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    <front>
        <journal-meta>
            <journal-id journal-id-type="pmc">F1000Research</journal-id>
            <journal-title-group>
                <journal-title>F1000Research</journal-title>
            </journal-title-group>
            <issn pub-type="epub">2046-1402</issn>
            <publisher>
                <publisher-name>F1000 Research Limited</publisher-name>
                <publisher-loc>London, UK</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="doi">10.12688/f1000research.163729.1</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Study Protocol</subject>
                </subj-group>
                <subj-group>
                    <subject>Articles</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Autoimmune Patient Health Through a Flourishing Framework: Protocol Scoping Review</article-title>
                <fn-group content-type="pub-status">
                    <fn>
                        <p>[version 1; peer review: awaiting peer review]</p>
                    </fn>
                </fn-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Pasca Rina</surname>
                        <given-names>Amherstia</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Funding Acquisition</role>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0003-2422-1708</uri>
                    <xref ref-type="aff" rid="a1">1</xref>
                    <xref ref-type="aff" rid="a2">2</xref>
                </contrib>
                <contrib contrib-type="author" corresp="yes">
                    <name>
                        <surname>Surjaningrum</surname>
                        <given-names>Endang R.</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Project Administration</role>
                    <role content-type="http://credit.niso.org/">Resources</role>
                    <role content-type="http://credit.niso.org/">Software</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="corresp" rid="c1">a</xref>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Kesuma Dewi</surname>
                        <given-names>Triana</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Project Administration</role>
                    <role content-type="http://credit.niso.org/">Resources</role>
                    <role content-type="http://credit.niso.org/">Software</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <aff id="a1">
                    <label>1</label>Doctoral Psychology, Airlangga University, Surabaya, East Java, 60115, Indonesia</aff>
                <aff id="a2">
                    <label>2</label>Psychology, Universitas 17 Agustus, Indonesia, Indonesia</aff>
            </contrib-group>
            <author-notes>
                <corresp id="c1">
                    <label>a</label>
                    <email xlink:href="mailto:Endang.surjaningrum@psikologi.unair.ac.id">Endang.surjaningrum@psikologi.unair.ac.id</email>
                </corresp>
                <fn fn-type="conflict">
                    <p>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>4</day>
                <month>7</month>
                <year>2025</year>
            </pub-date>
            <pub-date pub-type="collection">
                <year>2025</year>
            </pub-date>
            <volume>14</volume>
            <elocation-id>656</elocation-id>
            <history>
                <date date-type="accepted">
                    <day>16</day>
                    <month>6</month>
                    <year>2025</year>
                </date>
            </history>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2025 Pasca Rina A et al.</copyright-statement>
                <copyright-year>2025</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <self-uri content-type="pdf" xlink:href="https://f1000research.com/articles/14-656/pdf"/>
            <abstract>
                <sec>
                    <title>Introduction</title>
                    <p>Autoimmune diseases often require long-term management and significantly affect patients&#x2019; physical and mental health. Conventional management strategies emphasize disease control and symptom relief, notwithstanding, the integration of positive health models such as the flourishing framework remains underexplored.</p>
                </sec>
                <sec>
                    <title>Objective</title>
                    <p>This protocol outlines a scoping review aimed to map and analyze how the flourishing framework has been applied in research and practice in autoimmune context.</p>
                </sec>
                <sec>
                    <title>Methods</title>
                    <p>Following the Joanna Briggs Institute (JBI) methodology for scoping reviews and the PRISMA-ScR guidelines, we will systematically search across multiple databases, including MEDLINE, Scopus, CINAHL, and PsycINFO. Studies will be screened using predetermined eligibility criteria. Data will be extracted and charted using a standardize form and will be analyzed narratively by presenting key characteristics and thematic trends.</p>
                </sec>
                <sec>
                    <title>Conclusion</title>
                    <p>The findings from this scoping review will provide a foundational insight into how flourishing is conceptualized, measured, and applied in the context of autoimmune disease. Thus, informing future research and integrative care models.</p>
                </sec>
            </abstract>
            <kwd-group kwd-group-type="author">
                <kwd>Flourishing</kwd>
                <kwd>Autoimmune</kwd>
                <kwd>Autoimmune Patients</kwd>
                <kwd>Mental Health</kwd>
                <kwd>Scoping Review</kwd>
            </kwd-group>
            <funding-group>
                <award-group id="fund-1">
                    <funding-source>Indonesia Endowment Fund for Education</funding-source>
                </award-group>
                <funding-statement>This work was supported by the Indonesia Endowment Fund for Education (Lembaga Pengelola Dana Pendidikan/LPDP), Ministry of Finance of the Republic of Indonesia.</funding-statement>
                <funding-statement>
                    <italic>The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</italic>
                </funding-statement>
            </funding-group>
        </article-meta>
    </front>
    <body>
        <sec id="sec5" sec-type="intro">
            <title>Introduction</title>
            <p>Autoimmune diseases affect over 50 million people in the United States, with more than 150 types of disease recognized.
                <sup>
                    <xref ref-type="bibr" rid="ref1">1</xref>
                </sup> A population-based study conducted in Sardinia, Italy, found that rheumatoid arthritis, systemic lupus erythematosus, and autoimmune thyroiditis were among the most common types. These diseases predominantly impact individuals in their productive age (&gt;18 years), especially women, due to hormonal differences, including higher estrogen levels.
                <sup>
                    <xref ref-type="bibr" rid="ref2">2</xref>
                </sup>
            </p>
            <p>Autoimmune disease also remains as major public health concern in Indonesia. The prevalence of type 1 diabetes &#x2013;an autoimmune condition&#x2013; in this country was reported at 41,000 cases in 2022,
                <sup>
                    <xref ref-type="bibr" rid="ref3">3</xref>
                </sup> marking as the highest in Southeast Asia. Additionally, rheumatoid arthritis affects 7.3% of the population with 8.5% cases are women and 6.1% are men.
                <sup>
                    <xref ref-type="bibr" rid="ref4">4</xref>
                </sup> The Center for Data and Information in Indonesia indicated that lupus cases in Indonesia increased by 2,166 in 2016, with the death rate increasing by 550 cases. This number is suspected to be even higher, as there is no national registry for Lupus patients.
                <sup>
                    <xref ref-type="bibr" rid="ref5">5</xref>
                </sup>
            </p>
            <p>Autoimmune diseases are characterized by a malfunction of the immune system, resulting in the production of autoantibodies that attack healthy tissues and cause inflammation.
                <sup>
                    <xref ref-type="bibr" rid="ref6">6</xref>
                </sup> Autoimmune diseases affect various organs and systems in the body, causing various susceptibility conditions, both physically and psychologically. Specifically, autoimmune disease associated with behavior and physiological problems, i.e., higher burnout and lower work engagement; cardiovascular risk and systolic blood pressure.
                <sup>
                    <xref ref-type="bibr" rid="ref7">7</xref>,
                    <xref ref-type="bibr" rid="ref8">8</xref>
                </sup> Additionally, study on Lupus patients indicated that the diseases associated with reduced appetite, difficulty sleeping, frequent illness, and fatigue quickly when autoimmune symptoms appeared.
                <sup>
                    <xref ref-type="bibr" rid="ref9">9</xref>
                </sup> There is a 20% risk of miscarriage in pregnant women with autoimmune diseases,
                <sup>
                    <xref ref-type="bibr" rid="ref10">10</xref>
                </sup> and patients with comorbid depression have a 19% higher mortality rate and are characterized by less adherence to treatment.
                <sup>
                    <xref ref-type="bibr" rid="ref11">11</xref>
                </sup> Previous studies indicated that psychological conditions were also compromised during the disease development: The patients&#x2019; perception, behavior, and overall wellbeing were affected, it even associated with psychosis
                <sup>
                    <xref ref-type="bibr" rid="ref12">12</xref>
                </sup> or eating disorder,
                <sup>
                    <xref ref-type="bibr" rid="ref13">13</xref>
                </sup> thus, promote negative emotions (i.e., worry and sadness
                <sup>
                    <xref ref-type="bibr" rid="ref14">14</xref>
                </sup>). A study among pregnant women with autoimmune showed an increase risk of schizophrenia in their offspring when blood inflammation occurs during pregnancy.
                <sup>
                    <xref ref-type="bibr" rid="ref15">15</xref>
                </sup>
            </p>
            <p>The existing literature draws upon closely related concept such as wellbeing, happiness, and mental health. However, limited study specifically focusing on flourishing among autoimmune population. A study conducted by Kayes
                <sup>
                    <xref ref-type="bibr" rid="ref16">16</xref>
                </sup> among 3,032 people with chronic diseases identified that only minor sample (n = 1%) were flourishing and 
                <italic toggle="yes">languishing</italic> &#x2013; the opposite of flourishing &#x2013; is linked to higher susceptibility to chronic diseases. Previous studies on flourishing conducted commonly drawn within healthy population (see
                <sup>
                    <xref ref-type="bibr" rid="ref17">17</xref>,
                    <xref ref-type="bibr" rid="ref18">18</xref>
                </sup>). A study on flourishing in Indonesia was conducted by Irsyadiyah et al.
                <sup>
                    <xref ref-type="bibr" rid="ref19">19</xref>
                </sup> on the effectivity of positive psychotherapy intervention using positive psychotherapy indicated that Lupus patients reported improvement on flourishing indicator after the intervention.</p>
            <p>Given the limited empirical exploration of flourishing in the context of autoimmune, this scoping review aims to mapping the existing literature and identifying concept of flourishing as well as identify the research gaps that may beneficial to inform future empirical studies and interventions. Therefore, the objectives of this scoping review were threefold:
                <list list-type="order">
                    <list-item>
                        <label>1.</label>
                        <p>To provide an overview of flourishing among autoimmune patients.</p>
                    </list-item>
                    <list-item>
                        <label>2.</label>
                        <p>To summarize and clarify terminology related to the impact of autoimmune diseases on patients.</p>
                    </list-item>
                    <list-item>
                        <label>3.</label>
                        <p>To identify knowledge gaps and suggest directions for future research.</p>
                    </list-item>
                </list>
            </p>
        </sec>
        <sec id="sec6">
            <title>Methods and analysis protocol</title>
            <p>This scoping review protocol methods and analyses followed the five-stages framework developed by Arksey and O&#x2019;Malley.
                <sup>
                    <xref ref-type="bibr" rid="ref20">20</xref>
                </sup> This protocol of systematic review did not use informed consent because it&#x2019;s not involving humans or animals including children. This research is part of a bigger project aimed at developing a framework of flourishing in the autoimmune context. Ethical clearance for this project was obtained from Ethics Committee of the Faculty of Psychology, Airlangga University, Indonesia number No.762/B/UN3.FPSI/III/TA.00.03/2025.</p>
            <sec id="sec7">
                <title>Stage 1: Identifying research questions (PCC)</title>
                <p>The research questions were identified before conducting a scoping review of protocol elements according to the PCC structure. The aim of this study is to identify elements and factors of flourishing that influence the health of patients with autoimmune diseases.</p>
            </sec>
            <sec id="sec8">
                <title>Population</title>
                <p>Autoimmune disease can affect any individuals in any age range. However, autoimmune diseases commonly affect individuals in productive age (i.e., 18-64 years; see 1). Therefore, the study population will be specified in this age group.</p>
            </sec>
            <sec id="sec9">
                <title>Concept</title>
                <p>Autoimmune diseases can be exacerbated under excessive stress.
                    <sup>
                        <xref ref-type="bibr" rid="ref21">21</xref>
                    </sup> Therefore, disease management of autoimmune disease involving the effort to maintain psychological stability. Flourishing is a potential strategy to achieve this goal of psychological stability. Flourishing defined as the relative attainment of a state in which all aspects of an individual&#x2019;s life (both internal and external) are functioning well.
                    <sup>
                        <xref ref-type="bibr" rid="ref22">22</xref>
                    </sup> In this study, flourishing is conceptualized as protective factors of chronic diseases management.
                    <sup>
                        <xref ref-type="bibr" rid="ref23">23</xref>
                    </sup>
                </p>
            </sec>
            <sec id="sec10">
                <title>Context</title>
                <p>The search was focus on studies related to individual with autoimmune disease and having history of mental health symptom. This focus reflects the vulnerability of individual with autoimmune to excessive stress and its role on symptom exacerbation.
                    <sup>
                        <xref ref-type="bibr" rid="ref21">21</xref>
                    </sup>
                </p>
                <p>Based on above mentioned rationale, this scoping review research questions are:
                    <list list-type="order">
                        <list-item>
                            <label>1.</label>
                            <p>What is the overview of flourishing in autoimmune individuals?</p>
                        </list-item>
                        <list-item>
                            <label>2.</label>
                            <p>What flourishing frameworks are typically found in the context of autoimmune?</p>
                        </list-item>
                        <list-item>
                            <label>3.</label>
                            <p>What knowledge gaps exist regarding flourishing models in individuals with autoimmune conditions?</p>
                        </list-item>
                    </list>
                </p>
            </sec>
            <sec id="sec11">
                <title>Stage 2: Identify relevant studies</title>
                <p>A systematic searching strategy of relevant studies will be developed in consultation with experts in this field and following the guidelines provided by librarians. The search for articles was conducted on seven databases: ProQuest, Web of Science, ScienceDirect, Taylor &amp; Francis, EBSCO, Sage Journals, and SpringerLink. We aimed to broaden the search strategy to capture as many as studies as possible by including term (flourishing OR well#being OR Happiness) AND (autoimmune) as the keywords, as these terms are conceptually related and grounded in the similar theoretical frameworks. Manual search was also conducted by tracing citation networks and publication years using research mapping tools. Additionally, gray literatures were included to enrich the comprehensiveness of the review. To guide the screening of titles and abstract, inclusion and exclusion criteria were defined at this stage. Further, article duplication was also screened prior to final selection.</p>
            </sec>
            <sec id="sec12">
                <title>Stage 3: Study selection</title>
                <p>Two independent reviewers will screen titles and abstract based on inclusion and exclusion criteria as it can see on the 
                    <xref ref-type="table" rid="T1">
Table 1</xref>. Studies examining broadly on health without specifically mentioning flourishing will be excluded. Studies combining age categories will be included if involving participants age 18-64.</p>
                <table-wrap id="T1" orientation="portrait" position="float">
                    <label>
Table 1. </label>
                    <caption>
                        <title>Inclusion and exclusion criteria.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Inclusion criteria</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">
Exclusion criteria</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">The study involving autoimmune patients aged 18-64 years</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Studies investigating Quality of Life, Life Satisfaction, and General Health Well-Being
</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">The study investigating flourishing, well-being, or happiness within positive psychology framework</td>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Published or translated into English</td>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Published from January 2018 onward</td>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
            </sec>
            <sec id="sec13">
                <title>Stage 4: Data extraction</title>
                <p>Data will be extracted from papers included in the scoping review by two independent reviewers using a modified JBI data extraction tool developed for this scoping review. The extracted data will include specific details about the population (e.g., age, diagnosis, type of autoimmune disease), methodology, models and concepts of flourishing, and key findings related to the object of review and inquiry. The draft of data extraction tool was modified and revised throughout the extraction process. Discrepancies between the reviewers will be resolved through discussion to achieve consensus or by a third-party review.</p>
            </sec>
            <sec id="sec14">
                <title>Stage 5: Reporting the results (manuscript)</title>
                <p>The scoping review results will be reported through a narrative synthesis, flow diagrams (using PRISMA), and descriptive tables. These report will reflect and summarize the study characteristics, conceptual frameworks, identified gaps, and implication for research and practice in autoimmune care context.</p>
            </sec>
        </sec>
        <sec id="sec15" sec-type="conclusion">
            <title>Conclusion</title>
            <p>This protocol provides a systematic approach to conduct a scoping review of flourishing framework among individual with autoimmune context within five stages. It outlines obvious inclusion criteria, a transparent methodology, and a rationale for the scoping review scope. The limitations include the specific age range being studied and involving studies reported or translated in English only, thus may limits the scope of the subject being studied.</p>
        </sec>
    </body>
    <back>
        <sec id="sec18" sec-type="data-availability">
            <title>Data availability</title>
            <p>No dataset was generated or analyzed during the preparation of this protocol.</p>
        </sec>
        <ack>
            <title>Acknowledgment</title>
            <p>This work was supported by the Indonesia Endowment Fund for Education (Lembaga Pengelola Dana Pendidikan/LPDP), Ministry of Finance of the Republic of Indonesia. The authors gratefully acknowledge this funding support, which enabled the publication of this journal article.</p>
            <p>We sincerely thank the Faculty of Psychology, Airangga University, for supporting this study, Dr. Rahkman Ardi for methodological consultation, and Ms. Salsabila R. K. Syaharani and Mr. M. Rizal for their assistance in developing this protocol.</p>
        </ack>
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