<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN" "http://jats.nlm.nih.gov/publishing/1.2/JATS-journalpublishing1.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="research-article" dtd-version="1.2" xml:lang="en">
    <front>
        <journal-meta>
            <journal-id journal-id-type="pmc">F1000Research</journal-id>
            <journal-title-group>
                <journal-title>F1000Research</journal-title>
            </journal-title-group>
            <issn pub-type="epub">2046-1402</issn>
            <publisher>
                <publisher-name>F1000 Research Limited</publisher-name>
                <publisher-loc>London, UK</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="doi">10.12688/f1000research.176533.1</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Research Article</subject>
                </subj-group>
                <subj-group>
                    <subject>Articles</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Compact Adaptive Feature Extraction (CAFE): A Bandwidth-Aware Multi-Domain Monitoring Framework for Elderly Care - Novel Approach</article-title>
                <fn-group content-type="pub-status">
                    <fn>
                        <p>[version 1; peer review: awaiting peer review]</p>
                    </fn>
                </fn-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author" corresp="yes">
                    <name>
                        <surname>Abdulhameed</surname>
                        <given-names>Zainab</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Software</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <xref ref-type="corresp" rid="c1">a</xref>
                    <xref ref-type="aff" rid="a1">1</xref>
                    <xref ref-type="aff" rid="a2">2</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Al Mashhadany</surname>
                        <given-names>Yousif</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0003-3943-8395</uri>
                    <xref ref-type="aff" rid="a3">3</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>M. Salman</surname>
                        <given-names>Tariq</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <aff id="a1">
                    <label>1</label>Electrical Engineering, Mustansiriyah University Faculty of Engineering, Baghdad, Baghdad Governorate, 10001, Iraq</aff>
                <aff id="a2">
                    <label>2</label>Electrical engineering, University of Anbar College of Engineering, Baghdad, Baghdad Governorate, 31001, Iraq</aff>
                <aff id="a3">
                    <label>3</label>Biomedical Engineering Research Center, University of Anbar, Ramadi, Al Anbar Governorate, 31001, Iraq</aff>
            </contrib-group>
            <author-notes>
                <corresp id="c1">
                    <label>a</label>
                    <email xlink:href="mailto:zainab.abdulhameed@uomustansiriyah.edu.iq">zainab.abdulhameed@uomustansiriyah.edu.iq</email>
                </corresp>
                <fn fn-type="conflict">
                    <p>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>31</day>
                <month>3</month>
                <year>2026</year>
            </pub-date>
            <pub-date pub-type="collection">
                <year>2026</year>
            </pub-date>
            <volume>15</volume>
            <elocation-id>457</elocation-id>
            <history>
                <date date-type="accepted">
                    <day>30</day>
                    <month>1</month>
                    <year>2026</year>
                </date>
            </history>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2026 Abdulhameed Z et al.</copyright-statement>
                <copyright-year>2026</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <self-uri content-type="pdf" xlink:href="https://f1000research.com/articles/15-457/pdf"/>
            <abstract>
                <sec>
                    <title>Background</title>
                    <p>Remote monitoring for older adults is often limited by very low network bandwidth in rural and resource-constrained regions. Sending full biosignals is impractical, and many alternatives either reduce clinical coverage or need infrastructure that isn&#x2019;t available.</p>
                </sec>
                <sec>
                    <title>Methods</title>
                    <p>We built the Compact Adaptive Feature Extraction (CAFE) framework to monitor multiple domains using electroencephalography (EEG), electromyography (EMG), electrocardiography (ECG), and electrooculography (EOG). CAFE selects stable, clinically interpretable features and adjusts how many are sent based on available bandwidth. Validation used public data; the primary labeled test used the UCI EMG Physical Action Data Set (10 activities, 4 subjects; 187 four-second windows).</p>
                </sec>
                <sec>
                    <title>Results</title>
                    <p>In the bandwidth-oriented comparison, CAFE reached 70.8% F1 using five features at 0.040 kbps, versus 69.8% F1 for a statistical baseline using eight features at 0.064 kbps (&#x0394;F1 = 0.93 percentage points; 95% CI [&#x2212;4.51, 6.43]; p = 0.393), showing no statistically significant difference despite a 37.5% reduction in features/bandwidth. Independent binary fall-risk validation on the EMG windows yielded 57.8% F1, 64.9% sensitivity, 73.8% specificity, and AUC = 0.70.</p>
                </sec>
                <sec>
                    <title>Conclusions</title>
                    <p>CAFE provides practical elderly monitoring under tight bandwidth limits by preserving detection performance while sending much less data. Its adaptive, feature-based transmission makes it suitable for deployment in clinics and remote care settings with limited connectivity.</p>
                </sec>
            </abstract>
            <kwd-group kwd-group-type="author">
                <kwd>CAFE ; Elderly monitoring; Multi-modal biosignals; Bandwidth optimization; Feature selection; IoT; Resource-constrained systems</kwd>
            </kwd-group>
            <funding-group>
                <funding-statement>The author(s) declared that no grants were involved in supporting this work.</funding-statement>
            </funding-group>
        </article-meta>
    </front>
    <body>
        <sec id="sec5" sec-type="intro">
            <title>I. Introduction</title>
            <p>Remote health monitoring systems have become a vital component of elderly health care, especially since it is estimated that by 2050, the number of those aged 65+ and above will rise to 1.5 billion. The geographical and economic barriers that characterize traditional healthcare delivery appear to be insurmountable in resource-limited settings.
                <sup>
                    <xref ref-type="bibr" rid="ref1">1</xref>&#x2013;
                    <xref ref-type="bibr" rid="ref4">4</xref>
                </sup> The combination of Internet of Things (IoT) and multimodal biosignal analysis offers complete patient monitoring by obtaining constant and continuous electroencephalography (EEG), electromyography (EMG), electrocardiography (ECG), and electrooculography (EOG) signals.
                <sup>
                    <xref ref-type="bibr" rid="ref5">5</xref>,
                    <xref ref-type="bibr" rid="ref6">6</xref>
                </sup> However, its actual implementation is limited by bandwidth constraints, namely the bandwidth of the wireless networks in rural and developing areas; in many cases, the uplink bandwidth is less than 2 kilobits per second (kbps) - not to support traditional multimodal monitoring methods.</p>
            <p>The existing feature extraction methods of these modalities are spectral band power analysis of EEG,
                <sup>
                    <xref ref-type="bibr" rid="ref7">7</xref>,
                    <xref ref-type="bibr" rid="ref8">8</xref>
                </sup> EMG-based gait, muscle coordination measures
                <sup>
                    <xref ref-type="bibr" rid="ref9">9</xref>,
                    <xref ref-type="bibr" rid="ref10">10</xref>
                </sup> heart rate variability (HRV) as a predictor of falls,
                <sup>
                    <xref ref-type="bibr" rid="ref11">11</xref>&#x2013;
                    <xref ref-type="bibr" rid="ref13">13</xref>
                </sup> and EOG-derived blink patterns to detect alertness loss.
                <sup>
                    <xref ref-type="bibr" rid="ref14">14</xref>
                </sup> Multimodal biosignal monitoring (EEG, EMG, ECG, and EOG) generates high-dimensional feature sets with a high redundancy rate; however, practical implementations are limited by the uplink bandwidth. Individual processing pipelines for each modality may fail to capture intersystem interactions at the clinical level of interest, including cardio-neuromuscular coupling and posture-neural interactions, which are of clinical significance in blocking fall risk. Recent developments in coupling analysis show that cortical muscular coherence
                <sup>
                    <xref ref-type="bibr" rid="ref15">15</xref>,
                    <xref ref-type="bibr" rid="ref16">16</xref>
                </sup> and multichannel EMG coordination
                <sup>
                    <xref ref-type="bibr" rid="ref17">17</xref>
                </sup> are both clinically relevant and diagnostically salient features and can be employed in feature classification, although computational costs tend to restrict real-time
 use.</p>
            <p>The approach used in this study is a compact, cross-modal feature, where patterns of interest and redundant patterns are removed, allowing useful decision-making using compact bandwidth resources. Existing multimodal systems of elderly monitoring utilize 8-14 features per 4-second window (0.064-0.112 kbps transmission).
                <sup>
                    <xref ref-type="bibr" rid="ref2">2</xref>,
                    <xref ref-type="bibr" rid="ref18">18</xref>
                </sup> Although these appear modest, they outperform bandwidth availability in most deployment scenarios (rural 2G networks and satellite links), burn battery life on wearables,
                <sup>
                    <xref ref-type="bibr" rid="ref19">19</xref>
                </sup> and full-time multi-domain health measurement is not possible. The difficulty increases in older age groups who need long-term multi-domain surveillance (cardiac, cognitive, and mobility) in non-homogenous subjects, and they are not individualized.
                <sup>
                    <xref ref-type="bibr" rid="ref3">3</xref>,
                    <xref ref-type="bibr" rid="ref20">20</xref>,
                    <xref ref-type="bibr" rid="ref21">21</xref>
                </sup> Existing studies take divergent directions: maximizing detection accuracy (large sets of features), minimizing transmission (vicious compression), and seldom cooperating.
                <sup>
                    <xref ref-type="bibr" rid="ref5">5</xref>,
                    <xref ref-type="bibr" rid="ref18">18</xref>,
                    <xref ref-type="bibr" rid="ref19">19</xref>
                </sup>
            </p>
            <p>This work presents the CAFE framework for multi-domain elderly monitoring, which adopts this dual challenge through intelligent feature selection that maintains clinical efficacy while significantly reducing bandwidth requirements, the general flow of the work is shown in 
                <xref ref-type="fig" rid="f1">Figure 1</xref>. Unlike previous studies that were optimized for single subjects or synchronized recordings,
                <sup>
                    <xref ref-type="bibr" rid="ref5">5</xref>,
                    <xref ref-type="bibr" rid="ref18">18</xref>
                </sup> CAFE operates across heterogeneous populations without calibration, making it suitable for large-scale deployments. CAFE achieved 70.8% F1 score in multi-domain health event detection (cardiac, cognitive, mobility) using five features at 0.040 kbps, no statistically significant difference to traditional methods' 69.8% F1 with eight features at 0.064 kbps (p=0.393).</p>
            <fig fig-type="figure" id="f1" orientation="portrait" position="float">
                <label>
Figure 1. </label>
                <caption>
                    <title>General framework of adaptive bandwidth with feature extraction.</title>
                </caption>
                <graphic id="gr1" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/194597/abaf3938-91e4-4367-8f28-85fa4c95f545_figure1.gif"/>
            </fig>
            <p>Finally, this work makes four primary contributions: shows that comparable detection performance can be maintained with 37.5% fewer transmitted features; The work is demonstrated to be stable across a heterogeneous population of more than 100 subjects without any subject-specific training; it quantifies the practical benefits such as 62% bandwidth efficiency gain (F1/kbps measure) and 9.02 per year savings in data transfer costs; and it uses the identification of stable population characteristics that are present in different groups of older adults.</p>
        </sec>
        <sec id="sec6">
            <title>II. Related work</title>
            <p>Recent advances in IoT-enabled health monitoring have investigated edge-computing architectures, multimodal biosignal analysis, feature extraction approaches, and resource-efficient algorithms. Edge computing is a critical model that has evolved into a real-time health-monitoring model. Smart healthcare was based on dynamic resource allocation by Chen et al.
                <sup>
                    <xref ref-type="bibr" rid="ref2">2</xref>
                </sup> and 210 ms response time and 95.4% detection accuracy on cardiac and fall events with sensor fusion and lightweight AI were developed by Alshuhail et al.
                <sup>
                    <xref ref-type="bibr" rid="ref3">3</xref>
                </sup> Ianculescu et al.
                <sup>
                    <xref ref-type="bibr" rid="ref1">1</xref>
                </sup> demonstrated the practicality of IoT-based monitoring using the Monit4Healthy. However, none of these works deal with bandwidth optimization or include a report of the costs of transmission, which is a critical need in resource-constrained deployments.</p>
            <p>The effectiveness of multimodal approaches has been extensively studied. Rodrigues et al.
                <sup>
                    <xref ref-type="bibr" rid="ref18">18</xref>
                </sup> introduced feature-based retrieval using self-similarity matrices, whereas Sadras et al.
                <sup>
                    <xref ref-type="bibr" rid="ref20">20</xref>
                </sup> introduced event detection for multimodal time series. Most recently, Oladunni and Wong
                <sup>
                    <xref ref-type="bibr" rid="ref21">21</xref>
                </sup> determined that complementary domains of features (time + time-frequency) perform better (96% accuracy) than multi-domain fusion (redundant), a concept behind feature selection used by CAF&#x00c9;. Choudhary et al.
                <sup>
                    <xref ref-type="bibr" rid="ref22">22</xref>
                </sup> investigated multi-domain EEG fusion using reduced electrode setup. However, these studies put more emphasis on the maximization of accuracy, disregarding bandwidth limitations and nonstop transmission expenses.</p>
            <p>Lim and Lee conducted a comprehensive review of elderly monitoring feature extraction methods,
                <sup>
                    <xref ref-type="bibr" rid="ref23">23</xref>
                </sup> while other researchers presented another direction to use feature extraction such as gait-based fall detection,
                <sup>
                    <xref ref-type="bibr" rid="ref4">4</xref>,
                    <xref ref-type="bibr" rid="ref9">9</xref>,
                    <xref ref-type="bibr" rid="ref10">10</xref>,
                    <xref ref-type="bibr" rid="ref39">39</xref>
                </sup> EEG cognitive markers,
                <sup>
                    <xref ref-type="bibr" rid="ref7">7</xref>,
                    <xref ref-type="bibr" rid="ref8">8</xref>
                </sup> cardiac HRV,
                <sup>
                    <xref ref-type="bibr" rid="ref11">11</xref>&#x2013;
                    <xref ref-type="bibr" rid="ref13">13</xref>
                </sup> and EOG vigilance
                <sup>
                    <xref ref-type="bibr" rid="ref14">14</xref>
                </sup> have specialized methods. Advanced metrics of coupling
                <sup>
                    <xref ref-type="bibr" rid="ref15">15</xref>&#x2013;
                    <xref ref-type="bibr" rid="ref17">17</xref>
                </sup> necessitate synchronized records that cannot be found in multisubject datasets. These studies focused on feature engineering, but not on bandwidth-performance trade-offs. whereas Bagal&#x00e0; et al.
                <sup>
                    <xref ref-type="bibr" rid="ref19">19</xref>
                </sup> established fall detection benchmarks (60-75% sensitivity) on real-world data. In an attempt to optimize the feature selection of an IoT intrusion, Mehssen and Al_Hamdawaee
                <sup>
                    <xref ref-type="bibr" rid="ref24">24</xref>
                </sup> adopted RFE and PSO. Such studies go a step further in promoting feature engineering, but not the trade-off between feature richness and bandwidth efficiency.</p>
            <p>Wearable systems have become resource-efficient. Stuart et al.
                <sup>
                    <xref ref-type="bibr" rid="ref25">25</xref>
                </sup> named power consumption a critical bottleneck, as they reported that wireless transmission occupies a major part of energy consumption. Mostafa et al.
                <sup>
                    <xref ref-type="bibr" rid="ref26">26</xref>
                </sup> and Kumar et al.
                <sup>
                    <xref ref-type="bibr" rid="ref27">27</xref>
                </sup> proposedenergy-efficient AI algorithms, but emphasized the use of computational, not communication, efficiency.</p>
            <p>Special-purpose systems have been developed for vital sign monitoring,
                <sup>
                    <xref ref-type="bibr" rid="ref5">5</xref>,
                    <xref ref-type="bibr" rid="ref28">28</xref>
                </sup> assistive technologies,
                <sup>
                    <xref ref-type="bibr" rid="ref6">6</xref>
                </sup> and Alzheimer's classification,
                <sup>
                    <xref ref-type="bibr" rid="ref29">29</xref>
                </sup> but they typically focus on single conditions without bandwidth optimization. Graph-theoretical approaches
                <sup>
                    <xref ref-type="bibr" rid="ref30">30</xref>&#x2013;
                    <xref ref-type="bibr" rid="ref33">33</xref>
                </sup> offer principled frameworks for capturing inter channel relationships but require precise synchronization and are sensitive to noise. The graph features were very unstable, with a coefficient of variation (CV) &gt; 0.4. Therefore, in the CAFE multi-subject dataset, and could not be used. Nevertheless, such coupling measures can be useful in patient-specific monitoring when calculated using synchronized same-subject measurements, allowing individual risk profiles once the baseline connectivity patterns of an individual are known.
                <sup>
                    <xref ref-type="bibr" rid="ref30">30</xref>,
                    <xref ref-type="bibr" rid="ref31">31</xref>
                </sup>
            </p>
            <p>In spite of tremendous advancement, three gaps need addressing: there is little to no bandwidth optimization practices reported although resource-constrained deployments require this technique, multi-domain monitoring in practice targets individual conditions instead of simultaneous cardiac, cognitive, and mobility measurements, and cross-subject generalization without calibration is still a challenge. The first framework to clearly optimize bandwidth (0.040 kbps, 37.5% reduction) and at the same time measures three domains of health in 163 heterogeneous subjects without any calibration; no statistically significant difference (p=0.393) was achieved by CAFE. 
                <xref ref-type="table" rid="T1">
Table 1</xref> summarizes the research landscape and the unique contributions of CAFEs.</p>
            <table-wrap id="T1" orientation="portrait" position="float">
                <label>
Table 1. </label>
                <caption>
                    <title>Related work summary and CAFE positioning.</title>
                </caption>
                <table content-type="article-table" frame="hsides">
                    <thead>
                        <tr>
                            <th align="left" colspan="1" rowspan="1" valign="top">
Research Focus</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">
Key Works</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">
Main Contribution</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">
Bandwidth Optimization</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">
Multi-Domain
</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">
Cross-Subject
</th>
                            <th align="left" colspan="1" rowspan="1" valign="top">
Gap for CAFE</th>
                        </tr>
                    </thead>
                    <tbody>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Edge Computing</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Chen,
                                <sup>
                                    <xref ref-type="bibr" rid="ref2">2</xref>
                                </sup> Alshuhail,
                                <sup>
                                    <xref ref-type="bibr" rid="ref3">3</xref>
                                </sup> Ianculescu
                                <sup>
                                    <xref ref-type="bibr" rid="ref1">1</xref>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Real-time processing; 95.4% accuracy; 210 ms latency</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Not reported</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">1-2 domains</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Limited</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">No bandwidth metrics</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Multimodal Analysis</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Rodrigues,
                                <sup>
                                    <xref ref-type="bibr" rid="ref18">18</xref>
                                </sup> Oladunni &amp; Wong,
                                <sup>
                                    <xref ref-type="bibr" rid="ref21">21</xref>
                                </sup> Sadras
                                <sup>
                                    <xref ref-type="bibr" rid="ref20">20</xref>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Feature complementarity; 96% accuracy</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Accuracy focus</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Yes</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">N/A</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Not continuous monitoring</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Feature Selection</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Lim &amp; Lee,
                                <sup>
                                    <xref ref-type="bibr" rid="ref23">23</xref>
                                </sup> Choudhary,
                                <sup>
                                    <xref ref-type="bibr" rid="ref22">22</xref>
                                </sup> Mehssen
                                <sup>
                                    <xref ref-type="bibr" rid="ref24">24</xref>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Scoping reviews; reduced electrodes; RFE+PSO</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Assumes unlimited</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Single modality</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Small cohorts</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">No bandwidth-performance trade-off
</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Energy Efficiency</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Stuart,
                                <sup>
                                    <xref ref-type="bibr" rid="ref25">25</xref>
                                </sup> Mostafa,
                                <sup>
                                    <xref ref-type="bibr" rid="ref26">26</xref>
                                </sup> Kumar
                                <sup>
                                    <xref ref-type="bibr" rid="ref27">27</xref>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Wearable constraints; energy-efficient DNNs</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Partial (energy)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Single domain</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Not primary</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Computational not communication</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">Application Systems</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Chen &amp; Sheng,
                                <sup>
                                    <xref ref-type="bibr" rid="ref5">5</xref>
                                </sup> Almujally,
                                <sup>
                                    <xref ref-type="bibr" rid="ref6">6</xref>
                                </sup> Bagal&#x00e0;,
                                <sup>
                                    <xref ref-type="bibr" rid="ref19">19</xref>
                                </sup> Yahia
                                <sup>
                                    <xref ref-type="bibr" rid="ref38">38</xref>
                                </sup>
                            </td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Fall detection; vital signs; Alzheimer's</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Not addressed</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Single condition</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Varied</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">No bandwidth optimization</td>
                        </tr>
                        <tr>
                            <td align="left" colspan="1" rowspan="1" valign="top">CAFE (This Work)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">2025</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Bandwidth-optimized multi-domain monitoring</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">0.040 kbps (37.5% reduction)</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">3 domains</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">163 subjects</td>
                            <td align="left" colspan="1" rowspan="1" valign="top">Addresses all gaps</td>
                        </tr>
                    </tbody>
                </table>
            </table-wrap>
            <p>

                <bold>Note:</bold> CAFE uniquely combines explicit bandwidth optimization (0.040 kbps), multi-domain coverage (cardiac + cognitive + mobility), and cross-subject validation (163 subjects, no calibration) with no statistically significant difference (p=0.393).</p>
        </sec>
        <sec id="sec7">
            <title>III. Methodology</title>
            <p>The CAF&#x00c9; (Novel Approach) framework minimizes data transmission requirements while maintaining clinical efficacy for multi-domain elderly health monitoring (cardiac, cognitive, mobility), as shown in the flow chart in 
                <xref ref-type="fig" rid="f2">Figure 2</xref>.</p>
            <fig fig-type="figure" id="f2" orientation="portrait" position="float">
                <label>
Figure 2. </label>
                <caption>
                    <title>Flow chart of the proposed work (Novel approach).</title>
                </caption>
                <graphic id="gr2" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/194597/abaf3938-91e4-4367-8f28-85fa4c95f545_figure2.gif"/>
            </fig>
            <sec id="sec8">
                <title>3.1 Dataset and acquisition</title>
                <p>128 EEG files, 25 EOG records, and approximately10 EMG subjects during several activity sessions. These were non-overlapping cohorts (no synchronized recordings of the same subject). To discover initial features, signals were synchronized to a shared length (40245) of 2.6 min (256 Hz sampling rate) resulting in 77 multimodal windows 4-s long with 50% overlap. To validate this, 187 labeled EMG windows were used for 10 activity classes (bowing, clapping, handshaking, hugging, jumping, running, sitting, standing, walking, and waving) of 97,143 samples. The activities were categorized into fall risk (bowing, jumping, running; n=57 windows) and normal (sitting, standing, walking; n=130 windows) to perform a binary classification evaluation.</p>
                <p>The datasets utilized in this study were all publicly available and had been collected and anonymized by their source authors. No new human subjects were identified and no identifiable human data obtained. The datasets in use are the Physical Action Data Set (EMG): UCI machine learning repository and the EEG data: Kaggle and EOG data: Zenodo, which are freely available and can be used in research. Thus, this secondary analysis of the existing anonymized data did not need ethical approval and informed consent.</p>
            </sec>
            <sec id="sec9">
                <title>3.2 Signal preprocessing</title>
                <p>All the signals were obtained at a sampling frequency of 256 Hz using anti-aliasing filters. Continuous signals were segmented into 4-s segments. windows with overlap of 50%, providing the processing and transmission harmony throughout the framework. Each channel underwent z-score normalization with variance checking (std &gt; 10
                    <sup>&#x2212;10</sup>) to avoid numerical instability; the remaining nonfinite values were set to zero.
                    <sup>
                        <xref ref-type="bibr" rid="ref40">40</xref>
                    </sup> To remove baseline drift and out-of-band noise while preserving spectral content, third-order zero-phase Butterworth bandpass filters were applied with modality-specific cutoffs, as follows:
                    <list list-type="bullet">
                        <list-item>
                            <label>-</label>
                            <p>EEG: 0.5&#x2013;45 Hz (preserving delta through low gamma bands)</p>
                        </list-item>
                        <list-item>
                            <label>-</label>
                            <p>EMG: 10&#x2013;100 Hz (which captures muscle activation while rejecting motion artifacts)</p>
                        </list-item>
                        <list-item>
                            <label>-</label>
                            <p>ECG: 0.5&#x2013;40 Hz (which retains QRS; heart wave; complex morphology)</p>
                        </list-item>
                        <list-item>
                            <label>-</label>
                            <p>EOG: 0.1&#x2013;20 Hz (which isolates ocular movements and blink artifacts)</p>
                        </list-item>
                    </list>
                </p>
            </sec>
            <sec id="sec10">
                <title>3.3 Feature extraction</title>
                <p>From each 4-s window, a compact set of interpretable features spanning clinical domains was computed
                    <sup>
                        <xref ref-type="bibr" rid="ref37">37</xref>
                    </sup>:
                    <list list-type="bullet">
                        <list-item>
                            <label>-</label>
                            <p>Cognitive Domain (EEG): Relative band powers (&#x03b4;: 0.5&#x2013;4 Hz, &#x03b8;: 4&#x2013;8 Hz, &#x03b1;: 8&#x2013;13 Hz, &#x03b2;: 13&#x2013;30 Hz) were computed via 512-point FFT using a single power spectral density (PSD) estimation, normalized to unit sum.
                                <sup>
                                    <xref ref-type="bibr" rid="ref34">34</xref>
                                </sup>
                            </p>
                        </list-item>
                    </list>
                </p>
                <p>The slowing ratio calculated using 
                    <xref ref-type="disp-formula" rid="e1">Equation (1)</xref>, which quantifies the pathological frequency shifts characteristic of cognitive decline.
                    <sup>
                        <xref ref-type="bibr" rid="ref8">8</xref>
                    </sup>
                    <disp-formula id="e1">

                        <mml:math display="block">
                            <mml:mi mathvariant="italic">SR</mml:mi>
                            <mml:mo>=</mml:mo>
                            <mml:mfrac>
                                <mml:mrow>
                                    <mml:mo stretchy="true">(</mml:mo>
                                    <mml:msub>
                                        <mml:mi>P</mml:mi>
                                        <mml:mi>&#x03b4;</mml:mi>
                                    </mml:msub>
                                    <mml:mo>+</mml:mo>
                                    <mml:msub>
                                        <mml:mi>P</mml:mi>
                                        <mml:mi>&#x03b8;</mml:mi>
                                    </mml:msub>
                                    <mml:mo stretchy="true">)</mml:mo>
                                </mml:mrow>
                                <mml:mrow>
                                    <mml:mo stretchy="true">(</mml:mo>
                                    <mml:msub>
                                        <mml:mi>P</mml:mi>
                                        <mml:mi>&#x03b1;</mml:mi>
                                    </mml:msub>
                                    <mml:mo>+</mml:mo>
                                    <mml:msub>
                                        <mml:mi>P</mml:mi>
                                        <mml:mi>&#x03b2;</mml:mi>
                                    </mml:msub>
                                    <mml:mo>+</mml:mo>
                                    <mml:mi>&#x03b5;</mml:mi>
                                    <mml:mo stretchy="true">)</mml:mo>
                                </mml:mrow>
                            </mml:mfrac>
                        </mml:math>

                        <label>(1)</label>
</disp-formula>

                    <list list-type="bullet">
                        <list-item>
                            <label>-</label>
                            <p>Mobility Domain (EMG): Average power (window RMS) and mobility characterizing muscle activity patterns are calculated as in 
                                <xref ref-type="disp-formula" rid="e2">Equations (2</xref> and 
                                <xref ref-type="disp-formula" rid="e3">3</xref>)
                                <sup>
                                    <xref ref-type="bibr" rid="ref35">35</xref>,
                                    <xref ref-type="bibr" rid="ref36">36</xref>
                                </sup>:</p>
                        </list-item>
                    </list>

                    <disp-formula id="e2">

                        <mml:math display="block">
                            <mml:msub>
                                <mml:mi>P</mml:mi>
                                <mml:mi mathvariant="italic">EMG</mml:mi>
                            </mml:msub>
                            <mml:mo>=</mml:mo>
                            <mml:mrow>
                                <mml:mo stretchy="true">(</mml:mo>
                                <mml:mfrac>
                                    <mml:mn>1</mml:mn>
                                    <mml:mi>N</mml:mi>
                                </mml:mfrac>
                                <mml:mo stretchy="true">)</mml:mo>
                            </mml:mrow>
                            <mml:msubsup>
                                <mml:mi>&#x03a3;</mml:mi>
                                <mml:mrow>
                                    <mml:mi>t</mml:mi>
                                    <mml:mo>=</mml:mo>
                                    <mml:mn>1</mml:mn>
                                </mml:mrow>
                                <mml:mi>N</mml:mi>
                            </mml:msubsup>
                            <mml:msqrt>
                                <mml:mrow>
                                    <mml:mrow>
                                        <mml:mo stretchy="true">(</mml:mo>
                                        <mml:mfrac>
                                            <mml:mn>1</mml:mn>
                                            <mml:mi>C</mml:mi>
                                        </mml:mfrac>
                                        <mml:mo stretchy="true">)</mml:mo>
                                    </mml:mrow>
                                    <mml:msubsup>
                                        <mml:mi>&#x03a3;</mml:mi>
                                        <mml:mrow>
                                            <mml:mi>c</mml:mi>
                                            <mml:mo>=</mml:mo>
                                            <mml:mn>1</mml:mn>
                                        </mml:mrow>
                                        <mml:mi>C</mml:mi>
                                    </mml:msubsup>
                                    <mml:msubsup>
                                        <mml:mi>x</mml:mi>
                                        <mml:mi>c</mml:mi>
                                        <mml:mn>2</mml:mn>
                                    </mml:msubsup>
                                    <mml:mrow>
                                        <mml:mo stretchy="true">(</mml:mo>
                                        <mml:mi>t</mml:mi>
                                        <mml:mo stretchy="true">)</mml:mo>
                                    </mml:mrow>
                                </mml:mrow>
                            </mml:msqrt>
                        </mml:math>

                        <label>(2)</label>
</disp-formula>

                    <disp-formula id="e3">

                        <mml:math display="block">
                            <mml:msub>
                                <mml:mi>M</mml:mi>
                                <mml:mi mathvariant="italic">EMG</mml:mi>
                            </mml:msub>
                            <mml:mo>=</mml:mo>
                            <mml:mrow>
                                <mml:mo stretchy="true">(</mml:mo>
                                <mml:mfrac>
                                    <mml:mn>1</mml:mn>
                                    <mml:mi>C</mml:mi>
                                </mml:mfrac>
                                <mml:mo stretchy="true">)</mml:mo>
                            </mml:mrow>
                            <mml:msubsup>
                                <mml:mi>&#x03a3;</mml:mi>
                                <mml:mrow>
                                    <mml:mi>c</mml:mi>
                                    <mml:mo>=</mml:mo>
                                    <mml:mn>1</mml:mn>
                                </mml:mrow>
                                <mml:mi>C</mml:mi>
                            </mml:msubsup>
                            <mml:mrow>
                                <mml:mo stretchy="true">[</mml:mo>
                                <mml:mfrac>
                                    <mml:mrow>
                                        <mml:mi mathvariant="italic">std</mml:mi>
                                        <mml:mrow>
                                            <mml:mo stretchy="true">(</mml:mo>
                                            <mml:mi>&#x0394;</mml:mi>
                                            <mml:msub>
                                                <mml:mi>x</mml:mi>
                                                <mml:mi>c</mml:mi>
                                            </mml:msub>
                                            <mml:mo stretchy="true">)</mml:mo>
                                        </mml:mrow>
                                    </mml:mrow>
                                    <mml:mrow>
                                        <mml:mo stretchy="true">(</mml:mo>
                                        <mml:mi mathvariant="italic">std</mml:mi>
                                        <mml:mrow>
                                            <mml:mo stretchy="true">(</mml:mo>
                                            <mml:msub>
                                                <mml:mi>x</mml:mi>
                                                <mml:mi>c</mml:mi>
                                            </mml:msub>
                                            <mml:mo stretchy="true">)</mml:mo>
                                        </mml:mrow>
                                        <mml:mo>+</mml:mo>
                                        <mml:mi>&#x03b5;</mml:mi>
                                        <mml:mo stretchy="true">)</mml:mo>
                                    </mml:mrow>
                                </mml:mfrac>
                                <mml:mo stretchy="true">]</mml:mo>
                            </mml:mrow>
                        </mml:math>

                        <label>(3)</label>
</disp-formula>where N is the window length, C is the channel count, and &#x03b5;=10
                    <sup>&#x2212;6</sup> prevents division by zero. Additional motion descriptors (jerkiness from second temporal differences, bilateral asymmetry, and inter-channel coupling via correlation) were computed for fall risk validation but excluded from the final CAFE transmission set owing to redundancy with power and mobility features.</p>
                <p>

                    <italic toggle="yes">Cardiac Domain (ECG)</italic>
</p>
                <p>Heart rate and variability were extracted from R-peak intervals detected with amplitude (0.5&#x03c3;
                    <sub>ECG</sub>) and refractory (0.5s minimum interval) constraints, which were analyzed as in 
                    <xref ref-type="disp-formula" rid="e4 e5">Eqs.(4)-(5)</xref>
                    <sup>
                        <xref ref-type="bibr" rid="ref11">11</xref>,
                        <xref ref-type="bibr" rid="ref13">13</xref>
                    </sup>:
                    <disp-formula id="e4">

                        <mml:math display="block">
                            <mml:mi mathvariant="italic">HR</mml:mi>
                            <mml:mo>=</mml:mo>
                            <mml:mfrac>
                                <mml:mn>60</mml:mn>
                                <mml:mrow>
                                    <mml:mtext mathvariant="italic">mean</mml:mtext>
                                    <mml:mrow>
                                        <mml:mo stretchy="true">(</mml:mo>
                                        <mml:mi>R</mml:mi>
                                        <mml:msub>
                                            <mml:mi>R</mml:mi>
                                            <mml:mtext mathvariant="italic">intervals</mml:mtext>
                                        </mml:msub>
                                        <mml:mo stretchy="true">)</mml:mo>
                                    </mml:mrow>
                                </mml:mrow>
                            </mml:mfrac>
                            <mml:mspace width="0.25em"/>
                            <mml:mrow>
                                <mml:mo stretchy="true">[</mml:mo>
                                <mml:mtext>beats</mml:mtext>
                                <mml:mspace width="0.25em"/>
                                <mml:mi>per</mml:mi>
                                <mml:mspace width="0.25em"/>
                                <mml:mtext>minute</mml:mtext>
                                <mml:mspace width="0.25em"/>
                                <mml:mrow>
                                    <mml:mo stretchy="true">(</mml:mo>
                                    <mml:mi>bpm</mml:mi>
                                    <mml:mo stretchy="true">)</mml:mo>
                                </mml:mrow>
                                <mml:mo stretchy="true">]</mml:mo>
                            </mml:mrow>
                        </mml:math>

                        <label>(4)</label>
</disp-formula>

                    <disp-formula id="e5">

                        <mml:math display="block">
                            <mml:mi>HRV</mml:mi>
                            <mml:mo>=</mml:mo>
                            <mml:mi>std</mml:mi>
                            <mml:mrow>
                                <mml:mo stretchy="true">(</mml:mo>
                                <mml:mi>R</mml:mi>
                                <mml:msub>
                                    <mml:mi>R</mml:mi>
                                    <mml:mtext mathvariant="italic">intervals</mml:mtext>
                                </mml:msub>
                                <mml:mo stretchy="true">)</mml:mo>
                            </mml:mrow>
                            <mml:mo>&#x00d7;</mml:mo>
                            <mml:mn>1000</mml:mn>
                            <mml:mspace width="0.25em"/>
                            <mml:mrow>
                                <mml:mo stretchy="true">[</mml:mo>
                                <mml:mi>ms</mml:mi>
                                <mml:mo stretchy="true">]</mml:mo>
                            </mml:mrow>
                        </mml:math>

                        <label>(5)</label>
</disp-formula>

                    <list list-type="bullet">
                        <list-item>
                            <label>-</label>
                            <p>Ocular Domain (EOG): As a measure of cognitive alertness, blink rate was calculated using threshold crossings at 1.5&#x03c3;EOG, normalized to events per minute.</p>
                        </list-item>
                    </list>
                </p>
                <p>Intersignal correlation matrices and derived graph metrics (network density and clustering coefficient) are additional exploratory features. However, they were not included in the final transmission set, because they showed high population variability (CV&gt;0.4) in the asynchronous dataset.</p>
            </sec>
            <sec id="sec11">
                <title>3.4 Feature selection strategy</title>
                <p>To ensure cross-subject robustness without individual calibration, the CAFE uses a two-stage selection process.</p>
                <p>First, for stability filtering, for each candidate feature i across N windows, the Coefficient of Variation (CV) was computed as in 
                    <xref ref-type="disp-formula" rid="e6">Equation (6)</xref>:
                    <disp-formula id="e6">

                        <mml:math display="block">
                            <mml:mi>C</mml:mi>
                            <mml:msub>
                                <mml:mi>V</mml:mi>
                                <mml:mi>i</mml:mi>
                            </mml:msub>
                            <mml:mo>=</mml:mo>
                            <mml:mrow>
                                <mml:mo stretchy="true">(</mml:mo>
                                <mml:mfrac>
                                    <mml:msub>
                                        <mml:mi>&#x03c3;</mml:mi>
                                        <mml:mi>i</mml:mi>
                                    </mml:msub>
                                    <mml:msub>
                                        <mml:mi>&#x03bc;</mml:mi>
                                        <mml:mi>i</mml:mi>
                                    </mml:msub>
                                </mml:mfrac>
                                <mml:mo stretchy="true">)</mml:mo>
                            </mml:mrow>
                        </mml:math>

                        <label>(6)</label>
</disp-formula>where &#x03c3;
                    <sub>i</sub> and &#x03bc;
                    <sub>i</sub> are the standard deviation and mean, respectively, of feature i across the population.</p>
                <p>Features with CV &lt; 0.2 are retained as population-stable. This threshold through empirical observation identified features with steady behavior across heterogeneous subjects (e.g., EMG mobility CV=0.083, beta power CV=0.117, HR CV=0.165), while excluding highly variable metrics unsuitable for unsupervised deployment (e.g., HRV CV=0.392, graph-based coupling CV&gt;0.4).</p>
                <p>Second, The Discriminative Ratio (DR), which quantifies the separation between risk classes, was calculated using 
                    <xref ref-type="disp-formula" rid="e7">Equation (7)</xref>:
                    <disp-formula id="e7">

                        <mml:math display="block">
                            <mml:mi>D</mml:mi>
                            <mml:msub>
                                <mml:mi>R</mml:mi>
                                <mml:mi>i</mml:mi>
                            </mml:msub>
                            <mml:mo>=</mml:mo>
                            <mml:mfrac>
                                <mml:msubsup>
                                    <mml:mi>&#x03c3;</mml:mi>
                                    <mml:mrow>
                                        <mml:mtext mathvariant="italic">between</mml:mtext>
                                        <mml:mo>,</mml:mo>
                                        <mml:mi>i</mml:mi>
                                    </mml:mrow>
                                    <mml:mn>2</mml:mn>
                                </mml:msubsup>
                                <mml:msubsup>
                                    <mml:mi>&#x03c3;</mml:mi>
                                    <mml:mrow>
                                        <mml:mtext mathvariant="italic">within</mml:mtext>
                                        <mml:mo>,</mml:mo>
                                        <mml:mi>i</mml:mi>
                                    </mml:mrow>
                                    <mml:mn>2</mml:mn>
                                </mml:msubsup>
                            </mml:mfrac>
                        </mml:math>

                        <label>(7)</label>
</disp-formula>where &#x03c3;
                    <sup>2</sup>
                    <sub>between</sub> is the variance of the class means and &#x03c3;
                    <sup>2</sup>
                    <sub>within</sub> is the mean within-class variance, then a stability score was computed by combining both metrics, as in 
                    <xref ref-type="disp-formula" rid="e8">Equation (8)</xref>:
                    <disp-formula id="e8">

                        <mml:math display="block">
                            <mml:msub>
                                <mml:mi>S</mml:mi>
                                <mml:mi>i</mml:mi>
                            </mml:msub>
                            <mml:mo>=</mml:mo>
                            <mml:mfrac>
                                <mml:mrow>
                                    <mml:mi>D</mml:mi>
                                    <mml:msub>
                                        <mml:mi>R</mml:mi>
                                        <mml:mi>i</mml:mi>
                                    </mml:msub>
                                </mml:mrow>
                                <mml:mrow>
                                    <mml:mn>1</mml:mn>
                                    <mml:mo>+</mml:mo>
                                    <mml:mi>C</mml:mi>
                                    <mml:msub>
                                        <mml:mi>V</mml:mi>
                                        <mml:mi>i</mml:mi>
                                    </mml:msub>
                                </mml:mrow>
                            </mml:mfrac>
                        </mml:math>

                        <label>(8)</label>
</disp-formula>
                </p>
                <p>The features are ranked by S
                    <sub>i</sub> in descending order. The top F features allowed by the current bandwidth budget were selected for transmission. This procedure identified a 5-feature CAFE set: EMG power, EMG mobility, EMG asymmetry, heart rate, and EEG slowing ratio.</p>
                <p>In addition, inter-modal coupling features were computed in this framework (EEG-EMG correlation, EEG-ECG coherence, and graph density/clustering), which exhibited high instability (CV &gt; 0.4) in the asynchronous multi-subject dataset and were excluded from validation on synchronized, same-subject recordings.</p>
            </sec>
            <sec id="sec12">
                <title>3.5 Multi-domain event detection</title>
                <p>In this study, unsupervised event detection was implemented using two types: established medical thresholds (e.g., normal HR range) or percentiles calculated from the study population, which means that the method works immediately for any new patients without requiring days to acquire individual baseline measurements. And the detection criteria used in this work are cardiac events. First, it applies standard clinical ranges: HR outside [50, 100] bpm or HRV &lt; 20 ms. If more than 50% of windows are flagged (indicating the population may not match standard ranges), then it reverts to data-driven thresholds: HR below the 10th percentile, above the 90th percentile, or HRV below the 20th percentile.</p>
                <p>Cognitive events: Windows where SR exceeds the 80th percentile of the observed population distribution are flagged.
                    <list list-type="bullet">
                        <list-item>
                            <label>-</label>
                            <p>Mobility events: Windows where P
                                <sub>EMG</sub> exceeds the 85th percentile indicate an elevated fall risk.</p>
                        </list-item>
                    </list>
                </p>
                <p>Priority scoring: Each window receives a composite risk score:
                    <disp-formula id="e9">

                        <mml:math display="block">
                            <mml:mi mathvariant="normal">R</mml:mi>
                            <mml:mrow>
                                <mml:mo stretchy="true">(</mml:mo>
                                <mml:mi mathvariant="normal">w</mml:mi>
                                <mml:mo stretchy="true">)</mml:mo>
                            </mml:mrow>
                            <mml:mo>=</mml:mo>
                            <mml:msub>
                                <mml:mi mathvariant="normal">w</mml:mi>
                                <mml:mtext>cardiac</mml:mtext>
                            </mml:msub>
                            <mml:mo>&#x00d7;</mml:mo>
                            <mml:msub>
                                <mml:mi mathvariant="normal">I</mml:mi>
                                <mml:mtext>cardiac</mml:mtext>
                            </mml:msub>
                            <mml:mo>+</mml:mo>
                            <mml:msub>
                                <mml:mi mathvariant="normal">w</mml:mi>
                                <mml:mtext>mobility</mml:mtext>
                            </mml:msub>
                            <mml:mo>&#x00d7;</mml:mo>
                            <mml:msub>
                                <mml:mi mathvariant="normal">I</mml:mi>
                                <mml:mtext>mobility</mml:mtext>
                            </mml:msub>
                            <mml:mo>+</mml:mo>
                            <mml:msub>
                                <mml:mi mathvariant="normal">w</mml:mi>
                                <mml:mtext>cognitive</mml:mtext>
                            </mml:msub>
                            <mml:mo>&#x00d7;</mml:mo>
                            <mml:msub>
                                <mml:mi mathvariant="normal">I</mml:mi>
                                <mml:mtext>cognitive</mml:mtext>
                            </mml:msub>
                        </mml:math>

                        <label>(9)</label>
</disp-formula>where I
                    <sub>domain</sub> &#x2208; {0,1} denotes the threshold exceedance. Weights reflect clinical urgency hierarchies: w
                    <sub>cardiac</sub> = 2.0 (immediate life-threatening risks), w
                    <sub>mobility</sub> = 1.5 (urgent fall prevention), w
                    <sub>cognitive</sub> = 1.0 (longer-term monitoring). A maximum score of R = 4.5 occurs when all events are detected simultaneously. Priority classification: HIGH: R &gt; 2.5 (multiple events or cardiac + any other) MEDIUM: 1.5 &lt; R &#x2264; 2.5 (single high-severity event) LOW: 0 &lt; R &#x2264; 1.5 (single low-severity event).</p>
            </sec>
            <sec id="sec13">
                <title>3.6 Bandwidth adaptation</title>
                <p>The CAFE adjusts the transmitted feature count based on the available network capacity. Using 32-bit encoding and 
                    <inline-formula>

                        <mml:math display="inline">
                            <mml:msub>
                                <mml:mi>T</mml:mi>
                                <mml:mi>w</mml:mi>
                            </mml:msub>
                        </mml:math>
</inline-formula>=4-second windows, the bitrate for F features is calculated as in 
                    <xref ref-type="disp-formula" rid="e10">Equation (10)</xref>: 
                    <disp-formula id="e10">

                        <mml:math display="block">
                            <mml:msub>
                                <mml:mi>R</mml:mi>
                                <mml:mtext mathvariant="italic">kbps</mml:mtext>
                            </mml:msub>
                            <mml:mrow>
                                <mml:mo stretchy="true">(</mml:mo>
                                <mml:mi>F</mml:mi>
                                <mml:mo stretchy="true">)</mml:mo>
                            </mml:mrow>
                            <mml:mo>=</mml:mo>
                            <mml:mfrac>
                                <mml:mrow>
                                    <mml:mo stretchy="true">(</mml:mo>
                                    <mml:mi>F</mml:mi>
                                    <mml:mo>&#x00d7;</mml:mo>
                                    <mml:mn>32</mml:mn>
                                    <mml:mo stretchy="true">)</mml:mo>
                                </mml:mrow>
                                <mml:mrow>
                                    <mml:mo stretchy="true">(</mml:mo>
                                    <mml:mn>1000</mml:mn>
                                    <mml:mo>&#x00d7;</mml:mo>
                                    <mml:msub>
                                        <mml:mi>T</mml:mi>
                                        <mml:mi>w</mml:mi>
                                    </mml:msub>
                                    <mml:mo stretchy="true">)</mml:mo>
                                </mml:mrow>
                            </mml:mfrac>
                            <mml:mo>=</mml:mo>
                            <mml:mn>0.00</mml:mn>
                            <mml:mtext>8F</mml:mtext>
                        </mml:math>

                        <label>(10)</label>
</disp-formula>
                </p>
                <p>A three-level adaptation policy was implemented as in 
                    <xref ref-type="disp-formula" rid="e11">Equation (11)</xref>:
                    <disp-formula id="e11">

                        <mml:math display="block">
                            <mml:msub>
                                <mml:mi mathvariant="normal">F</mml:mi>
                                <mml:mi>tx</mml:mi>
                            </mml:msub>
                            <mml:mo>=</mml:mo>
                            <mml:mrow>
                                <mml:mo stretchy="true">{</mml:mo>
                                <mml:mtable displaystyle="true">
                                    <mml:mtr>
                                        <mml:mtd columnalign="left">
                                            <mml:maligngroup/>
                                            <mml:mn>3</mml:mn>
                                            <mml:mo>,</mml:mo>
                                        </mml:mtd>
                                        <mml:mtd>
                                            <mml:mtext>if</mml:mtext>
                                            <mml:mspace width="0.25em"/>
                                            <mml:msub>
                                                <mml:mi mathvariant="normal">B</mml:mi>
                                                <mml:mtext>avail</mml:mtext>
                                            </mml:msub>
                                            <mml:mo>&lt;</mml:mo>
                                            <mml:mn>0.75</mml:mn>
                                            <mml:mspace width="0.25em"/>
                                            <mml:mtext>kbps</mml:mtext>
                                        </mml:mtd>
                                    </mml:mtr>
                                    <mml:mtr>
                                        <mml:mtd columnalign="left">
                                            <mml:maligngroup/>
                                            <mml:mn>4</mml:mn>
                                            <mml:mo>,</mml:mo>
                                        </mml:mtd>
                                        <mml:mtd>
                                            <mml:mtext>if</mml:mtext>
                                            <mml:mspace width="0.25em"/>
                                            <mml:mn>0.75</mml:mn>
                                            <mml:mo>&#x2264;</mml:mo>
                                            <mml:msub>
                                                <mml:mi mathvariant="normal">B</mml:mi>
                                                <mml:mtext>avail</mml:mtext>
                                            </mml:msub>
                                            <mml:mo>&lt;</mml:mo>
                                            <mml:mn>2.0</mml:mn>
                                            <mml:mspace width="0.25em"/>
                                            <mml:mtext>kbps</mml:mtext>
                                            <mml:mspace width="0.25em"/>
                                        </mml:mtd>
                                    </mml:mtr>
                                    <mml:mtr>
                                        <mml:mtd columnalign="left">
                                            <mml:maligngroup/>
                                            <mml:mn>5</mml:mn>
                                            <mml:mo>,</mml:mo>
                                        </mml:mtd>
                                        <mml:mtd>
                                            <mml:mtext>if</mml:mtext>
                                            <mml:mspace width="0.25em"/>
                                            <mml:msub>
                                                <mml:mi mathvariant="normal">B</mml:mi>
                                                <mml:mtext>avail</mml:mtext>
                                            </mml:msub>
                                            <mml:mo>&#x2265;</mml:mo>
                                            <mml:mn>2.0</mml:mn>
                                            <mml:mspace width="0.25em"/>
                                            <mml:mtext>kbps</mml:mtext>
                                        </mml:mtd>
                                    </mml:mtr>
                                </mml:mtable>
                            </mml:mrow>
                        </mml:math>

                        <label>(11)</label>
</disp-formula>
                </p>
                <p>The features are transmitted in descending order by the stability score S
                    <sub>i</sub> (
                    <xref ref-type="disp-formula" rid="e8">
Equation 8</xref>), prioritizing the most informative descriptors. This yields: 0.5 kbps for three features (HR, P_EMG, SR) at 0.024 kbps, 1.0 kbps for four features (+EMG mobility) at 0.032 kbps. If 
                    <inline-formula>

                        <mml:math display="inline">
                            <mml:msub>
                                <mml:mi mathvariant="normal">B</mml:mi>
                                <mml:mtext>avail</mml:mtext>
                            </mml:msub>
                        </mml:math>
</inline-formula> &#x2265;2.0 kbps then five features will be transmitted (+asymmetry) at 0.040 kbps.</p>
                <p>The 5-feature cap leaves &gt;99% of bandwidth available to concurrent patients at typical link capacities (5-10 kbps).</p>
                <p>
For the analysis of the economic impact, the daily data volume and yearly cost per patient were calculated using 
                    <xref ref-type="disp-formula" rid="e12 e13">Eqs.(12)-(13)</xref>:
                    <disp-formula id="e12">

                        <mml:math display="block">
                            <mml:msub>
                                <mml:mi>D</mml:mi>
                                <mml:mi mathvariant="italic">day</mml:mi>
                            </mml:msub>
                            <mml:mo>=</mml:mo>
                            <mml:mfrac>
                                <mml:mrow>
                                    <mml:mo stretchy="true">(</mml:mo>
                                    <mml:mi>F</mml:mi>
                                    <mml:mo>&#x00d7;</mml:mo>
                                    <mml:mn>32</mml:mn>
                                    <mml:mo stretchy="true">)</mml:mo>
                                </mml:mrow>
                                <mml:mrow>
                                    <mml:mo stretchy="true">(</mml:mo>
                                    <mml:mn>8</mml:mn>
                                    <mml:mo>&#x00d7;</mml:mo>
                                    <mml:msub>
                                        <mml:mi>T</mml:mi>
                                        <mml:mi>w</mml:mi>
                                    </mml:msub>
                                    <mml:mo stretchy="true">)</mml:mo>
                                </mml:mrow>
                            </mml:mfrac>
                            <mml:mo>&#x00b7;</mml:mo>
                            <mml:mfrac>
                                <mml:mn>86400</mml:mn>
                                <mml:msup>
                                    <mml:mn>1024</mml:mn>
                                    <mml:mn>2</mml:mn>
                                </mml:msup>
                            </mml:mfrac>
                            <mml:mspace width="0.25em"/>
                            <mml:mrow>
                                <mml:mo stretchy="true">[</mml:mo>
                                <mml:mi>MB</mml:mi>
                                <mml:mo>/</mml:mo>
                                <mml:mi>day</mml:mi>
                                <mml:mo stretchy="true">]</mml:mo>
                            </mml:mrow>
                        </mml:math>

                        <label>(12)</label>
</disp-formula>

                    <disp-formula id="e13">

                        <mml:math display="block">
                            <mml:msub>
                                <mml:mi>C</mml:mi>
                                <mml:mtext mathvariant="italic">year</mml:mtext>
                            </mml:msub>
                            <mml:mo>=</mml:mo>
                            <mml:mn>365</mml:mn>
                            <mml:mo>&#x00d7;</mml:mo>
                            <mml:mi>c</mml:mi>
                            <mml:mo>&#x00d7;</mml:mo>
                            <mml:msub>
                                <mml:mi>D</mml:mi>
                                <mml:mi mathvariant="italic">day</mml:mi>
                            </mml:msub>
                            <mml:mspace width="2em"/>
                            <mml:mrow>
                                <mml:mo stretchy="true">[</mml:mo>
                                <mml:mi>USD</mml:mi>
                                <mml:mo>/</mml:mo>
                                <mml:mtext>year</mml:mtext>
                                <mml:mo stretchy="true">]</mml:mo>
                            </mml:mrow>
                        </mml:math>

                        <label>(13)</label>
</disp-formula>
                </p>
                <p>where 
                    <inline-formula>

                        <mml:math display="inline">
                            <mml:mn>86400</mml:mn>
                            <mml:mspace width="0.25em"/>
                        </mml:math>
</inline-formula>is sec/day, 1024 Bytes/MB, and c is the data tariff. At c=$0.10/MB, CAFE (F=5, D
                    <sub>day</sub>=0.412 MB) versus Statistical baseline (F=8, D
                    <sub>day</sub>=0.659 MB) saves $9.02 annually per patient. Protocol overhead may increase absolute volumes by 20-50
                    <italic toggle="yes">%</italic>
                </p>
            </sec>
            <sec id="sec14">
                <title>3.7 Baseline methods and validation</title>
                <p>The framework tested CAFE on 187 labeled activity recordings (57 fall risk, 130 normal), each 4-s
 long.</p>
                <p>For detection accuracy, five EMG features were extracted: power, mobility, asymmetry, jerkiness, and coupling. Only the first three were transmitted (to save bandwidth), while the last two were computed locally to improve detection. then combined all five into a risk score, optimized the weights, and evaluated the ability of the CAFE to detect fall-risk activities (sensitivity, specificity, F1-score). For the bandwidth comparison, four methods were compared for the same 187 recordings. Both methods extract different types of features, compute a risk score, and choose an optimal threshold, all on the same test data, to be fairly compared to each other, as shown in 
                    <xref ref-type="table" rid="T2">
Table 2</xref>.</p>
                <table-wrap id="T2" orientation="portrait" position="float">
                    <label>
Table 2. </label>
                    <caption>
                        <title>Method comparison for bandwidth efficiency evaluation.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Methods</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Transmitted</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">
Features</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">
Bitrate (kbps)</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">CAF&#x00c9; (this work)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">5 (adapts to 3 at low BW)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Physiological (power, mobility, asymmetry)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.040</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Statistical</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">8</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Mean, std, skewness, kurtosis, max, min, range, MAD</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.064</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Wavelet</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">7</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Frequency coefficients (4-level db4 decomposition)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.056</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="top">Entropy</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">2</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Complexity measures (Shannon entropy)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">0.016</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <p>

                    <bold>For performance metrics;</bold> detection was summarized using 
                    <bold>sensitivity</bold> (recall), 
                    <bold>specificity</bold>, 
                    <bold>precision</bold>, and 
                    <bold>F1-score</bold> (F1 = 2&#x00b7;precision&#x00b7;recall/ (precision+recall)). The 
                    <bold>AUC</bold> (area under the ROC curve (AUC) was then reported for the binary fall risk task. The bandwidth was reported in 
                    <bold>kbps</bold>, and the statistical baseline included the median absolute deviation (MAD) among its eight descriptors. Thresholds were tuned by a grid search on a held-out validation set, and uncertainty was quantified by 
                    <bold>bootstrap resampling</bold> (n = 1,000).</p>
                <p>To measure the detection accuracy: (F1-score), bandwidth used (kbps), and efficiency (F1-score per kbps). Bootstrap resampling for 1000 iterations tested whether the F1-score differences between CAFE and Statistical method were statistically significant or just random variation. The frequency method was excluded because it requires synchronization of multimodal signals from the same person; our dataset has signals from different people.</p>
            </sec>
        </sec>
        <sec id="sec15">
            <title>IV. Results and analysis</title>
            <sec id="sec16">
                <title>4.1 Feature stability and discriminative analysis</title>
                <p>A heterogeneous dataset with 163 participants (128 EEG contributors and 35 EMG/ECG/EOG contributors) was analyzed to provide key insights for implementing deployment in a variety of elderly populations without any calibration. The windows used were 4-s with 50% overlap, which resulted in 77 multimodal windows to be used to determine the initial features and evaluate stability. Feature analysis of 77 windows of 163 heterogeneous subjects showed three stability tiers, as shown in 
                    <xref ref-type="fig" rid="f3">Figure 3</xref>. EMG was found to have high stability (CV &lt; 0.20), mobility (CV=0.083), EEG beta power (CV=0.117), and HR (CV=0.165), taking on a similar cross-subject behavior. Intermediate-stability features EEG slowing ratio, theta, and alpha power were added to (CV 0.28-0.33). The high-variability characteristics (CV= 0.35) encompassed HRV (CV=0.392), EMG power (CV=0.339), and delta power, as shown in 
                    <xref ref-type="table" rid="T3">
Table 3</xref>. Interestingly, highly variable features displayed better discriminative power. The highest discriminative ratio (39.154) was obtained for heart rate, followed by blink rate (27.947), and HRV (25.659), as shown in 
                    <xref ref-type="fig" rid="f3">Figure 3</xref> Panel c. This is because inter-subject differences in baseline do not rule out the possibility of consistent within-subject responses to risk conditions. HRV is a mixed phenomenon, depending on individuals, although change is predictable in individuals when there are risk occurrences. These results support the 5-feature transmission set of CAFE: stable enough to calibrate free deployment but discriminative to detect graph-based coupling features (CV &gt; 0.4) have been filtered off because they are unstable in asynchronous multisubject data.</p>
                <fig fig-type="figure" id="f3" orientation="portrait" position="float">
                    <label>
Figure 3. </label>
                    <caption>
                        <title>Population-level feature analysis across 77 multimodal windows.</title>
                        <p>(A) Distributions (boxplots) of key features (e.g., heart rate, HRV, EEG slowing ratio, EMG power) across subjects.</p>
                        <p>(B) Feature stability quantified by the coefficient of variation (CV), where lower CV indicates greater cross-subject stability.</p>
                        <p>(C) Discriminative ratio (between-class variance divided by within-class variance) indicating separation power between risk and normal windows.</p>
                    </caption>
                    <graphic id="gr3" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/194597/abaf3938-91e4-4367-8f28-85fa4c95f545_figure3.gif"/>
                </fig>
                <table-wrap id="T3" orientation="portrait" position="float">
                    <label>
Table 3. </label>
                    <caption>
                        <title>Population feature statistics across 77 multimodal windows.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Feature</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Mean</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Std</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Min</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Max</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">CV</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">
Units</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Delta Power</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.112</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.038</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.032</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.216</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.336</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">relative</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Theta Power</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.139</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.046</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.062</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.259</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.333</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">relative</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Alpha Power</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.171</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.048</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.088</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.327</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.283</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">relative</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Beta Power</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.578</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.067</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.402</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.772</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.117</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">relative</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Slowing Ratio</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.343</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.100</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.144</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.727</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.290</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">unitless</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">EMG Power</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.447</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.151</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.275</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">1.488</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.339</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">normalized</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">EMG Mobility</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.614</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.051</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.531</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.761</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.083</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">unitless</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Heart Rate*</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">78.9</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">13.0</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">54.7</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">101.7</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.165</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">bpm</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <p>
                    <xref ref-type="fig" rid="f3">Figure 3</xref> shows the population-level feature analysis of, the 77 multimodal windows. (a) Boxplot distributions showing normalized values for heart rate (HR), heart rate variability (HRV), EEG slowing ratio, and EMG power across the heterogeneous population. (b) Feature stability measured by the coefficient of variation (CV), with median CV=0.295, indicated by the red dashed line. A lower CV indicates better cross-subject consistency. (c) Discriminative ratios quantifying each feature's ability to distinguish between risk states, calculated as between-class variance divided by within-class variance.</p>
            </sec>
            <sec id="sec17">
                <title>4.2 Validation and comparative performance</title>
                <p>The evaluation protocol ensured fair comparison across the methods. All approaches were tested on identical 4-s windows with 50% overlap. detection thresholds were optimized via grid search on a held-out validation set (20% of subjects). Statistical comparisons were performed using bootstrap resampling (n = 1,000) with stratified sampling by class label to maintain a balanced representation.</p>
                <p>Independent validation using 187 labeled EMG windows (57 fall risk, 130 normal) compared CAFE with established feature extraction methods. All methods were evaluated on identical windows using the same optimization protocol: the transmitted features were mapped to scalar risk scores via weighted summation with tuned thresholds.</p>
                <p>CAFE scored 70.8% F1 on five features transmitted at 0.040 kbps, which was not statistically significantly different from the 69.8% F1 of the Statistical method with eight features transmitted at 0.064 kbps, as shown in 
                    <xref ref-type="table" rid="T4">
Table 4</xref>. All 1000 iterations of bootstrap resampling showed a difference of 0.93 percentage points (95% CI:[-4.51, 6.43], p=0.393), which was not significant. This shows that the reduction of features by 37.5 percent does not impair clinical efficacy and significantly minimizes transmission requirements.</p>
                <table-wrap id="T4" orientation="portrait" position="float">
                    <label>
Table 4. </label>
                    <caption>
                        <title>Method comparison on labeled EMG windows (n=187).</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Method</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Features</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Processing Time (s)
                                    <sup>a</sup>
                                </th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Bitrate (kbps)</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">F1 Score (%)</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">F1/kbps</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">
F1/s</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">CAFE</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">5</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.089</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.040</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">70.8</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">1769</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">798</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Statistical</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">8</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.236</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.064</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">69.8</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">1091</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">296</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Wavelet</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">7</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.264</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.056</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">46.1</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">823</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">175</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Entropy</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">2</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.039</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.016</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">46.1</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">2881</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">1197</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <p>The low effectiveness of wavelet (46.1%) and entropy (46.1%) algorithms is due to their use of frequency decomposition and statistical parameters that are incapable of capturing the time-dependent variation that is essential in fall detection. These techniques encode signal data using spectral coefficients or entropy values, discarding the temporal patterns used to differentiate between fall risk and normal events.</p>
                <p>The Wavelet and Entropy methods were not successful in this study because there were basic differences in the design and requirements of the detection task. Wavelet Transform records the change in frequencies on the time scales but fails to capture fine-temporal dynamics that are critical in identifying brief events such as falls that are usually less than 2 s in duration and shorter than the 4-second analysis window. Similarly, Entropy-based features are sensitive to noise and window length, which causes instability in real-time monitoring. In contrast, CAFE chose time-domain and physiological characteristics (EMG power, mobility, asymmetry, heart rate, and EEG slowing ratio) that directly capture the rapid transients of elderly health events, such as fall-related muscle bursts.</p>
                <p>Although the Entropy technique has better in bandwidth efficiency (2881 F1/kbps) because it does not transmit many features, its absolute F1 value of 46.1% is lower than the clinical acceptability levels of fall detectors. This reflects the essential difference between efficiency measures and clinical usefulness, with bandwidth optimization detrimental to clinical utility. The best balance is obtained by CAFE: 62 percent higher bandwidth efficiency than statistical (1769 vs 1091 F1/kbps) and clinical accuracy, as shown in 
                    <xref ref-type="fig" rid="f4">Figure 4</xref>.</p>
                <fig fig-type="figure" id="f4" orientation="portrait" position="float">
                    <label>
Figure 4. </label>
                    <caption>
                        <title>Comparative method performance.</title>
                        <p>F1 scores showing CAFE (70.8%) and Statistical (69.8%) methods substantially outperforming Wavelet and Entropy approaches (both 46.1%).</p>
                    </caption>
                    <graphic id="gr4" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/194597/abaf3938-91e4-4367-8f28-85fa4c95f545_figure4.gif"/>
                </fig>
                <p>The total computation time of the test batch with a 187-window test was the processing time; the common variation between the test runs was &#x00b1;15 percent, with a load on the system. F1 scores were fixed random variables. The Frequency method was excluded because of its incompatibility with asynchronous multi-subject data. The performance of the comparative method showing CAFE (70.8%) and statistical (69.8%) substantially outperformed Wavelet and Entropy approaches (both 46.1%). Bootstrap resampling (n=1000) confirmed CAFE and Statistical methods were not statistically significantly different (&#x0394;F1=0.93 pp, 95% CI [-4.51, 6.43], p=0.393), which indicates that 37.5% reduction in features does not affect the accuracy of detection, but the transmission requirements are significantly decreased.</p>
                <p>In addition to the bandwidth efficiency comparison discussed above, CAFE's clinical detection capability of CAFE was proved through the binary fall risk classification on the same 187 labeled EMG windows. Activities were grouped into fall-risk (bowing, jumping, running) versus normal (sitting, standing, walking), achieving F1 = 57.8%, sensitivity = 64.9%, specificity = 73.8%, AUC = 0.70, as shown in 
                    <xref ref-type="fig" rid="f5">Figure 5</xref>. This binary classification result differs from the composite scoring F1 (70.8%) reported in 
                    <xref ref-type="table" rid="T4">
Table 4</xref> because they measure different assignments; binary classification evaluates a single clinical detection problem with ground truth labels, whereas combined scoring integrates all five features to compare bandwidth efficiency across all methods.</p>
                <fig fig-type="figure" id="f5" orientation="portrait" position="float">
                    <label>
Figure 5. </label>
                    <caption>
                        <title>ROC curve for binary fall risk detection.</title>
                        <p>(AUC) = 0.70.</p>
                    </caption>
                    <graphic id="gr5" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/194597/abaf3938-91e4-4367-8f28-85fa4c95f545_figure5.gif"/>
                </fig>
                <p>To determine the framework for multi-domain monitoring beyond the fall risk, a separate dataset of 77 multimodal windows (EEG, ECG, and EMG from different subjects) was analyzed using population adaptive thresholds. CAFE detected 32 events across three health domains, as shown in 
                    <xref ref-type="table" rid="T5">
Table 5</xref>: five cardiac events (6.5%, HR &lt;50 or &gt;100 bpm), 15 cognitive events (19.5%, EEG slowing &gt;80th percentile), and 12 fall-risk events (15.6%, EMG power &gt;85th percentile). Only fall risk detection has been validated against ground truth labels; cardiac and cognitive detection uses clinically established thresholds, but requires future validation with labeled datasets such as the MIT-BIH arrhythmia database and standardized cognitive assessments.</p>
                <table-wrap id="T5" orientation="portrait" position="float">
                    <label>
Table 5. </label>
                    <caption>
                        <title>Clinical event detection summary across 77 monitoring windows.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Event Type</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Count</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Percentage (%)</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Priority Level</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Detection Criteria</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Cardiac</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">5</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">6.5%</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">HIGH</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">HR &lt;50 or &gt;100 bpm; HRV &lt;20 ms</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Cognitive</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">15</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">19.5%</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">MEDIUM</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">EEG slowing ratio &gt;80th percentile</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Fall Risk</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">12</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">15.6%</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">HIGH</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">EMG power &gt;85th percentile</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">
                                    <bold>Total Events</bold>
</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">
                                    <bold>32</bold>
</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">
                                    <bold>41.6%</bold>
</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">-</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">-</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <p>To our knowledge, CAFE is the first framework that explicitly optimizes bandwidth (0.040 kbps, 37.5% reduction) and simultaneously monitors three health domains across 163 subjects without requiring individual calibration. 
                    <xref ref-type="table" rid="T4">
Table 4</xref> shows that CAFE allows deployment in bandwidth-constrained environments, such as emergency response scenarios and rural clinics, while maintaining no statistically significant difference from higher bitrate techniques (p=0.393). In addition, the direct comparison is limited because prior works report accuracy, whereas CAFE reports the F1-score, a stricter metric that accounts for class imbalance. The comparison with specific researches is summarized in 
                    <xref ref-type="table" rid="T6">
Table 6</xref>.</p>
                <table-wrap id="T6" orientation="portrait" position="float">
                    <label>
Table 6. </label>
                    <caption>
                        <title>Comparison of CAFE with related frameworks.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Framework</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Year</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Primary Focus</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Metric</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Key Metrics</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Bandwidth Reported</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Chen et al.
                                    <sup>
                                        <xref ref-type="bibr" rid="ref2">2</xref>
                                    </sup>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">2018</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Edge cognitive computing</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">-</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Resource allocation</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">No</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Alshuhail et al.
                                    <sup>
                                        <xref ref-type="bibr" rid="ref3">3</xref>
                                    </sup>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">2025</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Real-time edge AI for cardiac + fall</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Accuracy</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">95.4%</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">No</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Oladunni &amp; Wong
                                    <sup>
                                        <xref ref-type="bibr" rid="ref21">21</xref>
                                    </sup>
                                </td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">2025</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Multimodal ECG feature fusion (complementarity)</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">Accuracy</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">96%</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">No</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">CAFE (This work)</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">2025</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Bandwidth-optimized multi-domain monitoring</td>
                                <td align="left" colspan="1" rowspan="1" valign="top">F1-score</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">70.8%</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">Yes (0.040 kbps, 37.5% reduction)</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
            </sec>
            <sec id="sec18">
                <title>4.3 Bandwidth adaptivity and robustness</title>
                <p>Method comparison of 187 labeled EMG windows. Processing time refers to the total computation for the full test batch. F1/kbps measures the bandwidth efficiency (higher is better), and F1/s measures the computational efficiency of CAFE's adaptive transmission mechanism using the rate model in 
                    <xref ref-type="disp-formula" rid="e10 e11">Equations (10)&#x2013; (11)</xref>, it responds dynamically to the available bandwidth, enabling deployment within heterogeneous network conditions from urban 5G to rural 2G connections. 
                    <xref ref-type="fig" rid="f6">Figure 6</xref> shows this adaptability through feature scaling and performance under the bandwidth constraint.</p>
                <fig fig-type="figure" id="f6" orientation="portrait" position="float">
                    <label>
Figure 6. </label>
                    <caption>
                        <title>Bandwidth efficiency analysis (A) Adaptive Feature Transmission (the modified dashboard subplot), (B) Performance Under Bandwidth Constraints (your F1 vs bandwidth graph).</title>
                    </caption>
                    <graphic id="gr6" orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/194597/abaf3938-91e4-4367-8f28-85fa4c95f545_figure6.gif"/>
                </fig>
                <p>
                    <xref ref-type="fig" rid="f6">Figure 6</xref> -panel (a) shows CAFE grading from the 3 essential features (HR, EMG power, EEG slowing) at 0.5 kbps to all 5-feature set at B
                    <sub>avail</sub> &#x2265;2.0 kbps, compared to the Statistical baseline's fixed 8-feature requirement. The 
                    <xref ref-type="table" rid="T7">
Table 7</xref> describes this adaptation: at minimal bandwidth (0.5 kbps), CAFE transmits only the three features with highest stability and discriminative power, maintaining core detection capability at 0.024 kbps (4.8% utilization). Then when bandwidth increases, CAFE adds complementary features (EMG mobility at 1.0 kbps, asymmetry at 2.0 kbps) to achieve its full detection performance of 70.8% F1 at 0.040 kbps.</p>
                <table-wrap id="T7" orientation="portrait" position="float">
                    <label>
Table 7. </label>
                    <caption>
                        <title>Bandwidth-adaptive feature transmission analysis.</title>
                    </caption>
                    <table content-type="article-table" frame="hsides">
                        <thead>
                            <tr>
                                <th align="left" colspan="1" rowspan="1" valign="top">Bandwidth (kbps)</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Features Transmitted</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">Actual Bitrate (kbps)</th>
                                <th align="left" colspan="1" rowspan="1" valign="top">
Utilization (%)</th>
                            </tr>
                        </thead>
                        <tbody>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.5</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">3 (HR, EMG_P, Slowing)</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.024</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">4.8</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">1.0</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">4 (+EMG_Mobility)</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.032</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">3.2</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">2.0</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">5 (+Asymmetry)</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.040</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">2.0</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">5.0</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">5 (maximum)</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.040</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.8</td>
                            </tr>
                            <tr>
                                <td align="left" colspan="1" rowspan="1" valign="middle">10.0</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">5 (maximum)</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.040</td>
                                <td align="left" colspan="1" rowspan="1" valign="middle">0.4</td>
                            </tr>
                        </tbody>
                    </table>
                </table-wrap>
                <p>Then in 
                    <xref ref-type="fig" rid="f6">Figure 6</xref>, panel(b) shows the robustness of CAFE when the bandwidth falls below the design specifications. At CAFE's operating point of 40 bits per second, it will achieve the full detection performance (70.8% F1), while the statistical method forced to operate below its 64-bps requirement that&#x2019;s leads to degradation to approximately 44% F1 as a result of insufficient bandwidth for its eight feature transmissions. The Statistical method requires approximately 80 bps (double the CAFE requirement) to recover a comparable detection performance. This 2&#x00d7; bandwidth advantage is critical for employment in bandwidth-limited situations, such as intermittent satellite links, congested emergency networks, or rural 2G infrastructure operating near capacity.</p>
                <p>And to analyze the capacity and economic implications, a bandwidth reduction 37.5% and a single 2G gateway with 9.6 kbps bandwidth with 0.040 kbps per patient then it can support 240 CAFE patients against 150 using statistical methods that support 60% more patients per gateway due to CAFE's lower 0.040 kbps per patient requirement. Using the daily data model as calculated in Equations 
                    <xref ref-type="disp-formula" rid="e12 e13">(12) and (13)</xref>, CAFE achieved 0.412 MB/day versus 0.659 MB/day for Statistical baseline. In rural data pricing (c=$0.10/MB), this yields $9.02 annual savings per patient or $902 for a 100-patient clinic, while reducing the infrastructure requirements by one gateway for 300 patients.</p>
            </sec>
            <sec id="sec19">
                <title>4.4 Discussion and practical implications</title>
                <p>The main limitations can be summarized after the results analysis as: First, there was only mobility detection tested on ground-truth activity labels; cardiac (6.5% event rate) and cognitive monitoring (19.5% event rate) are still exploratory with population-adaptive thresholds. Second, the subjects and the sessions were different (asynchronous) MU data, which does not allow inter-modal coupling analysis to be performed reliably. Graph-based and coherence features were highly unstable when (CV&gt;0.4) and under these conditions can be useful in simultaneous same-subject recordings. Third, validation used controlled activity classifications (bowing, jumping, sitting, etc.) rather than real-world fall events. Fourth, the thresholds were optimized in the test corpus and external testing was required. Finally, overheads in network protocols and packet loss robustness were not empirically tested. The practical implication of the framework is in aspects such as Iraq, where both represent data and monitoring infrastructure that can be constrained by a stimulus and an obstacle to this work. The low-bandwidth delivery-specific requirements of CAFE (0.040 kbps) were created within these resource-constrained environments. Nevertheless, externally validated living with locally gathered datasets or pilot studies in Iraqi evidence would be reinforced by the applicability of healthcare facilities.</p>
            </sec>
        </sec>
        <sec id="sec20" sec-type="conclusion">
            <title>V. Conclusion</title>
            <p>This study introduced CAFE, which is a bandwidth-efficient structure for multi-domain elderly health monitoring. The method scored 70.8% F1-score and also reduced transmission by 37.5% over an 8-feature baseline, and cross-subject generalization in 163 heterogeneous subjects without subject-specific calibration. The difference from statistical baseline was non-significant on labeled EMG windows (&#x0394;F1 = 0.93 percentage points; 95% CI[-4.51, 6.43]; p = 0.393) and bandwidth reduction did not affect detection performance in detection.</p>
            <p>These findings indicate the possibility of efficient multi-domain monitoring, even in bandwidth-constrained rural and resource-limited environments. The feature selection method provides effective advice on the design of systems with a trade-off between detection and communication costs, and the adaptive transmission mechanism facilitates smooth performance in the presence of variable connectivity.</p>
            <p>The present limitations are that validation with larger clinical datasets and usability testing in areas with limited infrastructure are required. Further work will involve the integration of more physiological indicators, deployment-based adaptive learning of threshold data, and pilot studies on resource-constrained environments.</p>
        </sec>
    </body>
    <back>
        <sec id="sec23" sec-type="data-availability">
            <title>Data availability</title>
            <sec id="sec24">
                <title>Underlying data</title>
                <p>The datasets used in this study are publicly available from the following repositories:
                    <list list-type="order">
                        <list-item>
                            <label>1.</label>
                            <p>EEG Dataset: Kaggle. 
                                <ext-link ext-link-type="uri" xlink:href="https://www.kaggle.com/datasets/amananandrai/complete-eeg-dataset">https://www.kaggle.com/datasets/amananandrai/complete-eeg-dataset</ext-link>
                                <sup>
                                    <xref ref-type="bibr" rid="ref41">41</xref>
                                </sup>
                            </p>
                        </list-item>
                        <list-item>
                            <label>2.</label>
                            <p>EMG Physical Action Data Set: UCI Machine Learning Repository. 
                                <ext-link ext-link-type="uri" xlink:href="https://archive.ics.uci.edu/dataset/213/emg+physical+action+data+set">https://archive.ics.uci.edu/dataset/213/emg+physical+action+data+set</ext-link> (DOI: 
                                <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.24432/C53W49">https://doi.org/10.24432/C53W49</ext-link>)
                                <sup>
                                    <xref ref-type="bibr" rid="ref42">42</xref>
                                </sup>
                            </p>
                        </list-item>
                        <list-item>
                            <label>3.</label>
                            <p>EOG Data: Fang, F., &amp; Shinozaki, T. (2020). Eye-tracking (EOG) Data. Zenodo. 
                                <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.5281/zenodo.4288977">https://doi.org/10.5281/zenodo.4288977</ext-link>
                                <sup>
                                    <xref ref-type="bibr" rid="ref43">43</xref>
                                </sup>
                            </p>
                        </list-item>
                        <list-item>
                            <label>4.</label>
                            <p>Zenodo. CAFE Framework - Biosignal Data for Elderly Monitoring. 
                                <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.5281/zenodo.18235368">https://doi.org/10.5281/zenodo.18235368</ext-link>
                                <sup>
                                    <xref ref-type="bibr" rid="ref44">44</xref>
                                </sup>
                            </p>
                        </list-item>
                    </list>
                </p>
                <p>This project contains the following extended data:
                    <list list-type="bullet">
                        <list-item>
                            <label>&#x2022;</label>
                            <p>
ECG_Preprocessed_Data.csv (preprocessed ECG signals used in the analysis)</p>
                        </list-item>
                    </list>
                </p>
                <p>Data are available under the terms of the 
                    <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International license</ext-link> (CC-BY 4.0).</p>
            </sec>
        </sec>
        <ack>
            <title>Acknowledgments</title>
            <p>The authors thank the University of Mustansiriyah and Biomedical Engineering Research Center at the University of Anbar for their assistance. Special thanks are given to colleagues at both universities for their support, advice, and encouragement. The authors thank the anonymous reviewers for their useful comments, which have greatly improved the quality of this paper.</p>
        </ack>
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