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Systematic Review
Revised

Antibiotic versus surgery in the treatment of acute appendicitis in the pregnant population: A systematic review and meta-analysis

[version 2; peer review: 2 approved, 1 approved with reservations]
PUBLISHED 06 Sep 2023
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Abstract

Introduction: Acute appendicitis is the most common surgical emergency in pregnant women. There has been a wide variance in clinical practice worldwide, with some favoring an antibiotic-only approach while others prefer surgery as the first-line management. Therefore, we designed the current analysis to synthesize the available evidence on the efficacy and safety of antibiotics versus surgery management.
Methods: We searched PubMed, Scopus, EuropePMC, and Cochrane Central from March 4, 1904 until November 25, 2022, to look for studies comparing antibiotics and surgery in pregnant patients with acute appendicitis. We only included studies that provided a comparison between the two treatments. Measured outcomes included preterm delivery, fetal loss, maternal death, and complications, defined as those arising from the pathological processes or treatment, including, but not limited to, sepsis or septic shock, pneumonia, venous thromboembolism (VTE), and surgical site infection. The results were compared using an odds ratio and 95% confidence interval. We also performed a sensitivity analysis by excluding studies with a serious risk of bias.
Results: We included five non-randomized studies for the analysis. We found that patients in the antibiotic group had a lower risk of preterm labor (OR 0.63 [95% CI 0.43–0.92]; p 0.02) but a higher risk of complications (OR 1.79 [95% CI 1.19–2.69]; p 0.005). We did not find any difference in the other outcomes.
Conclusion: The increased risk of complications should caution clinicians about using antibiotics as the first-line management. More studies are required to identify patients who would benefit the most before antibiotics could be adopted as a treatment for acute appendicitis in pregnant patients.

Keywords

Antibiotic, Surgery, Acute Appendicitis, Pregnant

Revised Amendments from Version 1

We revised the abstract and keywords to provide better understanding to the readers. We added two updated and more comprehensive journals as references.

See the authors' detailed response to the review by Rıfat Peksöz

Introduction

The prevalence of acute appendicitis in pregnancy is quite high, making it one of the most common surgical emergencies in the pregnant population. Its prevalence ranges from 1 in 700 to 1500 live births.13 Although not as common as other non-surgical emergencies, acute appendicitis has dire consequences both for the mother and her fetus. Acute appendicitis correlates with placental abruption, preterm labor, fetal loss, and even maternal death.

Acute appendicitis in pregnancy could be treated with surgery, either open or laparoscopic appendectomy, or with antibiotics alone. The 2020 update of the World Society of Emergency Surgery (WSES) Jerusalem guidelines gave a low-strength recommendation against treating acute appendicitis non-operatively during pregnancy and recommended using laparoscopic appendectomy.4 One of the reasons for this recommendation was the lack of high-level evidence, where they only considered three studies, of which two were case reports. As a result, clinical practices regarding the treatment of acute appendicitis in pregnancy worldwide continued to vary from one region to another. In Korea, 25% of pregnancy affected by acute appendicitis was treated conservatively,5 compared to 63% in China,6 67% in Japan,7 and 45% in the United States of America.8 This wide variance and high usage of conservative strategy could mean that not all clinicians adopted the existing guideline.

Some considerations for treating acute appendicitis conservatively were the lack of surgical resources, patient’s preference, and uncomplicated type of appendicitis. There has also been controversy regarding the type of appendectomy, with one systematic review reporting a higher proportion of fetal loss in patients treated with laparoscopic appendectomy.9 Moreover, two meta-analyses have reported that antibiotics treatment alone for uncomplicated appendicitis in the general population had a lower rate of complications, with an acceptable, albeit lower, rate of success.10,11 Therefore, seeing the lack of strong evidence and variance in clinical practice, we planned the current review to identify the efficacy and safety of conservative treatment in the treatment of acute appendicitis in pregnancy.

Methods

Database and literature search

We searched PubMed, Scopus, EuropePMC, and Cochrane Central from the March 4, 1904 until November 25, 2022, using the following keywords: [“acute appendicitis” or “appendicitis” and “pregnancy” and “conservative” or “antibiotic” or “antibiotics”]. We also reviewed the bibliographies of relevant studies to identify any other studies. We only included English-language literature. The initial search and screening were done by two independent authors. Any discrepancies were resolved by discussion with a third author.

Study selection/design

The inclusion criteria were: 1) types of patients: pregnant patients with uncomplicated and complicated acute appendicitis; 2) types of intervention: conservative management with antibiotics alone; 3) types of comparison: open or laparoscopic appendectomy; 4) analyzed outcomes: preterm delivery, fetal loss, maternal death, and complications; and 5) types of studies: prospective and retrospective studies. We defined complications as those arising from the pathological processes or treatment, including, but not limited to, sepsis or septic shock, pneumonia, venous thromboembolism (VTE), and surgical site infection. Studies that did not provide the aforementioned variables as outcomes were excluded. We excluded review articles, editorials, case reports, and case series. This analysis was started in July 31, 2022 and finished in November 9, 2022.

Data extraction

After the studies were selected, two authors independently extracted the data on study authors, publication year, study design, patients’ characteristics, treatment characteristics, and outcomes using a standardized form. Patients were then dichotomized according to the treatment they received.

Statistical analysis

We inputted patients’ data in a 2-by-2 contingency table according to the analyzed outcomes. We compared each outcome between conservative and surgical groups using odds ratios (OR) and 95% confidence intervals (CI). Heterogeneity among studies was evaluated using the I2 statistic and Cochrane Q-statistic test. An I2 value higher than 40% or a P value higher than 0.10 indicated a significant presence of heterogeneity. However, a random-effect model was used regardless of heterogeneity because we expected the studies to have significant differences in the choice of antibiotics. We also planned a subgroup analysis according to whether the studies’ participants had uncomplicated or complicated appendicitis. As performing a randomized controlled trial on a pregnant population is ethically difficult, we expected most studies to be non-randomized. Therefore, we also planned a sensitivity analysis by excluding studies with a serious risk of bias.

We assessed the risk of bias using the Cochrane risk-of-bias tool (The Cochrane Collaboration) for randomized studies and the Risk of Bias in Non-randomized Studies - of Intervention tool (ROBINS-I) for non-randomized studies. We used a funnel plot analysis to assess publication bias. We graded the strength of evidence for each outcome using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. We used the Review Manager version 5.4 (The Cochrane Collaboration) (https://training.cochrane.org/online-learning/core-software/revman/revman-5-download) program for all statistical analysis. We conducted this study according to the 2015 PRISMA guidelines for a systematic review. This review has been registered at The International Prospective Register of Systematic Reviews (PROSPERO) under the registration number CRD42022371119.

Results

Our initial search resulted in 3,275 records. After duplicate removal, 2,165 titles and abstracts were screened. This initial screening resulted in 92 studies being sought for retrieval. All studies were retrieved, and we assessed their full texts for eligibility. We excluded 87 studies because they did not provide a comparison between antibiotics and surgery and did not provide data on the outcomes we planned to analyze. Finally, five studies were included for final analysis (Figure 1).6,7,1214

e5c85e97-85a9-48ce-a099-dcb3d25058e7_figure1.gif

Figure 1. PRISMA flow diagram.

Study characteristics

The characteristics of the included studies are presented in Table 1. All of the studies were non-randomized and mostly retrospective. Patients were mostly 25 to 35 years old and in their second trimester. Liu et al. included only uncomplicated appendicitis case6 while Abbasi et al., Nakashima et al., and Vasileiou et al. included both complicated and uncomplicated appendicitis case.7,13 However, Yang et al. did not report the severity of appendicitis in their samples.14 Four studies reported their antibiotic use.6,7,12,14 Third-generation cephalosporin was the main choice. Five studies reported surgery type, and all used either open or laparoscopic appendectomy.6,7,12,14

Table 1. Characteristics of included studies.

Authors & yearStudy designCohort Size (n)Age (yrs)TrimesterComplicatedAntibioticsSurgeryOutcome
Abbasi et al., 20141Retrospective cohort413/6701<25: 42.5%; 25–25: 48.5%; >35: 9.0%Not specified7271 (20.3%)Not specifiedOpen and laparoscopicSIRS, sepsis, or severe sepsis; septic shock; peritonitis; VTE
Liu et al., 20216Retrospective cohort34/2029.0 ± 4.1 / 30.5 ± 4.81st trimester: 8 (23.5%) / 8 (40%); 2nd trimester: 20 (58.8%) / 9 (45%); 3rd trimester 6 (17.6%) / 3 (15%)All uncomplicatedCeftriaxone, ertapenem/meropenem, ceftriaxone + metronidazoleOpen and laparoscopicPreterm delivery; mode of delivery; fetal loss; birth weight; APGAR scores; postpartum complications; maternal death; LOS; recurrence.
Nakashima et al., 20217Retrospective cohort113/5629.7 ± 5.6 / 30.1 ± 4.21st trimester: 26 (23%) / 12 (21%); 2nd trimester: 54 (48%) / 33 (59%); 3rd trimester 31 (27%) / 9 (16%); unknown: 2 (2%) / 2 (4%)7 (6%) / 23 (41%)*2nd, 3rd, 4th generation cephalosporinOpen and laparoscopicFetal loss; maternal death; SSI; VTE; pneumonia; LOS
Vasileiou et al., 202013Prospective cohort6/3529 ± 7Not specified9 (25%)3rd generation cephalosporin, fluoroquinolene, clindamycin, aminoglicoside, sulfonamide, piperacillin/tazobactam, amoxicillin clavulanate, metronidazoleNot specifiedComplication; LOS
Yang et al., 202114Retrospective cohort2996/7275<20: 15%; 20–24: 21.8%; 25–29: 21.1%; 30–34: 17.6%; 35–49: 24.4%Not specifiedNot specifiedNot specifiedOpen and laparoscopicFetal loss; mode of delivery; preterm delivery

* Mean.

† Median.

We used the ROBINS-I tool to assess the risk of bias, and the results are presented in Table 2. We judged the study by Nakashima et al. to have a serious risk of bias because there was a significantly higher rate of complicated appendicitis in the surgery group. We assessed the remaining study to be of moderate risk of bias because confounding had been sufficiently controlled. However, the possibility of unmeasured confounding variables inherent in the design of non-randomized studies gave a moderate risk of confounding bias. We judged bias from the outcome measurement to be low because although no blinding was used, the outcomes were fairly objective. We did not perform analysis for publication bias because funnel plot analysis or other statistical methods did not have enough power to detect bias in a small number of studies.

Table 2. Risk of bias assessment The Risk of Bias in Non-Randomized Studies – of Interventions (ROBINS-I) tool.

AuthorsConfoundingSelectionIntervention classificationDeviation from interventionMissing dataMeasurement of outcomeSelection of reported resultsOverall
Abbasi et al., 20141ModerateLowLowLowLowLowLowModerate
Liu et al., 20216ModerateLowLowLowLowLowLowModerate
Nakashima et al., 20217SeriousLowLowLowLowLowLowSerious
Vasileiou et al., 202013ModerateLowLowLowLowLowLowModerate
Yang et al., 202114ModerateLowLowLowLowLowLowModerate

Preterm delivery

Two studies with a total of 10,325 patients assessed the occurrence of preterm labor. Overall, patients in the antibiotic group had a significantly lower risk of preterm delivery (OR 0.63 [95% CI 0.43–0.92]; p 0.02) (Figure 2).

e5c85e97-85a9-48ce-a099-dcb3d25058e7_figure2.gif

Figure 2. Forest plot showing preterm delivery between antibiotic and surgery group.

Fetal loss

Three studies with a total of 10,494 patients assessed the occurrence of fetal loss. Overall, there were no significant differences in fetal loss between the two groups (OR 1.02 [95% CI 0.84–1.24]; p 0.81) (Figure 3).

e5c85e97-85a9-48ce-a099-dcb3d25058e7_figure3.gif

Figure 3. Forest plot showing fetal loss between antibiotic and surgery group.

Maternal death

From the two studies with a total of 223 patients, there was no report of maternal death either in the antibiotic or the surgery group. Therefore, a meta-analysis could not be performed.

Complications

Four studies with a total of 7,378 patients assessed complications. Abbasi et al. included sepsis, septic shock, peritonitis, and VTE as complications. Liu et al. reported one grid iron complication in the surgery group. Nakashima et al. included surgical site infection, VTE, and pneumonia as complications. Lastly, Vasileiou et al. used Clavien-Dindo complications. Overall, there was a lower risk of complications in the antibiotic group, but it was not statistically significant (OR 0.72 [95% CI 0.16–3.32]; p 0.68) (Figure 4). However, only Abbasi et al. reported peritonitis, and they found that patients in the antibiotic group significantly had a higher rate of peritonitis (28.8% vs. 19.8%; p < 0.001).

e5c85e97-85a9-48ce-a099-dcb3d25058e7_figure4.gif

Figure 4. Forest plot showing complications between antibiotic and surgery group.

Sensitivity analysis

We excluded the study by Nakashima et al. in our sensitivity analysis. Regarding fetal loss, the result did not differ from our primary analysis. However, regarding the outcome, we found that patients in the antibiotic group significantly had a higher rate of complications (OR 1.79 [95% CI 1.19–2.69]; p 0.005) (Figure 5).

e5c85e97-85a9-48ce-a099-dcb3d25058e7_figure5.gif

Figure 5. Forest plot showing the sensitivity analysis for fetal loss (A) and complications (B) between antibiotic and surgery group.

Certainty of evidence

The certainty of the evidence was very low to low (Table 3). Evidence regarding fetal loss and complication had a serious risk of bias and inconsistency, so we judged them to be of very low quality. Evidence regarding fetal loss did not have serious concerns, but we assessed them to be of low quality due to the observational design of studies. Table 3 gives a summary of the assessment.

Table 3. Certainty of evidence.

OutcomeNo. of studiesStudy designRisk of biasInconsistencyIndirectnessImprecisionOther considerationOR (95% CI)Overall
Preterm delivery3ObservationalSerious*Not seriousNot seriousSeriousPlausible residual confounding, would suggest spurious effect1.02 (0.84 – 1.24)Very low
Fetal loss2ObservationalNot seriousNot seriousNot seriousNot seriousNone0.63 (0.43 – 0.92)Low
Complication4ObservationalSerious*SeriousNot seriousSeriousPlausible residual confounding, would suggest spurious effect0.72 (0.16 – 3.32)Very low

* One study rated as having a serious risk of bias. Downgraded by one point.

† 95% CI overlaps no effect. Downgraded by one point.

I2 > 40%. Downgraded by one point.

Discussion

Our analysis showed that conservative management of acute appendicitis in pregnant patients resulted in a lower risk of preterm labor (OR 0.63 [95% CI 0.43–0.92]; p 0.02). The rate of complications in our primary analysis was also comparable between the two groups. However, after excluding the study by Nakashima et al. in our sensitivity analysis, we found that antibiotic treatment resulted in a significantly higher risk of complications (OR 1.79 [95% CI 1.19–2.69]; p 0.005). The result of this analysis mainly came from the study by Abbasi et al., which had the highest number of participants. Abbasi et al. was also the only one that reported the occurrence of sepsis and peritonitis.12 Several newer studies have suggested that conservative management is a safe option in treating acute appendicitis in the pregnant population.6,7,13 Interestingly, none of those studies found any occurrence of sepsis and peritonitis. We suspected those studies did not have adequate statistical power to detect those complications. Immunological changes during pregnancy are one of the possible reasons for an increase in infectious complication, such as peritonitis and sepsis. Immune response in patients with acute appendicitis includes increased neutrophil and C-reactive Protein (CRP).15,16 During pregnancy, there is evidence of increased neutrophil activation, but its activity and phagocytosis function are limited.17 In conclusion, decreased activities of activated neutrophils in pregnancy may explain higher rates of infectious complications, such as sepsis, in the pregnant population.

Another concern is the difference in the number of patients with complicated appendicitis. Abbasi et al. in their study, had 20.3% of the study population diagnosed with complicated appendicitis,12 Vasileiou et al. had 25%,13 while Liu et al. only included patients with uncomplicated appendicitis.6 Liu et al. in their study, expectedly did not report a higher complication rate in the antibiotic group.6 However, Vasileiou et al., comparable with the study by Abbasi et al. in terms of patients with complicated appendicitis also reported a lower rate of complication.13 This made it difficult to arrive at a definite conclusion on whether patients with complicated appendicitis could benefit from conservative management.

Despite a higher risk of complications, we found that conservative management reduced the risk of preterm labor. Therefore, the potential benefits of conservative management should not be crossed out just yet. Two meta-analyses on non-pregnant patients also concluded that conservative management is a viable option.10,11 Aside from the studies included in the analysis, there were two studies that also supported the use of antibiotic for acute appendicitis in the pregnant population. However, we excluded those two studies because they did not provide a comparison with a control group.5,18 Rather than focusing solely on comparing the efficacy and safety between conservative and surgical approaches, more attention should be given to tailoring a strategy for each patient. Several studies have identified predictors for the failure of conservative management in non-pregnant patients, such as high serum C-reactive protein, presence of appendicolith, diabetes, longer duration of symptoms, higher temperature, higher Alvarado score, and larger appendiceal diameter.1921 However, those studies only studied patients with uncomplicated appendicitis.

Diagnosis of acute appendicitis in pregnancy also has its consideration. Negative appendectomy in the pregnant population ranges from 25 to 50%, higher than those in the general population, which only ranges from 15 to 35%.22 To reduce unneeded surgery, radiographical imaging is usually ordered to supplement the diagnosis. As computed tomography (CT) scan is often contraindicated in pregnant patients, ultrasonography and magnetic resonance imaging (MRI) are the main radiographical modalities for diagnosing appendicitis. As ultrasonography has a low sensitivity and specificity, MRI is often warranted in patients with a negative ultrasonography finding.23,24 However, MRI is not widely available, especially in low to middle-income settings. Therefore, in those settings, it can be expected that a significant number of pregnant patients with suspected appendicitis would receive a misdiagnosis. In a pregnant patient with a doubtful clinical presentation of acute appendicitis and a negative ultrasonography finding, a conservative approach might be appropriate as first-line management. However, a surgical approach should always be preferred for a patient with a set of specific and characteristic symptoms of acute appendicitis.

We listed comparison as surgical treatment, either open or laparoscopic based on insufficient evidence of suspected association between laparoscopic appendectomy and miscarriage. Compared with open appendectomy, laparoscopic appendectomy was associated with lower wound infection rates and shorter LOS. Based on our results and recent literatures, we suggest that laparoscopic appendectomy shows non-inferior safety with respect to pregnancy outcomes but superior with regard to surgical outcomes compared with open appendectomy in pregnant women with suspected appendicitis.25 Furthermore, resources needed to carry out laparoscopic procedures in developing countries are still limited - hence open appendectomy remains a viable and equal option.24

One limitation of the available studies on this subject is the lack of information on whether appendicitis recurred or not after conservative management. Vasileiou et al. reported that patients in the antibiotic and surgery group had a comparable emergency department (ED) return rate after 30 days.13 However, they did not specify the reason for the ED visit. One meta-analysis by Sallinen et al. found that 8.5% of patients in the antibiotic group required an appendectomy within one month.10 Future studies intending to study conservative management for acute appendicitis in pregnant patients should include recurrence as one of the outcomes.

Additionally, the use of tocolytic agents was not mentioned in any of the journals included in this review. Although there had been some evidence in the past regarding the function of tocolytic agents administration for pregnant women undergoing surgery, latest systematic review and recommendation do not recommend its use because it has not been shown to improve outcomes.26 Lastly, the studies did not provide information regarding complications in accordance with each trimester. There has been evidence in the past regarding lower risk of acute appendicitis in the third trimester of pregnancy, therefore, future studies should evaluate any complication in accordance with the patients’ trimester.27

Our analysis has several limitations. One limitation is the small number of studies and the non-randomized design. It is indeed difficult to perform a clinical trial on pregnant patients. Therefore, future cohorts should be carefully designed as they are the main modality to address this issue. Another limitation is the potential risk of confounding bias. We addressed this issue by performing a sensitivity analysis. However, unmeasured confounding inherent in the design of cohort studies remained a problem.

Conclusion

Patients in the antibiotic group had a significantly lower risk of preterm labor but a higher risk of complications. Seeing the result and the available evidence, we suggested that conservative management should not be given indiscriminately to pregnant patients until it is found which patients could benefit the most from such a strategy. Conservative management must also be given with close and routine monitoring to prevent life-threatening complications, such as sepsis and peritonitis. Nevertheless, the potential benefit should warrant future studies addressing the identified concerns, namely patient selection and recurrence.

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Candrawinata V, Hanafi R, Baskoro BA et al. Antibiotic versus surgery in the treatment of acute appendicitis in the pregnant population: A systematic review and meta-analysis [version 2; peer review: 2 approved, 1 approved with reservations]. F1000Research 2023, 12:188 (https://doi.org/10.12688/f1000research.129906.2)
NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article.
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ApprovedThe paper is scientifically sound in its current form and only minor, if any, improvements are suggested
Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit.
Not approvedFundamental flaws in the paper seriously undermine the findings and conclusions
Version 2
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Reviewer Report 08 Jul 2024
Goran Augustin, University of Zagreb, Zagreb, Croatia 
Approved with Reservations
VIEWS 8
A small number of studies were included. All were retrospective and non-randomized. Difficult to compare. it is unexpected that antibiotic treatment results in more complications. This bias is due to a population-based study of Abbas with more than 7000 people. ... Continue reading
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Augustin G. Reviewer Report For: Antibiotic versus surgery in the treatment of acute appendicitis in the pregnant population: A systematic review and meta-analysis [version 2; peer review: 2 approved, 1 approved with reservations]. F1000Research 2023, 12:188 (https://doi.org/10.5256/f1000research.155547.r294632)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
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Reviewer Report 24 Jun 2024
kumar Hari Rajah, Taylors University School of Medicine and Health Science, Selangor, Malaysia 
Approved
VIEWS 3
This systemic review and meta-analysis on antibiotic versus surgery in the management of acute appendicitis in pregnancy. I would suggest adding laparoscopic appendectomy and open appendectomy to the keywords. The PRISMA guide is done properly and the studies and type ... Continue reading
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Hari Rajah k. Reviewer Report For: Antibiotic versus surgery in the treatment of acute appendicitis in the pregnant population: A systematic review and meta-analysis [version 2; peer review: 2 approved, 1 approved with reservations]. F1000Research 2023, 12:188 (https://doi.org/10.5256/f1000research.155547.r294634)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
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Reviewer Report 26 Sep 2023
Rıfat Peksöz, Department of General Surgery, Faculty of Medicine, Ataturk University, Erzurum, Erzurum, Turkey 
Approved
VIEWS 6
Necessary revisions have been made. ... Continue reading
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Peksöz R. Reviewer Report For: Antibiotic versus surgery in the treatment of acute appendicitis in the pregnant population: A systematic review and meta-analysis [version 2; peer review: 2 approved, 1 approved with reservations]. F1000Research 2023, 12:188 (https://doi.org/10.5256/f1000research.155547.r204328)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
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Reviewer Report 01 Sep 2023
Rıfat Peksöz, Department of General Surgery, Faculty of Medicine, Ataturk University, Erzurum, Erzurum, Turkey 
Approved with Reservations
VIEWS 14
The authors aimed to investigate the current review to identify the efficacy and safety of conservative treatment in the treatment of acute appendicitis in pregnancy in this study.

Acute appendicitis is the most frequently seen surgical emergency ... Continue reading
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Peksöz R. Reviewer Report For: Antibiotic versus surgery in the treatment of acute appendicitis in the pregnant population: A systematic review and meta-analysis [version 2; peer review: 2 approved, 1 approved with reservations]. F1000Research 2023, 12:188 (https://doi.org/10.5256/f1000research.142624.r195177)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
  • Author Response 06 Oct 2023
    Valeska Candrawinata, Faculty of Medicine, Pelita Harapan University, Tangerang, 15811, Indonesia
    06 Oct 2023
    Author Response
    Dear Reviewer, we thank you for your kind review and insightful notes. We have revised the manuscript accordingly.
    1. In the Abstract section, the complications which are seen more
    ... Continue reading
COMMENTS ON THIS REPORT
  • Author Response 06 Oct 2023
    Valeska Candrawinata, Faculty of Medicine, Pelita Harapan University, Tangerang, 15811, Indonesia
    06 Oct 2023
    Author Response
    Dear Reviewer, we thank you for your kind review and insightful notes. We have revised the manuscript accordingly.
    1. In the Abstract section, the complications which are seen more
    ... Continue reading

Comments on this article Comments (0)

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Approved - the paper is scientifically sound in its current form and only minor, if any, improvements are suggested
Approved with reservations - A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit.
Not approved - fundamental flaws in the paper seriously undermine the findings and conclusions
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