Endovascular management of aortic aneurysm with severe neck angulation and/or iliac artery tortuosity using multiple stiff wire technique: a case series

Introduction

The endovascular aortic repair (EVAR) technique has been developed for over 30 years since the first report by Parodi, et al.¹ and recommended over open surgical repair by 2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease² in descending thoracic aortic aneurysm (TAA), ruptured descending TAA, abdominal aortic aneurysm (AAA), and ruptured AAA. A suitable aortic neck is one of the essential components for EVAR and hostile neck anatomy has been related to early graft failure and long-term adverse events.³ Stent graft collapse, stent graft migration, type I endoleak, and late aneurysm rupture appear to be linked with severe neck angulation.⁴

Nowadays, advanced techniques were developed to adjust and compromise the aneurysm neck angulation such as kilt technique which involves aortic-cuff stent-graft implantation before aortic main-body stent-graft implantation, and endostapling technique to reinforce device seal and fixation.^5,6 But, those techniques add additional devices and complexity to the procedure. We proposed a simple technique to modify severe neck angulation and/or iliac artery tortuosity by using the multiple stiff wire (MSW) technique with reports of application in six patients.

Methods

Two femoral accesses were required for the MSW technique. Then, a guidewire with a support catheter was inserted through the right and left femoral arteries and positioned in the abdominal or thoracic aorta. Wire exchanges were done with 0.035″ × 260 cm Lunderquist Extra Stiff Wire (Cook Aortic Interventions, Bloomington, USA) in both femoral accesses. It can be considered to add multiple stiff wires to align the torturous neck/iliac artery. Delivery of the stent graft main body can be done via one of the accesses. After the main body deployment, the contralateral extra stiff wire can be withdrawn from the access then contralateral limb extension cannulation and deployment can be done as required.

Case presentation

Case 1

An 83-year-old woman was presented to the emergency department with abdominal pain that radiate into both lower limbs in the last hour. The patient had a history of hypertension and dyslipidemia. CT-Scan Angiography (CTA) revealed an abdominal aorta aneurysm from the inferior of superior mesentric artery until aortic bifurcation with length of 10.8 cm and maximum sac diameter of 7.4 cm and fusiform aneurysm of bilateral common iliac artery (CIA) with right diameter of 1.1 cm and left diameter of 1.5 cm. Infrarenal neck length is 22 mm with angulation of 85° (Figure 1A). The patient then prepared for EVAR procedure.

Figure 1. Endovacular aortic repair with multiple stiff wire technique of the 1^st patient.

A. Preoperative volume rendering computed tomography angiography (CTA); B. Initial aortography; C. Aortography showed reduction of the proximal neck angulation after insertion of the second stiff wire; D. Stent graft main body deployment; E. Final aortography; F. Follow up volume rendering CTA after three months.

The EVAR procedure was done with right and left femoral access that was gained with surgical cutdown technique. Initial aortography revealed a fusiform aneurysm at infrarenal abdominal aorta with short and tortuous neck (Figure 1B). The MSW technique with two stiff wires was done to align the tortuous proximal neck (Figure 1C). An Endurant II ETBF 23 mm × 13 mm × 145 mm stent graft main body (Medtronic, Santa Rosa, CA, USA) was deployed via right femoral artery (RFA) access (Figure 1D). The extra stiff wire from left femoral artery (LFA) was withdrawn and canulation for contralateral limb extension with guide wire was done. An Endurant II ETLW 16 mm × 13 mm × 93 mm stent graft extension (Medtronic, Santa Rosa, CA, USA) was inserted and deployed overlapped with the main body from the neo bifurcation to the left CIA. The right Endurant II ETLW stent graft extension sized 16 mm × 13 mm × 93 mm (Medtronic, Santa Rosa, CA, USA) was deployed from the right femoral artery overlapped with the main body. Evaluation aortography revealed type IA endoleak and left CIA wasn’t filled completely. A stent graft balloon catheter was inserted from the LFA and few intrastent post dilatation was done at infrarenal abdominal aorta and proximal of the CIA. Another evaluation aortography was done and eventually, there still was type IA endoleak. It was decided to add another Endurant II ETCF 25 mm × 25 mm × 49 mm stent graft extension (Medtronic, Santa Rosa, CA, USA) proximal from the main body. Final aortography revealed a good position of the stent grafts, both renal and iliac arteries were filled with contrast, and no sign of endoleak was found (Figure 1E).

The patient was discharged without any complaints. The follow-up CTA after 3 months revealed stent expansion of 19.3 mm at infrarenal aorta (maximum diameter was 60.2 mm), good stent position without stent migration and no endoleak was found (Figure 1F).

Case 2

A 55-year-old man presented to our hospital with stomach fullness and back pain in the past 2 weeks. The patient had a stomach massage before, but it didn’t relieve his symptoms. The patient denied history of hypertension and diabetes, but he was a smoker. CTA revealed a contained rupture of abdominal aortic aneurysm with intraluminal thrombus with a length of 10.32 cm and maximum sac diameter of 10.1 cm (maximum vascular diameter filled with contrast was 6.49 cm), Infrarenal neck length is 18.9 mm with angulation of 70.2° (Figure 2A). The patient then prepared for EVAR procedure.

Figure 2. Endovacular aortic repair with multiple stiff wire technique of the 2^nd patient.

A. Preoperative volume rendering computed tomography angiography (CTA); B. Initial aortography with two stiff wire showed straightening of the proximal neck angulation; C. Stent graft main body deployment; D. Final aortography; E. Follow up volume rendering CTA after three months.

The EVAR procedure was done with puncture from right and left femoral access. The MSW technique was applied to this patient. Initial aortography revealed a contained rupture of aortic aneurysm at infrarenal abdominal aorta with enough length but tortuous neck (Figure 2B). A SEAL Bifurcated Stent Graft sized 28 × 50 mm (S&G Biotech, Yongin, Korea) main body was deployed via RFA (Figure 2C). The extra stiff wire from LFA was withdrawn and canulation for contralateral limb extension was done. SEAL Bifurcated Stent Graft extension 12(16) × 120 mm (S&G Biotech, Yongin, Korea) was inserted from left femoral artery access and deployed until the distal part was right above left internal iliac artery. The right stent graft extension with SEAL Bifurcated Stent Graft extension 12(16) × 120 mm (S&G Biotech, Yongin, Korea) was inserted from the RFA and deployed until the distal part was right above right internal iliac artery. Evaluation aortography revealed that contras filled the whole cover stent without endoleak, but the distal part of the right limb extension didn’t expand perfectly. After several post-dilatation was done with Reliant Stent Graft Balloon (Medtronic, Santa Rosa, CA, USA), the right limb extension expanded perfectly (Figure 2D). The EVAR procedure was done without any complications.

The patient was discharged without any complaints. Follow-up CTA after three months revealed stent expansion of 33.5 mm at infrarenal aorta (maximum diameter with thrombus was 69 mm), no stent migration, and no endoleak was found (Figure 2E).

Case 3

A 69-year-old man presented to our hospital with stomach fullness accompanied by nausea and vomiting in the last three months. The patient also had a complaint of a palpable non-pain lump in his stomach. He denied history of hypertension or diabetes, but he was an ex-smoker. There was a palpable pulsatile mass in the abdominal region. CTA revealed dissection of abdominal aorta aneurysm with a length of 6.99 cm and maximum sac diameter of 5.95 cm (maximum vascular diameter filled with contrast was 3.89 cm), infrarenal neck length is 5.00 mm with angulation of 75.4° (Figure 3A). The patient then prepared for EVAR procedure.

Figure 3. Endovacular aortic repair with multiple stiff wire technique of the 3^rd patient.

A. Preoperative volume rendering computed tomography angiography (CTA); B. Initial aortography with two stiff wire showed straightening of the proximal neck angulation; C. Stent graft main body deployment; D. Final aortography.

The EVAR procedure was done with puncture from right and left femoral access. The MSW technique was applied to this patient. Initial aortography revealed an aortic aneurysm at infrarenal abdominal aorta until bilateral CIA with enough length but tortuous neck (Figure 3B). SEAL Bifurcated Stent Graft 24 × 50 mm main body (S&G Biotech, Yongin, Korea) was deployed via RFA (Figure 3C). The extra stiff wire from LFA was withdrawn and canulation for contralateral limb extension was done. SEAL NOVUS Flared Limb Stent Graft extension 12(20) × 120 mm (S&G Biotech, Yongin, Korea) was inserted from LFA access and deployed until the distal part was right above left internal iliac artery. The right stent graft extension with SEAL NOVUS Flared Limb Stent Graft extension 12(20) × 100 mm (S&G Biotech, Yongin, Korea) was inserted from the RFA and deployed until the distal part was right above right internal iliac artery. Post-dilatation was done with balloon catheter in left CIA. Evaluation aortography revealed that contras filled the whole cover stent without endoleak (Figure 3D). The EVAR procedure was done without any complications.

The patient was discharged without any complaint. Unfortunately, the patient declined the evaluation CTA because of patient’s malignancy related condition that was diagnosed after the EVAR procedure, but he didn’t have any complaint related to the aortic or vascular disease after 3 months follow-up.

Case 4

A 71-year-old man was referred to our outpatient clinic with a pulsatile mass in lower left abdomen. The patient had a stable condition. CTA revealed impending rupture of fusiform abdominal aorta aneurysm with a length of 9.11 cm and maximum sac diameter of 6.3 cm (maximum vascular diameter filled with contrast was 3.63 cm), infrarenal neck length is 2.27 mm with angulation of 50°. The access site was tortuous and heavily calcified (Figure 4A). The patient was prepared for elective EVAR and percutaneous transluminal angioplasty.

Figure 4. Endovacular aortic repair with multiple stiff wire technique of the 4^th patient.

A. Preoperative volume rendering computed tomography angiography (CTA); B. Initial aortography; C. After stent impalntation, arteriography revealed stenosis at left CIA; D. Iliac stent graft deployment; E. Final aortography; F. Follow up volume rendering CTA after three months.

The EVAR procedure was done with right and left femoral access that was gained with surgical cutdown technique. Initial aortography revealed a fusiform aneurysm at infrarenal abdominal aorta with stenosis at both CIAs (Figure 4B). Several plain balloon dilatations were done at both CIAs to facilitate the delivery of the stent graft main body. SEAL Novus stent graft main body sized 24 mm × 50 mm (S&G Biotech, Yongin, Korea) were deployed with SEAL bifurcated stent graft extension 12(18) × 100 mm (S&G Biotech, Yongin, Korea) until left CIA and SEAL bifurcated stent graft extension 12(16) × 100 mm (S&G Biotech, Yongin, Korea) until right CIA. Arteriography revealed there was still stenosis at left CIA (Figure 4C). It was decided to add another stent at left CIA, but there was dificulty to pass the lesion. MSW technique was used to align the left CIA using Radiofocus Extra Stiff Wire 0.035″ × 260 mm (Terumo, Somerset, NJ). Dynamic 10 × 56 mm stent graft (Biotronik, Berlin, Germany) was implanted at left CIA (Figure 4D). Final aortography revealed a good position of the stent-grafts, both renal arteries and iliac arteries were filled with contrast, and no sign of endoleak was found (Figure 4E).

The patient was discharged without any complaint. Follow-up CTA after 3 months revealed stent expansion of 23.0 mm at suprarenal aorta, 30.8 mm at infrarenal aorta (maximum diameter with thrombus was 59.1 mm), 28.8 mm at aortic bifurcation, 9.3 mm at right CIA, and 9.9 mm at left CIA, no stent migration, and no endoleak was found (Figure 4F).

Case 5

A 63-year-old man presented to our hospital with tearing chest pain that radiate to his back in the past 3 days. The patient had a history of hypertension and he was a smoker. CTA revealed an aortic aneurysm with extensive mural thrombus with aorta descendent’s maximum diameter of 53.5 mm, thoracoabdominal aorta maximum diameter of 92.5 mm, suprarenal aorta maximum diameter of 98.1 mm, infrarenal aorta maximum diameter of 51.8 mm, with angulation of 70.2°, and suspected rupture at peritoneal and thorax cavity (Figure 5A). The patient was than prepared for thoracic endovascular aortic repair (TEVAR) procedure.

Figure 5. Thoracic endovacular aortic repair with multiple stiff wire technique of the 5^th patient.

A. Preoperative volume rendering computed tomography angiography (CTA); B. Initial aortography with two stiff wires; C. Additional stiff wire was added to straighten the angulation; D. Stent graft deployment; E. Final aortography; F. Follow up volume rendering CTA after three months.

The TEVAR procedure was done with puncture from right and left femoral access. The MSW technique was applied to this patient. Initial aortography revealed an aortic aneurysm at descending thoracic aorta until abdominal aorta (Figure 5B). Additional stiff wire was added with a total of three stiff wires used to straighten the aorta (Figure 5C). SEAL Thoracic Stent Graft 36 × 200 mm (S&G Biotech, Yongin, Korea) was deployed at descending thoracic aorta (Figure 5D). Evaluation aortography revealed good stent position but there was type IV endoleak. Observation for 10 minutes was done, and another evaluation aortography revealed no more endoleak (Figure 5E). The TEVAR procedure was done without any complications.

The patient was discharged without any complaint. Follow-up CTA after 3 months revealed stent expansion of 18.2 mm at aorta descendent (maximum diameter with thrombus was 56 mm), stent expansion of 29.4 mm at thoracoabdominal aorta (maximum diameter with thrombus was 88.2 mm), no stent migration, and no endoleak was found (Figure 5F).

Case 6

A 45-year-old man presented to our hospital with lower abdominal pain radiating to epigastric in the past 3 months that getting worse in the past 3 days. The patient had undergone TEVAR with indication of Stanford A acute aortic dissection 2 years earlier. CTA revealed an impending rupture of pseudoaneurysm sized ±7 × 12 cm with leakage from the distal part of the previous TEVAR stent with 85.9° angulation of the aorta, distal from the previous stent (Figure 6A). The patient was then prepared for an extension TEVAR procedure.

Figure 6. Thoracic endovacular aortic repair with multiple stiff wire technique of the 6^th patient.

A. Preoperative volume rendering computed tomography angiography (CTA); B. Initial aortography; C. Two stiff wire was added to straighten the angulation; D. Stent graft deployment; E. Final aortography; F. Follow up volume rendering CTA after three months.

The procedure was done with puncture from right brachial, right and left femoral access. Initial aortography revealed dissection of the descending thoracic aorta with an entry tear from the distal of the previous TEVAR stent (Figure 6B). Wire snaring was done from the right brachial artery to the right femoral artery. Wire exchange was done with the 0.035″ × 300 cm Lunderquist Extra Stiff Wire (Cook Aortic Interventions, Bloomington, USA) and additional extra stiff wire was inserted from the left femoral artery (Figure 6C). SEAL Thoracic Stent Graft 36(32) × 130 mm (S&G Biotech, Yongin, Korea) was deployed at descending thoracic aorta until abdominal aorta, overlapped with the previous stent (Figure 6D). Evaluation aortography revealed good stent position without any endoleak (Figure 6E). The TEVAR procedure was done without any complications.

The patient was discharged without any complaint. Follow-up CTA after 3 months revealed stent expansion of 30.8 mm at aorta descendent (maximum diameter with thrombus was 98.7 mm), stent expansion of 33.9 mm at thoracoabdominal aorta (maximum diameter with thrombus was 114.3 mm), no stent migration, and no endoleak was found. There was an abdominal aortic aneurysm sized 47.33 mm at supra renal and 43.5 mm at infrarenal (Figure 6F). The patient didn’t have any complaints.

Discussion

EVAR with severe neck angulation was associated with a significantly higher rate of type 1a endoleak until 2 years, neck-related secondary procedure until 3 years, migration rates until 1 year, aneurysm-related and all-cause mortality until 1 year, but not related to aneurysm sac increase and rupture.⁷ High-tortuosity neck in TEVAR also has its problem related to a significantly higher proportion of endoleaks, a potential risk factor for proximal stent-graft collapse or infolding, renal failure, stroke, longer operation time, and lower survival rate.^8,9

Data from the ANCHOR trial showed that the use of Aptus Heli-FX EndoAnchor System (Medtronic, Santa Rosa, CA, USA) was associated with higher but not significant 2 years rate of freedom from type Ia endoleak, neck dilation, and sac enlargement compared to the control group.¹⁰ The Kilt technique appeared to significantly straighten neck angle without leaving additional death or re-intervention during 22 ± 15 months follow up and no newly developed endoleaks during 15.9 ± 16.4 months follow up.¹¹ Although those techniques showed a good result to overcome the angulation of the aortic neck, they add additional complexity to the procedure, specialized devices, need special training for the operator, and also greater cost of the procedure. Several proposed simple novel techniques such as directional tip control technique, push-up technique, and using a large bore sheath to untwist tortuous iliac arteries seem promising but need further investigation.^4,12,13

Our MSW technique provides a simple solution to manage neck/artery angulation. It can be used in the thoracic aorta, thoracoabdominal aorta, abdominal aorta, or iliac artery. Our experience applying the technique in six different scenarios showed satisfactory results. There is no type I endoleak, stent migration, or enlargement of the aneurysm size found after follow-up CTA in all but one of our patients. The determination of how many stiff wires would be used in the procedure is based on operator judgment until the tortuosity of the vessel were straighten enough to facilitate stent graft deployment. It is important to always cover the stiff wire with a catheter, so the stiff wire didn’t contact directly with the vessel and the risk of dissection was reduced. We also recommend oversizing 20% of the main body stent graft to create an optimal seal between the stent graft and the aortic wall.

Further studies will be made for the MSW technique with a larger population and study design. Clear indications should be made with the straightening degree calculation of the technique.

Conclusion

MSW technique is a simple and effective technique to modify aortic neck/artery angulation in TEVAR or EVAR procedure.

Consent

Written informed consent has been obtained from the patients for publication of the case and accompanying images.