<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN" "http://jats.nlm.nih.gov/publishing/1.2/JATS-journalpublishing1.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="research-article" dtd-version="1.2" xml:lang="en">
    <front>
        <journal-meta>
            <journal-id journal-id-type="pmc">F1000Research</journal-id>
            <journal-title-group>
                <journal-title>F1000Research</journal-title>
            </journal-title-group>
            <issn pub-type="epub">2046-1402</issn>
            <publisher>
                <publisher-name>F1000 Research Limited</publisher-name>
                <publisher-loc>London, UK</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="doi">10.12688/f1000research.163191.1</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Research Article</subject>
                </subj-group>
                <subj-group>
                    <subject>Articles</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Stapled Versus Conventional Hemorrhoidectomy: A Retrospective Study and Comparative Analysis of Outcomes</article-title>
                <fn-group content-type="pub-status">
                    <fn>
                        <p>[version 1; peer review: 1 approved with reservations, 1 not approved]</p>
                    </fn>
                </fn-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Shweliya</surname>
                        <given-names>Mohammedsadeq A.</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Project Administration</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <uri content-type="orcid">https://orcid.org/0009-0000-2832-6270</uri>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Al-Hamdany</surname>
                        <given-names>Arkan Shubber AbdulKhaliq</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Resources</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="aff" rid="a2">2</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Ahmed</surname>
                        <given-names>Marafi Jammaa Ismail</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0009-0000-5032-8627</uri>
                    <xref ref-type="aff" rid="a3">3</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Shimal</surname>
                        <given-names>Aya Ahmed</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <uri content-type="orcid">https://orcid.org/0009-0002-0268-236X</uri>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Hamzah</surname>
                        <given-names>Khadeeja Ali</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <uri content-type="orcid">https://orcid.org/0009-0009-2674-4829</uri>
                    <xref ref-type="aff" rid="a4">4</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Eladl</surname>
                        <given-names>Hassan H.</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0009-0005-2003-1159</uri>
                    <xref ref-type="aff" rid="a5">5</xref>
                </contrib>
                <contrib contrib-type="author" corresp="yes">
                    <name>
                        <surname>Hemmeda</surname>
                        <given-names>Lina</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0003-4636-9471</uri>
                    <xref ref-type="corresp" rid="c1">a</xref>
                    <xref ref-type="aff" rid="a6">6</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Alsaadi</surname>
                        <given-names>Mustafa Haleem</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="aff" rid="a7">7</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Mahgoub</surname>
                        <given-names>Abdulhadi M. A.</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0009-0004-5008-940X</uri>
                    <xref ref-type="aff" rid="a8">8</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Aamer</surname>
                        <given-names>Yusur</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Resources</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0009-0000-2832-6270</uri>
                    <xref ref-type="aff" rid="a9">9</xref>
                </contrib>
                <aff id="a1">
                    <label>1</label>University of Baghdad, Baghdad, Baghdad Governorate, Iraq</aff>
                <aff id="a2">
                    <label>2</label>Iraqi Ministry of Health, Karbala Health Directorate, General and Laparoscopic Surgeon, Karbala, Iraq</aff>
                <aff id="a3">
                    <label>3</label>Bahri University, Khartoum, Sudan</aff>
                <aff id="a4">
                    <label>4</label>University of Baghdad Al-Kindy College Of Medicine, Baghdad, Iraq</aff>
                <aff id="a5">
                    <label>5</label>Ain Shams University, Cairo, Cairo Governorate, Egypt</aff>
                <aff id="a6">
                    <label>6</label>University of Khartoum, Khartoum, Khartoum, Sudan</aff>
                <aff id="a7">
                    <label>7</label>Jabir Ibn Hayyan University for Medical and Pharmaceutical Sciences, Najaf, Iraq</aff>
                <aff id="a8">
                    <label>8</label>University of Gezira, Wad Madani, Al Jazirah, Sudan</aff>
                <aff id="a9">
                    <label>9</label>Mustansiriyah University, Baghdad, Baghdad Governorate, Iraq</aff>
            </contrib-group>
            <author-notes>
                <corresp id="c1">
                    <label>a</label>
                    <email xlink:href="mailto:lina.hemmeda@gmail.com">lina.hemmeda@gmail.com</email>
                </corresp>
                <fn fn-type="conflict">
                    <p>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>19</day>
                <month>6</month>
                <year>2025</year>
            </pub-date>
            <pub-date pub-type="collection">
                <year>2025</year>
            </pub-date>
            <volume>14</volume>
            <elocation-id>601</elocation-id>
            <history>
                <date date-type="accepted">
                    <day>30</day>
                    <month>5</month>
                    <year>2025</year>
                </date>
            </history>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2025 Shweliya MA et al.</copyright-statement>
                <copyright-year>2025</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <self-uri content-type="pdf" xlink:href="https://f1000research.com/articles/14-601/pdf"/>
            <abstract>
                <sec>
                    <title>Background</title>
                    <p>Anorectal hemorrhoids are a common condition that frequently needs surgery in more challenging situations. Both stapled hemorrhoidectomy and conventional hemorrhoidectomy are standard surgical procedures, each one with various advantages and disadvantages as well. The purpose of this study is to compare the outcomes of these two operations concerning patient satisfaction, complications, recovery time and postoperative pain.</p>
                </sec>
                <sec>
                    <title>Method</title>
                    <p>This retrospective cohort analysis was conducted in Karbala, Iraq, at AL-Kafeel Hospital and AL-Safeer Hospital. Information has been collected from patients who had stapled hemorrhoidectomy in 2023&#x2013;2024 and those who had conventional hemorrhoidectomy from 2015&#x2013;2018. To account for baseline variations, especially those related to the kind of anesthetic and extent of hemorrhoids, propensity score matching (caliper = 0.05) was employed. SPSS version 29.0 was used for statistical analysis, and comparisons were made by using t-tests, chi-square tests, and correlation analyses. Statistical significance was defined as a p-value of less than 0.05.</p>
                </sec>
                <sec>
                    <title>Results</title>
                    <p>Out of 114 patients (50 conventional, 64 stapled), the stapled group had a higher percentage of fourth-degree hemorrhoids, postoperative pain and bleeding were significantly lower in the stapled group (p &lt; 0.001), and only the conventional group had wound infections and anal stenosis (p &lt; 0.05). The stapled group also showed better postoperative outcomes.</p>
                </sec>
                <sec>
                    <title>Conclusion</title>
                    <p>Stapled hemorrhoidectomy is linked to less pain, fewer complications, and faster recovery than conventional hemorrhoidectomy, but the risk of recurrent hemorrhoidectomy is still a concern. These findings support that surgical decision-making in hemorrhoid management can be optimized.</p>
                </sec>
            </abstract>
            <kwd-group kwd-group-type="author">
                <kwd>Hemorrhoidectomy; Stapled hemorrhoidectomy; Conventional hemorrhoidectomy; Surgical outcomes; Complications; Postoperative pain</kwd>
            </kwd-group>
            <funding-group>
                <funding-statement>The author(s) declared that no grants were involved in supporting this work.</funding-statement>
            </funding-group>
        </article-meta>
    </front>
    <body>
        <sec id="sec5" sec-type="intro">
            <title>Introduction</title>
            <p>Hemorrhoids, commonly known as piles, are severely swollen veins that have formed in the lower rectum or the anus. They are of two types: internal and external. Internal ones develop within the rectum and are usually painless. They can lead to rectal bleeding. They may also prolapse, which is when the hemorrhoids come out through the anus.</p>
            <p>On the other hand, the skin beneath the anus is home to external hemorrhoids, which can cause swelling, pain, and itching.
                <sup>
                    <xref ref-type="bibr" rid="ref1">1</xref>,
                    <xref ref-type="bibr" rid="ref2">2</xref>
                </sup> Risk factors include pregnancy, family history, aging, obesity, low-fiber diet, sedentary lifestyle, heavy lifting, and chronic constipation or diarrhea.
                <sup>
                    <xref ref-type="bibr" rid="ref3">3</xref>,
                    <xref ref-type="bibr" rid="ref4">4</xref>
                </sup> Studies show that nearly 5% of the global population suffers from symptomatic hemorrhoids, with higher prevalences in developed countries.
                <sup>
                    <xref ref-type="bibr" rid="ref5">5</xref>
                </sup> People suffering from hemorrhoids complain of factors such as pain, discomfort, itching, and even bleeding, which makes it difficult for them to carry out their daily activities as well as social life. This may lead to physical and psychological problems such as anxiety and depression because they tend to feel embarrassed.
                <sup>
                    <xref ref-type="bibr" rid="ref6">6</xref>
                </sup> The Goligher grading system classifies internal hemorrhoids into four grades based on prolapse severity. Grade I is asymptomatic, while Grade II prolapses after bowel movements but reduces spontaneously. Grade III requires manual reduction, and Grade IV remains prolapsed.
                <sup>
                    <xref ref-type="bibr" rid="ref7">7</xref>
                </sup> Treatment varies by severity. Early-stage cases are managed with lifestyle modifications and analgesics.
                <sup>
                    <xref ref-type="bibr" rid="ref8">8</xref>
                </sup> Minimally invasive procedures like sclerotherapy, infrared photocoagulation, and rubber band ligation are options for advanced cases.
                <sup>
                    <xref ref-type="bibr" rid="ref9">9</xref>
                </sup> Severe or chronic hemorrhoids often require surgery, primarily conventional or stapled hemorrhoidectomy.
                <sup>
                    <xref ref-type="bibr" rid="ref10">10</xref>
                </sup> In conventional hemorrhoidectomy, the hemorrhagic tissues are removed under local, regional, or general anesthesia during the surgery. It may be done using a laser or a scalpel with the wound either sutured or left open. It&#x2019;s found to be effective for Grade III and IV hemorrhoids but is associated with significant postoperative pain and a lengthy recovery period of two to six weeks.
                <sup>
                    <xref ref-type="bibr" rid="ref11">11</xref>
                </sup> In contrast, stapled hemorrhoidectomy, which uses a circular stapler to remove extra tissue and realign hemorrhoids while under general anesthesia, has a greater recurrence rate but is less painful and heals more quickly.
                <sup>
                    <xref ref-type="bibr" rid="ref12">12</xref>,
                    <xref ref-type="bibr" rid="ref13">13</xref>
                </sup> The classical technique, introduced in 1993, treats hemorrhoidal disease through stapled hemorrhoidopexy, a less invasive alternative to traditional hemorrhoidectomy. It offers better pain control and patient comfort but carries risks of complications like bleeding and sepsis. Since 2002, over 130 studies have reported these risks, emphasizing the need for careful comparison with conventional hemorrhoidectomy.
                <sup>
                    <xref ref-type="bibr" rid="ref14">14</xref>
                </sup>
            </p>
            <p>The choice between conventional and stapled hemorrhoidectomy remains challenging due to variations in pain levels, recovery time. Limited and mostly outdated studies have explored this topic, with none conducted in Iraq, leaving a gap in understanding patient outcomes and long-term effectiveness in our clinical setting.</p>
            <p>This research aims to compare the outcomes between stapled and conventional hemorrhoidectomy techniques by evaluating postoperative pain, recovery time, and complications. The study seeks to provide evidence-based data to guide surgical decision-making and optimize treatment selection for patients requiring hemorrhoid surgery in our clinical setting.</p>
        </sec>
        <sec id="sec6" sec-type="methods">
            <title>Methods</title>
            <p>This study is a retrospective analysis of prospectively collected data from two centers: AL-Kafeel Hospital and Safeer Al-Hussain Hospital in Karbala, Iraq. The aim was to compare the outcomes and complications of conventional hemorrhoidectomy and stapled hemorrhoidectomy.</p>
            <sec id="sec7">
                <title>Patients</title>
                <p>These data were collected by teams of two surgeons for their patients between September 2015 and January 2024. We included patients older than 18 years old, with grade three or four hemorrhoids, complete medical records, and who underwent surgical intervention at Al-Kafeel Hospital and Al-Safeer Hospital in Karbala, Iraq.</p>
                <p>Exclusion criteria included patients with incomplete records, missing data or those for whom baseline characteristics or postoperative outcomes were unavailable, those who underwent surgery for acute cause, or those with a history of hemorrhoidectomy. Written informed consent was obtained from each patient at time of data collection.</p>
            </sec>
            <sec id="sec8">
                <title>Propensity score matching</title>
                <p>To reduce the bias in selection, propensity score matching was carried using a caliper width of 0.05. Matching was performed based on the type of anesthesia and degree of hemorrhoids to ensure that the two surgical groups would have comparable baseline characteristics.</p>
            </sec>
            <sec id="sec9">
                <title>Statistical analysis</title>
                <p>Data were analyzed using SPSS version 29.0 (
                    <ext-link ext-link-type="uri" xlink:href="https://www.ibm.com/support/pages/downloading-ibm-spss-statistics-29">https://www.ibm.com/support/pages/downloading-ibm-spss-statistics-29</ext-link>). Descriptive statistics were used to summarize the data, including mean, standard deviation, and percentages. An independent samples t-test was applied for continuous variables, while categorical variables were compared using the chi-square test. Pearson&#x2019;s and Spearman&#x2019;s correlation coefficients were calculated to assess relationships among variables. Statistical significance was established at p &lt; 0.05.</p>
            </sec>
        </sec>
        <sec id="sec10" sec-type="results">
            <title>Results</title>
            <p>In this retrospective study involving 114 participants, 50 (43%) were in the classical group, while 64 (56%) were in the stapled group. Among both groups, 35 participants (30%) were female, and 79 (69%) were male. The mean age of the classical group was 42 years, while the mean age of the stapled group was 43 years. The age distribution among the study groups followed a normal distribution, and there was no statistically significant difference in age between the groups, see 
                <xref ref-type="table" rid="T1">
Table 1</xref>. Age was categorized into multiple groups for analytical purposes. At baseline, the stapled group exhibited a higher proportion of fourth-degree cases than those with third-degree cases, as can be seen in 
                <xref ref-type="table" rid="T2">
Table 2</xref> and 
                <xref ref-type="fig" rid="f1">
Figure 1</xref>.</p>
            <table-wrap id="T1" orientation="portrait" position="float">
                <label>
Table 1. </label>
                <caption>
                    <title>Age distribution of unmatched cohort.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1" valign="top">Age in Years</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Classical, n = 50</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">%</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Stapled, n = 64</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">%</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">
Total, n = 114</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">18-21</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">6</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">6</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">22-29</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">6</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">12</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">10</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">15</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">16</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">30-49</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">30</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">60</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">28</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">43</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">58</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">50-59</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">7</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">14</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">16</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">25</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">23</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">60-69</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">8</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">6</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">9</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">10</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">70-79</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Total</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">50</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">100</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">64</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">100</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">114</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Mean &#x00b1; SD</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">42.52 &#x00b1; 11.56</td>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="top">43.55 &#x00b1; 13.89</td>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="top">43.1 &#x00b1; 14.35</td>
                        </tr>
                    </tbody>
                </table>
                <table-wrap-foot>
                    <p>P = 0.574.</p>
                </table-wrap-foot>
            </table-wrap>
            <table-wrap id="T2" orientation="portrait" position="float">
                <label>
Table 2. </label>
                <caption>
                    <title>Baseline characteristics of unmatched cohort.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1" valign="top">Parameter</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Classical n = 50 (%)</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Stapled n = 64 (%)</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">
p-value
</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Gender</bold>
</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="top">&lt;0.001</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Female (%)</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">24 (48)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">11 (17)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Male (%)</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">26 (52)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">53 (82)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Hemorrhoids degree (%)</bold>
</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="top">&lt;0.001</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Third (%)</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">46 (92)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">41 (64)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Fourth (%)</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4 (8)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">23 (35)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Preoperative pain (%)</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">33 (66)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">34 (53)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.166</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Preoperative bleeding (%)</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">23 (46)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">39 (60)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.112</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Preoperative mass (%)</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">47 (94)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">59 (92)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.707</td>
                        </tr>
                    </tbody>
                </table>
            </table-wrap>
            <fig fig-type="figure" id="f1" orientation="portrait" position="float">
                <label>
Figure 1. </label>
                <caption>
                    <title>Showing hemorrhoid degree at presentation among the stapled and classical groups.</title>
                </caption>
                <graphic id="gr1" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/179498/5fcd4aff-5783-4830-9c2b-10f742c63cb3_figure1.gif"/>
            </fig>
            <p>Regarding the preoperative presentations, the preoperative mass was the predominant feature in the clinical presentation for both groups. This mass may be associated with bleeding or pain. The proportions of hemorrhoid severity varied between the two groups. The majority of participants presented with third-degree hemorrhoids, with 92% in the classical group compared to 64% in the stapled group, see 
                <xref ref-type="fig" rid="f2">
Figure 2</xref>. While in postoperative complications, a significant difference was observed in postoperative pain, bleeding (p = 0.001), and wound infection (p = 0.01). In the classical group, additional complications included anal stenosis. Notably, all cases of postoperative wound infection occurred in females (n = 5). In contrast, no such complications were observed in the stapled group, see 
                <xref ref-type="table" rid="T3">
Table 3</xref>, 
                <xref ref-type="fig" rid="f3">
Figure 3</xref> and 
                <xref ref-type="table" rid="T4">
Table 4</xref>. All instances of postoperative bleeding in the stapled group were reported in males (
                <xref ref-type="table" rid="T5">
Table 5</xref>).</p>
            <fig fig-type="figure" id="f2" orientation="portrait" position="float">
                <label>
Figure 2. </label>
                <caption>
                    <title>Preoperative presentation of the two study groups.</title>
                </caption>
                <graphic id="gr2" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/179498/5fcd4aff-5783-4830-9c2b-10f742c63cb3_figure2.gif"/>
            </fig>
            <table-wrap id="T3" orientation="portrait" position="float">
                <label>
Table 3. </label>
                <caption>
                    <title>Showing the type of anesthesia, operation time, and postoperative complications in the unmatched cohort.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1" valign="top">Unmatched cohort</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Classical n = 50 (%)</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Stapled n = 64 (%)</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">p-value
</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Type of anesthesia (%)</bold>
</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Spinal</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">27 (54)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">5 (7)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">&lt;0.001</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>General</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">23 (46)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">59 (92)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Operation time (minutes) (Mean &#x00b1; SD)</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">28.1 &#x00b1; 11.72</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">29.3 &#x00b1; 7.82</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.489</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Postoperative bleeding (%)</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">19 (38)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4 (6)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.001</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Postoperative pain (%)</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">50 (100)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4 (6)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.001</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Wound infection (%)</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">5 (10)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0 (0)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.01</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Residual mass (%)</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">10 (20)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4 (6)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.02</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Anal stenosis (%)</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">8 (16)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0 (0)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.001</td>
                        </tr>
                    </tbody>
                </table>
            </table-wrap>
            <fig fig-type="figure" id="f3" orientation="portrait" position="float">
                <label>
Figure 3. </label>
                <caption>
                    <title>Postoperative complications in the classical and stapled groups.</title>
                </caption>
                <graphic id="gr3" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/179498/5fcd4aff-5783-4830-9c2b-10f742c63cb3_figure3.gif"/>
            </fig>
            <table-wrap id="T4" orientation="portrait" position="float">
                <label>
Table 4. </label>
                <caption>
                    <title>Showing the type of anesthesia, operation time, and postoperative complications in the matched cohort.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1" valign="top">Matched cohort</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Classical n = 25 (%)</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Stapled n = 64 (%)</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">
p-value
</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Type of anesthesia (%)</bold>
</td>
                            <td colspan="1" rowspan="1"/>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.26</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Spinal</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4 (16)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">5 (7)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>General</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">21 (84)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">59 (92)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Operation time (minutes) (Mean &#x00b1; SD)</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">25 &#x00b1; 10.3</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">29 &#x00b1; 7.8</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.07</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Postoperative bleeding (%)</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">11 (44)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4 (6)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">&lt; 0.001</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Postoperative pain (%)</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">25 (100)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4 (6)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">&lt; 0.001</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Wound infection (%)</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3 (12)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0 (0)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.02</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Residual mass (%)</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4 (16)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4 (6)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.21</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Anal stenosis (%)</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">5 (20)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0 (0)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.001</td>
                        </tr>
                    </tbody>
                </table>
                <table-wrap-foot>
                    <p>SD: Standard deviation.</p>
                </table-wrap-foot>
            </table-wrap>
            <table-wrap id="T5" orientation="portrait" position="float">
                <label>
Table 5. </label>
                <caption>
                    <title>Postoperative complications according to the biological sex of unmatched cohort.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1" valign="top"/>
                            <th align="left" colspan="1" rowspan="1" valign="top"/>
                            <th align="left" colspan="1" rowspan="1" valign="top">Female, n = 35 (%)</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">Male, n = 79 (%)</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">
p-value
</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Postoperative bleeding</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Classical</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">11 (31)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">8 (10)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.27</td>
                        </tr>
                        <tr>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="top">Stapled</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0 (0)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4 (5)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.34</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Wound infection</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Classical</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">5 (14)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0 (0)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.02</td>
                        </tr>
                        <tr>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="top">Stapled</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0 (0)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0 (0)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Postoperative pain</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Classical</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">23 (65)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">26 (32)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                        <tr>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="top">Stapled</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0 (0)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4 (5)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.34</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Operation time (mean &#x00b1; SD)</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Classical</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">33.69 &#x00b1; 14.29</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">22.69 &#x00b1; 4.23</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">&lt;0.001</td>
                        </tr>
                        <tr>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="top">Stapled</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">30.36 &#x00b1; 6.91</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">29.06 &#x00b1; 8.07</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.620</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Residual mass (%)</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Classical</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">5 (14)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">5 (6)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1</td>
                        </tr>
                        <tr>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="top">Stapled</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0 (0)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">4 (5)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.34</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">
                                <bold>Anal stenosis (%)</bold>
</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Classical</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0 (0)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">8 (10)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.004</td>
                        </tr>
                        <tr>
                            <td colspan="1" rowspan="1"/>
                            <td align="left" colspan="1" rowspan="1" valign="top">Stapled</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0 (0)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0 (0)</td>
                            <td colspan="1" rowspan="1"/>
                        </tr>
                    </tbody>
                </table>
            </table-wrap>
        </sec>
        <sec id="sec11" sec-type="discussion">
            <title>Discussion</title>
            <p>Our findings show differences in results between stapled and conventional hemorrhoidectomy operations. The results showed less postoperative pain and fewer complications.</p>
            <p>The mean (SD) of age in our cohort was 42.52 (11.56) and 43.55 (13.89) in the classical and stapled groups, respectively, which is slightly higher than the mean age reported in a prior cohort, 40.05 years (SD = 10.88) and 39.5 years (SD = 9.82) in the classical and stapled groups, respectively.
                <sup>
                    <xref ref-type="bibr" rid="ref15">15</xref>
                </sup>
            </p>
            <p>Regarding gender distribution, our classical group had a relatively balanced composition (52% male, 48% female), whereas the stapled group had a significantly higher proportion of males (82% male, 17% female). This differs from the findings of Sachin et al. (2017), where the male-to-female ratios were 66% male, 34% female in the conventional group and 54% male and 46% female in the stapled group.
                <sup>
                    <xref ref-type="bibr" rid="ref15">15</xref>
                </sup>
            </p>
            <p>The type of anesthesia used was spinal in 54% of patients who underwent classical hemorrhoidectomy and general anesthesia in 92% of stapled hemorrhoidectomy patients. However, the significantly lower postoperative pain in the stapled hemorrhoidectomy group (p &lt; 0.001) aligns with previous studies, which attribute this to the preservation of the anoderm and perianal skin innervation.
                <sup>
                    <xref ref-type="bibr" rid="ref12">12</xref>,
                    <xref ref-type="bibr" rid="ref13">13</xref>
                </sup> Conventional hemorrhoidectomy involves excising hemorrhoidal tissue, leading to an open wound that remains exposed to irritation from stool passage, causing prolonged discomfort.
                <sup>
                    <xref ref-type="bibr" rid="ref11">11</xref>
                </sup> In contrast, stapled hemorrhoidectomy repositions rather than removes tissue.
                <sup>
                    <xref ref-type="bibr" rid="ref12">12</xref>,
                    <xref ref-type="bibr" rid="ref13">13</xref>
                </sup> This could be due to minimized nerve disruption and inflammatory response, which may explain the shorter recovery period observed in our cohort.</p>
            <p>In contrast, studies reported severe postoperative pain as one of the most common complications,
                <sup>
                    <xref ref-type="bibr" rid="ref14">14</xref>,
                    <xref ref-type="bibr" rid="ref16">16</xref>,
                    <xref ref-type="bibr" rid="ref17">17</xref>
                </sup> Still, it was powerfully explained by the incorrect indication for surgery or surgical technique or pre-existing comorbidities.
                <sup>
                    <xref ref-type="bibr" rid="ref14">14</xref>,
                    <xref ref-type="bibr" rid="ref17">17</xref>
                </sup> However, other studies have shown that stapled hemorrhoidectomy reduces hospitalization length and lowers the need for postoperative analgesics.
                <sup>
                    <xref ref-type="bibr" rid="ref18">18</xref>&#x2013;
                    <xref ref-type="bibr" rid="ref20">20</xref>
                </sup>
            </p>
            <p>Our study confirmed that wound infection anal stenosis were exclusively seen in the conventional hemorrhoidectomy group (p &lt; 0.05), which are common complications known to be associated with conventional hemorrhoidectomy.
                <sup>
                    <xref ref-type="bibr" rid="ref21">21</xref>,
                    <xref ref-type="bibr" rid="ref22">22</xref>
                </sup> This may be due to open wounds being prone to bacterial colonization, tissue fibrosis, and subsequent scarring.
                <sup>
                    <xref ref-type="bibr" rid="ref23">23</xref>
                </sup>
            </p>
            <p>There were no notable distinctions between males and females in most of the postoperative complications. Interestingly, our results showed a higher rate of wound infections in females (p = 0.02) and anal stenosis in males (p = 0.004). The reason for this disparity is unclear but may be linked to anatomical variations in pelvic floor structure, wound healing response, and hormonal influences.</p>
            <p>In our study, the mean surgical duration was 28.1 &#x00b1; 11.72 minutes in the classical group and 29.3 &#x00b1; 7.82 minutes in the stapled group, with significantly longer times in females (P &lt; 0.001). Similarly, there was no significant difference in operative time (P = 0.082) or blood loss (P = 0.117), but shorter hospital stays in the stapled group (P &lt; 0.001) (19). Conversely, Toppo et al. (2023) found shorter operative times for stapled (28.71 &#x00b1; 7.25 min) vs. open hemorrhoidectomy (36.51 &#x00b1; 9.16 min)
                <sup>
                    <xref ref-type="bibr" rid="ref24">24</xref>
                </sup> gender disparity in our classical group underscores the importance of considering patient demographics when evaluating surgical outcomes.</p>
            <p>Although the stapled hemorrhoidectomy technique is generally considered safer with a lower complication rate, It has been linked to a higher chance of incontinence and higher recurrence rates, as confirmed by previous studies.
                <sup>
                    <xref ref-type="bibr" rid="ref19">19</xref>,
                    <xref ref-type="bibr" rid="ref25">25</xref>,
                    <xref ref-type="bibr" rid="ref26">26</xref>
                </sup> This suggests that while the stapled technique may offer short-term benefits in terms of safety, long-term outcomes should be carefully considered, particularly in high-risk populations. A national study, for instance, found that advanced age combined with comorbidities significantly increased postoperative risks in hemorrhoidectomy patients.
                <sup>
                    <xref ref-type="bibr" rid="ref27">27</xref>
                </sup> Further, a study linked complications like pain, bleeding, and stricture to pre-existing conditions, highlighting the need for careful patient assessment.
                <sup>
                    <xref ref-type="bibr" rid="ref17">17</xref>
                </sup>
            </p>
            <sec id="sec12">
                <title>Limitations</title>
                <p>The analysis is limited by its retrospective observational design and the small sample size, which could affect the data&#x2019;s generalizability. Complication assessment was restricted to admission duration without long-term follow-up to evaluate recurrence rates or patient satisfaction. While longer follow-ups would provide more detailed information, logistical issues with patient attrition in retrospective studies usually limit long-term data. Lastly, while the research emphasizes safety outcomes, efficacy measures of functional recovery and recurrence prevention were not exhaustively examined. Prospective design studies with extended follow-ups must be done in the future to address these deficiencies.</p>
            </sec>
            <sec id="sec13">
                <title>Strength</title>
                <p>One of the biggest strengths of this study is the simple comparison between two prevalent surgical techniques, which will prove to be very helpful in clinical practice. Patients from two hospitals provide more generalizability of the findings to various populations. The study also collects a lot of preoperative, postoperative, and demographic data. Propensity score matching also enhances reliable outcome measurements and removes some selection bias.</p>
            </sec>
            <sec id="sec14">
                <title>Future implications</title>
                <p>Additional research should evaluate both procedures&#x2019; long-term efficacy, particularly for recurrence and patient satisfaction. Cost-effectiveness analysis of stapled vs. conventional hemorrhoidectomy would help establish optimized resource utilization. From high-risk groups, including those with significant comorbidities, more targeted surgical recommendations can be developed. More extensive research with longer follow-up is needed to refine the treatment further and improve patients&#x2019; outcomes.</p>
            </sec>
        </sec>
        <sec id="sec15" sec-type="conclusion">
            <title>Conclusion</title>
            <p>This study demonstrates that stapled hemorrhoidectomy is better than conventional hemorrhoidectomy in that it causes less postoperative pain, fewer complications, and faster recovery. The high recurrence rate is problematic. These findings suggest that surgical management should be tailored based on disease severity and patient preference. Further studies with more extensive series and longer follow-ups are required to validate these observations and guide the optimal surgical treatment for hemorrhoidal disease.</p>
        </sec>
        <sec id="sec16">
            <title>Ethical considerations</title>
            <p>Ethical approval was taken from the &#x201c;Research Unite at Karbala Health Directorate&#x201d; in February 2025. No approval number was provided. Patient confidentiality was maintained throughout the study. This study was conducted in accordance with the ethical standards of the Declaration of Helsinki.</p>
        </sec>
        <sec id="sec17">
            <title>Consent</title>
            <p>Written informed consent was obtained from each patient at time of data collection.</p>
        </sec>
        <sec id="sec18">
            <title>Preregistered data analysis</title>
            <p>This retrospective study has not been preregistered at any site previously, as retrospective registration is not permitted.</p>
        </sec>
    </body>
    <back>
        <sec id="sec21" sec-type="data-availability">
            <title>Data availability</title>
            <sec id="sec22">
                <title>Underlying data</title>
                <p>Zenodo: stapled vs classical.xlsx. 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.5281/zenodo.15380704">https://doi.org/10.5281/zenodo.15380704</ext-link>.
                    <sup>
                        <xref ref-type="bibr" rid="ref28">28</xref>
                    </sup>
                </p>
                <p>This project contains the following underlying data:
                    <list list-type="bullet">
                        <list-item>
                            <label>&#x2022;</label>
                            <p>stapled vs classical.xlsx. (This contains values of stapled and classical surgeries)</p>
                        </list-item>
                    </list>
                </p>
                <p>Data are available under the terms of the 
                    <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International license</ext-link> (CC-BY 4.0).</p>
            </sec>
            <sec id="sec23">
                <title>Extended data</title>
                <p>Zenodo: stapled vs classical.xlsx. 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.5281/zenodo.15380704">https://doi.org/10.5281/zenodo.15380704</ext-link>.
                    <sup>
                        <xref ref-type="bibr" rid="ref28">28</xref>
                    </sup>
                </p>
                <p>This project contains the following underlying data:
                    <list list-type="bullet">
                        <list-item>
                            <label>&#x2022;</label>
                            <p>Age as a continous Variable (2).xlsx. (This contains the age variable as a continuous data variable)</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>STROBE-checklist-v4-combined.doc (This contains STROBE checklist)</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>

                                <ext-link ext-link-type="uri" xlink:href="https://zenodo.org/records/15380704/files/sheet.pdf?download=1">sheet.pdf</ext-link> (This contains participants information sheet)</p>
                        </list-item>
                        <list-item>
                            <label>&#x2022;</label>
                            <p>

                                <ext-link ext-link-type="uri" xlink:href="https://zenodo.org/records/15380704/files/patient%20consent%20form%20sample.pdf?download=1">patient consent form sample.pdf</ext-link> (This contains blank consent form)</p>
                        </list-item>
                    </list>
                </p>
                <p>Data are available under the terms of the 
                    <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International license</ext-link> (CC-BY 4.0).</p>
            </sec>
        </sec>
        <ack>
            <title>Acknowledgments</title>
            <p>Not applicable.</p>
        </ack>
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    <sub-article article-type="reviewer-report" id="report442172">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.179498.r442172</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Gambardella</surname>
                        <given-names>Claudio</given-names>
                    </name>
                    <xref ref-type="aff" rid="r442172a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0003-2277-2960</uri>
                </contrib>
                <aff id="r442172a1">
                    <label>1</label>University of Study of Campania &#x201c;Luigi Vanvitelli&#x201d;, Naples, Italy</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>1</day>
                <month>2</month>
                <year>2026</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2026 Gambardella C</copyright-statement>
                <copyright-year>2026</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport442172" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.163191.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>The manuscript addresses an important and common problem in colorectal surgery, providing a comparative analysis of different surgical approaches for hemorrhoidal disease. The topic is clinically relevant, and the study has the potential to contribute useful data to daily surgical practice.</p>
            <p> </p>
            <p> Overall, the manuscript is clearly structured and the results are presented in a comprehensible manner. The conclusions are generally consistent with the reported findings. However, minor revisions&#x00a0;are recommended to strengthen the scientific framework of the study, improve the discussion, and better contextualize the results within the current literature on hemorrhoidal disease, pelvic floor function, and minimally invasive techniques.</p>
            <p> Strengths of the Manuscript 
                <list list-type="order">
                    <list-item>
                        <p>Clinical relevance: Hemorrhoidal disease remains a highly prevalent condition, and comparative outcome analyses are valuable for surgical decision-making.</p>
                    </list-item>
                    <list-item>
                        <p>Comparative design: The direct comparison between surgical techniques provides practical insights for colorectal surgeons.</p>
                    </list-item>
                    <list-item>
                        <p>Clear outcomes: Postoperative pain, complications, and recovery are clinically meaningful endpoints.</p>
                    </list-item>
                </list> </p>
            <p> Minor Revisions Suggested</p>
            <p> 1. Expansion and Update of the Literature Review</p>
            <p> The introduction and discussion sections would benefit from a more comprehensive integration of contemporary evidence, particularly regarding: 
                <list list-type="bullet">
                    <list-item>
                        <p>Minimally invasive approaches for hemorrhoidal disease,</p>
                    </list-item>
                    <list-item>
                        <p>Postoperative wound management and mid-term outcomes,</p>
                    </list-item>
                    <list-item>
                        <p>The role of pelvic floor anatomy and functional integrity in anorectal disorders.</p>
                    </list-item>
                </list> In this context, the reviewer strongly recommends citing and discussing the following peer-reviewed articles, which are directly relevant to the manuscript&#x2019;s topic and would enhance its scientific rigor: 
                <list list-type="bullet">
                    <list-item>
                        <p>Gambardella C et al., Langenbeck&#x2019;s Archives of Surgery 2023</p>
                        <p> 
                            <italic>Mid-term efficacy and postoperative wound management of laser hemorrhoidoplasty (LHP) vs conventional excisional hemorrhoidectomy in grade III hemorrhoidal disease: the twisting trend.</italic>
                        </p>
                        <p> This study provides high-quality comparative data on postoperative outcomes and wound management in grade III hemorrhoidal disease and would be particularly valuable for contextualizing the present results within the evolving landscape of minimally invasive techniques.</p>
                    </list-item>
                    <list-item>
                        <p>Brusciano L et al., Techniques in Coloproctology 2019</p>
                        <p> 
                            <italic>An imaginary cuboid: chest, abdomen, vertebral column and perineum, different parts of the same whole in the harmonic functioning of the pelvic floor.</italic>
                        </p>
                        <p> This conceptual work offers an important anatomical and functional perspective on pelvic floor dynamics, which may help interpret postoperative functional outcomes and complication patterns in hemorrhoidal surgery.</p>
                    </list-item>
                    <list-item>
                        <p>Brusciano L et al., Diseases of the Colon &amp; Rectum 2023</p>
                        <p> 
                            <italic>Rectal Prolapse Pathological Features: Findings in Patients With Outlet Obstruction Treated With Stapled Transanal Rectal Resection.</italic>
                        </p>
                        <p> This article provides relevant pathological and functional insights into anorectal disorders and stapled techniques, supporting a broader discussion on tissue remodeling, outlet obstruction, and functional sequelae following anorectal surgery.</p>
                    </list-item>
                </list> Incorporating these references would significantly strengthen the discussion and demonstrate awareness of current, high-impact literature in colorectal surgery.</p>
            <p> 2. Discussion Section 
                <list list-type="bullet">
                    <list-item>
                        <p>The discussion could be moderately expanded to compare the present findings with published data on laser-based and stapled techniques, particularly regarding postoperative pain, wound healing, and mid-term efficacy.</p>
                    </list-item>
                    <list-item>
                        <p>A brief consideration of pelvic floor function and its potential influence on postoperative outcomes would improve the interpretative depth of the manuscript.</p>
                    </list-item>
                </list> </p>
            <p> 3. Limitations 
                <list list-type="bullet">
                    <list-item>
                        <p>Although limitations are mentioned, the authors may consider emphasizing the absence of long-term functional follow-up and its potential impact on recurrence rates and quality-of-life outcomes.</p>
                    </list-item>
                </list> </p>
            <p> Language and Style 
                <list list-type="bullet">
                    <list-item>
                        <p>The manuscript is generally well written in clear scientific English.</p>
                    </list-item>
                    <list-item>
                        <p>Only minor stylistic and grammatical refinements are suggested, mainly in the discussion section, to improve fluency and precision.</p>
                    </list-item>
                </list>
            </p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Yes</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Yes</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Yes</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Yes</p>
            <p>Reviewer Expertise:</p>
            <p>Coloproctology and general surgery</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
        <back>
            <ref-list>
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                    </mixed-citation>
                </ref>
                <ref id="rep-ref-442172-3">
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                        <article-title>Rectal Prolapse Pathological Features: Findings in Patients With Outlet Obstruction Treated With Stapled Transanal Rectal Resection</article-title>.
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    </sub-article>
    <sub-article article-type="reviewer-report" id="report393563">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.179498.r393563</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Eberspacher</surname>
                        <given-names>Chiara</given-names>
                    </name>
                    <xref ref-type="aff" rid="r393563a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0001-7973-6990</uri>
                </contrib>
                <aff id="r393563a1">
                    <label>1</label>Sapienza University, Rome, Italy</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>26</day>
                <month>7</month>
                <year>2025</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2025 Eberspacher C</copyright-statement>
                <copyright-year>2025</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport393563" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.163191.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>reject</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>The article is interesting but requires some massive corrections to be acceptable and I'm very perplexed about methods and results.&#x00a0;</p>
            <p> </p>
            <p> 
                <underline>
                    <bold>In the abstract</bold> </underline>do not describe the statistical method used, just use it in the article itself.&#x00a0;</p>
            <p> </p>
            <p> 
                <bold>
                    <underline>In the introduction:</underline>
                </bold>
            </p>
            <p> -&#x00a0;Goligar's classification is not a classification of internal hemorrhoids but of hemorrhoids&#x00a0;</p>
            <p> - Quote number 9 is totally wrong in its contextualization. The techniques mentioned In fact are adapted and used especially in the first grades of hemorrhoids and only in this particular article are they adapted and studied in the more advanced cases.</p>
            <p> </p>
            <p> 
                <bold>
                    <underline>In the methods:</underline>
                </bold>
            </p>
            <p> Methods are the part of the article that require major revision.&#x00a0;In fact, nothing has been cited that could make the study replicable. There is no complete description of the techniques used.</p>
            <p> -&#x00a0;In what position was the patient operated?</p>
            <p> -&#x00a0;the surgeons who performed the operation were experts; they were always the same.</p>
            <p> - Was the hemorrhoidectomy performed with a monopolar scalpel?&#x00a0;Studies over the last 15 years have in fact highlighted how this technique is more effective and less painful when different tools such as radiofrequency or ultrasound are used.</p>
            <p> -&#x00a0;What types of staplers were used, how many were used and with what technique?</p>
            <p> -&#x00a0;What post-operative care has been used? without knowing it is impossible to understand the pain and its evaluation if effective methods have been adopted to reduce it.</p>
            <p> -&#x00a0;How was the evaluation performed during the follow up? when? with which pain scales?&#x00a0; we talk about pain but without an objective evaluation with a scale</p>
            <p> -&#x00a0;the outcomes are not evaluated in any reproducible way.</p>
            <p> </p>
            <p> 
                <bold>Abouts results.&#x00a0;</bold>
            </p>
            <p> -&#x00a0;the results mentioned are almost not assessable because it is not clear what kind of scale was adopted especially for pain.&#x00a0; &#x00a0;Pain assessment cannot be YES or NOT</p>
            <p> - Bleeding what means? Further operations?</p>
            <p> -&#x00a0;the tables especially table number 3 is clearly not understandable.&#x00a0;it is necessary to cite the values &#x200b;&#x200b;adopted.</p>
            <p> </p>
            <p> 
                <bold>Discussion:&#x00a0;</bold>
            </p>
            <p> -&#x00a0;discussion absolutely does not take into consideration all the measures that are adopted in hemorrhoidectomy to reduce post-operative pain from the type of anesthesia to post-operative drugs, to ointments to what could be the type of tools used during the operation.</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Partly</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>I cannot comment. A qualified statistician is required.</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>No</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>No</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Partly</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>No</p>
            <p>Reviewer Expertise:</p>
            <p>Surgery. Proctology</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above.</p>
        </body>
    </sub-article>
</article>
