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Case Report
Revised

Case Report: Leathery black plaque on the temple and scalp

[version 2; peer review: 2 approved]
PUBLISHED 08 Apr 2024
Author details Author details
OPEN PEER REVIEW
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This article is included in the Datta Meghe Institute of Higher Education and Research collection.

Abstract

Background

Epidermal nevus sebaceous, commonly known as the nevus sebaceous of Jadassohn, is a congenital sebaceous hamartoma. It typically manifests as a single yellowish plaque across the head and neck and is composed of sebaceous glands. It commonly occurs during infancy and grows during puberty. Usually, it follows a benign course; however, in a few cases, it can be malignant. This is the case of a 13-year-old child with verrucous plaques on the temple and scalp.

Case report

We report the case of a 13-year-old boy with a steadily developing hyperpigmented verrucous plaque on the scalp and ipsilateral side of his face. A dermoscopic examination revealed ridges and fissures in a cerebriform pattern with yellowish-gray globules and a papillary appearance. Physical examination and laboratory tests revealed no abnormalities. Biopsies were taken from the scalp and temple area, and the findings were consistent with the diagnosis of nevus sebaceous. The patient was referred to a plastic surgeon for a staged excision.

Conclusions

We describe a unique example of a sebaceous nevus that affected the scalp and ipsilateral side of the face. As this hamartomatous growth carries the risk of cancer development, a dermatologist must identify the condition and begin treatment before malignant transformation occurs. This example of multiple verrucous plaques is an exception.

Keywords

hamartoma, nevus sebaceous, scalp, case report

Revised Amendments from Version 1

We have added the differentiating points between the close differential diagnosis of Nevus Sebaceous, how to clinically identify the malignant transformation in the case of Nevus Sebaceous, and various non-invasive investigations for the same with genetics.

See the authors' detailed response to the review by Aswath Rajan
See the authors' detailed response to the review by Dipanjan Basu

Introduction

Nevus sebaceous (NS), initially described by Jadassohn, is a complicated hamartoma that typically develops on the face or scalp and has an epithelial or adnexal origin.1

It can appear at birth or develop in infancy and increases during puberty, suggesting a hormonal influence. It can occasionally be found in other locations, such as the trunk or the oral or vaginal mucosa, although it mostly affects the scalp. Less frequently, it affects the preauricular area and neck.2

Nevus sebaceous of Jadassohn (NSJ) develops in three stages. It manifests as isolated, well-circumscribed, smooth, yellowish plaques without hair during the infantile period. It becomes more noticeable with a verrucous or mamillated appearance during puberty. The last stage is characterised by peripheral telangiectasias and a nodular or tumoral appearance.3

Many neoplasms develop alongside NS as proliferative growth begins. Both benign and malignant tumors have been reported to grow in NS. NS can be a site of basal cell cancer, syringocystadenoma papilliferum, trichoblastoma, and hidradenoma.4

Case report

A 13-year-old boy visited the dermatology outpatient department on 8th September 2023 with a raised lesion on his scalp since birth and a lesion that had spread to the left side of the face over ten years. The ophthalmological, neurological, or cutaneous systems did not exhibit any abnormalities during physical examination. These skin lesions had not previously occurred in the family. The results of all laboratory tests, including the kidney function test, liver function test, urine examination, and complete blood count were within normal ranges. The patient had no other complaints.

On cutaneous examination, a well-demarcated hyperpigmented verrucous plaque with a size of 8 × 4 cm was present on the frontal area of the scalp extending down to involve the forehead and a 7 × 3 cm plaque was present on the temporoparietal area and left preauricular area [Figure 1]. Based on the patient’s medical history and physical examination, the possible differential diagnoses were identified as congenital melanocytic nevus, giant seborrhoeic keratoses, and verrucous epidermal nevus. However, a thorough examination through dermoscopy and histology conclusively ruled out these possibilities. In seborrheic keratosis, other than ridges and fissures multiple milia and comedone-like openings will be there. In acanthosis nigricans, there will be papillary projections with hyperpigmented dots and perifollicular pigmentation. We confirmed on clinical grounds that there were no clinical signs in the lesion to undergo a malignant transformation like ulceration, bleeding from the lesion or sudden increase in the size of the lesion. On dermoscopic examination, ridges and fissures were present in a cerebriform pattern with yellowish-grey globules and a papillary appearance [Figure 2]. Histopathological examination revealed acanthosis, papillomatosis, and mild hyperkeratosis. There were immature and mature sebaceous glands with sebaceous hyperplasia and primitive hair follicles [Figure 3]. The diagnosis of nevus sebaceous was established based on clinical presentation, dermoscopic findings, and histological analysis. The patient was referred to a plastic surgeon on 8th September 2023 for a staged surgical excision of the nevus sebaceous. Our dermatology department does not offer plastic surgery services, hence the referral. Unfortunately, the patient was lost to follow-up after the referral, and we do not have any further information available.

b3962dd3-627c-438a-a518-6a7f096940f6_figure1.gif

Figure 1. Verrucous plaque on frontal, temporal and preauricular area.

(Written informed consent for publication of their clinical details and clinical images was obtained from the relatives of the patient).

b3962dd3-627c-438a-a518-6a7f096940f6_figure2.gif

Figure 2. Ridges and fissures in a cerebriform pattern with yellowish grey globules and papillary appearance.

b3962dd3-627c-438a-a518-6a7f096940f6_figure3.gif

Figure 3. There are immature and mature sebaceous gland with sebaceous hyperplasia along with primitive hair follicles with acanthosis, acanthosis, papillomatosis and mild hyperkeratosis of epidermis.

Discussion

Nevus sebaceous is a condition that appears at birth and increases in size with age. The exact cause of this condition is still uncertain, but recent studies have shown that it may be linked to women who have tested positive for the human papillomavirus or carry mutations in the PTCH gene.5,6

Nevus sebaceous can present as one of the manifestations of Epidermal Nevus Syndrome.7 There are some hereditary syndromes, including didymosis aplasticosebacea and SCALP (sebaceous nevus, central nervous system malformations, aplasia cutis congenita, limbal dermoid, and pigmented nevus) syndrome, that may present nevus sebaceous as a symptom. This condition typically appears as a smooth, yellowish-orange, round, oval, or linear plaque, mostly on the scalp, leading to alopecia.5

A previous study found that nevus sebaceous can occur in multiple locations, similar to verrucous epidermal nevi.8 Nevus sebaceous is rarely reported in the literature to affect the scalp and ipsilateral side of the face.9 In our case, the scalp and the ipsilateral side of the face were affected.

Several discussions have taken place regarding the emergence of secondary benign and malignant tumors inside the nevus sebaceous. While basal cell carcinoma development has been documented by multiple authors in adults, recent reports have also identified atypical malignant neoplasms such as eccrine porocarcinoma, sebaceous carcinoma, apocrine carcinoma, and squamous cell carcinoma developing inside the NS.10,11

There is a risk of developing malignant tumors in the Nevus Sebaceous. To detect these tumors accurately, non-invasive techniques like High-frequency Ultrasound and Reflectance Confocal Microscopy are used. These techniques help in visualizing the skin and skin appendages for accurate depth and lateral border detection. Reflectance Confocal Microscopy is particularly useful as it allows for in vivo evaluation of lesions and shows both anatomical features and individual cells.12,13 The presence of PTCH deletion, HRAS, and KRAS mutation can lead to malignant transformation in the nevus sebaceous.14

Although the timing of resection for nevus sebaceous therapy is debatable, most researchers feel that surgical excision is the preferred course of action. However, surgical excision to remove nevus sebaceous creates a linear scar. There are various therapeutic options, such as CO2 laser therapy, to reduce scarring. However, CO2 laser vaporization completely eradicates the sebaceous section of the nevus, which is located in the epidermis or papillary dermis.15

Conclusions

The primary take-away lesson from our case is as follows: We describe a unique example of a sebaceous nevus that affected the scalp and ipsilateral side of the face. As this hamartomatous growth carries the risk of cancer development, a dermatologist must identify the condition and begin treatment before malignant transformation occurs. This example of multiple verrucous plaques is an exception.

Consent

Written informed consent for publication of their clinical details and clinical images was obtained from the relatives of the patient.

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Version 2
VERSION 2 PUBLISHED 27 Nov 2023
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Rusia K, Madke B, Meghe S and Kashikar Y. Case Report: Leathery black plaque on the temple and scalp [version 2; peer review: 2 approved]. F1000Research 2024, 12:1514 (https://doi.org/10.12688/f1000research.142548.2)
NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article.
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Open Peer Review

Current Reviewer Status: ?
Key to Reviewer Statuses VIEW
ApprovedThe paper is scientifically sound in its current form and only minor, if any, improvements are suggested
Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit.
Not approvedFundamental flaws in the paper seriously undermine the findings and conclusions
Version 2
VERSION 2
PUBLISHED 08 Apr 2024
Revised
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Reviewer Report 02 May 2024
Aswath Rajan, Goa Medical College, Goa, India 
Approved
VIEWS 3
Well written, ... Continue reading
CITE
CITE
HOW TO CITE THIS REPORT
Rajan A. Reviewer Report For: Case Report: Leathery black plaque on the temple and scalp [version 2; peer review: 2 approved]. F1000Research 2024, 12:1514 (https://doi.org/10.5256/f1000research.164539.r264025)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
Version 1
VERSION 1
PUBLISHED 27 Nov 2023
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Reviewer Report 28 Mar 2024
Aswath Rajan, Goa Medical College, Goa, India 
Approved with Reservations
VIEWS 10
Article is very well written. However here are following few suggestions/queries that could add more value to it.
I had copied your statement mentioned in bold letters and its queries below it. here as follows, 

1. "As ... Continue reading
CITE
CITE
HOW TO CITE THIS REPORT
Rajan A. Reviewer Report For: Case Report: Leathery black plaque on the temple and scalp [version 2; peer review: 2 approved]. F1000Research 2024, 12:1514 (https://doi.org/10.5256/f1000research.156109.r251438)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
  • Author Response 13 Apr 2024
    Kaveri Rusia, Department of Dermatology, Datta Meghe Institute of Higher Education and Research, Wardha, 442001, India
    13 Apr 2024
    Author Response
    Thank you for your comments.

    1)  We confirmed on clinical grounds that there were no clinical signs in the lesion to undergo a malignant transformation like ulceration, bleeding from ... Continue reading
COMMENTS ON THIS REPORT
  • Author Response 13 Apr 2024
    Kaveri Rusia, Department of Dermatology, Datta Meghe Institute of Higher Education and Research, Wardha, 442001, India
    13 Apr 2024
    Author Response
    Thank you for your comments.

    1)  We confirmed on clinical grounds that there were no clinical signs in the lesion to undergo a malignant transformation like ulceration, bleeding from ... Continue reading
Views
9
Cite
Reviewer Report 23 Feb 2024
Dipanjan Basu, Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA 
Approved
VIEWS 9
Nevus sebaceous of Jadassohn is known as a rare congenital malformation, grouped under hamartomas. Etiology is thought to be driven by somatic post-zygotic mutations in RAS genes among others. The clinical manifestation occurs as plaques and is commonly found on ... Continue reading
CITE
CITE
HOW TO CITE THIS REPORT
Basu D. Reviewer Report For: Case Report: Leathery black plaque on the temple and scalp [version 2; peer review: 2 approved]. F1000Research 2024, 12:1514 (https://doi.org/10.5256/f1000research.156109.r241167)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
  • Author Response 13 Apr 2024
    Kaveri Rusia, Department of Dermatology, Datta Meghe Institute of Higher Education and Research, Wardha, 442001, India
    13 Apr 2024
    Author Response
    Thank you for your response.
    Competing Interests: No competing interests
COMMENTS ON THIS REPORT
  • Author Response 13 Apr 2024
    Kaveri Rusia, Department of Dermatology, Datta Meghe Institute of Higher Education and Research, Wardha, 442001, India
    13 Apr 2024
    Author Response
    Thank you for your response.
    Competing Interests: No competing interests

Comments on this article Comments (0)

Version 2
VERSION 2 PUBLISHED 27 Nov 2023
Comment
Alongside their report, reviewers assign a status to the article:
Approved - the paper is scientifically sound in its current form and only minor, if any, improvements are suggested
Approved with reservations - A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit.
Not approved - fundamental flaws in the paper seriously undermine the findings and conclusions
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