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Case Report

Case Report: Pneumocephalus after labor epidural anesthesia

[version 1; peer review: 2 approved, 1 approved with reservations]
PUBLISHED 22 Jul 2014
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OPEN PEER REVIEW
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Abstract

Lumbar epidural anesthesia is commonly used for labor analgesia. The 'loss-of- resistance' to air technique (LORA) is generally employed for recognition of the epidural space. One of the rare complications of this technique is pneumocephalus (PC). Here we describe the case of a parturient who developed a frontal headache when locating the epidural space using LORA. On the second day after epidural injection, the patient exhibited occipital headaches with gradual worsening. Computed tomography scans of the brain indicated PC. Following symptomatic treatment, our patient was discharged on the 13th day. We concluded that the amount of air used to identify the epidural space in LORA should be minimized, LORA should not be used after dural puncture and the use of saline avoids PC complications.

Keywords

Epidural anesthesia, complication, pneumocephalus

Introduction

Lumbar epidural anesthesia is a commonly used technique for analgesia during labor. The complications often associated to this technique include unilateral analgesia, extended epidural blockade, unplanned puncture of the dura or of a blood vessel, post-puncture dural headache (PDPH), subdural blockade, placement of the catheter out of the epidural space and neurological complications1. The ‘loss-of-resistance’ to air technique (LORA) is commonly employed for recognition of the epidural space. Nevertheless, one of its rare complications is pneumocephalus (PC)2.

Cases of PC following neuroaxial anesthesia have been described either after an epidural using the LORA technique or after spinal anesthesia3,4. The development of PC after spinal anesthesia is exceptionally rare5,6. PC symptoms are difficult to distinguish from other complications of the epidural technique such as PDPH or neurotoxicity. Diagnosis relies on clinical impression and brain tomography (CT-scan)2. Our goal is to report the case of a patient who presented PC following labor epidural anesthesia.

We attempted to approach the patient and the patient’s family to obtain informed consent for publication of this report, However we decided to abandon telephone contact after numerous unsuccessful attempts. The Institutional Review Board at Complexo Hospitalario Universitario A Coruna determined that approval of the case report was not required.

Clinical case

A 34 year old healthy Caucasian parturient ASA II, G1P0 was admitted at 38 weeks of gestation. Her clinical history included no allergies to medications, no relevant family history, mild bicuspid aortic valve stenosis, cervical aortic arch and mild postductal coarctation of the aorta. She was not taking any medications. She presented occasional asymptomatic palpitations at rest (few seconds long). Her cardiopathy was compensated and well controlled during pregnancy.

At 4–5 cm of cervical dilatation, at the request of analgesia, a lumbar epidural was proposed for management of labor pain. The patient was monitored with ECG, SpO2, non-invasive blood pressure (NIBP) every 5 minutes and a peripheral vessel catheter was in situ. Puncture was performed at the L4–L5 interspace with a 18 G Tuohy epidural needle (Perifix® 401 Braun Germany) (80 mm/3¼" long) via the median approach with the patient in the sitting position. After locating the epidural space using the LORA technique (approximately 3 ml of air), the patient developed a sudden intense frontal headache. No neurological, haemodynamic changes or breathing symptoms were detected. The needle was withdrawn without cerebrospinal fluid (CSF) flashback. The cephalalgia improved gradually ceasing several minutes later. An epidural catheter was introduced afterwards (Perifix® 401 Braun Germany, close-end, three lateral holes) in the L3–L4 interspace with the patient in the sitting position, after locating the epidural space using loss of resistance to saline (LORS). We confirmed its appropriate location by checking that CSF had not been aspirated prior to local anesthetic injection. The test dose of 3 ml of bupivacaine 0.25% and epinephrine resulted negative. An initial bolus of 5 ml of bupivacaine 0.25% and 50 mcg of fentanyl was administered and a continuous infusion of ropivacaine 0.18% in addition to 1 mcg of fentanyl per ml was programmed at 7 ml/hour. This process was incident-free, being the epidural analgesia correct and labor with normal evolution.

On the second day postpartum, the patient presented occipital headaches which increased on standing, accompanied by tinnitus, nausea and vomiting, with gradual worsening. We found no alterations in the neurological examination. We decided conservative treatment with rest, NSAIDs, intravenous hyperhydration and 300 mg of oral caffeine twice daily, showing mild clinical improvement. However, on the 6th day after delivery, due to mild clinical worsening, and suspecting iatrogenic PC vs. PDPH, a brain CT-scan was performed. The CT scan revealed air in the temporal horns and right frontal horn of the lateral ventricle, showing a PC in the subarachnoid space and ventricles that was responsible for mild ventricular dilation (Figure 1 and Figure 2). A subdural collection that could correspond to an inflammatory reaction was also observed. At all times the neurological examination was normal. We consulted the Neurosurgery Service, which considered the PC not significant and recommended to continue with the conservative treatment and repeat the CT in 48–72 hours or if neurological changes occurred.

152c7a78-00c4-4fd2-8746-fba0af43474a_figure1.gif

Figure 1. Axial CT scan shows the presence of a gas bubble in the ventricular system following dural puncture, in the right frontal cistern horn of the lateral ventricle.

152c7a78-00c4-4fd2-8746-fba0af43474a_figure2.gif

Figure 2. Axial CT scan shows the presence of a gas bubble in the ventricular system following dural puncture, in both temporal cistern horns.

Despite treatment, at the 8th day after puncture, the patient’s symptoms worsened at night with severe frontal headaches (Visual Analog Scale 6) and an increase in tinnitus. She was afebrile, the vital signs were unremarkable, and she had no focal neurological deficits. A control CT scan showed a mild regression of the PC in the ventricular system, but demonstrated persistence of the subdural collection. We decided to continue with the conservative treatment and performed control blood tests (routine hematological; liver and kidney function tests; serum electrolytes; coagulation profile).

On the 13th day after delivery, the follow-up was uneventful, the patient showed no abnormalities at the neurological examination and her vital signs were normal. The patient was finally discharged from the anesthesiology department being completely asymptomatic.

Discussion

PC is relatively common in neurosurgery7 and neuroradiology8,9. It can be caused by trauma10 or infections11,12. It may develop after lumbar puncture, epidural steroid injection, or Valsalva’s maneuver1315. The development of PC after spinal or epidural anesthesia is extremely infrequent. The incidence of PC after epidural steroid injections or epidural anesthesia is unknown, and only few cases per year are described in the literature16,17. Most cases of PC due to epidural techniques have been associated with LORA, as described in our case report.

PC, an unusual consequence of evident or unnoticed accidental dural puncture3,4,18, develops from the injection of air into the subarachnoid or subdural space and cranial migration19. PC is not often followed by symptoms, but among those, headache is the most frequent20,21. The appearance of other symptoms, such as signs of space-occupying lesions (focal neurologic deficits including cranial nerve palsies19,20, or diverse motor signs) or augmented intracranial pressure and cardiovascular instability may develop depending on the spread and extent of intracranial air22. Headache is caused by the fast brain motion resulted from air injection and meningeal irritation21. Most cases consist of abrupt intense frontotemporal cephalea5,23,24, as in our case study, having a premature beginning (same day) and commonly concluding within 5 days. It is exacerbated by motion and may not be alleviated by lying down2. Roderick et al. outlined that 2 ml of air injected into the subarachnoid space was sufficient to provoke a symptomatic PC5.

In case of PDPH, due to CSF outflow, the pain is exacerbated by sitting or standing and is alleviated by lying down, having a characteristic occipital, frontal and post-orbital situation. It happens more often 24 to 48 hours after dural puncture25 and is longer lasting than in PC2. Although there may be subtle clinical differences with PC, their symptoms usually are interchangeable so the differential diagnosis must be done through CT.

A number of techniques to find the epidural space have been defined26. LORA and LORS are the most common methods used2. Potential inconveniences of using saline comprise the difficulty to ascertain a meningeal puncture27. On the other hand, if air is forced quickly by digital pressure, false positives may result, or gas embolism, subcutaneous emphysema28 or multiradicular syndromes29.

Accidental dural puncture is not always evident, as also shown in our case. Okell and Springge30 described a 0.6% incidence of dural punctures in epidural anesthesia. These punctures were acknowledged by the loss of CSF, by aspiration through the catheter, by hypotension after injection of a test dose, and retrospectively. Hardy31 reported that an epidural catheter cannot easily be passed through the dura, but the arachnoid can be penetrated smoothly. The author deduced that when a catheter goes into the subarachnoid space it is due to its initial subdural placement and movement to the arachnoid, as the first hole in the dura yields migration of the catheter2. Air introduced into the subdural space is more painful than in the subarachnoid space and reaches rapidly the head, because of its low pressure and diminished capacitance32,33.

These findings explain the sequence in our case. We found no evidence of dural puncture with CSF flashback with the needle insertion at the L4-L5 interspace, but the dura had already been penetrated, allowing the passage of air likely into the subdural space and causing the abrupt headache. Despite our uncertainty regarding dural puncture, we correctly avoided LORA and used LORS for the following attempt to localize the epidural space.

In our case, PC was diagnosed from the CT scan. While subdural space is not straightly connected to the subarachnoid space34, it is annexed to the floor of the third ventricle in the cranial cavity from the lower border of the second sacral vertebra35,36.

The treatment of PC consists on administration of 40–100% oxygen in the supine position37. This is to favor the reabsorption of intracranial air by intensifying the diffusion concentration gradient for nitrogen between the air collection and the surrounding cerebral tissue38. Nitrous oxide should be avoided to prevent the expansion of PC39. In addition, we should administer aggressive hydration, caffeine, or analgesics40,41. Epidural infusion or blood patch have no effect on PC3,19.

There is usually reabsorption of the air within 3–5 days from the epidural injection and patients commonly improve without any neurologic abnormalities. Our patient was discharged after clinical-radiologic resolution on the 13th day. If tension PC occurs, a neurosurgical emergency treatment may be necessary21,23,42.

In conclusion, the way to minimize the likelihood of PC when performing epidural block with the loss of resistance technique is to use saline instead of air43,44. When air is used, we should minimize its extent. In addition, LORA should not be used after dural puncture.

After epidural block, and particularly when dural puncture is performed, the patient should be monitored carefully. We should identify that the headache from PC after epidural anesthesia occurs commonly immediately after puncture. Likewise, we should recognize that symptoms of PC are similar to those of PDPH and that a differential diagnosis is established by imaging techniques. Lastly, we should be able to assess that PC may be spontaneously absorbed, managed with symptomatic treatment.

Consent

After numerous unsuccessful attempts to contact the patient and the patient’s family to obtain informed written consent for publication of this report, the Institutional Review Board at our Institution determined that approval of the case report was not required.

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VERSION 1 PUBLISHED 22 Jul 2014
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Nistal-Nuño B and Gómez-Ríos MÁ. Case Report: Pneumocephalus after labor epidural anesthesia [version 1; peer review: 2 approved, 1 approved with reservations]. F1000Research 2014, 3:166 (https://doi.org/10.12688/f1000research.4693.1)
NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article.
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Key to Reviewer Statuses VIEW
ApprovedThe paper is scientifically sound in its current form and only minor, if any, improvements are suggested
Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit.
Not approvedFundamental flaws in the paper seriously undermine the findings and conclusions
Version 1
VERSION 1
PUBLISHED 22 Jul 2014
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Reviewer Report 14 Aug 2014
Jean Eloy, Department of Anesthesiology, Rutgers New Jersey Medical Center, Newark, NJ, USA 
Approved
VIEWS 17
The case report: “Pneumocephalus after epidural anesthesia” is a well written manuscript. The Hypothesis is sound and the originality of the manuscript evident. The report is also relevant to clinical practice, shows appropriate methodology and is properly referenced. However, in ... Continue reading
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CITE
HOW TO CITE THIS REPORT
Eloy J. Reviewer Report For: Case Report: Pneumocephalus after labor epidural anesthesia [version 1; peer review: 2 approved, 1 approved with reservations]. F1000Research 2014, 3:166 (https://doi.org/10.5256/f1000research.5014.r5559)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
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26
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Reviewer Report 04 Aug 2014
Jean Charchaflieh, Department of Anesthesiology, Yale University, New Haven, CT, USA 
Ivan Velickovic, SUNY Downstate Medical Center, Brooklyn, NY, USA 
Approved
VIEWS 26
The authors provided an excellent description of a case of pneumocephalus (PC) after epidural catheterization, without evident dural puncture, with very informative discussion of the pathophysiology, symptomatology and management. The authors discussed briefly some of the advantages and disadvantages of ... Continue reading
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CITE
HOW TO CITE THIS REPORT
Charchaflieh J and Velickovic I. Reviewer Report For: Case Report: Pneumocephalus after labor epidural anesthesia [version 1; peer review: 2 approved, 1 approved with reservations]. F1000Research 2014, 3:166 (https://doi.org/10.5256/f1000research.5014.r5543)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
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Reviewer Report 29 Jul 2014
Richard Smiley, Department of Anesthesiology, Columbia University, New York, NY, USA 
Approved with Reservations
VIEWS 21
The authors have reported an interesting case of headache after a lumbar epidural procedure. There is value in reminding anesthesiologists of the potential for pneumocephalus (PC) when air is used for the loss-of-resistance procedure. Their description makes it clear that ... Continue reading
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CITE
HOW TO CITE THIS REPORT
Smiley R. Reviewer Report For: Case Report: Pneumocephalus after labor epidural anesthesia [version 1; peer review: 2 approved, 1 approved with reservations]. F1000Research 2014, 3:166 (https://doi.org/10.5256/f1000research.5014.r5538)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.

Comments on this article Comments (0)

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VERSION 1 PUBLISHED 22 Jul 2014
Comment
Alongside their report, reviewers assign a status to the article:
Approved - the paper is scientifically sound in its current form and only minor, if any, improvements are suggested
Approved with reservations - A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit.
Not approved - fundamental flaws in the paper seriously undermine the findings and conclusions
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