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Case Report
Revised

Case Report: Solid pseudo-papillary tumor of the pancreas

[version 2; peer review: 1 approved]
PUBLISHED 02 Jul 2024
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OPEN PEER REVIEW
REVIEWER STATUS

Abstract

Solid pseudo-papillary tumors (SPT) of the pancreas are rare neoplasms accounting for less than 2% of all pancreatic tumors and primarily affecting young women. They are generally characterized by a clinical and radiological polymorphism. In most cases, complete surgical resection is curative. We report a case of a young woman presenting with a pancreatic tumor revealed through a vague non-specific abdominal pain. The diagnosis was based on the histological examination of the surgically-removed piece.

Keywords

Pancreas, Tumor, surgery, Solid pseudopapillary neoplasm of the pancreas

Revised Amendments from Version 1

We have modified the paper to consider the reviewer’s comments. We have clarified the utility of endoscopic ultrasound (EUS). EUS-guided fine needle aspiration (EUS-FNA) and biopsy in the diagnosis of solid pseudopapillary pancreatic tumors and further detailed surgical techniques.

See the authors' detailed response to the review by Javier Cienfuegos

Introduction

A solid pseudo-papillary tumor (SPT) of the pancreas is a rare pathological entity accounting for approximately 2% of pancreatic exocrine tumors.1,2

Its pathogenesis is still discussed. Clinical symptomatology is not specific and the discovery may be fortuitous. The diagnosis of this tumor is histological. The treatment is exclusively surgical associated with a good prognosis.3,4

Observation

A 19-year-old African woman, a high school student with no history of abdominal trauma, surgery or smoking was hospitalized for the exploration of an abdominal pain in the epigastrium and the left hypochondrium. She also had no specific family medical history. The pain started six months before admission and gradually got worse. It was associated with an alteration of her general state. She reported 11kg weight loss during this period.

The physical examination was uneventful except for a tenderness at the level of the epigastrium. Laboratory findings were normal. The abdominal Doppler ultrasound showed a round, well limited solid vascular mass. It was actually a large one measuring 42 mm and extending from the retroperitoneum down to the lower pole of the homolateral kidney. It was hyperechogenic and heterogeneous in appearance but mostly cystic in nature. A computed tomography (CT) Scan of the abdomen and the pelvis together with a pancreatic MRI revealed the presence of a 44×42×34 mm solid mass in the pancreatic tail. This mass was spontaneously isodense with a moderate and heterogeneous contrast enhancement and some scattered cysts. This mass presented regular contours with a predominantly lower extension reaching the descending colon without any symptoms of compression. The peritoneal fat was of normal appearance (Figure 1). The biological, hepatic and pancreatic check-up was normal. EUS-guided biopsy is not available in our hospital service, That’s why our patient underwent operation without a precise diagnosis before intervention. The surgical operation confirmed the existence of a large exophytic tumor (diameter: 5cm) appended to the lower edge of the pancreatic tail. There was no locoregional invasion or distant metastasis. Surgical resection of the tumor by partially cutting the pancreas was performed. The surgery was without complication. The histological examination revealed a solid pseudopapillary tumor of the pancreas. Indeed, the cyto-architectural aspects confirmed our diagnosis. An immuno-histochemical study showed the existence of CD10 tumor cells. The patient developed well in the postoperative period, with normal US (three, 12 and 24 and 48 months) and CT scans (12, 24 and 48 months) and no evidence of residual disease.

e9081bb8-a4ad-4826-b74e-ca7ad0443e5d_figure1.gif

Figure 1. Abdominal magnetic resonance imaging showing a heterogeneous mass repulsing below the left kidney.

Discussion

Solid pseudo-papillary tumor (SPT) of the pancreas is a rare pathological entity first described by V. K. Frantz in 1959.5 This entity represents 0.7 to 2.7 % of all the exocrine pancreatic tumors and less than 5 % of cystic pancreatic tumors.5 The rarity of this neoplasm makes our case particular.

Less than 1000 cases have been reported in the literature, mostly in isolated cases. It is classically described in young females in more than 95% of cases with an average age of 22 years (from 2 to 85 years)6 as was the case of our patient. Rare cases in males and the elderly have also been reported.7 It was also frequently found in different ethnic groups such as Black and Asian people. Its etiopathogenesis is still unknown. Two diagnostic hypotheses were proposed. The first was based on the role of sex hormones due to the female predominance and the presence of progesterone receptors. The second was more directed towards an embryonic origin with a totipotent stem cell that would be transformed into an exocrine and endocrine pancreatic cell.8

The tumors were discovered in different circumstances. The revelation pattern was vague abdominal pain in 58% of cases. The discovery may be fortuitous on abdominal imaging performed for another reason. It may also be discovered incidentally on a routine examination.

The tumor can also be revealed as an abdominal mass or as a complication which can occur in the form of a compression of the digestive, biliary or vascular structures when the tumor becomes voluminous or in the case of an intra-tumor hemorrhage. These complications may be spontaneous or secondary to abdominal trauma (3%).6,9

In our case, it was the abdominal pain which prompted the need for a follow-up imaging examination. There were no specific biological signs.

These tumors affect the head, body and tail of the pancreas, but develop preferably in the body and tail region (64% of cases).5,10 Rare cases of extra-pancreatic localizations (retroperitoneum, retro duodenal, meso-colic and hepatic) have been described. These rare extra-pancreatic areas are suggestive of two etiopathogenic hypotheses: a development from ectopic pancreatic tissue, or a development from totipotent stem cells being transformed into pancreatic cells. Macroscopically, the tumor is often voluminous, 10 cm long on average. It can reach 25 cm in diameter. It is often rounded or oval, surrounded by a fibrous capsule.1,11

On microscopy, the solid zones are composed of tumor cells of small size, monomorphic, cuboid or polygonal. A clear cytoplasm that is sometimes vacuolated and that contains diastase-resistant PAS-positive (periodic acid Schiff) globules can be seen. The nucleus is oval, regular, with peripheral chromatin condensations. The cells are arranged either as solid plaques or as a pseudo-papillary device with a fibrovascular axis bordered by a row of cells. Mitoses and cytotoxic atypia are an uncommon occurrence. Foamy histiocytes and giant cells can be found around cholesterol clefts.11

The stroma is usually of the endocrine type. It is rich in blood capillaries. The anatomo-pathological criteria for malignancy are found in only 10 to 15% of cases (invasion of adjacent structures, arterial embolism, perineural invasion, and lymph node metastases that are regional or distant). In these cases, the SPTP is classified as solid pseudo-papillary carcinoma. SPTP immunohistochemical profile is variable. Typically, tumor cells are labeled with anti-CD10, alpha-1 antitrypsin, vimentin, NSE, E-caderin and beta-catenin antibodies. Anti-progesterone antibody labeling is also noted. The positive immuno-labeling of tumor cells for some endocrine markers may prove some endocrine differentiation.

Morphological explorations make it possible to study the characteristics of the lesion: its nature (solid, cystic or mixed), to specify the organ of origin, to study its features regarding the neighboring vessels and the organs and to look for metastases at distances.

Local invasion is reported in 15% of cases. Secondary sites were reported in 5% of the cases mainly affecting the liver.12

An abdominal ultrasound shows an echogenic and homogeneous mass, or heterogeneous with both cystic and solid zones.

An abdominal computed tomography (CT) shows a limited heterogeneous lesion that is rather hypodense. It is not very vascularized. It is also of mixed composition associating solid and cystic zones and is little or partially enhanced at the periphery after injection of the contrast agent. Signs of compression of the adjacent organs can be observed. The magnetic resonance imaging (MRI) shows a heterogeneous lesion with a hyper signal in T1 and T2. The capsule is often visible in the form of a hypo-intense border in T1.13,14

An unequivocal diagnosis remains histological. Endoscopic techniques offer ways to diagnose pseudopapillary solid tumor of pancreas(SPTP) before surgery. Like abdominal ultrasound, SPTP can appear as solid, cystic, or a combination of both on endoscopic ultrasound (EUS). EUS-guided fine needle aspiration (EUS-FNA) is now commonly used to diagnose pancreatic tumors, with high accuracy rates of over 80%. This technique not only allows for biopsy but also enables the minimally invasive collection of fluid samples, such as pancreatic juice and cyst fluid.5

Regarding surgical technique, indeed Parenchyma-preserving pancreatectomies, such as enucleation, central pancreatectomy, and duodenum-preserving pancreatic head resection (DPPHR), are being performed more frequently.15

Studies have shown that these procedures can lower the occurrence of pancreatic endocrine and exocrine insufficiencies while maintaining positive short- and long-term results.15

The choice of the operating method depends on the tumor size, localization and the possible invasion of adjacent organs.

Enucleation, duodenum-preserving pancreatic head resection (DPPHR), and pancreaticoduodenectomy are options for SPTP located in the pancreatic head.16

Enucleation, central pancreatectomy, and distal pancreatectomy (with or without splenectomy) are available for tumors in the pancreatic body and tail.17,18

Minimally invasive techniques, including laparoscopic and robotic surgery, can be suded in both traditional and parenchyma-preserving procedures.

To date, no consensus on the best approach for the treatment of SPTP metastasis has been established. Metastasis to lymph nodes is not common, occurring in only 1.0% to 7.9% of cases. Therefore, extended lymphadenectomy may not be needed for most patients.18

The excision should be extended in case of invasion of the neighboring organs and possible nodules of peritoneal carcinosis which must be resected. The presence of invasion of the portal or mesenteric veins should not contraindicate a curative treatment, as cases of portal or mesenteric resection have been reported with prolonged survival. Associated metastatic lesions should be resected with a reasonable risk, and tumor recurrences should benefit from a surgical excision.

Adjuvant therapy chemotherapy and radiotherapy has been shown to be effective. in some unresectable cases.12,13

The prognosis is good even in cases of metastasis.5 Survival, up to 17 years, has been reported for metastatic tumors. Long-term survival after complete resection of a non-metastatic tumor is between 80 and 90%, but associated with a recurrence rate of 10 to 15%.9 No pathological criteria (vascular, perineural and ganglionic invasion or mitotic index) currently predict survival.

Conclusions

SPTP is a rare tumor with attenuated malignancy. Its diagnosis is based on histology coupled with immune-histochemistry. Surgery remains the treatment of choice even in the presence of metastases.

Patient consent

We obtained written informed consent from the patient for the use and publication of their data.

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Version 2
VERSION 2 PUBLISHED 16 Oct 2023
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Ghanney O, Saad R, Ben A mor s and Mayada T. Case Report: Solid pseudo-papillary tumor of the pancreas [version 2; peer review: 1 approved]. F1000Research 2024, 12:1331 (https://doi.org/10.12688/f1000research.140561.2)
NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article.
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ApprovedThe paper is scientifically sound in its current form and only minor, if any, improvements are suggested
Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit.
Not approvedFundamental flaws in the paper seriously undermine the findings and conclusions
Version 2
VERSION 2
PUBLISHED 02 Jul 2024
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Reviewer Report 03 Jul 2024
Javier Cienfuegos, Clínica Universidad de Navarra, Pamplona, Navarra, Spain 
Approved
VIEWS 7
The authors have made corrections and improved the manuscript.  The paper ... Continue reading
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Cienfuegos J. Reviewer Report For: Case Report: Solid pseudo-papillary tumor of the pancreas [version 2; peer review: 1 approved]. F1000Research 2024, 12:1331 (https://doi.org/10.5256/f1000research.168423.r298016)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
Version 1
VERSION 1
PUBLISHED 16 Oct 2023
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Reviewer Report 10 Jun 2024
Javier Cienfuegos, Clínica Universidad de Navarra, Pamplona, Navarra, Spain 
Not Approved
VIEWS 9
1.- The differential diagnosis of cystic lesions of the pancreas is a challenge given that in many cases they are discovered incidentally and due to the heterogeneity they display.

The authors present the case of a solid ... Continue reading
CITE
CITE
HOW TO CITE THIS REPORT
Cienfuegos J. Reviewer Report For: Case Report: Solid pseudo-papillary tumor of the pancreas [version 2; peer review: 1 approved]. F1000Research 2024, 12:1331 (https://doi.org/10.5256/f1000research.153929.r280969)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
  • Author Response 14 Jun 2024
    olfa Ghanney, University of Monastir, Monastir, Tunisia
    14 Jun 2024
    Author Response
    Dear Reviewer

    Thank you for taking the time to read our article and for your valuable feedback. Allow me to clarify a few points. Please know that we are ... Continue reading
  • Author Response 02 Jul 2024
    olfa Ghanney, University of Monastir, Monastir, Tunisia
    02 Jul 2024
    Author Response
    Cover Letter
    [Ghannei Olfa]
    [University of Monastir, Monastir, Tunisia]
    [Email: gounayolfa@gmail.com]
    [25 june 2024]

    [Javier Cienfuegos]
    [Clínica Universidad de Navarra, Pamplona, Navarra, Spain] 

    Dear Javier Cienfuegos,
    I hope ... Continue reading
COMMENTS ON THIS REPORT
  • Author Response 14 Jun 2024
    olfa Ghanney, University of Monastir, Monastir, Tunisia
    14 Jun 2024
    Author Response
    Dear Reviewer

    Thank you for taking the time to read our article and for your valuable feedback. Allow me to clarify a few points. Please know that we are ... Continue reading
  • Author Response 02 Jul 2024
    olfa Ghanney, University of Monastir, Monastir, Tunisia
    02 Jul 2024
    Author Response
    Cover Letter
    [Ghannei Olfa]
    [University of Monastir, Monastir, Tunisia]
    [Email: gounayolfa@gmail.com]
    [25 june 2024]

    [Javier Cienfuegos]
    [Clínica Universidad de Navarra, Pamplona, Navarra, Spain] 

    Dear Javier Cienfuegos,
    I hope ... Continue reading

Comments on this article Comments (0)

Version 2
VERSION 2 PUBLISHED 16 Oct 2023
Comment
Alongside their report, reviewers assign a status to the article:
Approved - the paper is scientifically sound in its current form and only minor, if any, improvements are suggested
Approved with reservations - A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit.
Not approved - fundamental flaws in the paper seriously undermine the findings and conclusions
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