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Research Note

Vasomotor symptoms monitoring with a commercial activity tracking watch

[version 1; peer review: 1 approved, 1 approved with reservations]
PUBLISHED 20 Dec 2017
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Abstract

Personal fitness/health tracking devices that include electrodermal activity sensors enable tracking of vasomotor symptoms (hot flashes).  Multiple conditions are associated with vasomotor symptoms.  This article describes nighttime tracking of vasomotor symptoms for an individual over a two-year period.  This volunteer was a participant in a longitudinal study on volunteers wearing physiological monitors.  Personal tracking of vasomotor symptoms will provide new insights on the differences between conditions and impacts on individual’s health.

Keywords

Vasomotor symptoms, hot flashes, menopause, galvanic skin response, GSR, electrodermal activity, EDA, physiological monitoring, health tracking

Introduction

Continuous tracking of electrodermal activity (EDA), also known as galvanic skin response (GSR), values with commercial fitness devices for individuals with vasomotor symptoms (hot flashes) provides a path forward for future studies with fine resolution monitoring. This can improve upon the current reliance on the use of personal diaries (Regestein et al., 2015). There are multiple conditions associated with vasomotor symptoms including menopause/early menopausal transition (Hale et al., 2014), medications (Quinestrol, tramadol, etc.), chemotherapy and Tamoxifen, hyperthyroidism, infections (Inflammatory Bowel Disease – IBD, etc.), and more. Multiple studies have characterized hot flashes in premenopausal and menopausal women using self reported methods, laboratory polysomnographic recording, and some specially designed devices (Freedman, 2014). However, it is difficult for an individual to track and accurately report nighttime vasomotor symptoms without the aid of a physiological monitoring device (Freedman, 2014). Emerging commercial and custom devices with EDA meters will greatly facilitate the nighttime monitoring of hot flashes for individuals for more informative longitudinal studies of conditions with associated vasomotor symptoms. This report illustrates the potential fine-resolution monitoring of nighttime vasomotor symptoms using commercially available activity-tracking devices with an EDA sensor.

Methods

MIT Lincoln Laboratory conducted a longitudinal study on volunteers wearing physiological monitors (June 15 2014 to October 2 2016). The study protocol and written consent form were reviewed and approved by the MIT Committee on the Use of Humans as Experimental Subjects (COUHES). The commercial devices in the study include the Basis B1 watch and Basis Peak watch monitors for tracking heart rate, sleep with predicted sleep phases (light, deep, and REM – rapid eye movement), activity, skin temperature, and perspiration (EDA/GSR) without the use of electrodes or gel. The Basis B1 and Peak watches are no longer commercially available, but similar devices with EDA/GSR sensors are available.

Vasomotor symptoms started disrupting the sleep of a female volunteer on November 23, 2015, calling attention to their occurrence. After November 23, 2015, the volunteer started personally logging the occurrence of vasomotor symptoms, noting that the recorded EDA signals reflected the logged hot flash intensities and durations.

Results

Figure 1 shows data from eight days around this time period. Freedman (Freedman, 1989) identified a good agreement between an increase of 2 μS/cm in 30 s time period with volunteer self-reports for vasomotor symptoms. For November 15th, the EDA median value was 6.8e-4 μS/cm and average value of 4.9e-2 4 μS/cm. For November 16th, the EDA median value was 6.8e-4 μS/cm and average value of 1.9e-2 μS/cm. Across all nights tracked, the EDA median value was 3.7e-4 μS/cm illustrating baseline EDA values for this volunteer. The longitudinal data collected indicates that the volunteer’s vasomotor symptoms may have been occurring as early as June 2014, but went unnoted until higher intensity vasomotor symptoms caused sleep disruptions. A review of all sleep time data indicates an increase in sleep interruption minutes as reported by Basis (52/1957=2.9% for EDA range 10-15 μS/cm and 15/311=4.8% for EDA range 15-25 μS/cm compared to 3823/258119=1.5% for EDA < 1 μS/cm). This is consistent with volunteer observations. Nights like November 23 and 24, 2015 cause sleep disruptions. Figure 2 illustrates over two years of nighttime EDA values while this volunteer was sleeping. Starting in December 2015, the volunteer started self-tracking EDA values and vasomotor symptoms. Daytime peaks were associated with both exercise and vasomotor symptoms. The volunteer reports that daytime vasomotor symptoms and sleep-disrupting vasomotor symptoms were consistent with recorded EDA peaks but they did not record these observations. Nighttime EDA peaks well above baseline values were observed in clusters from June 2014 until November 2016. Note that nights with low EDA values still occur frequently for this volunteer, indicating nights free of vasomotor symptoms. The volunteer did not take hormone or nonhormonal formulations for the treatment of vasomotor symptoms. Note that the volunteer’s Basis B1 watch was replaced with a Basis Peak watch in August 2015.

ec2d6003-96eb-4176-8c6d-70c073085020_figure1.gif

Figure 1. Eight nights illustrating nighttime hot flashes tracked with Basis Peak watch.

Vertical axis shows EDA values in μS/cm.

ec2d6003-96eb-4176-8c6d-70c073085020_figure2.gif

Figure 2. Volunteer’s nightly Basis watch EDA values for 1.5 years.

Heatmap of each minute of volunteer’s nighttime Basis EDA values tracked with Basis B1 or Basis Peak watch and line plot of nightly maximum EDA values in μS/cm.

Discussion

Longitudinal studies of large numbers of volunteers will provide new foundations for tracking vasomotor symptoms associated with menopause and other conditions. Continuous tracking of EDA values with readily available commercial tracking devices will provide a path forward for future fine-resolution longitudinal studies of conditions associated with vasomotor symptoms. Insights into understanding and treating vasomotor symptoms will be greatly advanced by these longitudinal studies, as the different causes of vasomotor symptoms may vary in intensities and durations. EDA is also reported as a sensitive index of sympathetic nervous system activity (Poh et al., 2010). In addition, commercial devices with EDA meters will be valuable personal monitoring tools to premenopausal and menopausal women and individuals experiencing vasomotor symptoms.

Data availability

The nighttime EDA values tracked are available in Ricke, Darrell, 2017, "GSR nights", doi: 10.7910/DVN/ONAUUZ, Harvard Dataverse.

Consent

Written informed consent was obtained from the volunteer for the publication of her details.

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Ricke DO. Vasomotor symptoms monitoring with a commercial activity tracking watch [version 1; peer review: 1 approved, 1 approved with reservations]. F1000Research 2017, 6:2155 (https://doi.org/10.12688/f1000research.13348.1)
NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article.
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Key to Reviewer Statuses VIEW
ApprovedThe paper is scientifically sound in its current form and only minor, if any, improvements are suggested
Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit.
Not approvedFundamental flaws in the paper seriously undermine the findings and conclusions
Version 1
VERSION 1
PUBLISHED 20 Dec 2017
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Reviewer Report 01 May 2018
JoAnn E Manson, Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital,  Harvard Medical School,  Boston, MA, USA 
Deirdre Tobias, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA 
Approved
VIEWS 3
The article by D.O. Ricke provides details of the experience of an individual research participant in a longitudinal study that involved wearing physiological monitors, allowing a comparison of personal tracking of nighttime vasomotor symptoms (VMS) with the parallel capture of ... Continue reading
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CITE
HOW TO CITE THIS REPORT
Manson JE and Tobias D. Reviewer Report For: Vasomotor symptoms monitoring with a commercial activity tracking watch [version 1; peer review: 1 approved, 1 approved with reservations]. F1000Research 2017, 6:2155 (https://doi.org/10.5256/f1000research.14488.r33626)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
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Reviewer Report 06 Feb 2018
Nanette Santoro, Department of Obstetrics and Gynecology, University of Colorado, Denver, CO, USA 
Approved with Reservations
VIEWS 3
The author provides information on a single research study participant who incidentally experienced vasomotor symptoms while testing a physiological monitor in what is presumably a separate study. Changes in electrodermal activity appeared to correlate with self reported night time vasomotor ... Continue reading
CITE
CITE
HOW TO CITE THIS REPORT
Santoro N. Reviewer Report For: Vasomotor symptoms monitoring with a commercial activity tracking watch [version 1; peer review: 1 approved, 1 approved with reservations]. F1000Research 2017, 6:2155 (https://doi.org/10.5256/f1000research.14488.r29732)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
  • Author Response 19 Feb 2018
    Darrell Ricke, Group 48 Bioengineering Systems and Technologies, MIT Lincoln Laboratory, 244 Wood Street, Lexington, 02420-9108, USA
    19 Feb 2018
    Author Response
    The article on the parent study has now been released: Ricke DO, Harper J, Shcherbina A et al. Integrated Biomedical System [version 1; referees: awaiting peer review]. F1000Research 2018, 7:162 ... Continue reading
COMMENTS ON THIS REPORT
  • Author Response 19 Feb 2018
    Darrell Ricke, Group 48 Bioengineering Systems and Technologies, MIT Lincoln Laboratory, 244 Wood Street, Lexington, 02420-9108, USA
    19 Feb 2018
    Author Response
    The article on the parent study has now been released: Ricke DO, Harper J, Shcherbina A et al. Integrated Biomedical System [version 1; referees: awaiting peer review]. F1000Research 2018, 7:162 ... Continue reading

Comments on this article Comments (0)

Version 1
VERSION 1 PUBLISHED 20 Dec 2017
Comment
Alongside their report, reviewers assign a status to the article:
Approved - the paper is scientifically sound in its current form and only minor, if any, improvements are suggested
Approved with reservations - A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit.
Not approved - fundamental flaws in the paper seriously undermine the findings and conclusions
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