ALL Metrics
-
Views
-
Downloads
Get PDF
Get XML
Cite
Export
Track
Case Report

Case Report: Giant bronchogenic cyst compressing the pericardium and the lung hilum

[version 1; peer review: 1 approved with reservations]
PUBLISHED 23 Apr 2024
Author details Author details
OPEN PEER REVIEW
REVIEWER STATUS

Abstract

Introduction: The bronchogenic cyst is a congenital anomaly of the trachea and the bronchi resulting in a malformation that develop in the bronchial tree, most often in the middle mediastinum. It is a benign pathology, often asymptomatic, however in the case of a large bronchogenic cyst, signs of compression of the intra-thoracic organs appear and early surgery is necessary to avoid complications.
Case presentation:  A 49-year-old patient was referred to our department with dry cough, dyspnea and chest tightness progressing for six months. Radiological exploration concluded that a giant bronchogenic cyst, 90 mm in diameter, was very probable. Surgery was performed via a right posterolateral thoracotomy. Intraoperatively, there was a large cystic formation 100mm*80 mm of the middle mediastinum in intimate contact with the origin of the right pulmonary artery, the lower right pulmonary vein as well as the right atrium exerting a compressive effect on the bronchi. The lesion was firmly adhered to the pericardium. The cystic was ‘en bloc’ resected in totality. The postoperative course was uncomplicated. Histological examination confirmed diagnosis of a bronchogenic cyst. The patient was asymptomatic throughout the follow-up period.
Clinical discussion:  Apart from the possibility of malignant degeneration, a bronchogenic cyst can increase in size and become huge causing serious complications.  Despite the predictive diagnostic value of imaging, definitive diagnosis of a bronchogenic cyst is confirmed by surgical excision and pathological examination.
Conclusions:  Surgery is almost obligatory especially if the cyst is above a certain size (about 60 mm) and in the case of giant bronchogenic cysts.

Keywords

giant bronchogenic cysts, surgical excision, complications, case report

Introduction

Bronchogenic cysts (BCs) are defined as uncommon congenital anomalies.1 They account for 60% of mediastinal cyst lesions.1 Mediastinal BCs have often been described arising from an abnormality in tracheobronchial tree budding between the third and sixth weeks of gestation.2,3 In adult patients, BCs are frequently asymptomatic2,46 and are often randomly discovered during a chest X-ray.2 Whenever they become symptomatic, surgical resection becomes highly recommended. Typically, BCs are oval in shape, of diameter between 20 to 120 mm.2

The aim of our case, which was operated on in The Public Hospital of Abdarrahman Mami, Tunis, is to insist in the good timing of surgery of BCs in order to avoid compressive complications due to increasing size and to ensure easier operation.

Case report

Patient information

A 49-year-old patient was referred to the Thoracic Surgery Department of Abderrahmane Mami Hospital in April 2021 with a dry cough, dyspnea and chest tightness progressing for six months. The patient had a medical history of diabetes mellitus, and arterial hypertension. She had no surgical history or family history of bronchogenic cysts.

Clinical findings

Physical examination revealed no abnormalities.

Diagnostic assessment

Chest radiography showed a mass overlapping the cardiac silhouette (Figure 1). A computed tomography (CT) scan of the chest revealed a round homogeneous cystic mass 96 mm * 80 mm in diameter, occupying the middle mediastinum between the aortic arch and right pulmonary artery in sub-carine of liquid density not enhanced after injection of a contrast product. Thoracic magnetic resonance imaging (MRI) showed a cystic formation of homogeneous signal with thin wall in T2 hypo signal, evoking a bronchogenic cyst (Figure 2).

abfc0295-6276-461f-9ecd-951d116004fc_figure1.gif

Figure 1. Finding on the chest X-ray: An oval opacity overlapping the cardiac silhouette.

abfc0295-6276-461f-9ecd-951d116004fc_figure2.gif

Figure 2. Magnetic resonance imaging: Formation in T2 Hyposignal between right pulmonary artery, inferior pulmonary vein, tracheal bifurcation and descending aorta.

Therapeutic intervention

Surgery was performed via a right posterolateral thoracotomy. Intraoperatively, there was a large cystic formation 100 mm*80 mm of the middle mediastinum in intimate contact with the origin of the right pulmonary artery, the lower right pulmonary vein as well as the right atrium exerting a compressive effect on the adjacent organs especially the pericardium (Figure 3A). After aspiration of a yellow liquid content and viscous consistency, the cystic was ‘en bloc’ resected in totality (Figure 3B).

abfc0295-6276-461f-9ecd-951d116004fc_figure3.gif

Figure 3. (A) Giant cyst located in the middle mediastinum (B) After excision: the tumor lay between the right pulmonary artery, inferior pulmonary vein, tracheal bifurcation, and descending aorta.

Follow-up and outcomes

The postoperative course was uncomplicated with removal of the drains on the fourth post-operative day. The patient was discharged from the hospital on May 16, 2021, on the fifth postoperative day. Histological examination confirmed diagnosis of a bronchogenic cyst. The patient was asymptomatic throughout the follow-up period.

Discussion

BCs are relatively uncommon.1 They occur not only in pediatric patients, but also in adults.2 BCs are typically found near the large airways in the mediastinum, often just posterior to the carina, although they may be attached to the oesophagus or even inside the pericardium.3 BCs are thought to originate early in lung bud development, before bronchus formation.3 BCs contain clear fluid or less commonly, haemorrhagic secretions or air. Cases of intra-pericardial BCs are very rare in the literature.5 We present a distinctive case in which a giant BC was discovered compressing the pulmonary artery and pericardium in a very important way.

BCs are diagnosed incidentally because patients do not show symptoms.56 However, when BCs are huge, they sometimes bring about life-threatening complications including rupture, infections, an haemorrhage and compression of the surrounding structures.68 Those complications can be suggested by the presence of symptoms such as cough, fever, haemoptysis, dyspnea and chest pain. If the cyst is giant with invasion of the pericardium, there is an imminent risk of intra-pericardial rupture and pericardial effusion that can lead to cardiac tamponade and exacerbation of the initial symptoms.5

On radiography, BCs appear as a spherical opacity, non-calcified, with smooth outlines.2 A CT scan is very useful in preoperative diagnosis of BCs to ascertain the precise size and in order to show the relationship of the cyst to adjacent mediastinal structures.29 Thus, it shows homogeneous, smooth, solitary, round or ovoid masses usually located in middle mediastinum. The CT scan density of BCs can vary from typical water density to high density related to increased calcium content, anthracotic pigment, blood, or greater protein content of the fluid.9 MRI may provide specific diagnostic confirmation in regard to BCs and allows the limits within the pericardium and the large vessels to be specified.9 In Tunisia, hydatid cysts are common, and they are the first differential diagnosis to be suggested. In such contentious cases, only surgery associated with histological examination can affirm one of the two diagnoses.

Surgical resection is the most approved treatment option of BCs.68 The evolutionary possibilities of the cyst justify the legitimacy and the need of complete removal of this lesion.4 Despite the predictive diagnostic value of imaging, definitive diagnosis of BCs is confirmed by surgical excision and pathological examination.9 Different authors suggest various approaches such as CT guided or mediastinoscopic drainage, video-assisted thoracic surgery (VATS) or open thoracotomy. The choice of one or the other is according to the condition of the patient and characteristics of malformation (e.g., size, extension).1,6 Generally, considering the risk of serious complications and even malignancy degeneration, BCs require complete resection and should be performed every time when the diagnosis is suspected especially since the patient’s follow up is uncertain.1,5 Specifically, for giant BCs, surgical resection is recommended as early as possible in order to avoid serious complications due to the increasing size.5 In cases where there is a close relationship between the BC and the pericardium, it is important to consider emergency surgery in order to avoid a sudden rupture of the cyst in the pericardium that can lead to tamponade or acute pericarditis.10 The prognosis after complete excision is excellent.8 Incomplete excision will lead to a high recurrence rate and to the potential for more serious sequelae.8 Trans-tracheal and percutaneous drainage of the cyst are proposed by some authors as alternatives to surgery, but they are not widely accepted because of possible cyst recurrence.8

In our case, surgery was laborious because the cyst was firmly adhered to the pericardium, right pulmonary artery, and the lower right pulmonary vein with a very important compression of the bronchi. The surgical challenge was to do a radical excision without injuring the vascular and bronchial elements. We succeeded in performing this by dissecting the wall of the cyst step by step and we had the choice of approaching the patient with open thoracotomy.

Conclusions

Apart from the progressive malignant potential, BCs can increase in size becoming huge cysts and causes serious complications. Surgical excision is almost obligatory especially when the cyst is a certain size and in the case of giant BCs. The advent of VATS increasingly supports the idea of adhering to surgical treatment choice in the event of a bronchogenic cyst whatever the size. A careful analysis of the radiologic appearance allows us to better assess the limits of the BC and in order to prepare for sometimes laborious surgery. Incomplete surgical excision is associated with high late recurrence of the cyst.

Limitations

Given the rarity of the BC, limited data exist on the surgical treatment of a giant BC and management is based on expert opinion. However, our study is limited to one case report and we haven’t significant information as would be the case with a series of patients.

Consent

Written informed consent for publication of their clinical details and clinical images was obtained from the patient.

Comments on this article Comments (0)

Version 1
VERSION 1 PUBLISHED 23 Apr 2024
Comment
Author details Author details
Competing interests
Grant information
Copyright
Download
 
Export To
metrics
Views Downloads
F1000Research - -
PubMed Central
Data from PMC are received and updated monthly.
- -
Citations
CITE
how to cite this article
Abdennadher M, Ben Mansour A, Zribi H et al. Case Report: Giant bronchogenic cyst compressing the pericardium and the lung hilum [version 1; peer review: 1 approved with reservations]. F1000Research 2024, 13:373 (https://doi.org/10.12688/f1000research.131641.1)
NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article.
track
receive updates on this article
Track an article to receive email alerts on any updates to this article.

Open Peer Review

Current Reviewer Status: ?
Key to Reviewer Statuses VIEW
ApprovedThe paper is scientifically sound in its current form and only minor, if any, improvements are suggested
Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit.
Not approvedFundamental flaws in the paper seriously undermine the findings and conclusions
Version 1
VERSION 1
PUBLISHED 23 Apr 2024
Views
1
Cite
Reviewer Report 29 May 2024
Manoj Madhusudan, Aster RV Hospital, Bengaluru, India 
Approved with Reservations
VIEWS 1
1. The authors have mentioned that physical examination was completely normal. Is that the case with a huge BC compressing the pericardium and hilum?
2. Was a per-op lung function or an echocardiogram performed?
3. Can the authors ... Continue reading
CITE
CITE
HOW TO CITE THIS REPORT
Madhusudan M. Reviewer Report For: Case Report: Giant bronchogenic cyst compressing the pericardium and the lung hilum [version 1; peer review: 1 approved with reservations]. F1000Research 2024, 13:373 (https://doi.org/10.5256/f1000research.144502.r271904)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.

Comments on this article Comments (0)

Version 1
VERSION 1 PUBLISHED 23 Apr 2024
Comment
Alongside their report, reviewers assign a status to the article:
Approved - the paper is scientifically sound in its current form and only minor, if any, improvements are suggested
Approved with reservations - A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit.
Not approved - fundamental flaws in the paper seriously undermine the findings and conclusions
Sign In
If you've forgotten your password, please enter your email address below and we'll send you instructions on how to reset your password.

The email address should be the one you originally registered with F1000.

Email address not valid, please try again

You registered with F1000 via Google, so we cannot reset your password.

To sign in, please click here.

If you still need help with your Google account password, please click here.

You registered with F1000 via Facebook, so we cannot reset your password.

To sign in, please click here.

If you still need help with your Facebook account password, please click here.

Code not correct, please try again
Email us for further assistance.
Server error, please try again.