<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2 20190208//EN" "http://jats.nlm.nih.gov/publishing/1.2/JATS-journalpublishing1.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="case-report" dtd-version="1.2" xml:lang="en">
    <front>
        <journal-meta>
            <journal-id journal-id-type="pmc">F1000Research</journal-id>
            <journal-title-group>
                <journal-title>F1000Research</journal-title>
            </journal-title-group>
            <issn pub-type="epub">2046-1402</issn>
            <publisher>
                <publisher-name>F1000 Research Limited</publisher-name>
                <publisher-loc>London, UK</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="doi">10.12688/f1000research.5689.4</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Case Report</subject>
                </subj-group>
                <subj-group>
                    <subject>Articles</subject>
                    <subj-group>
                        <subject>Child &amp; Adolescent Psychiatry</subject>
                    </subj-group>
                    <subj-group>
                        <subject>Developmental &amp; Pediatric Neurology</subject>
                    </subj-group>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Case Report: "ADHD Trainer": the mobile application that enhances cognitive skills in ADHD patients</article-title>
                <fn-group content-type="pub-status">
                    <fn>
                        <p>[version 4; peer review: 1 approved, 1 approved with reservations]</p>
                    </fn>
                </fn-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Ruiz-Manrique</surname>
                        <given-names>Gonzalo</given-names>
                    </name>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="yes">
                    <name>
                        <surname>Tajima-Pozo</surname>
                        <given-names>Kazuhiro</given-names>
                    </name>
                    <xref ref-type="corresp" rid="c1">a</xref>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Monta&#x00f1;es-Rada</surname>
                        <given-names>Francisco</given-names>
                    </name>
                    <xref ref-type="aff" rid="a1">1</xref>
                </contrib>
                <aff id="a1">
                    <label>1</label>Department of Psychiatry, Hospital Universitario Fundacion Alcorcon, Alcorcon, 28922, Spain</aff>
            </contrib-group>
            <author-notes>
                <corresp id="c1">
                    <label>a</label>
                    <email xlink:href="mailto:kazutajima@hotmail.com">kazutajima@hotmail.com</email>
                </corresp>
                <fn fn-type="con">
                    <p>Dr. Gonzalo Ruiz wrote the manuscript, supervised by Dr. Kazuhiro Tajima-Pozo and Dr. Francisco Monta&#x00f1;es-Rada. The patient and his family were invited to participate in this study. All authors agreed to the final content of the manuscript.</p>
                </fn>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>Dr. Kazuhiro Tajima-Pozo, participated in the development of &amp;ldquo;ADHD Trainer&amp;rdquo;, and other mental health applications at TKT Brain Solutions, which is a Spanish startup, integrated by medical doctors and engineers, whose aim is to develop mental health applications.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>10</day>
                <month>9</month>
                <year>2015</year>
            </pub-date>
            <pub-date pub-type="collection">
                <year>2014</year>
            </pub-date>
            <volume>3</volume>
            <elocation-id>283</elocation-id>
            <history>
                <date date-type="accepted">
                    <day>8</day>
                    <month>9</month>
                    <year>2015</year>
                </date>
            </history>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2015 Ruiz-Manrique G et al.</copyright-statement>
                <copyright-year>2015</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <self-uri content-type="pdf" xlink:href="https://f1000research.com/articles/3-283/pdf"/>
            <abstract>
                <p>We report the case of a 10 year old patient diagnosed with attention deficit hyperactivity disorder (ADHD) and comorbid video game addiction, who was treated with medication and a combination of a novel cognitive training method based on video games called TCT method. A great risk of developing video game or internet addiction has been reported in children, especially in children with ADHD. Despite this risk, we hypothesize that the good use of these new technologies might be useful in developing new methods of cognitive training. The cognitive areas in which a noticeable improvement was observed under the use of video games were visuospatial working memory and fine motor skills. TCT method is a cognitive training method that enhances cognitive skills such as attention, working memory, processing speed, calculation ability, reasoning, and visuomotor coordination. The purpose of reviewing this case is to highlight that regular cognitive computerized training in ADHD patients may improve some of their cognitive symptoms and might be helpful for treating video game addiction.</p>
            </abstract>
            <kwd-group kwd-group-type="author">
                <kwd>ADHD; mobile app; TCT method; working memory</kwd>
            </kwd-group>
            <funding-group>
                <funding-statement>The author(s) declared that no grants were involved in supporting this work.</funding-statement>
            </funding-group>
        </article-meta>
        <notes>
            <sec sec-type="version-changes">
                <label>Revised</label>
                <title>Amendments from Version 3</title>
                <p>A complete revision of the grammar by an english native speaker has been made. The "TCT method" has been described according to the reviewer comments, and also we have include a direct link to download the "ADHD Trainer app".</p>
            </sec>
        </notes>
    </front>
    <body>
        <sec sec-type="intro">
            <title>Introduction</title>
            <p>Attention deficit hyperactivity disorder (ADHD) is the most commonly diagnosed neurodevelopmental disorder in childhood, which affects 3% to 7% of the population worldwide
                <sup>
                    <xref ref-type="bibr" rid="ref-1">1</xref>
                </sup>. ADHD is characterized by distractibility, hyperactivity and impulsivity. The standard treatment for ADHD includes mainly medication, psychosocial and behavioral treatment, and cognitive training exercises.</p>
            <p>Cognitive training exercises are especially useful when cognitive impairment is observed and when a regular and personalized cognitive training is performed
                <sup>
                    <xref ref-type="bibr" rid="ref-2">2</xref>
                </sup>. Studies in participants with cognitive impairment have shown that regular and daily cognitive training can improve some of their cognitive symptoms
                <sup>
                    <xref ref-type="bibr" rid="ref-3">3</xref>,
                    <xref ref-type="bibr" rid="ref-4">4</xref>
                </sup>. In addition, recent studies have demonstrated that computerized working memory and executive function training programs lead to better results than ordinary cognitive training methods in children with ADHD
                <sup>
                    <xref ref-type="bibr" rid="ref-5">5</xref>&#x2013;
                    <xref ref-type="bibr" rid="ref-7">7</xref>
                </sup>.</p>
            <p>Children&#x2019;s use of electronic devices, Internet and video games, has noticeably increased in the last 10 years. Since the first case of Internet addiction was described in 1996 by Young
                <sup>
                    <xref ref-type="bibr" rid="ref-6">6</xref>
                </sup>, several other pathologies have been proposed including pathological gambling and dependence
                <sup>
                    <xref ref-type="bibr" rid="ref-7">7</xref>
                </sup>. Despite extensive research literature available, the prevalence and proper diagnostic criteria for pathological gaming are still debated among the scientific community
                <sup>
                    <xref ref-type="bibr" rid="ref-8">8</xref>
                </sup>. Gaming addiction represents part of the postulated construct of Internet addiction, and is the most widely studied specific form of Internet addiction to date
                <sup>
                    <xref ref-type="bibr" rid="ref-9">9</xref>
                </sup>. Prevalence estimates range from 2%
                <sup>
                    <xref ref-type="bibr" rid="ref-10">10</xref>
                </sup> to 15%
                <sup>
                    <xref ref-type="bibr" rid="ref-11">11</xref>
                </sup>, depending on the respective socio-cultural context, sample, and assessment criteria utilized. A great risk of developing video game or Internet addiction has been reported in children, and especially in those with ADHD
                <sup>
                    <xref ref-type="bibr" rid="ref-8">8</xref>
                </sup>. Despite this risk, we hypothesize that good use of these new technologies can be useful in developing new methods of cognitive training.</p>
        </sec>
        <sec sec-type="cases">
            <title>Case report</title>
            <p>This case study involves a 10 year old child born in Madrid (Spain) who received treatment in a childhood psychiatry unit for 2 years due to behavioral disorders and ADHD. No other previous medical history was reported. His mother, aged 35, received psychological treatment for anxiety 3 years ago. His father, aged 36, works as an engineer and presented no relevant medical history. The patient was their only son. The parents described a great addiction to video games in the last year, referring to 4 hours per day of video game playing. This affected his social interaction, causing a lack of imaginative play and poor academic scores. Teachers at the school reported deterioration in his academic performance over the past year. At that time, the child was treated with methylphenidate 40 mg per day. The patient&#x2019;s parents reported that the only significant change from the previous year was a major addiction to a war videogame.</p>
            <p>To reduce the exposure to video games, we used a novel technique, based on the Tajima Cognitive Method (TCT) called &#x201c;ADHD Trainer&#x201d;. It consists in a cognitive stimulation program with a mobile/tablet application designed specifically to treat ADHD. This app can be purchased at Google play and iTunes. 
                <ext-link ext-link-type="uri" xlink:href="https://itunes.apple.com/us/app/adhd-trainer/id687869470?l=us&amp;ls=1&amp;mt=8">https://itunes.apple.com/us/app/adhd-trainer/id687869470?l=us&amp;ls=1&amp;mt=8</ext-link>
            </p>
            <p>Behavioral and academic improvements were rated on the Conners Parent and Teacher Rating Scales (brief version) and Barkley School Situations Questionnaire.</p>
            <p>ADHD diagnosis was made according to DSM V criteria
                <sup>
                    <xref ref-type="bibr" rid="ref-9">9</xref>,
                    <xref ref-type="bibr" rid="ref-10">10</xref>
                </sup>. Attention was rated with CPT Conners Continuous Performance Test.</p>
            <p>Differential diagnosis between oppositional defiant disorder and ADHD disorder was considered, because most of the symptoms were observed at home; however angry or irritable mood was not observed.</p>
            <p>The patient was treated with a combination of methylphenidate and cognitive training method based in the TCT method. The patient received daily treatment with 40 mg of methylphenidate, and at least 10 minutes of daily cognitive training with the &#x201c;ADHD Trainer&#x201d; app.</p>
            <p>The TCT is a type of computer adaptive test (CAT), as it adapts to the individual&#x2019;s cognitive strengths and weaknesses, based on his own scores over time, as well as those of his peers. Users receive separate scores in different cognitive areas, including simple calculation, attention, perceptual reasoning, and visuomotor coordination (
                <xref ref-type="fig" rid="f1">Figure 1</xref>). The goal of the daily training is to reach a pre-set individualized score in different cognitive domains, in order to complete a week of successful training.</p>
            <fig fig-type="figure" id="f1" orientation="portrait" position="float">
                <label>Figure 1. </label>
                <caption>
                    <title>The cognitive areas treated with 
                        <italic toggle="yes">ADHD</italic> Trainer.</title>
                </caption>
                <graphic orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/7375/dbcde32c-8781-4e3b-bd46-780582eccef8_figure1.gif"/>
            </fig>
            <p>During the first month of cognitive training therapy, the patient was only allowed to play with specific games based on the TCT Method, using the &#x201c;ADHD Trainer&#x201d; (
                <xref ref-type="fig" rid="f2">Figure 2</xref>). The patient had to use the application every day at the same time, provided that in addition targets that were assigned in therapy (such as the progressive reduction in the number of hours to play other games and just being able to play with them once a week) were met. During the first month, he was allowed to play this game a maximum range of 4 hours per day. No addiction symptoms to this videogame was observed during the first month (tolerance, withdrawal or functional impairment). The average number of hours that the child played the video game was 1 hour a day. In the following months the objective was to play the game at least 10 minutes per day.</p>
            <fig fig-type="figure" id="f2" orientation="portrait" position="float">
                <label>Figure 2. </label>
                <caption>
                    <title>Capture of one of the games based in Trail Making Test.</title>
                </caption>
                <graphic orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/7375/dbcde32c-8781-4e3b-bd46-780582eccef8_figure2.gif"/>
            </fig>
            <p>In less than two months video game abuse was substantially reduced, limiting its use to weekends, and always for periods not exceeding 4 hours in total. Although 4 hours a day might seem an important amount of time for a single day, the global reduction of the time wasted in videogames and its limitation to the weekend means a significant improvement in this particular case.</p>
            <p>Behavioral and academic improvement was rated on the Conners Parent and Teacher Rating Scales and Barkley School Situations Questionnaire. The initial score of the Conners was 19 for the teachers and 20 for the parents, and after the cognitive training the scores were 15 for the teachers and 16 for the parents. The main severity score for the Barklay School Situations Questionnaire was 70 before starting the training, and 66 after the cognitive training.</p>
            <p>Both the school and the family reported a significant improvement in the patient after 6 months of TCT cognitive training, which included important improvements for both academic and behavioral outcomes.</p>
            <p>Examples of exercises that are practiced in one daily session are shown in 
                <xref ref-type="fig" rid="f2">Figure 2</xref>.</p>
        </sec>
        <sec sec-type="discussion">
            <title>Discussion</title>
            <p>Most of the studies reported so far the emphasize the potential addictive risk of new technologies and the influence they have on children&#x2019;s interpersonal development, by reducing the time children spend outside home and increasing the time they spend alone playing in front of a television or a computer screen
                <sup>
                    <xref ref-type="bibr" rid="ref-12">12</xref>
                </sup>. It is also known that new technologies may affect children's academic performance by reducing the number of hours that they dedicate to studying.</p>
            <p>There are few studies which focus on the positive aspects of new technologies and the opportunities that they offer for professionals and users to interact as well as the development of new therapeutic methods, that are capable of reaching the young.</p>
            <p>New technologies, in particular video games, can be used as therapeutic tools to train executive functions
                <sup>
                    <xref ref-type="bibr" rid="ref-6">6</xref>,
                    <xref ref-type="bibr" rid="ref-7">7</xref>
                </sup>. As they generate greater motivation in children and adolescents they will increase the frequency of performing cognitive tasks oriented to enhance executive functions, especially the working memory.</p>
            <p>There are key advantages for children practicing the TCT Method relative to traditional cognitive training therapies which include:</p>
            <p>1) Increased motivation in children for completing cognitive training therapy. This increase in motivation comes from: entertainment value (these games are designed to be similar to regular video games that children enjoy) and feedback on performances relative to own and peer scores (which improves children&#x2019;s sense of agency and self-efficacy, as demonstrated by documented research on motivation and learning)
                <sup>
                    <xref ref-type="bibr" rid="ref-11">11</xref>,
                    <xref ref-type="bibr" rid="ref-12">12</xref>
                </sup>.</p>
            <p>2) Ease of accessing the application. Children can play the games at any place or any time, day and night.</p>
        </sec>
        <sec sec-type="conclusions">
            <title>Conclusion</title>
            <p>ADHD patients are especially vulnerable to develop video gaming addition. ADHD patients often suffer from working memory and executive function dysfunctions, but we have observed that very few cognitive training techniques have been developed for ADHD patients in the last years. Poor completion rates of cognitive training in children with ADHD have been observed. We suggest that a daily cognitive computerized training in ADHD patients may improve some of their cognitive symptoms, and might be helpful for treating the video gaming addition.</p>
        </sec>
        <sec>
            <title>Consent</title>
            <p>Written informed consent to publish this report was obtained by the patient&#x2019;s parents.</p>
        </sec>
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                    <article-title>Conners 3rd Edition&#x2122; (Conners 3&#x2122;)</article-title>.<year>2013</year>.
                    <ext-link ext-link-type="uri" xlink:href="http://catalogue.jvrpsychometrics.co.za/conners-3rd-edition/">Reference Source</ext-link>
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                    <article-title>Can motivation normalize working memory and task persistence in children with attention-deficit/hyperactivity disorder? The effects of money and computer-gaming.</article-title>
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                    <year>2012</year>;<volume>40</volume>(<issue>5</issue>):<fpage>669</fpage>&#x2013;<lpage>81</lpage>.
                    <pub-id pub-id-type="pmid">22187093</pub-id>
                    <pub-id pub-id-type="doi">10.1007/s10802-011-9601-8</pub-id>
                    <pub-id pub-id-type="pmcid">3375007</pub-id>
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                    <article-title>Online video game therapy for mental health concerns: a review.</article-title>
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                    <pub-id pub-id-type="pmid">18720897</pub-id>
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    </back>
    <sub-article article-type="reviewer-report" id="report10258">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.7375.r10258</article-id>
            <title-group>
                <article-title>Reviewer response for version 4</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Black</surname>
                        <given-names>Kevin J.</given-names>
                    </name>
                    <xref ref-type="aff" rid="r10258a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-6921-9567</uri>
                </contrib>
                <aff id="r10258a1">
                    <label>1</label>Department of Psychiatry, Washington University in St. Louis, St Louis, MO, USA</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>30</day>
                <month>9</month>
                <year>2015</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2015 Black KJ</copyright-statement>
                <copyright-year>2015</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport10258" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.5689.4"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>The authors have satisfactorily addressed most of the concerns listed in my previous reviews, but did not address #3a or #5.</p>
            <p>Reviewer Expertise:</p>
            <p>NA</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report9143">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.7195.r9143</article-id>
            <title-group>
                <article-title>Reviewer response for version 3</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Black</surname>
                        <given-names>Kevin J.</given-names>
                    </name>
                    <xref ref-type="aff" rid="r9143a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-6921-9567</uri>
                </contrib>
                <aff id="r9143a1">
                    <label>1</label>Department of Psychiatry, Washington University in St. Louis, St Louis, MO, USA</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>26</day>
                <month>6</month>
                <year>2015</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2015 Black KJ</copyright-statement>
                <copyright-year>2015</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport9143" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.5689.3"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>The authors have addressed points #1 and 4 from my previous review, but the following issues remain.</p>
            <p>2. The paper still needs copy editing to reflect standard written English. The last 2 sentences of the Introduction provide an example.
                <list list-type="bullet">
                    <list-item>
                        <p>Comma placement: &#x00a0;Do the authors mean that video game play reduces Internet use, or do they mean that MPH is given for both ADHD and video game play?</p>
                    </list-item>
                    <list-item>
                        <p>"found reduce" -&gt; "found to reduce"</p>
                    </list-item>
                    <list-item>
                        <p>Here is one potential way to edit the last sentence&#x00a0;(insertions marked with bold; deletions marked with underline and subscript). &#x00a0;"Despite the risk of Internet addiction
                            <bold>,</bold> we hypothesize that 
                            <underline>
                                <sub>good use of </sub>
                            </underline>these new technologies&#x00a0;can be useful 
                            <sub>
                                <underline>to develop&#x00a0;</underline>
                            </sub>
                            <bold>as </bold>new methods of cognitive training 
                            <sub>
                                <underline>useful in </underline>
                            </sub>to treat ADHD an
                            <bold>d</bold> Internet addiction."&#x00a0;</p>
                    </list-item>
                </list>
            </p>
            <p>3a.&#x00a0;The exercises comprising "ADHD Trainer" are not described in any detail beyond listing the categories of mental functioning that each task is thought to reflect.&#x00a0;For instance, what task is used for "Attention"? Has this implementation of the task been validated elsewhere, or adapted with unpublished modifications from a published task? And so on for each of the categories listed in the Table.</p>
            <p>3b.&#x00a0;As with any method, the authors need to provide some kind of information about where the reader can obtain "ADHD Trainer".</p>
            <p>I have one additional comment that I forgot to add to the previous review.</p>
            <p>5. The authors should acknowledge, perhaps in Conclusion, that behavioral interventions other than ADHD Trainer itself may account in part or in whole&#x00a0;for the clinical improvement.&#x00a0;Other interventions the child received&#x00a0;include the following.&#x00a0;"The patient was only allowed to play with" ADHD Trainer. "The patient had to use the app every day at the same time." The patient had to meet "the other targets that were assigned in therapy" including a "progressive reduction in the number of hours to play other games" and limiting other game play to once a week.</p>
            <p>Reviewer Expertise:</p>
            <p>NA</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report8915">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.6850.r8915</article-id>
            <title-group>
                <article-title>Reviewer response for version 2</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Black</surname>
                        <given-names>Kevin J.</given-names>
                    </name>
                    <xref ref-type="aff" rid="r8915a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-6921-9567</uri>
                </contrib>
                <aff id="r8915a1">
                    <label>1</label>Department of Psychiatry, Washington University in St. Louis, St Louis, MO, USA</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>15</day>
                <month>6</month>
                <year>2015</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2015 Black KJ</copyright-statement>
                <copyright-year>2015</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport8915" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.5689.2"/>
            <custom-meta-group>
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                    <meta-value>approve-with-reservations</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>This is an interesting and encouraging report, but I have the following reservations.
                <list list-type="order">
                    <list-item>
                        <p>One case provides very limited evidence for efficacy and even less for safety. In this light, a couple of statements, including the following, are too enthusiastic and need to be toned down:</p>
                        <p>"regular cognitive computerized training in ADHD patients can improve some of their cognitive symptoms and can help treating video game addiction"</p>
                        <p>"We conclude that a daily cognitive computerized training in ADHD patients can improve some of their cognitive symptoms, and can help treating the video gaming addiction."</p>
                    </list-item>
                    <list-item>
                        <p>&#x200b;The manuscript is understandable, but needs copy editing by a native English speaker. For instance, the first sentence of the abstract has 2 errors, and the following phrase is really hard to parse: "the method of Tajima Cognitive Method (TCT) cognitive training called 'ADHD Trainer'."</p>
                    </list-item>
                    <list-item>
                        <p>The exercises comprising "ADHD Trainer" are not described in any detail beyond listing the categories of mental functioning that tasks were thought to reflect. If another publication or thesis describes it, a reference would suffice; otherwise a list of tasks would be a first step. Similarly, as with any method, the authors need to provide some kind of information about where the reader can obtain the TCT.&#x00a0;</p>
                    </list-item>
                    <list-item>
                        <p>The&#x00a0;Barkley School Situations Questionnaire was administered, but the scores are not reported.</p>
                    </list-item>
                </list>
            </p>
            <p>Reviewer Expertise:</p>
            <p>NA</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
        <sub-article article-type="response" id="comment1425-8915">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Tajima-Pozo</surname>
                            <given-names>Kazuhiro</given-names>
                        </name>
                        <aff>Hospital Fundacion Alcorcon, Spain</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>18</day>
                    <month>6</month>
                    <year>2015</year>
                </pub-date>
            </front-stub>
            <body>
                <p>According to the reviewer comments</p>
                <p>We have included a table showing the cognitive training areas that are trained everyday.</p>
                <p>We have made a overall review of the grammar.</p>
                <p>We have included the scores of the school situations questionnaire.</p>
                <p>Thanks for your review Mr. Black, and best regards.</p>
            </body>
        </sub-article>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report8583">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.6850.r8583</article-id>
            <title-group>
                <article-title>Reviewer response for version 2</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Weinstein</surname>
                        <given-names>Aviv</given-names>
                    </name>
                    <xref ref-type="aff" rid="r8583a1">1</xref>
                    <role>Referee</role>
                </contrib>
                <aff id="r8583a1">
                    <label>1</label>Department of Behavioural Sciences, Ariel University, Ariel, Israel</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>18</day>
                <month>5</month>
                <year>2015</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2015 Weinstein A</copyright-statement>
                <copyright-year>2015</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport8583" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.5689.2"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>approve</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>The authors have revised the manuscript to my full satisfaction</p>
            <p>Reviewer Expertise:</p>
            <p>NA</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.</p>
        </body>
        <sub-article article-type="response" id="comment1363-8583">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Tajima-Pozo</surname>
                            <given-names>Kazuhiro</given-names>
                        </name>
                        <aff>Hospital Fundacion Alcorcon, Spain</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>Dr. Kazuhiro Tajima-Pozo, have participated in the development of &#x201c;ADHD Trainer&#x201d; , and other brain training applications as consultant psychiatrist. </p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>18</day>
                    <month>5</month>
                    <year>2015</year>
                </pub-date>
            </front-stub>
            <body>
                <p>Thanks for your comments and your review. Best regards.</p>
            </body>
        </sub-article>
    </sub-article>
    <sub-article article-type="reviewer-report" id="report6739">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.6082.r6739</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Weinstein</surname>
                        <given-names>Aviv</given-names>
                    </name>
                    <xref ref-type="aff" rid="r6739a1">1</xref>
                    <role>Referee</role>
                </contrib>
                <aff id="r6739a1">
                    <label>1</label>Department of Behavioural Sciences, Ariel University, Ariel, Israel</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>25</day>
                <month>11</month>
                <year>2014</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2014 Weinstein A</copyright-statement>
                <copyright-year>2014</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport6739" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.5689.1"/>
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            </custom-meta-group>
        </front-stub>
        <body>
            <p>This is an interesting case report on the usefulness of cognitive computer training for a child who is diagnosed with ADHD and concurrent videogame addiction. The rationale for the study, methods and findings are fine but I would like to make some additional comments.</p>
            <p>First, the usefulness of treatment of ADHD and internet addiction by using methylphenidate was reported by 
                <ext-link ext-link-type="uri" xlink:href="http://www.ncbi.nlm.nih.gov/pubmed/19374970">Han D&#x00a0;
                    <italic>et al.,&#x00a0;</italic>2009</ext-link>, please add it to the introduction.</p>
            <p>Second, what evidence have you got that the child is not addicted to the educational game?</p>
            <p>Third, 4 hours of play of a videogame post-treatment is still a lot, this should be mentioned as a limitation.</p>
            <p>Fourth, &#x00a0;why were the Conners ratings after treatment for parents and teachers lower compared with pre-treatment?</p>
            <p>Fifth, the authors should be commended for the use of advanced computer games for treatment for ADHD. There are other tools for this purpose that are worthwhile mentioning such as ONTRAC (
                <ext-link ext-link-type="uri" xlink:href="http://www.ncbi.nlm.nih.gov/pubmed/24225015">Mishra 
                    <italic>et al.,</italic> 2013</ext-link>) and &#x00a0;the game reported by 
                <ext-link ext-link-type="uri" xlink:href="http://www.ncbi.nlm.nih.gov/pubmed/20649448">Prins PJ&#x00a0;
                    <italic>et al</italic>., 2011.</ext-link>
            </p>
            <p>Reviewer Expertise:</p>
            <p>NA</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.</p>
        </body>
        <sub-article article-type="response" id="comment1117-6739">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Tajima-Pozo</surname>
                            <given-names>Kazuhiro</given-names>
                        </name>
                        <aff>Hospital Fundacion Alcorcon, Spain</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>10</day>
                    <month>12</month>
                    <year>2014</year>
                </pub-date>
            </front-stub>
            <body>
                <p>We have included the following new references and made the changes according to the reviewer comments. &#x00a0;</p>
                <p>Mishra J, Merzenich MM, Sagar R. Accessible online neuroplasticity-targeted training for children with ADHD. Child Adolesc Psychiatry Ment Health. 2013 Nov 14;7(1):38</p>
                <p>Prins PJ, Dovis S, Ponsioen A, ten Brink E, van der Oord S. Does computerized working memory training with game elements enhance motivation and training efficacy in children with ADHD? Cyberpsychol Behav Soc Netw. 2011 Mar;14(3):115-22.</p>
                <p>Han DH1, Lee YS, Na C, Ahn JY, Chung US, Daniels MA, Haws CA, Renshaw PF.</p>
                <p>The effect of methylphenidate on Internet video game play in children with attention-deficit/hyperactivity disorder.</p>
            </body>
        </sub-article>
        <sub-article article-type="response" id="comment1292-6739">
            <front-stub>
                <contrib-group>
                    <contrib contrib-type="author">
                        <name>
                            <surname>Tajima-Pozo</surname>
                            <given-names>Kazuhiro</given-names>
                        </name>
                        <aff>Hospital Fundacion Alcorcon, Spain</aff>
                    </contrib>
                </contrib-group>
                <author-notes>
                    <fn fn-type="conflict">
                        <p>
                            <bold>Competing interests: </bold>Dr. Kazuhiro Tajima-Pozo, participated in the development of &#x201c;ADHD Trainer&#x201d;, and other mental health applications at TKT Brain Solutions, which is a Spanish startup, integrated by medical doctors and engineers, whose aim is to develop mental health applications.</p>
                    </fn>
                </author-notes>
                <pub-date pub-type="epub">
                    <day>13</day>
                    <month>4</month>
                    <year>2015</year>
                </pub-date>
            </front-stub>
            <body>
                <p>We have included the following new references and made the changes according to the reviewer comments. &#x00a0;</p>
                <p>Mishra J, Merzenich MM, Sagar R. Accessible online neuroplasticity-targeted training for children with ADHD. Child Adolesc Psychiatry Ment Health. 2013 Nov 14;7(1):38</p>
                <p>Prins PJ, Dovis S, Ponsioen A, ten Brink E, van der Oord S. Does computerized working memory training with game elements enhance motivation and training efficacy in children with ADHD? Cyberpsychol Behav Soc Netw. 2011 Mar;14(3):115-22.</p>
                <p>Han DH1, Lee YS, Na C, Ahn JY, Chung US, Daniels MA, Haws CA, Renshaw PF.</p>
                <p>The effect of methylphenidate on Internet video game play in children with attention-deficit/hyperactivity disorder.</p>
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