Prevalence of pre-operative anxiety and associated factors among a group of women undergoing gynaecological surgeries at a single unit in a tertiary care hospital in Sri Lanka

Madura Jayawardane; Wedisha Gankanda; Malsha Gunathilake

doi:10.12688/f1000research.26964.1

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Research Article

Prevalence of pre-operative anxiety and associated factors among a group of women undergoing gynaecological surgeries at a single unit in a tertiary care hospital in Sri Lanka

[version 1; peer review: 1 approved, 2 approved with reservations]

Madura Jayawardane ¹, Wedisha Gankanda², Malsha Gunathilake³

PUBLISHED 05 Feb 2021

Author details Author details

¹ Senior Lecturer, Department of Gynaecology and Obstetrics, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka
² Acting Consultant in Gynaecology and Obstetrics, Colombo South Teaching Hospital, Kalubowila, Sri Lanka
³ Senior Registrar in Psychiatry, National Institute of Mental Health, Angoda, Sri Lanka

Madura Jayawardane
Roles: Conceptualization, Investigation, Methodology, Project Administration, Supervision, Writing – Original Draft Preparation, Writing – Review & Editing

Wedisha Gankanda
Roles: Data Curation, Formal Analysis, Investigation, Resources, Software, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing

Malsha Gunathilake
Roles: Data Curation, Formal Analysis, Investigation, Resources, Software, Validation, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing

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Abstract

Background: Surgery-related anxiety is universal, leading to complications. The objective of this study was to assess the prevalence of pre-operative anxiety levels among a group of patients.
Methods: A descriptive cross-sectional study of 64 women was conducted in a tertiary care hospital, Sri Lanka. Patients who underwent emergency surgeries, those with mental illnesses or those aged <18 years were excluded. Pre-operative assessment was done one day prior to the surgery using a self-administered Sinhala validated Amsterdam-Preoperative-Anxiety-and-Information-Scale (APAIS), Hospital Anxiety and Depression Scale (HADS) and Visual-Analogue-Scale (VAS). The APAIS consists of six questions which assess three anxiety components: anesthesia-related-anxiety (Sum A), surgery-related-anxiety (Sum S) and information-desire-component (Sum IDC). The combined score (Sum C) is given by the total of Sum A and Sum S. A Sum C of ≥11 indicates significant anxiety.
Results: The mean age of participants was 38.03 years (SD=13.53 years). The mean total score of APAIS was 10.36 (4.06), of HADS was 5.734 (4.487) and of VAS was 3.156 (2.773). All scores were higher in participants <50 years. There were negative correlations between age and anxiety levels in VAS and APAIS scales; the Sum IDC in APAIS (r=-0.416, p=0.001) and VAS scores (r=-246, p=0.050) showed significant negative correlations. Excepting Sum IDC all APAIS, HADS and VAS scores were higher among the group without insurance; despite free healthcare. However only Sum S (t=-3.716, p=0.000) and Sum C (t=-2.281, p=0.026) in APAIS, HADS (t=-3.412, p=0.001) and VAS (t=-2.135, p=0.037) had statistically higher values. Anxiety scores were higher in the group that underwent minor surgeries but where not significantly related to education level, marital status, income, employment or living status.
Conclusions: Pre-operative anxiety is common. Age <50 years, lacking insurance cover and undergoing minor surgeries are associated with increased pre-operative anxiety levels. Screening and appropriate interventions would be beneficial.

Keywords

Pre-operative anxiety, Surgery related anxiety, Anxiety

Corresponding author: Madura Jayawardane

Competing interests: No competing interests were disclosed.

Grant information: The author(s) declared that no grants were involved in supporting this work.

Copyright: © 2021 Jayawardane M et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

How to cite: Jayawardane M, Gankanda W and Gunathilake M. Prevalence of pre-operative anxiety and associated factors among a group of women undergoing gynaecological surgeries at a single unit in a tertiary care hospital in Sri Lanka [version 1; peer review: 1 approved, 2 approved with reservations]. F1000Research 2021, 10:74 (https://doi.org/10.12688/f1000research.26964.1) First published: 05 Feb 2021, 10:74 (https://doi.org/10.12688/f1000research.26964.1) Latest published: 05 Feb 2021, 10:74 (https://doi.org/10.12688/f1000research.26964.1)

Introduction

Anxiety is an emotional state described as a vague, uneasy feeling, the source of which is often nonspecific. It is known to cause abnormal hemodynamics as a consequence of sympathetic, parasympathetic and endocrine stimulation¹. Barlow described anxiety as a unique and coherent cognitive-affective structure within our defensive and motivational system². At the base there is a sense of uncontrollability focused largely on possible future threats, danger, or other upcoming potentially negative events². Anxiety can only be understood by taking into account some of its cognitive aspects, particularly because a basic aspect of anxiety appears to be uncertainty³. The uncertainty regarding these situations highlights a lack of control that contributes to feelings of anxiety and makes coping more difficult⁴.

Patients awaiting surgery are more likely to develop anxiety in the pre-operative period. The study of qualitative aspects of anxiety reveals three distinct dimensions of preoperative fear: fear of the unknown, fear of feeling ill and fear for one’s life⁵. Pre-operative anxiety has a substantial negative impact on the overall outcome of surgeries. Among them, post-operative pain is the commonest complication⁶. Pre-operative anxiety has also been found to contribute to other post-operative problems such as nausea, vomiting, tachycardia, hypertension, and an increase in the risk of infection. Pre-operative anxiety in young children undergoing surgery is associated with a more painful postoperative recovery and a higher incidence of sleep related and other problems.

Studies have shown that a large proportion of surgical patients experience considerable levels of pre-operative anxiety. This figure stands at around 60%–80% in the Western population^7,8. A study conducted in Ethiopia has shown that 70.3% of patients have had anxiety during the pre-operative period^7,9. A study done among a group of patients awaiting general surgeries in Sri Lanka showed that the prevalence of anxiety was 76.7%¹.

There are certain identified factors which contribute to higher levels of pre-operative anxiety among patients, including female gender, younger age and absence of past surgical experience. The study conducted in Sri Lanka showed that females and those who have never undergone surgeries were more anxious than males and those who had previously undergone surgeries, respectively¹.

As women are identified as a vulnerable group, assessing the prevalence and factors that contribute to pre-operative anxiety among them is important as a means of identifying high risk individuals, and to plan interventions that minimize anxiety and related complications.

The objective of this study was to assess the prevalence of pre-operative anxiety levels and related factors among a group of women awaiting elective gynaecological surgeries.

Methods

Study participants

A descriptive cross-sectional study was conducted from 1/July/2018 to 1/December/2019 at the Professorial Gynaecology Unit, Ward 23, Colombo South Teaching Hospital. A total of 64 patients who were 18 and over years of age who underwent major elective gynaecological surgeries were included in the study. Patients who were admitted to the ward were checked for eligibility and once consented they were recruited into the study. Patients who underwent emergency surgeries, patients with mental illnesses or those aged below 18 years were excluded from the study sample. The sample size was determined using a non-probability sampling method where all subjects who fulfilled the criteria during the study period were enrolled into the study. Biasness of the study was controlled by excluding subjects who had previously undergone surgeries, those who had previously been exposed to the theatre environment and subjects with psychiatric disorders.

Data collection

The data was collected by an independent research person who did not have any directly involvement in the patients’ care during their period of hospital admission for the surgery. Pre-operative assessment was done on the day prior to the surgery. The anxiety level was assessed using the Sinhala version of the self-administered Amsterdam Preoperative Anxiety and Information Scale (APAIS)¹⁰, Hospital Anxiety and Depression Scale (HADS)¹¹ and Visual Analogue Scale (VAS)⁸. A pre-tested self-administered questionnaire was used to gather basic demographic data of the participants. All materials are provided as extended data¹².

The APAIS¹⁰ is a self-administered questionnaire that is widely used to assess pre-operative anxiety. It consists of six questions which assess three components of anxiety; anesthesia-related anxiety (Sum A), surgery-related anxiety (Sum S) and information desire component (Sum IDC). Combined score (Sum C) is given by the total Sum of A and Sum S. Its Sinhala version has been validated in Sri Lanka¹. In the Sinhala version, a Sum C of 11 or more indicates a significantly anxious patient. VAS is used to measure levels of anxiety. It is a 10 cm size graduated line in which the left end is marked as 0 (“no anxiety”), and the right end is taken as 10 ("maximum anxiety”). The patients were advised to evaluate their own anxiety level and then mark it on the given line. The Hospital Anxiety and Depression Scale (HADS)¹¹ is also a self-administered scale that consists of 7 questions. The total is scored out of 21. A score of 0–7 is considered as normal, 8–10 and 11–21 are considered as borderline and abnormal anxiety levels respectively.

Statistical analysis

SPSS version 17 was used to analyze the data. Pearson's correlation analysis was used to assess the correlation between each tool. A paired t-test was used to compare the mean scores of anxiety in different scales with the socio-demographic and surgical factors (age, education level, and marital status, availability of insurance coverage, living status, income and type of surgery) for the two randomized samples. A p value < 0.05 was taken as significant.

Ethical consideration

Ethical approval was obtained from the Ethics Review Committee of the Faculty of Medical Sciences, University of Sri Jayewardenepura. Informed written consent was given by each participant. Identity and privacy of the data of the participants were handled with confidentiality accordingly.

Results

A total of 64 women were included in the study¹³. The mean age of the participants was 38.03 years (SD= 13.53 years, range- 20–83 years). The majority of them (56.3%) were awaiting major surgeries. Table 1 shows the basic demographic characteristics of the participants and the type of surgery they underwent.

Table 1. Basic demographic characteristics of the participants and the type of surgery they underwent.

Variable		Number (%)
Marital status	Married	55 (85.9)
	Single	7(10.9)
	Divorced	2 (3)
Level of education	Grade 1-5	5 (7.8)
	Grade 6-10	12 (18.8)
	A/L	35 (54.7)
	Higher education	12 (18.8)
Occupation	Employed	32 (50)
	Un-employed	32 (50)
Monthly family income	<10000	3 (4.5)
	10000- 25000	9 (14.1)
	25000-50000	34 (53.1)
	50000-100000	13 (20.3)
	>100 000	5 (7.8)
Having a health insurance	Yes	19 (29.7)
	No	45 (70.2)
Living	With family	57 (89.1)
	Alone	7 (10.9)
Type of surgery	Major	36 (56.3)
	Minor	28(43.8)

Pre-operative anxiety level scored in the three scales

Table 2 summarizes the mean scores of three scales. According to the Sum C values in APAIS, 26 (40.6%) had significant pre-operative anxiety levels. According to the total score in HADS, 11 (17.2%), 6 (9.4%) and 47 (73.4%) had abnormal, borderline and normal levels of anxiety, respectively.

Table 2. Mean scores of Amsterdam Preoperative Anxiety and Information Scale, Hospital Anxiety and Depression Scale and Visual Analogue Scale.

	Components	Mean (SD)
Amsterdam Preoperative Anxiety and Information Scale	Anaesthesia related anxiety (Sum A)	4.67 (2.30)
	Surgery related anxiety (Sum S)	6.28 (2.40)
	Information Desire component (Sum IDC)	6.16 (2.72)
	Combined Anxiety component (Sum C)	10.36 (4.06)
Hospital Anxiety and Depression Scale		5.734 (4.49)
Visual Analogue Scale		3.156 (2.77)

The correlation between information desire component (Sum IDC) and the total score (Sum C) was assessed using the Pearson's correlation. There was no significant correlation between the two scores (r=0.094, p=0.462).

Comparison of three scales

Pearson's correlation was used to assess the correlations between Sum C in APAIS, HADS and VAS. All three showed significant correlation with each other; Sum C and HADS (r=0.481, p=0.000), Sum C and VAS (r=0.470, p=0.000), HAD and VAS (r=0.678, p= 0.000).

All the scores were higher in the <50 years of age category than in the older group (Table 3). Only the Sum IDC had a significant difference (t=2.875, P= 0.006). There were negative correlations between age and anxiety levels in the VAS and APAIS scales. But out of them, Sum IDC in APAIS (r=-0.416, p=0.001) and VAS scores (r=-246, p=0.050) showed significant negative correlations.

Table 3. Factors associated with anxiety.

The data is represented as mean values.

Factor		Sum A (out of 10)	Sum S (out of 10)	Sum IDC (out of 10)	Sum C (out of 20)	HADS (out of 21)	VAS (out of 10)
Age	<50	4.611	6.426	6.556*	10.740	5.703	3.333
	≥50	3.700	5.500	4.000*	8.300	5.900	2.200
Level of education	Up to O/L	4.118	6.235	5.294	9.353	6.000	2.470
	Above O/L	4.596	6.298	6.468	10.723	5.638	3.404
Marital status	Married	4.545	6.309	6.218	10.564	6.000	3.345
Marital status	Single/Divorced/Widow	4.000	6.111	5.778	9.111	4.111	2.000
Having a Health insurance	Yes	4.000	4.632*	6.421	8.631*	2.947*	2.000*
	No	4.750	6.955*	5.977	11.114*	6.818*	3.568*
Monthly income	< 50, 000	4.844	6.089	6.311	10.356	5.511	3.133
	≥ 50,000	3.666	6.889	5.889	10.611	6.555	3.388
Employment	Employed	4.406	6.281	6.625	10.218	4.906	3.156
	Unemployed	4.531	6.281	5.687	10.500	6.562	3.156
Living status	With family	4.280	6.175	6.210	10.158	5.649	3.193
	Alone	6.000	7.143	5.714	12.000	6.428	2.857
Type of surgery	Minor	5.178*	6.571	7.750*	11.178	6.107	4.107*
	Major	3.916*	6.056	4.917*	9.722	5.444	2.416*

*p<0.05 (significantly different mean values).

Except Sum IDC, all scores in APAIS, HADS and VAS were higher among the group without an insurance. Out of the sub-scores, Sum S (t=-3.716, p=0.000) and Sum C (t=-2.281, p=0.026) in APAIS, HADS (t=-3.412, p=0.001) and VAS (t=-2.135, p=0.037) had statistically higher values.

All the anxiety scores were higher in the group that underwent minor surgeries. Out of all, Sum A (t=2.237, p=0.029), Sum IDC (t=4.788, p=<0.001) scores in APAIS and VAS (t=2.520, p= 0.014) showed significantly higher values.

Education level, marital status, income, employment and living status did not show significant associations with anxiety levels (p>0.05).

Discussion

The prevalence of pre-operative anxiety in western studies varies from 30–80%¹. In this study, the prevalence of anxiety was 40.6%. However, a study performed among Sri Lankan general surgical patients using the same APAIS score and cutoff values has found a higher prevalence of 76.7% of pre-operative anxiety¹. They also found that patients with higher information desire (Sum IDC) had more anxiety, whereas in the present study there was no significant correlation between the information desire and anxiety.

There were significant positive correlations among all three scales. Past studies, including the Sri Lankan study^1,14–16, have identified various socio-demographic and surgery related factors contributing to pre-operative anxiety. In the Sri Lankan study the age, education, marital status, category of surgery (major/minor), income and having an insurance coverage were not associated with pre-operative anxiety but this study showed pre-operative anxiety scores of APAIS and VAS were negatively correlated with age¹. Out of them, VAS score and the Sum IDC score of APAIS had significant negative correlations with age. Therefore, it is likely that the information desire and levels of pre-operative anxiety reduce with ageing. Furthermore, it was also identified that not having insurance had significantly higher scores in all three scales this is despite the healthcare being free in the study setting. Paradoxically, patients who were undergoing minor surgeries had significantly higher Information desire (Sum IDC) scores and VAS scores compared to those undergoing major surgeries. These findings were contradicting to the findings of former studies¹. This may be due to less comprehensive informed consenting practiced for minor surgeries compared to major surgeries in the study setting. There were findings similar to previous studies such no significant associations between levels of pre-operative anxiety and education level, marital state, living alone or with family, employment status and income.

As this study is part of a clinical trial, prior experience in undergoing surgery or anaesthesia was an exclusion criterion. Therefore, the effect of prior experience on pre-operative anxiety was not assessed.

Conclusions

Overall, 40.6% of patients undergoing elective gynecological surgeries suffer from anxiety. Age less than 50 years, not having an insurance coverage and undergoing minor surgeries increases the pre-operative anxiety levels in this group. Therefore, screening, early identification and appropriate interventions for those with the above risk factors are may be beneficial to reduce pre-operative anxiety levels.

Data availability

Underlying data

Harvard Dataverse: Prevalence of pre-operative anxiety and associated factors among a group of women undergoing gynaecological surgeries at a single unit in a tertiary care hospital in Sri Lanka. https://doi.org/10.7910/DVN/KN3AUL¹³.

The project contains the following underlying data:

- Prevelance of Pre-operative.tab (Dataset)

Extended data

Harvard Dataverse: Prevalence of pre-operative anxiety and associated factors among a group of women undergoing gynaecological surgeries at a single unit in a tertiary care hospital in Sri Lanka. https://doi.org/10.7910/DVN/4QMH3Z¹².

The project contains the following extended data:

- F1000_Prevalence of Pre-op_Extended data.docx (Data collection sheets)

Data are available under the terms of the Creative Commons Zero "No rights reserved" data waiver (CC0 1.0 Public domain dedication).

Faculty Opinions recommended

References

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5. Kain ZN, Mayes LC, Caldwell-Andrews AA, et al.: Preoperative anxiety, postoperative pain, and behavioral recovery in young children undergoing surgery. Pediatrics. 2006 [cited 2020 Aug 19]; 118(2): 651–8. PubMed Abstract | Publisher Full Text
6. Trumper M: Bodily Changes in Pain, Hunger, Fear and Rage: An Account of Recent Researches into the Function of Emotional Excitement. Psychol Clin. 1930 [cited 2020 Aug 19]; 19(3): 100–101. Free Full Text
7. Nigussie S, Belachew T, Wolancho W: Predictors of preoperative anxiety among surgical patients in Jimma University Specialized Teaching Hospital, South Western Ethiopia. BMC Surg. 2014 [cited 2020 Aug 19]; 14(1): 67. PubMed Abstract | Publisher Full Text | Free Full Text
8. Kindler CH, Harms C, Amsler F, et al.: The visual analog scale allows effective measurement of preoperative anxiety and detection of patients' anesthetic concerns. Anesth Analg. 2000 [cited 2020 Aug 19]; 90(3): 706–12. PubMed Abstract | Publisher Full Text
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13. Jayawardane M, Gankanda WI, Gunathilake IAGMP: Prevalence of pre-operative anxiety and associated factors among a group of women undergoing gynaecological surgeries at a single unit in a tertiary care hospital in Sri Lanka. Harvard Dataverse. 2021. Harvard Dataverse, V1, UNF:6:BaYrbsHy8UMdA2D69dFkkQ== [fileUNF]; 2021. http://www.doi.org/10.7910/DVN/KN3AUL
14. Moerman N, van Dam FS, Muller MJ, et al.: The Amsterdam Preoperative Anxiety and Information Scale (APAIS). Anesth Analg. 1996 [cited 2020]; 82(3): 445–51. PubMed Abstract | Publisher Full Text
15. Nishimori M, Moerman S, Fukuhara S, et al.: Translation and validation of the Amsterdam preoperative anxiety and information scale (APAIS) for use in Japan. Qual Life Res. 2002 [cited 2020 Aug 19]; 11(4): 361–64. PubMed Abstract | Publisher Full Text
16. Apinya K, Siriporn P, Puchong L: Validity and reliability of the Amsterdam Preoperative anxiety and Information Scale (APAIS); Thai version in adult Thai pre-operative patients. Journal of Psychiatric Association of Thailand. 2009 [cited 2020 Aug 19]; 54: 86–9. Reference Source

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Author details Author details

¹ Senior Lecturer, Department of Gynaecology and Obstetrics, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka
² Acting Consultant in Gynaecology and Obstetrics, Colombo South Teaching Hospital, Kalubowila, Sri Lanka
³ Senior Registrar in Psychiatry, National Institute of Mental Health, Angoda, Sri Lanka

Madura Jayawardane
Roles: Conceptualization, Investigation, Methodology, Project Administration, Supervision, Writing – Original Draft Preparation, Writing – Review & Editing

Wedisha Gankanda
Roles: Data Curation, Formal Analysis, Investigation, Resources, Software, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing

Malsha Gunathilake
Roles: Data Curation, Formal Analysis, Investigation, Resources, Software, Validation, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing

Competing interests

No competing interests were disclosed.

Grant information

The author(s) declared that no grants were involved in supporting this work.

Article Versions (1)

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Published: 05 Feb 2021, 10:74

https://doi.org/10.12688/f1000research.26964.1

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© 2021 Jayawardane M et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Jayawardane M, Gankanda W and Gunathilake M. Prevalence of pre-operative anxiety and associated factors among a group of women undergoing gynaecological surgeries at a single unit in a tertiary care hospital in Sri Lanka [version 1; peer review: 1 approved, 2 approved with reservations]. F1000Research 2021, 10:74 (https://doi.org/10.12688/f1000research.26964.1)

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ApprovedThe paper is scientifically sound in its current form and only minor, if any, improvements are suggested

Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit.

Not approvedFundamental flaws in the paper seriously undermine the findings and conclusions

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Reviewer Report 12 May 2021

Thilina Jayarathne, Purdue University, West Lafayette, IN, USA

Approved

https://doi.org/10.5256/f1000research.29785.r82932

This is a sound cross-sectional study. The scales used in this study are validated in the same setup and internationally. Pre-operative anxiety is a source of negative surgical outcome like prolonged recovery, nausea, vomiting, increased analgesia needs and post-operative infection, ... Continue reading

This is a sound cross-sectional study. The scales used in this study are validated in the same setup and internationally. Pre-operative anxiety is a source of negative surgical outcome like prolonged recovery, nausea, vomiting, increased analgesia needs and post-operative infection, therefore this study fills several scientific gaps regarding the same. This study concludes pre-operative anxiety is common in a cohort of gynecological surgical patients in Sri Lanka whereas a similar study has proven higher prevalence in a cohort of general surgical patients appreciating the differences between specialties. The prevalence is also lower compared to worldwide data; further proving the value of studying regional differences. Paradoxical higher information desire in patients undergoing minor surgeries compared to major surgeries is an important finding which could be intervened. The results are well presented in tabular form, well discussed comparing with local and international studies.

Overall, this study could be concluded as an impressive scientific study and I recommend it to be indexed without major alterations.

Is the work clearly and accurately presented and does it cite the current literature?

Yes
Is the study design appropriate and is the work technically sound?

Yes
Are sufficient details of methods and analysis provided to allow replication by others?

Yes
If applicable, is the statistical analysis and its interpretation appropriate?

Yes
Are all the source data underlying the results available to ensure full reproducibility?

Yes
Are the conclusions drawn adequately supported by the results?

Yes

Competing Interests: No competing interests were disclosed.

Reviewer Expertise: Biologics

I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.

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Reviewer Report 22 Mar 2021

Henna Rather, Women's Division, Whipps Cross Hospital, Bart's Health NHS Trust, London, UK

Approved with Reservations

https://doi.org/10.5256/f1000research.29785.r79008

A sound cross-sectional study.
Clearer description in tabular format of inclusion and exclusion criteria and how these were derived would be beneficial.
There are a few grammatical

A sound cross-sectional study.
Clearer description in tabular format of inclusion and exclusion criteria and how these were derived would be beneficial.
There are a few grammatical errors which need to be corrected.
It would be beneficial to provide the sample questionnaires/scales (possibly as an appendix) that were given to the patient to assess anxiety levels.
An expansion on results and discussion would be advantageous. It would be beneficial to expand the results obtained of other factors affecting anxiety listed in table 3, even if not statistically significant, particularly the link between pre-operative anxiety and information desire.
It would also make the article more comprehensive if, in the discussion, some comparison is made to conclusions found in other studies on pre-operative anxiety around the world.

Is the work clearly and accurately presented and does it cite the current literature?

Partly
Is the study design appropriate and is the work technically sound?

Yes
Are sufficient details of methods and analysis provided to allow replication by others?

Yes
If applicable, is the statistical analysis and its interpretation appropriate?

Yes
Are all the source data underlying the results available to ensure full reproducibility?

Yes
Are the conclusions drawn adequately supported by the results?

Yes

Competing Interests: No competing interests were disclosed.

Reviewer Expertise: Obstetric and gynaecological research.

I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.

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Reviewer Report 23 Feb 2021

Chathurie Uththarika Suraweera, Department of Psychological Medicine, University of Colombo, Colombo, Sri Lanka

Approved with Reservations

https://doi.org/10.5256/f1000research.29785.r79007

A good study.
The language needs to be corrected at places.
Explain how the participants were checked for exclusion criteria. Justify excluding participants with mental illnesses. I

A good study.
The language needs to be corrected at places.
Explain how the participants were checked for exclusion criteria. Justify excluding participants with mental illnesses. I suggest to re-visit and expand the results section. A higher level of interpretation of the results would have added more scientific rigour to the discussion.

Is the work clearly and accurately presented and does it cite the current literature?

Yes
Is the study design appropriate and is the work technically sound?

Yes
Are sufficient details of methods and analysis provided to allow replication by others?

Yes
If applicable, is the statistical analysis and its interpretation appropriate?

Yes
Are all the source data underlying the results available to ensure full reproducibility?

Yes
Are the conclusions drawn adequately supported by the results?

Partly

Competing Interests: No competing interests were disclosed.

Reviewer Expertise: Psychiatry

I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.

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Chathurie Uththarika Suraweera, University of Colombo, Colombo, Sri Lanka
Henna Rather, Bart's Health NHS Trust, London, UK
Thilina Jayarathne, Purdue University, West Lafayette, USA

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Reviewer Report

2 Views

12 May 2021 | for Version 1

Thilina Jayarathne, Purdue University, West Lafayette, IN, USA

2 Views Cite this report Responses(0)

Approved

This is a sound cross-sectional study. The scales used in this study are validated in the same setup and internationally. Pre-operative anxiety is a source of negative surgical outcome like prolonged recovery, nausea, vomiting, increased analgesia needs and post-operative infection, therefore this study fills several scientific gaps regarding the same. This study concludes pre-operative anxiety is common in a cohort of gynecological surgical patients in Sri Lanka whereas a similar study has proven higher prevalence in a cohort of general surgical patients appreciating the differences between specialties. The prevalence is also lower compared to worldwide data; further proving the value of studying regional differences. Paradoxical higher information desire in patients undergoing minor surgeries compared to major surgeries is an important finding which could be intervened. The results are well presented in tabular form, well discussed comparing with local and international studies.

Overall, this study could be concluded as an impressive scientific study and I recommend it to be indexed without major alterations.

Is the work clearly and accurately presented and does it cite the current literature?

Yes
Is the study design appropriate and is the work technically sound?

Yes
Are sufficient details of methods and analysis provided to allow replication by others?

Yes
If applicable, is the statistical analysis and its interpretation appropriate?

Yes
Are all the source data underlying the results available to ensure full reproducibility?

Yes
Are the conclusions drawn adequately supported by the results?

Yes

Competing Interests

No competing interests were disclosed.

Reviewer Expertise

Biologics

I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.

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Reviewer Report

6 Views

22 Mar 2021 | for Version 1

Henna Rather, Women's Division, Whipps Cross Hospital, Bart's Health NHS Trust, London, UK

6 Views Cite this report Responses(0)

Approved With Reservations

A sound cross-sectional study.
Clearer description in tabular format of inclusion and exclusion criteria and how these were derived would be beneficial.
There are a few grammatical errors which need to be corrected.
It would be beneficial to provide the sample questionnaires/scales (possibly as an appendix) that were given to the patient to assess anxiety levels.
An expansion on results and discussion would be advantageous. It would be beneficial to expand the results obtained of other factors affecting anxiety listed in table 3, even if not statistically significant, particularly the link between pre-operative anxiety and information desire.
It would also make the article more comprehensive if, in the discussion, some comparison is made to conclusions found in other studies on pre-operative anxiety around the world.

Is the work clearly and accurately presented and does it cite the current literature?

Partly
Is the study design appropriate and is the work technically sound?

Yes
Are sufficient details of methods and analysis provided to allow replication by others?

Yes
If applicable, is the statistical analysis and its interpretation appropriate?

Yes
Are all the source data underlying the results available to ensure full reproducibility?

Yes
Are the conclusions drawn adequately supported by the results?

Yes

Competing Interests

No competing interests were disclosed.

Reviewer Expertise

Obstetric and gynaecological research.

I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.

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Reviewer Report

11 Views

23 Feb 2021 | for Version 1

Chathurie Uththarika Suraweera, Department of Psychological Medicine, University of Colombo, Colombo, Sri Lanka

11 Views Cite this report Responses(0)

Approved With Reservations

A good study.
The language needs to be corrected at places.
Explain how the participants were checked for exclusion criteria. Justify excluding participants with mental illnesses. I suggest to re-visit and expand the results section. A higher level of interpretation of the results would have added more scientific rigour to the discussion.

Is the work clearly and accurately presented and does it cite the current literature?

Yes
Is the study design appropriate and is the work technically sound?

Yes
Are sufficient details of methods and analysis provided to allow replication by others?

Yes
If applicable, is the statistical analysis and its interpretation appropriate?

Yes
Are all the source data underlying the results available to ensure full reproducibility?

Yes
Are the conclusions drawn adequately supported by the results?

Partly

Competing Interests

No competing interests were disclosed.

Reviewer Expertise

Psychiatry

I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.

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Prevalence of pre-operative anxiety and associated factors among a group of women undergoing gynaecological surgeries at a single unit in a tertiary care hospital in Sri Lanka

Abstract

Keywords

Introduction

Methods

Study participants

Data collection

Statistical analysis

Ethical consideration

Results

Table 1. Basic demographic characteristics of the participants and the type of surgery they underwent.

Pre-operative anxiety level scored in the three scales

Table 2. Mean scores of Amsterdam Preoperative Anxiety and Information Scale, Hospital Anxiety and Depression Scale and Visual Analogue Scale.

Comparison of three scales

Table 3. Factors associated with anxiety.

Discussion

Conclusions

Data availability

Underlying data

Extended data

References

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