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Research Note

Challenges in implementing the 2015 BASHH guidelines for the appropriate use of post-exposure prophylaxis for HIV following sexual exposure

[version 1; peer review: 1 approved, 2 approved with reservations]
PUBLISHED 09 Jun 2016
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Abstract

The use of post exposure prophylaxis for human immunodeficiency virus (HIV) following sexual exposure (PEPSE) was retrospectively audited in an inner city genitourinary clinic against the 2015 national guidelines by the British Association for Sexual Health and HIV (BASHH). One-hundred out of a total of 101 patients (99%) had a baseline HIV test done. 82.1% (n=83) of patients were given PEPSE prescriptions fitting within recommended indications lower than the 90% target set by BASHH. 84.2% (n=85) of patients had PEPSE administered within 72 hours lower than the 90%. 61.4% (n=62) of patients were known to have completed four weeks of PEPSE lower than the 75% target. 61.4% (n=62) of patients were screened for sexually transmitted infections (STIs) lower than the 90% target. 59.4% (n=60%) of patients had post-PEPSE HIV bloods slightly lower than the 60% target.

Keywords

HIV, post exposure prophylaxis for HIV, BASHH, antiretrovirals, sexually transmitted infections

Introduction

Post-exposure prophylaxis for HIV involves taking antiretrovirals by human immunodeficiency virus (HIV)-negative individuals for four weeks, after a suspected or known exposure to HIV to reduce the risk of transmission1,2. In 2015 the British Association for Sexual Health and HIV updated national guidelines on the appropriate use of post exposure prophylaxis after sexual exposure to HIV (PEPSE)3. -- The guidelines provide indications for when PEPSE use; is recommended; can be considered; or is not appropriate. It also recommends PEPSE use within 72 hours; baseline HIV testing, appropriate sexually transmitted infection (STI) testing, and completion of four weeks of PEPSE with follow up HIV bloods after completion of PEPSE. BASHH have specified auditable targets for these recommendations, and this retrospective audit compares the use of PEPSE in our genitourinary clinic against these recommendations.

Method

A retrospective case note review was carried out at Walsall Centre of Sexual Health. One-hundred one patients who were coded as having received PEPSE between June 2013 and September 2015 were identified on the computer system. No permission was required to conduct the study and publish these results. Notes of these patients were reviewed and data regarding; the indication of PEPSE administration; time since exposure; investigations carried out; completion of four weeks of PEPSE and whether the patient had follow up investigation were uploaded onto a Microsoft Excel database.

Results

The results of 101 patients who received PEPSE were analysed (Table 1). 48.5% (n=49) of patients were male, 61% (n=30) of the male patients were bi-sexual/homosexual.

Table 1. Auditable targets for prophylaxis for human immunodeficiency virus (HIV) following sexual exposure.

Patients
Number%BASHH
recommended
target %
Baselines HIV Test 10099100
Indication
Recommended
Consider
53
30
52.5
29.7
90
Not Recommended1312.9
No documentation55.0
Exposure to PEP Time
<72 hours8584.290
>72 hours1110.9
Not documented55
Completion of 4
weeks of PEPSE
Yes6261.475
No1413.9
Unknown2524.8
STI Screening
Hep B
immunity/booster
/Syphilis
101100
Chlamydia/gonorrhoea6261.490
Post-PEPSE HIV Test
6059.460

Baseline HIV tests were done in 99% of patients (n=100). One patient did not have baseline HIV tests. This patient initially visited a local emergency department where she received PEPSE without HIV testing. This patient subsequently came to our genitourinary medicine clinic one week later and had a HIV test done. Baseline HIV test was done on the first visit to the clinic in all 100 cases.

52.5% (n=53/101) of prescriptions for PEPSE were given under recommended indications by BASHH (Table 2), and 29.7% (n=30/101) of patients were given PEPSE under indications where BASHH state they can be considered. All of the patients in the considered category in this audit were female patients who had been sexually abused. In total, 82.2% of patients were given PEPSE for recommended/considered indications lower than the 90% target. 5% (n=5/101) of patients had no documented reason for starting PEPSE.

Table 2. Patients that fit into recommended indications (n=83).

Number of patients%
Patients that fit recommended
Indications
HIV +ve partner VL Unknown
or >40
2024.1
Men who have sex with men
(MSM) High prevalence/
unknown
1821.7
Sexual Assault3137.3
Needle stick Injury1518.1

84.2% (n=85) of patients received PEPSE within 72 hours of exposure lower than the 90% target. 13.9% (n=14) of PEPSE was prescribed after 72 hours since exposure, while 5% (n=5) of patients had no documentation of when the exposure occurred.

61.4% (n=62) of patients had documentation showing that they had completed four weeks of PEPSE, lower than the 75% target. 13.9% (n=14) of patients did not complete four weeks of PEPSE while 24.8% (n=25) of patients had no documentation regarding whether they had completed four weeks of PEPSE.

59.4% (n=60%) of patients had post-PEPSE HIV bloods slightly lower than the 60% target.

All 100 patients that had baseline HIV bloods taken had appropriate investigations into hepatitis B and syphilis. However 61.4% (n=62) of patients were screened for chlamydia and gonorrhoea lower than the 90% target. None of the patients who had come for PEPSE after needle stick injury had testing for gonorrhoea and chlamydia, and not taking into account these patients 73% of patients had screening for chlamydia and gonorrhoea.

Discussion

The majority of patients prescribed PEPSE where given so under indications that were deemed compliant with BASHH guidelines and within 72 hours of the suspected exposure. All but one of these patients had baselines HIV bloods taken, and appropriate testing for syphilis and hepatitis B, with post-PEPSE follow-up testing levels being near the BASHH target.

Documentation regarding whether patients were taking or discontinuing PEPSE was lacking. There was also difficulty determining whether patients who did not attend after their initial visit had completed their PEPSE course.

One particular guideline that we found difficulty in reaching was screening for chlamydia and gonorrhoea, especially in patients coming in after needlestick injuries. Often times it is either not considered suitable or the patient declines the screening as they do not feel they are at risk. Screening should always be encouraged and there should be documentation that the screening tests have been declined if that is case.

Another issue is patients not visiting for follow-ups. Often screening for chlamydia and gonorrhoea is delayed until after the window period for investigations to identify these organisms. Follow-ups are also important for identifying whether the patient is compliant with the antiretrovirals, and for post-PEPSE HIV blood tests.

Carrying out an audit against the BASHH guidelines have highlighted areas in our clinical practice which need improvement. In response to this audit we have created clear proformas for prescribing PEPSE which include; whether the indication the patient is coming in with fits with BASHH guidelines; whether the exposure was less than 72 hours ago, and a list of the relevant investigations that should be considered. Proformas for follow-up have also been made to assess whether the patient is completing the course of PEPSE and having follow-up bloods after completion of therapy. Training has been given to educate all staff on the indications for PEPSE prescribing, the need to identify HIV status and viral load of source, the need to have accurate documentation, to offer rapid-HIV testing, and fourth generation HIV testing for post-PEPSE follow-up. We have also decided to get patients to book their follow-up appointment during their initial visit to the clinic. We will then send SMS reminders the day before the follow-up appointment to remind patients to attend. We plan to carry out a re-audit in one year.

Data availability

All raw data are provided in the tables above.

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Khattak MF. Challenges in implementing the 2015 BASHH guidelines for the appropriate use of post-exposure prophylaxis for HIV following sexual exposure [version 1; peer review: 1 approved, 2 approved with reservations]. F1000Research 2016, 5:1313 (https://doi.org/10.12688/f1000research.8952.1)
NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article.
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Open Peer Review

Current Reviewer Status: ?
Key to Reviewer Statuses VIEW
ApprovedThe paper is scientifically sound in its current form and only minor, if any, improvements are suggested
Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit.
Not approvedFundamental flaws in the paper seriously undermine the findings and conclusions
Version 1
VERSION 1
PUBLISHED 09 Jun 2016
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Reviewer Report 07 Jun 2017
Rachel Beanland, Independent Public Health Specialist, Gaillard, France 
Approved with Reservations
VIEWS 2
This is an interesting report of a clinical audit conducted to assess the implementation of UK BASHH guidelines on Post Exposure Prophylaxis following sexual exposure. The paper provides a clear summary of the methods and results compared to national guidelines. ... Continue reading
CITE
CITE
HOW TO CITE THIS REPORT
Beanland R. Reviewer Report For: Challenges in implementing the 2015 BASHH guidelines for the appropriate use of post-exposure prophylaxis for HIV following sexual exposure [version 1; peer review: 1 approved, 2 approved with reservations]. F1000Research 2016, 5:1313 (https://doi.org/10.5256/f1000research.9631.r23142)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
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Reviewer Report 26 May 2017
Paul Volberding, UCSF-GIVI Center for AIDS Research, University of California, San Francisco, San Francisco, CA, 94121, USA 
Approved
VIEWS 3
This is an interesting report of the use of post-exposure prophylaxis following possible sexual exposure to HIV in a UK retrospective cohort. While it shows that British guidelines were generally followed well, it of course leaves open the question of ... Continue reading
CITE
CITE
HOW TO CITE THIS REPORT
Volberding P. Reviewer Report For: Challenges in implementing the 2015 BASHH guidelines for the appropriate use of post-exposure prophylaxis for HIV following sexual exposure [version 1; peer review: 1 approved, 2 approved with reservations]. F1000Research 2016, 5:1313 (https://doi.org/10.5256/f1000research.9631.r22154)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
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Reviewer Report 20 Apr 2017
Theresa Marié Rossouw, Department of Immunology, Institute for Cellular and Molecular Medicine, University of Pretoria, Pretoria, South Africa 
Approved with Reservations
VIEWS 6
There are some language and grammatical errors that need attention.
 
The link provided to the BASHH guidelines is for the draft document and not the final version.
 
More detail about the context is need ... Continue reading
CITE
CITE
HOW TO CITE THIS REPORT
Rossouw TM. Reviewer Report For: Challenges in implementing the 2015 BASHH guidelines for the appropriate use of post-exposure prophylaxis for HIV following sexual exposure [version 1; peer review: 1 approved, 2 approved with reservations]. F1000Research 2016, 5:1313 (https://doi.org/10.5256/f1000research.9631.r22009)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.

Comments on this article Comments (0)

Version 1
VERSION 1 PUBLISHED 09 Jun 2016
Comment
Alongside their report, reviewers assign a status to the article:
Approved - the paper is scientifically sound in its current form and only minor, if any, improvements are suggested
Approved with reservations - A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit.
Not approved - fundamental flaws in the paper seriously undermine the findings and conclusions
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