<p>Large language models identify causal genes in complex trait GWAS</p>

Suyash Shringarpure; Wei Wang; Sotiris Karagounis; Xin Wang; Anna Reisetter; Adam Auton; Aly Khan

doi:10.7490/f1000research.1120394.1

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Shringarpure S, Wang W, Karagounis S et al. Large language models identify causal genes in complex trait GWAS [version 1; not peer reviewed]. F1000Research 2025, 14:1259 (poster) (https://doi.org/10.7490/f1000research.1120394.1)

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Large language models identify causal genes in complex trait GWAS

Suyash Shringarpure¹, Wei Wang, Sotiris Karagounis, Xin Wang, Anna Reisetter, Adam Auton, Aly Khan²

Published 16 Nov 2025 (https://doi.org/10.7490/f1000research.1120394.1)

Author Affiliations

¹ 23andMe Inc, USA
² The University of Chicago, Chicago, Illinois, USA

Copyright © 2025 Shringarpure S et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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CITE

Published 16 Nov 2025

Large language models identify causal genes in complex trait GWAS
[version 1; not peer reviewed]

Suyash Shringarpure¹, Wei Wang, Sotiris Karagounis, Xin Wang, Anna Reisetter, Adam Auton, Aly Khan²

Author Affiliations

¹ 23andMe Inc, USA
² The University of Chicago, Chicago, Illinois, USA

Abstract

Competing Interests

S.S., W.W., S.K., X.W., A.R., A.A., A.K., are employed by or hold stock or stock options in 23andMe, Inc.

Keywords

Large Language Models, GWAS, Causal Gene Identification, Gene Prioritization

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