Keywords
Syphilis, prevalence, risk factors of syphilys in pregnancy, maternel and fetal prognosis.
Syphilis is a cosmopolitan infection, with recent infections (primary or secondary syphilis <1 year) posing the highest risk of mother-to-child transmission. In such cases, early treatment is crucial in determining obstetric prognosis.
This study aims to present current data and improve the management of syphilis in pregnant women in the city of Kisangani.
This is an analytical case-control study covering the period from July 1, 2023, to December 1, 2023. The study was conducted at Makiso Kisangani General Referral Hospital, with a study population of 976 pregnant women. A non-exhaustive sampling method was used, selecting a sample of 145 pregnant women diagnosed with syphilis and 145 others diagnosed with out syphilis. Data were analyzed using R software version 4.3.
The prevalence of syphilis during pregnancy was 16.9%. The most represented age group was 20 to 34 years (61.4%). The majority of pregnant women with syphilis were married (61.4%), in monogamous relationships (72.4%), and had unemployed partners (26.9%). The most common risk factors were having a partner who was a driver (OR: 3.31; p = 0.028), a trader (OR: 8.08; p <0.001), and having a history of STIs (p <0.001) or multiple sexual partners (p = 0.011). In 75% of cases, pregnancy resulted in the birth of a live fetus.
The prevalence of syphilis among pregnant women in the city of Kisangani is on the rise compared to previous years. Adverse pregnancy outcomes associated with syphilis could be reduced through early detection and standard treatment of syphilis for pregnant women and their husbands/sexual partners.
Syphilis, prevalence, risk factors of syphilys in pregnancy, maternel and fetal prognosis.
Syphilis is caused by Treponema pallidum. This sexually transmitted infection can also be transmitted vertically. If left untreated, syphilis can lead to complications during the second or third trimesters of pregnancy.1,2
La transmission verticale survient dans 50% des cas et conduit à beaucoup des complications. such as early fetal death, stillbirth, preterm birth, low birth weight, neonatal death, and congenital infection in infants.3,4
In 2016, maternal syphilis cases were estimated to have resulted in 143,000 early fetal deaths and stillbirths, 61,000 neonatal deaths, 41,000 preterm births or low birth weight cases, and 109,000 cases of clinical congenital syphilis.5
An infected and untreated mother can also transmit the disease to her child through transplacental transmission, which can occur as early as the 11th week of amenorrhea (WA) and is certain by the 16th WA, continuing throughout pregnancy. Transmission can also occur during delivery through contact with infected maternal secretions.6
The diagnosis of syphilis is simple and its treatment less expensive and not contraindicated during pregnancy. But syphilis in pregnant women is still an underestimated public health problem. According to the WHO, 2 million women are infected with syphilis worldwide and among untreated cases there are 65% of fetal complications.7,8
It is estimated that 2.7% of pregnant women in sub-Saharan Africa are infected with syphilis, representing more than 900,000 at-risk pregnancies each year.9
Despite the implementation of various guidelines to control sexually transmitted infections in the Democratic Republic of the Congo, the burden of syphilis persists. There are inconsistencies in the quality and utilization of services, which may be influenced by the knowledge of healthcare providers and pregnant women. Additionally, the prevalence of syphilis in urban and rural areas is different. Many factors such as diagnosis, treatment, frequency of visits, behavioral factors, sociodemographic and gyneco-obstetrical factors can change the burden of this desease.10–12
Moreover, data on syphilis in the Democratic Republic of the Congo, particularly in our study area, are scarce. Therefore, this study targets to determine the prevalence of syphilis in pregnant women and its associeted factors. in the city of Kisangani. The aim is to raise awareness among pregnant women about measures to prevent the adverse effects of this disease during pregnancy and to provide scientists with insights into the current syphilis rate and its most common complications among pregnant women in Kisangani.
To conduct this research, we asked the question:
What are the epidemiological aspects of syphilis among pregnant women in Kisangani?
Our study population consisted of all pregnant women who attended the prenatal consultation service at Makiso Kisangani General Referral Hospital (HGR) during the period from July 1, 2023, to December 1, 2023.
We tested a total of 976 pregnant women. Of the 165 syphilis-positive women, only 145 had been present until delivery. Another group of 145 syphilis-negative women were selected from the 811 syphilis-negative women. Our total sample size was therefore 290 pregnant women, of whom 145 were syphilis positive and 145 syphilis were negative.
For our study, we included:
• All pregnant women admitted to and/or followed up at HGR Makiso Kisangani during the study period;
• All pregnant women who attended at least four prenatal consultations (PNCs) during their pregnancy;
• All pregnant women diagnosed with syphilis during pregnancy confirmed by VDRL and TPHA tests;
• All pregnant women with a PNC record and a complete medical file;
• All pregnant women who consented to screening.
For data collection, screening tests were performed, and medical records of all consenting pregnant women who attended the PNC service and were followed until delivery at HGR Makiso Kisangani during the study period were reviewed. Data were collected using a pre-established data collection form, which included the following parameters:
Data entry was performed using Google Forms, and data analysis was conducted using R software version 4.3.
Results are presented in tables within means and standard deviations calculated for quantitative variables and frequencies and percentages calculated for qualitative variables Univariate logistic regression was used to calculate the odds ratio and to identify risk factors for syphilis during pregnancy.
The prevalence of syphilis in this study is calculated taking into account the total number of women who tested positive for syphilis, 165, compared to the total number of women tested, 976.
This study was approved by the Ethics Committee of the University of Kisangani, UNIKIS/CER/024/2023 on 7th of June 2023. This study was conducted in accordance with the requirements of good clinical practices and the principles of the Helsinki Declaration of the World Medical Association, along with any subsequent relevant amendments. Consent was obtained from the authorities of the participating institutions, and measures were taken to ensure that no information allowing patient identification was collected.
All participants have given their consent by signing the written document, the consent form.
The table below presents the cases of syphilis according to the sociodemographic characteristics of the pregnant women.
The most represented age group was between 20 and 34 years (61.4%). Married pregnant women in a monogamous relationship accounted for 72.4%. Housewives made up 22.1% of the study population, while women whose spouses were unemployed were also the most represented. Additionally, women with a secondary level of education constituted 46.2% (see Table 1 on page 5-6).
Table 2 shows that out of a total of 976 pregnant women who participated in our study, 165 were positive for syphilis during their pregnancies, i.e. a hospital prevalence of 16.9% (see Table 2 on page 6).
Prevalence | Number | Percentage |
---|---|---|
syphilis positive cases | 165 | 16.9 |
syphilis négative cases | 811 | 83.0 |
TOTAL | 976 | 99.9 |
Distribution of syphilis cases according to obstetrical
The table below presents syphilis cases by obstetric history.
It emerges from this table that: Pregnant women with a gestational age between 26 and 37 weeks were 59.3%; 62.1% of pregnant women with syphilis had a singleton pregnancy; 83.5% were multi-procedure, 75.9% of pregnant women with syphilis had given birth vaginally in the past (see Table 3 on page 6-7).
Distribution of syphilis cases according to others histories
The table below presents the cases of syphilis according to other histories.
It appears from this table that pregnant women with a notion of sexually transmitted infection were the most represented with a frequency of 53.1%. Pregnant women who had a history of syphilis were the most affected with a frequency of 40.3% (see Table 4 on page 7).
Distribution of syphilis cases according to syphilis treatment
The table below presents syphilis cases that received treatment for syphilis.
Syphilis treatment | Fréquency | Percentage |
---|---|---|
Yes | 96 | 66.2 |
No | 49 | 33.8 |
TOTAL | 145 | 100.0 |
It appears from this table that 66.2% of pregnant women had received anti-syphilitic treatment (see Table 5 on page 8).
The table below shows the outcome of the pregnancy and fetal prognosis according to the cases of syphilis
Pregnancy outcome | Number (N = 145) | Percentage |
---|---|---|
Abortion | 29 | 20.0 |
MIU | 29 | 20.0 |
Premature birth | 37 | 25.5 |
Full-terme delivery | 50 | 34.4 |
Abortion type | Number (N = 29) | Percentage |
---|---|---|
Early | 11 | 37.9 |
Late | 18 | 62.1 |
Fetal pronosis | Number (N = 116) | Percentage |
---|---|---|
In live | 87 | 75 |
Died | 29 | 25 |
It emerges from this table that 50 pregnancies or 34.4% ended in a full-term delivery. It appears from this table that 18 abortions, or 62.1%, were late. 75% of pregnancies ended in a live fetus (see Table 6 on page 8).
Sociodemographic characteristics
The table below presents the risk factors according to sociodemographic characteristics.
Some of the husband’s occupation, certaines places of residence and the level of education are risk factors in our study. Women whose spouses were drivers, shopkeepers, students, and unemployed were more likely to contract syphilis than those whose spouses were teachers. Women who lived in Mangobo commune and those who resided in Tshopo commune were more likely to develop syphilis Women with primary education were 2.76 times more likely to develop syphilis than women with university education (see Table 7 on page 8-9).
Antécédents
Women with a history of STIs were 2.97 times more likely to develop. Women who were on ARV treatment were 1.92 times more likely to develop syphilis. Pregnant women who had more than one sexual partner were 1.88 times more likely to develop syphilis (see Table 8 on page 10).
Our study proves that the rate of syphilis among pregnant women in the city of Kisangani is on the rise. This may be explained by the increasing population in Kisangani in recent years, the decrease in awareness campaigns encouraging women to seek adequate treatment in case of STIs, and also the reluctance of some patients to consult a healthcare professional when experiencing STI symptoms.
The prevalence of syphilis among the study participants was 16.9%;
Our results are higher than those found by Katenga B. et al.,13 who reported a prevalence of 10.9% in Kisangani in 2014.
According to Table 7, it emerges that:
• Pregnant women whose partners were drivers, merchants, students, and unemployed were at a higher risk of developing syphilis compared to those whose partners were teachers;
• Pregnant women residing in the communes of Mangobo and Tshopo were more likely to develop syphilis compared to those living in the Makiso commune;
• Pregnant women with a primary level of education were 2.76 times more likely to develop syphilis compared to those with secondary or university education.
Our findings are consistent with those of Katenga B. et al.,13 who found that having a partner who is a merchant was a risk factor for developing syphilis. Similarly, Meng Zhang et al.14 in China identified a primary level of education as a risk factor.
Considering the poverty in our community, merchants, drivers, and students are more likely to attract women and may have multiple sexual partners without using protective measures against STIs.
Pregnant women with a primary level of education lack sufficient knowledge about STIs, their prevention, and protection measures.
Table 8 indicates that having a history of STIs, receiving ARV treatment, and having multiple sexual partners were risk factors for developing syphilis among our pregnant women.
Our findings align with those of Jacob S et al.15 in Zambia, who confirmed that a history of STIs, multiple sexual partners, and HIV were significantly associated with maternal syphilis.
M. Tardieu et al.16 in France also found that a history of STIs and multiple sexual partners were the most frequently reported risk behaviors among pregnant women with syphilis.
Our findings could be explained by the fact that prevention and protection measures against STIs are not yet fully accepted and implemented in our communities due to certain religious and cultural beliefs that often oppose the use of some protective methods, such as condoms.
Our results showed that 75% of pregnancies in pregnant women with syphilis resulted in the birth of a live fetus.
Our results are lower than those found by Moraes et al.17 in Brazil, where 86.5% of pregnancies had a favorable outcome and 13.5% had unfavorable outcomes. Similarly, Carles G. et al.18 in French Guiana reported a 20% fetal mortality rate.
This could be explained by the fact that, according to Fatima LUBUELA in the DRC,19 80% of pregnant women start prenatal consultations late. Consequently, the detection and management of various pathologies occur late, increasing the risk of adverse pregnancy outcomes in case of complications.
Based on observations made during our study, our findings align with the conclusions drawn by this author.
Age
We found that the most affected age group was between 20 and 34 years old (61.4%),
Our result is close to that found by Cyprin K. et al.20 in Cameroon (68%).
This could be explained by the fact that, according to Roger T. et al.21 in the DRC, "84% of young girls have their first sexual intercourse at an average age of 15.98 years, and it is often unprotected." They are therefore not well informed about STI prevention and protection measures and have more time to develop such infections.
Marital status
The distribution of pregnant women by marital status shows a predominance of married women (61.4%) in our setting.
Cyprien K. et al.20 in Cameroon and Nacer et al.22 in Morocco found that 80.3% and 96.9%, respectively, of married women or those living in cohabitation were affected by syphilis.
Our results can be explained by the fact that in our setting, the majority of pregnant women are married or living in cohabitation.
Occupation
Our study found that the majority of pregnant women with syphilis were housewives (22.1%).
Our results are similar to those found by Cyprien K. et al.20 in Cameroon (49.4%) and those of Sangu K. et al.23 in Benin, who made similar observations.
This could be explained by the fact that housewives are more numerous in the general population and are less informed about STIs and their prevention and protection measures, making them more vulnerable to contracting STIs.
Partner’s occupation
We observed that pregnant women whose partners were unemployed were the most affected (26.9%).
Kelah Z. et al.24 in Tanzania observed a predominance of pregnant women whose partners were employed in the private sector.
This could be explained by the fact that 80% of the population in the DRC is unemployed, according to the summary of the book “Instruments of Economic Policy and the Fight Against Unemployment in the DRC.” As a result, they do not always have the financial means to acquire protection against STIs.
Educational level
In our study, we observed a high frequency of syphilis among pregnant women with a secondary level of education (46.2%).
Cyprien K. et al.20 in Cameroon found that 43.0% of pregnant women with secondary education were affected by syphilis.
According to the secondary analysis of EDS-RDC, “educated women are more likely to engage in high-risk sexual behavior than uneducated women.”
However, based on our observations, our study does not align with this analysis, as pregnant women with a moderate level of education are more affected by syphilis in our setting.
• Conception and implementation: All authors
• Financial support: All authors
• Administrative support: All authors
• Provision of study material or patients: All authors
• Data collection and assembly: All authors
• Data analysis and interpretation: All authors
• Manuscript writing: All authors
• Final manuscript approval: All authors
• Responsible for all aspects of the work: All authors
The authors are employees of the University of Kisangani and the University of Mbujimayi.
This study received approval from the ethics committee of the University of Kisangani on UNIKIS/CER/024/2023 of 7th June 2023. It was conducted in accordance with the requirements of good clinical practices and the principles of the Helsinki Declaration of the World Medical Association, along with any subsequent relevant amendments. All women who have participated in this study have provided their consent by signing a written document.
The participants also gave their consent for their data to be published. Our data collection was done anonymously. We have taken all measures not to publish any data that could facilitate the identification of participants.
• The prevalence of syphilis among pregnant women was 16.9%.
• This prevalence is higher than previous studies.
• This prevalence indicates the progression of this pathology in our setting.
• The risk factors were having a partner who is a driver, trader, student, or unemployed.
• Others risk factors were primary education level, history of STIs, ARV treatment, and multiple sexual partners.
• The maternal-fetal prognosis was favorable, with 75% of pregnancies resulting in live births.
• This shows the importance of diagnosing and treating syphilis in pregnant women.
• Targeted education for at-risk groups, such as drivers, shopkeepers, students, and people with multiple partners.
• Integrate syphilis testing into antenatal care to identify and treat infected pregnant women.
• Ensure the availability of penicillin, the treatment of choice for syphilis, in all health centres.
• Establish protocols to screen and treat newborns at risk of congenital syphilis.
• Improved data collection to better monitor prevalence and assess the effectiveness of interventions.
Figshare: Syphilis in pregnancy: prevalence, risk factors and maternal-fetal prognosis in Kisangani. Doi: https://doi.org/10.6084/m9.figshare.28292933.v2.25
This project contains the following underlying data:
Data.xlsx [anonymised results of microscopic syphlis in pregnancy, Marital status (Married=1, Single =2),occupation (unemployed=1, State agent=2, Houde keeper=3, Private sector=4, trader=5, student=6), Adress (Makiso=1, Mangobo=2, Tshopo=3, Kabondo=4, Kisangani=5, Lubunga=6), Educational level (Elementary school=1, High school=2, university= 3), socio-economic level (low=1, Middle=2, high=3), Type of marriage (Monogamic=1, Polygamic=2), Type of pregnancy (Monofœtale=1,Gémellaire=2, Multiple=3), Route of past delivery (vaginnaly=1, cesarean=2), concept of STI (yes=1, No=2) ARV treatment (yes=1, No=2)].
Data are available under the terms of the Creative Commons Attribution 4.0 International license (CC-BY 4.0).
We would like to thank Makiso General Referral Hospital Authorities for allowing us to carry out this study in their establishment.
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Is the work clearly and accurately presented and does it cite the current literature?
Partly
Is the study design appropriate and is the work technically sound?
Partly
Are sufficient details of methods and analysis provided to allow replication by others?
Partly
If applicable, is the statistical analysis and its interpretation appropriate?
Partly
Are all the source data underlying the results available to ensure full reproducibility?
Yes
Are the conclusions drawn adequately supported by the results?
Partly
Competing Interests: No competing interests were disclosed.
Reviewer Expertise: Epidemiology, Syphilis, Sexually Transmitted Infections, Clinical Trials
Is the work clearly and accurately presented and does it cite the current literature?
Partly
Is the study design appropriate and is the work technically sound?
Yes
Are sufficient details of methods and analysis provided to allow replication by others?
No
If applicable, is the statistical analysis and its interpretation appropriate?
Partly
Are all the source data underlying the results available to ensure full reproducibility?
No
Are the conclusions drawn adequately supported by the results?
Partly
Competing Interests: No competing interests were disclosed.
Reviewer Expertise: Epidemiology, infectious diseases, syphilis, STIs
Alongside their report, reviewers assign a status to the article:
Invited Reviewers | ||
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Version 1 25 Feb 25 |
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