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Case Report
Revised

Case Report: Concomitant presence of two STIs in a male patient

[version 2; peer review: 2 approved, 2 approved with reservations]
PUBLISHED 12 Jun 2024
Author details Author details
OPEN PEER REVIEW
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This article is included in the Datta Meghe Institute of Higher Education and Research collection.

Abstract

Background

The spirochaete Treponema pallidum subsp. pallidum, which causes the infectious disease syphilis, can be spread through sexual contact or perinatal transmission. In recent years, cases of syphilis have increased, especially among individuals engaging in behaviour that makes them more vulnerable (condomless sex and multiple sexual partners). Condylomata acuminata (external genital warts) is one of the most common viral sexually transmitted infections (STIs). Individuals who are behaviourally vulnerable are also highly prone to two or more STIs. Our case exemplifies the occurrence of two STIs in a young man who was behaviourally vulnerable to acquiring STIs.

Case

We report a case of a 21-year-old year old heterosexual man presenting with concomitant primary syphilis and genital warts. He presented with a painless genital ulcer and warty growths on his glans penis. Examination showed a painless indurated ulcer and multiple genital warts. Serology was positive for quantitative Venereal disease research laboratory test (1:16 titre). The patient was diagnosed with two concomitant STIs. He was treated as per the latest Centers for Disease Control and Prevention (CDC) guidelines for primary syphilis and podophyllin resin for genital warts. After four weeks, the genital ulcer showed complete healing and there was a significant reduction of genital warts.

Conclusions

Individuals with multiple sexual partners engaging in sexual activity without the use of prevention tools are at a greater chance of acquiring two or more STIs. To reduce concomitant transmission, preventive measures against genital ulcer diseases like syphilis, herpes, and chancroid, such as early identification and treatment, and condom distribution, must be strengthened as part of national STI prevention. Patients with two or more STIs should be followed regularly to assess the progress of infection and should be offered timely medical treatment.

Keywords

Syphilis, genital warts, HPV, treponema, STI

Revised Amendments from Version 1

There are some minor grammatical corrections in the manuscript.

See the authors' detailed response to the review by Electra Nicolaidou

Introduction

Genital ulcer diseases (GUDs) are breaks in the skin and mucosal continuity in the genital and perigenital region, usually resulting from sexually transmitted infections (STIs). Syphilis is a multisystemic, multistage, chronic illness with a varied prognosis and myriad of clinical presentations.1 Anogenital warts, are also called condyloma acuminata, are one of the most common STIs in the developed world, with a frequency of 2.4 infections per 1,000 people per year.2,3 Individuals engaging in behaviour that makes them more vulnerable (sex without the use of prevention tools and multiple sexual partners) are at increased likelihood of acquiring two or more STIs. Presence of one STI increases the likelihood for acquiring another STI and our case exemplifies the aforementioned phenomenon. Our case presented with two concomitant STIs, one being bacterial and the other being viral in aetiology.

Case report

A 21-year-old male resident of Central India studying at a local college presented to the Dermatology Outpatient Department of the Datta Meghe Institute of Higher Education and Research affiliated tertiary care teaching hospital at Sawangi, Wardha, Maharashtra with complaints of a painless genital ulcer and warty growths on his penis. He reported that the warty lesions had been present for the past two months and the ulcerative lesion appeared three weeks ago. Detailed sexual history revealed regular, penile–vaginal intercourse without the use of prevention tools with sex workers (SWs) for the past six months in his home town, with the last occurrence being approximately four weeks before he presented to our hospital. His general physical examination was within normal limits. There was no history of burning micturition and pus discharge through the urethra. There was a single, painless, indurated ulcer of 3×3 cm in size with rolled edges and minimal discharge on the penis at the coronal sulcus (Figure 1). Glans penis showed cauliflower floret-like growths on the coronal sulcus and sub-preputial area of the penis (Figure 2). There was no regional lymphadenopathy. Detailed muco-cutaneous examination of the oral cavity, perianal area and palms and soles were normal. The quantitative Venereal Disease Research Laboratories (VDRL) test was reactive in the titre of 1:16, however the test for treponema pallidum haemagglutination (TPHA) was non-reactive. Serological tests for hepatitis B virus, hepatitis C virus and human immunodeficiency virus (HIV) were negative. On the basis of sexual history, temporal relation, clinical examination and serology, we made a diagnosis of concomitant STIs of primary syphilis and genital warts.

f7479974-a6af-4f63-b6e7-92ddd6f1099a_figure1.gif

Figure 1. A single clean ulcer on the coronal sulcus.

f7479974-a6af-4f63-b6e7-92ddd6f1099a_figure2.gif

Figure 2. Whitish pink growth on the coronal sulcus.

We treated the patient with office-based topical application of podophyllin resin (20% w/v) in benzoin (10% w/v) on the genital warts, while the surrounding healthy skin area was protected with petrolatum. Applications were carried out every 10 days until complete clearance of warty lesions. Primary syphilis was treated with a two intramuscular injection of benzathine penicillin (2.4 million units, 1.2 million units in each buttock) after the sensitivity test. Contact tracing is being attempted for the sexual partners for the past three months. On a follow-up visit, the lesion of primary syphilis and genital warts had completely resolved (Figure 3).

f7479974-a6af-4f63-b6e7-92ddd6f1099a_figure3.gif

Figure 3. Resolution of genital ulcer and wart after receiving single dose of injectable benzathine penicillin and after application of podophyllin resin at day 30.

Discussion

Syphilis is a disease caused by the bacteria Treponema pallidum that has a myriad of clinical presentations and is referred to as a “great mimicker” in clinical medicine. Immune evasion and invasiveness are two important pathogenic traits of Treponema pallidum.47 Wu et al.,7conducted a study where it was found that there is a higher prevalence of syphilis among individuals living with HIV, especially among men who have sex with men. The presence of one STI increases the likelihood that the individual will acquire another STI. The presence of genital ulcer disease increases the risk of acquiring HIV due to mucosal damage and the pool of inflammatory cells at the site of ulcers.7

In a study by Kops et al., it was shown that there are higher chances of acquiring human papilloma virus (HPV) if an individual has an STI.6 A history of prior STI leads to decreased clearance of HPV load and provides an easy access for viral entry into the damaged epithelial barrier. The various factors associated with increased likelihood of concomitant STIs are smoking, substance use disorder and men having sex with men.7

The presence of concomitant STIs suggests the person is behaviourally vulnerable. Individuals with multiple STIs should be investigated for the presence of other venereal transmitted diseases, particularly HIV and hepatitis B virus infection, and appropriate laboratory work-up should be done to confirm the diagnosis.

The primary take-away lesson from our case is as follows: individuals with multiple sexual partners and involved in sexual activity without the use of prevention tools are at greater chance of acquiring two or more STIs. Attempts should be made to perform partner tracing of such cases and individuals should be offered counselling and appropriate medical management. Patients with two or more STIs should be followed regularly to assess the progress of infection and should be offered timely medical treatment.

Consent

Written informed consent for publication of their clinical details and clinical images was obtained from the patient.

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Version 2
VERSION 2 PUBLISHED 20 Jun 2023
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CITE
how to cite this article
Rusia K, Madke B and Kashikar Y. Case Report: Concomitant presence of two STIs in a male patient [version 2; peer review: 2 approved, 2 approved with reservations]. F1000Research 2024, 12:706 (https://doi.org/10.12688/f1000research.134667.2)
NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article.
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Open Peer Review

Current Reviewer Status: ?
Key to Reviewer Statuses VIEW
ApprovedThe paper is scientifically sound in its current form and only minor, if any, improvements are suggested
Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit.
Not approvedFundamental flaws in the paper seriously undermine the findings and conclusions
Version 2
VERSION 2
PUBLISHED 12 Jun 2024
Revised
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0
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Reviewer Report 22 Aug 2024
Giulia Ciccarese, Unit of Dermatology, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy 
Approved with Reservations
VIEWS 0
The case is interesting and deals with a very important topic, the frequent concomitance of multiple sexually transmitted infections (STIs). However, several details are lacking. Was the patient tested for other sexually transmitted infections, as Neisseria gonorrhoeae, Mycoplasmas , Chlamydia ... Continue reading
CITE
CITE
HOW TO CITE THIS REPORT
Ciccarese G. Reviewer Report For: Case Report: Concomitant presence of two STIs in a male patient [version 2; peer review: 2 approved, 2 approved with reservations]. F1000Research 2024, 12:706 (https://doi.org/10.5256/f1000research.167723.r310539)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
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2
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Reviewer Report 16 Aug 2024
David Šmajs, Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic 
Eliška Vrbová, Masaryk University Faculty of Medicine, Department of Biology, Brno, South Moravian Region, Czech Republic 
Approved
VIEWS 2
The authors in their report described a case of 21-year-old man diagnosed simultaneously with genital warts and primary syphilis. This case underlines importance of syphilis testing even in the presence of other STIs, and also the need for the follow-up ... Continue reading
CITE
CITE
HOW TO CITE THIS REPORT
Šmajs D and Vrbová E. Reviewer Report For: Case Report: Concomitant presence of two STIs in a male patient [version 2; peer review: 2 approved, 2 approved with reservations]. F1000Research 2024, 12:706 (https://doi.org/10.5256/f1000research.167723.r310534)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
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8
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Reviewer Report 03 Jul 2024
Electra Nicolaidou, 1st Department of Dermatology and Venereology, National and Kapodistrian University of Athens, Athens, Greece 
Approved with Reservations
VIEWS 8
Thank you for answering most of my comments. The first comment, however, as well as the 6th, were not followed by changes in the text. The authors may want to explain to the readers why the used podophillin for the ... Continue reading
CITE
CITE
HOW TO CITE THIS REPORT
Nicolaidou E. Reviewer Report For: Case Report: Concomitant presence of two STIs in a male patient [version 2; peer review: 2 approved, 2 approved with reservations]. F1000Research 2024, 12:706 (https://doi.org/10.5256/f1000research.167723.r290390)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
  • Author Response 10 Jul 2024
    Kaveri Rusia, Department of Dermatology, Venereology and Leprosy, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, 442001, India
    10 Jul 2024
    Author Response
    Thank you for your response. 

    Author response Review Report Point 1:
    I have used podophyllin as it is easily available in our setting.

    Author response Review Report Point ... Continue reading
COMMENTS ON THIS REPORT
  • Author Response 10 Jul 2024
    Kaveri Rusia, Department of Dermatology, Venereology and Leprosy, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, 442001, India
    10 Jul 2024
    Author Response
    Thank you for your response. 

    Author response Review Report Point 1:
    I have used podophyllin as it is easily available in our setting.

    Author response Review Report Point ... Continue reading
Version 1
VERSION 1
PUBLISHED 20 Jun 2023
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Cite
Reviewer Report 07 May 2024
Alessandra Latini, San Gallicano Dermatological Institute IRCCS, Rome, Italy 
Approved
VIEWS 3
The paper, Concomitant presence of two STIs in a male patient, by Rusia K et al  describes the case of a young heterosexual student who presents with two sexually transmitted infections at the same time as ghenital warts and syphilis. ... Continue reading
CITE
CITE
HOW TO CITE THIS REPORT
Latini A. Reviewer Report For: Case Report: Concomitant presence of two STIs in a male patient [version 2; peer review: 2 approved, 2 approved with reservations]. F1000Research 2024, 12:706 (https://doi.org/10.5256/f1000research.147742.r266151)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
Views
14
Cite
Reviewer Report 15 Feb 2024
Electra Nicolaidou, 1st Department of Dermatology and Venereology, National and Kapodistrian University of Athens, Athens, Greece 
Approved with Reservations
VIEWS 14
This is a well written case report of a patient presenting with two concomitant STIs, syphilis and genital warts, that were typical in clinical appearance and responded well to treatment. The case is well presented.
My comments are as ... Continue reading
CITE
CITE
HOW TO CITE THIS REPORT
Nicolaidou E. Reviewer Report For: Case Report: Concomitant presence of two STIs in a male patient [version 2; peer review: 2 approved, 2 approved with reservations]. F1000Research 2024, 12:706 (https://doi.org/10.5256/f1000research.147742.r235347)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
  • Author Response 13 Apr 2024
    Kaveri Rusia, Department of Dermatology, Venereology and Leprosy, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, 442001, India
    13 Apr 2024
    Author Response
    Thank you for your responses. Necessary changes can be done according to your comments.
    I have used podophyllin as it is easily available in our setup.
    Competing Interests: No competing interests.
COMMENTS ON THIS REPORT
  • Author Response 13 Apr 2024
    Kaveri Rusia, Department of Dermatology, Venereology and Leprosy, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, 442001, India
    13 Apr 2024
    Author Response
    Thank you for your responses. Necessary changes can be done according to your comments.
    I have used podophyllin as it is easily available in our setup.
    Competing Interests: No competing interests.

Comments on this article Comments (0)

Version 2
VERSION 2 PUBLISHED 20 Jun 2023
Comment
Alongside their report, reviewers assign a status to the article:
Approved - the paper is scientifically sound in its current form and only minor, if any, improvements are suggested
Approved with reservations - A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit.
Not approved - fundamental flaws in the paper seriously undermine the findings and conclusions
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