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Opinion Article
Revised

Soil-transmitted helminths are a serious but understudied health concern in South Africa, requiring immediate attention from the scientific community.

[version 2; peer review: 1 approved, 1 approved with reservations]
PUBLISHED 11 Sep 2014
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This article is included in the Neglected Tropical Diseases collection.

Abstract

Parasitic roundworms and flatworms, defined broadly as helminths, are estimated to infect over 1 billion people worldwide, and are particularly prevalent in developing, resource-strained communities. The consequences of these infections are immense and wide reaching, resulting in massive reductions in local and global economic productivity and contributing to millions of deaths per year. Helminth diseases can also reduce vaccine efficacy and heighten morbidity rates of other serious illnesses, including tuberculosis and HIV/AIDS. Here, we argue that South Africa, which has one the highest rates of both HIV/AIDS and helminth infections on earth, needs to allocate more energy and resources into studying soil-transmitted helminths. Using PubMed and GenBank statistics, we show that the current South African research output on soil-transmitted helminths pales in comparison to that on HIV and tuberculosis. Basic research on helminth biology as well as on the social and environmental effects associated with infections could greatly reduce the burden of HIV/AIDS, tuberculosis, and other major illnesses in South Africa and beyond. The onus is on scientists, funding agencies, and governing bodies to channel efforts into studies on soil-transmitted helminths.

Keywords

Ascaris lumbricoides; helminthiasis; parasitic worms; South African helminths; Trichuris trichiura

Revised Amendments from Version 1

We have revised Table 1 to take into account the comment from Tali Cassidy, with regards to the data from the WHO PCT database.  The data for soil-transmitted helminthiases are now correctly stated to represent the population of children (<15 years old) needing preventative treatment as of 2012 (previously ‘number of children (<15 years old) infected’).

To read any peer review reports and author responses for this article, follow the "read" links in the Open Peer Review table.

Commentary

Over a billion people in sub-Saharan Africa and developing regions of Asia and the Americas have helminthiasis—a devastating category of diseases caused by parasitic worms (helminths)13, such as roundworms (nematodes), tapeworms (cestodes), or flukes (trematodes). Parasitic helminths can infect the intestinal tract, urinary tract, and blood of humans, and other mammals, leading to serious illness and in some cases permanent disability or death. The most common types of helminthiasis are intestinal and caused by soil-transmitted roundworms, including Ascaris lumbricoides and Trichuris trichiura, and the hookworms Necator americanus and Ancylostoma duodenale36. Schistosomiasis and lymphatic filariasis, commonly known as bilharzia and elephantiasis, respectively, are other less common kinds of helminthiases3.

Most people with helminthiasis live in marginalized, resource-limited communities. Sadly, school-aged children and women of childbearing age, including adolescent girls, are among the most susceptible to chronic helminth infections and are at a greater risk of morbidity than members of other groups4. Because of its insidious, chronic nature, helminthiasis often goes untreated, leading to far-reaching social and economic consequences. Those infected with helminths show decreased performance at school and work and are predisposed to permanent disability, cardiovascular disease, and premature death. Helminthiases can also reduce vaccine efficacy and accentuate the morbidity rates of other serious diseases, such as malaria, tuberculosis, and HIV/AIDS3,79. Indeed, a number of studies on African populations have shown that helminth infections increase morbidity rates in HIV/AIDS patients as a result of systemic immune activation8,1012.

Reducing the number of helminthiasis infections should, therefore, decrease disease burden and pressure on the health care system, especially in countries with high rates of HIV/AIDS. South Africa, which has the highest prevalence of HIV in the world and the highest rate of HIV-associated tuberculosis has channeled significant resources into fighting both of these diseases, but devotes comparatively little money and effort into combating helminthiasis13,14. Moreover, of the estimated 6.1 million people living with HIV in South Africa as of 2012, 0.41 million were under the age of 15 (http://www.unaids.org/en/regionscountries/countries/southafrica/), and are, thus, highly susceptible to helminth infections.

Mass drug administration (MDA) programs, involving cooperation between government health departments and major pharmaceutical companies, provide low-cost or free drugs for the treatment of various diseases and are one of the most cost-effective global public health control measures in existence5. Moreover, many of the MDA programs are targeted at preschool- and school-aged children; however, children who do not attend school can be overlooked1. Currently, a major obstacle to implementing cost-effective controls for helminthiasis is the lack of knowledge on the geographical distribution of infection and co-infection3,15 — a problem that could be easily and quickly solved with some basic research initiatives into helminthiasis. Again, given recent evidence of helminths developing drug resistance1,16, an alternative to MDA becomes a necessity. Vaccine (which doesn’t presently exist) research and development may thus be the best long-term strategy for sustained control and treatment of helminthic infections5,17.

To gauge South African research output on HIV and tuberculosis versus that on soil-transmitted helminths, we explored PubMed publication numbers and GenBank deposition data (Table 1). In the past year (July 2013 to June 2014), more than 400 journal articles have been published on HIV in South Africa, most of which have at least one author who is affiliated with a South African research institute. These journal articles cut across diverse HIV research areas, including diagnosis, treatment, vaccine trials, co-infections, mother-to-child transmission, and drug resistance. In comparison, there are very few published studies on soil-transmitted helminths in South Africa (mainly in Western Cape and Kwazulu-Natal). Within the past twelve months, only three journal articles on soil-transmitted helminths in South Africa appeared in PubMed, one of which was lead-authored by a researcher from a Cameroonian institute1820 (Table 1). What’s more, there are thousands of HIV genome sequences from South Africans deposited in GenBank but not a single nucleotide sequence exists from a South African soil-transmitted helminth (Table 1). Given these statistics it appears that there is an overall lack of research on helminthiasis, both within and outside of South Africa.

Table 1. Statistics on the prevalence, publication rate, and number of genetic sequences for HIV, tuberculosis, and soil-transmitted helminths in South Africa.

HIVMycobacterium
tuberculosis
Soil-transmitted
helminthiases (STH)
Population of children (<15 years old) infected
(HIV) or needing preventative treatment (STH)
as of 2012
410,000a39,000b3,200,000c
Publications available in PubMed (July 2013
to June 2014)d
447743
Numbers of above that are lead-authored by
researchers in South African institutionsd
394662
Nucleotide sequences available in NCBId3,22522,1750

dStatistics based on keyword searches in PubMed and GenBank using “HIV”, “Mycobacterium tuberculosis”, “Ascaris lumbricoides”, “Trichuris trichiura”, “Necator americanus”, and “Ancylostoma duodenale.” In addition to “South Africa”, each keyword was used to retrieve data (using the ‘Advanced Search Builder’ option) from the respective databases. For PubMed search, “2013/07/01 to 2014/06/30” was indicated as the Publication date. Search results were edited manually to remove incorrect entries. The incorrect entries were mostly articles that matched the main search terms but were from other African countries.

The onus is on scientists, funding agencies, and governing bodies to channel efforts into studies on soil-transmitted helminths. Basic research on helminth evolution, cell biology, genetics, and diversity as well as on the social and environmental effects associated with infections could greatly reduce the burden of HIV/AIDS, tuberculosis, and other major illnesses in South Africa and beyond. Helminth research also represents the first logical step in achieving the 2013 World Health Assembly (WHA) resolution to eliminate soil-transmitted helminths by 20201,3.

Comments on this article Comments (2)

Version 2
VERSION 2 PUBLISHED 11 Sep 2014
Revised
Version 1
VERSION 1 PUBLISHED 04 Sep 2014
Discussion is closed on this version, please comment on the latest version above.
  • Author Response 10 Sep 2014
    David Smith, Department of Biology, University of Western Ontario, London, Ontario, N6A 5B7, Canada
    10 Sep 2014
    Author Response
    We have revised Table 1 to take into account the comment from Tali Smith, with regards to the data from the WHO PCT database.  The data for soil-transmitted helminthiases are now ... Continue reading
  • Reader Comment 09 Sep 2014
    Tali Cassidy, Boston University School of Public Health, South Africa
    09 Sep 2014
    Reader Comment
    The prevalence of STHs in the table presented above is incorrect. It refers to the WHO PCT database, which give the figure of children AT RISK for STHs. i.e. those ... Continue reading
  • Discussion is closed on this version, please comment on the latest version above.
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Ajoge HO, Olonitola SO and Smith DR. Soil-transmitted helminths are a serious but understudied health concern in South Africa, requiring immediate attention from the scientific community. [version 2; peer review: 1 approved, 1 approved with reservations]. F1000Research 2014, 3:209 (https://doi.org/10.12688/f1000research.4812.2)
NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article.
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Open Peer Review

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ApprovedThe paper is scientifically sound in its current form and only minor, if any, improvements are suggested
Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit.
Not approvedFundamental flaws in the paper seriously undermine the findings and conclusions
Version 2
VERSION 2
PUBLISHED 11 Sep 2014
Revised
Views
11
Cite
Reviewer Report 09 Mar 2015
Chikwe Ihekweazu, National Institute for Communicable Diseases, Johannesburgh, South Africa 
Approved
VIEWS 11
This article makes an important case and raises important issues. However, I am not sure how much children out of school is a challenge in South Africa. Also - I think the authors should have acknowledged the incredibly difficult challenge ... Continue reading
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HOW TO CITE THIS REPORT
Ihekweazu C. Reviewer Report For: Soil-transmitted helminths are a serious but understudied health concern in South Africa, requiring immediate attention from the scientific community. [version 2; peer review: 1 approved, 1 approved with reservations]. F1000Research 2014, 3:209 (https://doi.org/10.5256/f1000research.5664.r7877)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
Views
28
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Reviewer Report 08 Oct 2014
James Smith, School of Social and Political Science, University of Edinburgh, Edinburgh, UK 
Approved with Reservations
VIEWS 28
The article makes a reasonable point around the thorny issue of research prioritisation - although I think conflating actual numbers of child HIV infections with children at risk of infection of STH is not an ideal comparison given relative differences in ... Continue reading
CITE
CITE
HOW TO CITE THIS REPORT
Smith J. Reviewer Report For: Soil-transmitted helminths are a serious but understudied health concern in South Africa, requiring immediate attention from the scientific community. [version 2; peer review: 1 approved, 1 approved with reservations]. F1000Research 2014, 3:209 (https://doi.org/10.5256/f1000research.5664.r6286)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.

Comments on this article Comments (2)

Version 2
VERSION 2 PUBLISHED 11 Sep 2014
Revised
Version 1
VERSION 1 PUBLISHED 04 Sep 2014
Discussion is closed on this version, please comment on the latest version above.
  • Author Response 10 Sep 2014
    David Smith, Department of Biology, University of Western Ontario, London, Ontario, N6A 5B7, Canada
    10 Sep 2014
    Author Response
    We have revised Table 1 to take into account the comment from Tali Smith, with regards to the data from the WHO PCT database.  The data for soil-transmitted helminthiases are now ... Continue reading
  • Reader Comment 09 Sep 2014
    Tali Cassidy, Boston University School of Public Health, South Africa
    09 Sep 2014
    Reader Comment
    The prevalence of STHs in the table presented above is incorrect. It refers to the WHO PCT database, which give the figure of children AT RISK for STHs. i.e. those ... Continue reading
  • Discussion is closed on this version, please comment on the latest version above.
Alongside their report, reviewers assign a status to the article:
Approved - the paper is scientifically sound in its current form and only minor, if any, improvements are suggested
Approved with reservations - A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit.
Not approved - fundamental flaws in the paper seriously undermine the findings and conclusions
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