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Case Report

Case Report: Management of Dadru Kushtha (Tinea Corporis) by Shamana Chikits

[version 1; peer review: 2 approved with reservations, 1 not approved]
PUBLISHED 08 Jan 2024
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This article is included in the Datta Meghe Institute of Higher Education and Research collection.

Abstract

Background

Skin disorders are often seen as a result of a change in lifestyle, a lack of physical activity, and inadequate nutrition. Hygiene, emotional stress, and poor eating habits are also factors to consider. Kushta is the term used in Ayurveda to describe all skin disorders which is classified as Mahakushtha (major skin disorders) and Kshudrakushtha (minor skin disorders). Dadrukushta is a type of kshudrakushta that is commonly seen in clinical practice. In Ayurveda, the signs of dadrukushta are same as those of Tinea corporis, which is explained in modern science. Tinea corporis has a wide range of clinical symptoms that are mostly dependent on the infective organisms. By treating the condition with Ayurveda’s treatment therapy produces long term Outcomes.

Aim & Objectives

Aim of this contemporary study was to assess how Ayurvedic modality shamana chikitsa works on Dadrukushta.

Case

A 27 year old male patient approached to Kayachikitsa OPD with complaints of blackish lesions with raised borders and itching over the chest and back (upper) region for 15 days having disturbed sleep which undergone treatment of shamanachikitsa (palliative care). Dadrukushta (Tinea corporis) can be dealt with shamana karma (palliative care) using internally Gandhakrasayan (Moringa ovalifolia prepared from sulphur), Panchtiktaghrita (Pancha means five, Tikta means bitter in taste. Tikta Rasapradhan Dravyas are collectively called as Panchatikta Dravyas. The five Dravyas are Azadirachta indica (Neem), Trichosanthes dioica (Patola), Solanum xanthocarpum (Kantakari), Tinofpora cordifolia (Guduchi) and Adhatoda vasica (Adulsa), fungiwin cream, Karanjataila (Pongamia pinnata oil tree), S-kin powder for local application for 45 days.

Results

The Gradation Score was 8 before treatment, after 45 days it was 0. The patient in this case study experienced relief in the symptoms.

Conclusions

The patient obtained better results by Shamanachikitsa.

Keywords

Dadrukushta, Tinea corporis, Shamana, kshudrakushta, skin disorders, kushta

Introduction

Skin is the biggest and heaviest organ in the body, spanning an average of 20 square feet. The most obvious function of the skin is to protect our internal organs from the environment, but it does so much more.1 Dermatophytes are fungi that invade and proliferate inside keratinized tissue (skin, hair, and nails).2 Trichophyton (which causes infections in the skin, hair, and nails), Epidermophyton (which causes infections on skin and nails), and Microsporum (which causes infections in the skin and nails) (which causes infections on skin and hair) are the three classes of dermatophytes. Based on their route of transmission, they have been classified as anthropophilic, zoophilic, or geophilic. Finally, depending on the people who have been affected.3 Incubation period is 1-3 weeks.4

Tinea corporis often manifests as a well-defined, strongly delineated, oval or circular, moderately erythematous, scaly patch or plaque with a raised leading edge.5 As the active boundary extends outward, the centre region becomes hypopigmented or brown and less scaly.6The margins are frequently circular and uneven. Multiple lesions gather to form polycyclic patterns.7 Ayurveda classifies all skin diseases as ‘Kushtha,’ which is further subdivided into two types: Mahakushtha (major skin disorders) and Kshudrakushtha (minor skin disorders). Dadru (Tinea corporis) is one of them.8 Acharya Charaka9 defines Dadru (Tinea corporis) as Kshudrakushtha (minor skin disorders), although Acharya Sushrut and Acharya Vagbhat define it as Mahakushtha.10 Vishamashana (incompatible food), vega vidharana (suppression of natural urges), diwaswapa (daytime sleeping), atilavana, atitikshnaahar (excessive salty or spicy food), contaminated food, drinking cold water immediately after physical work, or atapsevana (exposure to sunlight) are all factors that contribute to Kushta.11 Dadru’s principal lakshanas are Kandu (itching), Utsanna (elevated circular lesions), Mandala (circular patches), Raaga (erythema), and Pidakas (papule). Dadru samprapti is characterised by Pitta-kapha dosha vitiation and rasavaha and raktavaha strota dushti.12 Dadru is associated with Tinea/Fungal Infections because to comparable features. Tinea infections affect 5 persons out of every 1000.13 Tinea Cruris, often known as Jock Itch, is a fungal infection that affects the groin, perineum, and peri-anal region. It might appear unilaterally or bilaterally as a red, raised, and active border. The most prevalent organisms that cause ‘Tinea cruris’ are Trichophyton rubrum and Epidermophyton floccosum.14 The climate in India favours the acquisition and maintenance of mycotic infections. Dermatophyte infection is more frequent in people aged 16 to 45.15 Scalings in ‘Tinea cruris’ are varied, and vesiculation is uncommon. It frequently happens to individuals who are wearing garments made of synthetic materials, which tend to trap heat and humidity in the skin.16 It is treated in modern medicine using topical and systemic antifungal medications, as well as corticosteroids. Shodhan, Shaman, and Bahirparimarjan (topical) Chikitsa are Ayurvedic remedies for Dadru.17 In this case study, all these therapy techniques are applied.

Dadrukushta (Tinea corporis) is one of the kshudrakushta (minor skin disease) having lakshanas (symptoms) like Kandu (itiching), Atasipushpa like Pidika, Varna with Mandal (patches), Unnata Mandala (raised borders), Dirghapratana (macular rashes), Tamra Varna Pidika (copper coloured macular rashes).18 Due to vitiation of sapta dhatus (seven tissue) like three Doshas (bodily elements), Twak (skin), Rakta (blood), Mamsa (muscles) and Lasika (blood vessels) for manifestation of kushta.19 Dadrukushta is having management with shamanachikitsa (pacification).

Case report

A 27-year man working as a farmer, came with complaints of blackish lesions with raised borders and itching over the chest and back (upper) region for 15 days and having disturbed sleep because of itching. The patient was symptomless before 15 days, after that he started complaining of multiple blackish lesions with raised borders and itching over chest and back, gradually it increased and spread over chest and back (upper)region. The patient approached to MGACH & RC Salod (H) Wardha for Ayurvedic management after examination he was advised for Shamanachikitsa (palliative care). Patient had no significant past history. On examination vitals like blood pressure, temperature, heart rate and respiration rate were within normal limits.

History of present illness

Before 15 days, the patient was OK, but then he acquired round and reddish spots across his abdomen, accompanied by acute itching. He had received Allopathic treatment from a local practitioner for this but had not received satisfying results, so she came to MGAC Hospital for care.

There was no history of diabetes mellitus/insipidus, hypertension, bronchial asthma, or hypothyroidism. There was also no related family history. Except for the patient’s constipation, Ashthavidh pariksha was within normal limits. The patient was of madhyam akruti/medium body build andlocal examination revealed 4-5 circular erythematous, well-demarcated areas with vesicular eruption across the abdomen. There is no drainage from the lesion. The vital values were normal. Dadru (Tinea corporis) was identified based on clinical characteristics.

Personal history

Ahar (diet) is mostly Mixed (Veg-Non veg),nidra (sleep) isdisturbed due to itching, patient has no bad Vyasan (habits), Occupation of the patient is farmer.

AshtavidhaPariksha:

  • 1. Nadi/pulse – 74/min

  • 2. Mala/ bowel movementSaam/bowel with undigested toxins

  • 3. Mutra/micturitionSamyak/proper

  • 4. Jivha/tongue – Saam/coated

  • 5. Shabda/speech – clear/Spashta

  • 6. Sparsha/temperature on touch – rough/khara

  • 7. Druka/eyes – Prakruta/normal with no pallor or icterus

  • 8. Akruti/body build – Madhyam/average

Agni (digestive fire) = Agnimandya/poor

Bala/strength = Madhyam/average

Raktadaaba (Blood pressure) = 130/80 mm/Hg.

Skin examination

  • 1. Inspection:

    • Size shape – annular lesions

    • Color – blackish lesions

    • Lesions – scaly patch

  • 2. Palpation:

    • Moisture – dryness

    • Temperature – warmth of the skin

    • Texture – rough

Laboratory investigation

Blood routine – Normal

Samprapti Ghataka20

  • Dosha/bodily humors – Tridosha/dominance of three bodily humors

  • Dushya/elements affected by bodily humorstwaka, rakta, mamsa, lasika

  • Ama (undigested food particle) – Jatharagnijanya Ama/digestive fire related umdigested toxins

  • Agni (digestive fire) – Jatharagni

  • Srotas(inner transport system of the body) – Rasavaha, Raktavaha

  • Srotodushtiprakara/type of imbalance in inner transport system – Sanga/obstruction

  • Rogmarga(path of disease) – Bahya/external

  • Udhbhavasthana (site of location) – Amashaya/stomach

  • Vyaktasthana – twacha/skin

  • Rogaswabhava – chirakari/long-term

  • Sadhyasadhyaata – Sadhya/curable

Samprapti: (pathogenesis)

   ↓

Nidan (causative factor) sevana like Aharaja-Viharaja-Manasika (irregular food habits, Non Veg diet, consumption of alcohol), Ativyayam (excessive exercise), Atichinta (excess worry), Ratrijagarana (awakening at night).

   ↓

TridoshaPrakopa (Vitiation of all three elements)

   ↓

Twaka, Rakta, Mamsa, Lasika (Dushya)

   ↓

Sthanasamshraya in Twacha (localized in skin)

   ↓

Rukshapidika/dry lesion with kandu/itching

DadruKushta/Tinea corporis

Methods

The patient came to the OPD having the complaints of reddish patches. Written informed consent was taken from the patient before administration of conservative treatment and his detailed information was kept confidential.

Treatment plan given

Shamanachikitsa (Pacifying treatment) for 15 days comprising Gandhakrasayana, Panchatiktaghritawhich is to be given orally and fungiwin cream, Karanjataila and s-kin powder with Gomutra for localapplication (Table 1). After 15 days patient was called for followup. All medicines were continued except Gandhakrasayan, it was temporarily stopped for period of 7 days. After 7 days, the patient was asked to continue Gandhakrasayan for another 15 days with other medicines.

Table 1. Table showing Shamana Aushadhi/palliative care and Bahirparimarjana Chikitsa/external procedures.

Sr.noMedicineIngredientBotanical nameDoseAnupanaRoute
1.Gandhak RasayanaGandhaka
Godugdha (cow milk)
Twak
Ela
Patra
Nagakeshara
Guduchi
Haritaki
Amalaka
Vibhitaki
Shunthi
Bhringaraja
Ardraka
Sita (sugar syrup)
Purified Sulphur
Cinnamomumzeylanicum
Elettariacardamomum
Cinnamomumtamala
Mesuaferrea
Tinosporacordifolia
Terminalia chebula
Emblica officinalis
Terminalia bellirica
Zingiber officinalis
Eclipta alba
Zingiber officinalis
500mg twice daily after lunch and dinnerLukewarm WaterOrally
2.PanchatiktaGhritaNimba
Patola
Vyaghri
Guduchi
Vasa
Haritaki
Vibhitaki
Amlaki
Azadirachtaindica
Luffa acutangular
Solanum xanthocarpum
Tinosporacordifolia
Adhatodavasica
Terminalia chebula
Terminalia bellirica
Emblicaofficinaliss
10 ml twice daily after breakfast and dinnerLukewarm WaterOrally
3.Karanja OilKaranja
Saptachada
Langali
Snuhi
Arka
Anala
Bhringaraja
Nisha
Gomutra
VishaMurchhita Sesame oil
Pongamiapinnata
Alsoniascholaris
Gloriosa superb
Euphorbia nerifolia
Calatropisprocera
Plumbago zeylanica
Eclipta alba
Curcuma longa
Cow urine
Aconium ferox
3 times a day--------Local application
4.Fungiwin CreamShuddhagandhak
Krishna jeerak
Avalguja
Garudaphala
Bakuchi
Mathulunga
Eshwari
Madatanthika
Edagaja
Purified Sulphur
Nigella sativus
Vernonia anthelmintica
Hydnocarpuspentandra
Psoraleacorylifolia
Citrus aurantifolia
Aristolochiaindica
Lawsoniainermis
Cassia alata
Two times a day-------Local application
5.S-kin PowderManjishtha
Amalaki
Haridra
Vibhitaki
Nagarmotha
Shuddhagandhak
Rubiacordifolia
Embilica officinalis
Curcuma longa
Terminalia bellirica
Cyperusrotundus
Purified sulphur
Application before bathGomutraLocal application

Assessment criteria

Patient evaluation was based on improvements in subjective criteria such as Kandu (Itching), Raaga (Erythema), Utsanna mandala (Elevated Circular Skin, Lesion), and Pidika (Eruption), as well as images of the lesion before, during, and after therapy. Raaga (Erythema) was present prior to therapy and persisted during the first follow up, however it was eliminated on days 15 and 45, respectively, following treatment completion. Thus, following therapy, there was total improvement in all indices. The same can be observed in the photos below, which were taken before, during, and after therapy.

Observation

Tinea corporis is a Dermatophyte that causes inflammatory and non-inflammatory lesions on glabrous skin.21After 15 days treatment, symptoms subsided in patient but there were still some annular lesions present. Hence Shamanachikitsa was continued with the gap of 7 days except Gandhakrasayan. After completion of Shamanachikitsa, the patient was assessed as per the gradation of Lakshana of Dadru like Utsanna Mandala, Pidikas and Kandu as shown in Table 2 which became grade 0 after 45 days of treatment as given in Table 3. Also, the patient was symptomatically improved (Figure 1).

Table 2. Showing gradation.

Sr.noGradationsGrade 0Grade 1Grade 2Grade 3
1.Utsanna mandala (Elevated Circular Skin, Lesion)AbsentMild elevated lesionModerate elevated lesionSevere elevated lesion
2.Pidikas (acne)Absent1-3 eruptions4-7 eruptions>7 eruptions
3.Kandu (itching)AbsentMild or occasional itchingModerate or frequent itchingSevere itching

Table 3. Evaluation performed before, during, and after therapy.

GradationDay 0Day 15Day 45
Utsanna mandala (Elevated Circular Skin, Lesion)210
Pidika (acne)320
Kandu (itching)320
3db8d501-f517-4049-b827-d8f31ac107b3_figure1.gif

Figure 1. Before and after treatment image of patient diagnosed with Dadru/Tinea corporis.

Discussion

In the context of Ayurveda, kushtha is the term used to describe many types of skin illnesses, which encompass all main skin manifestations such as Tinea. The symptomatic manifestation of tinea corporis resembles that of “DadruKushtha” mentioned in Ayurvedic Samhita. This skin condition adversely affects one’s own quality of life. Ayurveda offers a viable medication for Tinea corporis.

Gandhak Rasayan’s mechanism of action: Gandhak rasayan is generally used to cure Kushtha roga. It is antimicrobial and anti-fungal in nature. It primarily affects Rakta Dhatu, causing Raktashodhana (purification of blood). Its antifungal property aids in the reduction of infection. It also performs the role of Rasayana. Its RaktaShodhaka, Vranaropak, Krumighna and Kushthagna properties reduce the Kandu, Pidika,Raaga and Daaha..22

Contents: Gandhak, Haritaki, Amalaki, Bibhitaki, Detoxified ghee, Ginger and Bhringraj. Mode of action: It is Raktashodhak, Vranaropak, Twachya, and Krumighna. It acts as a blood purifier and reduces Kandu/itching and Daha/burning sensation. Gandhaka Rasayana keeps three bodily humors, vata, pitta and kapha in equilibrium. It is a familiar, usually used formulation and specified in Kushtha.23

Mode of action of Panchatikta ghrita

Ghrita is recommended in Kushtha Chiktsa in Samhitas. Vata -Pitta Shamaka and Tvachya (improves complexion) properties of Panchatikta Ghrita helps to alleviate Kushthaghna (skin disease).24

Mode of action of Karanja oil

Karanja oil is mentioned in Visarpa Chikitsa in BhaishajyaRatnavali. It consists of Krumighna (antifungal and antibacterial activities), Kandughana, Vranaropaka and Vranashodhaka properties.25Local application is beneficial for rapid absorption and reduction of kharata/dryness.26

Mechanism of action of S-kin Powder

Ingredients have antibacterial, antifungal, and antimicrobial characteristics, as well as Raktashodhaka (blood purification) and Vranaropak (wound healing) properties. While application of this powder Gomutra should be mixed which enhance its absorption property.27

Mode of action of Fungiwin Cream

Fungiwin contains Shuddha gandhak, Krishna jeerak, Avalguja etc which acts as a Krimighna, Rasayana Deepan, Pachan, Vishagna as well as Balya.it acts on all the Dhatus by acting on Dhatwagni. Hence help to formation of new cells in body. It also works as Antifungal with the gap of 7 days rejuvenation hence used in various skin diseases.

Dadru is Pitta-Kapha dominance according to Acharya Charak and Vagbhata, and Kaphapradhan according to Acharya Sushruta. Rasa and Rakta are both involved in the samprapti. Kushta is characterised in Samhita by repeated Shodhana and Shamana medications with Kushtaghna, Krumighna, and Kandughna characteristics. In addition, Bahiparimarjana Chikitsa (local application of medications) in the form of lepa and oil was recommended for improved results.28 In certain cases, the Ayurvedic therapy technique produces excellent outcomes. Pitta and Kapha are the most vitiated Doshas with Rasa and Rakta Dhatu, while Lasika and Tvak are Dushyas in Dadru.29‘Nidana Parivarjana’ is regarded as the initial stage in Dadru management. Untidiness of the body, sharing cloths (towels), and so on should be avoided depending on Nidana’s involvement.30 Dadru, in both its acute and chronic forms, causes physical and emotional distress in humans, as itching and other symptoms persist throughout the day.31 Ayurvedic medicine is a medical discipline that provides lasting cures by employing internal and external medicine. The qualities of Kushthaghna, Kandughna, and Krimighna might aid in the safe and successful treatment of Dadru patients.32 The skin is the index of a person’s mind; in daily life, people consume incompatible diets and dietary habits, which lead to many diseases, among which skin disorders are prominent, and Dadru is one of them. Dadru Kushtha is a very infectious Kaphapitta Pradhana Tridoshaja Aupasargika Roga. Dadru, while treatable, has a stubborn character. If the course of treatment is not carefully managed, remission and relapses are common; thus, treatment should be started as soon as feasible. Ayurvedic therapy focuses on avoiding etiological variables (Nidana Parivarjanam) and breaking down pathology (Samprapti Vighatana), which leads to Dhatu Samya.33

Conclusion

Tinea corporis is associated with DadruKushtha based on signs and symptoms. Chikitsa is planned in Kushtharoga, depending on the severity of Roga. ShamanaChikitsa is administered in Alpadoshaavastha (least severe). Dadru kushta is a kind of Kshudrakushta, according to Acharya Charak, and Mahakushtha according to Acharya Sushruta and Acharya Vagbhata. Tinea corporis or dermatophytosis may be involved. Because it is an infectious illness, personal hygiene is critical in its treatment. From this case study it can be concluded that use of Chikitsa upakramas described in Ayurveda like Shodhana (Nitya virechana with Gomutra siddha haritaki), Shamana (formulations like Arogyavardhini vati, Gandhak rasayan) and Bahiparimarjana (lepa of S-kin powder in gomutra and local application of Karanj oil) are effective in the management of Dudru kushta.

Consent

Written informed consent for publication of their clinical details and/or clinical images was obtained from the patient.

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Panda M, Deshmukh S and Thakre T. Case Report: Management of Dadru Kushtha (Tinea Corporis) by Shamana Chikits [version 1; peer review: 2 approved with reservations, 1 not approved]. F1000Research 2024, 13:26 (https://doi.org/10.12688/f1000research.142589.1)
NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article.
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Key to Reviewer Statuses VIEW
ApprovedThe paper is scientifically sound in its current form and only minor, if any, improvements are suggested
Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit.
Not approvedFundamental flaws in the paper seriously undermine the findings and conclusions
Version 1
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PUBLISHED 08 Jan 2024
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Reviewer Report 11 Sep 2024
Manjunath M. Shenoy, Department of Dermatology, Yenepoya Medical College, Yenepoya (Deemed to be university), Mangalore, Karnataka, India 
Not Approved
VIEWS 2
Dear author/s,
Happy to observe a case report on treatment of tinea corporis, however, please note my following comments.
1.Is this a novel treatment modality or is it a known form of treatment?
2. Having treated a lot ... Continue reading
CITE
CITE
HOW TO CITE THIS REPORT
Shenoy MM. Reviewer Report For: Case Report: Management of Dadru Kushtha (Tinea Corporis) by Shamana Chikits [version 1; peer review: 2 approved with reservations, 1 not approved]. F1000Research 2024, 13:26 (https://doi.org/10.5256/f1000research.156156.r245763)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
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Reviewer Report 24 Apr 2024
Paradkar Hemant, APM Ayurveda Mahavidyalaya, Sion, Mumbai, India 
Approved with Reservations
VIEWS 12
Introduction: The introduction offers a comprehensive overview of Tinea corporis (Dadru kushtha) and its manifestations, including its clinical presentation, etiology, and conventional treatment approaches in both modern medicine and Ayurveda. However, enhancing its readability could be achieved by breaking down ... Continue reading
CITE
CITE
HOW TO CITE THIS REPORT
Hemant P. Reviewer Report For: Case Report: Management of Dadru Kushtha (Tinea Corporis) by Shamana Chikits [version 1; peer review: 2 approved with reservations, 1 not approved]. F1000Research 2024, 13:26 (https://doi.org/10.5256/f1000research.156156.r265859)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
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Reviewer Report 26 Feb 2024
Ghazala Javed, Central Council for Research in Unani Medicine, New Delhi, India 
Approved with Reservations
VIEWS 11
The case report lists management of Dadrukushta which is considered to be similar to Tines corporis. Somewhere it should be mentioned how the diagnosis of Tinea corporis was made? 

Also, why 03 topical applications are being used? ... Continue reading
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CITE
HOW TO CITE THIS REPORT
Javed G. Reviewer Report For: Case Report: Management of Dadru Kushtha (Tinea Corporis) by Shamana Chikits [version 1; peer review: 2 approved with reservations, 1 not approved]. F1000Research 2024, 13:26 (https://doi.org/10.5256/f1000research.156156.r245754)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
  • Author Response 13 Apr 2024
    Dr. Manisha Panda, Kaumarbhritya, Datta Meghe Institute of Higher Education and Research, Wardha, 442001, India
    13 Apr 2024
    Author Response
    Respected reviewer,
    Diagnosis was made by signs and symptoms, gradations are also mentioned. 
    So, kindly consider. Yes Ayurvedic references are present for topical lotions.

    Yours sincerely,
    Manisha Panda
    Competing Interests: no
  • Author Response 13 Apr 2024
    Dr. Manisha Panda, Kaumarbhritya, Datta Meghe Institute of Higher Education and Research, Wardha, 442001, India
    13 Apr 2024
    Author Response
    Respected reviewer,
    Diagnosis was done by observing signs and symptoms similar to Tinea  corporis.
    Ayurvedic references are followed for all medications.

    Yours Sincerely,
    Manisha Panda
    Competing Interests: no
COMMENTS ON THIS REPORT
  • Author Response 13 Apr 2024
    Dr. Manisha Panda, Kaumarbhritya, Datta Meghe Institute of Higher Education and Research, Wardha, 442001, India
    13 Apr 2024
    Author Response
    Respected reviewer,
    Diagnosis was made by signs and symptoms, gradations are also mentioned. 
    So, kindly consider. Yes Ayurvedic references are present for topical lotions.

    Yours sincerely,
    Manisha Panda
    Competing Interests: no
  • Author Response 13 Apr 2024
    Dr. Manisha Panda, Kaumarbhritya, Datta Meghe Institute of Higher Education and Research, Wardha, 442001, India
    13 Apr 2024
    Author Response
    Respected reviewer,
    Diagnosis was done by observing signs and symptoms similar to Tinea  corporis.
    Ayurvedic references are followed for all medications.

    Yours Sincerely,
    Manisha Panda
    Competing Interests: no

Comments on this article Comments (0)

Version 1
VERSION 1 PUBLISHED 08 Jan 2024
Comment
Alongside their report, reviewers assign a status to the article:
Approved - the paper is scientifically sound in its current form and only minor, if any, improvements are suggested
Approved with reservations - A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit.
Not approved - fundamental flaws in the paper seriously undermine the findings and conclusions
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