Keywords
Central retinal artery occlusion, Systemic Drug Retinal Toxicity, Sildenafil, phosphodiesterase V inhibitor.
Central retinal artery occlusion, Systemic Drug Retinal Toxicity, Sildenafil, phosphodiesterase V inhibitor.
Sildenafil is a specific phosphodiesterase V inhibitor which is a widely used treatment for erectile dysfunction. Many reports have highlighted ischemic ocular side effects associated with sildenafil.1 We report herein a case of central retinal artery occlusion (CRAO), which occurred a few hours after oral sildenafil intake.
A 50-year-old Tunisian man, otherwise healthy and unemployed, presented to the ophthalmology department with sudden severe visual field constriction in the left eye (LE) of 48 hours duration preceded by severe headaches. On ophthalmic examination, visual acuity was 20/20 in the right (RE) eye and 20/25 in the left eye (LE). LE fundus examination revealed diffuse faint retinal whitening, except for central area of normal retinal color along the distribution of a perfused cilioretinal artery (Figure 1: black arrow).
Anterior segment examination of both eyes as well as fundus examination of theRE were unremarkable. LE fluorescein angiography (FA) showed no filling of the central retinal artery, regular filling of the cilioretinal artery and late retrograde filling of the central retinal vein (Figure 2: blue arrowheads).
OCT-A of the left eye at first presentation shows no flow in the microvasculature of the superficial and deep retinal capillary plexuses, except for the territory of the cilioretinal artery (Figure 3).
Only the flow in cilioretinal artery is visible.
LE central retinal artery occlusion (CRAO) with cilioretinal artery sparing was diagnosed. Echocardiogram, carotid artery imaging and blood tests were unremarkable. Further investigation revealed that a 100 mg dose of sildenafil had been taken for the first time three hours before the onset of symptoms.
Ocular massage was performed as well as sublingual isosorbide dinitrate and intravenous acetazolamide were administered. Two weeks later, reduction in retinal oedema was evident on left eye fundus examination, although there was no improvement in either visual acuity or visual field.
Various ischemic ocular events related to sildenafil have been reported. The most notable are branch retinal artery occlusion,2 acute macular neuroretinopathy,3 anterior ischemic optic neuropathy,4,5 central retinal vein occlusion6 and cilioretinal artery occlusion.7
Only two cases of CRAO with sildenafil have been reported in the literature.8,9
The patient presented here reported taking sildenafil (100 mg) a few hours before the onset of ocular symptoms and headaches. In fact, ocular side effects are directly proportional to the blood concentration of the drug, which usually appears between 15 and 30 minutes after administration, reaches a peak one to two hours later and clears halfway in 3 to 5 hours.10
As sildenafil has a high systemic vasodilator effect that reduces systemic blood pressure,11 it may decrease cerebral blood flow leading to severe headaches as experienced by our patient. Similarly, numerous clinical studies have demonstrated that sildenafil induces retinal veinous vasodilatation in vivo.12
Both the absence of risk factors for retinal vascular occlusion and the timeline of events indicates that oral sildenafil was probably a contributing factor in the development of CRAO, but its pathogenesis remains speculative. We suggest that central retinal artery occlusion occurs in the region of the lamina cribrosa where the central retinal vein and artery share a common adventitia. We speculate that sildenafil-related vasodilation of the central retinal vein causes central retinal artery compression, resulting in secondary changes, including blood flow changes, endothelial damage and platelet thrombi, leading to CRAO. This case underlines the importance of a careful drug intake investigation in cases of CRAO without obvious cause. This incident should not be overlooked by physicians and must be seriously discussed with patients requiring sildenafil, especially since most of them are at risk for ocular ischemic events. Nevertheless, this association remains poorly explained and requires further documented cases.
In summary, CRAO secondary to sildenafil is extremely rare and has only been reported in the literature twice previously. Clinicians should be aware of this risk and should avoid prescribing sildenafil in patients with a history of ischemic ocular events.
All data underlying the results are available as part of the article and no additional source data are required.
Written informed consent for publication of their clinical details and clinical images was obtained from the patient.
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Is the background of the case’s history and progression described in sufficient detail?
Yes
Are enough details provided of any physical examination and diagnostic tests, treatment given and outcomes?
Yes
Is sufficient discussion included of the importance of the findings and their relevance to future understanding of disease processes, diagnosis or treatment?
Yes
Is the case presented with sufficient detail to be useful for other practitioners?
Yes
Competing Interests: No competing interests were disclosed.
Reviewer Expertise: Ophtalmology Ocular Surface Disease , glaucoma, retinal diseases, anterior segment surgery, contactology
Is the background of the case’s history and progression described in sufficient detail?
Yes
Are enough details provided of any physical examination and diagnostic tests, treatment given and outcomes?
Yes
Is sufficient discussion included of the importance of the findings and their relevance to future understanding of disease processes, diagnosis or treatment?
Yes
Is the case presented with sufficient detail to be useful for other practitioners?
Yes
Competing Interests: No competing interests were disclosed.
Reviewer Expertise: retinal imaging, peridatric ophthalmology, cataract surgery, oculogenetics
Alongside their report, reviewers assign a status to the article:
Invited Reviewers | ||
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Version 1 01 Jun 22 |
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Provide sufficient details of any financial or non-financial competing interests to enable users to assess whether your comments might lead a reasonable person to question your impartiality. Consider the following examples, but note that this is not an exhaustive list:
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