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MacDonald AB. _Borrelia Spirochetes_ in human blood: fluoresence _in situ_ hybridization - FISH. F1000Posters 2015, 6:110 (poster)

Borrelia Spirochetes in human blood: fluoresence in situ hybridization – FISH

Alan B MacDonald¹

Published 11 Feb 2015

Author Affiliations

¹ Department of Research, The Dr Paul H Duray MD Research Endowment Trust, Inc, USA

Copyright © 2015 MacDonald AB. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Published 11 Feb 2015

Borrelia Spirochetes in human blood: fluoresence in situ hybridization – FISH
[version 1; not peer reviewed]

Alan B MacDonald¹

Author Affiliations

¹ Department of Research, The Dr Paul H Duray MD Research Endowment Trust, Inc, USA

Abstract

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No competing interests were disclosed

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Elena Cook

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24 Mar 2015

My comment for some reason became corrupted and my main point truncated. I was trying to underline the enormous significance of the fact that these Molecular Beacon DNA probes have found evidence of spirochaete bacteria in autopsy Alzheimer's disease brain... READ MORE

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Elena Cook

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17 Feb 2015

For the past two decades, reliance on a flawed two-tier serodiagnostic system for Borrelia infections has led to untold numbers of patients being misdiagnosed and abandoned to their fate. Now with Beacon Probes, we have a far superior tool at... READ MORE

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Raphael Stricker

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17 Feb 2015

Raphael B. Stricker Marianne J. Middelveen We have now used Dr. MacDonald's molecular beacon DNA probes in three clinical studies of Lyme disease: a case of granulomatous hepatitis associated with Borrelia burgdorferi infection, a detailed examination... READ MORE

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Peter Mayne

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12 Feb 2015

FISH methods are now a preferred method for the serial measurements of the chronic myelogenous leukaemias BCR/ABL2 and related family of mutations In malignant clonal populations of bone marrow leukemia cells. This is because the exact DNA sequences of the... READ MORE

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Eva Sapi

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12 Feb 2015

The strength of this poster to show that molecular beacons could be very powerful tools to find Borrelia especially in bodily fluids. There is also a very important point that beacon probes are capable demonstrating all the forms of Borrelia... READ MORE

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Alan MacDonald

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11 Feb 2015

ADDENDUM : VALIDATION STUDIES COMPLETED TO RATIFY THE SPECIFICITY OF MOLECULAR BEACON DNA PROBES IN THIS PRESENTATION. Validation is required for purposes of Quality Control when a New laboratory Instrument, testing protocol,or Laboratory Reagent becomes available for... READ MORE

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