https://doi.org/10.7490/f1000research.1111304.1
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Sharma P. BIG DATA genetic code [version 1; not peer reviewed]. F1000Research 2016, 5:171 (slides) (https://doi.org/10.7490/f1000research.1111304.1)
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BIG DATA genetic code

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Published 14 Feb 2016

BIG DATA genetic code

[version 1; not peer reviewed]

Author Affiliations
1 Nencki Institute of Experimental Biology, Poland
Abstract
Competing Interests

No competing interests were disclosed

Keywords
Bioinformatics, computational biology, data analysis, sequence analysis, blast, big data, data science, gene, DNA, RNA, protein, central dogma
Comments
15 Comments
Praharshit Sharma
COMPUTATIONAL BIOLOGY, Indraprastha Institute of Information Technology Delhi, New Delhi, India
30 Nov 2023
Stirling's Approximation explains Limiting Value to Napier Constant attained by Praharshit Sharma's HyperProteoGenomic Equation

cf./ Please refer to DOI-indexed Self-Citation provided below:-


Cite as
Praharshit Sharma. (2023). Stirling's Approximation explains Limiting Value to Napier Constant attained by Praharshit... READ MORE
Praharshit Sharma
Department of Computational Biology, Indraprastha Institute of Information Technology Delhi, New Delhi, India
30 Nov 2023
Ensurance of NEPIT-CODOME dimensionality of the Universal Genetic Code by means of adjusting Arbitrary P-norm of CDS or, (C)CDS: (Consensus)-Coding Sequences Mononucleotide Background Frequencies, in Context of its Elementary CA-Model, Computationally Equivalent to QCA: Quaternary Cellular Automata, by Ascertaining CCL... READ MORE
BIOINFORMATICS Sharma
Jaipur National University, Rajasthan, India
26 Jan 2023
It is striking to note that the Sub-rules of ECA: Elementary Cellular Automata namely,

{ 000 , 001 , 010 , 011 , 100 , 101 , 110 , 111 } form the 8 three-Dimensional vertices of a Cube with Unit... READ MORE
Praharshit Sharma
Nencki Institute of Experimental Biology, Poland
09 Jul 2021
Triplet-Codon Block Entropy = e invokes Human-Yeast Co-Evolutionary Relationship .
By the Logical flow of Links, https://bit.ly/homoyeast And https://bit.ly/GCgenHsRnaSc And https://youtu.be/B3dVuP0Kzg0 And https://bit.ly/gc1gc2gc3e we Obtain "Modulus" of First Set of 2 Complex Number solutions to "x" in 4th Link above... READ MORE
Praharshit Sharma
Nencki Institute of Experimental Biology, Poland
02 Feb 2021
Is NAPIER's constant the "CC=Channel Capacity" of Big Data Genetic Code (BDGC)?
We define in the context of Differential-state Cellular Automaton mapping, CC=Channel Capacity as that Proportionality constant for which ratio of Radii/Neighborhood tends to ONE.
https://en.wikipedia.org/wiki/Channel_capacity
For instance, solving... READ MORE
Praharshit Sharma
Nencki Institute of Experimental Biology, Poland
23 May 2020
SARS-nCoV-2 DNA-motifs/PROSITE patterns correlated to SHANNON-FANO Encoding OF First Decimal Approximation TO NEPIT Optimalised GENETIC CODING 

Background:
A 1981 PMID: 7280057 paper authored by 3 Polish Airforce Scientists, rigorously proved using Differential Calculus that the Universal Genetic Code is Nepit/ NAT-encoded, that... READ MORE
Praharshit Sharma
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07 May 2019
A perfect QEMS/Quantum Electro Mechanical System that could simulate Minimal Hardware required to NEPIT/NAT encode the Genetic Code, as per Arguments put forth in 1981 Jerzy Zbigniew Achimowicz et al's Seminal Work potentially Revolves around CosmoQuantum correlations in CMBR regime,... READ MORE
Praharshit Sharma
$comment.userAffiliation.renderToString()
07 May 2019
Relevance Of Author's Big Data Genetic Coding conceptualization to 1981 Polish Airforce work establishing NEPIT/ NAT genetic coding using Differential Calculus, while Studying High Temperature Superconductivity in DNA, and Biological Effects of Microwave Irradiation on Resonance in Chromosomal Abberations, and... READ MORE
Praharshit Sharma
$comment.userAffiliation.renderToString()
07 Jan 2019
Implications of HPG-equation on CRISPR/ Cas9-precision in Genome-editing, computational Aspects of Wobble base-pairing based on Molecular Information Theory, and Fibonacci Numbers via Binomial Coefficients/ Golden ratio in CRISPR

Recent computational understanding of the CRISPR/ Cas9 code (December 2018), in so far... READ MORE
Praharshit Sharma
$comment.userAffiliation.renderToString()
11 Jun 2018
Both the related presentations by the Speaker, namely, on BDGC: Big Data Genetic Code (Sharma.P, 2016) presented at Nencki Institute of Experimental Biology (Warsaw, Poland) and HPG: HyperProteoGenome (Sharma.P, 2016) presented at an ELIXIR conference (Odense, Denmark)
http://elixir-node.cbs.dtu.dk/wp-content/uploads/2017/02/DKBiC-2016-Collection-poster-programme-participants.pdf
rely on an infallibly... READ MORE
Praharshit Sharma
$comment.userAffiliation.renderToString()
15 May 2018
The "CODOME" codes for 100% Universal Proteome.

In a previous Comment, it was inferred that data compression achieved for a 'p'-Base 'n'-Tuple is= (p*n)/(n*(p^n)) = p^(1-n).

Therefore, invoking the RHS/ Right-Hand-Side of the HPG/ Hyper-Proteo-Genomic equation [ 4^(4^x) = 20^(20^1) ] we... READ MORE
Praharshit Sharma
$comment.userAffiliation.renderToString()
04 Apr 2018
As per the LANDER/ WATERMAN Model to deduce “Probability of Base NOT Sequenced” based on the estimated sequence-coverage, does the RHS of “Reciprocal”-HyperProteoGenomic equation correlate with “Optimal Coverage” for TUMOR-Samples?

PRIMARY WEB REFERENCE-
“For optimum results Illumina recommends a minimum coverage of... READ MORE
Praharshit Sharma
$comment.userAffiliation.renderToString()
30 Mar 2017
ECA: Elementary Cellular Automata 256 rules suffice to describe BDGC: Big Data Genetic Code, so do "Nepit"-scaled e-mer 4-nt Logic/ '2-bit' (Crumb) codon. And a Clue towards "3-Parallel Processors MODEL" of 8-Histone Octamers in Chromatin.

Observing that, Data Compression fraction achieved... READ MORE
Praharshit Sharma
$comment.userAffiliation.renderToString()
13 Mar 2017
The HyperProteoGenomic equation confirms fraction of trait/disease-associated SNPs in GWAS-meta-Analysis

Background: My single-authored "Big Data Genetic Code", presented at Polish Academy of Sciences: Nencki Institute of Experimental Biology (http://dx.doi.org/10.7490/f1000research.1111304.1) and subsequently followed up as the "HyperProteoGenome" at ELIXIR 2nd Annual Danish... READ MORE
Praharshit Sharma
$comment.userAffiliation.renderToString()
12 Apr 2016
One Question that might arise is: How "BIG" is this "BIG-DATA Genetic Code" ?

From slide 9 [07/17], substituting for the value of 'c' computed,
LHS = 4^(4^c) = 4^(4^2.7168...) = RHS = 20^20 ~ 1.048576 × 10^26
(which is strikingly of the... READ MORE
 
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