<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN" "http://jats.nlm.nih.gov/publishing/1.2/JATS-journalpublishing1.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="research-article" dtd-version="1.2" xml:lang="en">
    <front>
        <journal-meta>
            <journal-id journal-id-type="pmc">F1000Research</journal-id>
            <journal-title-group>
                <journal-title>F1000Research</journal-title>
            </journal-title-group>
            <issn pub-type="epub">2046-1402</issn>
            <publisher>
                <publisher-name>F1000 Research Limited</publisher-name>
                <publisher-loc>London, UK</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="doi">10.12688/f1000research.156316.2</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Research Article</subject>
                </subj-group>
                <subj-group>
                    <subject>Articles</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Predicting determinants of modern contraceptive use among reproductive-age women in Ethiopia using machine learning algorithms: Evidence from the Performance Monitoring and Accountability (PMA) Survey 2019 dataset</article-title>
                <fn-group content-type="pub-status">
                    <fn>
                        <p>[version 2; peer review: 2 approved, 1 approved with reservations]</p>
                    </fn>
                </fn-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author" corresp="yes">
                    <name>
                        <surname>Adem</surname>
                        <given-names>Jibril Bashir</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Investigation</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Resources</role>
                    <role content-type="http://credit.niso.org/">Software</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0003-1026-0626</uri>
                    <xref ref-type="corresp" rid="c1">a</xref>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Alhur</surname>
                        <given-names>Anas Ali</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Software</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0001-6044-7072</uri>
                    <xref ref-type="aff" rid="a2">2</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Kebede</surname>
                        <given-names>Shimels Derso</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Software</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="aff" rid="a3">3</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Walle</surname>
                        <given-names>Agmasie Damtew</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Resources</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="aff" rid="a4">4</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Mamo</surname>
                        <given-names>Daniel Niguse</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="aff" rid="a5">5</xref>
                </contrib>
                <aff id="a1">
                    <label>1</label>Public Health, Arsi University, Asella, Oromia, 193, Ethiopia</aff>
                <aff id="a2">
                    <label>2</label>Department of Health Information Management and Technology, College of Public Health, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia</aff>
                <aff id="a3">
                    <label>3</label>health Informatics, Wollo University, Dessie, Amhara, Ethiopia</aff>
                <aff id="a4">
                    <label>4</label>Health Informatics, Debre Berhan University, Debre Birhan, Amhara, Ethiopia</aff>
                <aff id="a5">
                    <label>5</label>Health Informatics, Arba Minch University, Arba Minch, Southern Nations, Nationalities, and People's Region, Ethiopia</aff>
            </contrib-group>
            <author-notes>
                <corresp id="c1">
                    <label>a</label>
                    <email xlink:href="mailto:adamjibrilbashir@gmail.com">adamjibrilbashir@gmail.com</email>
                </corresp>
                <fn fn-type="conflict">
                    <p>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>28</day>
                <month>11</month>
                <year>2025</year>
            </pub-date>
            <pub-date pub-type="collection">
                <year>2025</year>
            </pub-date>
            <volume>14</volume>
            <elocation-id>99</elocation-id>
            <history>
                <date date-type="accepted">
                    <day>17</day>
                    <month>11</month>
                    <year>2025</year>
                </date>
            </history>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2025 Adem JB et al.</copyright-statement>
                <copyright-year>2025</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <self-uri content-type="pdf" xlink:href="https://f1000research.com/articles/14-99/pdf"/>
            <abstract>
                <sec>
                    <title>Introduction</title>
                    <p>Globally, around 40% of women report unintended pregnancies, with approximately 214 million women in developing countries wanting to avoid pregnancy but not using any contraception. Modern contraceptives (MCs) are effective tools for preventing unintended pregnancies, controlling rapid population growth, and reducing fertility and maternal mortality rates, particularly in developing countries. This study aimed to identify the determinants of modern contraceptive use among Ethiopian women of reproductive age using machine learning (ML) algorithms.</p>
                </sec>
                <sec>
                    <title>Methodology</title>
                    <p>The study utilized secondary data from the 2019 Performance Monitoring and Accountability (PMA) Ethiopia survey, analyzing 8,837 samples. Preprocessing steps included data cleaning, feature engineering, dimensionality reduction, and splitting the data, with 80% used for training and 20% for testing the algorithms. Six supervised ML algorithms were employed and assessed using confusion matrices, with information gain applied to identify critical attributes for predicting MC use.</p>
                </sec>
                <sec>
                    <title>Results</title>
                    <p>Only 24% of participants used modern contraceptives [95% CI (23.1%, 24.9%)]. Extreme gradient boosting (XGB) demonstrated the highest predictive accuracy (81.97%, 95% CI {79.06%, 82.7%}) and area under the ROC curve (76.63%), followed by logistic regression (80.52%) and support vector machines (80.41%). Key determinants of MC use included starting family planning at age 20 or older, being single, having partner approval, being the wife of the household head, being between 36 and 49 years old, advice from healthcare providers, concerns about side effects, and having a household size of five or more.</p>
                </sec>
                <sec>
                    <title>Conclusion and Recommendations</title>
                    <p>The use of modern contraceptives among Ethiopian women remains low. Extreme gradient boosting proved most effective in predicting determinants of MC use. Based on the results of predictive associations, improved counseling during antenatal and postnatal care visits, promoting partner discussions on family planning, and addressing concerns about family size and contraceptive use are recommended strategies to enhance MC uptake.</p>
                </sec>
            </abstract>
            <kwd-group kwd-group-type="author">
                <kwd>Modern contraceptive methods</kwd>
                <kwd>Reproductive-age women</kwd>
                <kwd>Machine learning approach</kwd>
                <kwd>Ethiopia</kwd>
            </kwd-group>
            <funding-group>
                <funding-statement>The author(s) declared that no grants were involved in supporting this work.</funding-statement>
            </funding-group>
        </article-meta>
        <notes>
            <sec sec-type="version-changes">
                <label>Revised</label>
                <title>Amendments from Version 1</title>
                <p>This revised version of the manuscript has been thoroughly updated to incorporate all the comments and suggestions provided by the reviewers and editors. In addition to addressing the feedback, careful attention has been given to refining the language, improving the clarity and coherence of the writing, and correcting minor inconsistencies or stylistic issues present in the previous version. No substantive changes were made to the study&#x2019;s design, data, or main findings; revisions were limited to enhancing readability, precision, and overall presentation quality.</p>
            </sec>
        </notes>
    </front>
    <body>
        <def-list>
            <title>Abbreviations</title>
            <def-item>
                <term id="G1">ANC</term>
                <def>
                    <p>Antenatal Care</p>
                </def>
            </def-item>
            <def-item>
                <term id="G2">AUC</term>
                <def>
                    <p>Area under the ROC curve</p>
                </def>
            </def-item>
            <def-item>
                <term id="G3">DHS</term>
                <def>
                    <p>Demographic and Health Survey</p>
                </def>
            </def-item>
            <def-item>
                <term id="G4">EDHS</term>
                <def>
                    <p>Ethiopian Demographic and Health Survey</p>
                </def>
            </def-item>
            <def-item>
                <term id="G5">EPHI</term>
                <def>
                    <p>Ethiopian Public Health Institute</p>
                </def>
            </def-item>
            <def-item>
                <term id="G6">FP</term>
                <def>
                    <p>Family Planning</p>
                </def>
            </def-item>
            <def-item>
                <term id="G7">KNN</term>
                <def>
                    <p>K-nearest neighbors</p>
                </def>
            </def-item>
            <def-item>
                <term id="G8">LR</term>
                <def>
                    <p>Logistic Regression</p>
                </def>
            </def-item>
            <def-item>
                <term id="G9">NB</term>
                <def>
                    <p>Naive Bayes</p>
                </def>
            </def-item>
            <def-item>
                <term id="G10">PMA</term>
                <def>
                    <p>Performance monitoring and accountability</p>
                </def>
            </def-item>
            <def-item>
                <term id="G11">PNC</term>
                <def>
                    <p>Postnatal care</p>
                </def>
            </def-item>
            <def-item>
                <term id="G12">RF</term>
                <def>
                    <p>Random Forest</p>
                </def>
            </def-item>
        </def-list>
        <sec id="sec5" sec-type="intro">
            <title>Introduction</title>
            <p>Approximately 40% of women worldwide report having unwanted pregnancies.
                <sup>
                    <xref ref-type="bibr" rid="ref1">1</xref>
                </sup> In developing nations, an estimated 214 million women of reproductive age who want to avoid pregnancy do not use any method of contraception.
                <sup>
                    <xref ref-type="bibr" rid="ref2">2</xref>
                </sup> It is estimated that contraception prevents about 188 million unintended pregnancies each year, and in 2022 alone, contraception prevented more than 141 million unintended pregnancies globally.
                <sup>
                    <xref ref-type="bibr" rid="ref56">3</xref>,
                    <xref ref-type="bibr" rid="ref57">4</xref>
                </sup> Although this expectation has not yet been met in Sub-Saharan Africa, it has been observed in many other regions of the world, particularly in Asia and Latin America.
                <sup>
                    <xref ref-type="bibr" rid="ref3">5</xref>
                </sup> Sub-Saharan Africa as a whole still has the highest fertility rate worldwide.
                <sup>
                    <xref ref-type="bibr" rid="ref3">5</xref>
                </sup> According to reports from 2012 and 2017, only a small percentage of women in Africa used modern contraceptives, with estimates of 23.9% and 28.5%, respectively.
                <sup>
                    <xref ref-type="bibr" rid="ref4">6</xref>
                </sup> In a recent large population-based study, the prevalence of modern contraceptive use was estimated to be 26% among women of reproductive age in 20 African countries, with country-specific variations ranging from 6% in Guinea to 62% in Zimbabwe.
                <sup>
                    <xref ref-type="bibr" rid="ref5">7</xref>
                </sup>
            </p>
            <p>Modern contraceptive (MC) methods are a scientifically effective methods like implants, female and male condoms, injectable, contraceptive pills, standard days method, male and female sterilization, intrauterine devices, and emergency contraception to control the fertility of reproductive-aged groups of people.
                <sup>
                    <xref ref-type="bibr" rid="ref58">8</xref>&#x2013;
                    <xref ref-type="bibr" rid="ref60">10</xref>
                </sup> MCs are widely accepted to limit rapid population increases, especially in developing nations, and have been proven to be an effective approach for reducing fertility.
                <sup>
                    <xref ref-type="bibr" rid="ref6">11</xref>,
                    <xref ref-type="bibr" rid="ref7">12</xref>
                </sup> Effective use of MCs has been shown to improve birth spacing, reduce the rate of unexpected or unwanted pregnancies, lower unsafe abortions, improve maternal health, reduce infant mortality, and prevent STDs.
                <sup>
                    <xref ref-type="bibr" rid="ref61">13</xref>,
                    <xref ref-type="bibr" rid="ref62">14</xref>
                </sup> The decreases in poverty, the expansion of women&#x2019;s educational possibilities, and the ensuing sustainable population growth and economic development for nations are among the non-health benefits that have been identified.
                <sup>
                    <xref ref-type="bibr" rid="ref9">15</xref>
                </sup>
            </p>
            <p>According to a study conducted in Vietnam, the association between a woman&#x2019;s age and current contraceptive methods is shaped like an inverted &#x201c;U.&#x201d; Although the chance of using contraception was low among women aged 15 to 24, it was greater among those in the 25 to 35 age group and lowest among those aged 35 and older.
                <sup>
                    <xref ref-type="bibr" rid="ref10">16</xref>
                </sup> The adoption and use of modern contraceptive methods by women can also be influenced by their degree of education. Employed women with higher educational levels had a noticeably greater likelihood of using contraceptives than illiterate women did, according to a study of the prevalence and determinants of contraceptive usage among employed and jobless women.
                <sup>
                    <xref ref-type="bibr" rid="ref11">17</xref>
                </sup> According to a Nigerian study, women with higher (tertiary) education are four times more likely to use modern contraceptives than women with lower educational attainment.
                <sup>
                    <xref ref-type="bibr" rid="ref12">18</xref>
                </sup> In a similar vein, wives of highly educated men were more likely to accept and support the use of modern contraceptive techniques.
                <sup>
                    <xref ref-type="bibr" rid="ref13">19</xref>
                </sup>
            </p>
            <p>Numerous investigations have shown a strong correlation between place of residence and the use of modern contraceptive methods.
                <sup>
                    <xref ref-type="bibr" rid="ref14">20</xref>,
                    <xref ref-type="bibr" rid="ref15">21</xref>
                </sup> Women in urban regions are more likely than women in rural areas to use modern contraceptive techniques, although the majority of people live in rural areas.
                <sup>
                    <xref ref-type="bibr" rid="ref16">22</xref>
                </sup> In relation to modern contraceptives, a woman&#x2019;s wealth index and type of wage impact her financial status as well as her accessibility and affordability.
                <sup>
                    <xref ref-type="bibr" rid="ref17">23</xref>
                </sup> The acceptance and use of a modern contraceptive by a woman can be influenced by her marital status.
                <sup>
                    <xref ref-type="bibr" rid="ref18">24</xref>
                </sup> The choice and use of modern contraceptive methods have been linked to cultural influences, religion, and information sources, all of which have an impact on women&#x2019;s decisions.
                <sup>
                    <xref ref-type="bibr" rid="ref19">25</xref>
                </sup>
            </p>
            <p>To pinpoint the causes of the low use of modern contraceptives, numerous studies have been conducted in Ethiopia and other countries.
                <sup>
                    <xref ref-type="bibr" rid="ref14">20</xref>,
                    <xref ref-type="bibr" rid="ref15">21</xref>
                </sup> Their findings suggest that low use of contraceptives is responsible for the high fertility rates in sub-Saharan African nations, which have an adverse impact on early childbirth, high infant and maternal mortality, and a host of other socioeconomic factors.
                <sup>
                    <xref ref-type="bibr" rid="ref20">26</xref>,
                    <xref ref-type="bibr" rid="ref21">27</xref>
                </sup> Using traditional regression models, earlier research conducted in this country demonstrated the effects of socioeconomic and demographic factors related to the use of modern contraceptives, which became less accurate as the number of variables used and the potential correlations increased.
                <sup>
                    <xref ref-type="bibr" rid="ref22">28</xref>,
                    <xref ref-type="bibr" rid="ref26">29</xref>
                </sup> These traditional models usually involve problems involving multidisciplinary relationships between variables and many factors.
                <sup>
                    <xref ref-type="bibr" rid="ref27">30</xref>,
                    <xref ref-type="bibr" rid="ref28">31</xref>
                </sup>
            </p>
            <p>This study employed machine learning (ML) to address the limitations of traditional regression models, such as logistic regression, which assume linear relationships and independence among predictors, assumptions that may not be valid in complex public health datasets. In contrast, ML algorithms can efficiently handle nonlinear associations, multicolinearity, and higher-order interaction effects between socio-demographic, behavioral, and reproductive factors influencing contraceptive use. These methods thus provide greater flexibility in uncovering hidden patterns and improving predictive accuracy compared to conventional models.
                <sup>
                    <xref ref-type="bibr" rid="ref27">30</xref>,
                    <xref ref-type="bibr" rid="ref29">32</xref>,
                    <xref ref-type="bibr" rid="ref30">33</xref>
                </sup> Therefore, this study aimed to assess the determinants of modern contraceptive use among reproductive-aged women in Ethiopia using six widely used machine learning (ML) algorithms. This study sought to determine and identify consistent determinants and others of modern contraceptive use using the Performance Monitoring and Accountability (PMA) Survey 2019 dataset for currently non-pregnant reproductive-age women in Ethiopia. The most influential and consistent determinants identified based on these findings will serve as priority intervention areas for which the Ethiopian Ministry of Health and other health partners can concentrate to improve the use of modern contraceptives in Ethiopia.</p>
        </sec>
        <sec id="sec6" sec-type="methods">
            <title>Method</title>
            <sec id="sec7">
                <title>Study design</title>
                <p>A machine learning (ML) algorithm was conducted using Python and analyzed on Google Colab,
                    <sup>
                        <xref ref-type="bibr" rid="ref31">34</xref>,
                        <xref ref-type="bibr" rid="ref33">35</xref>
                    </sup> utilizing secondary data from the 2019 Performance Monitoring and Accountability (PMA) Ethiopia cross-sectional household and women&#x2019;s survey. PMA-Ethiopia is a collaborative five-year initiative (2019&#x2013;2023) involving Addis Ababa University, Johns Hopkins University, and the Federal Ministry of Health. The project comprises three key components: annual cross-sectional surveys of women aged 15&#x2013;49, longitudinal studies tracking pregnant women and new mothers, and yearly service delivery point surveys assessing health facilities.
                    <sup>
                        <xref ref-type="bibr" rid="ref34">36</xref>
                    </sup>
                </p>
            </sec>
            <sec id="sec8">
                <title>Source and study population</title>
                <p>The study sourced all reproductive-age women in Ethiopia, with the study population comprising women who participated in the 2019 PMA-Ethiopia cross-sectional survey.</p>
            </sec>
            <sec id="sec9">
                <title>Sampling method</title>
                <p>The PMA survey sample is based on a multi-stage cluster design, with urban-rural and primary fields as strata. A nationally representative number of enumeration areas are selected from each region of the country. Then, in each enumeration region, households are identified and mapped before being systematically chosen for participation in the survey round through a random process. The female participant survey is included in each household questionnaire and consists of a series of questions for all women of reproductive age (15-49) residing in that household.</p>
                <p>The household and female surveys are carried out by female data collectors, known as resident enumerators (REs) which are typically women over the age of 21 who are from or near the respective enumeration areas and hold at least a high school diploma. Each RE takes about six weeks to collect data from all selected households, eligible women, and service delivery points. The surveys include interviews among females aged 15 to 49 who are consented and screened for eligibility, as well as a random sample of health institutions, pharmacies, and retail stores that provide family planning services in the selected areas.</p>
                <p>Women are eligible for the survey if they are regular members of the household, including women staying at their parental home for the delivery and postpartum period, and self-identified as currently pregnant or less than six weeks postpartum. Female respondents are asked questions about their background, birth history, fertility desires, methods of contraception used, and other information that policymakers and program administrators may utilize to promote health and family planning.
                    <sup>
                        <xref ref-type="bibr" rid="ref34">36</xref>
                    </sup> The analysis sample was weighted to account for nonresponse and differences in selection probabilities. It was further limited to responses from women of reproductive age at the time of the survey, resulting in a weighted sample of 8,837 women.</p>
            </sec>
            <sec id="sec10">
                <title>Study variables</title>
                <p>

                    <bold>Dependent variable</bold>
                </p>
                <p>In this study, Modern contraceptive use was the dependent variable and was dichotomized into two categories: &#x2018;yes&#x2019; and &#x2018;No&#x2019;. A woman was considered to be using modern contraception if she used any of the following methods; female sterilization, implant, IUD, injectable, pill, emergency contraception, female or male condoms, cycle beads, and LAM.
                    <sup>
                        <xref ref-type="bibr" rid="ref64">37</xref>
                    </sup>
                </p>
                <p>

                    <bold>Predictor variables</bold>
                </p>
                <p>Various socio-demographic, economic, maternal and health service-related factors were included as predictor variables. Socio-demographic and economic factors included mothers&#x2019; current age (categorized in to 15-24 years, 25-34 years and 35-49 years), region (included Gambela, Harari, Southern Nations Nationalities and People (SNNP), Oromia, Somalia, Benishangul-Gumuz, Afar, Amhara, Tigray, and Afar and two cities namely Addis Ababa and Dire Dawa), residence (urban and rural), religion (Christian, Muslim and Other which includes Wakefata and Atheist) and educational level (categorized as no schooling, primary education, and secondary and above), sex of the household head (Male and Female), and relationship (grouped in to head of the household, wife, daughter or daughter-in-law, other relatives and not related), family wealth indices (poorest, middle and richest), household size( grouped in to 1-3 members, 4-5 members, 6 and above members) and marital status(grouped in to never married, Married and widowed/divorced/separated).</p>
                <p>Maternal and health service-related factors included number of under five children (grouped in to no under_5 children and 1 and more under_5 children), number of children ever born (grouped in to 1-3 children and 4 and more children), birth in the last 5 years (1-2 birth and 3-5 birth), birth in the last year (no birth and 1 birth), knowledge about reproductive methods (knows about modern methods, knows about traditional methods only, and no knowledge about any method), cesarean delivery (no and yes) and age at first birth (below 15 years, between 16 and 34 years and above 35 years) (
                    <xref ref-type="table" rid="T1">
Table 1</xref>).</p>
                <table-wrap id="T1" orientation="portrait" position="float">
                    <label>
Table 1. </label>
                    <caption>
                        <title>Variables and their descriptions.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Number</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Features</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Features&#x2019; description</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">1.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Region</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Region of the women, All administrative region in Ethiopia</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">2.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Religion</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Religion of the women</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">3.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Education level</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Highest educational level of the women during data collection</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">4.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">wealth index</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Wealth index of the HH</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">5.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Media access</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Media access of the women</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">6.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Ever been pregnant</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Women&#x2019;s history of pregnancy</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">7.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Age at first sex</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Age at sexual initiation</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">8.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Ever used FP methods</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">History of FP use</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">9.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Ever delivered in health facility</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">History of facility delivery</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">10.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">know any contraceptive method available</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Knowledge of contraceptive method</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">11.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Ageat1stfpuse</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Age at first family planning use</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">12.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Partner_fp_feeling
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Partner feeling toward FP</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">13.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Visited _ a_ facility</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Previous health facility visit history</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">14.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Relationship</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Women&#x2019;s relationship to head of the household</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">15.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Wge _ fp _ aut_ could_ conflict</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">If I use FP, there could be conflict in relationship or marriage</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">16.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">facility _ fp _ discussion</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">health care providers spoke about FP methods at health facility visits</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">17.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">newage</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Recoded age</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">18.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Norm _fp_ responsible</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">perceptions of couples using FPs as financially responsible</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">19.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Partner _ discussion</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Culture of family planning discussion with partner</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">20.</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Wge _ fp _ aut_ sideeffect _ disrupt</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">If I use FP, side effects might disrupt my relationship</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
            </sec>
            <sec id="sec11">
                <title>Data processing and analysis</title>
                <p>Variable extraction and imputation were conducted using R software version 4.4.3. Using Jupyter Notebook, the Scikit-learn machine learning (ML) algorithms were built in Python 3.11.5. We used six widely accepted machine learning algorithms to predict the determinants of modern contraceptive use in Ethiopia and compared the results of the best algorithm to the results of the traditional logistic regression model. The k-nearest neighbors (KNN) model is chosen based on its ability to detect linear and nonlinear boundaries between groups. The K value represents the number of nearest neighbors and is the core deciding factor in this classifier. The Random Forest (RF) model is used in machine learning situations because it is highly flexible and provides good predictive performance. It produces ensemble predictions that are more accurate than any of the individual predictions. The naive Bayes algorithm is a supervised machine learning algorithm that uses the Bayes theorem for classification and prediction. It has an incremental learning behavior and is not affected by training time. Logistic regression is a statistical model that is used to classify and predict different health parameters, where the target variable is dichotomous and the independent variables are independent of each other. The general framework used in the literature
                    <sup>
                        <xref ref-type="bibr" rid="ref35">38</xref>,
                        <xref ref-type="bibr" rid="ref36">39</xref>
                    </sup> based on Yufeng Guo&#x2019;s 7 machine learning steps was used in this study. The framework describes the seven steps in supervised machine learning, which are as follows: data collection, data preparation, model selection, model training, model evaluation, parameter tuning, and prediction.</p>
                <p>

                    <bold>Data source/collection</bold>
                </p>
                <p>The dataset for this study is available on the PMA Survey website and can be obtained upon formal request. A weighted sample of 8837 reproductive-age women was included in the data. The datasets analyzed in the current study are available in the PMA repository, 
                    <ext-link ext-link-type="uri" xlink:href="https://www.pmadata.org/data/available-datasets">https://www.pmadata.org/data/available-datasets
</ext-link>.</p>
                <p>

                    <bold>Data preparation:</bold> The data preprocessing techniques used in this investigation included data cleaning, data splitting, feature engineering, and dimensionality reduction. After the data were extracted, data cleaning was performed, which included finding and removing outliers from the dataset, as well as resolving missing values and uneven categories in the resulting variable. This study employed the KNN imputation approach to handle the missing values in the dataset related to the independent variables. KNN imputation was chosen over parametric methods as the dataset had a small percentage of missing data (11%), Little&#x2019;s MCAR test revealed that the missing data mechanism was Missing Completely at Random (MCAR) (p &gt; 0.05), and the relationships between the variables were not strictly linear.
                    <sup>
                        <xref ref-type="bibr" rid="ref30">33</xref>,
                        <xref ref-type="bibr" rid="ref37">40</xref>
                    </sup>
                </p>
                <p>The raw data were transformed into features that more accurately depicted the underlying issue for the predictive models, improving the accuracy of the unobserved data. Hence, among other feature engineering techniques, label encoding for coding each category of variables as a number and encoding categorical variables into numeric values for nominal variables were carried out. The process of dimension reduction was used to decrease the number of input variables for the predictive model. Having fewer input variables might lead to a simpler predictive model, which can perform better when generating predictions on new information. To ensure that only the most essential dummy variables were included, we reduced the amount of features using RFECV. Since Principal Component Analysis (PCA) is not ideal for one-hot-encoded categorical features. Using those techniques to assess the link between the independent input components and the output variable and selecting the most important independent variables, feature selection and feature extraction was utilized to forecast the target variable. This technique has frequently been used in earlier public health research to identify the factors and/or predictors of different health outcomes.
                    <sup>
                        <xref ref-type="bibr" rid="ref27">30</xref>,
                        <xref ref-type="bibr" rid="ref38">41</xref>
                    </sup>
                </p>
                <p>This study utilized a standard 80/20 split approach, where 80% of the data were used for training and the remaining 20% were used for model testing. The model was trained using the tenfold cross-validation method, which does not waste much data; this approach is highly beneficial when the number of samples is limited.
                    <sup>
                        <xref ref-type="bibr" rid="ref27">30</xref>
                    </sup> To train the prediction function, K-fold separates all the observations into equal-sized groups of samples termed folds and k-1 folds. The fold that is left out is then used for testing k times repeatedly.
                    <sup>
                        <xref ref-type="bibr" rid="ref30">33</xref>
                    </sup> The average of the results calculated in the loop serves as the k-fold cross-validation performance measure.</p>
                <p>

                    <bold>Model selection:</bold> Appropriate models were selected for training after the data were prepared and split into training and testing sets. The task was a binary classifier because the outcome variable was categorical, and suitable classifiers needed to be chosen to make the prediction. Since modern contraceptive use was divided into two mutually exclusive categories (use or not use), the dataset employed in the analysis falls under the category of binary categorization. Hence, in this study, we used six widely used machine learning (ML) algorithms,
                    <sup>
                        <xref ref-type="bibr" rid="ref30">33</xref>
                    </sup> logistic regression (LR), random forest (RF), K-nearest neighbors (KNN), extreme gradient boosting (XGBoost), naive Bayes (NB), and support vector machines (SVMs), to predict determinants of modern contraceptive use among reproductive-age women in Ethiopia and compared the results of the traditional logistic regression model to the results of the best algorithm for identifying the new features influencing the outcome of interest.</p>
                <p>

                    <bold>Model training:</bold> The selected classifiers were trained using prepared data after model selection, and their performances were compared via tenfold cross-validation. Following this comparison, the top predictive model was chosen, and it was trained with balanced training data to make the final prediction on hypothetical test data.
                    <sup>
                        <xref ref-type="bibr" rid="ref30">33</xref>
                    </sup>
                </p>
                <p>

                    <bold>Model evaluation:</bold> Testing the model&#x2019;s performance on never-before-seen data that were set aside for this purpose during data splitting can help determine how well the model works after it has been trained. One popular technique for evaluating the effectiveness of a classification model is the confusion matrix, which is a straightforward cross-tabulation of the actual and predicted categories for the outcome variable. The performance criteria, which include the overall accuracy, precision, recall, and F1 score and were employed in this study to evaluate the effectiveness of the selected classifiers, can be calculated using confusion metrics. Additionally, the performance of the ML models was assessed using receiver operating characteristic (ROC) curves, and the value 0.5 = no discrimination. 0.5-0.7 = Poor discrimination. 0.7-0.8 = Acceptable discrimination. 0.8-0.9 = Excellent discrimination.
                    <sup>
                        <xref ref-type="bibr" rid="ref38">41</xref>
                    </sup>
                </p>
                <p>

                    <bold>Hyperparameter tuning:</bold> To better understand the possibility of obtaining the optimal values and avoid unnecessary computations for combinations of nonperforming parameters when searching for the optimal parameter settings. Grid search, random search, and Bayesian optimization were used to formulate hyperparameter optimization to improve the speed and quality of the learning process, and we attempted to incrementally adjust the parameters of our model to improve its performance.
                    <sup>
                        <xref ref-type="bibr" rid="ref39">42</xref>
                    </sup>
                </p>
                <p>

                    <bold>Making prediction:</bold> All the aforementioned activities occur in this stage, which is the last stage in machine learning methodology. By using independent variables as a framework, prediction involves estimating the outcome variable. In this instance, modern contraceptive use was established using crucial factors that were discovered along the route. The best-performing classifier with a specified accuracy was used to predict whether a woman would use modern contraceptive services given various factors. The overall workflow of the methodology is shown below (
                    <xref ref-type="fig" rid="f1">
Figure 1</xref>).</p>
                <fig fig-type="figure" id="f1" orientation="portrait" position="float">
                    <label>
Figure 1. </label>
                    <caption>
                        <title>Overview of methodologies.</title>
                    </caption>
                    <graphic id="gr1" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/191315/5a6ab554-70d8-440d-8485-ee932e63c010_figure1.gif"/>
                </fig>
            </sec>
        </sec>
        <sec id="sec12" sec-type="results">
            <title>Results</title>
            <sec id="sec13">
                <title>Socio-demographic and economic characteristics</title>
                <p>Most of the women (5177, 56.85%) were rural residents, and 5,326 (58.48%) were aged between 26 and 35 years. The majority of participants was poor (32.48%), had a primary education (54.34%) and had no media access (92.1%). Regarding the regional distribution of respondents, the majority of the women were from Oromia (19.44%), followed by the SNNPR (18.15%), and approximately 17.66% were from Amhara. The remaining regions accounted for 44.75% of the total study population (
                    <xref ref-type="table" rid="T2">
Table 2</xref>).</p>
                <table-wrap id="T2" orientation="portrait" position="float">
                    <label>
Table 2. </label>
                    <caption>
                        <title>Socio-demographic and economic characteristics of the respondents.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Variable</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Categories</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Weighted Freq.</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">
Percent (%)</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="2" valign="top">Residence</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Urban</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1,620</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">18.33</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Rural</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">7,217</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">81.67</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="2" valign="top">Marital status</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Married</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">5,624</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">63.64</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">single</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">3,213</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">36.36</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="3" valign="top">Women&#x2019;s age</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">15 to 25</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2,409</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">27.54</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">26 to 35</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">5,326</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">58.48</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">36 to 49</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1,273</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">13.98</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="11" valign="top">Region</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Tigray</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1,196</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">13.13</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Afar</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">424</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4.66</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Amhara</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1,608</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">17.66</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Oromia</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1,770</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">19.44</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Somali</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">194</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2.13</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Benishangul-Gumuz
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">289</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">3.17</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">SNNPR</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1,653</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">18.15</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Gambela</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">350</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">3.84</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Harari</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">342</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">3.76</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Addis</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">884</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">9.71</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Dire Dawa</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">397</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4.36</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="3" valign="top">Education level</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">No education</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">3,072</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">34.42</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Primary</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4,808</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">54.34</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">secondary and above</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1,003</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">11.24</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="3" valign="top">Wealth index</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Poor</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2,907</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">32.48</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Middle</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1,263</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">16.07</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Rich</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4,667</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">51.46</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="2" valign="top">Media access</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">No</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">7,916</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">89.5</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Yes</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">921</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">10.5</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
            </sec>
            <sec id="sec14">
                <title>Reproductive health and family planning use characteristics of the study participants</title>
                <p>Among the total respondents, 6,029 (67.55%) had a history of pregnancy, and approximately 4,769 (70.29%) had started sexual intercourse before the age of 18 years. Approximately 2,544 (43.64%) of the women had never delivered at health facilities. Regarding their partner/husband feelings toward FP use, the majority of the women (3,298; 58.41%) had approved the use of FPs by their husband/partner (
                    <xref ref-type="table" rid="T3">
Table 3</xref>).</p>
                <table-wrap id="T3" orientation="portrait" position="float">
                    <label>
Table 3. </label>
                    <caption>
                        <title>Reproductive health and family planning service characteristics of the respondents.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Variable</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Categories</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Weighted Freq.</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">
Percent</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="2" valign="top">Ever been pregnant</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">No</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2,836</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">32.45</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Yes</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">6,021</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">67.55</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="2" valign="top">Age at first sex</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Before age 18</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4,723</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">70.29</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">After age 18</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4,114</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">29.71</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="2" valign="top">Ever used FP methods</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">No</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4,306</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">49.19</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Yes</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">4,531</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">50.81</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="2" valign="top">Ever delivered in HF</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">No</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2,524</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">43.64</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Yes</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">3,313</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">56.36</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="2" valign="top">Partner/husband feeling about FP</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Disapproval</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2,626</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">41.59</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Approved</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">6,211</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">58.41</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="2" valign="top">Partner told not to use FP</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">No</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">6,505</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">73.61</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Yes</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2,332</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">26.39</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
            </sec>
            <sec id="sec15">
                <title>Modern contraceptive use</title>
                <p>Among the study participants, only 24% {95% CI (23.1%, 24.9%)} used modern contraceptive methods. Most (1,204, 13.6%) of the modern contraceptive users had a secondary education (
                    <xref ref-type="fig" rid="f2">
Figure 2</xref>).</p>
                <fig fig-type="figure" id="f2" orientation="portrait" position="float">
                    <label>
Figure 2. </label>
                    <caption>
                        <title>Modern contraceptive use among reproductive-age women in Ethiopia: Evidence from the Performance Monitoring and Accountability (PMA) Survey 2019 dataset.</title>
                    </caption>
                    <graphic id="gr2" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/191315/5a6ab554-70d8-440d-8485-ee932e63c010_figure2.gif"/>
                </fig>
            </sec>
            <sec id="sec16">
                <title>Machine learning analysis of modern contraceptive use among reproductive-age individuals in Ethiopia</title>
                <p>

                    <bold>Feature selection</bold>
                </p>
                <p>Feature selection is crucial for determining the most important predictors of an outcome variable, similar to how p values and t statistics are used in most traditional statistical methods, to determine which variables are significant. Accordingly, when using an ensemble model to predict an outcome, feature importance measures how significant a feature is on average concerning other features.</p>
                <p>The most significant predictors of modern contraceptive use according to the extreme gradient boost feature importance results were age at first family planning use (20 years and above), marital status (single), partner/husband feelings about family planning (Approval from partner) and relationship with the head of household (having a wife relationship to the head). In addition, age (36 to 49 years), health care providers advise about the use of FP methods during health facility visit, perception about the FP side effects might disrupt their relationship and household size (5 and above) were other key predictors. The length of the bars on the x-axis, which represents the relative significance of the independent variables in predicting the use of modern contraceptives, shows this. The longer the bar is, the more significant the trait is in determining whether a woman utilizes modern contraception (
                    <xref ref-type="fig" rid="f3">
Figure 3</xref>).</p>
                <fig fig-type="figure" id="f3" orientation="portrait" position="float">
                    <label>
Figure 3. </label>
                    <caption>
                        <title>Feature importance plot using the XGBoost model for predictors of modern contraceptive use in Ethiopia.</title>
                    </caption>
                    <graphic id="gr3" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/191315/5a6ab554-70d8-440d-8485-ee932e63c010_figure3.gif"/>
                </fig>
                <p>

                    <bold>Model selection</bold>
                </p>
                <p>After the data were prepared and divided into training and testing datasets, as indicated in 
                    <xref ref-type="table" rid="T4">
Table 4</xref>, the appropriate models were chosen for the training dataset. To predict the factors that influence the use of modern contraceptives among reproductive-age women in Ethiopia, we used six commonly used machine learning (ML) algorithms, namely, logistic regression (LR), random forest (RF), K-nearest neighbors (KNN), extreme gradient boosting (XGBoost), naive Bayes (NB), and support vector machines (SVMs). We chose the best model from among these machine learning approaches based on its higher level of accuracy (
                    <xref ref-type="table" rid="T4">
Table 4</xref>).</p>
                <table-wrap id="T4" orientation="portrait" position="float">
                    <label>
Table 4. </label>
                    <caption>
                        <title>Model accuracy metrics for all the models evaluated on the training data.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Algorithms</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Minimum</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">1st Quartile</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Median</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Mean</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">3rd Quartile</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">
Maximum</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Logistic Regression</bold>
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.788</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.798</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.802</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.801</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.804</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.809</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Random Forest</bold>
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.795</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.796</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.801</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.800</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.805</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.807</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>XGBoost</bold>
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.790</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.803</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.809</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.806</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.812</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.814</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>KNN</bold>
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.769</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.778</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.782</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.785</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.790</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.806</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Naive Bayes</bold>
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.758</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.793</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.799</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.797</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.807</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.814</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <bold>Linear SVM</bold>
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.792</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.796</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.797</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.800</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.806</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.811</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <p>A figure based on the mean level of accuracy serves as the representation for the summary models. The extreme gradient boost model therefore had the best model for training the dataset, with a mean accuracy of 80.6% (
                    <xref ref-type="fig" rid="f4">
Figure 4</xref>).</p>
                <fig fig-type="figure" id="f4" orientation="portrait" position="float">
                    <label>
Figure 4. </label>
                    <caption>
                        <title>Model accuracy metrics for all the models evaluated on the training data.</title>
                    </caption>
                    <graphic id="gr4" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/191315/5a6ab554-70d8-440d-8485-ee932e63c010_figure4.gif"/>
                </fig>
                <p>

                    <bold>Prediction of modern contraceptive use</bold>
                </p>
                <p>Using the remaining test data (predictions from unseen test data), the performance of the predictive models for predicting modern contraceptive use was compared using the mean accuracy and mean area under the curve (AUC) of the ML models in stratified tenfold cross-validation.</p>
                <p>After all the models were investigated in this study, extreme gradient boosting was found to have the greatest accuracy (81.97%, 95% CI{(79.06%, 82.7%)} as was the ROC area (76.63%), followed by logistic regression with minor difference (80.52%, 95% CI {(78.6%, 82.3%)} and support vector machines (SVMs) (80.41%), 95% CI{(78.48%, 82.2%)}.</p>
                <p>The XGBoost model had relatively low specificity (88.67%), which meant that it performed poorly in identifying predictors of modern contraceptive use in Ethiopia but had high sensitivity (66.6%), which meant that it was more accurate in identifying predictors of modern contraceptive use (
                    <xref ref-type="table" rid="T5">
Table 5</xref>).</p>
                <table-wrap id="T5" orientation="portrait" position="float">
                    <label>
Table 5. </label>
                    <caption>
                        <title>Model accuracy metrics for all the models evaluated on the test data.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="2" valign="top">Confusion matrix</th>
                                <th align="left" colspan="2" rowspan="1" valign="top">Logistic Regression</th>
                                <th align="left" colspan="2" rowspan="1" valign="top">Random Forest</th>
                                <th align="left" colspan="2" rowspan="1" valign="top">XG Boost</th>
                                <th align="left" colspan="2" rowspan="1" valign="top">KNN</th>
                                <th align="left" colspan="2" rowspan="1" valign="top">Naive Bayes</th>
                                <th align="left" colspan="2" rowspan="1" valign="top">SVM</th>
                            </tr>
                            <tr>
                                <th align="left" colspan="2" rowspan="1" valign="top">Observed</th>
                                <th align="left" colspan="2" rowspan="1" valign="top">Observed</th>
                                <th align="left" colspan="2" rowspan="1" valign="top">Observed</th>
                                <th align="left" colspan="2" rowspan="1" valign="top">Observed</th>
                                <th align="left" colspan="2" rowspan="1" valign="top">Observed</th>
                                <th align="left" colspan="2" rowspan="1" valign="top">Observed</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Predicted</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">No MCP use</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">MCP use</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">No MCP use</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">MCP use</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">No MCP use</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">MCP use</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">No MCP use</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">MCP use</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">No MCP use</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">MCP use</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">No MCP use</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
MCP use</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">No MCP use</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">
                                    <monospace>1179</monospace>
</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">181</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">1258</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">249</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">129</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">80</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">175</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">143</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">175</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">143</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">162</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">122</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">MCP use</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">163</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">243</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">84</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">175</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">233</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">494</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">187</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">431</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">187</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">431</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">200</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">452</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Metrics</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">%</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">%</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">%</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">%</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">%</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">%</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Accuracy</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">80.52</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">81.2</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">81.97</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">79.95</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">79.84</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">80.41</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">95% CI</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">(78.6, 82.3)</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">79.3, 83.0)</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">(79.06, 82.7)</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">(78.01, 81.8)</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">(77.89, 81.6)</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">(78.48, 82.2)</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Sensitivity</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">57.31</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">41.27</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">66.60</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">56.84</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">44.34</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">64.86</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Specificity</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">87.85</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">93.81</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">88.67</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">87.26</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">91.06</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">85.32</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Positive predictive value</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">59.85</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">67.83</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">61.22</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">58.50</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">61.04</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">58.26</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Negative predictive value</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">86.69</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">83.48</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">86.61</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">86.48</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">83.81</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">88.49</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">AUC</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">72.58</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">70.54</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">76.63</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">72.04</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">69.99</td>
                                <td align="left" colspan="2" rowspan="1" valign="top">75.08</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <p>Visualization of the receiver operating characteristic (ROC) curve was performed. Among the six machine learning models employed in this study, the curve of the extreme gradient boost model had the highest percentage of AUC values, indicating that it is the best at classifying the use or nonuse of modern contraceptive methods among reproductive-age women in Ethiopia. Moreover, this best model represented an acceptable range of AUC values (76.63%) (
                    <xref ref-type="fig" rid="f5">
Figure 5</xref>).</p>
                <fig fig-type="figure" id="f5" orientation="portrait" position="float">
                    <label>
Figure 5. </label>
                    <caption>
                        <title>Receiver operating characteristic (ROC) curve of the six models&#x2019; AUC percentages for comparison of model predictions on test data.</title>
                    </caption>
                    <graphic id="gr5" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/191315/5a6ab554-70d8-440d-8485-ee932e63c010_figure5.gif"/>
                </fig>
            </sec>
        </sec>
        <sec id="sec17" sec-type="discussion">
            <title>Discussion</title>
            <p>In this study, a weighted sample of 8837 women of reproductive age was employed for the final analysis, which was limited to secondary data from the PMA Ethiopia 2019 Cross-sectional Household and Female Survey. The use of modern contraceptive methods was found to be extremely low (24%),
                <sup>
                    <xref ref-type="bibr" rid="ref40">43</xref>
                </sup> which is comparable to the findings of earlier studies carried out in Ethiopia. These earlier studies revealed that the use of modern contraceptive methods was 31.7% in rural Dembia District, northwestern Ethiopia
                <sup>
                    <xref ref-type="bibr" rid="ref5">7</xref>
                </sup>; 11.0% in the surrounding Peasant Association of Gondar Town
                <sup>
                    <xref ref-type="bibr" rid="ref5">7</xref>
                </sup>; 38.3% in Mojo Town, southern Ethiopia
                <sup>
                    <xref ref-type="bibr" rid="ref41">44</xref>
                </sup>; and 67.4% in Hosanna.
                <sup>
                    <xref ref-type="bibr" rid="ref42">45</xref>
                </sup> The possible reason could be an increased expansion of government and private health institutions, including health posts, as well as the communication of information by health extension workers and various nongovernmental organizations (NGOs). The difference might also be due to differences in awareness of modern contraceptive methods.</p>
            <p>To identify determinants of modern contraceptive use, each algorithm was trained on 80% of the total instances through random sampling, and its effectiveness was tested on 20% of the total instances through random sampling. Six widely used machine learning (ML) algorithms, logistic regression (LR), random forest (RF), K-nearest neighbors (KNN), extreme gradient boosting (XGBoost), naive Bayes (NB), and support vector machines (SVMs), were included in the study to predict determinants of modern contraceptive use among reproductive-age women in Ethiopia.</p>
            <p>The performance of the predictive models in predicting determinants of modern contraceptive use was assessed using the remaining tested data (predictions from unseen test data) and compared against the mean accuracy and mean area under the curve (AUC) of the ML models in stratified tenfold cross-validation. Accordingly, extreme gradient boosting had the highest accuracy (81.97%), 95% CI (79.06%, 82.7%) and area under the ROC curve (76.63%). The performance of this model is much better than that of studies conducted on the prediction of contraceptive discontinuation among reproductive-age women in Ethiopia using the Ethiopian Demographic and Health Survey 2016 dataset. These studies used the random forest model as the best predictive model, with an accuracy of 68% and an ROC of 74% based on a tenfold cross-validation score on balanced training data
                <sup>
                    <xref ref-type="bibr" rid="ref43">46</xref>
                </sup>; additionally, another study conducted in Ethiopia also found the random forest model to be the best machine learning model for predicting nutritional status for children under five years of age using EDHS data, with an accuracy and AUC of 68.2% and 0.76, respectively.
                <sup>
                    <xref ref-type="bibr" rid="ref44">47</xref>
                </sup> These results, however, are lower than those of an Indonesian study in which AdaBoost was identified as the most accurate model for predicting the duration of contraceptive use, for which the accuracy was 85.1%. The size of the dataset used to develop the model may be the cause of this mismatch. The Indonesian study employed 39,594 records, whereas this study used only 8837 records, allowing the model to train more effectively and make predictions with greater accuracy.</p>
            <p>Specific characteristics related to the use of modern contraceptives in Ethiopia that can be used as intervention targets were compared, identified, and recognized with the aid of machine learning methods. The extreme gradient boosting (XGB) and support vector machine models have the highest prediction power among the constructed predictive models compared to other machine learning classifier models, such as the RF and KNN models. According to the extreme gradient boost feature importance results, the variables were age at first family planning use, marital status, partner/husband feelings about family planning and relationship with the head of household. In addition, age and health care providers spoke about FP methods at health facility visits; if I use FPs, side effects might disrupt my relationship, and household size is also an important predictor of modern contraceptive use. This study is roughly in line with previous findings.</p>
            <p>Age at first family planning use (20-30 years and above) was the first significant characteristic of modern contraceptive use among reproductive-age women in Ethiopia. This finding was consistent with that of a study performed in Bangladesh, southern Ethiopia, Nigeria, and the Democratic Republic of the Congo, which revealed that as women&#x2019;s age increased from 15 to 34, the likelihood that they would use contraceptives increased.
                <sup>
                    <xref ref-type="bibr" rid="ref46">48</xref>&#x2013;
                    <xref ref-type="bibr" rid="ref50">51</xref>
                </sup> The most likely explanation is that in rural settings, this age range is when most women are involved in various activities to take care of their household&#x2019;s requirements, leading them to wish to space their pregnancies. Therefore, they favor the use of contraceptive techniques. The other factor might be that people in this age group now have women&#x2019;s forum associations to debate the topic, as well as greater experience sharing from colleagues and neighbors. As a result, their utilization rate could increase. These results, however, did not align with research carried out in Mojo town,
                <sup>
                    <xref ref-type="bibr" rid="ref41">44</xref>
                </sup> and a study performed in Kerman,
                <sup>
                    <xref ref-type="bibr" rid="ref51">52</xref>
                </sup> Iran, revealed that people who used modern contraceptives had a younger mean age than people who did not. Differences in socio-demographic characteristics and durations may also explain the differences.</p>
            <p>The marital status of reproductive-age women in Ethiopia was one of the other most significant factors for predicting modern contraception use. This conclusion was consistent with the findings of studies conducted in Tanzania and Gondar, Ethiopia, which showed that married women were more likely to use modern contraceptives than unmarried (single, widowed, or divorced) women were.
                <sup>
                    <xref ref-type="bibr" rid="ref4">6</xref>,
                    <xref ref-type="bibr" rid="ref5">7</xref>
                </sup> The outcome highlights the significance of male involvement in reproductive health issues, such as fertility and contraception, as well as couples&#x2019; motivation through education. Counseling and FP education should encourage couples to share their fertility concerns with one another.</p>
            <p>Couples&#x2019; desire to have a/another child was also the most important feature of modern contraceptive use in predicting reproductive-age women in Ethiopia. This finding is consistent with the findings of studies conducted on predictors of modern contraceptive method use among married women of reproductive age in Western Ethiopia and elsewhere, which showed that those respondents who did not express future desire for children were 2.6 times more likely to utilize modern contraceptives during the study period.
                <sup>
                    <xref ref-type="bibr" rid="ref14">20</xref>,
                    <xref ref-type="bibr" rid="ref15">21</xref>
                </sup> It was obvious that women who desired children were not ready to use contraceptives.</p>
            <p>The most significant aspect of modern contraceptive use predictions among Ethiopian women of reproductive age was the partner/husband&#x2019;s attitude toward family planning. These findings are consistent with research conducted in Gondar, Ethiopia.
                <sup>
                    <xref ref-type="bibr" rid="ref5">7</xref>
                </sup> This may be attributable to the discussion that can lead to an appropriate decision regarding the selection and use of FP methods, and the fact that the discussion was present in rural areas suggested that there may be a high level of knowledge regarding FP methods.</p>
            <p>The most significant aspect of modern contraceptive use prediction was the discussion of FP techniques by healthcare personnel during health facility visits. This result is in line with the findings of other studies performed elsewhere that emphasize the need to promote contraceptive use after delivery by utilizing the prenatal period as a window of opportunity. Effective contraception counseling included in comprehensive ANC not only boosts client satisfaction and prenatal care quality but may also lead to an increase in postpartum contraceptive use.
                <sup>
                    <xref ref-type="bibr" rid="ref52">53</xref>,
                    <xref ref-type="bibr" rid="ref53">54</xref>
                </sup> There is evidence suggesting that health care workers could be trained/retrained to provide more effective FP services through group health education sessions, the distribution of simple educational material to postpartum FPs, individualized counseling and the initiation of chosen contraceptive methods.
                <sup>
                    <xref ref-type="bibr" rid="ref54">55</xref>,
                    <xref ref-type="bibr" rid="ref55">56</xref>
                </sup>
            </p>
            <sec id="sec18">
                <title>Limitations and strengths of the study</title>
                <p>

                    <list list-type="bullet">
                        <list-item>
                            <label>&#x2713;</label>
                            <p>A key limitation of this study is the regional imbalance of the sample, with majority of participants being from rural areas, which may limit the generalizability of the findings to more urban populations.</p>
                        </list-item>
                        <list-item>
                            <label>&#x2713;</label>
                            <p>Due to their black-box nature, supervised machine learning algorithms do not have coefficients such as odds ratios or incident rate ratios. Therefore, the strength and direction of associations are unknown, additionally absence of external validation and risk of over fitting are also the major limitation of this study.</p>
                        </list-item>
                        <list-item>
                            <label>&#x2713;</label>
                            <p>Moreover, the current study emphasized mothers-related attributes more. Fathers&#x2019;-related attributes, such as fathers&#x2019; education and income level, were missed; hence, future researchers recommend conducting similar studies by addressing the limitations of this study.</p>
                        </list-item>
                    </list>
                </p>
            </sec>
        </sec>
        <sec id="sec19">
            <title>Conclusion and Recommendations</title>
            <p>In this study, the utilization of modern contraceptive methods was found to be extremely low. Six widely accepted machine learning algorithms have been used to predict determinants of modern contraceptive use in Ethiopia. Different confusion matrices were used to compare the candidate supervised machine learning algorithms. Based on the predictive model result results, extreme gradient boosting (XGB) was the best performing model and age at first family planning use, marital status, partner/husband feelings about family planning and relationships with the head of household, women&#x2019;s age, having discussions with healthcare providers about FP methods at health facility visits, and household size were important predictors of modern contraceptive use. The use of modern contraceptives is therefore expected to increase with effective contraceptive counseling during ANC/PNC follow-up on family planning use and increasing partner discussions on FP. Enhancing contraceptive counseling techniques concerning the age at which family planning is used for the first time and the engagement of men in FP should also be investigated. It was also necessary to consider enabling women to choose their methods through spousal discussion and providing health information to modify traditional attitudes around the number of children, which was seen as beneficial for the family.</p>
            <p>Furthermore, Future study should employ causal inference designs (randomized controlled trials, longitudinal analyses, or quasi-experimental) to validate and clarify the predictive associations identified in this analysis and to check whether variable identified in this predictive result can causally influence contraceptive use.</p>
            <sec id="sec20">
                <title>Ethical approval and consent to participate</title>
                <p>Ethical clearance and consent was not necessary for this study since it was based on publicly available data sources. Permission to use the data was granted by the PMA Ethiopia&#x2019;s survey project through legal registration.</p>
            </sec>
        </sec>
        <sec id="sec21">
            <title>Consent for publication</title>
            <p>Not applicable.</p>
        </sec>
        <sec id="sec22">
            <title>Patient and public participation</title>
            <p>Not applicable.</p>
        </sec>
        <sec id="sec23">
            <title>Author&#x2019;s contributions</title>
            <p>JBA, Conceived and designed the study; analysis, interpreted the result and wrote the paper. AAA, SDK, ADW and DNM made significant contributions to the work reported; contributed to the acquisition of data, contributed to all these areas; participated in drafting, revising or critically reviewing the article; and agreed to be accountable for all aspects of the work. All the authors read and approved the final manuscript.</p>
        </sec>
    </body>
    <back>
        <sec id="sec26" sec-type="data-availability">
            <title>Data availability</title>
            <p>The datasets analyzed in the current study are available in the Performance Monitoring for Action repository, 
                <ext-link ext-link-type="uri" xlink:href="https://www.pmadata.org/data/request-access-datasets">https://www.pmadata.org/data/request-access-datasets</ext-link>. The full datasets analysed in the current study are available in the Performance Monitoring for Action (PMA) Ethiopia cross-sectional household and women&#x2019;s survey. (DOI: 
                <ext-link ext-link-type="uri" xlink:href="https://www.pmadata.org/data/request-access-datasets">https://www.pmadata.org/data/request-access-datasets</ext-link>).</p>
            <p>The project comprises three key components: annual cross-sectional surveys of women aged 15&#x2013;49, longitudinal studies tracking pregnant women and new mothers, and yearly service delivery point surveys assessing health facilities.</p>
            <p>Data are available under the terms of the 
                <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International license</ext-link> (CC-BY 4.0).</p>
        </sec>
        <ack>
            <title>Acknowledgments</title>
            <p>We would like to express our deepest appreciation to the PMA for permitting data access for this study.</p>
        </ack>
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    <sub-article article-type="reviewer-report" id="report438239">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.191315.r438239</article-id>
            <title-group>
                <article-title>Reviewer response for version 2</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>M&#x00fc;ller</surname>
                        <given-names>Nora</given-names>
                    </name>
                    <xref ref-type="aff" rid="r438239a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-0756-0188</uri>
                </contrib>
                <contrib contrib-type="author">
                    <name>
                        <surname>Chan</surname>
                        <given-names>Hao-Ting</given-names>
                    </name>
                    <xref ref-type="aff" rid="r438239a2">2</xref>
                    <role>Co-referee</role>
                </contrib>
                <aff id="r438239a1">
                    <label>1</label>DRS, GESIS &#x2013;Leibniz-Institute for the Social Sciences, Mannheim, Mannheim, Germany</aff>
                <aff id="r438239a2">
                    <label>2</label>CSS, GESIS - Leibniz Institute for the Social Sciences Cologne (Ringgold ID: 28363), Cologne, North Rhine-Westphalia, Germany</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>16</day>
                <month>1</month>
                <year>2026</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2026 M&#x00fc;ller N and Chan HT</copyright-statement>
                <copyright-year>2026</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport438239" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.156316.2"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>
                <bold>Review</bold>
            </p>
            <p> 
                <bold>F1000 Research</bold>
            </p>
            <p> 
                <underline>Title of reviewed paper (R1): </underline>
            </p>
            <p> 
                <italic>Predicting determinants of modern contraceptive use among reproductive-age women in Ethiopia using machine learning algorithms: Evidence from the Performance Monitoring and Accountability (PMA) Survey 2019 dataset</italic>
            </p>
            <p> 
                <bold>Overall evaluation</bold>
            </p>
            <p> The manuscript addresses an important topic &#x2014; modern contraceptive use among reproductive-age women in Ethiopia &#x2014; using data from the 2019 PMA survey and a set of supervised machine learning (ML) algorithms. While the revised version improves clarity in some methodological aspects compared to version 1, substantial conceptual and analytical weaknesses remain. Most importantly, the manuscript does not clearly articulate a research gap or a concrete scientific contribution, and it overstates the advantages of machine learning without sufficiently demonstrating them in the empirical analysis.</p>
            <p> At present, the paper reads more as an application of standard ML techniques to a well-studied outcome rather than as a contribution that advances theory, methodology, or substantive knowledge in a clearly defined way.</p>
            <p> 
                <bold>Major comments</bold> 
                <list list-type="order">
                    <list-item>
                        <p>
                            <italic>No Clearly Identified Research Gap</italic>
                        </p>
                    </list-item>
                </list> The manuscript does not clearly identify or articulate a specific research gap. While the introduction repeatedly claims limitations of &#x201c;traditional regression models&#x201d; and motivates the use of machine learning, this motivation remains generic and underdeveloped. It is not made explicit: 
                <list list-type="bullet">
                    <list-item>
                        <p>what is missing in the existing literature on modern contraceptive use,</p>
                    </list-item>
                    <list-item>
                        <p>why existing regression-based studies are insufficient for the research question at hand,</p>
                    </list-item>
                    <list-item>
                        <p>or what new knowledge the present study aims to generate beyond prior findings.</p>
                    </list-item>
                </list> 
                <italic>Suggestions:</italic>
            </p>
            <p> The authors should explicitly state a research gap (or gaps) early in the introduction and explain how the chosen design and methods are intended to address it. 
                <list list-type="order">
                    <list-item>
                        <p>
                            <italic>No Clearly Stated Contribution</italic>
                        </p>
                    </list-item>
                </list> Relatedly, the manuscript does not clearly state its scientific contribution. The identified predictors (e.g., partner approval, age, counseling by health workers, household size) are well-established in the existing literature on contraceptive use in Ethiopia and other Sub-Saharan African contexts. Thus, the contribution cannot lie in the discovery of new determinants.</p>
            <p> At present, it remains unclear whether the intended contribution is: 
                <list list-type="bullet">
                    <list-item>
                        <p>methodological (demonstrating the usefulness of ML),</p>
                    </list-item>
                    <list-item>
                        <p>applied (supporting program targeting or risk profiling),</p>
                    </list-item>
                    <list-item>
                        <p>or purely comparative (benchmarking different algorithms).</p>
                    </list-item>
                </list> Without explicitly stating this, the manuscript risks overstating its novelty.</p>
            <p> 
                <italic>Suggestions:</italic>
            </p>
            <p> The authors should clearly articulate what the paper contributes beyond prior studies and explicitly acknowledge that the contribution is predictive and applied, rather than causal or theoretical. 
                <list list-type="order">
                    <list-item>
                        <p>
                            <italic>Weak Justification for the Use of Machine Learning</italic>
                        </p>
                    </list-item>
                </list> The arguments provided for the advantages of machine learning over traditional regression models remain weak and largely rhetorical: 
                <list list-type="bullet">
                    <list-item>
                        <p>Partially False: &#x201c;&#x2026;Logistic regressions, assume linear relationships...&#x201d;. LR does not assume a linear relationship between the outcome and predictors. Rather, it assumes a linear relationship on the logit scale (the log-odds scale). (Hosmer et al. 1989; Yay 2023)</p>
                    </list-item>
                    <list-item>
                        <p>Misleading: &#x201c;&#x2026;ML algorithms can efficiently handle nonlinear associations, multicollinearity&#x2026;&#x201d;. ML face the same challenge, they struggle with multicollinearity, though some handle it differently through regularization or feature selection methods. Both LR and ML learning approaches implement techniques to address correlated predictors. (Levy and O&#x2019;Malley 2020)</p>
                    </list-item>
                    <list-item>
                        <p>Empirical inconsistency: As shown in Figure 4, logistic regression is the second best performing model, with an accuracy difference of only 0.5 compared with the top performing model. This marginal improvement does not provide strong empirical support for favoring machine learning approaches, particularly given their increased complexity and reduced interpretability.</p>
                    </list-item>
                </list> Claims regarding nonlinear relationships, multicollinearity, and higher-order interactions are stated, but not convincingly demonstrated or exploited in the analysis.</p>
            <p> In contrast to stronger methodological discussions in recent literature, the manuscript does not explain: 
                <list list-type="bullet">
                    <list-item>
                        <p>which specific limitations of logistic regression are most relevant in this context,</p>
                    </list-item>
                    <list-item>
                        <p>why these limitations are substantively important for understanding contraceptive use,</p>
                    </list-item>
                    <list-item>
                        <p>or how ML meaningfully overcomes them in practice.</p>
                    </list-item>
                </list> 
                <italic>Suggestions:</italic>
            </p>
            <p> The justification for ML should be strengthened and made more concrete, or alternatively, the claims regarding its superiority should be substantially toned down. See Sun (2024) for valuable arguments for the advantages of ML models in explorative studies. 
                <list list-type="order">
                    <list-item>
                        <p>
                            <italic>Claimed Ability to Capture Interactions Is Not Empirically Used</italic>
                        </p>
                    </list-item>
                </list> One of the main stated advantages of machine learning models is their ability to automatically capture interaction effects. However, the manuscript does not actually examine or interpret any interactions, nor does it attempt to show that interactions play a meaningful role in prediction.</p>
            <p> This raises a critical question: If interactions are a key justification for ML, why are they neither explored nor discussed?</p>
            <p> 
                <italic>Suggestion: </italic>
            </p>
            <p> The authors should either: 
                <list list-type="bullet">
                    <list-item>
                        <p>explicitly analyze and interpret interaction structures (e.g., via SHAP interaction values or partial dependence plots), or</p>
                    </list-item>
                    <list-item>
                        <p>refrain from presenting interaction modeling as a key advantage of their approach.</p>
                    </list-item>
                </list> &#x00a0; 
                <list list-type="order">
                    <list-item>
                        <p>
                            <italic>Outcome Prevalence and Model Evaluation</italic>
                        </p>
                    </list-item>
                </list> Modern contraceptive use has a relatively low prevalence (24%), resulting in a pronounced class imbalance. In such a setting, overall accuracy is a limited and potentially misleading performance metric.</p>
            <p> Although sensitivity and specificity are reported, the evaluation would benefit from: 
                <list list-type="bullet">
                    <list-item>
                        <p>balanced accuracy,</p>
                    </list-item>
                    <list-item>
                        <p>precision &#x2013; recall curves or PR-AUC,</p>
                    </list-item>
                    <list-item>
                        <p>F1 score, a harmonic mean of precision and recall</p>
                    </list-item>
                    <list-item>
                        <p>and calibration measures.</p>
                    </list-item>
                </list> This is particularly important given the policy-oriented interpretation of the findings. 
                <list list-type="order">
                    <list-item>
                        <p>
                            <italic>Inconsistent Interpretation of &#x201c;Most Important&#x201d; Predictors</italic>
                        </p>
                    </list-item>
                </list> The discussion contains internally inconsistent statements about which predictors are most important: On page 15, the manuscript states that &#x201c;the most significant aspect of modern contraceptive use predictions &#x2026; was the partner/husband&#x2019;s attitude toward family planning.&#x201d; On page 16, it states that &#x201c;the most significant aspect &#x2026; was the discussion of FP techniques by healthcare personnel during health facility visits.&#x201d;</p>
            <p> It is unclear how &#x201c;most significant&#x201d; is defined here and on what basis these claims are made.</p>
            <p> 
                <italic>Suggestions:</italic>
            </p>
            <p> If relative importance is central to the contribution, it should be quantified and presented systematically. In this regard, SHAP values or permutation-based importance measures would be highly appropriate, as they allow for transparent comparison of predictor contributions and improve interpretability.</p>
            <p> &#x00a0; 
                <list list-type="order">
                    <list-item>
                        <p>
                            <italic>Feature Importance Visualization and Labeling (Figure 3)</italic>
                        </p>
                    </list-item>
                </list> Figure 3 suffers from several issues: 
                <list list-type="bullet">
                    <list-item>
                        <p>The labeling is difficult to read and not self-explanatory.</p>
                    </list-item>
                    <list-item>
                        <p>Two age-related variables appear at the top of the importance ranking, but their conceptual distinction is not discussed.</p>
                    </list-item>
                    <list-item>
                        <p>The figure does not allow the reader to clearly assess relative importance across predictors.</p>
                    </list-item>
                </list> 
                <italic>Suggestions:</italic>
            </p>
            <p> Improve the readability and interpretability of Figure 3 (clear labels, consistent naming, possibly grouping related variables). A SHAP summary plot would substantially improve clarity.</p>
            <p> </p>
            <p> 
                <bold>Minor comments</bold> 
                <list list-type="bullet">
                    <list-item>
                        <p>Statements referring to model &#x201c;specificity&#x201d; as being &#x201c;low&#x201d; despite values around 88% are confusing and conceptually inaccurate.</p>
                    </list-item>
                    <list-item>
                        <p>The language occasionally reverts to causal phrasing (&#x201c;expected to increase&#x201d;), which should be avoided in a predictive study.</p>
                    </list-item>
                    <list-item>
                        <p>Software environments and package versions should be reported consistently.</p>
                    </list-item>
                </list> 
                <bold>References</bold>
            </p>
            <p> refer reference no. 1, 2, &amp; 3</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Partly</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Partly</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Partly</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Partly</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Reviewer Expertise:</p>
            <p>family sociology, machine-learning, contraceptive behavior</p>
            <p>We confirm that we have read this submission and believe that we have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however we have significant reservations, as outlined above.</p>
        </body>
        <back>
            <ref-list>
                <title>References</title>
                <ref id="rep-ref-438239-1">
                    <label>1</label>
                    <mixed-citation publication-type="journal">
                        <person-group person-group-type="author"/>:
                        <article-title>Don&#x2019;t dismiss logistic regression: the case for sensible extraction of interactions in the era of machine learning</article-title>.
                        <source>
                            <italic>BMC Medical Research Methodology</italic>
                        </source>.<year>2020</year>;<volume>20</volume>(<issue>1</issue>) :
                        <elocation-id>10.1186/s12874-020-01046-3</elocation-id>
                        <pub-id pub-id-type="doi">10.1186/s12874-020-01046-3</pub-id>
                    </mixed-citation>
                </ref>
                <ref id="rep-ref-438239-2">
                    <label>2</label>
                    <mixed-citation publication-type="journal">
                        <person-group person-group-type="author"/>:
                        <article-title>Assessment of the factors that affect fast-track or early extubation following pediatric cardiac surgery: Logistic regression in clinical studies</article-title>.
                        <source>
                            <italic>Turkish Journal of Thoracic and Cardiovascular Surgery</italic>
                        </source>.<year>2023</year>;<volume>31</volume>(<issue>1</issue>) :
                        <elocation-id>10.5606/tgkdc.dergisi.2023.98550</elocation-id>
                        <fpage>8</fpage>-<lpage>10</lpage>
                        <pub-id pub-id-type="doi">10.5606/tgkdc.dergisi.2023.98550</pub-id>
                    </mixed-citation>
                </ref>
                <ref id="rep-ref-438239-3">
                    <label>3</label>
                    <mixed-citation publication-type="journal">
                        <person-group person-group-type="author"/>:
                        <article-title>Supervised machine learning for exploratory analysis in family research</article-title>.
                        <source>
                            <italic>Journal of Marriage and Family</italic>
                        </source>.<year>2024</year>;<volume>86</volume>(<issue>5</issue>) :
                        <elocation-id>10.1111/jomf.12973</elocation-id>
                        <fpage>1468</fpage>-<lpage>1494</lpage>
                        <pub-id pub-id-type="doi">10.1111/jomf.12973</pub-id>
                    </mixed-citation>
                </ref>
            </ref-list>
        </back>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report436929">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.191315.r436929</article-id>
            <title-group>
                <article-title>Reviewer response for version 2</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Olisaeloka</surname>
                        <given-names>Lotenna</given-names>
                    </name>
                    <xref ref-type="aff" rid="r436929a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0001-9131-0036</uri>
                </contrib>
                <aff id="r436929a1">
                    <label>1</label>The University of British Columbia, Vancouver, British Columbia, Canada</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>8</day>
                <month>12</month>
                <year>2025</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2025 Olisaeloka L</copyright-statement>
                <copyright-year>2025</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport436929" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.156316.2"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>I now approve the revised version.</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Yes</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Partly</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Partly</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Reviewer Expertise:</p>
            <p>NA</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.</p>
        </body>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report415900">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.171606.r415900</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Olisaeloka</surname>
                        <given-names>Lotenna</given-names>
                    </name>
                    <xref ref-type="aff" rid="r415900a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0001-9131-0036</uri>
                </contrib>
                <aff id="r415900a1">
                    <label>1</label>The University of British Columbia, Vancouver, British Columbia, Canada</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>5</day>
                <month>11</month>
                <year>2025</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2025 Olisaeloka L</copyright-statement>
                <copyright-year>2025</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport415900" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.156316.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>Summary of the Article</p>
            <p> The manuscript analyzes data from the 2019 Performance Monitoring and Accountability (PMA) survey to identify predictors of modern contraceptive use among Ethiopian women of reproductive age. Using a weighted sample of 8,837 participants, the authors applied six supervised machine-learning algorithms and compared their predictive accuracy.</p>
            <p> XGBoost reportedly achieved the highest performance (accuracy of approx. 82% and AUC of 0.77). The authors conclude that age at first family-planning use, marital status, partner approval, women&#x2019;s age, household size, and health-provider counseling were the strongest predictors of contraceptive use. The authors recommend improving contraceptive counseling and fostering partner communication to increase modern contraceptive uptake.&#x00a0;</p>
            <p> The topic is very relevant to reproductive health in low-resource settings, especially Sub-Saharan Africa, and applying ML methods represents an advanced analytical approach. However, several issues concerning conceptual framing/scope, methodology, and interpretation must be addressed to improve the rigor and presentation of this paper.&#x00a0;</p>
            <p> 1. Clarity and Literature Grounding</p>
            <p> The article is generally readable and references pertinent literature, but several statements need clarification or correction for accuracy:&#x00a0; 
                <list list-type="order">
                    <list-item>
                        <p>Quantitative claims such as &#x201c;308 million unwanted pregnancies saved&#x201d; are ambiguous and lack a clearly defined time frame and source context. Consider rephrasing and using well-supported, up-to-date references to enhance the credibility of your argument.&#x00a0;</p>
                    </list-item>
                    <list-item>
                        <p>The paper would benefit from the inclusion of a definition for &#x201c;modern contraceptives&#x201d; (with examples) to help delineate the study scope.&#x00a0;</p>
                    </list-item>
                    <list-item>
                        <p>&#x00a0;Some background paragraphs mix causes of low contraceptive use with consequences (e.g., high fertility, maternal mortality). Reordering and clearer transitions would improve flow and logic.&#x00a0;</p>
                    </list-item>
                    <list-item>
                        <p>The rationale for adopting ML instead of traditional regression models is underdeveloped. Furthermore, the phrase &#x201c;problems involving multidisciplinary relationships between variables and many factors&#x201d; is quite unclear in the sentence context. Consider explaining the analytical challenges (e.g., nonlinearities, multicollinearity, interaction effects) that ML was expected to handle.&#x00a0;</p>
                    </list-item>
                    <list-item>
                        <p>Explain all abbreviations (e.g. KNN) on the first use and include them all in the abbreviation list.&#x00a0;</p>
                    </list-item>
                </list> </p>
            <p> 2. Study Design and Data Description</p>
            <p> Using PMA-Ethiopia data is appropriate, but the paper omits crucial methodological details that affect validity and reproducibility: 
                <list list-type="order">
                    <list-item>
                        <p>Sampling methodology: While the study mentions weighting, it does not sufficiently explain the PMA survey design and whether stratification or clustering were incorporated and accounted for. Indicating these would help readers better understand the survey&#x2019;s sampling procedure, how weights were applied, and help confirm national representativeness.&#x00a0;</p>
                    </list-item>
                    <list-item>
                        <p>Inclusion/exclusion criteria: The process by which the final analytical sample was derived is unclear. Please specify which respondents were included and which were excluded if any, from the initial sample. A simple participant-flow diagram could help clarify this.&#x00a0;</p>
                    </list-item>
                    <list-item>
                        <p>Operationalization of variables: For the predictor variable, please define what constructs (such as wealth index and media access) mean or how they were derived from the survey. For the outcome variable, also clarify whether &#x201c;modern contraceptive use&#x201d; refers to current or ever use, and how the dichotomous variable was generated from PMA items.&#x00a0;</p>
                    </list-item>
                </list> 3. Data Processing and Analytical Methods 
                <list list-type="order">
                    <list-item>
                        <p>The manuscript alternates between using Python (in Google Colab) and R with caret package for data analysis. For transparency and reproducibility purposes, clearly specify which environment and packages were actually used.&#x00a0;</p>
                    </list-item>
                    <list-item>
                        <p>The description of feature selection and dimensionality reduction process appear too general. Consider identifying the exact technique (e.g., information gain, recursive feature elimination) and justifying its choice.</p>
                    </list-item>
                    <list-item>
                        <p>Handling of missing data: There was no discussion of missing data in the survey and how it was handled.&#x00a0;&#x00a0;</p>
                    </list-item>
                </list> 4. Results and Statistical Interpretation 
                <list list-type="order">
                    <list-item>
                        <p>The descriptive statistics are clear, but the urban&#x2013;rural and regional imbalance of the sample (82% rural) may reflect issues with the survey/sampling technique and could limit result generalizability.&#x00a0;</p>
                    </list-item>
                    <list-item>
                        <p>The feature-importance plot (Figure 3) uses coded variable names that are difficult to interpret. Consider replacing with plain-language labels.&#x00a0;</p>
                    </list-item>
                    <list-item>
                        <p>Minor differences in accuracy across algorithms (&#x2248; 80&#x2013;82%) suggest limited added value of ML over logistic regression, which should be acknowledged.&#x00a0;</p>
                    </list-item>
                </list> 5. Discussion and Conclusions</p>
            <p> The discussion appropriately references comparable studies but often blurs the distinction between prediction and causation. Statements implying that identified features determine contraceptive use are not supported by a predictive design. Interpretations such as &#x201c;use is therefore expected to increase with counseling and partner discussion&#x201d; require caution as they are policy implications, not model findings. Instead, consider framing results as predictive associations that may inform hypothesis generation for future causal research.&#x00a0;</p>
            <p> Regional and contextual explanations are underdeveloped. For instance, large urban&#x2013;rural and regional disparities in contraceptive use could have been better discussed in relation to service availability or sociocultural norms.&#x00a0;</p>
            <p> The limitations section acknowledges the &#x201c;black-box&#x201d; nature of ML but should also consider the absence of external validation and risk of overfitting.</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Yes</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Partly</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Partly</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Reviewer Expertise:</p>
            <p>Public Health, Global Health, Digital Health, Artificial Intelligence.</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
        <back>
            <ref-list>
                <title>References</title>
                <ref id="rep-ref-415900-1">
                    <label>1</label>
                    <mixed-citation>
                        <article-title>Adem JB, Kebede SD, Walle AD and Mamo DN. Predicting determinants of modern contraceptive use among reproductive-age women in Ethiopia using machine learning algorithm: Evidence from the Performance Monitoring and Accountability (PMA) Survey 2019 dataset [version 1; peer review: 1 approved]. F1000Research 2025, 14:99 (https://doi.org/10.12688/f1000research.156316.1)</article-title>.</mixed-citation>
                </ref>
            </ref-list>
        </back>
        <sub-article article-type="response" id="comment14937-415900">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Adem</surname>
                            <given-names>Jibril Bashir</given-names>
                        </name>
                        <aff>Public Health, Arsi University, Asella, Oromia, Ethiopia</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>N/A</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>12</day>
                    <month>11</month>
                    <year>2025</year>
                </pub-date>
            </front-stub>
            <body>
                <p>
                    <bold>Summary of the Article</bold>
                </p>
                <p> This manuscript analyzes data from the 2019 Performance Monitoring and Accountability (PMA) survey to identify predictors of modern contraceptive use among Ethiopian women of reproductive age. Using a weighted sample of 8,837 participants, the authors applied six supervised machine-learning algorithms and compared their predictive accuracy.</p>
                <p> XGBoost reportedly achieved the highest performance (accuracy of approx. 82% and AUC of 0.77). The authors conclude that age at first family-planning use, marital status, partner approval, women&#x2019;s age, household size, and health-provider counseling were the strongest predictors of contraceptive use. The authors recommend improving contraceptive counseling and fostering partner communication to increase modern contraceptive uptake.</p>
                <p> The topic is very relevant to reproductive health in low-resource settings, especially Sub-Saharan Africa, and applying ML methods represents an advanced analytical approach. However, several issues concerning conceptual framing/scope, methodology, and interpretation must be addressed to improve the rigor and presentation of this paper.</p>
                <p> 
                    <bold>1. Clarity and Literature Grounding</bold>
                </p>
                <p> The article is generally readable and references pertinent literature, but several statements need clarification or correction for accuracy: 
                    <list list-type="bullet">
                        <list-item>
                            <p>Quantitative claims such as &#x201c;308 million unwanted pregnancies saved&#x201d; are ambiguous and lack a clearly defined time frame and source context. Consider rephrasing and using well-supported, up-to-date references to enhance the credibility of your argument.</p>
                        </list-item>
                    </list> 
                    <bold>Author response: </bold>Thank you very much for this comment; we revised the sentence to improve its clarity. 
                    <list list-type="bullet">
                        <list-item>
                            <p>The paper would benefit from the inclusion of a definition for &#x201c;modern contraceptives&#x201d; (with examples) to help delineate the study scope.</p>
                        </list-item>
                    </list> 
                    <bold>Author response: </bold>We included the definition and overview of modern contraceptives in the manuscript. Thank you 
                    <list list-type="bullet">
                        <list-item>
                            <p>Some background paragraphs mix causes of low contraceptive use with consequences (e.g., high fertility, maternal mortality). Reordering and clearer transitions would improve flow and logic.</p>
                        </list-item>
                    </list> 
                    <bold>Author response: </bold>We revised the sentences about the advantages of effective modern contraceptive utilization for improving maternal mortality, focusing on reordering and clearer transitions. Thank you</p>
                <p> &#x00a0; 
                    <list list-type="bullet">
                        <list-item>
                            <p>The rationale for adopting ML instead of traditional regression models is underdeveloped. Furthermore, the phrase &#x201c;problems involving multidisciplinary relationships between variables and many factors&#x201d; is quite unclear in the sentence context. Consider explaining the analytical challenges (e.g., nonlinearities, multicollinearity, interaction effects) that ML was expected to handle.</p>
                        </list-item>
                    </list> 
                    <bold>Author response: </bold>We revised the manuscript by integrating your important suggestions about explaining the analytical challenges (e.g., nonlinearities, multicollinearity, interaction effects) that ML was expected to handle. Thank you</p>
                <p> 5. Explain all abbreviations (e.g., KNN) on the first use and include them all in the abbreviation list.</p>
                <p> 
                    <bold>Author response: </bold>We included an explanation of each word's first abbreviation throughout the text. Thank you</p>
                <p> 
                    <bold>2. Study Design and Data Description</bold>
                </p>
                <p> Using PMA-Ethiopia data is appropriate, but the paper omits crucial methodological details that affect validity and reproducibility: 
                    <list list-type="bullet">
                        <list-item>
                            <p>Sampling methodology: While the study mentions weighting, it does not sufficiently explain the PMA survey design and whether stratification or clustering was incorporated and accounted for. Indicating these would help readers better understand the survey&#x2019;s sampling procedures and how weights were applied, and help confirm national representativeness.</p>
                        </list-item>
                    </list> 
                    <bold>Author response: </bold>We included a detailed description of the survey, including design and stratification/clustering-related information, in the manuscript. Thank you 
                    <list list-type="bullet">
                        <list-item>
                            <p>Inclusion/exclusion criteria: The process by which the final analytical sample was derived is unclear. Please specify which respondents were included and which were excluded, if any, from the initial sample. A simple participant-flow diagram could help clarify this.</p>
                        </list-item>
                    </list> 
                    <bold>Author response: </bold>We revised the manuscript by including the inclusion and exclusion criteria of the study. Thank you 
                    <list list-type="bullet">
                        <list-item>
                            <p>Operationalization of variables: For the predictor variable, please define what constructs (such as wealth index and media access) mean or how they were derived from the survey. For the outcome variable, also clarify whether &#x201c;modern contraceptive use&#x201d; refers to current or ever use, and how the dichotomous variable was generated from PMA items.</p>
                        </list-item>
                    </list> 
                    <bold>Author response: </bold>We included a definition and measurements of outcome and predictor variables of the study in the revised manuscript. Thank you</p>
                <p> 3. 
                    <bold>Data Processing and Analytical Methods</bold>
                </p>
                <p> 1. The manuscript alternates between using Python (in Google Collab) and R with the caret package for data analysis. For transparency and reproducibility purposes, clearly specify which environment and packages were used.</p>
                <p> 
                    <bold>Author response: </bold>We revised the sentence to indicate the use of R software version 4.4.3 for variable extraction and imputation and Python 3.11 for building machine learning (ML) algorithms. Thank you</p>
                <p> 2. The description of the feature selection and dimensionality reduction process appears too general. Consider identifying the exact technique (e.g., information gain, recursive feature elimination) and justifying its choice.</p>
                <p> 
                    <bold>Author response: </bold>We have included the use of recursive feature elimination and its justification in the revised manuscript. Thank you 
                    <list list-type="order">
                        <list-item>
                            <p>Handling of missing data: There was no discussion of missing data in the survey and how it was handled.&#x00a0;</p>
                        </list-item>
                    </list> 
                    <bold>Author response: </bold>We have included detailed explanations of the missing data handling method with its justifications in the revised manuscript. Thank you</p>
                <p> 
                    <bold>4. Results and Statistical Interpretation</bold>
                </p>
                <p> 1.&#x00a0;&#x00a0;&#x00a0;&#x00a0;&#x00a0;&#x00a0;&#x00a0;&#x00a0; The descriptive statistics are clear, but the urban&#x2013;rural and regional imbalance of the sample (82% rural) may reflect issues with the survey/sampling technique and could limit the results&#x2019; generalizability.</p>
                <p> 
                    <bold>Author response: </bold>We included the regional imbalance of the sample and its impact on the generalizability of the findings as a key limitation of this study in the limitations section. Thank you</p>
                <p> 2. The feature-importance plot (Figure 3) uses coded variable names that are difficult to interpret. Consider replacing them with plain-language labels.</p>
                <p> 
                    <bold>Author response: </bold>We have removed the coded variable, as the variable's description was already indicated in Table 1. Thank you</p>
                <p> 3. Minor differences in accuracy across algorithms (&#x2248; 80&#x2013;82%) suggest limited added value of ML over logistic regression, which should be acknowledged.</p>
                <p> 
                    <bold>Author response: </bold>We acknowledged the minor difference between the two models in the revised manuscript. Thank you</p>
                <p> </p>
                <p> 
                    <bold>5. Discussion and Conclusions</bold>
                </p>
                <p> 1. The discussion appropriately references comparable studies but often blurs the distinction between prediction and causation. Statements implying that identifiable features determine contraceptive use are not supported by a predictive design. Interpretations such as &#x201c;use is therefore expected to increase with counseling and partner discussion&#x201d; require caution, as they have policy implications, not model findings. Instead, consider framing results as predictive associations that may inform hypothesis generation for future causal research.</p>
                <p> 
                    <bold>Author response: </bold>We indicated the point that the results of this study are predictive association, rather than causal association, in the revised manuscript. Thank you</p>
                <p> 2. Regional and contextual explanations are underdeveloped. For instance, large urban&#x2013;rural and regional disparities in contraceptive use could have been better discussed in relation to service availability or sociocultural norms.</p>
                <p> 
                    <bold>Author response: </bold>Regional disparity of the participants was not found to be among the most important predictors by the model; thus, we are unable to discuss it in relation to service availability or sociocultural norms. However, specific personal characteristics like religion and educational level were found to be the most important, and they were discussed accordingly. Thank you</p>
                <p> 3. The limitations section acknowledges the &#x201c;black-box&#x201d; nature of ML but should also consider the absence of external validation and risk of overfitting.</p>
                <p> 
                    <bold>Author response: </bold>We revised the limitation section by indicating the absence of external validation and risk of overfitting and sample imbalance of the participants in terms of residence areas in the revised manuscript. Thank you</p>
            </body>
        </sub-article>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report367453">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.171606.r367453</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Sowunmi</surname>
                        <given-names>Christiana Olanrewaju</given-names>
                    </name>
                    <xref ref-type="aff" rid="r367453a1">1</xref>
                    <role>Referee</role>
                </contrib>
                <aff id="r367453a1">
                    <label>1</label>Babcock University, Ilishan-Remo, Ogun State, Nigeria</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>2</day>
                <month>4</month>
                <year>2025</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2025 Sowunmi CO</copyright-statement>
                <copyright-year>2025</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport367453" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.156316.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>The study explored an important area constituting reproductive health disease burden especially in sub-Saharan Africa. Given that the contraceptive prevalence (CPR) is low in African countries offers credit to this investigation on identifying factors relating to the problem. Identified major determinants by the authors resonate other studies on MCs&#x2019; use not only in Ethiopia but in Nigeria. Utilization of Machine Learning (ML) algorithm in the study is a novel idea and amplifies use of technology &#x2013; artificial intelligence in health disciplines&#x2019; investigations. The six ML algorithms: LR, RF, KNN, XGBoost, NB and SVMs are widely used as study models. Methods of model training and selection were accurate, establishing the XGBoost as the best model for predictors identification, but poor in specificity ability. The rich source of data &#x2013; Performance Monitoring and Accountability (PMA) Ethiopia 2019 survey dataset provided a large sample for generalization of findings. &#x00a0;Overall, the study adds to the body of knowledge on MCs use, thus preventing abortions from unwanted and unplanned pregnancies. Findings will significantly contribute to the reduction in maternal morbidity and mortality deaths resulting from abortions and related complications.</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Yes</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Yes</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Yes</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>Yes</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>Yes</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Yes</p>
            <p>Reviewer Expertise:</p>
            <p>Maternal and Child Health</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.</p>
        </body>
    </sub-article>
</article>
