p>
            <p> </p>
            <p> Redundancy</p>
            <p> Repetition of phrases such as &#x201c;prehospital Emergency Medical Services&#x201d; could be reduced after first definition (EMS).</p>
            <p> </p>
            <p> Recommendation:</p>
            <p> A professional language edit or journal copy-edit pass would substantially improve readability but is not a fatal flaw.</p>
            <p> </p>
            <p> 3. Introduction and literature framing</p>
            <p> Strengths</p>
            <p> </p>
            <p> Strong contextualization of suicide as a public health problem in South Africa. Effective linkage between social determinants, mental health systems, and EMS burden.The introduction of syndemic theory is novel and relevant.</p>
            <p> </p>
            <p> Areas for improvement</p>
            <p> Overcrowding of statistics</p>
            <p> The Introduction contains many statistics in a short span. Suggest prioritising key figures and moving some contextual data to later paragraphs.</p>
            <p> </p>
            <p> Clearer research gap</p>
            <p> The research gap is implied but could be stated more explicitly: &#x201c;There is limited empirical evidence describing suicidality typology within South African prehospital EMS settings.&#x201d;</p>
            <p> </p>
            <p> Research question clarity</p>
            <p> The question is posed mid-paragraph.</p>
            <p> </p>
            <p> Recommend explicitly stating the aim and objectives at the end of the Introduction.</p>
            <p> </p>
            <p> 4. Methodology</p>
            <p> </p>
            <p> Strengths</p>
            <p> </p>
            <p> Appropriate retrospective cross-sectional design.</p>
            <p> Census approach strengthens internal validity.</p>
            <p> Clear description of data source (IMRs). Ethical approvals are well documented. Methodological concerns and suggestions Inclusion/exclusion criteria</p>
            <p> Inclusion criteria rely heavily on dispatcher categorisation.</p>
            <p> </p>
            <p> This limitation is acknowledged later but should be more explicitly stated upfront.</p>
            <p> Definition of outcomes</p>
            <p> &#x201c;Death by suicide&#x201d; is defined as a prehospital service category, not forensic confirmation.</p>
            <p> </p>
            <p> This is appropriate but must be clearly emphasised earlier, especially for international readers.</p>
            <p> </p>
            <p> Use of multiple statistical tests</p>
            <p> While the analyses are appropriate, the rationale for each test could be more succinct. Consider a short summary table or paragraph explaining: Which tests answer which research questions.</p>
            <p> Multiple comparisons</p>
            <p> Given the number of tests run, there is risk of type I error. A brief statement acknowledging this limitation would strengthen the methodology.</p>
            <p> </p>
            <p> 5. Results</p>
            <p> Strengths</p>
            <p> Results are comprehensive and logically ordered.</p>
            <p> Tables and figures support the narrative. Gender and method associations are clearly reported. Issues requiring correction or clarification Consistency in reporting percentages Percentages sometimes lack denominators. Always specify n/N for clarity.</p>
            <p> Terminology</p>
            <p> &#x201c;Strangulation death&#x201d; may be misinterpreted internationally.</p>
            <p> </p>
            <p> Suggest:</p>
            <p> &#x201c;Strangulation (asphyxiation/hanging)&#x201d; on first use.</p>
            <p> Age modelling</p>
            <p> The quadratic age analysis is well executed. However, the clinical or practical significance of the peak at age 41 could be briefly contextualised. Combining attempted suicide and suicide. Combining cases for multinomial analysis is justified statistically.This decision should be explicitly justified earlier in the Results section.</p>
            <p> </p>
            <p> 6. Discussion</p>
            <p> Strengths</p>
            <p> Discussion aligns well with results.Good integration with international literature.</p>
            <p> </p>
            <p> Strong EMS-focused interpretation.The link to trauma-informed care is appropriate and timely.</p>
            <p> </p>
            <p> Areas for strengthening</p>
            <p> </p>
            <p> Balance</p>
            <p> Discussion occasionally leans toward advocacy. Consider tightening language to maintain a neutral scholarly tone.</p>
            <p> Causality- Avoid language that implies causation from cross-sectional data. Use phrases such as &#x201c;associated with&#x201d; rather than &#x201c;leads to&#x201d;.</p>
            <p> </p>
            <p> Syndemic framing- Strong conceptually, but could benefit from: A short paragraph explaining how EMS policy or training could operationalise a syndemic approach.</p>
            <p> </p>
            <p> 7. Limitations</p>
            <p> Strengths-Limitations are acknowledged and appropriate.</p>
            <p> </p>
            <p> Suggested additions-Add explicit mention of: Potential misclassification bias. Reliance on dispatcher-reported categories. Lack of post-event outcome verification</p>
            <p> </p>
            <p> 8. Referencing and citations</p>
            <p> Strengths</p>
            <p> Broad and relevant reference base. Good use of African and international literature.</p>
            <p> </p>
            <p> Issues- Inconsistency in formatting.Some references lack page numbers or consistent journal formatting.</p>
            <p> </p>
            <p> Grey literature-Media sources (e.g. Mail &amp; Guardian, Action Society) are useful but should be clearly framed as contextual sources, not epidemiological evidence.</p>
            <p> </p>
            <p> Repetition-Some references appear multiple times in the reference list (likely formatting duplication</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Yes</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Yes</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Yes</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Yes</p>
            <p>Reviewer Expertise:</p>
            <p>I am an expert in Health Professions Education</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.</p>
        </body>
        <sub-article article-type="response" id="comment15509-446906">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Tilley</surname>
                            <given-names>Daniel</given-names>
                        </name>
                        <aff>Emergency Medical Science, Cape Peninsula University of Technology - Bellville Campus, Bellville, Western Cape, South Africa</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>no competing interests</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>22</day>
                    <month>2</month>
                    <year>2026</year>
                </pub-date>
            </front-stub>
            <body>
                <p>Please see comments in Italics. We would like to thank the reviewer for all the positive suggestions and advice in making this article more academic sound and applicable to international standards for the journal. Thank you</p>
                <p> </p>
                <p> 2. Language, spelling, and style (minor but frequent issues)</p>
                <p> General comments</p>
                <p> The manuscript is generally readable, but there are numerous typographical, spacing, and grammatical inconsistencies. Several errors appear repeatedly and should be corrected globally.</p>
                <p> Key issues and examples</p>
                <p> Spacing and typographical errors</p>
                <p> Examples:</p>
                <p> &#x201c;Southj african&#x201d; &#x2192; South African</p>
                <p> &#x201c;theAfrica region&#x201d; &#x2192; the Africa region</p>
                <p> &#x201c;attemptedmurders&#x201d; &#x2192; attempted murders</p>
                <p> &#x201c;healthcare&#x201d; vs &#x201c;health care&#x201d; &#x2192; choose one and apply consistently (journal style usually prefers health care).</p>
                <p> &#x201c;multinomial&#x201d; misspelled as multinominal in several places.</p>
                <p> </p>
                <p> 
                    <italic>Thank you for this report. This has been fix and changed accordingly.</italic>
                </p>
                <p> </p>
                <p> Inconsistent capitalisation</p>
                <p> &#x201c;Death by Suicide&#x201d;, &#x201c;Attempted Suicide&#x201d;, &#x201c;Suicide&#x201d; are capitalised inconsistently.</p>
                <p> Recommendation: only capitalise when starting a sentence or when formally defining a variable.</p>
                <p> </p>
                <p> 
                    <italic>This has been changed in the document and corrected accordingly</italic>
                </p>
                <p> </p>
                <p> Long and complex sentences</p>
                <p> Some paragraphs (especially Introduction and Discussion) would benefit from sentence shortening to improve clarity.</p>
                <p> </p>
                <p> Example: paragraphs discussing social determinants and syndemic theory could be split.</p>
                <p> </p>
                <p> 
                    <italic>The long paragraphs have been shortened in to smaller coherent sentences and split accordingly.</italic>
                </p>
                <p> </p>
                <p> Redundancy</p>
                <p> Repetition of phrases such as &#x201c;prehospital Emergency Medical Services&#x201d; could be reduced after first definition (EMS).</p>
                <p> </p>
                <p> 
                    <italic>This has been corrected accordingly</italic>
                </p>
                <p> </p>
                <p> Recommendation:</p>
                <p> A professional language edit or journal copy-edit pass would substantially improve readability but is not a fatal flaw.</p>
                <p> </p>
                <p> .</p>
                <p> Clearer research gap</p>
                <p> The research gap is implied but could be stated more explicitly: &#x201c;There is limited empirical evidence describing suicidality typology within South African prehospital EMS settings.&#x201d;</p>
                <p> </p>
                <p> 
                    <italic>This has been added. Thank you for pointing this out and aiding in a contextualizing sentence, that we added to the manuscript.</italic>
                </p>
                <p> </p>
                <p> Research question clarity</p>
                <p> The question is posed mid-paragraph.</p>
                <p> </p>
                <p> Recommend explicitly stating the aim and objectives at the end of the Introduction.</p>
                <p> </p>
                <p> 
                    <italic>This has been rearranged and fixed accordingly.</italic>
                </p>
                <p> </p>
                <p> 4. Methodology</p>
                <p> </p>
                <p> This limitation is acknowledged later but should be more explicitly stated upfront.</p>
                <p> Definition of outcomes</p>
                <p> &#x201c;Death by suicide&#x201d; is defined as a prehospital service category, not forensic confirmation.</p>
                <p> </p>
                <p> This is appropriate but must be clearly emphasised earlier, especially for international readers.</p>
                <p> </p>
                <p> 
                    <italic>We added this in earlier as suggested</italic>
                </p>
                <p> </p>
                <p> Use of multiple statistical tests</p>
                <p> While the analyses are appropriate, the rationale for each test could be more succinct. Consider a short summary table or paragraph explaining: Which tests answer which research questions.</p>
                <p> Multiple comparisons</p>
                <p> Given the number of tests run, there is risk of type I error. A brief statement acknowledging this limitation would strengthen the methodology.</p>
                <p> </p>
                <p> 
                    <italic>This is added and we explain how&#x00a0;Tukey&#x2019;s method is designed to control the familywise type I error rate at a fixed level (e.g., 0.05) despite the large number of pairwise comparisons being made.</italic>
                </p>
                <p> </p>
                <p> Suggest:</p>
                <p> &#x201c;Strangulation (asphyxiation/hanging)&#x201d; on first use.</p>
                <p> </p>
                <p> 
                    <italic>This has been changed throughout document</italic>
                </p>
                <p> </p>
                <p> Age modelling</p>
                <p> The quadratic age analysis is well executed. However, the clinical or practical significance of the peak at age 41 could be briefly contextualised. Combining attempted suicide and suicide. Combining cases for multinomial analysis is justified statistically.This decision should be explicitly justified earlier in the Results section.</p>
                <p> </p>
                <p> 
                    <italic>This is done accordingly</italic>
                </p>
                <p> </p>
                <p> 6. Discussion</p>
                <p> Areas for strengthening</p>
                <p> </p>
                <p> Balance</p>
                <p> Discussion occasionally leans toward advocacy. Consider tightening language to maintain a neutral scholarly tone.</p>
                <p> Causality- Avoid language that implies causation from cross-sectional data. Use phrases such as &#x201c;associated with&#x201d; rather than &#x201c;leads to&#x201d;.</p>
                <p> </p>
                <p> 
                    <italic>This has been done accordingly</italic>
                </p>
                <p> </p>
                <p> Syndemic framing- Strong conceptually, but could benefit from: A short paragraph explaining how EMS policy or training could operationalise a syndemic approach.</p>
                <p> </p>
                <p> 
                    <italic>This has been added accordingly as suggested</italic>
                </p>
                <p> </p>
                <p> 7. Limitations</p>
                <p> Strengths-Limitations are acknowledged and appropriate.</p>
                <p> </p>
                <p> Suggested additions-Add explicit mention of: Potential misclassification bias. Reliance on dispatcher-reported categories. Lack of post-event outcome verification</p>
                <p> </p>
                <p> 
                    <italic>This has been done and explained in limitations and in methodology section. As suggested</italic>
                </p>
                <p> </p>
                <p> 8. Referencing and citations</p>
                <p> </p>
                <p> Issues- Inconsistency in formatting.Some references lack page numbers or consistent journal formatting.</p>
                <p> </p>
                <p> 
                    <italic>This is how the journal created the referencing format. APA was used as the initial reference format</italic>
                </p>
                <p> </p>
                <p> Grey literature-Media sources (e.g. Mail &amp; Guardian, Action Society) are useful but should be clearly framed as contextual sources, not epidemiological evidence.</p>
                <p> </p>
                <p> 
                    <italic>done accordingly</italic>
                </p>
                <p> </p>
                <p> Repetition-Some references appear multiple times in the reference list (likely formatting duplication</p>
                <p> </p>
                <p> 
                    <italic>This duplication is in requirements of the journal for data availability and is part of the instructions to create a DOI and add a reference to the reference list.</italic>
                </p>
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        </sub-article>
    </sub-article>
</article>
