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Research Article
Revised

Effect of thermocycling on flexural strength of dental CAD/CAM ceramics of variable thicknesses and structures: an in vitro study

[version 3; peer review: 3 approved, 1 not approved]
PUBLISHED 14 Aug 2025
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Abstract

Background

This study examined the effect of thermocycling on the flexural strength properties of four CAD/CAM ceramic materials at different thicknesses.

Methods

Four CAD/CAM ceramics of different types: advanced lithium disilicate (ALD), zirconia-reinforced lithium silicate (ZLS) lithium disilicate (LD), and leucite reinforced (LE), and at three varying thicknesses 0.5, 1.0 and 1.5 mm were examined. After subjecting all specimens to 5000 thermal cycles, flexural strength was determined using a universal testing apparatus. Scanning electron microscopy (SEM) was employed for analysis. Two factorial ANOVA models assessed the association of different factors (ceramic type and thickness) with flexural strength and elastic modulus. The 95% confidence intervals (CIs) and adjusted means were computed. A p-value < 0.05 was designated significant.

Results

ZLS exhibited the highest flexural strength at 1.5 mm thickness, while LD showed the highest Young’s modulus of elasticity. The lowest flexural strength was observed in the 0.5 mm thickness group of all tested groups. There were notable variations in flexural strength across all ceramic materials, with the highest adjusted mean strength in the ZLS group, ALD, LD, and LE, respectively. Additionally, significant differences were noted in ceramic thickness, with 1.5 mm thickness showing the highest strength and 0.5 mm thickness the lowest.

Conclusions

Ceramic material thickness significantly impacts flexural strength, with 1.5 mm thickness deemed suitable for posterior restorations. Ceramic materials with zirconia fillers or matrix demonstrated higher flexural strength than other ceramics.

Keywords

CAD/CAM, Ceramics, Flexural Strength, Thickness, Composition

Revised Amendments from Version 2

We thank the reviewer for their comments that are very important for improving our manuscript. 

The comments of the reviewer were applied to the document:
1. Adjusting the term of thermomechanical cycling to thermocycling.
2. Explaining the reason of firing after polishing precrystalized ceramics as well as adjusting the equations mentioned and the formulas of dental ceramics.
3. Adding additional reference comparing the effect of thickness on biaxial flexural strength.
4. Adding one more limitation which is effect of glazing on the flexural strength of different ceramic thickness and compositions.
5. Modification of figures based on reviewer comments.

To read any peer review reports and author responses for this article, follow the "read" links in the Open Peer Review table.

Introduction

Dental ceramics have evolved to offer restorations with superior esthetic and mechanical characteristics, serving as efficient alternatives to metal-ceramic restorations.1 These dental ceramics can be categorized based on their fabrication method, composition, firing temperature, and microstructure.2 All-ceramic restorations can be fabricated using different methods, including conventional techniques like stacking and sintering, split casting and infusion, and heat- or dry-pressing methods, as well as through computer-aided design and computer-aided manufacturing (CAD/CAM) techniques.2,3 The homogeneity of ceramic CAD/CAM blocks has notably enhanced the strength of definitive prostheses by reducing crack development and defects compared to conventional ceramic fabrication methods.4 Lithium disilicate glass-ceramic (LD) is one of the most common ceramic materials, with its (SiO2-Li2O) composition minimizing microcracks and enhancing mechanical properties.5,6 Previous studies have demonstrated LD’s higher fracture resistance compared to leucite ceramics and improved flexural strength over lithium disilicate-strengthened lithium aluminosilicate glass.7,8 Leucite glass-ceramic is another option for high-esthetic and translucent all-ceramic restorations, with comparable fracture strength to feldspathic ceramics and resin nano-ceramic.9

Lithium silicate CAD/CAM ceramics reinforced with zirconia (ZLS) integrate tetragonal zirconia fillers to improve ceramic strength, making them capable of withstanding occlusal forces.10 Despite ZLS being challenging to section due to drill blunting,11 its high biaxial flexural strength values have bolstered its utility in fabricating various restorations, including implant-supported molar crowns, occlusal veneers, and endo-crown restorations.12

Advanced lithium disilicate (ALD; Li0.5Al0.5Si2.5O6), comprises lithium disilicate (Li2Si2O5) and virgilite crystals (LiAlSi2O6) which form a 0.5-μm-long needle-like shape within a zirconia glass matrix.13 Research reporting the mechanical properties of ALD ceramics is scarce.14,15 One of the published studies showed some positive results regarding the mechanical fatigue behavior of ALD, which is similar to LD but lower than lithium silicate-disilicate and Yttria-stabilized zirconia14 In contrast, another study reported that ALD had lower fracture toughness15 as well as lower flexural strengths when compared to LD.16

The thickness and composition of ceramic restorations have a direct impact on flexural strength and esthetics, where varying restoration thicknesses offer solutions for some clinical challenges.17 For example, thinner restorations can be used for ceramic veneers of high esthetics and translucency,18 while thicker ceramics are more suitable for full-coverage restorations.19 To create a restorative dental material that is highly sustainable, aesthetically pleasing, and safe, all of the material’s qualities must be thoroughly examined and tested.20 Since chewing and biting put occlusal stress on all restorative materials used for tooth restorations, proper flexural strength is considered essential.16 The maximum stress a material can withstand deformation under load is known as flexural strength.21 On the other hand, the minimal and conflicting findings on ALD highlight the need for further studies to comprehensively assess its mechanical properties.1416 Additionally, understanding the impact of ceramic thickness and structure can guide the selection of appropriate restoration types for specific dental applications. Thus, this research aimed to evaluate the effect of thermocycling on the flexural strength of four CAD/CAM ceramics of varying thicknesses. According to the null hypothesis, no discernible relationship would be noticed between the flexural strength and the thickness and composition of CAD/CAM ceramics after exposure to thermocycling process.

Methods

Grouping of tested specimens

Four CAD/CAM ceramics of low translucency and A1 shade were examined; advanced lithium disilicate (Cerec Tessera™, Sirona Dentsply, Milford, DE, USA; ALD), zirconia-reinforced lithium silicate (Celtra Duo®, Sirona Dentsply, Milford, DE, USA; ZLS), lithium disilicate (IPS E.max® CAD, Ivoclar Vivadent, Schaan, Liechtenstein; LD), and leucite reinforced (IPS Empress® CAD, Ivoclar Vivadent, Schaan, Liechtenstein; LE) as shown in Figure 1. Each ceramic type included 30 specimens, further categorized into three thicknesses of 0.5-, 1-, and 1.5mm. (n=10 specimens per thickness subgroup). As a result, 120 specimens made up the entire sample size that was evaluated in this study. In order to detect an effect size of 0.42, the total sample was computed using G*Power (Version 3.1.9.4), assuming a 5% alpha error and 80% research power. The least number of specimens required for each group was determined to be 9. However, 10 specimens were included to account for possible problems with the laboratory process.22 As a consequence, the number of subgroups multiplied by the number of members in each subgroup yielded 12 × 10 = 120 specimens as the total sample size.23

0ecd6406-afeb-4393-9776-10cbeea3e73d_figure1.gif

Figure 1. Flow chart representing the study grouping and design.

Preparation of study specimens

The specimens were sectioned utilizing a precision cutting device (Isomet 5000 machine; Buehler, Lake Bluff, IL, USA) under an abundance of water to produce the following thicknesses of 0.5, 1, and 1.5 mm × 4 mm × 12 mm. Following the specimens’ cutting, a 60-second polishing period was conducted utilizing silicon carbide discs (500-grit coarse) at 200 rpm in the presence of a water-cooling system. The polishing was executed employing a polishing device (MetaServ 250 Grinder-Polisher with Vector Power Head; Buehler, IL, USA). Post-polishing, the pre-crystallized specimens were placed in a furnace of ceramic to crystallize. (Programat EP5010; Ivoclar Vivadent, Schann, Liechtenstein). Subsequently, an additional polishing step was performed utilizing the previously described polishing equipment and 400- and 600 grits of carbide discs in a moist atmosphere for 60 seconds at 200 rpm. To ensure dimensional consistency, a digital caliper (Mitutoyo Corp, Kawasaki, Japan) was employed to verify that all specimens maintained a thickness within 0.05 mm.23,24

Application of the thermocycling process

The specimens went through a simulated aging protocol, undergoing 5000 thermocycles in a thermocycling aging apparatus (Thermocycler THE-1100 machine; SD Mechatronik Feldkirchen, Westerham, Germany). Water baths ranging in temperature from 5°C to 55°C were used for the alternating cycles, with a 10-second interval between each bath and a 30-second immersion period. This simulation replicated the aging impact equivalent to six months of natural aging.2528

Application of flexural strength test

The flexural strength assessment was done using the universal testing machine (Instron 8871 Universal Testing Machine; Instron, Shakopee, MN, USA). A rounded-end steel indenter that was specially made with a 2.5-mm radius was employed. The crosshead speed was set at 1 mm/min, and an axial load of 30 N was directed vertically at the center of the ceramic specimens until fracture happened.29 The maximum load at the point of fracture was noted in Newtons for each specimen.25 Then, megapascals (MPa) were used to calculate the flexural strength based on recommendations outlined in the International Organization for Standardization’s (ISO) 6872 Dentistry—Ceramic Materials.30

Equations listed below were employed to compute the flexural strengths and elastic modulus of specimens.

Flexural strengthσ=3FL/2bh2
Where (b) is the tested specimen’s width, (h) is its thickness, (L) is the distance between the two supporting arms in mms, and (F) is the force applied till fracture in Newton.
Elastic modulusE=FL3/4bH3d
where (d) is the deflection measured at (F), and (F) is the load imposed on the linear section of the stress-strain curve (N).27

Scanning Electron Microscopy (SEM)

For surface qualitative evaluation via scanning electron microscopy (SEM), a randomly selected specimen from each subgroup was chosen to examine the topography of each sample following fracture. The SEM analysis was done using a scanning electron microscope (Inspect S50 model; FEI Company, Moravia, Czech Republic) operating at an increasing voltage of 20 KV and magnifications of ×10000. To reduce the impact of charging and enhance the clarity of the image, the specimens underwent a gold-coating process before examination.24

Statistical analysis

Plots (Q-Q plots and histograms), normality tests, and descriptive statistics were used to test for normality. All data showed normal distribution, so parametric analysis was adopted. Two factorial ANOVA models were performed to assess the association of different elements (type and thickness of tested ceramics) with flexural strength and elastic modulus. Calculations were done for adjusted means and 95% confidence intervals (CIs). P-value <0.05 was used as the significance threshold. Data analysis was done with Windows-based IBM SPSS (Version 26.0).

Result

Table 1 presents the flexural strengths and elastic moduli of the four studied ceramics at different thicknesses. At a thickness of 1.5 mm, ZLS exhibited the greatest flexural strength (mean (SD) = 309.08 (33.49)), while LE showed the most minor flexural strength (mean (SD)= 268.11 (7.48)).

Table 1. Comparison of flexural strengths and elastic moduli of the four studied ceramics at different thicknesses.

ALDZLSLDLE P value 1
Flexural strength (MPa)0.5 mm198.50 (74.59) A 223.38 (46.54) A 210.65 (27.16) A 191.23 (14.41) A 0.44
1 mm246.95 (48.23) B 275.99 (38.41) B 267.39 (37.71) B 231.45 (40.88) B 0.09
1.5 mm281.18 (39.51) ab, B 309.08 (33.49) a, B 301.96 (28.04) ab, B 268.11 (7.48) b, B 0.01*
P value 20.01* <0.001* <0.001* <0.001*
Force at break (N)0.5 mm90.51 (6.27) A 95.76 (31.19) A 91.79 (13.13) A 85.38 (8.51) A 0.63
1 mm230.00 (36.49) ab, B258.96 (52.27) a, B 251.41 (47.00) a, B 195.27 (9.73) b, B 0.005*
1.5 mm291.36 (67.42) a, C 416.56 (74.55) b, C 304.40 (85.99) a, B 204.04 (15.66) c, B <0.001*
P value 2<0.001* <0.001* <0.001* <0.001*
Young’s modulus of elasticity (GPa)0.5 mm22.25 (6.90) ab, A 29.51 (7.57) a, A 21.95 (7.07) ab, A 19.06 (4.72) b, A 0.009*
1 mm57.28 (16.35) B 52.11 (21.02) B 48.41 (13.80) B 59.65 (45.09) B 0.79
1.5 mm67.84 (13.81) ab, B 82.80 (12.35) a, C 67.31 (12.81) ab, C 64.07 (15.81) b, B 0.02*
P value 2<0.001* <0.001* <0.001* 0.002*

Moreover, at a 1.5 mm thickness, ZLS ceramic required the most significant amount of force to break (mean (SD) = 416.56 (74.55)) in contrast to the same thickness of LE, which required the least amount of force to be broken (mean (SD) = 204.04 (15.66)). Among the 1.5 mm thicknesses, ZLS had the highest Young’s modulus of elasticity (mean (SD) = 82.80 (12.35)), while LE had the lowest (mean (SD) = 82.80 (12.35)).

The 0.5mm thickness across all ceramic groups had the lowest flexural strength, elastic modulus, and forces to break. These values were significantly higher at 1.5 mm thickness when compared to 0.5- and 1-mm thicknesses, ZLS exhibiting the highest values (mean (SD) = 309.08 (33.49), 416.56 (74.55) and 82.80 (12.35)), respectively while the lowest values of 1.5 mm thickness were found among LE samples (mean (SD) = 268.11 (7.48), 204.04 (15.66) and 64.07 (15.81)).

Table 2 and Figure 2 illustrate the association of flexural strength with ceramic type and thickness. The findings indicated significant variations in flexural strength between the materials, with ZLS exhibiting the highest adjusted mean stress (269.49 MPa), followed by LD (260.00 MPa), ALD (242.21 MPa), and LE (230.26 MPa). Additionally, the materials’ thickness was a major factor, with the 1.5 mm thickness demonstrating the highest strength (290.08 MPa) and the 0.5 mm thickness presenting the least strength (205.94 MPa).

Table 2. Factorial ANOVA showing the association of flexural strength with ceramic type and thickness.

Flexural strength
Adjusted mean (SE)95% CI P value
Ceramic typeALD242.21 (7.03) a 228.29, 256.140.001*
ZLS269.49 (7.03) b 255.56, 283.41
LD260.00 (7.03) ab 246.08, 273.92
LE230.26 (7.03) a 216.34, 244.18
Thickness0.5205.94 (6.09) a 193.88, 218.00<0.001*
1255.45 (6.09) b 243.39, 267.50
1.5290.08 (6.09) c 278.03, 302.14
Model F (P value)23.07 (<0.001*)
Adjusted R20.48
0ecd6406-afeb-4393-9776-10cbeea3e73d_figure2.gif

Figure 2. Diagram showing the impact of ceramic type and thickness on flexural strength property.

SEM images at ×10000 magnification showed the crystalline structure of ALD, ZLS, LD, and LE specimens (Figure 3). ZLS showed a homogenous crystalline matrix (Figure 3a). At the same time, LD had needle-shaped fine-grained crystals within a glassy matrix (Figure 3b). LE and ALD images showed numerous pores with leucite crystals and lithium aluminum silicate crystals incorporated in a glassy matrix, respectively (Figure 3c and 3d).

0ecd6406-afeb-4393-9776-10cbeea3e73d_figure3.gif

Figure 3. SEM representing surface morphology of tested CAD/CAM ceramics at x10000 magnification where (a) ALD; Advanced lithium disilicate (b) ZLS; Zirconia lithium silicate, (c) LD; Lithium disilicate, (d) LE; Leucite reinforced.

Red arrows show the pores among specimens of ceramics.

Discussion

This study assessed the flexural strength of four CAD/CAM ceramic materials of varying thickness and compositions. The results showed that 1.5 mm thickness in the ZLS group was the highest flexural strength. Similar findings were noted in ZLS of 1.5 mm thicknesses in terms of elasticity. The highest strength was noticed among the ZLS specimens, LD, ALD, and LE, respectively, which subsequently required higher force to fracture. Specimens with a thickness of 1.5 mm exhibited significantly greater strength compared to the 0.5 mm samples, which presented the least strength. Thus, the null hypothesis is rejected.

Different thicknesses of ceramic material might yield varying flexural strength values on the ceramic materials. Ceramic materials of less thickness, such as 0.5 and 1mm, are suitable for minimally invasive procedures.31 Schweiger J et al.32 investigated three different types of CAD/CAM materials: LE, LD, and 3Y-TCP zirconia at five different thicknesses ranging from 0.4-1.6 mm. The lowest load required to fracture was recorded at the 0.4 mm thickness, while the highest load was required for the 1.6 mm thickness of zirconia, followed by LD and LE ceramics. This is consistent with the current study’s findings, where the 0.5 mm thickness of LE ceramics required the least force to fracture, while the 1.5 mm thickness of ZLS and LD required the highest force to fracture, respectively. The results of the flexural strength test of this study were compared to the readings of the biaxial flexural strength test described by Schweiger J et al.32 due to the lack of similar studies assessing the relation between varying ceramic thickness and the flexural strengths characteristic.

In assessing the relation between the ceramic composition of tested ceramics and flexural strength features, ZLS of all thicknesses exhibited the highest flexural strengths compared to LD and ALD, respectively. Meanwhile, LE ceramics exhibited the least flexural strengths among all tested materials at different thicknesses. This comes in agreement with Attar et al.33 findings, which reported that zirconia-reinforced lithium silicate ceramics (Vita suprinity) of 2 mm thickness exhibited higher flexural strengths than LD and LE, respectively. Similar findings were stated by Elsaka et al.34 after assessing the flexural strengths and elastic moduli of Vita suprinity and LD of 1.2 mm thickness. The higher strengths and elastic modulus of zirconia-reinforced ceramics are related to the presence of ZrO2 particles in the glassy matrix as in SEM images, resulting in a higher resistance to crack propagation.33,34 In contrast, Corade et al.35 showed increased flexural strength of LD specimens of 1.5 mm compared to both ZLS and other zirconia reinforced lithium disilicate ceramics of different manufacturers (Vita suprinity and Rosetta). This might refer to the different methods used in both studies.

The current results showed that LD reported higher flexural strength than ALD and LE ceramics. In agreement with these findings, another study reported that crystalized LD of 1 mm thickness exhibited higher flexural strength compared to ALD after exposure to different firing and glazing protocols.36 Similarly, another study displayed that the highest flexural strength was reported among LD specimens of 3 mm thickness contrasted to ALD.16 Furthermore, Sonmez et al.37 found that LD specimens of 1.2 mm thickness showed higher flexural strength than those of LE ceramics. These superior properties of LD might be due to the difference in composition, where LD includes a tiny amount of glass phase and lithium disilicate crystals, as shown in SEM.

Strengths of this study included assessing the flexural strengths of the most used CAD/CAM ceramics, varying in thicknesses relevant to fabricating different esthetic restorations such as dental veneers, veneered restorations, and all-ceramic prostheses. Moreover, a thermocycling procedure was applied to simulate an aging process equivalent to 6 months intraorally. Additionally, the study evaluated the flexural strengths and topography of Cerec tessera (ALD) ceramics, a type of ceramic that is relatively new in the CAD/CAM realm and has not been extensively studied in the literature, especially in variable thicknesses.

Despite the strengths, the study has several limitations; one major limitation is that it is an in vitro study, which may not fully represent the complex oral environment. Therefore, further clinical studies are required to assess different restoration designs and a wider range of dental materials to better simulate oral conditions. Moreover, the study only assessed low translucency ceramics, and future studies should consider evaluating different levels of translucency to understand their impact on flexural strengths more comprehensively. Further research is warranted to evaluate the impact of glazing on the mechanical properties of CAD/CAM ceramics following thermocycling-induced aging.

Conclusions

The increase in ceramic thickness significantly impacts flexural strength. A thickness of 1.5 mm was found to be optimum in restoring teeth in the posterior region or subjected to heavy occlusal load. Additionally, the composition of CAD/CAM ceramics has a crucial role in the flexural strength property. Dental ceramics, including zirconia fillers, are more resistant to deformation under masticatory loads than other glass ceramics. This was noted in ZLS ceramics. However, ALD requires further investigations to validate the current findings.

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Ellakany P, A. Al-Dulaijan Y, M. Aly N et al. Effect of thermocycling on flexural strength of dental CAD/CAM ceramics of variable thicknesses and structures: an in vitro study [version 3; peer review: 3 approved, 1 not approved]. F1000Research 2025, 13:1310 (https://doi.org/10.12688/f1000research.157128.3)
NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article.
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ApprovedThe paper is scientifically sound in its current form and only minor, if any, improvements are suggested
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Version 3
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Reviewer Report 05 Sep 2025
Gilan Altonbary, Department of Removable Prosthodontics, Faculty of Dentistry, Mansoura University, Mansoura, Egypt 
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I think that the authors have adequately addressed the comments made by ... Continue reading
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Altonbary G. Reviewer Report For: Effect of thermocycling on flexural strength of dental CAD/CAM ceramics of variable thicknesses and structures: an in vitro study [version 3; peer review: 3 approved, 1 not approved]. F1000Research 2025, 13:1310 (https://doi.org/10.5256/f1000research.185985.r405529)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
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Reviewer Report 04 Sep 2025
Rania Moussa, Department of Substitutive Dental Science, College of Dentistry, Taibah University, Madinah, Saudi Arabia 
Approved
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I would like to thank the authors for addressing the previous comments and making the necessary adjustments. The revisions have significantly improved the clarity and quality of the manuscript. I acknowledge the efforts made, and based on the current version, ... Continue reading
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Moussa R. Reviewer Report For: Effect of thermocycling on flexural strength of dental CAD/CAM ceramics of variable thicknesses and structures: an in vitro study [version 3; peer review: 3 approved, 1 not approved]. F1000Research 2025, 13:1310 (https://doi.org/10.5256/f1000research.185985.r405530)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
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Reviewer Report 25 Aug 2025
Amr Rizk, Prosthetic Dentistry, King Salman International University, El-Tur, South Sinai, Egypt 
Approved
VIEWS 4
I would like to thank the authors for enhancing the overall quality of the manuscript. Please put the following in consideration.
  1. The formula of lithium disilicate, the numbers should be in subscripts.
  2. It was
... Continue reading
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Rizk A. Reviewer Report For: Effect of thermocycling on flexural strength of dental CAD/CAM ceramics of variable thicknesses and structures: an in vitro study [version 3; peer review: 3 approved, 1 not approved]. F1000Research 2025, 13:1310 (https://doi.org/10.5256/f1000research.185985.r405531)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
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Reviewer Report 04 Aug 2025
Rania Moussa, Department of Substitutive Dental Science, College of Dentistry, Taibah University, Madinah, Saudi Arabia 
Approved with Reservations
VIEWS 7
Dear authors, Thank you for your efforts. The research addressed the impact of ceramic material composition in varying thicknesses on the flexural strength and elastic modulus.
This study is well-designed and addresses a significant question in restorative dentistry. It ... Continue reading
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Moussa R. Reviewer Report For: Effect of thermocycling on flexural strength of dental CAD/CAM ceramics of variable thicknesses and structures: an in vitro study [version 3; peer review: 3 approved, 1 not approved]. F1000Research 2025, 13:1310 (https://doi.org/10.5256/f1000research.183704.r395480)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
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Reviewer Report 28 Jul 2025
Amr Rizk, Prosthetic Dentistry, King Salman International University, El-Tur, South Sinai, Egypt 
Approved with Reservations
VIEWS 14
This manuscript entitled “Effect of thermocycling on flexural strength of dental CAD/CAM ceramics of variable thicknesses and structures: an in vitro study" aims to compare mechanical properties of glass ceramics of varying composition and thickness. The topic is relevant and ... Continue reading
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Rizk A. Reviewer Report For: Effect of thermocycling on flexural strength of dental CAD/CAM ceramics of variable thicknesses and structures: an in vitro study [version 3; peer review: 3 approved, 1 not approved]. F1000Research 2025, 13:1310 (https://doi.org/10.5256/f1000research.183704.r393621)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
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Reviewer Report 27 Mar 2025
Joissi Ferrari Zaniboni, São Paulo State University, São Paulo, Brazil 
Not Approved
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Dear Editor,
Thank you for inviting me to review the article. Count on me for the next ones.

The topic is relevant, especially because of the use of a material that has not been explored much ... Continue reading
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Zaniboni JF. Reviewer Report For: Effect of thermocycling on flexural strength of dental CAD/CAM ceramics of variable thicknesses and structures: an in vitro study [version 3; peer review: 3 approved, 1 not approved]. F1000Research 2025, 13:1310 (https://doi.org/10.5256/f1000research.172537.r352365)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
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Reviewer Report 10 Dec 2024
Gilan Altonbary, Department of Removable Prosthodontics, Faculty of Dentistry, Mansoura University, Mansoura, Egypt 
Approved
VIEWS 4
the authors are to be complimented for conducting this study. Its design is very good and materials and methods appropriate ,

 in the introduction section the authors mentioned that  research reporting the mechanical properties of ALD is ... Continue reading
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Altonbary G. Reviewer Report For: Effect of thermocycling on flexural strength of dental CAD/CAM ceramics of variable thicknesses and structures: an in vitro study [version 3; peer review: 3 approved, 1 not approved]. F1000Research 2025, 13:1310 (https://doi.org/10.5256/f1000research.172537.r339059)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.

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Approved with reservations - A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit.
Not approved - fundamental flaws in the paper seriously undermine the findings and conclusions
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