<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN" "http://jats.nlm.nih.gov/publishing/1.2/JATS-journalpublishing1.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="research-article" dtd-version="1.2" xml:lang="en">
    <front>
        <journal-meta>
            <journal-id journal-id-type="pmc">F1000Research</journal-id>
            <journal-title-group>
                <journal-title>F1000Research</journal-title>
            </journal-title-group>
            <issn pub-type="epub">2046-1402</issn>
            <publisher>
                <publisher-name>F1000 Research Limited</publisher-name>
                <publisher-loc>London, UK</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="doi">10.12688/f1000research.166264.1</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Research Article</subject>
                </subj-group>
                <subj-group>
                    <subject>Articles</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Assessment of Community Pharmacists&#x2019; Knowledge, Attitude, and Practice Toward Counseling Hypertensive Patients in the United Arab Emirates</article-title>
                <fn-group content-type="pub-status">
                    <fn>
                        <p>[version 1; peer review: 2 approved with reservations]</p>
                    </fn>
                </fn-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author" corresp="yes">
                    <name>
                        <surname>Menon</surname>
                        <given-names>Vineetha</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Project Administration</role>
                    <role content-type="http://credit.niso.org/">Resources</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-4431-0196</uri>
                    <xref ref-type="corresp" rid="c1">a</xref>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Gulzar Ahmed</surname>
                        <given-names>Mahin</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <xref ref-type="aff" rid="a2">2</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Myalil Lucca</surname>
                        <given-names>Jisha</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0001-9878-7443</uri>
                    <xref ref-type="aff" rid="a3">3</xref>
                </contrib>
                <aff id="a1">
                    <label>1</label>Ph.D., Assistant Professor, Department of Pharmacy Practice, College of Pharmacy, Gulf Medical University, Ajman, United Arab Emirates</aff>
                <aff id="a2">
                    <label>2</label>Pharm.D, Postgraduate Research Student, Department of Pharmacy Practice, College of Pharmacy, Gulf Medical University, Ajman, United Arab Emirates</aff>
                <aff id="a3">
                    <label>3</label>Ph.D., Assistant Professor, Department of Pharmacy Practice, College of Pharmacy, Gulf Medical University, Ajman, United Arab Emirates</aff>
            </contrib-group>
            <author-notes>
                <corresp id="c1">
                    <label>a</label>
                    <email xlink:href="mailto:dr.vineetha@gmu.ac.ae">dr.vineetha@gmu.ac.ae</email>
                </corresp>
                <fn fn-type="conflict">
                    <p>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>17</day>
                <month>7</month>
                <year>2025</year>
            </pub-date>
            <pub-date pub-type="collection">
                <year>2025</year>
            </pub-date>
            <volume>14</volume>
            <elocation-id>705</elocation-id>
            <history>
                <date date-type="accepted">
                    <day>8</day>
                    <month>7</month>
                    <year>2025</year>
                </date>
            </history>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2025 Menon V et al.</copyright-statement>
                <copyright-year>2025</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <self-uri content-type="pdf" xlink:href="https://f1000research.com/articles/14-705/pdf"/>
            <abstract>
                <sec>
                    <title>Background</title>
                    <p>Hypertension remains inadequately controlled worldwide despite the availability of effective treatments and is a major risk factor for cardiovascular diseases. Community pharmacists, due to their accessibility and expanding patient-centered roles, can play a vital part in its management through counseling and education. This study aimed to assess the knowledge, attitude, and practice of community pharmacists in the UAE regarding hypertension counseling and identify associated influencing factors.</p>
                </sec>
                <sec>
                    <title>Methods</title>
                    <p>A cross-sectional quantitative study was conducted over six months using a validated, self-administered online questionnaire. Registered or licensed community pharmacists from all seven emirates of the UAE were recruited through non-probability convenience sampling. The survey link was distributed via WhatsApp, Email, Facebook, and LinkedIn. Informed consent was obtained electronically. Knowledge was assessed using six binary-coded items; attitude and practice were measured through nine items each on five-point Likert scales. Respondents scoring equal to or above the mean were classified as having &#x201c;good knowledge,&#x201d; &#x201c;positive attitude,&#x201d; and &#x201c;good practice.&#x201d; Data were analyzed using SPSS with descriptive statistics, t-tests, ANOVA, and linear regression. Statistical significance was set at 
                        <italic toggle="yes">p</italic> &lt; 0.05.</p>
                </sec>
                <sec>
                    <title>Results</title>
                    <p>Among the 114 pharmacists included, 70% demonstrated good knowledge, 46% had a positive attitude, and 51% reported good counseling practices. Knowledge scores were significantly associated with employment type (
                        <italic toggle="yes">p</italic> = 0.0305). Attitude scores showed significant associations with gender and level of education (
                        <italic toggle="yes">p</italic> &lt; 0.05). Practice scores were significantly related to the number of patients counseled per week (
                        <italic toggle="yes">p</italic> = 0.0007). A significant positive correlation was found between attitude and practice scores (r = 0.2430, 
                        <italic toggle="yes">p</italic> = 0.0091).</p>
                </sec>
                <sec>
                    <title>Conclusions</title>
                    <p>While UAE community pharmacists showed good knowledge, there were notable gaps in attitude and practice related to hypertension counseling. Targeted interventions are warranted to optimize their role in improving hypertension management.</p>
                </sec>
            </abstract>
            <kwd-group kwd-group-type="author">
                <kwd>Community pharmacy services</kwd>
                <kwd>Hypertension</kwd>
                <kwd>Patient counseling</kwd>
                <kwd>KAP (Knowledge</kwd>
                <kwd>attitude</kwd>
                <kwd>and practice)</kwd>
                <kwd>United Arab Emirates</kwd>
            </kwd-group>
            <funding-group>
                <funding-statement>The author(s) declared that no grants were involved in supporting this work.</funding-statement>
            </funding-group>
        </article-meta>
    </front>
    <body>
        <sec id="sec5" sec-type="intro">
            <title>Introduction</title>
            <p>Hypertension is a major global health concern and one of the leading modifiable risk factors for cardiovascular diseases (CVDs), including heart attacks and strokes, and is also a primary cause of premature death worldwide.
                <sup>
                    <xref ref-type="bibr" rid="ref1">1</xref>,
                    <xref ref-type="bibr" rid="ref2">2</xref>
                </sup> As of 2023, approximately 1.28 billion adults aged 30-79 are affected by hypertension.
                <sup>
                    <xref ref-type="bibr" rid="ref2">2</xref>
                </sup> Despite the availability of effective treatment options, blood pressure control remains suboptimal, particularly in low- and middle-income countries.
                <sup>
                    <xref ref-type="bibr" rid="ref1">1</xref>
                </sup> Only about 54% of individuals with hypertension are globally diagnosed, 42% receive treatment, and just 21% achieve adequate blood pressure control.
                <sup>
                    <xref ref-type="bibr" rid="ref3">3</xref>
                </sup> In the United Arab Emirates (UAE), the burden of hypertension is similarly significant.
                <sup>
                    <xref ref-type="bibr" rid="ref4">4</xref>
                </sup> A systematic review and meta-analysis of 15 cross-sectional studies involving 139,907 adults reported a pooled prevalence of 31%, with only 38% of affected individuals achieving blood pressure control.
                <sup>
                    <xref ref-type="bibr" rid="ref5">5</xref>
                </sup> These figures underscore the urgent need for effective prevention, management, and patient education strategies, both globally and within the UAE.</p>
            <p>Effective management of hypertension is critical for slowing disease progression and improving public health outcomes. A key component of this management involves enhancing patients&#x2019; awareness and understanding of their condition, which has been shown to improve treatment adherence and support better blood pressure control.
                <sup>
                    <xref ref-type="bibr" rid="ref1">1</xref>
                </sup> Given their accessibility, extended hours, and frequent interactions with the public, community pharmacists are ideally positioned to provide this support through patient counseling, medication review, and lifestyle advice. The transition from product-centered to patient-centered care has further expanded the role of community pharmacists in hypertension management.
                <sup>
                    <xref ref-type="bibr" rid="ref1">1</xref>,
                    <xref ref-type="bibr" rid="ref6">6</xref>
                </sup> In the UAE, community pharmacists interact directly with nearly 90% of the population each year, including individuals at high risk for CVDs. With over 2,500 licensed pharmacies operating an average of 13 hours daily, pharmacists are among the most accessible healthcare providers, positioning them as ideal partners in public health initiatives aimed at preventing and managing CVDs.
                <sup>
                    <xref ref-type="bibr" rid="ref7">7</xref>
                </sup> By helping patients understand their medical conditions, community pharmacists can promote healthier behaviors, improve clinical outcomes, and enhance medication adherence.
                <sup>
                    <xref ref-type="bibr" rid="ref1">1</xref>
                </sup> Evidence from various countries supports the effectiveness of pharmacist-led interventions, particularly those involving patient education and counseling, in enhancing hypertension control.
                <sup>
                    <xref ref-type="bibr" rid="ref8">8</xref>&#x2013;
                    <xref ref-type="bibr" rid="ref12">12</xref>
                </sup>
            </p>
            <p>Understanding the knowledge, attitude, and practice (KAP) of community pharmacists is essential for identifying gaps in education and training, optimizing their role in hypertension management, and improving the quality of pharmaceutical services in community settings.
                <sup>
                    <xref ref-type="bibr" rid="ref4">4</xref>
                </sup> While few international studies have examined the KAP of community pharmacists in relation to hypertension counseling,
                <sup>
                    <xref ref-type="bibr" rid="ref1">1</xref>,
                    <xref ref-type="bibr" rid="ref13">13</xref>
                </sup> to date, there are no published studies from the UAE addressing this subject.
                <sup>
                    <xref ref-type="bibr" rid="ref4">4</xref>,
                    <xref ref-type="bibr" rid="ref17">17</xref>
                </sup> This study aimed to assess the KAP of community pharmacists across the UAE with regard to counseling hypertensive patients, and to explore the factors influencing these domains.</p>
        </sec>
        <sec id="sec6" sec-type="methods">
            <title>Methods</title>
            <sec id="sec7">
                <title>Study design and participants</title>
                <p>A cross-sectional, quantitative study was conducted using a self-administered online questionnaire to assess the KAP of community pharmacists toward hypertension counseling across all seven emirates of the UAE: Abu Dhabi, Dubai, Sharjah, Ajman, Ras Al Khaimah, Umm Al Quwain, and Fujairah. The study was carried out over a six-month period.</p>
                <p>
The sampling frame specifically targeted registered or licensed community pharmacists practicing in both private and government sectors who held at least a bachelor&#x2019;s degree in pharmacy, had a minimum of three months&#x2019; experience in community pharmacy practice, and were actively involved in providing pharmaceutical care to hypertensive patients. Eligible participants were expected to have experience in dispensing antihypertensive medications and counseling patients on hypertension management. Pharmacists working in hospitals, academia, the pharmaceutical industry, or marketing roles were excluded. Trainee pharmacists, those on probation, and individuals unwilling to participate were also excluded.</p>
                <p>The minimum sample size was estimated at 334 participants using the Raosoft sample size calculator. This estimate was based on an assumed population of 2,500 licensed community pharmacies in the UAE,
                    <sup>
                        <xref ref-type="bibr" rid="ref7">7</xref>
                    </sup> with the assumption of one pharmacist per pharmacy. The sample size was calculated using a 95% confidence level, a 5% margin of error, and an anticipated response distribution of 50%. Despite efforts to meet the target, only 200 community pharmacists consented to participate in the study. A non-probability convenience sampling method was employed for participant recruitment.</p>
            </sec>
            <sec id="sec8">
                <title>Variables and study instrument</title>
                <p>Initial development of the self-administered questionnaire was informed by a review of existing literature on hypertension counseling practices, with modifications made to tailor the content to the UAE community pharmacy context. These adaptations involved contextualizing terminology and refining questions to align with the specific aims and objectives of the current study.</p>
                <p>
Following the initial development of the questionnaire, content validation was undertaken to ensure item relevance and comprehensive coverage of the study constructs. A panel of five academic experts in clinical pharmacy, with specific expertise in community pharmacy research, independently evaluated each item for relevance, clarity, and alignment with the study objectives. Based on their feedback, minor revisions were made to improve wording and contextual appropriateness. Content validity was assessed quantitatively using Lawshe&#x2019;s method, in which the Content Validity Ratio (CVR) for each item is calculated. Items with a CVR greater than 0.78 were retained, while those falling below this threshold were excluded. All items in the final questionnaire achieved CVR values above 0.78, indicating acceptable item-level content validity. The overall Content Validity Index (CVI), calculated as the average of CVRs across all retained items, was 0.852, demonstrating acceptable content validity for the instrument. Face validity was subsequently assessed by five practicing community pharmacists representative of the target population. These pharmacists reviewed the questionnaire for clarity, readability, and perceived relevance to routine pharmacy practice. Their feedback prompted minor linguistic and formatting refinements to improve comprehension without altering the substantive content of the items.
</p>
                <p>Reliability testing was conducted through a pilot study involving ten community pharmacists who met the inclusion criteria but were excluded from the final analysis. This pilot phase served to assess the internal consistency of the questionnaire and to verify the acceptability of the item length and structure. Reliability was evaluated using Cronbach&#x2019;s alpha, which yielded a value of 0.77 for the overall instrument, indicating acceptable internal consistency. Domain-specific reliability coefficients were also computed, with alpha values of 0.80 for the knowledge domain, 0.85 for attitudes, and 0.87 for practice. These values exceed the commonly accepted threshold of 0.70, confirming acceptable internal consistency across all sections.
</p>
                <p>The finalized self-administered questionnaire consisted of 34 items and included a combination of open-ended responses and structured multiple-choice options. The instrument was organized into four distinct sections, each designed to capture a specific domain relevant to the study objectives. Section 1 focused on sociodemographic and professional characteristics, including age, gender, educational qualifications, type of employment, place of employment, total work experience, and the average number of patients seen and counseled per week. This section also included items assessing prior participation in training or educational programs related to hypertension management, familiarity with current clinical practice guidelines, and knowledge of proper techniques for using blood pressure monitoring devices. Section 2 assessed community pharmacists&#x2019; perceived knowledge regarding hypertension counseling, while Section 3 explored their attitudes toward providing such counseling. Section 4 evaluated actual practice behaviors related to hypertension counseling in the community pharmacy setting.
</p>
                <p>
Community pharmacists&#x2019; perceived knowledge regarding hypertension counseling was assessed using six items designed to evaluate key domains: (1) diagnostic thresholds for hypertension, (2) awareness of modifiable risk factors, (3) recognition of major complications associated with uncontrolled hypertension, (4) understanding of treatment initiation criteria for antihypertensive therapy, (5) familiarity with clinical practice guidelines (e.g., JNC 8) for first-line medications, and (6) the importance of routine blood pressure monitoring. A three-point scoring scale was employed, with response options coded as 1 for &#x201c;true,&#x201d; and 0 for both &#x201c;false&#x201d; and &#x201c;I don&#x2019;t know.&#x201d; The total possible knowledge score ranged from 0 to 6. Cumulative mean scores were calculated, and respondents scoring greater than or equal to the mean were categorized as having &#x201c;good knowledge,&#x201d; while those scoring below the mean were classified as having &#x201c;poor knowledge.
</p>
                <p>The attitude of pharmacists toward hypertension counseling was measured through nine items capturing their perceptions of professional responsibility and confidence in providing patient-centered care. Specific areas included: (1) belief in the role of pharmacists in counseling on antihypertensive medications, (2) acknowledgment of the need for integrating counseling into routine pharmacy practice, (3) recognition of its value in enhancing the patient-pharmacist relationship, (4) understanding of its contribution to informed patient decisions, (5) its role in promoting medication adherence, (6) recognition that effective counseling requires advanced knowledge and skill, (7) self-perceived competence in delivering counseling, (8) confidence in counseling hypertensive patients, and (9) willingness to seek out information to address patient concerns. A five-point Likert scale was used, ranging from 1 (strongly disagree) to 5 (strongly agree), yielding a total attitude score ranging from 9 to 45. Mean scores were computed, and participants scoring equal to or above the mean were considered to have a &#x201c;positive attitude,&#x201d; while those scoring below the mean were categorized as having a &#x201c;negative attitude.&#x201d;</p>
                <p>The practice domain was evaluated using nine items assessing the frequency of counseling behaviors. These included: (1) how often pharmacists counsel patients when dispensing antihypertensive prescriptions, (2) the frequency with which they update their knowledge on hypertension management, (3) duration of counseling sessions exceeding five minutes, (4) counseling on correct medication use, (5) provision of information about potential side effects, (6) assessment of drug interactions, (7) emphasis on medication adherence, (8) inquiry about patients&#x2019; blood pressure readings and advising on follow-up care, and (9) consideration of patients&#x2019; personality and behavior when tailoring counseling approaches. Responses were rated on a five-point Likert scale from 1 (never) to 5 (always), resulting in a total practice score ranging from 9 to 45. Based on the calculated mean scores, respondents were classified as demonstrating &#x201c;good practice&#x201d; if their scores were equal to or above the mean, and &#x201c;poor practice&#x201d; if they scored below the mean.</p>
            </sec>
            <sec id="sec9">
                <title>Data collection</title>
                <p>The finalized questionnaire was hosted on the Google Forms platform and administered in English. The survey link was disseminated to the target population of community pharmacists through multiple digital channels, including WhatsApp, Email, Facebook, and LinkedIn. To enhance response rates, reminder messages were sent biweekly to individual contacts through all channels, while additional reminder announcements were posted in relevant Facebook and LinkedIn groups. A maximum of three individual reminders was issued to each participant, and a limit of three reminder announcements was applied to postings in each group. Prior to accessing the questionnaire, participants were presented with an electronic informed consent page outlining the study&#x2019;s objectives, its relevance to pharmacy practice, and the anticipated benefits to patient care and the broader healthcare sector. Participation was entirely voluntary, and respondents were required to provide explicit electronic consent by selecting the &#x201c;I agree&#x201d; option before proceeding to the survey.</p>
            </sec>
            <sec id="sec10">
                <title>Data analysis</title>
                <p>Data from the online questionnaire was exported into Microsoft Excel and subsequently prepared for statistical analysis. The dataset was cleaned, coded, and analyzed using the Statistical Package for the Social Sciences (SPSS), version 26. Independent variables included the sociodemographic and professional characteristics of community pharmacists, such as age, gender, educational qualifications, type of employment, total work experience, and the average number of patients counseled per week. The dependent variables were the pharmacists&#x2019; KAP scores related to hypertension counseling. Normality of continuous variables was assessed using the Kolmogorov-Smirnov test. Descriptive statistics were used to summarize the data: categorical variables were reported as frequencies and percentages, while continuous variables were expressed as means and standard deviations. To compare mean KAP scores across variables, an initial bivariate analysis was performed using the unpaired Student&#x2019;s t-test for comparisons involving continuous and dichotomous variables, and one-way ANOVA for comparisons across three or more groups. In addition, simple linear regression was conducted to explore the individual relationships between independent variables and each KAP domain score. Variables with a 
                    <italic toggle="yes">p</italic>-value less than 0.25 in the simple regression analysis were included in the multivariable models to control for potential confounders. Stepwise multiple linear regression analyses were performed, with each KAP score used as the dependent variable in separate models. A 
                    <italic toggle="yes">p</italic>-value &lt; 0.05 was considered statistically significant.</p>
            </sec>
        </sec>
        <sec id="sec11" sec-type="results">
            <title>Results</title>
            <p>Although the survey link was accessed by 200 community pharmacists across all dissemination channels, only 120 participants completed the questionnaire and provided electronic consent, yielding a response rate of 60.0%. Among those who declined participation or did not complete the survey, lack of time was commonly mentioned in informal communications. Among the 120 respondents, six were excluded due to ineligibility or incomplete survey responses. Therefore, a total of 114 participants were included in the final data analysis. The recruitment and response flow are summarized in 
                <xref ref-type="fig" rid="f1">Figure 1</xref>.</p>
            <sec id="sec12">
                <title>Demographic characteristics</title>
                <p>Demographic details of the recruited participants are summarized in 
                    <xref ref-type="table" rid="T1">
Table 1</xref>. The mean age of the community pharmacists was 34.64 &#x00b1; 8.44 years, with 52% being under 35 years of age. A slight majority (53%) of respondents were male, while 47% were female. Most participants (68%) had more than five years of work experience, with an average of 8.73 &#x00b1; 6.51 years. Regarding education, 58% held a bachelor&#x2019;s degree. In terms of employment, the majority (60%) were employed in the Northern Emirates, and 86% were working full-time. On average, participants reported seeing approximately 161 patients and counseling 91 patients per week.</p>
                <fig fig-type="figure" id="f1" orientation="portrait" position="float">
                    <label>
Figure 1. </label>
                    <caption>
                        <title>Flowchart of questionnaire distribution and participant recruitment.</title>
                        <p>Out of 200 survey links accessed, 120 completed responses were received. Of these, 6 were excluded due to incomplete data, resulting in a final sample of 114 participants included in the data analysis. Non-response accounted for 80 individuals.</p>
                    </caption>
                    <graphic id="gr1" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/183228/11a187d7-0af8-43ab-a716-caf945d70604_figure1.gif"/>
                </fig>
                <table-wrap id="T1" orientation="portrait" position="float">
                    <label>
Table 1. </label>
                    <caption>
                        <title>Demographic characteristics of community pharmacists (n = 114).</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Variables</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Categories</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">
Number (%)</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="3" valign="top">Age</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">&#x2265;35 years</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">55 (48.24)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">&lt;35 years</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">59 (51.75)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Average (in years); Mean &#x00b1; SD</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">34.64 &#x00b1; 8.44</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="2" valign="top">Gender</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Male</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">60 (52.63)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Female</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">54 (47.36)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="3" valign="top">Level of education</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Doctor of Pharmacy</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">10 (8.77)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Masters</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">25 (21.93)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Bachelors</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">79 (69.29)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="2" valign="top">Type of employment</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Full-time
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">103 (90.35)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Part-time
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">11 (9.64)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="3" valign="top">Place of employment</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Abu Dhabi</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">20 (17.54)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Dubai</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">26 (22.80)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Northern Emirates</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">68 (59.64)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="3" valign="top">Years of experience</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">&#x2265;5 years</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">78 (68.42)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">&lt;5 years</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">36 (31.57)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Average (in years); Mean &#x00b1; SD</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">8.73 &#x00b1; 6.51</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="2" rowspan="1" valign="top">Average number of patients seen in a week; Mean &#x00b1; SD</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">160.94 &#x00b1; 159.53</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="2" rowspan="1" valign="top">Average number of patients counseled in a week; Mean &#x00b1; SD</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">90.85 &#x00b1; 110.66</td>
                            </tr>
                        </tbody>
                    </table>
                    <table-wrap-foot>
                        <p>

                            <bold>Abbreviation:</bold> SD: Standard deviation.</p>
                    </table-wrap-foot>
                </table-wrap>
            </sec>
            <sec id="sec13">
                <title>Perceived knowledge, attitude, and practice</title>
                <p>As shown in 
                    <xref ref-type="fig" rid="f2">
Figure 2(a)</xref>, 84% of participants either agreed (63%) or strongly agreed (21%) that they were familiar with the current clinical practice guidelines for the management of hypertension, while only a small proportion were neutral (9%) or disagreed (7%). Similarly, 
                    <xref ref-type="fig" rid="f2">
Figure 2(b)</xref> highlights that 95% of respondents felt confident in using a blood pressure monitoring device, with 56% agreeing and 39% strongly agreeing; only a minority were neutral (3%) or disagreed (2%). Regarding training, 
                    <xref ref-type="fig" rid="f2">
Figure 2(c)</xref> shows that 78% of pharmacists reported attending and benefitting from educational programs related to hypertension management, with 55% agreeing and 23% strongly agreeing. A smaller proportion was neutral (10%), while others disagreed (11%) or strongly disagreed (1%). Overall, the findings suggest a high level of familiarity and engagement among pharmacists in the clinical and educational aspects of hypertension care.</p>
                <fig fig-type="figure" id="f2" orientation="portrait" position="float">
                    <label>
Figure 2. </label>
                    <caption>
                        <title>Insights into community pharmacists&#x2019; (a) familiarity with clinical practice guidelines, (b) familiarity with blood pressure monitoring device use, and (c) participation in training and educational programs related to hypertension management.</title>
                        <p>The figure presents the distribution of responses to three key areas assessed using a Likert scale. In (a), a majority of pharmacists agreed or strongly agreed with being familiar with current hypertension guidelines (63% and 21%, respectively). In (b), 56% agreed and 39% strongly agreed with being familiar with techniques for using blood pressure monitors, while only a small minority disagreed or were neutral. In (c), over three-quarters (78%) of respondents reported agreement or strong agreement regarding their participation in and benefit from hypertension-related educational programs. Percentages for neutral, disagree, and strongly disagree responses were comparatively lower across all three categories.</p>
                    </caption>
                    <graphic id="gr2" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/183228/11a187d7-0af8-43ab-a716-caf945d70604_figure2.gif"/>
                </fig>
                <p>Six distinct questions were used to explicitly assess community pharmacists&#x2019; self-perceived knowledge regarding hypertensive counseling. The knowledge statements and corresponding responses are presented in 
                    <xref ref-type="table" rid="T2">
Table 2</xref>. The majority of pharmacists correctly identified key diagnostic criteria for hypertension, with 85% recognizing that hypertension is diagnosed when systolic blood pressure is &#x2265;140 mmHg and/or diastolic blood pressure is &#x2265;90 mmHg (Mean: 0.85 &#x00b1; 0.35). Knowledge of modifiable risk factors was the highest among respondents, with 96% correctly identifying an unhealthy diet, physical inactivity, tobacco and alcohol use, and excess body weight as contributing factors to hypertension (Mean: 0.96 &#x00b1; 0.18). Similarly, 94% of pharmacists were aware that myocardial infarction, cerebrovascular accident, and chronic kidney disease are complications of uncontrolled hypertension (Mean: 0.93 &#x00b1; 0.24). However, knowledge was comparatively lower in the area of therapeutic recommendations. Only 70% correctly acknowledged that patients with systolic pressure &#x2265;140 mmHg and/or diastolic pressure &#x2265;90 mmHg should receive antihypertensive therapy (Mean &#x00b1; SD: 0.70 &#x00b1; 0.45). Knowledge regarding the use of thiazide diuretics as an option for initial antihypertensive therapy was lower, with only 54% answering correctly (Mean: 0.54 &#x00b1; 0.50). Most pharmacists (89%) correctly stated that routine monitoring of blood pressure is essential for assessing therapeutic response and promoting patient adherence (Mean: 0.89 &#x00b1; 0.30). The mean knowledge score among community pharmacists was 4.89 &#x00b1; 1.15. Based on the predefined cut-off, 70% of respondents demonstrated good knowledge, while 30% were categorized as having poor knowledge regarding hypertensive counseling.</p>
                <table-wrap id="T2" orientation="portrait" position="float">
                    <label>
Table 2. </label>
                    <caption>
                        <title>Community pharmacists&#x2019; self-perceived knowledge about hypertensive counseling (n = 114).</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="2" valign="top">Statements</th>
                                <th align="left" colspan="1" rowspan="2" valign="top">Min, Max</th>
                                <th align="left" colspan="2" rowspan="1" valign="top">Responses n (%)</th>
                                <th align="left" colspan="1" rowspan="2" valign="top">
Mean &#x00b1; SD</th>
                            </tr>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">
Correct</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">
Incorrect</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Hypertension is diagnosed when the systolic blood pressure is &#x2265;140 mmHg and/or the diastolic blood pressure is &#x2265;90 mmHg.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0, 1</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">97 (85.08)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">17 (14.91)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.85 &#x00b1; 0.35</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Unhealthy diet, physical inactivity, tobacco and alcohol use, and excess body weight are modifiable risk factors for hypertension.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0, 1</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">110 (96.49)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4 (3.50)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.96 &#x00b1; 0.18</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Myocardial infarction, cerebrovascular accident, and chronic kidney disease are complications of uncontrolled hypertension.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0,1</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">107 (93.85)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">7 (6.14)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.93 &#x00b1; 0.24</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">All patients with a diastolic pressure of &#x2265;90 mm Hg, a systolic pressure of &#x2265;140 mm Hg, or a combination of both should receive antihypertensive drug therapy.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0, 1</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">80 (70.17)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">34 (29.82)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.70 &#x00b1; 0.45</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">According to clinical guidelines such as JNC 8, thiazide-type diuretics (e.g., hydrochlorothiazide) are recommended as one of the first-line options for the treatment of uncomplicated hypertension.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0, 1</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">62 (54.38)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">52 (45.61)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.54 &#x00b1; 0.50</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Routine monitoring of blood pressure is essential to assess therapeutic response and promote patient adherence.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0, 1</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">102 (89.47)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">12 (10.52)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.89 &#x00b1; 0.30</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Summary</bold>
</td>
                                <td colspan="4" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Mean score &#x00b1; SD (95% CI)</td>
                                <td align="left" colspan="4" rowspan="1" valign="top">4.89 &#x00b1; 1.15 (4.68-5.10)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Range</td>
                                <td align="left" colspan="4" rowspan="1" valign="top">0-6</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Poor knowledge (&#x2264;4)</td>
                                <td align="left" colspan="4" rowspan="1" valign="top">34 (29.82)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Good knowledge (&#x2265;5)</td>
                                <td align="left" colspan="4" rowspan="1" valign="top">80 (70.17)</td>
                            </tr>
                        </tbody>
                    </table>
                    <table-wrap-foot>
                        <p>

                            <bold>Abbreviations:</bold> CI: Confidence Interval; Min, Max: Minimum and maximum score range per item; SD: Standard Deviation.</p>
                    </table-wrap-foot>
                </table-wrap>
                <p>Nine attitude-related statements were used to assess community pharmacists&#x2019; perceptions toward hypertensive counseling. The statements and corresponding responses are presented in 
                    <xref ref-type="table" rid="T3">
Table 3</xref>. While the majority of pharmacists (95%) agreed that providing patient counseling and necessary information about antihypertensive medications is part of a community pharmacists&#x2019; professional responsibility (Mean: 4.35 &#x00b1; 0.74), 71% agreed that it is not easily practiced and that more effort is needed to integrate it into daily pharmacy practice (Mean: 3.80 &#x00b1; 0.81). Approximately 98% of respondents agreed that counseling by community pharmacists improves the patient-pharmacist relationship (Mean: 4.45 &#x00b1; 0.63), and a similar proportion agreed that it helps ensure patients receive adequate and beneficial information about their medical conditions and medications (Mean: 4.40 &#x00b1; 0.63). Most pharmacists (96%) also agreed that counseling plays an important role in promoting patients&#x2019; adherence to antihypertensive medications (Mean: 4.31 &#x00b1; 0.62). Regarding knowledge and skills, 90% believed that counseling requires more advanced knowledge and skills than a basic understanding or experience in pharmacy practice (Mean: 4.25 &#x00b1; 0.79), while 89% felt they possessed the necessary proficiency to provide effective counseling (Mean: 4.19 &#x00b1; 0.75). In terms of confidence, 86% expressed confidence in counseling patients on hypertension and antihypertensive medications (Mean: 4.11 &#x00b1; 0.72), and nearly all respondents (98%) indicated a willingness to search for information they were unfamiliar with to address patient concerns (Mean: 4.36 &#x00b1; 0.51). The overall mean attitude score among community pharmacists was 38.26 &#x00b1; 3.67. Based on the predefined cut-off, 46% of respondents demonstrated a positive attitude, while 54% were categorized as having a negative attitude toward hypertensive counseling.</p>
                <table-wrap id="T3" orientation="portrait" position="float">
                    <label>
Table 3. </label>
                    <caption>
                        <title>Community pharmacists&#x2019; attitude towards provision of hypertensive counseling (n=114).</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="2" valign="top">Statements</th>
                                <th align="left" colspan="1" rowspan="2" valign="top">Min, Max</th>
                                <th align="left" colspan="5" rowspan="1" valign="top">Responses n (%)</th>
                                <th align="left" colspan="1" rowspan="2" valign="top">
Mean &#x00b1; SD</th>
                            </tr>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Strongly agree</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">
Agree</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">
Neutral</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">
Disagree</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">
Strongly disagree</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">I think providing patient counseling and necessary information about antihypertensive medications is part of a community pharmacists' professional responsibility.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1, 5</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">51 (44.73)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">57 (50.00)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">3 (2.63)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1 (0.87)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2 (1.75)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4.35 &#x00b1; 0.74</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">While patient counseling is a key responsibility of community pharmacists, I believe more effort is needed to integrate it into daily practice.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2, 5</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">20 (17.54)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">61 (53.50)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">24 (21.05)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">9 (7.89)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0 (0)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">3.80 &#x00b1; 0.81</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">I believe that counseling by community pharmacists improves the patient-pharmacist relationship.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1, 5</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">57 (50.00)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">55 (48.24)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0 (0)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1 (0.87)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1 (0.87)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4.45 &#x00b1; 0.63</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">I believe that by providing counseling, community pharmacists can ensure patients receive adequate and beneficial information about their medical conditions and medications.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1, 5</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">51 (44.73)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">61 (53.50)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0 (0)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1 (0.87)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1 (0.87)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4.40 &#x00b1; 0.63</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">I believe that community pharmacist counseling plays an important role in ensuring patients&#x2019; adherence to their antihypertensive medications.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2, 5</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">43 (37.71)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">67 (58.77)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1 (0.87)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">3 (2.63)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0 (0)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4.31 &#x00b1; 0.62</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">I believe providing counseling requires more knowledge and skill than a basic understanding or experience in pharmacy practice.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2, 5</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">47 (41.22)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">56 (49.12)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4 (3.50)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">7 (6.14)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0 (0)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4.25 &#x00b1; 0.79</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">I believe I have the knowledge and skills necessary to provide patient counseling.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1, 5</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">39 (34.21)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">62 (54.38)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">11 (9.64)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0 (0)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2 (1.75)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4.19 &#x00b1; 0.75</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">I am confident when counseling patients on hypertension and antihypertensive medications.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2, 5</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">33 (28.94)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">65 (57.01)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">12 (10.52)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4 (3.50)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0 (0)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4.11 &#x00b1; 0.72</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">I am willing to search for information I am unfamiliar with to address a patient&#x2019;s concerns.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">3, 5</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">44 (38.59)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">68 (59.64)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2 (1.75)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0 (0)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0 (0)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4.36 &#x00b1; 0.51</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Summary</bold>
</td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Mean score &#x00b1; SD (95% CI)</td>
                                <td align="left" colspan="7" rowspan="1" valign="top">38.26 &#x00b1; 3.67 (37.58-38.94)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Range</td>
                                <td align="left" colspan="7" rowspan="1" valign="top">29-45</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Negative attitude (&#x2264;38)</td>
                                <td align="left" colspan="7" rowspan="1" valign="top">61 (53.50)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Positive attitude (&#x2265;39)</td>
                                <td align="left" colspan="7" rowspan="1" valign="top">53 (46.49)</td>
                            </tr>
                        </tbody>
                    </table>
                    <table-wrap-foot>
                        <p>

                            <bold>Abbreviations:</bold> CI: Confidence Interval; Min, Max: Minimum and maximum score range per item; SD: Standard Deviation.</p>
                    </table-wrap-foot>
                </table-wrap>
                <p>Nine practice-related statements were used to assess community pharmacists&#x2019; engagement in hypertensive counseling. 
                    <xref ref-type="table" rid="T4">
Table 4</xref> describes the practice-based statements and corresponding responses of the community pharmacists. Sixty-three percent of pharmacists reported that they always or often counsel patients who come to fill their hypertension prescriptions, while 25% stated they do so sometimes (Mean: 3.80 &#x00b1; 1.01). A higher proportion (75%) indicated that they update their knowledge about hypertension and antihypertensive medications at least often throughout the year (Mean: 4.13 &#x00b1; 0.83). In terms of the depth of counseling provided, 61% reported that their counseling sessions last more than five minutes either always or often (Mean: 3.73 &#x00b1; 1.07). A majority (81%) stated that they always counsel patients on the proper use of each medication (Mean: 4.42 &#x00b1; 0.86), and 60% reported that they always or often provide counseling on the side effects of antihypertensive medications (Mean: 3.78 &#x00b1; 1.14). Additionally, 69% stated that they consistently check for and counsel patients about potential drug interactions (Mean: 3.94 &#x00b1; 1.00). Most pharmacists (75%) indicated that they always or often counsel patients about the importance of adherence to antihypertensive therapy (Mean: 4.28 &#x00b1; 0.91), and 74% reported asking patients about their blood pressure readings and advising medical consultation if needed (Mean: 4.11 &#x00b1; 0.99). Furthermore, 79% acknowledged that patients&#x2019; personality and behavior influence their counseling practices (Mean: 4.19 &#x00b1; 0.93). The mean practice score among community pharmacists was 36.42 &#x00b1; 5.85. Based on the predefined cut-off, 51% of respondents demonstrated good practice, while 49% were categorized as having poor practice toward hypertensive counseling.</p>
                <table-wrap id="T4" orientation="portrait" position="float">
                    <label>
Table 4. </label>
                    <caption>
                        <title>Community pharmacists&#x2019; practice in regard to provision of hypertensive counseling (n=114).</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="2" valign="top">Statements</th>
                                <th align="left" colspan="1" rowspan="2" valign="top">Min, Max</th>
                                <th align="left" colspan="5" rowspan="1" valign="top">Responses n (%)</th>
                                <th align="left" colspan="1" rowspan="2" valign="top">
Mean &#x00b1; SD</th>
                            </tr>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">
Always</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">
Often</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">
Sometimes</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">
Rarely</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">
Never</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">How often do you counsel patients who come to fill their hypertension prescriptions?</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1, 5</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">34 (29.82)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">38 (33.33)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">29 (25.43)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">12 (10.52)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1 (0.87)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">3.80 &#x00b1; 1.01</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">How often do you update your knowledge about hypertension and antihypertensive medications in a year?</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2, 5</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">46 (40.35)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">39 (34.21)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">27 (23.68)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2 (1.75)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0 (0)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4.13 &#x00b1; 0.83</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">How often do you provide patient counseling sessions that last more than 5 minutes?</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1, 5</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">34 (29.82)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">35 (30.70)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">27 (23.68)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">17 (14.91)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1 (0.87)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">3.73 &#x00b1; 1.07</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">How often do you counsel patients on the proper use of each medication?</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2, 5</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">74 (64.91)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">18 (15.78)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">19 (16.66)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">3 (2.63)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0 (0)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4.42 &#x00b1; 0.86</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">How often do you counsel patients about the side effects of antihypertensive medications?</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1, 5</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">42 (36.84)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">26 (22.80)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">28 (24.56)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">16 (14.03)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2 (1.75)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">3.78 &#x00b1; 1.14</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">How often do you check for and counsel patients about interactions involving antihypertensive medications?</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1, 5</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">40 (35.08)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">39 (34.21)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">27 (23.68)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">5 (4.38)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">3 (2.63)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">3.94 &#x00b1; 1.00</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">How often do you counsel patients about the importance of adhering to antihypertensive medications?</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2, 5</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">64 (56.14)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">22 (19.29)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">24 (21.05)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4 (3.50)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0 (0)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4.28 &#x00b1; 0.91</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">How often do you ask patients with hypertension about their blood pressure readings and advise them to seek medical attention if needed?</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1, 5</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">52 (45.61)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">32 (28.07)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">23 (20.17)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">5 (4.38)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2 (1.75)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4.11 &#x00b1; 0.99</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">How often do patients&#x2019; personality and behavior influence your counseling practice?</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1, 5</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">53 (46.49)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">37 (32.45)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">19 (16.66)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">3 (2.63)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2 (1.75)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4.19 &#x00b1; 0.93</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Summary</bold>
</td>
                                <td colspan="7" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Mean score &#x00b1; SD (95% CI)</td>
                                <td align="left" colspan="7" rowspan="1" valign="top">36.42 &#x00b1; 5.85 (35.34-37.51)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Range</td>
                                <td align="left" colspan="7" rowspan="1" valign="top">17-45</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Poor practice (&#x2264;38)</td>
                                <td align="left" colspan="7" rowspan="1" valign="top">56 (49.12)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Good practice (&#x2265;39)</td>
                                <td align="left" colspan="7" rowspan="1" valign="top">58 (50.87)</td>
                            </tr>
                        </tbody>
                    </table>
                    <table-wrap-foot>
                        <p>

                            <bold>Abbreviations:</bold> CI: Confidence Interval; Min, Max: Minimum and maximum score range per item; SD: Standard Deviation.</p>
                    </table-wrap-foot>
                </table-wrap>
            </sec>
            <sec id="sec14">
                <title>Comparison between demographic and professional characteristics with knowledge, attitude, and practice scores</title>
                <p>
                    <xref ref-type="table" rid="T5">
Table 5</xref> shows the comparison of mean KAP scores across various demographic and professional characteristics of community pharmacists. A significant difference in mean knowledge scores was observed based on employment status (p = 0.0145), with full-time pharmacists scoring higher (4.98 &#x00b1; 1.15) than part-time pharmacists (4.09 &#x00b1; 1.12). In the attitude domain, several characteristics showed statistically significant differences in mean scores. Male pharmacists had higher mean attitude scores (39.05 &#x00b1; 3.67) compared to female pharmacists (37.38 &#x00b1; 3.70; p = 0.0154). Education level was also significantly associated with mean attitude scores (p = 0.0262), with pharmacists holding a Master&#x2019;s degree reporting the highest mean score (39.88 &#x00b1; 3.69), followed by those with a Doctor of Pharmacy degree (38.90 &#x00b1; 3.72) and a Bachelor&#x2019;s degree (37.67 &#x00b1; 3.67). Years of experience showed a significant association as well (p = 0.0142), where pharmacists with &#x2265;5 years of experience scored higher mean attitude scores (38.83 &#x00b1; 3.69) than those with less experience (37.02 &#x00b1; 3.68). Furthermore, the number of patients counseled per week was significantly associated with mean attitude scores (p = 0.0418), with those counseling &#x2265;100 patients scoring higher (39.31 &#x00b1; 3.68) than those counseling fewer than 100 (37.79 &#x00b1; 3.69). In the practice domain, years of experience (p = 0.0339) and number of patients counseled per week (p = 0.0015) were significantly associated with mean practice scores. Pharmacists with &#x2265;5 years of experience had higher mean practice scores (37.21 &#x00b1; 5.86) compared to those with &lt;5 years (34.72 &#x00b1; 5.88), and those counseling &#x2265;100 patients weekly scored higher (39.00 &#x00b1; 5.90) than those counseling &lt;100 (35.29 &#x00b1; 5.86).</p>
                <table-wrap id="T5" orientation="portrait" position="float">
                    <label>
Table 5. </label>
                    <caption>
                        <title>Comparison of knowledge, attitude, and practice scores across demographic and professional characteristics of community pharmacists.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="2" valign="top">Variables</th>
                                <th align="left" colspan="2" rowspan="1" valign="top">Knowledge</th>
                                <th align="left" colspan="2" rowspan="1" valign="top">Attitude</th>
                                <th align="left" colspan="2" rowspan="1" valign="top">Practice</th>
                            </tr>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">
Mean &#x00b1; SD</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">

                                    <italic toggle="yes">P</italic>-value</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">
Mean &#x00b1; SD</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">

                                    <italic toggle="yes">P</italic>-value</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">
Mean &#x00b1; SD</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">

                                    <italic toggle="yes">P</italic>-value</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Age</bold>
                                    <xref ref-type="table-fn" rid="tfn1">
                                        <sup>A</sup>
                                    </xref>
                                </td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">&#x2265;35 years</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4.81 &#x00b1; 1.15</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.4968</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">38.30 &#x00b1; 3.69</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.8983</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">37.20 &#x00b1; 5.86</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.1764</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">&lt;35 years</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4.96 &#x00b1; 1.16</td>
                                <td colspan="1" rowspan="1"/>
                                <td align="left" colspan="1" rowspan="1" valign="top">38.22 &#x00b1; 3.68</td>
                                <td colspan="1" rowspan="1"/>
                                <td align="left" colspan="1" rowspan="1" valign="top">35.71 &#x00b1; 5.88</td>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Gender</bold>
                                    <xref ref-type="table-fn" rid="tfn1">
                                        <sup>A</sup>
                                    </xref>
                                </td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Male</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">5.01 &#x00b1; 1.15</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.2364</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">39.05 &#x00b1; 3.67</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0154
                                    <xref ref-type="table-fn" rid="tfn3">*</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">37.40 &#x00b1; 5.85</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0620</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Female</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4.75 &#x00b1; 1.16</td>
                                <td colspan="1" rowspan="1"/>
                                <td align="left" colspan="1" rowspan="1" valign="top">37.38 &#x00b1; 3.70</td>
                                <td colspan="1" rowspan="1"/>
                                <td align="left" colspan="1" rowspan="1" valign="top">35.35 &#x00b1; 5.90</td>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Level of education</bold>
                                    <xref ref-type="table-fn" rid="tfn2">
                                        <sup>B</sup>
                                    </xref>
                                </td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Doctor of Pharmacy</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">5.10 &#x00b1; 1.09</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.6972</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">38.90 &#x00b1; 3.72</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0262
                                    <xref ref-type="table-fn" rid="tfn3">*</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">37.60 &#x00b1; 6.02</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.5408</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Masters</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">5.00 &#x00b1; 1.16</td>
                                <td colspan="1" rowspan="1"/>
                                <td align="left" colspan="1" rowspan="1" valign="top">39.88 &#x00b1; 3.69</td>
                                <td colspan="1" rowspan="1"/>
                                <td align="left" colspan="1" rowspan="1" valign="top">35.4 &#x00b1; 5.93</td>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Bachelors</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4.83 &#x00b1; 1.15</td>
                                <td colspan="1" rowspan="1"/>
                                <td align="left" colspan="1" rowspan="1" valign="top">37.67 &#x00b1; 3.67</td>
                                <td colspan="1" rowspan="1"/>
                                <td align="left" colspan="1" rowspan="1" valign="top">36.60 &#x00b1; 5.85</td>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Type of employment</bold>
                                    <xref ref-type="table-fn" rid="tfn1">
                                        <sup>A</sup>
                                    </xref>
                                </td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Full-time
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4.98 &#x00b1; 1.15</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0145
                                    <xref ref-type="table-fn" rid="tfn3">*</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">38.32 &#x00b1; 3.67</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.6135</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">36.77 &#x00b1; 5.85</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0526</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Part-time
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4.09 &#x00b1; 1.12</td>
                                <td colspan="1" rowspan="1"/>
                                <td align="left" colspan="1" rowspan="1" valign="top">37.72 &#x00b1; 3.88</td>
                                <td colspan="1" rowspan="1"/>
                                <td align="left" colspan="1" rowspan="1" valign="top">33.18 &#x00b1; 6.19</td>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Years of experience</bold>
                                    <xref ref-type="table-fn" rid="tfn1">
                                        <sup>A</sup>
                                    </xref>
                                </td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">&#x2265;5 years</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4.83 &#x00b1; 1.15</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.4058</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">38.83 &#x00b1; 3.69</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0142
                                    <xref ref-type="table-fn" rid="tfn3">*</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">37.21 &#x00b1; 5.86</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0339
                                    <xref ref-type="table-fn" rid="tfn3">*</xref>
                                </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">&lt;5 years</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">5.02 &#x00b1; 1.16</td>
                                <td colspan="1" rowspan="1"/>
                                <td align="left" colspan="1" rowspan="1" valign="top">37.02 &#x00b1; 3.68</td>
                                <td colspan="1" rowspan="1"/>
                                <td align="left" colspan="1" rowspan="1" valign="top">34.72 &#x00b1; 5.88</td>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Average number of patients counseled in a week</bold>
                                    <xref ref-type="table-fn" rid="tfn1">
                                        <sup>A</sup>
                                    </xref>
                                </td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">&#x2265;100</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4.80 &#x00b1; 1.16</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.5623</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">39.31 &#x00b1; 3.68</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0418
                                    <xref ref-type="table-fn" rid="tfn3">*</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">39.00 &#x00b1; 5.90</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0015
                                    <xref ref-type="table-fn" rid="tfn3">*</xref>
                                </td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">&lt;100</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4.93 &#x00b1; 1.15</td>
                                <td colspan="1" rowspan="1"/>
                                <td align="left" colspan="1" rowspan="1" valign="top">37.79 &#x00b1; 3.69</td>
                                <td colspan="1" rowspan="1"/>
                                <td align="left" colspan="1" rowspan="1" valign="top">35.29 &#x00b1; 5.86</td>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Knowledge</bold>
                                    <xref ref-type="table-fn" rid="tfn1">
                                        <sup>A</sup>
                                    </xref>
                                </td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Good</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">38.43 &#x00b1; 3.67</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.4402</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">36.56 &#x00b1; 5.85</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.7124</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Poor</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">37.85 &#x00b1; 3.70</td>
                                <td colspan="1" rowspan="1"/>
                                <td align="left" colspan="1" rowspan="1" valign="top">36.11 &#x00b1; 5.96</td>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Attitude</bold>
                                    <xref ref-type="table-fn" rid="tfn1">
                                        <sup>A</sup>
                                    </xref>
                                </td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Positive</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">37.05 &#x00b1; 5.85</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.2890</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Negative</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">35.88 &#x00b1; 5.86</td>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                        </tbody>
                    </table>
                    <table-wrap-foot>
                        <p>

                            <bold>Abbreviations:</bold> 
                            <italic toggle="yes">P</italic>-value: Probability value; SD: Standard Deviation.</p>
                        <fn-group content-type="footnotes">
                            <fn id="tfn1">
                                <label>
                                    <sup>A</sup>
                                </label>
                                <p>Student T-test.</p>
                            </fn>
                            <fn id="tfn2">
                                <label>
                                    <sup>B</sup>
                                </label>
                                <p>ANOVA test.</p>
                            </fn>
                            <fn id="tfn3">
                                <label>*</label>
                                <p>A 
                                    <italic toggle="yes">p</italic>-value &lt; 0.05 level was considered to be statistically significant.</p>
                            </fn>
                        </fn-group>
                    </table-wrap-foot>
                </table-wrap>
            </sec>
            <sec id="sec15">
                <title>Factors associated with knowledge, attitude, and practice scores among community pharmacists</title>
                <p>
                    <xref ref-type="table" rid="T6">
Table 6</xref> presents the results of regression models used to identify independent predictors of KAP scores, controlling for the influence of other variables. In the knowledge domain, only type of employment remained a significant predictor, with full-time pharmacists predicted to have higher knowledge scores than part-time ones (B = 0.8393, 
                    <italic toggle="yes">p</italic> = 0.0305). For attitude scores, three variables remained significant in the multiple model: gender, education level, and practice score. Female pharmacists scored significantly lower than males by 1.4344 units (B = -1.4344, 
                    <italic toggle="yes">p</italic> = 0.0289). Each increase in education level (from Bachelor&#x2019;s degree to Doctor of Pharmacy degree to Master&#x2019;s degree) was associated with a 1.2138-unit increase in attitude score (
                    <italic toggle="yes">p</italic> = 0.0021). Practice score also positively influenced attitude, with each unit increase in practice score associated with a 0.1436-unit increase in attitude score (
                    <italic toggle="yes">p</italic> = 0.0111). In the practice domain, the number of patients counseled per week and attitude score were significant predictors. Pharmacists counseling more patients weekly had higher practice scores, with each additional patient per week associated with a 0.0162-point increase in practice score (
                    <italic toggle="yes">p</italic> = 0.0007). Similarly, a 1-point increase in attitude score was associated with a 0.3430-point increase in practice score (
                    <italic toggle="yes">p</italic>
 = 0.0156).</p>
                <table-wrap id="T6" orientation="portrait" position="float">
                    <label>
Table 6. </label>
                    <caption>
                        <title>Determinants of knowledge, attitude, and practice scores among community pharmacists.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="2" valign="top">Independent variables</th>
                                <th align="left" colspan="3" rowspan="1" valign="top">Simple linear regression</th>
                                <th align="left" colspan="3" rowspan="1" valign="top">Multiple linear regression</th>
                            </tr>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">B</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">

                                    <italic toggle="yes">P</italic>-value</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">
95% CI</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">B</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">

                                    <italic toggle="yes">P</italic>-value</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">
95% CI</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Knowledge</bold>
</td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Age</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0083</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.5228</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-0.0175-0.0341</td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Gender</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-0.2574</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.2364</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-0.6863-0.1715</td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Level of education</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0933</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.4769</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-0.1661-0.3527</td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Type of employment</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.8897</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0145
                                    <xref ref-type="table-fn" rid="tfn4">*</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.1801-1.5993</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.8393</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0305
                                    <xref ref-type="table-fn" rid="tfn4">*</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0802-1.5984</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Years of experience</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-0.0065</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.6989</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-0.0398-0.0268</td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Average number of patients counseled in a week</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0004</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.6490</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-0.0014-0.0022</td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Attitude</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-0.0195</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.5113</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-0.0782-0.0392</td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Practice</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-0.0067</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.7211</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-0.0437-0.0303</td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Attitude</bold>
</td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Age</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0101</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.8058</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-0.0712-0.0914</td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Gender</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-1.6611</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0154
                                    <xref ref-type="table-fn" rid="tfn4">*</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-2.9996-0.3226</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-1.4344</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0289
                                    <xref ref-type="table-fn" rid="tfn4">*</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-2.7184-0.1504</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Level of education</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1.1121</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0069
                                    <xref ref-type="table-fn" rid="tfn4">*</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.3125-1.9117</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1.2138</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0021
                                    <xref ref-type="table-fn" rid="tfn4">*</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.4508-1.9768</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Type of employment</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.5931</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.6135</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-1.7287-2.9149</td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Years of experience</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0693</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.1930</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-0.0356-0.1742</td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Average number of patients counseled in a week</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0030</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.3398</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-0.0031-0.0091</td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Knowledge</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-0.198</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.5113</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-0.7944-0.3984</td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Practice</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.1527</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0092
                                    <xref ref-type="table-fn" rid="tfn4">*</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0388-0.2666</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.1436</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0111
                                    <xref ref-type="table-fn" rid="tfn4">*</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0335-0.2538</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Practice</bold>
</td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Age</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0624</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.3408</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-0.0666-0.1914</td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Gender</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-2.0481</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0620</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-4.1995-0.1033</td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Level of education</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-0.5074</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.4455</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-1.8211-0.8063</td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Type of employment</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">3.5949</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0526</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-0.0425-7.2323</td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Years of experience</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.1347</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.1114</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-0.0314-0.3008</td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Average number of patients counseled in a week</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0172</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0004
                                    <xref ref-type="table-fn" rid="tfn4">*</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.008-0.0264</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0162</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0007
                                    <xref ref-type="table-fn" rid="tfn4">*</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0070-0.0254</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Knowledge</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-0.1714</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.7211</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-1.1233-0.7805</td>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                                <td colspan="1" rowspan="1"/>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Attitude</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.3870</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0092
                                    <xref ref-type="table-fn" rid="tfn4">*</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0979-0.6761</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.3430</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0156
                                    <xref ref-type="table-fn" rid="tfn4">*</xref>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0661-0.6198</td>
                            </tr>
                        </tbody>
                    </table>
                    <table-wrap-foot>
                        <p>

                            <bold>Abbreviations:</bold> B: Regression coefficient; CI: Confidence Interval; 
                            <italic toggle="yes">P</italic>-value: Probability value.</p>
                        <fn-group content-type="footnotes">
                            <fn id="tfn4">
                                <label>*</label>
                                <p>A 
                                    <italic toggle="yes">p</italic>-value &lt; 0.05 level was considered to be statistically significant.</p>
                            </fn>
                        </fn-group>
                    </table-wrap-foot>
                </table-wrap>
            </sec>
            <sec id="sec16">
                <title>Correlation between knowledge, attitude, and practice</title>
                <p>
                    <xref ref-type="table" rid="T7">
Table 7</xref> presents the correlation between KAP scores among community pharmacists. Pearson correlation analysis showed a significant positive correlation between attitude and practice (r = 0.2431, p = 0.0091), indicating that pharmacists with more positive attitudes were more likely to engage in better practice behaviors. This contrasts with the findings in 
                    <xref ref-type="table" rid="T5">
Table 5</xref>, where no association was found between attitude categories and mean practice scores. The discrepancy may be due to information loss from dichotomizing continuous attitude scores, suggesting that using full score ranges offers a more sensitive analysis.</p>
                <table-wrap id="T7" orientation="portrait" position="float">
                    <label>
Table 7. </label>
                    <caption>
                        <title>Correlation between knowledge, attitude, and practice scores.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Variable</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Correlation coefficient</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">

                                    <italic toggle="yes">P</italic>-value</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Knowledge-Attitude
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-0.0621</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.5113</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Knowledge-Practice
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-0.0338</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.7210</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Attitude-Practice
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.2430</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.0091
                                    <xref ref-type="table-fn" rid="tfn5">**</xref>
                                </td>
                            </tr>
                        </tbody>
                    </table>
                    <table-wrap-foot>
                        <p>

                            <bold>Abbreviation:</bold> 
                            <italic toggle="yes">P</italic>-value: Probability value.</p>
                        <fn-group content-type="footnotes">
                            <fn id="tfn5">
                                <label>**</label>
                                <p>Correlation is significant at the 0.01 level.</p>
                            </fn>
                        </fn-group>
                    </table-wrap-foot>
                </table-wrap>
            </sec>
        </sec>
        <sec id="sec17" sec-type="discussion">
            <title>Discussion</title>
            <p>This study provides important insights into the KAP of community pharmacists in the UAE regarding hypertension counseling. Pharmacists demonstrated a good level of knowledge, moderate attitudes, and moderate engagement in counseling practices. In contrast, Chen et al. reported strong attitudes but inadequate knowledge and practice among Chinese pharmacists.
                <sup>
                    <xref ref-type="bibr" rid="ref1">1</xref>
                </sup> Similarly, the study by Wijaya et al. revealed that while Indonesian pharmacists demonstrated moderate knowledge, they exhibited good attitudes and satisfactory practices in hypertension management.
                <sup>
                    <xref ref-type="bibr" rid="ref13">13</xref>
                </sup> These comparisons suggest that although UAE pharmacists may be better informed, their motivation or confidence to actively engage in counseling may still be suboptimal. This highlights the need for interventions that address not only knowledge gaps but also attitudinal and behavioral barriers. Similar KAP discrepancies have been observed in other therapeutic areas. Studies from India,
                <sup>
                    <xref ref-type="bibr" rid="ref14">14</xref>
                </sup> Indonesia,
                <sup>
                    <xref ref-type="bibr" rid="ref15">15</xref>
                </sup> and Malaysia
                <sup>
                    <xref ref-type="bibr" rid="ref16">16</xref>
                </sup> reported that despite favorable attitudes and a strong sense of professional responsibility, pharmacists&#x2019; knowledge and practice levels remained inadequate. These findings underscore a broader trend in pharmacy practice, underscoring the persistent gap between professional intent and actual implementation. Bridging this gap may require structured continuing education, clearly defined roles, and systems-level support to ensure consistent, high-quality patient counseling.</p>
            <p>The findings from this study show that 70% of community pharmacists demonstrated good knowledge of hypertension and its management. The highest rates of correct responses were observed in identifying modifiable risk factors (96%) and complications of uncontrolled hypertension (94%). These results indicate that pharmacists are well-versed in the foundational epidemiology and pathophysiology of hypertension. Similar findings were reported in a study from Nigeria, where pharmacists displayed strong knowledge of hypertension-related complications.
                <sup>
                    <xref ref-type="bibr" rid="ref17">17</xref>
                </sup> Another study from Indonesia demonstrated high levels of understanding regarding the definition, etiology, and clinical consequences of hypertension.
                <sup>
                    <xref ref-type="bibr" rid="ref18">18</xref>
                </sup> Additionally, pharmacists in our study showed good awareness of diagnostic thresholds (85%) and the importance of blood pressure monitoring (89%), underscoring their familiarity with screening and monitoring aspects of care. This may be attributed to the growing emphasis on non-communicable disease (NCD) screening programs in community pharmacy practice across the UAE.
                <sup>
                    <xref ref-type="bibr" rid="ref19">19</xref>,
                    <xref ref-type="bibr" rid="ref20">20</xref>
                </sup> Exposure to such content during undergraduate education
                <sup>
                    <xref ref-type="bibr" rid="ref21">21</xref>,
                    <xref ref-type="bibr" rid="ref22">22</xref>
                </sup> and continuing professional development activities
                <sup>
                    <xref ref-type="bibr" rid="ref23">23</xref>
                </sup> may also play a role. However, knowledge in pharmacologic management among the participants was comparatively weaker. Only 70% correctly identified the criteria for initiating antihypertensive therapy, and just 54% recognized thiazide diuretics as a first-line option according to JNC 8 guidelines. This points to a concerning knowledge gap in evidence-based pharmacotherapy. A similar pattern was noted in Indonesia, where pharmacists performed well in lifestyle counseling but showed limited understanding of treatment guidelines and drug selection.
                <sup>
                    <xref ref-type="bibr" rid="ref18">18</xref>
                </sup> This suggests that while pharmacists are generally competent in disease recognition, there may be insufficient emphasis on the evolving aspects of hypertension pharmacotherapy in practice. Supporting this, Soubra et al. found that although community pharmacists were competent in recognizing hypertension as a chronic disease and providing basic educational support, their engagement in dynamic pharmacotherapeutic roles remained insufficient. The study revealed that pharmacists frequently performed roles related to disease education and basic management, such as measuring blood pressure and advising on lifestyle changes, but there were notable deficiencies in medication management and care plan monitoring.
                <sup>
                    <xref ref-type="bibr" rid="ref24">24</xref>
                </sup> These gaps may be due to infrequent clinical knowledge updates post-graduation, limited access to guidelines in community settings, or lack of exposure to interprofessional case discussions. In many community pharmacies, dispensing duties dominate pharmacists&#x2019; roles, leaving little room for in-depth therapeutic review or guideline-based interventions. The study by Downes et al. further emphasizes this gap. Despite referencing the ACC/AHA 2017 guidelines, many pharmacists struggled to apply blood pressure targets accurately in case-based scenarios.
                <sup>
                    <xref ref-type="bibr" rid="ref25">25</xref>
                </sup> This suggests that while pharmacists may be aware of the guidelines, they often misinterpret or inconsistently apply them, possibly due to outdated habits, personal judgment, or reliance on former recommendations. Similar patterns have been reported in the context of cholesterol guidelines. Studies by Bucheit et al.
                <sup>
                    <xref ref-type="bibr" rid="ref26">26</xref>
                </sup> and Lowenstern et al.
                <sup>
                    <xref ref-type="bibr" rid="ref27">27</xref>
                </sup> showed high awareness but poor translation into practice. These findings highlight the issue of clinical inertia and call for more effective educational interventions. Passive dissemination of guidelines may be inadequate; instead, interactive learning and performance-based feedback could improve adherence and real-world application.</p>
            <p>In the attitude domain, although individual item responses reflected strong professional values and positive beliefs toward counseling, only 46% of respondents achieved an overall &#x201c;positive attitude&#x201d; score. Notably, 95% of pharmacists agreed that counseling is a core professional responsibility, and 98% acknowledged its benefits in enhancing patient understanding and adherence. This apparent discrepancy suggests that while pharmacists endorse the importance of counseling in principle, attitudinal or contextual barriers may hinder their willingness or ability to consistently fulfill this role. Supporting this, a recent study conducted in the UAE evaluated community pharmacists&#x2019; attitudes and willingness to provide extended pharmacy services, including patient counseling. It found that over half of the participants reported below-median scores in both attitude (58.7%) and willingness (59.4%) to deliver these services.
                <sup>
                    <xref ref-type="bibr" rid="ref28">28</xref>
                </sup> Furthermore, 71% of our participants stated that counseling is not easily integrated into daily practice, indicating perceived or actual challenges within the pharmacy environment. Similar observations were made in a study from Kenya, which revealed a marked gap between pharmacists&#x2019; self-reported counseling practices and their actual behavior. While 66.7% of pharmacists claimed to provide detailed medication counseling, only 26.7% of simulated patients received adequate guidance. Additionally, 75% of pharmacists provided minimal verbal counseling beyond stating the drug name and dosage. These findings reinforce the notion that, despite widespread recognition of its importance, counseling is not consistently embedded in daily pharmacy practice.
                <sup>
                    <xref ref-type="bibr" rid="ref29">29</xref>
                </sup> The literature consistently cites high patient volumes, insufficient staffing, and lack of privacy as primary barriers to delivering comprehensive counseling.
                <sup>
                    <xref ref-type="bibr" rid="ref30">30</xref>&#x2013;
                    <xref ref-type="bibr" rid="ref32">32</xref>
                </sup> These environmental and structural limitations may contribute to the disconnect between pharmacists&#x2019; professional intent and what they are realistically able to implement in practice. Another important consideration is perceived competence. Although 89% of respondents reported having the skills to counsel patients, and 86% expressed confidence in counseling hypertensive patients, the mean scores suggest that actual confidence levels may be lower than self-reported perceptions. This aligns with a study by Summers et al., which found that many pharmacists had never received formal instruction in communication methods, contributing to a lack of confidence in patient interactions despite recognizing their importance.
                <sup>
                    <xref ref-type="bibr" rid="ref33">33</xref>
                </sup> Notably, 90% of our respondents believed that counseling requires more advanced skills than basic pharmacy experience, indicating an appreciation of the complexity involved in effective patient communication. This acknowledgment reflects growing self-awareness among pharmacists about their training needs and highlights opportunities for developing tailored skill-building programs. Similarly, in the study by Jin et al., pharmacy students demonstrated strong self-awareness regarding their limitations in communication and expressed a clear desire for further skill development.
                <sup>
                    <xref ref-type="bibr" rid="ref34">34</xref>
                </sup> Additionally, the fact that 98% of our respondents reported a willingness to seek information when uncertain demonstrates a positive learning orientation and adaptability, qualities that can be leveraged to support long-term improvements in counseling attitudes, skills, and professional growth.</p>
            <p>In the domain of practice, just over half of the pharmacists (51%) demonstrated good counseling practices, indicating moderate engagement with hypertension-related patient education. While the mean scores across individual items were generally favorable, the overall distribution suggests inconsistencies in how frequently and comprehensively these practices are applied in daily community pharmacy settings. Encouragingly, 63% of our community pharmacists reported that they always or often counsel patients when dispensing antihypertensive prescriptions, and 81% consistently provided guidance on the proper use of each medication. However, more in-depth counseling practices, such as discussing side effects (60%) and drug interactions (69%), were reported less consistently, suggesting potential barriers such as limited time, lack of privacy, or insufficient confidence in managing complex therapeutic discussions. This aligns with findings from a study in Ethiopia, where most pharmacists engaged in basic counseling on route of administration and dosage, while only a small fraction consistently addressed the purpose of medications, major drug-drug interactions, side effects, and the importance of compliance.
                <sup>
                    <xref ref-type="bibr" rid="ref35">35</xref>
                </sup> The average time spent on counseling was another key metric. Although 61% of respondents reported sessions lasting more than five minutes, this still indicates that nearly 40% of pharmacists may be delivering brief or superficial counseling encounters. This finding mirrors results from studies conducted in South Korea
                <sup>
                    <xref ref-type="bibr" rid="ref36">36</xref>
                </sup> and the United States,
                <sup>
                    <xref ref-type="bibr" rid="ref37">37</xref>
                </sup> where time constraints were cited as a major factor limiting counseling duration, despite pharmacists&#x2019; willingness to engage with patients. Since longer interactions are often needed for effective chronic disease education, this reflects the tension between operational demands and clinical responsibilities in retail pharmacy environments. Additionally, 75% of our pharmacists reported regularly updating their knowledge of hypertension management. This proactive learning behavior is encouraging and reflects a commitment to continuous professional development. However, translating knowledge into consistent practice remains a challenge, as highlighted by the gap between knowledge scores (70% with good knowledge) and practice performance (only 51% with good practice). This disconnect suggests that knowledge alone may be insufficient to drive behavioral change without institutional support and structured protocols. The American Society of Health-System Pharmacists (ASHP) emphasizes that effective patient education and counseling require more than just pharmacist knowledge. Their guidelines advocate for structured institutional support, including the development of counseling protocols and integration into healthcare teams, to ensure that pharmacists can fulfill their educational responsibilities effectively.
                <sup>
                    <xref ref-type="bibr" rid="ref38">38</xref>
                </sup> Another notable finding from our study is that 74% of pharmacists inquired about blood pressure readings and advised patients on when to seek medical attention. This proactive engagement aligns with the evolving public health role of community pharmacists and reinforces their potential to support hypertension monitoring and referral. Furthermore, 79% of the respondents acknowledged that patients&#x2019; personality and behavior influenced their counseling approach. This was corroborated by the systematic review by Qudah et al., which found that pharmacists&#x2019; participative behavior was positively associated with patients&#x2019; engagement and perceived patient cues during conversations. These findings suggest that pharmacists adjust their counseling strategies based on patients&#x2019; communication behaviors and characteristics.
                <sup>
                    <xref ref-type="bibr" rid="ref39">39</xref>
                </sup> This degree of patient-centeredness reflects a strong inclination toward individualized care, an essential factor in promoting adherence and patient satisfaction.</p>
            <p>Both bivariate and multivariable analyses were conducted, revealing that several demographic and professional factors were significantly associated with KAP domains. These associations offer valuable insights into the personal and professional characteristics that may influence pharmacists&#x2019; engagement in patient-centered care. In the bivariate analysis, multiple variables were significantly associated with mean KAP scores. Notably, full-time pharmacists demonstrated significantly higher mean knowledge scores compared to part-time pharmacists, a finding that remained consistent in the multiple regression model. This may be attributed to increased patient exposure, more consistent clinical interactions, and greater opportunities to apply and reinforce knowledge in daily practice. Full-time pharmacists may also benefit from greater access to continuing professional development or in-service training opportunities offered by employers. However, despite the plausibility of these explanations, we were unable to identify existing research that specifically compares knowledge scores between full-time and part-time pharmacists. In the attitude domain, male pharmacists had significantly higher mean scores than their female counterparts in the bivariate analysis, and gender remained an independent predictor in the regression model. This gender difference may reflect variations in confidence levels or communication styles, although evidence on gender and counseling attitude remains mixed and context-dependent. For example, a study conducted in Jordan found that male pharmacists exhibited significantly more positive attitudes toward providing extended community pharmacy services compared to females. The authors suggest that this disparity may be influenced by greater domestic caregiving responsibilities among female pharmacists, which could limit their availability or willingness to engage in additional services.
                <sup>
                    <xref ref-type="bibr" rid="ref28">28</xref>
                </sup> Conversely, other research on pharmacists&#x2019; attitudes toward expanding prescribing roles found that female pharmacists had higher mean attitude scores than males.
                <sup>
                    <xref ref-type="bibr" rid="ref40">40</xref>
                </sup> Additionally, some evidence from Middle Eastern settings suggests that male pharmacists may be more likely to hold senior or independent roles in community pharmacies, which could contribute to greater autonomy and more positive perceptions of the counseling role.
                <sup>
                    <xref ref-type="bibr" rid="ref41">41</xref>
                </sup> Education level also showed a strong and consistent association with attitude. Pharmacists holding a Master&#x2019;s degree scored the highest, followed by PharmD holders, and then Bachelor&#x2019;s degree graduates. This supports the notion that advanced academic training enhances not only knowledge but also professional disposition and readiness for patient engagement. These findings align with those of Chan et al., who reported that healthcare professionals trained in advance care planning exhibited significantly higher levels of perceived clinical relevance, willingness, and confidence compared to those without such training.
                <sup>
                    <xref ref-type="bibr" rid="ref42">42</xref>
                </sup> Similarly, a study examining pharmacists&#x2019; attitudes toward expanding their prescribing roles found that those holding a PharmD degree had higher mean attitude scores compared to those with postgraduate or BPharm degrees.
                <sup>
                    <xref ref-type="bibr" rid="ref40">40</xref>
                </sup> This suggests that advanced clinical training, such as that provided in PharmD programs, may enhance confidence and willingness to engage in expanded patient care roles, including proactive counseling. Further supporting this, a study investigating the effects of postgraduate training in depression care found that pharmacists who received specialized training engaged in longer consultations and provided more comprehensive counseling, including discussions on lifestyle and psychosocial factors.
                <sup>
                    <xref ref-type="bibr" rid="ref43">43</xref>
                </sup> In the practice domain, both years of experience and counseling volume were significantly associated with practice scores in the bivariate analysis. However, only counseling volume emerged as an independent predictor in the multiple regression model. The significance of counseling frequency highlights the importance of practice-based learning and routine involvement in patient care. These findings are consistent with previous literature indicating that the time spent on counseling is a significant predictor of counseling practice quality.
                <sup>
                    <xref ref-type="bibr" rid="ref44">44</xref>
                </sup>
            </p>
            <p>The correlation analysis revealed a statistically significant positive relationship between pharmacists&#x2019; attitude and practice scores (r = 0.2431, p = 0.0091), indicating that those with more positive attitudes toward hypertension counseling were more likely to engage in consistent and effective counseling practices. This finding is important because it reinforces the notion that fostering favorable attitudes among pharmacists may directly contribute to improved patient care behaviors.
                <sup>
                    <xref ref-type="bibr" rid="ref45">45</xref>&#x2013;
                    <xref ref-type="bibr" rid="ref48">48</xref>
                </sup> It also supports the theory proposed in the KAP model, where attitude serves as a motivational bridge between knowledge and actual practice.
                <sup>
                    <xref ref-type="bibr" rid="ref49">49</xref>
                </sup> Interestingly, no significant correlations were observed between knowledge and either attitude (r = -0.0621, p = 0.5113) or practice (r = -0.0338, p = 0.7210), suggesting that knowledge alone may not predict how pharmacists feel about or implement hypertension counseling in practice. It highlights the reality that knowledge, while essential, is not always sufficient to drive behavioral change without concurrent improvements in attitude and system-level enablers.</p>
            <sec id="sec18">
                <title>Strengths and limitations</title>
                <p>This study has several strengths, including nationwide coverage across all seven emirates of the UAE, which enhances representativeness. The use of a validated and reliable questionnaire, developed through expert input and pilot testing, ensured acceptable content and face validity, with satisfactory internal consistency across domains. However, limitations include the use of non-probability convenience sampling, which may have introduced selection bias and limited generalizability. The final sample size fell short of the target, potentially reducing statistical power. Additionally, reliance on self-reported data rather than objective measures may have led to social desirability bias.</p>
            </sec>
        </sec>
        <sec id="sec19" sec-type="conclusions">
            <title>Conclusions</title>
            <p>This study highlights that while a majority of community pharmacists in the UAE possess good knowledge regarding hypertension counseling, gaps remain in attitudes and practice, with less than half demonstrating a positive attitude and just over half reporting good counseling practices. Significant associations between KAP domains and demographic factors such as employment type, education, experience, and patient load suggest areas for targeted intervention. Enhancing training opportunities, reinforcing guideline-based practice, and integrating structured counseling frameworks in community pharmacy settings may help strengthen the pharmacists&#x2019; role in hypertension management and improve patient care outcomes.</p>
        </sec>
        <sec id="sec20">
            <title>Ethical considerations</title>
            <p>This study received ethical approval from the Institutional Ethics Committee of Gulf Medical University (Ref. no. IRB/COP/STD/29/Nov-2021). All procedures were conducted in accordance with established ethical standards and relevant regulatory guidelines. Data collection was anonymous, with no personally identifiable information obtained. Informed consent was obtained electronically through an online process. Before beginning the survey, participants reviewed a consent page outlining the study&#x2019;s purpose, its relevance to pharmacy practice, and its potential value to healthcare outcomes. Consent was confirmed by selecting an &#x201c;I agree&#x201d; option, which was required to access the questionnaire. Participation was entirely voluntary, and all necessary measures were taken to ensure confidentiality and protect participant privacy.</p>
        </sec>
    </body>
    <back>
        <sec id="sec23" sec-type="data-availability">
            <title>Data availability</title>
            <sec id="sec24">
                <title>Underlying data</title>
                <p>Harvard Dataverse: Assessment of Community Pharmacists&#x2019; Knowledge, Attitude, and Practice Toward Counseling Hypertensive Patients in the United Arab Emirates, 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/doi:10.7910/DVN/P0N2FZ">https://doi.org/doi:10.7910/DVN/P0N2FZ</ext-link>
                    <sup>
                        <xref ref-type="bibr" rid="ref50">50</xref>
                    </sup>
                </p>
                <p>This project contains the following underlying data:</p>
                <p>

                    <ext-link ext-link-type="uri" xlink:href="https://dataverse.harvard.edu/file.xhtml?fileId=11581957&amp;version=3.0">Dataset.xlsx</ext-link>
                </p>
                <p>Data are publicly available under the terms of the 
                    <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/publicdomain/zero/1.0/deed.en">Creative Commons CC0 1.0 Universal Public Domain Dedication</ext-link> (CC0 1.0).</p>
            </sec>
            <sec id="sec25">
                <title>Extended data</title>
                <p>Harvard Dataverse: Assessment of Community Pharmacists&#x2019; Knowledge, Attitude, and Practice Toward Counseling Hypertensive Patients in the United Arab Emirates, 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/doi:10.7910/DVN/P0N2FZ">https://doi.org/doi:10.7910/DVN/P0N2FZ</ext-link>
                    <sup>
                        <xref ref-type="bibr" rid="ref50">50</xref>
                    </sup>
                </p>
                <p>This project contains the following underlying data:</p>
                <p>Questionnaire.pdf</p>
                <p>Data are publicly available under the terms of the 
                    <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/publicdomain/zero/1.0/deed.en">Creative Commons CC0 1.0 Universal Public Domain Dedication</ext-link> (CC0 1.0).</p>
            </sec>
        </sec>
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                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Guarna</surname>
                        <given-names>Giuliana</given-names>
                    </name>
                    <xref ref-type="aff" rid="r411111a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-5095-7201</uri>
                </contrib>
                <aff id="r411111a1">
                    <label>1</label>McMaster University, Hamilton, Ontario, Canada</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>12</day>
                <month>9</month>
                <year>2025</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2025 Guarna G</copyright-statement>
                <copyright-year>2025</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport411111" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.166264.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>Partly for appropriate study design - why was convenience sampling chosen as opposed to directly contacting the known pharmacies? Please justify. You will have self selection bias of those who feel strongly negative or positive towards the role of community pharmacists in counselling re: HTN&#x00a0;</p>
            <p> </p>
            <p> In results you mention that response rate with 60% - this is erroneous. You note earlier that your anticipated&#x00a0; possible sample size is 2500 licensed community pharmacists? Did you not have it available to ALL of these pharmacists? your COMPLETION rate is 60% but your response rate would actually be 120/2500.&#x00a0;</p>
            <p> </p>
            <p> re "These findings align with those of Chan et al., who reported that healthcare professionals trained in advance care planning exhibited significantly higher levels of perceived clinical relevance, willingness, and confidence compared to those without such training" I do not think that reference 42 actually is the evidence for the point you made prior. I would find another source or remove this.&#x00a0;</p>
            <p> </p>
            <p> I think this should be cited specifically in your background section as to what you are using to define the threshold for hypertension, as this would not be universal dx for HTN. American guidelines suggest 130/80 is the dx threshold for HTN. - "the majority of pharmacists correctly identified key diagnostic criteria for hypertension, with 85% recognizing that hypertension is diagnosed when systolic blood pressure is &#x2265;140 mmHg and/or diastolic blood pressure is &#x2265;90 mmHg (Mean: 0.85 &#x00b1; 0.35)"&#x00a0;</p>
            <p> </p>
            <p> I think this article could be strengthened in the results section by including some qualitative analysis, you mention the survey had open ended questions.&#x00a0; were their recurring themes or salient quotes that can enhance our understanding of barriers and facilitators to acquiring knowledge and completing counselling?</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Yes</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Partly</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Partly</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Yes</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Yes</p>
            <p>Reviewer Expertise:</p>
            <p>hypertensive disorders of pregnancy, quality improvement, medical education</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report402667">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.183228.r402667</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Nguyen</surname>
                        <given-names>Thang</given-names>
                    </name>
                    <xref ref-type="aff" rid="r402667a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0001-7799-4523</uri>
                </contrib>
                <aff id="r402667a1">
                    <label>1</label>Can Tho University of Medicine and Pharmacy, Can Tho City, Vietnam</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>19</day>
                <month>8</month>
                <year>2025</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2025 Nguyen T</copyright-statement>
                <copyright-year>2025</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport402667" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.166264.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>Brief summary of the article</p>
            <p> The authors report a six&#x2011;month cross&#x2011;sectional online survey assessing knowledge, attitude, and practice (KAP) regarding hypertension counseling among community pharmacists across all seven emirates in the UAE. Eligibility, recruitment channels (WhatsApp, email, Facebook, LinkedIn), and consent procedures are described; 200 pharmacists accessed the link, 120 completed, and 114 were included after exclusions, as shown in the flowchart on
                <bold>&#x00a0;</bold>p.5
                <bold>&#x00a0;</bold>(
                <italic>Figure 1</italic>). The questionnaire development, content validation, pilot testing, scoring rules (knowledge 6 items; attitude and practice 9 Likert items each), and statistical methods (t&#x2011;tests/ANOVA, simple and stepwise multiple linear regression) are outlined.&#x00a0;</p>
            <p> Key findings: 70% had &#x201c;good knowledge&#x201d;, 46% &#x201c;positive attitude&#x201d;, and 51% &#x201c;good practice&#x201d;. Knowledge was higher among full&#x2011;time vs part&#x2011;time pharmacists; attitude was associated with gender and education; practice was associated with counseling volume. Attitude and practice correlated positively (r&#x2248;0.24). Detailed results appear in&#x00a0;Tables 1&#x2013;7&#x00a0;(pp.6&#x2013;13). Source data (dataset and questionnaire) are deposited on Harvard Dataverse; the Data Availability section is on&#x00a0;p.16.</p>
            <p> </p>
            <p> </p>
            <p> Major comments (must address to be scientifically sound) 
                <list list-type="order">
                    <list-item>
                        <p>Content validity threshold appears misapplied for a 5&#x2011;expert panel</p>
                        <p> In Methods (p.4), items were &#x201c;retained if&#x00a0;CVR &gt; 0.78&#x201d; based on Lawshe&#x2019;s method, with five academic experts. For&#x00a0;N=5&#x00a0;experts, the&#x00a0;critical CVR is ~0.99, not 0.78; 0.78 applies only to larger panels. Please (a) clarify whether you computed&#x00a0;CVR&#x00a0;(Lawshe) or&#x00a0;item&#x2011;level CVI&#x00a0;(Lynn/Polit); (b) if CVR was used,&#x00a0;recompute with the correct critical value for N=5&#x00a0;(report item&#x2011;level CVR and which items would be retained), and (c) update reliability on the&#x00a0;full sample (n=114)&#x00a0;after any item changes.&#x00a0;</p>
                    </list-item>
                    <list-item>
                        <p>KAP scoring and dichotomization</p>
                        <p> All three domains were dichotomized at the&#x00a0;sample mean&#x00a0;(&#x201c;good/poor&#x201d; or &#x201c;positive/negative&#x201d;), which is arbitrary and information&#x2011;losing (pp.4, 7&#x2013;10). Notably, you yourself show that dichotomization obscures relationships (the text on&#x00a0;p.12notes the discrepancy between Table 5 and Table 7 due to information loss). Please treat KAP as&#x00a0;continuous
                            <bold> </bold>outcomes&#x00a0;in the primary analyses, report&#x00a0;effect sizes and 95% CIs, and, if you wish to provide prevalence, use&#x00a0;pre&#x2011;specified, defensible thresholds&#x00a0;(e.g., knowledge &#x2265;80% correct; Likert mean &#x2265;4/5). Provide sensitivity analyses comparing continuous vs thresholded results.&#x00a0;</p>
                    </list-item>
                    <list-item>
                        <p>Attitude scale coding needs clarification (likely reverse&#x2011;scoring required)</p>
                        <p> Table 3 (p.9) includes a barrier&#x2011;framed item (&#x201c;more effort is needed to integrate counseling into daily practice&#x201d;) that appears to have been scored in the same &#x201c;agreement = higher attitude&#x201d; direction as pro&#x2011;attitude items. Please list the&#x00a0;coding of each item&#x00a0;(which items were reverse&#x2011;scored),&#x00a0;recompute&#x00a0;the attitude total, and&#x00a0;re&#x2011;estimate internal consistency&#x00a0;(Cronbach&#x2019;s &#x03b1;) on&#x00a0;n=114&#x00a0;(not only the pilot n=10). If the construct is multidimensional, consider an&#x00a0;exploratory factor analysis&#x00a0;to justify the total score.</p>
                    </list-item>
                    <list-item>
                        <p>Knowledge items should align with current hypertension guidelines</p>
                        <p> Knowledge statement 5 explicitly cites&#x00a0;JNC&#x2011;8&#x00a0;for first&#x2011;line therapy (p.8, Table 2). Please justify this choice and/or&#x00a0;update items and interpretation&#x00a0;to align with contemporary guidance (e.g., WHO 2021; ISH 2020) that endorse thiazide/thiazide&#x2011;like diuretics, ACEI/ARB, and CCB as first&#x2011;line classes, with frequent use of fixed&#x2011;dose combinations. If you retain JNC&#x2011;8, add a&#x00a0;sensitivity re&#x2011;scoring&#x00a0;using WHO/ISH as the reference.&#x00a0;</p>
                    </list-item>
                    <list-item>
                        <p>Sampling, precision, and survey reporting:</p>
                        <p> Only&#x00a0;114&#x00a0;participants were analyzed vs a target&#x00a0;334&#x00a0;(pp.5&#x2013;6). With n=114 and p&#x2248;0.5, the&#x00a0;95% margin of error is ~9%, so proportions should be interpreted cautiously; please report this precision post hoc and emphasize it in the limitations. In addition, because this was an&#x00a0;open, online convenience sample, please enhance reporting per&#x00a0;CHERRIES&#x00a0;(e.g., prevention of multiple entries, completeness checks, cookie/IP controls, whether items were mandatory, invitation/reminder flow, view&#x2011;to&#x2011;participation ratios by channel) and&#x00a0;CROSS&#x00a0;(sampling frame, response metrics, handling of partials, weighting, and bias mitigation), ideally as a supplementary checklist.</p>
                    </list-item>
                    <list-item>
                        <p>Statistical modeling transparency:</p>
                        <p> You used&#x00a0;stepwise multiple linear regression&#x00a0;(p.5). Please (a) specify model diagnostics (normality of residuals, linearity, multicollinearity, influential points), (b) report&#x00a0;R&#x00b2;/adjusted R&#x00b2;&#x00a0;for each model, and (c) provide&#x00a0;non&#x2011;parametric sensitivity
                            <bold> </bold>analyses&#x00a0;(Mann&#x2013;Whitney/Kruskal&#x2013;Wallis; Spearman correlations) given Likert&#x2011;based totals. Also consider controlling the false discovery rate for multiple bivariate tests.</p>
                    </list-item>
                    <list-item>
                        <p>Reproducibility materials</p>
                        <p> Data and the instrument are shared (Data Availability,
                            <bold>&#x00a0;</bold>p.16), which is excellent. Please also share the&#x00a0;analysis code&#x00a0;(e.g., SPSS syntax/R scripts) and a&#x00a0;variable dictionary/codebook&#x00a0;in the Dataverse record so that others can exactly reproduce your pipeline.</p>
                    </list-item>
                </list> </p>
            <p> Minor comments (could improve clarity and utility) 
                <list list-type="order">
                    <list-item>
                        <p>Terminology:&#x00a0;You label Section 2 as &#x201c;self&#x2011;perceived knowledge,&#x201d; but items are objectively scored True/False (pp.4, 8). Consider renaming to &#x201c;objective knowledge&#x201d; to avoid confusion</p>
                    </list-item>
                    <list-item>
                        <p>Descriptives for skewed variables:&#x00a0;The weekly counts of patients seen/counseled show very large SDs (Table 1, p.6). Add&#x00a0;median (IQR)&#x00a0;alongside mean (SD).&#x00a0;</p>
                    </list-item>
                    <list-item>
                        <p>Regional reporting
                            <bold>:</bold>&#x00a0;&#x201c;Northern Emirates&#x201d; comprises multiple emirates (Table 1). If feasible, provide a&#x00a0;by&#x2011;emirate breakdown or justify the aggregation (p.6).&#x00a0;</p>
                    </list-item>
                    <list-item>
                        <p>CIs throughout:&#x00a0;You already provide CIs in several tables; extend&#x00a0;95% CIs&#x00a0;to all key estimates (group differences, correlations) for consistency (pp.8&#x2013;13).</p>
                    </list-item>
                    <list-item>
                        <p>Data DOI formatting:&#x00a0;The Dataverse DOI appears with a duplicated prefix (&#x201c;**doi:doi:**10.7910/DVN/P0N2FZ50&#x201d;) in the Data Availability section (p.16); please correct.</p>
                    </list-item>
                </list> </p>
            <p> Interpretation of the reviewer form items</p>
            <p> - Clarity &amp; literature (Partly).&#x00a0;The manuscript is generally well organized with clear tables and a recruitment flowchart (pp.5&#x2013;13), and it cites recent UAE and global sources. However, the&#x00a0;knowledge items&#x00a0;are referenced to JNC&#x2011;8 rather than current&#x00a0;WHO 2021 / ISH 2020&#x00a0;guidance, which should be justified or updated.&#x00a0;</p>
            <p> -&#x00a0;Design &amp; technical soundness (Partly).&#x00a0;A nationwide cross&#x2011;sectional survey is appropriate for the stated aims, but&#x00a0;convenience sampling,&#x00a0;shortfall from the planned sample size, the&#x00a0;CVR threshold issue, and&#x00a0;mean&#x2011;split dichotomization&#x00a0;reduce methodological robustness.&#x00a0;</p>
            <p> -&#x00a0;Methods sufficient for replication (Partly)
                <bold>.</bold>&#x00a0;Instrument development is described and data are shared, yet essential details (item coding/reverse&#x2011;scoring, model diagnostics, CHERRIES/CROSS items) and&#x00a0;analysis code&#x00a0;are missing for full reproducibility.&#x00a0;</p>
            <p> -&#x00a0;Statistics appropriate (Partly).&#x00a0;The chosen tests are standard, but reliance on&#x00a0;stepwise regression, lack of reported diagnostics, and heavy&#x00a0;dichotomization&#x00a0;warrant revision; add&#x00a0;effect sizes&#x00a0;and&#x00a0;CIs&#x00a0;routinely and consider&#x00a0;non&#x2011;parametric&#x00a0;sensitivity analyses.&#x00a0;</p>
            <p> -&#x00a0;Underlying data available (Yes)
                <bold>.</bold>&#x00a0;Dataset and questionnaire are openly available (Data Availability,&#x00a0;p.16); please add&#x00a0;codebook and
                <bold> </bold>syntax.</p>
            <p> -&#x00a0;Conclusions supported (Partly).&#x00a0;The main message (good knowledge; room to improve attitude and practice) is broadly consistent with the data, but its strength depends on correcting the&#x00a0;measurement&#x00a0;and&#x00a0;analysis&#x00a0;issues above (CVR threshold, attitude coding, mean&#x2011;split).</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Partly</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Partly</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Partly</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Partly</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Reviewer Expertise:</p>
            <p>PharmacoTherapy and Pharmaceutical Care; Questionnaires; RCT; Systematic Review-Meta-analysis; KAP, etc.</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
    </sub-article>
</article>
