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    <front>
        <journal-meta>
            <journal-id journal-id-type="pmc">F1000Research</journal-id>
            <journal-title-group>
                <journal-title>F1000Research</journal-title>
            </journal-title-group>
            <issn pub-type="epub">2046-1402</issn>
            <publisher>
                <publisher-name>F1000 Research Limited</publisher-name>
                <publisher-loc>London, UK</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="doi">10.12688/f1000research.17894.1</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Research Article</subject>
                </subj-group>
                <subj-group>
                    <subject>Articles</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Consumer perspectives on reproductive health after using the Jakpros smart mobile health application: A cross-sectional, qualitative study</article-title>
                <fn-group content-type="pub-status">
                    <fn>
                        <p>[version 1; peer review: 1 not approved]</p>
                    </fn>
                </fn-group>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author" corresp="yes">
                    <name>
                        <surname>Wiweko</surname>
                        <given-names>Budi</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Conceptualization</role>
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                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Resources</role>
                    <role content-type="http://credit.niso.org/">Supervision</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <xref ref-type="corresp" rid="c1">a</xref>
                    <xref ref-type="aff" rid="a1">1</xref>
                    <xref ref-type="aff" rid="a2">2</xref>
                    <xref ref-type="aff" rid="a3">3</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Riyanti</surname>
                        <given-names>Aida</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Resources</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <xref ref-type="aff" rid="a2">2</xref>
                    <xref ref-type="aff" rid="a3">3</xref>
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                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Olivia</surname>
                        <given-names>Shanty</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
                    <role content-type="http://credit.niso.org/">Resources</role>
                    <role content-type="http://credit.niso.org/">Validation</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
                    <xref ref-type="aff" rid="a2">2</xref>
                    <xref ref-type="aff" rid="a3">3</xref>
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                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Priangga</surname>
                        <given-names>Muhammad</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
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                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Silvana</surname>
                        <given-names>Vita</given-names>
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                    <role content-type="http://credit.niso.org/">Data Curation</role>
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                    <role content-type="http://credit.niso.org/">Validation</role>
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                    <uri content-type="orcid">https://orcid.org/0000-0001-8741-3796</uri>
                    <xref ref-type="aff" rid="a2">2</xref>
                    <xref ref-type="aff" rid="a3">3</xref>
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                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Putro</surname>
                        <given-names>Aruan Lewis</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
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                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Wibawa</surname>
                        <given-names>Yohanes Satrya</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Methodology</role>
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                    <role content-type="http://credit.niso.org/">Software</role>
                    <xref ref-type="aff" rid="a2">2</xref>
                    <xref ref-type="aff" rid="a3">3</xref>
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                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Pertiwi</surname>
                        <given-names>Ilonna Putri</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Investigation</role>
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                    <role content-type="http://credit.niso.org/">Software</role>
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                    <role content-type="http://credit.niso.org/">Visualization</role>
                    <role content-type="http://credit.niso.org/">Writing &#x2013; Original Draft Preparation</role>
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                    <xref ref-type="aff" rid="a2">2</xref>
                    <xref ref-type="aff" rid="a3">3</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Zakirah</surname>
                        <given-names>Sarah Chairani</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Data Curation</role>
                    <role content-type="http://credit.niso.org/">Formal Analysis</role>
                    <role content-type="http://credit.niso.org/">Project Administration</role>
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                    <role content-type="http://credit.niso.org/">Writing &#x2013; Review &amp; Editing</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-2918-8970</uri>
                    <xref ref-type="aff" rid="a2">2</xref>
                    <xref ref-type="aff" rid="a3">3</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Harzif</surname>
                        <given-names>Achmad Kemal</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Resources</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-3552-1610</uri>
                    <xref ref-type="aff" rid="a1">1</xref>
                    <xref ref-type="aff" rid="a2">2</xref>
                    <xref ref-type="aff" rid="a3">3</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Pratama</surname>
                        <given-names>Gita</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Resources</role>
                    <uri content-type="orcid">https://orcid.org/0000-0001-5626-1283</uri>
                    <xref ref-type="aff" rid="a1">1</xref>
                    <xref ref-type="aff" rid="a2">2</xref>
                    <xref ref-type="aff" rid="a3">3</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Muharam</surname>
                        <given-names>R.</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Resources</role>
                    <uri content-type="orcid">https://orcid.org/0000-0001-5712-3931</uri>
                    <xref ref-type="aff" rid="a1">1</xref>
                    <xref ref-type="aff" rid="a2">2</xref>
                    <xref ref-type="aff" rid="a3">3</xref>
                </contrib>
                <contrib contrib-type="author" corresp="no">
                    <name>
                        <surname>Hestiantoro</surname>
                        <given-names>Andon</given-names>
                    </name>
                    <role content-type="http://credit.niso.org/">Resources</role>
                    <uri content-type="orcid">https://orcid.org/0000-0001-7424-679X</uri>
                    <xref ref-type="aff" rid="a1">1</xref>
                    <xref ref-type="aff" rid="a2">2</xref>
                    <xref ref-type="aff" rid="a3">3</xref>
                </contrib>
                <aff id="a1">
                    <label>1</label>Yasmin IVF Clinic, Dr. Cipto Mangunkusumo General Hospital, DKI Jakarta, 10430, Indonesia</aff>
                <aff id="a2">
                    <label>2</label>Human Reproductive, Infertility and Family Planning Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, DKI Jakarta, 10430, Indonesia</aff>
                <aff id="a3">
                    <label>3</label>Division of Reproductive Endocrinology and Infertility Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, DKI Jakarta, 10430, Indonesia</aff>
            </contrib-group>
            <author-notes>
                <corresp id="c1">
                    <label>a</label>
                    <email xlink:href="mailto:wiwekobudi@yahoo.co.id">wiwekobudi@yahoo.co.id</email>
                </corresp>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>AR, SO, VS and MP contributed towards the development of the Jakpros app. </p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>8</day>
                <month>4</month>
                <year>2019</year>
            </pub-date>
            <pub-date pub-type="collection">
                <year>2019</year>
            </pub-date>
            <volume>8</volume>
            <elocation-id>396</elocation-id>
            <history>
                <date date-type="accepted">
                    <day>27</day>
                    <month>3</month>
                    <year>2019</year>
                </date>
            </history>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2019 Wiweko B et al.</copyright-statement>
                <copyright-year>2019</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <self-uri content-type="pdf" xlink:href="https://f1000research.com/articles/8-396/pdf"/>
            <related-article elocation-id="10.12688/f1000research.20260.1" id="related-article-version-22260" journal-id="F1000Research" journal-id-type="pmc" related-article-type="companion" vol="8">
                <article-title>RETRACTED: Consumer perspectives on reproductive health after using the Jakpros smart mobile health application: A cross-sectional, qualitative study</article-title>
                <pub-id pub-id-type="doi">10.12688/f1000research.20260.1</pub-id>
            </related-article>
            <abstract>
                <p>

                    <bold>Background:</bold> Good reproductive health is important for individuals and also for the development of children. Knowledge plays an important role in women&#x2019;s reproduction health. Our study examined women&#x2019;s perspectives and knowledge of reproductive health after using the free Jakarta Reproduction Sehat (Jakpros) application (app) on a daily basis for two weeks.</p>
                <p>

                    <bold>Methods:</bold> Our study used a cross-sectional, qualitative design. The sample consisted of 12 participants from two sub-district general hospitals in Jakarta. Participants were chosen using purposive sampling and consisted of women of reproductive age who had completed previous questionnaires on their use of Jakpros. We used descriptive analytics and a qualitative method. Data were collected by direct observation in small focus group discussions.</p>
                <p>

                    <bold>Results:</bold> Participants said that after they used the Jakpros app, they were more aware of their reproductive health. Their knowledge increased after counselling combined with Jakpros usage. They also said that the features in the app made it easier to contact their doctor and to access their nearest hospital.</p>
                <p>

                    <bold>Conclusion:</bold> Jakpros is a convenient way to access reliable reproductive health information.</p>
            </abstract>
            <kwd-group kwd-group-type="author">
                <kwd>Jakarta Reproduksi Sehat</kwd>
                <kwd>Jakpros</kwd>
                <kwd>Mobile Application</kwd>
                <kwd>Reproductive Health</kwd>
                <kwd>Social Media</kwd>
            </kwd-group>
            <funding-group>
                <award-group id="fund-1" xlink:href="http://dx.doi.org/10.13039/100000200">
                    <funding-source>United States Agency for International Development</funding-source>
                    <award-id>GrantAID-497-A-1600004</award-id>
                    <award-id>SubGrantIIE00000078-UI-1.</award-id>
                </award-group>
                <funding-statement>This research publication is supported by the United States Agency for International Development (USAID) through the Sustainable Higher Education Research Alliance (SHERA) Program for University of Indonesia&#x2019;s Scientific Modeling, Application, Research, and Training for City-centered Innovation and Technology (SMART CITY) Project, Grant AID-497-A-1600004, Sub Grant IIE00000078-UI-1.</funding-statement>
                <funding-statement>
                    <italic>The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</italic>
                </funding-statement>
            </funding-group>
        </article-meta>
    </front>
    <body>
        <sec>
            <title>Expression of Concern</title>
            <p>Since publication, the F1000Research editorial office has been informed of concerns regarding suspected duplicate publication of this article. We have contacted the authors and all editorial activity has been suspended pending further investigation. Further action will be dependent on the outcome of these discussions.</p>
        </sec>
        <sec sec-type="intro">
            <title>Introduction</title>
            <p>Good reproductive health is important for individuals and also for the development of children. Reproductive health is, or should be, a serious concern for every woman. A nation&#x2019;s mortality and morbidity are dependent on the reproductive health of its citizens. Knowledge plays an important role in women&#x2019;s reproduction health. For example, it informs them on how and when to seek health services
                <sup>
                    <xref ref-type="bibr" rid="ref-1">1</xref>
                </sup>.</p>
            <p>Mobile health applications (apps) are rapidly proliferating and are widely used around the world to access health information
                <sup>
                    <xref ref-type="bibr" rid="ref-2">2</xref>
                </sup>. In 2018, more than 50% of people worldwide had at least one mobile health app on their device
                <sup>
                    <xref ref-type="bibr" rid="ref-3">3</xref>
                </sup>. There are more than 100,000 smartphone health apps available today. The main goal of internet-based health apps is ready accessibility
                <sup>
                    <xref ref-type="bibr" rid="ref-4">4</xref>
                </sup>. Mobile health apps have a number of benefits: they enable fast, easy searches of almost unlimited health information
                <sup>
                    <xref ref-type="bibr" rid="ref-2">2</xref>
                </sup>; they bring doctors and patients closer together; and they provide health information at any time
                <sup>
                    <xref ref-type="bibr" rid="ref-5">5</xref>
                </sup>.</p>
            <p>The increasing popularity of mobile health apps is due to a number of things. Firstly, people are more comfortable sharing their experiences, expressing emotions, and exchanging ideas on specific topics within a like-minded community. Secondly, people are curious and want more information about their health experiences
                <sup>
                    <xref ref-type="bibr" rid="ref-6">6</xref>
                </sup>. Mobile health apps have been successful in reducing health costs. Preventive action by internet disseminated information is much more efficient than manual methods such as brochures, leaflets or posters
                <sup>
                    <xref ref-type="bibr" rid="ref-7">7</xref>
                </sup>. Technology has the potential to alleviate time management issues involved in counselling, treatment waits, and registration
                <sup>
                    <xref ref-type="bibr" rid="ref-7">7</xref>
                </sup>.</p>
            <p>One limitation of mobile health apps is that, due to the lack of quality controls on the internet, they vary widely in quality and accuracy. Providing good-quality, evidence-based health information to patients is an important goal
                <sup>
                    <xref ref-type="bibr" rid="ref-6">6</xref>
                </sup>.</p>
            <p>Due to the increasing popularity of mobile health apps, the Jakarta Reproduction Sehat (Jakpros) smart mobile app was developed in 2018 (
                <xref ref-type="fig" rid="f1">Figure 1</xref>). This free app is specifically designed to provide women with a convenient way to improve reproductive health knowledge. Jakpros has a section that shows the nearest hospitals from patients to help them access medical care. Other features include an educational page with general information on reproductive health, which is divided into several sections (e.g. contraception, high-risk pregnancy, cancer). Furthermore, the Jakpros application has a question and answer service supported by obstetrics and gynecology doctors (
                <xref ref-type="fig" rid="f2">Figure 2B</xref>).</p>
            <fig fig-type="figure" id="f1" orientation="portrait" position="float">
                <label>Figure 1. </label>
                <caption>
                    <p>(
                        <bold>A</bold>) Jakpros log-in page; (
                        <bold>B</bold>) Jakpros news page.</p>
                </caption>
                <graphic orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/19570/93c8c6eb-80b1-45d7-a51b-83e20ed76943_figure1.gif"/>
            </fig>
            <fig fig-type="figure" id="f2" orientation="portrait" position="float">
                <label>Figure 2. </label>
                <caption>
                    <p>(
                        <bold>A</bold>) Educational Page Feature; (
                        <bold>B</bold>) Questions and Answers Section.</p>
                </caption>
                <graphic orientation="portrait" position="float" xlink:href="https://f1000research-files.f1000.com/manuscripts/19570/93c8c6eb-80b1-45d7-a51b-83e20ed76943_figure2.gif"/>
            </fig>
            <p>Currently, the Jakpros app is used in several subdistrict hospitals in Jakarta. The aim of the present study was to examine perspectives and knowledge of reproductive health issues in women who used Jakpros as part of their daily activity. Our results will help us improve the usage and quality of the Jakpros app for women in the community.</p>
        </sec>
        <sec sec-type="methods">
            <title>Methods</title>
            <p>This study follows on from our past quantitative research
                <sup>
                    <xref ref-type="bibr" rid="ref-8">8</xref>
                </sup>. In the previous study, participants used the Jakpros smart mobile app for 2 weeks. During this time, they read the educational page feature to enrich their knowledge (
                <xref ref-type="fig" rid="f2">Figure 2A</xref>). They could also consult their healthcare providers about their complaints or for health information (
                <xref ref-type="fig" rid="f2">Figure 2B</xref>). We saw an improvement in health knowledge using pre- and post-test questionnaires. In the current study, we explored participants&#x2019; opinions and detailed perspectives on reproductive health and the Jakpros application. We used a qualitative method to analyze the main topic.</p>
            <p>We explored the different perspectives and behaviors of participants in detail. We adopted phenomenology study as our basic paradigm. The goals of this paradigm are to evaluate participants&#x2019; experience to be as factual as possible. Furthermore, it describes the different perspectives of the participants
                <sup>
                    <xref ref-type="bibr" rid="ref-9">9</xref>
                </sup>.</p>
            <sec sec-type="subjects">
                <title>Participants and study setting</title>
                <p>Participants were recruited in May 2018. All participants had participated in a previous quantitative study of Jakpros. We recruited participants from two sub-district hospitals in Jakarta: Tanjung Priok Subdistrict Hospital and Tanah Abang Sub-district Hospital. We used purposive sampling of women with the following criteria:</p>
                <list list-type="bullet">
                    <list-item>
                        <p>They had previously participated in our quantitative research.</p>
                    </list-item>
                    <list-item>
                        <p>They had used the Jakpros application for 2 weeks.</p>
                    </list-item>
                    <list-item>
                        <p>They lived in Jakarta.</p>
                    </list-item>
                    <list-item>
                        <p>They provided written informed consent to participate.</p>
                    </list-item>
                </list>
                <p>Our study method was focus group discussion and direct observation during these discussions. The study consisted of two groups of six participants interviewed on different days. Discussions were held in the hospital hall. Our research team for the discussions consisted of two obstetrics and gynecology specialists (AR and SO) and one general practitioner (IPP).</p>
            </sec>
            <sec>
                <title>Use of Jakpros</title>
                <p>The participants were instructed to use the Jakpros app for two weeks on a daily basis. Information on nutrition during pregnancy, contraception and family planning, cervical cancer, and high-risk pregnancy were given to participants in the Jakpros app, such as.</p>
            </sec>
            <sec>
                <title>Data collection</title>
                <p>The list of questions was prepared by our obstetrics and gynecology specialist from Universitas Indonesia. Each participant was interviewed within 10 minutes using a list of questions.</p>
                <p>The reproductive section of the discussion used the same questions as our previous questionnaire
                    <sup>
                        <xref ref-type="bibr" rid="ref-8">8</xref>
                    </sup> by modifying the quantitative questions into qualitative questions. For this study, we were able to record participants&#x2019; answers and their perspectives too. Participants were asked about their reproductive knowledge in areas such as cancer, cervical cancer, pregnancy care, contraception, and high-risk pregnancy. We asked these questions to measure participants&#x2019; knowledge after using Jakpros for 2 weeks. Next, we focused on participants&#x2019; use of the Jakpros application. They shared their personal experiences of using it in their day-to-day lives. Participants were asked about obstacles and benefits of using the application.</p>
                <p>In the discussion, we asked questions and participants took turns to answer them. We also facilitated the discussion. We emphasized that there were no wrong or right answers, we did not offer opinions and took a neutral stance to answers. We tried to make the discussion as relaxed as possible so participants would enjoy it. Each discussion lasted one hour, we audio-recorded all of the discussion and documented it with photos. For data analysis, we transcribed the data from audio-recorder into narrative document.</p>
            </sec>
        </sec>
        <sec sec-type="results">
            <title>Results</title>
            <p>The discussion forum was conducted with 12 participants from two sub-district hospitals in Jakarta. Most of them were homemakers, 24&#x2013;38 years old with high school diplomas as their highest educational qualification. All had participated in our previous quantitative study, which included a post-test questionnaire. This current study was a qualitative study, with results obtained using focused discussion.</p>
            <sec>
                <title>Cervical cancer in reproductive health</title>
                <p>Our first question was about cancer in reproductive health, and the discussion of perspectives went into considerable depth. Early identification and treatment of cancer improves outcomes, so awareness can be life-saving. Answers were promising; participants knew about several types of cancer in women and their initial symptoms, and the etiology of cervical cancer and that it is preventable by HPV vaccination. Some of them knew about the type of examination for detection of malignancy, and treatments such as radiotherapy or hysterectomy in cervical cancer. They understood about the importance of hygiene in cervical cancer prevention, and that more sexual partners increases the risk of cervical cancer.</p>
                <list list-type="bullet">
                    <list-item>
                        <label/>
                        <p>
                            <italic toggle="yes">&#x201c;Cervical cancer is cancer in the neck of uterus. I know other types of cancer in women such as ovarian cancer. For the signs, bleeding is a sign for cervical cancer and bump in breast for breast cancer. I heard food can be an etiology for cervical cancer. A blood test is for detecting cervical cancer. I heard too for cervical cancer treatment, the doctor will do cryotherapy, but I do not know what it is and doctor will do surgery too. To prevent it, we have to maintain good genital hygiene such as changing pads regularly during periods and getting HPV vaccination. I think people who are sexually active have to have further examinations for early detection and if the result is positive, the treatment will be done earlier.&#x201d;</italic>
</p>
                        <p>
                            <italic toggle="yes">&#x201c;The breast cancer shows as a bump in the breast and changes in the skin surface like an orange skin. I&#x2019;ve heard about USG for detecting ovarian cancer and, if positive, the doctor will do radiotherapy.&#x201d;</italic>
                        </p>
                        <p>
                            <italic toggle="yes">&#x201c;I think bloody pee is a sign of cervical cancer, but I am not sure. It&#x2019;s caused by HPV virus. Causes can be genetic and a large number of sexual partners. Detection is by pap smear examination. One of type of treatment is chemotherapy. My friend did it before, she had cervical cancer and now she has passed away. Preventable measures are good hygiene and being faithful to your sexual partner. I heard about HPV vaccine, you will do it three times and you can get hepatitis B vaccine too. If people are sexually active, they have to do routine pap smears or IVA tests at least once a year.&#x201d;</italic>
                        </p>
                        <p>
                            <italic toggle="yes">&#x201c;The important things for prevention are don&#x2019;t ever change your sexual partner, be faithful and keep good hygiene. Get your pap smear test after marriage.&#x201d;</italic>
                        </p>
                        <p>
                            <italic toggle="yes">&#x201c;Bleeding is an early sign of uterus neck cancer. I do not know the difference between cervical cancer or uterus neck cancer. But I know IVA is an early test to detect malignancy. If you are sexually active, you should get the test so you can be treated early if you have it.&#x201d;</italic>
                        </p>
                    </list-item>
                </list>
            </sec>
            <sec>
                <title>Anemia and nutrition in pregnancy</title>
                <p>The second question was about anemia and nutrition in pregnancy. Anemia and nutrition are related, and this information is covered in the Jakpros education section. Most participants did not know the initial symptoms of anemia, or the main nutrition components recommended during pregnancy, but most participants knew the main symptoms of anemia. They knew about tests and treatment for anemia, but there was less understanding of the importance of iron in food. Surprisingly, just one participant noted that postpartum hemorrhage can have anemia as a complication. Their answers about nutrition showed only basic knowledge.</p>
                <list list-type="bullet">
                    <list-item>
                        <label/>
                        <p>

                            <italic toggle="yes">&#x201c;Sign of anemia are dizziness and weakness. Anemia is decreased of red blood cells which can be measured through blood test. So the doctor will give blood booster supplement. If you get anemia during your pregnancy, you will need a blood transfusion after birth. I know components of nutrition are carbohydrate, calcium, iron, fat, vegetable and vitamins. Those are so important in pregnancy. Calcium for fetal bone. Protein for fetal brain, carbohydrate for fetal weight and iron for mother blood. I am not sure, but I think you have to take folic acid, iron and calcium supplement once in daily during trimester 2 and 3.&#x201d;</italic>
</p>
                        <p>
                            <italic toggle="yes">&#x201c;Anemia is decreased iron in your body. I eat meat regularly to prevent it. Bleeding after birth can cause anemia which is a serious side effect. I know folic acid important for your baby&#x2019;s brain.&#x201d;</italic>
                        </p>
                        <p>
                            <italic toggle="yes">&#x201c;If your blood is decreased you will be dizzy. The reason you feel it is because your nutrition is low. Good nutrition is important.&#x201d;</italic>
                        </p>
                        <p>
                            <italic toggle="yes">&#x201c;Anemia can be prevented by eating food that contains iron. A baby&#x2019;s weight will be low because of it.&#x201d;</italic>
                        </p>
                        <p>
                            <italic toggle="yes">Anemia is lack of blood, we need vitamins.&#x201d;</italic>
                        </p>
                        <p>
                            <italic toggle="yes">&#x201c;During anemia, the sign is nausea.&#x201d;</italic>
                        </p>
                    </list-item>
                </list>
            </sec>
            <sec>
                <title>Contraception and family planning</title>
                <p>We continued the discussion by asking about contraception and family planning. Knowledge on contraception and family planning are crucial for all couples. Although two or three participants declined to answer or participate in discussion of previous questions, most answered this question. This appeared to reflect their knowledge of or interest in these topics. They answered the question and shared their personal experience. Most participants were sexually active and knew about contraception. They knew what its main goals were, and how various contraception types functioned, and what their side effects were. They were also confident in their ability to choose contraception. In most cases, their husbands and doctors were involved in their choice of contraception. Participants felt that they knew their bodies better than other people and considered what was best for their bodies when they chose contraception.</p>
                <list list-type="bullet">
                    <list-item>
                        <label/>
                        <p>

                            <italic toggle="yes">&#x201c;Type of contraception are condom, pill, IUD and injection. I have used the pill and it made me fat. Pills and injections will make you gain weight. For injections, you must have regular injections monthly or every three months. I was lazy and I choose an IUD. It can be used for five years. I had a USG check before choose the IUD and I involved my husband in my choice. Now, I use an IUD for contraception&#x201d;</italic>
</p>
                        <p>
                            <italic toggle="yes">&#x201c;The aim of contraception is to space pregnancies. I used not to use contraception. I was pregnant 1.5 years ago and I am two months pregnant right now.&#x201d;</italic>
                        </p>
                        <p>
                            <italic toggle="yes">&#x201c;The only contraception for preventing STD is condoms. I know that side effects of the pill and injections is bleeding. I talked to my husband before I choose contraception. Our convenience is important.&#x201d;</italic>
                        </p>
                        <p>
                            <italic toggle="yes">&#x201c;I used contraception for spacing my pregnancies. Types of contraception are the calendar method (the traditional method), pills, condoms, and surgery. Condoms can prevent STD, the pill causes bleeding. IUDs will make you bleed too, but not gain weight. If you are careless, you shouldn&#x2019;t use the pill or injection. I saw my doctor before I chose contraception. Now I use natural methods such as the calendar method and coitus interruptus. My husband and I can work together.&#x201d;</italic>
                        </p>
                        <p>
                            <italic toggle="yes">&#x201c;I take a pill a day. I always remember it. It depends on your body, just you know it well.&#x201d;</italic>
                        </p>
                        <p>
                            <italic toggle="yes">&#x201c;IUD can be used for five years. It works for me.&#x201d;</italic>
                        </p>
                    </list-item>
                </list>
            </sec>
            <sec>
                <title>High-risk pregnancy</title>
                <p>This was the last question about reproductive health. In this section, we asked about the signs of high-risk pregnancy. We wanted to see how aware participants were of its symptoms. They seemed to know early signs, but not much beyond that. They knew it affected both the fetus and themselves. For this question, participants did not describe their experiences. They offered fewer comments than for the previous question. We assumed that they had never been in that situation, or that they did not know much about this topic. But we considered it positive that they were aware of early signs of risk.</p>
                <list list-type="bullet">
                    <list-item>
                        <label/>
                        <p>

                            <italic toggle="yes">&#x201c;High-risk pregnancy is if the mother has a history of asthma, untreatable nausea and bleeding. We have to take vitamins regularly and control every month to prevent it.&#x201d;</italic>
</p>
                        <p>
                            <italic toggle="yes">&#x201c;If mother has diabetes, the baby will be overweight, and it is not healthy.&#x201d;</italic>
                        </p>
                        <p>
                            <italic toggle="yes">&#x201c;Hypertension in pregnancy causes side effects such as seizure and the death of fetus. Headache is an early sign. You can check your blood pressure.&#x201d;</italic>
                        </p>
                        <p>
                            <italic toggle="yes">&#x201c;An example of high risk is a mother with asthma. People have to have bed rest in pregnancy and not get too tired.&#x201d;</italic>
                        </p>
                        <p>
                            <italic toggle="yes">&#x201c;Vaginal discharge is serious sign and might lead to preterm delivery.&#x201d;</italic>
                        </p>
                        <p>
                            <italic toggle="yes">&#x201c;Diabetes in pregnancy is high risk. Be aware.&#x201d;</italic>
                        </p>
                    </list-item>
                </list>
            </sec>
            <sec>
                <title>Implementation of Jakpros for daily use</title>
                <p>Our last question asked about participants&#x2019; experiences of the Jakpros application &#x2013; what were benefits or obstacles for daily use. Participants shared opinions and stories. They were positive about the Jakpros application and its benefits for them, such as increased knowledge.</p>
                <list list-type="bullet">
                    <list-item>
                        <label/>
                        <p>

                            <italic toggle="yes">&#x201c;I used it to get knowledge about reproductive health. My purpose was to get updated news. So I routinely read the educational page. It would be better if they posted it every day or weekly, so I could be better updated.&#x201d;</italic>
</p>
                        <p>
                            <italic toggle="yes">&#x201c;I checked my doctor&#x2019;s schedule through Jakpros. It made easier to access information, and I didn&#x2019;t have to call the hospital to ask. I can check my pregnancy estimate by inputting the dates of my last period. Unfortunately, it is not connected to direct registration and is not available in all Jakarta hospitals.&#x201d;</italic>
                        </p>
                        <p>
                            <italic toggle="yes">&#x201c;Jakpros has increased my knowledge. I totally trust it because I get it from trusted sources. The question and answer section helped me a lot. Sometimes I feel too shy or lazy to go to a doctor just to ask something. Now I can access information anywhere.&#x201d;</italic>
                        </p>
                        <p>

                            <italic toggle="yes">&#x201c;I can ask a doctor questions without hesitation and shame. I wish the doctors could be online 24 hours a day, and give faster responses.&#x201d;</italic>
</p>
                    </list-item>
                </list>
            </sec>
        </sec>
        <sec sec-type="discussion">
            <title>Discussion</title>
            <p>In this study, we explored participants&#x2019; knowledge and perspectives of reproductive health and experiences of the Jakpros application after using it on a daily basis for two weeks. Firstly, they could recognize the early signs of cancer or something wrong with their bodies (e.g. bleeding, bumps in breast). Furthermore, for cancer, they knew about basic diagnostic examinations and treatment. Our results were the qualitative study from our previous quantitative study, which found that women are likely to inform themselves of signs and risk factors for cancer in reproductive systems. They were alert to its signs and risk factors
                <sup>
                    <xref ref-type="bibr" rid="ref-10">10</xref>
                </sup>. According to another previous study, patients search the internet for further information about their symptoms and rely on this information to make decisions about their health
                <sup>
                    <xref ref-type="bibr" rid="ref-11">11</xref>
                </sup>. In our study, we found that participants understood about cervical cancer prevention. They told us that to prevent it people have to maintain good genital hygiene, not change sexual partners, and have regular HPV vaccinations. They agreed that sexually active or married people should have routine examinations routinely too for prevention and early detection. In a previous study, social media has been found to be an effective platform for increasing knowledge and awareness of cancer
                <sup>
                    <xref ref-type="bibr" rid="ref-12">12</xref>
                </sup>.</p>
            <p>When we asked about contraception, we found that participants were more confident and willing to speak. They could explain what contraception was used for, and also knew about the benefits and side effects of various types of contraception. They involved their husbands and doctors in making their decisions about contraception. They perceived contraception as a way of controlling pregnancy. They told us that family planning was important and required the cooperation of their husbands and consideration of their own bodies and needs. They depended on their social networks for information in making their decisions about contraception. The participants said they were more comfortable obtaining information from their doctors after they read information in Jakpros application. However, they were also interested in further discussion on social media.</p>
            <p>For the discussion on pregnancy, we asked participants about anemia, nutrition, and high-risk pregnancy. They knew the definition of anemia, and its early signs, examination, treatment and prevention. They agreed that anemia in pregnancy is a serious condition. Also, they said that nutrition was important in pregnancy, and they could name the nutritional components how they function in pregnancy. They were aware of early signs of high-risk pregnancy. They considered that to prevent pregnancy becoming high risk, women should have regular antenatal care visits and keep a healthy lifestyle during pregnancy. In our past study we found that pregnant women tend to use mobile health applications &#x2013; for example, to network within communities of people who have the same condition as them. Pregnancy can be stressful, and women can get reassurance by sharing their experiences in online discussion groups. Women also appreciate the convenience of being able to access advice and information any time
                <sup>
                    <xref ref-type="bibr" rid="ref-13">13</xref>
                </sup>.</p>
            <p>The increasing use of digital devices impacts community expectations for accessing health information. All participants agreed that Jakpros provided a service that helped them access information. Our previous study showed that people like to get information as fast as possible and from wherever they are
                <sup>
                    <xref ref-type="bibr" rid="ref-8">8</xref>
                </sup>. Most of our respondents felt that going to the doctor required too much effort to go to doctor
                <sup>
                    <xref ref-type="bibr" rid="ref-13">13</xref>
                </sup>.</p>
            <p>Previous studies have described how poor-quality information online can lead to health consumers making ill informed decisions
                <sup>
                    <xref ref-type="bibr" rid="ref-6">6</xref>
                </sup> Our study showed that patients did not hesitate to get information from Jakpros, and they felt this platform delivered reliable medical information. In particular, they appreciated the free advice from doctors about their reproductive problems.</p>
            <p>In response to participant comments, there are a number of things we could do to improve the quality of the app. Firstly, to update the educational page more regularly. Secondly, to improve doctor responses to questions, ideally within 24 hours. Lastly, we hope to extend the information on doctor availability from a few sub-district hospitals to all hospitals in Jakarta.</p>
            <p>In our previous quantitative study, we found that user knowledge increased after two weeks&#x2019; use. This current study demonstrated users&#x2019; perspectives on reproductive health after using the app. In addition to basic knowledge of reproductive health, their level of awareness had increased, as was observed in the previous quantitative study
                <sup>
                    <xref ref-type="bibr" rid="ref-8">8</xref>
                </sup>. The knowledge and awareness provided by Jakpros can help inform women&#x2019;s important decisions on their reproductive health.</p>
            <p>Limitations of this study include the lack of perspective study of the consumers as the references of our qualitative and previous quantitative study of Jakpros application, and the short time allocated to the previous quantitative study.</p>
        </sec>
        <sec sec-type="conclusions">
            <title>Conclusions</title>
            <p>Respondents felt that Jakpros was a helpful application for daily use. Future development of this application is still needed to improve its features. Our aim for Jakpros is that it will one day be a platform for women to access reliable health information that they can apply in their lives.</p>
        </sec>
        <sec>
            <title>Ethical approval</title>
            <p>This study was approved by the Ethics Committee of the Faculty of Medicine Universitas Indonesia, Jakarta (Committee reference number: 1326/UN2.F1/ETIK/2018).</p>
        </sec>
        <sec>
            <title>Data availability</title>
            <sec>
                <title>Underlying data</title>
                <p>Harvard Dataverse: Replication Data for: Supplementary Files for Jakpros_F1000. 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.7910/DVN/KMF8BG">https://doi.org/10.7910/DVN/KMF8BG</ext-link>
                    <sup>
                        <xref ref-type="bibr" rid="ref-14">14</xref>
                    </sup>
                </p>
                <p>The project contains the following underlying data files:</p>
                <list list-type="bullet">
                    <list-item>
                        <label>- </label>
                        <p>Transkrip Wawancara Pasien NEW &#x2013; blind name: Transcripts from the focus group discussions</p>
                    </list-item>
                </list>
            </sec>
            <sec>
                <title>Extended data</title>
                <p>Harvard Dataverse: Replication Data for: Supplementary Files for Jakpros_F1000. 
                    <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.7910/DVN/KMF8BG">https://doi.org/10.7910/DVN/KMF8BG</ext-link>
                    <sup>
                        <xref ref-type="bibr" rid="ref-14">14</xref>
                    </sup>
                </p>
                <p>The project contains the following extended data files:</p>
                <list list-type="bullet">
                    <list-item>
                        <label>- </label>
                        <p>Wawancara Kualitatif Pasien 1: Interview guidelines</p>
                    </list-item>
                </list>
                <p>Data are available under the terms of the 
                    <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">Creative Commons Zero "No rights reserved" data waiver</ext-link> (CC0 1.0 Public domain dedication).</p>
            </sec>
        </sec>
    </body>
    <back>
        <ack>
            <title>Acknowledgements</title>
            <p>The authors thank Ann Seward, ELS, of AuthorAID, for English-language assistance with an early draft of the manuscript.</p>
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    <sub-article article-type="reviewer-report" id="report52067">
        <front-stub>
            <article-id pub-id-type="doi">10.5256/f1000research.19570.r52067</article-id>
            <title-group>
                <article-title>Reviewer response for version 1</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="author">
                    <name>
                        <surname>Almstrup</surname>
                        <given-names>Kristian</given-names>
                    </name>
                    <xref ref-type="aff" rid="r52067a1">1</xref>
                    <role>Referee</role>
                    <uri content-type="orcid">https://orcid.org/0000-0002-1832-0307</uri>
                </contrib>
                <aff id="r52067a1">
                    <label>1</label>Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark</aff>
            </contrib-group>
            <author-notes>
                <fn fn-type="conflict">
                    <p>
                        <bold>Competing interests: </bold>No competing interests were disclosed.</p>
                </fn>
            </author-notes>
            <pub-date pub-type="epub">
                <day>6</day>
                <month>8</month>
                <year>2019</year>
            </pub-date>
            <permissions>
                <copyright-statement>Copyright: &#x00a9; 2019 Almstrup K</copyright-statement>
                <copyright-year>2019</copyright-year>
                <license xlink:href="https://creativecommons.org/licenses/by/4.0/">
                    <license-p>This is an open access peer review report distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
                </license>
            </permissions>
            <related-article ext-link-type="doi" id="relatedArticleReport52067" related-article-type="peer-reviewed-article" xlink:href="10.12688/f1000research.17894.1"/>
            <custom-meta-group>
                <custom-meta>
                    <meta-name>recommendation</meta-name>
                    <meta-value>reject</meta-value>
                </custom-meta>
            </custom-meta-group>
        </front-stub>
        <body>
            <p>The manuscript by Wiweko 
                <italic>et al.</italic> submitted to 
                <italic>F1000Research</italic> investigates how the users of the Jakpros app can help users to get a better knowledge of their reproductive health.</p>
            <p> Although the manuscript appears well-written and is submitted to a scientific research journal as a research article, this study does not appear to be a well-conducted scientific study.&#x00a0;</p>
            <p> The data and collection of data appear highly biased for the following reasons: Four of the authors have been involved in the development of the app, the study population is small and appear highly selective, there is no baseline interview (only post-use interviews), the questionnaires have not been validated, and the results are based on group interviews where participants easily can influence the opinion of each other.</p>
            <p> Furthermore, the authors have published on the Jakpros app before and in the Wiweko 
                <italic>et al.</italic> (2019
                <sup>
                    <xref ref-type="bibr" rid="rep-ref-52067-1">1</xref>
                </sup>) paper, which is 
                <bold>not</bold> cited in this manuscript - the title, list of authors, study population, cited references, as well as several whole paragraphs of the text, appear to be the same.</p>
            <p> Taken together, this manuscript appears to be a copy of an earlier paper and the study does not adhere to good scientific practise.</p>
            <p>Is the work clearly and accurately presented and does it cite the current literature?</p>
            <p>Partly</p>
            <p>If applicable, is the statistical analysis and its interpretation appropriate?</p>
            <p>Not applicable</p>
            <p>Are all the source data underlying the results available to ensure full reproducibility?</p>
            <p>Partly</p>
            <p>Is the study design appropriate and is the work technically sound?</p>
            <p>No</p>
            <p>Are the conclusions drawn adequately supported by the results?</p>
            <p>No</p>
            <p>Are sufficient details of methods and analysis provided to allow replication by others?</p>
            <p>Partly</p>
            <p>Reviewer Expertise:</p>
            <p>Reproduction, endocrinology, genomics</p>
            <p>I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above.</p>
        </body>
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