<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN" "http://jats.nlm.nih.gov/publishing/1.2/JATS-journalpublishing1.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="case-report" dtd-version="1.2" xml:lang="en">
    <front>
        <journal-meta>
            <journal-id journal-id-type="pmc">F1000Research</journal-id>
            <journal-title-group>
                <journal-title>F1000Research</journal-title>
            </journal-title-group>
            <issn pub-type="epub">2046-1402</issn>
            <publisher>
                <publisher-name>F1000 Research Limited</publisher-name>
                <publisher-loc>London, UK</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="doi">10.12688/f1000research.5689.1</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Case Report</subject>
                </subj-group>
                <subj-group>
                    <subject>Articles</subject>
                    <subj-group>
                        <subject>Child &amp; Adolescent Psychiatry</subject>
                    </subj-group>
                    <subj-group>
                        <subject>Developmental &amp; Pediatric Neurology</subject>
                    </subj-group>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Case Report: "ADHD Trainer": the mobile application that enhances cognitive skills in ADHD patients</article-title>
                <fn-group content-type="pub-status">
                    <fn>
                        <p>[version 1; peer review: 1 approved with reservations]</p>
                    </fn>
                </fn-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Ruiz-Manrique</surname>
                        <given-names>Gonzalo</given-names>
                    </name>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="yes">
                    <name>
                        <surname>Tajima-Pozo</surname>
                        <given-names>Kazuhiro</given-names>
                    </name>
                    <xref ref-type="corresp" rid="c1">a</xref>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Monta&#x00f1;es-Rada</surname>
                        <given-names>Francisco</given-names>
                    </name>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <aff id="a1">
                    <label>1</label>Department of Psychiatry, Hospital Universitario Fundacion Alcorcon, Alcorcon, 28922, Spain</aff>
            </contrib-group>
            <author-notes>
                <corresp id="c1">
                    <label>a</label>
                    <email xlink:href="mailto:kazutajima@hotmail.com">kazutajima@hotmail.com</email>
                </corresp>
                <fn fn-type="con">
                    <p>Dr. Gonzalo Ruiz wrote the manuscript, supervised by Dr. Kazuhiro Tajima-Pozo and Dr. Francisco Monta&#x00f1;es-Rada. All authors agreed to the final content of the manuscript.</p>
                </fn>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>Dr. Kazuhiro Tajima-Pozo, participated in the development of &amp;ldquo;ADHD Trainer&amp;rdquo;, and other mental health applications at TKT Brain Solutions, which is a Spanish startup, integrated by medical doctors and engineers, whose aim is to develop mental health applications.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>18</day>
                <month>11</month>
                <year>2014</year>
            </pub-date>
            <pub-date pub-type="collection">
                <year>2014</year>
            </pub-date>
            <volume>3</volume>
            <elocation-id>283</elocation-id>
            <history>
                <date date-type="accepted">
                    <day>14</day>
                    <month>11</month>
                    <year>2014</year>
                </date>
            </history>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2014 Ruiz-Manrique G et al.</copyright-statement>
                <copyright-year>2014</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <self-uri content-type="pdf" xlink:href="https://f1000research.com/articles/3-283/pdf"/>
            <abstract>
                <p>We report the case of a 10 year old patient diagnosed with attention deficit hyperactivity disorder (ADHD) and comorbid video game addiction, who was treated with medication combined to a novel cognitive training method based on video games called TCT method. A great risk of developing video game or internet addiction has been reported in children, especially in children with ADHD. Despite this risk, we hypothesize that the good use of these new technologies might be useful to develop new methods of cognitive training. The cognitive areas in which a greater improvement was observed through the use of video games were the visuospatial working memory and fine motor skills. TCT method is a cognitive training method that enhances cognitive skills such as attention, working memory, processing speed, calculation ability, reasoning, and visuomotor coordination. The purpose of reviewing this case is to highlight that regular cognitive computerized training in ADHD patients can improve some of their cognitive symptoms and can help treating video game addition.</p>
            </abstract>
            <kwd-group kwd-group-type="author">
                <kwd>ADHD; mobile app; TCT method; working memory</kwd>
            </kwd-group>
            <funding-group>
                <funding-statement>The author(s) declared that no grants were involved in supporting this work.</funding-statement>
            </funding-group>
        </article-meta>
    </front>
    <body>
        <sec sec-type="intro">
            <title>Introduction</title>
            <p>Attention deficit hyperactivity disorder (ADHD) is the most commonly diagnosed neurodevelopmental disorder in childhood, which affects 3% to 7% of the population worldwide
                <sup>
                    <xref ref-type="bibr" rid="ref-1">1</xref>
                </sup>. ADHD is characterized by distractibility, hyperactivity and impulsivity. The standard treatment for ADHD includes mainly medication, psychosocial and behavioral treatment, and cognitive training exercises.</p>
            <p>Cognitive training exercises are especially useful when cognitive impairment is observed and when a regular and personalized cognitive training is performed
                <sup>
                    <xref ref-type="bibr" rid="ref-2">2</xref>
                </sup>. Studies in participants with cognitive impairment have shown that regular and daily cognitive training can improve some of their cognitive symptoms
                <sup>
                    <xref ref-type="bibr" rid="ref-3">3</xref>,
                    <xref ref-type="bibr" rid="ref-4">4</xref>
                </sup>. In addition, recent studies have demonstrated that computerized working memory and executive function training programs lead to better results than ordinary cognitive training methods in children with ADHD
                <sup>
                    <xref ref-type="bibr" rid="ref-5">5</xref>&#x2013;
                    <xref ref-type="bibr" rid="ref-7">7</xref>
                </sup>.</p>
            <p>Children&#x2019;s use of electronic devices, Internet and video games, has noticeably increased in the last 10 years. Since the first case of Internet addiction was described in 1996 by Young
                <sup>
                    <xref ref-type="bibr" rid="ref-6">6</xref>
                </sup>, several other pathologies have been proposed including pathological gambling and dependence
                <sup>
                    <xref ref-type="bibr" rid="ref-7">7</xref>
                </sup>. Despite extensive research literature available, the prevalence and proper diagnostic criteria for pathological gaming are still debated among the scientific community
                <sup>
                    <xref ref-type="bibr" rid="ref-8">8</xref>
                </sup>. Gaming addiction represents part of the postulated construct of Internet addiction, and is the most widely studied specific form of Internet addiction to date
                <sup>
                    <xref ref-type="bibr" rid="ref-9">9</xref>
                </sup>. Prevalence estimates range from 2%
                <sup>
                    <xref ref-type="bibr" rid="ref-10">10</xref>
                </sup> to 15%
                <sup>
                    <xref ref-type="bibr" rid="ref-11">11</xref>
                </sup>, depending on the respective socio-cultural context, sample, and assessment criteria utilized. A great risk of developing video game or Internet addiction has been reported in children, and especially in those with ADHD
                <sup>
                    <xref ref-type="bibr" rid="ref-8">8</xref>
                </sup>. Despite this risk, we hypothesize that good use of these new technologies can be useful to develop new methods of cognitive training.</p>
        </sec>
        <sec sec-type="cases">
            <title>Case report</title>
            <p>This case study involves a 10 year old child born in Madrid (Spain) who received treatment in a childhood psychiatry unit for 2 years due to behavioral disorders and ADHD. No other previous medical history was reported. His mother, aged 35, received psychological treatment for anxiety 3 years ago. His father, aged 36, works as an engineer and presented no relevant medical history. The patient was their only son. The parents described a great addiction to video games in the last year, a, referring 4 hours per day of video game playing, affecting his social interaction, and causing a lack of imaginative play and poor academic scores. Teachers at the school reported deterioration in his academic performance over the past year. At that time, the child was treated with methylphenidate 40 mg per day. The patient&#x2019;s parents reported to the psychiatrist that the only significant change from the previous year was a major addiction to a war videogame.</p>
            <p>To reduce the exposure to video games, we used a novel technique, cognitive stimulation with a mobile/tablet application designed specifically to treat ADHD, based on the method of Tajima Cognitive Method (TCT) cognitive training called &#x201c;ADHD Trainer&#x201d;.</p>
            <p>Behavioral and academic improvements were rated on the Conners Parent and Teacher Rating Scales (brief version) and Barkley School Situations Questionnaire.</p>
            <p>ADHD diagnosis was made according to DSM V criteria
                <sup>
                    <xref ref-type="bibr" rid="ref-9">9</xref>,
                    <xref ref-type="bibr" rid="ref-10">10</xref>
                </sup>. Attention was rated with CPT Conners Continuous Performance Test.</p>
            <p>A differential diagnosis between oppositional defiant disorder and ADHD disorder was considered, because most of the symptoms were observed at home, however not angry or irritable mood was observed.</p>
            <p>The patient was treated with a combination of methylphenidate and a cognitive training method based in the TCT method. The patient received daily treatment with 40 mg of methylphenidate, and at least 10 minutes of daily cognitive training with the &#x201c;ADHD Trainer&#x201d; app.</p>
            <p>The TCT is a type of computer adaptive test (CAT), as it adapts to the individual&#x2019;s cognitive strengths and weaknesses, based on his own scores over time, as well as those of his peers. Users receive separate scores in different cognitive areas, including simple calculation, attention, perceptual reasoning, and visuomotor coordination (
                <xref ref-type="fig" rid="f1">Figure 1</xref>). The goal of the daily training is to reach a pre-set individualized score in different cognitive domains, in order to complete a week of successful training</p>
            <fig fig-type="figure" id="f1" orientation="portrait" position="float">
                <label>Figure 1. </label>
                <caption>
                    <title>The cognitive areas treated with ADHD Trainer.</title>
                </caption>
                <graphic orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/6082/b60f6b3f-75a6-4b11-938e-5b7ba66918bd_figure1.gif"/>
            </fig>
            <p>During the first month of cognitive training therapy, the patient was only allowed to play with specific games based on the TCT Method, using the &#x201c;ADHD Trainer&#x201d; (
                <xref ref-type="fig" rid="f2">Figure 2</xref>). The patient had to use the app every day at the same time, provided the other targets that were assigned in therapy, such as the progressive reduction in the number of hours to play other games and just being able to play with them once a week, were met. During the first month, he was allowed to play this game to a maximum range of 4 hours per day. No addiction to this videogame was observed during the first month. The average number of hours that the child played the video game was 1 hour a day. In the following months the objective was to play the game at least 10 minutes per day.</p>
            <fig fig-type="figure" id="f2" orientation="portrait" position="float">
                <label>Figure 2. </label>
                <caption>
                    <title>Capture of one of the games based in Trail Making Test.</title>
                </caption>
                <graphic orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/6082/b60f6b3f-75a6-4b11-938e-5b7ba66918bd_figure2.gif"/>
            </fig>
            <p>In less than two months the video games abuse was substantially reduced, limiting their use to weekends, and always for periods not exceeding 4 hours in total.</p>
            <p>Behavioral and academic improvement was rated on the Conners Parent and Teacher Rating Scales and Barkley School Situations Questionnaire. The initial score of the Conners was 19 for the teachers and 20 for the parents, and after the cognitive training the scores were 15 for the teachers and 16 for the parents.</p>
            <p>Both the school and the family reported a significant improvement in the patient after 6 months of TCT cognitive training, which included important improvements of both academic and behavioral outcomes.</p>
        </sec>
        <sec sec-type="discussion">
            <title>Discussion</title>
            <p>Most of the studies reported so far emphasize the potential addictive risk of new technologies and the influence they have on children's interpersonal development, by reducing the time children spend outside home and increasing the time they spend alone playing in front of a television or a computer screen
                <sup>
                    <xref ref-type="bibr" rid="ref-12">12</xref>&#x2013;14</sup>. It is also known that the new technologies may affect children's academic performance by reducing the number of hours that they dedicate to studying.</p>
            <p>There are few studies which focus on the positive aspects of new technologies and the opportunities that they offer new ways of interaction between professionals and users as well as the development of new therapeutic methods, capable of reaching the young.</p>
            <p>New technologies, in particular video games, can be used as therapeutic tools to train executive functions
                <sup>
                    <xref ref-type="bibr" rid="ref-6">6</xref>,
                    <xref ref-type="bibr" rid="ref-7">7</xref>
                </sup>. As they generate greater motivation in children and adolescents they will increase the frequency of performing cognitive tasks oriented to enhance executive functions, especially the working memory.</p>
            <p>There are key advantages for children practicing the TCT Method relative to traditional cognitive training therapies which include:</p>
            <list list-type="bullet">
                <list-item>
                    <label>1)</label>
                    <p>Increased motivation in children for completing cognitive training therapy. This increase in motivation comes from: entertainment value (these games are designed to be similar to regular video games that children enjoy) and feedback on performances relative to own and peer scores (which improves children&#x2019;s sense of agency and self-efficacy, as demonstrated by documented research on motivation and learning)
                        <sup>
                            <xref ref-type="bibr" rid="ref-11">11</xref>,
                            <xref ref-type="bibr" rid="ref-12">12</xref>
                        </sup>.</p>
                </list-item>
                <list-item>
                    <label>2)</label>
                    <p>Ease of accessing the application. Children can play the games at any place or time, day and night.</p>
                </list-item>
            </list>
        </sec>
        <sec sec-type="conclusions">
            <title>Conclusion</title>
            <p>ADHD patients are especially vulnerable to develop video gaming addition. ADHD patients often suffer from working memory and executive function dysfunctions, but we have observed that very few cognitive training techniques have been developed for ADHD patients in the last years. Poor completion rates of cognitive training in children with ADHD have been observed. We conclude that a daily cognitive computerized training in ADHD patients can improve some of their cognitive symptoms, and can help treating the video gaming addition.</p>
        </sec>
        <sec>
            <title>Consent</title>
            <p>Written informed consent to publish this report was obtained by the patient&#x2019;s parents.</p>
            <p>Dr. Tajima takes responsibility for the integrity of the data and informed consent.</p>
        </sec>
    </body>
    <back>
        <ref-list>
            <ref id="ref-1">
                <label>1</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">
						
                        <name name-style="western">
                            <surname>Weinstein</surname>
                            <given-names>A</given-names>
                        </name>
						
                        <name name-style="western">
                            <surname>Weizman</surname>
                            <given-names>A</given-names>
                        </name>
					</person-group>:
                    <article-title>Emerging association between addictive gaming and attention-deficit/hyperactivity disorder.</article-title>
                    <source>
						
                        <italic toggle="yes">Curr Psychiatry Rep.</italic>
					</source>
                    <year>2012</year>;<volume>14</volume>(<issue>5</issue>):<fpage>590</fpage>&#x2013;<lpage>7</lpage>.
                    <pub-id pub-id-type="pmid">22843540</pub-id>
                    <pub-id pub-id-type="doi">10.1007/s11920-012-0311-x</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref-2">
                <label>2</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">
						
                        <name name-style="western">
                            <surname>Martinussen</surname>
                            <given-names>R</given-names>
                        </name>
						
                        <name name-style="western">
                            <surname>Hayden</surname>
                            <given-names>J</given-names>
                        </name>
						
                        <name name-style="western">
                            <surname>Hogg-Johnson</surname>
                            <given-names>S</given-names>
                        </name>
						
                        <etal/>
					</person-group>:
                    <article-title>A meta-analysis of working memory impairments in children with attention-deficit/hyperactivity disorder.</article-title>
                    <source>
						
                        <italic toggle="yes">J Am Acad Child Adolesc Psychiatry.</italic>
					</source>
                    <year>2005</year>;<volume>44</volume>(<issue>4</issue>):<fpage>377</fpage>&#x2013;<lpage>84</lpage>.
                    <pub-id pub-id-type="pmid">15782085</pub-id>
                    <pub-id pub-id-type="doi">10.1097/01.chi.0000153228.72591.73</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref-3">
                <label>3</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">
						
                        <name name-style="western">
                            <surname>Voelbel</surname>
                            <given-names>G</given-names>
                        </name>
						
                        <name name-style="western">
                            <surname>Ceceli</surname>
                            <given-names>A</given-names>
                        </name>
						
                        <name name-style="western">
                            <surname>Georgieva</surname>
                            <given-names>S</given-names>
                        </name>
						
                        <etal/>
					</person-group>:
                    <article-title>C-40Computerized Neuroplasticity Training Increases Processing Speed of Verbal Information: A Pilot Study of Adults with Traumatic Brain Injury.</article-title>
                    <source>
						
                        <italic toggle="yes">Arch Clin Neuropsychol.</italic>
					</source>
                    <year>2014</year>;<volume>29</volume>(<issue>6</issue>):<fpage>589</fpage>.
                    <pub-id pub-id-type="pmid">25176883</pub-id>
                    <pub-id pub-id-type="doi">10.1093/arclin/acu038.221</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref-4">
                <label>4</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">
						
                        <name name-style="western">
                            <surname>Jungblut</surname>
                            <given-names>M</given-names>
                        </name>
						
                        <name name-style="western">
                            <surname>Huber</surname>
                            <given-names>W</given-names>
                        </name>
						
                        <name name-style="western">
                            <surname>Mais</surname>
                            <given-names>C</given-names>
                        </name>
						
                        <etal/>
					</person-group>:
                    <article-title>Paving the way for speech: voice-training-induced plasticity in chronic aphasia and apraxia of speech--three single cases.</article-title>
                    <source>
						
                        <italic toggle="yes">Neural Plast.</italic>
					</source>
                    <year>2014</year>;<volume>2014</volume>:<fpage>841982</fpage>.
                    <pub-id pub-id-type="pmid">24977055</pub-id>
                    <pub-id pub-id-type="doi">10.1155/2014/841982</pub-id>
                    <pub-id pub-id-type="pmcid">4058170</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref-5">
                <label>5</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">
						
                        <name name-style="western">
                            <surname>Shaw</surname>
                            <given-names>R</given-names>
                        </name>
						
                        <name name-style="western">
                            <surname>Grayson</surname>
                            <given-names>A</given-names>
                        </name>
						
                        <name name-style="western">
                            <surname>Lewis</surname>
                            <given-names>V</given-names>
                        </name>
					</person-group>:
                    <article-title>Inhibition, ADHD, and computer games: the inhibitory performance of children with ADHD on computerized tasks and games.</article-title>
                    <source>
						
                        <italic toggle="yes">J Atten Disord.</italic>
					</source>
                    <year>2005</year>;<volume>8</volume>(<issue>4</issue>):<fpage>160</fpage>&#x2013;<lpage>8</lpage>.
                    <pub-id pub-id-type="pmid">16110046</pub-id>
                    <pub-id pub-id-type="doi">10.1177/1087054705278771</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref-6">
                <label>6</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">
						
                        <name name-style="western">
                            <surname>Bioulac</surname>
                            <given-names>S</given-names>
                        </name>
						
                        <name name-style="western">
                            <surname>Arfi</surname>
                            <given-names>L</given-names>
                        </name>
						
                        <name name-style="western">
                            <surname>Bouvard</surname>
                            <given-names>MP</given-names>
                        </name>
					</person-group>:
                    <article-title>Attention deficit/hyperactivity disorder and video games: a comparative study of hyperactive and control children.</article-title>
                    <source>
						
                        <italic toggle="yes">Eur Psychiatry.</italic>
					</source>
                    <year>2008</year>;<volume>23</volume>(<issue>2</issue>):<fpage>134</fpage>&#x2013;<lpage>41</lpage>.
                    <pub-id pub-id-type="pmid">18206354</pub-id>
                    <pub-id pub-id-type="doi">10.1016/j.eurpsy.2007.11.002</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref-7">
                <label>7</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">
						
                        <name name-style="western">
                            <surname>Lim</surname>
                            <given-names>CG</given-names>
                        </name>
						
                        <name name-style="western">
                            <surname>Lee</surname>
                            <given-names>TS</given-names>
                        </name>
						
                        <name name-style="western">
                            <surname>Guan</surname>
                            <given-names>C</given-names>
                        </name>
						
                        <etal/>
					</person-group>:
                    <article-title>Effectiveness of a brain-computer interface based programme for the treatment of ADHD: a pilot study.</article-title>
                    <source>
						
                        <italic toggle="yes">Psychopharmacol Bull.</italic>
					</source>
                    <year>2010</year>;<volume>43</volume>(<issue>1</issue>):<fpage>73</fpage>&#x2013;<lpage>82</lpage>.
                    <pub-id pub-id-type="pmid">20581801</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref-8">
                <label>8</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">
						
                        <name name-style="western">
                            <surname>Walther</surname>
                            <given-names>B</given-names>
                        </name>
						
                        <name name-style="western">
                            <surname>Morgenstern</surname>
                            <given-names>M</given-names>
                        </name>
						
                        <name name-style="western">
                            <surname>Hanewinkel</surname>
                            <given-names>R</given-names>
                        </name>
					</person-group>:
                    <article-title>Co-occurrence of addictive behaviours: personality factors related to substance use, gambling and computer gaming.</article-title>
                    <source>
						
                        <italic toggle="yes">Eur Addict Res.</italic>
					</source>
                    <year>2012</year>;<volume>18</volume>(<issue>4</issue>):<fpage>167</fpage>&#x2013;<lpage>74</lpage>.
                    <pub-id pub-id-type="pmid">22398819</pub-id>
                    <pub-id pub-id-type="doi">10.1159/000335662</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref-9">
                <label>9</label>
                <mixed-citation publication-type="book">
                    <person-group person-group-type="author">
						
                        <name name-style="western">
                            <surname>Keith Conners</surname>
                            <given-names>C</given-names>
                        </name>
					</person-group>: PhD inventor;
                    <article-title>Conners 3rd Edition&#x2122; (Conners 3&#x2122;)</article-title>.<year>2013</year>.
                    <ext-link ext-link-type="uri" xlink:href="http://catalogue.jvrpsychometrics.co.za/conners-3rd-edition/">Reference Source</ext-link>
                </mixed-citation>
            </ref>
            <ref id="ref-10">
                <label>10</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">
						
                        <name name-style="western">
                            <surname>Dupaul</surname>
                            <given-names>GJ</given-names>
                        </name>
						
                        <name name-style="western">
                            <surname>Barkley</surname>
                            <given-names>RA</given-names>
                        </name>
					</person-group>:
                    <article-title>Situational Variability of Attention Problems: Psychometric Properties of the Revised Home and School Situations Questionnaire.</article-title>
                    <source>
						
                        <italic toggle="yes">J Clin Child Adolesc Psychol.</italic>
					</source>
                    <year>1992</year>;<volume>21</volume>(<issue>2</issue>):<fpage>178</fpage>&#x2013;<lpage>188</lpage>.
                    <pub-id pub-id-type="doi">10.1207/s15374424jccp2102_10</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref-11">
                <label>11</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">
						
                        <name name-style="western">
                            <surname>Dovis</surname>
                            <given-names>S</given-names>
                        </name>
						
                        <name name-style="western">
                            <surname>Van der Oord</surname>
                            <given-names>S</given-names>
                        </name>
						
                        <name name-style="western">
                            <surname>Wiers</surname>
                            <given-names>RW</given-names>
                        </name>
						
                        <etal/>
					</person-group>:
                    <article-title>Can motivation normalize working memory and task persistence in children with attention-deficit/hyperactivity disorder? The effects of money and computer-gaming.</article-title>
                    <source>
						
                        <italic toggle="yes">J Abnorm Child Psychol.</italic>
					</source>
                    <year>2012</year>;<volume>40</volume>(<issue>5</issue>):<fpage>669</fpage>&#x2013;<lpage>81</lpage>.
                    <pub-id pub-id-type="pmid">22187093</pub-id>
                    <pub-id pub-id-type="doi">10.1007/s10802-011-9601-8</pub-id>
                    <pub-id pub-id-type="pmcid">3375007</pub-id>
                </mixed-citation>
            </ref>
            <ref id="ref-12">
                <label>12</label>
                <mixed-citation publication-type="journal">
                    <person-group person-group-type="author">
						
                        <name name-style="western">
                            <surname>Wilkinson</surname>
                            <given-names>N</given-names>
                        </name>
						
                        <name name-style="western">
                            <surname>Ang</surname>
                            <given-names>RP</given-names>
                        </name>
						
                        <name name-style="western">
                            <surname>Goh</surname>
                            <given-names>DH</given-names>
                        </name>
					</person-group>:
                    <article-title>Online video game therapy for mental health concerns: a review.</article-title>
                    <source>
						
                        <italic toggle="yes">Int J Soc Psychiatry.</italic>
					</source>
                    <year>2008</year>;<volume>54</volume>(<issue>4</issue>):<fpage>370</fpage>&#x2013;<lpage>82</lpage>.
                    <pub-id pub-id-type="pmid">18720897</pub-id>
                    <pub-id pub-id-type="doi">10.1177/0020764008091659</pub-id>
                </mixed-citation>
            </ref>
        </ref-list>
    </back>
    <sub-article article-type="reviewer-report" id="report6739">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.6082.r6739</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Weinstein</surname>
                        <given-names>Aviv</given-names>
                    </name>
                    <xref ref-type="aff" rid="r6739a1">1</xref>
                    <role>Referee</role>
                </contrib>
                <aff id="r6739a1">
                    <label>1</label>Department of Behavioural Sciences, Ariel University, Ariel, Israel</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>25</day>
                <month>11</month>
                <year>2014</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2014 Weinstein A</copyright-statement>
                <copyright-year>2014</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport6739" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.5689.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>This is an interesting case report on the usefulness of cognitive computer training for a child who is diagnosed with ADHD and concurrent videogame addiction. The rationale for the study, methods and findings are fine but I would like to make some additional comments.</p>
            <p>First, the usefulness of treatment of ADHD and internet addiction by using methylphenidate was reported by 
                <ext-link ext-link-type="uri" xlink:href="http://www.ncbi.nlm.nih.gov/pubmed/19374970">Han D&#x00a0;
                    <italic>et al.,&#x00a0;</italic>2009</ext-link>, please add it to the introduction.</p>
            <p>Second, what evidence have you got that the child is not addicted to the educational game?</p>
            <p>Third, 4 hours of play of a videogame post-treatment is still a lot, this should be mentioned as a limitation.</p>
            <p>Fourth, &#x00a0;why were the Conners ratings after treatment for parents and teachers lower compared with pre-treatment?</p>
            <p>Fifth, the authors should be commended for the use of advanced computer games for treatment for ADHD. There are other tools for this purpose that are worthwhile mentioning such as ONTRAC (
                <ext-link ext-link-type="uri" xlink:href="http://www.ncbi.nlm.nih.gov/pubmed/24225015">Mishra 
                    <italic>et al.,</italic> 2013</ext-link>) and &#x00a0;the game reported by 
                <ext-link ext-link-type="uri" xlink:href="http://www.ncbi.nlm.nih.gov/pubmed/20649448">Prins PJ&#x00a0;
                    <italic>et al</italic>., 2011.</ext-link>
            </p>
            <p>Reviewer Expertise:</p>
            <p>NA</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
        <sub-article article-type="response" id="comment1117-6739">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Tajima-Pozo</surname>
                            <given-names>Kazuhiro</given-names>
                        </name>
                        <aff>Hospital Fundacion Alcorcon, Spain</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>10</day>
                    <month>12</month>
                    <year>2014</year>
                </pub-date>
            </front-stub>
            <body>
                <p>We have included the following new references and made the changes according to the reviewer comments. &#x00a0;</p>
                <p>Mishra J, Merzenich MM, Sagar R. Accessible online neuroplasticity-targeted training for children with ADHD. Child Adolesc Psychiatry Ment Health. 2013 Nov 14;7(1):38</p>
                <p>Prins PJ, Dovis S, Ponsioen A, ten Brink E, van der Oord S. Does computerized working memory training with game elements enhance motivation and training efficacy in children with ADHD? Cyberpsychol Behav Soc Netw. 2011 Mar;14(3):115-22.</p>
                <p>Han DH1, Lee YS, Na C, Ahn JY, Chung US, Daniels MA, Haws CA, Renshaw PF.</p>
                <p>The effect of methylphenidate on Internet video game play in children with attention-deficit/hyperactivity disorder.</p>
            </body>
        </sub-article>
        <sub-article article-type="response" id="comment1292-6739">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Tajima-Pozo</surname>
                            <given-names>Kazuhiro</given-names>
                        </name>
                        <aff>Hospital Fundacion Alcorcon, Spain</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>Dr. Kazuhiro Tajima-Pozo, participated in the development of &#x201c;ADHD Trainer&#x201d;, and other mental health applications at TKT Brain Solutions, which is a Spanish startup, integrated by medical doctors and engineers, whose aim is to develop mental health applications.</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>13</day>
                    <month>4</month>
                    <year>2015</year>
                </pub-date>
            </front-stub>
            <body>
                <p>We have included the following new references and made the changes according to the reviewer comments. &#x00a0;</p>
                <p>Mishra J, Merzenich MM, Sagar R. Accessible online neuroplasticity-targeted training for children with ADHD. Child Adolesc Psychiatry Ment Health. 2013 Nov 14;7(1):38</p>
                <p>Prins PJ, Dovis S, Ponsioen A, ten Brink E, van der Oord S. Does computerized working memory training with game elements enhance motivation and training efficacy in children with ADHD? Cyberpsychol Behav Soc Netw. 2011 Mar;14(3):115-22.</p>
                <p>Han DH1, Lee YS, Na C, Ahn JY, Chung US, Daniels MA, Haws CA, Renshaw PF.</p>
                <p>The effect of methylphenidate on Internet video game play in children with attention-deficit/hyperactivity disorder.</p>
            </body>
        </sub-article>
    </sub-article>
</article>
