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Research Article
Revised

Analysis of the peristaltic flow of a variable viscosity Carreau fluid affected by temperature and concentration through an endoscope hollow flexible channel

[version 2; peer review: 1 approved, 2 approved with reservations, 1 not approved]
PUBLISHED 02 Mar 2026
Author details Author details
OPEN PEER REVIEW
REVIEWER STATUS

This article is included in the Fallujah Multidisciplinary Science and Innovation gateway.

Abstract

Background

Peristaltic or undulating flow plays a significant role in various biomedical and industrial processes, where it provides an efficient mechanism for transporting fluids through flexible conduits such as catheters and endoscopic channels. Understanding such flow behavior is essential for improving medical devices and industrial applications involving non-Newtonian fluids.

Methods

This study investigates the peristaltic motion of a Carreau fluid whose viscosity varies with both temperature and concentration within a flexible, axisymmetric channel composed of two overlapping cylindrical tubes. The outer wall of the channel exhibits a sinusoidal wave pattern, simulating a realistic endoscopic configuration. The governing nonlinear, nonhomogeneous partial differential equations were formulated in cylindrical coordinates under the assumption of a long wavelength and low Reynolds number. The equations were transformed into a dimensionless form and solved using the uniform perturbation method. Graphical analyses were performed using Mathematica software.

Results

The results illustrate the combined effects of temperature-dependent and concentration-dependent viscosity on the velocity distribution and pressure gradient within the channel. Increasing temperature and solute concentration were found to enhance fluid velocity and reduce flow resistance.

Conclusions

The study provides a comprehensive understanding of peristaltic transport in variable-viscosity Carreau fluids under realistic physiological conditions. These findings may contribute to optimizing the design and performance of endoscopic and biomedical fluid transport systems.

Keywords

Viscous Carreau fluid, peristaltic flow, endoscopic hollow flexible channel.

Revised Amendments from Version 1

In this revised version of the article, several substantive improvements have been made compared to the previously published version. The Introduction has been revised to enhance clarity and coherence, and additional recent references have been incorporated to strengthen the theoretical background. In Section 4, a new equation has been introduced to further support the analytical framework of the study. The figures have been updated for improved accuracy and presentation, with additional symbols included where necessary. Moreover, the interpretations of the figures have been refined to provide clearer explanations and more precise discussion of the results. These revisions improve the overall rigor, clarity, and scientific contribution of the manuscript.

See the authors' detailed response to the review by Ahmed Gamal
See the authors' detailed response to the review by Anum Tanveer
See the authors' detailed response to the review by Shekar Marudappa
See the authors' detailed response to the review by P. Lakshminarayana Lakshminarayana

1. Introduction

Peristaltic transport is a fundamental mechanism of fluid motion generated by progressive wave-like contractions of flexible channel walls. This mechanism plays a crucial role in many physiological processes, including blood circulation, gastrointestinal motility, urine transport, and the operation of catheter- and endoscope-based medical devices. In addition to biomedical applications, peristaltic transport is widely utilized in industrial processes involving complex fluids, particularly in situations where direct mechanical pumping is undesirable or impractical.

Most biological and industrial fluids exhibit non-Newtonian behavior, making classical Newtonian fluid models inadequate for realistic flow prediction. Among the various rheological models, the Carreau fluid model has received considerable attention due to its ability to accurately represent shear-thinning behavior and viscosity variation with shear rate. This feature makes it especially suitable for modeling physiological fluids such as blood. Several studies have investigated peristaltic transport under the Carreau fluid assumption. Ali and Hayat7 analyzed pumping characteristics, axial pressure gradients, and trapping phenomena, providing a comparative study between Newtonian and Carreau fluids. Nadeem et al.11 examined peristaltic wave propagation of Carreau fluid in a rectangular duct under the assumptions of long wavelength and low Reynolds number. Ullah et al.16 studied Carreau fluid flow in an elastic tube, emphasizing the significant role of wall flexibility. In addition, peristaltic transport of other non-Newtonian fluids, such as Jeffrey fluid, in flexible channels has been reported by Al-Khalidi and Al-Khafajy,6 highlighting the importance of rheological complexity in peristaltic flow modeling.

Viscosity is one of the most influential physical properties governing fluid motion, particularly in biomedical and food-processing applications. In realistic physiological environments, viscosity is not constant but depends strongly on temperature and concentration variations, which significantly affect flow behavior, heat transfer, and mass diffusion. Several researchers have reported that although fluid velocity exhibits relatively small variations with concentration and spatial location, it increases noticeably with increasing temperature.1,5,10,12 Nadeem et al.9 investigated peristaltic flow of a reactive viscous fluid with temperature-dependent viscosity. Akram and Akbar2 analyzed biological flow of a Carreau nanofluid in an endoscopic system incorporating variable viscosity effects. The influence of temperature and concentration on oscillatory flow in an inclined porous channel was studied by Al-Khafajy and Labban,4 while Al-Delfi and Al-Khafajy3 examined peristaltic transport of Williamson fluid through a hollow flexible channel, accounting for coupled thermal and concentration effects.

Recent developments in peristaltic flow research have emphasized the necessity of incorporating multiple physical mechanisms to achieve realistic modeling of physiological and industrial transport processes. These mechanisms include heat transfer, mass diffusion, nanofluid effects, magnetohydrodynamics (MHD), electroosmosis, and complex wave motions in flexible biomedical geometries. In this context, Tanveer et al.13 investigated flow and heat transfer characteristics in a fallopian tube with a metachronal wave of cilia, demonstrating the crucial role of coordinated wall motion in physiological transport. Tanveer et al.14 further explored dynamic interactions in MHD Jeffrey fluid flow under peristalsis combined with electroosmotic effects and homogeneous–heterogeneous chemical reactions, highlighting the strong coupling between electromagnetic forces, chemical reactions, and non-Newtonian rheology. Moreover, Tanveer et al.15 analyzed the enhancement of heat generation using a ternary hybrid nanofluid in a periodic channel, reflecting the growing interest in advanced nanofluid models for thermal management applications.

Furthermore, Vijayan and Sucharitha17 examined electroosmotic effects on peristaltic transport of a Ree–Eyring nanofluid with double diffusive convection in a symmetric microchannel, demonstrating the strong interaction between electric fields, thermal gradients, and concentration gradients on flow behavior. Jagadesh et al.8 studied convective peristaltic pumping of an MHD Ree–Eyring nanofluid in a chemically reacting flexible divergent channel, incorporating the effects of activation energy and thermal radiation. Their findings emphasize the importance of coupling electromagnetic, chemical, and thermal effects with non-Newtonian rheology in advanced peristaltic flow models.

These studies collectively indicate that realistic modeling of physiological and industrial transport processes requires the simultaneous consideration of thermal effects, concentration gradients, non-Newtonian fluid behavior, and geometrical features such as wall flexibility and internal devices. Despite these extensive efforts, the combined influence of temperature- and concentration-dependent viscosity on the peristaltic flow of a Carreau fluid through a flexible axisymmetric wavy channel containing an internal catheter has not yet been adequately investigated. In particular, the interaction between variable viscosity, channel flexibility, and internal catheter geometry remains insufficiently explored, despite its direct relevance to catheter-based and endoscopic medical applications.

Motivated by this research gap, the present study develops a mathematical model for the peristaltic transport of an incompressible, non-Newtonian Carreau fluid with variable viscosity flowing through a flexible axisymmetric wavy channel containing an internal catheter placed along the centerline. The effects of temperature and concentration variations at the channel walls are incorporated into the viscosity formulation. Under the assumptions of long wavelength and low Reynolds number, the governing equations are simplified and solved analytically. Unlike earlier investigations that considered either constant viscosity or rigid geometries, the present model simultaneously accounts for variable viscosity, wall flexibility, and internal catheter effects, thereby providing a more comprehensive and physiologically realistic representation of peristaltic transport phenomena.

2. Mathematical formulation

We study the peristaltic flow of an incompressible Carreau fluid between two cylinders that are in a central location, with an endoscope in the middle of the main channel that has a flexible wall structured like a sine wave. A cylinder’s coordinates are specified by the radius of the channel (R) and the tube’s axis (Z).

The geometry wall of the flow channel form is

r¯=r1¯(z¯,t¯)=a1,r¯=r2¯(z¯,t¯)=a2+bsin(2πγ(z¯ct¯))

Here “the unobstructed radius of the pipe” is represented by a1 , the radius of the disturbed tube is represented by a2 , b is “amplitude of the peristaltic wave”, γ is “a wave length”, c is “a wave propagation speed”, and t¯ is “a time”.

The basic governing equations of the problem system

(1)
.U¯=0(continuity equation)
(2)
ρ(U.¯)U¯=σ´+ρgβ1(TT0)+ρgβ2(0)(momentum equation)
(3)
Tp.ρ(U.¯)T=K.2T.QrQ(TT0)(temperature equation)
(4)
(U.¯¯)=Dn2+DnKTTn2T(concentration equation)

Where 2=1rr(rr) “Laplace operator”, U¯=(U¯1,0,U¯3) is “the velocity field”, ρ is a “density”, σ´ is “the Cauchy stress tensor”, T is “the temperature”, is a concentration of the fluid, Tp is “the specific heat capacity at constant pressure”, Qr is “the radiation heat flux”, Dn is “the coefficient of mass diffusivity”, Tn is “the mean fluid temperature”, KT is “the thermal diffusion ratio”.

The equation of incompressible Carreau fluid with variable viscosity as the distance travelled is given by7

(5)
σ´=P¯I¯+S¯,
(6)
S¯=μ(T)[1+(n12)Γ2α̇¯2]α̇¯

Where S¯ is “extra stress tensor”, P¯ "pressure", I¯ “identity tensor”, μ “dynamic viscosity”, Γ “time constant”, n “dimensionless power law index” and α̇ is defined as;

(7)
α̇=12i=13j=13α̇ijα̇ji

The model can be reduced to a Newtonian model n=1orΓ=0 , so we investigate the case for Γ0 . To understand how an elastic wall behaves, the equation L=P¯p¯0 , where L is “an operator”, which is used to represent the motion of stretched membrane with viscosity damping forces such that, see3

L=B4Z¯42Z¯2+m2t¯2+Dt¯+AL

Wall flexural rigidity is denoted by B, longitudinal tension per unit width by , mass per unit area by m, coefficient of viscous damping by D, and spring stiffness by AL .

This is the equation that controls the properties of a flexible wall canal at r¯=r2¯ , is obtained as;

(8)
P¯Z¯=Z¯(B4Z¯42Z¯2+m2t¯2+Dt¯+AL)(r2¯)

3. Simplified Governing Equations

For the sake of accuracy in writing the continuity equation and the momentum equations, in addition to the temperature and concentration equations, we use the velocity components U1¯(R¯,Z¯,t¯) and U3¯(R¯,Z¯,t¯) , which represent the radial and axial velocity components, respectively, in an unsteady two-dimensional flow. The fluid temperature and concentration functions are expressed in terms of T=T(R¯,Z¯,t¯) and =(R¯,Z¯,t¯) , respectively. Now, by substituting the governing equations for the problem (1) - (4), we obtain the following system of nonlinear, nonhomogeneous partial differential equations;

(9)
U1¯R¯+U1¯R¯+U3¯Z¯=0
(10)
ρ(U1¯t¯+U1¯U1¯R¯+U3¯U1¯Z¯)=p¯R¯+1R¯R¯(R¯S¯R¯R¯)+S¯R¯Z¯Z¯
(11)
ρ(U3¯t¯+U1¯U3¯R¯+U3¯U3¯Z¯)=p¯Z¯+1R¯R¯(R¯S¯Z¯R¯)+S¯Z¯Z¯Z¯+ρgβ1(TT0)+ρgβ2(0)
(12)
Tt¯+U1¯TR¯+U3¯TZ¯=TnTpρ(1R¯TR¯+2TR¯2+2TZ¯2)+16σ0T2E3k0Tpρ(1R¯TR¯+2TR¯2)qTpρ(TT0)
(13)
t¯+U1¯R¯+U3¯Z¯=Dn(1R¯R¯+2R¯2+2Z¯2)+DnKTTn(1R¯TR¯+2TR¯2+2TZ¯2)

The component S¯R¯Z¯ of the shear stress is

S¯R¯Z¯=μ(T){1+(n12)Γ2(2[(U1¯R¯)2+(U1¯R¯)2+(U3¯Z¯)2]+[(U1¯Z¯+U3¯R¯)2])}(U1¯Z¯+U3¯R¯)

We use generic and specific frame coordinate transformations as shown below. U1¯=u1¯ , U3¯=u3¯+c , R¯=r¯ , and Z¯=z¯ . Substituting these transformations into a system (9) - (13), we get:

(14)
u1¯r¯+u1¯r¯+(u3¯+c)z¯=0
(15)
ρ(u1¯t¯+u1¯u1¯r¯+(u3¯+c)u1¯z¯)=p¯r¯+1r¯r¯(r¯S¯r¯r¯)+S¯r¯z¯z¯
(16)
ρ((u3¯+c)t¯+u1¯(u3¯+c)r¯+(u3¯+c)(u3¯+c)z¯)=p¯z¯+1r¯r¯(r¯S¯r¯z¯)+S¯z¯z¯z¯+ρgβ1(TT0)+ρgβ2(0)
(17)
Tt¯+u1¯Tr¯+(u3¯+c)Tz¯=TnTpρ(1r¯Tr¯+2Tr¯2+2Tz¯2)+16σ0T2E3k0Tpρ(1r¯Tr¯+2Tr¯2)qTpρ(TT0)
(18)
t¯+u1¯r¯+(u3¯+c)z¯=Dn(1r¯r¯+2r¯2+2z¯2)+DnKTTn(1r¯Tr¯+2Tr¯2+2Tz¯2)

The corresponding boundary conditions of the problem are:

(19)
u1¯=0,u3¯+c=0,T=T0,=1atr¯=r1¯=a1u1¯=0,u3¯+c=0,T=T1,=0atr¯=r2¯=a2+bsin(2πγ(z¯ct¯))}

Where the motion equation with condition of the elastic wall as follows:

(20)
z¯(B4Z¯4C2Z¯2+m2t¯2+Dt¯+AL)(r2¯)=p¯z¯=ρ((u3¯+c)t¯+u1¯(u3¯+c)r¯+(u3¯+c)(u3¯+c)z¯)+1r¯r¯(r¯S¯r¯z¯)+S¯z¯z¯z¯+ρgβ1(TT0)+ρgβ2(0)

To simplify the governing equations of the problem and to show the important parameters that affect the fluid flow, we introduce the following dimensionless transformations2,10:

(21)
u1=u1¯γa2c,u3=u3¯c,r=r¯a2,z=z¯γ,S=a2S¯μvc,p=a22p¯μv,φ=ba2,t=ct¯γ,r2=r2¯a2,r1=r1¯a2,a1a2=ε<1,Ω=qa22μvTp,δ=a2γ,Re=ρca2μv,Pr=μvTpTn,M(H)=μ(T)μv,We=Γca2,α̇=a2α̇¯c,Rn=K0μTp4T2Eσ0,H=TT0T1T0,ξ=010,G1=ρgβ1a22(T0T1)μvs,G2=ρgβ2a22(C1C0)μvs,S1=ρDnKT(T1T0)μvTn(C1C0),S2=μvρDn}

where φ “amplitude ratio”, Re “Reynolds number”, Pr “Prandtl number”, Rn “thermal radiation parameter”, S2 “Schmidt number”, S1 “Soret number”, G1 “thermal Grashof number”, G2 “Solutal Grashof number”, δ “dimensionless wave number”, Ω “heat source/sink parameter”, and We is the Weissenberg number, μv “viscosity constant”.

Substituting Equations (21) into Eqs. (14) - (20), we reformulate the governing equations and accompanying boundary conditions as follows:

(22)
(cγ)(u1r+u1r+u3z)=0
(23)
Reδ3(u1t+u1u1r+(u3+1)u1z)=pr+δ1rr(rSrr)+δ2Srzz
(24)
Reδ(u3t+u1u3r+(u3+1)u3z)=pz+1rr(rSrr)+δSzzz+G2ξ+G1H
(25)
Reδ(Ht+u1Hr+(u3+1)Hz)=1Pr(1rHr+2Hr2+δ22Hz2)+43Rn(1rHr+2Hr2)ΩH
(26)
Reδ(ξt+u1ξr+(u3+1)ξz)=1S2(1rξr+2ξr2+δ22ξz2)+S1(1rHr+2Hr2+δ22Hz2)

The component Srz of the shear stress in dimensionless transformation form is

(27)
Srz=M(H){1+(n12)We2(2δ2[(u1r)2+(u1r)2+(u3z)2]+[(δ2u1z+u3r)2])}(δ2a2u1z+u3r)

The corresponding dimensionless boundary conditions of the problem are

(28)
u1=0,u3=1,H=0,ξ=1atr=r1=εu1=0,u3=1,H=1,ξ=0atr=r2=1+φsin(2π(zt))}
(29)
(e15z5e23z3+e33∂z∂t2+e42∂z∂t+e5∂z)r2=1rr(rSrz)+δSzzzReδ(u3t+u1u3r+(u3+1)u3z)+G2ξ+G1H
where e1=Ba23μvcγ5 is the flexural stiffness of the wall, e2=Ca23μvcγ3 is the longitudinal tension per unit width, e3=mca23μvγ3 is the mass per unit area, e4=Da23μvγ2 is the coefficient of viscid damping, and e4=ALa23μv is spring stiffness, respectively.

These parameters are selected within physically realistic ranges commonly reported in the literature on peristaltic flow through elastic or compliant channels.3,5 They represent the resistance of the wall to bending and stretching, its inertia, viscous damping, and elastic support, respectively. The chosen values ensure numerical stability and allow a clear illustration of the essential physical behavior of the system. Moreover, it has been observed that moderate variations in these parameters do not significantly affect the qualitative trends of the results; therefore, a representative set of parameter values is employed throughout the analysis.

It is very difficult to solve the system of Equations (22) - (27) and (29), so we assume a very small wave number ( δ ≪ 1) concerning the width of the channel to its length. Thus, the system becomes in the following form after abbreviating its writing, taking into account the condition of the flexibility of the outer wall of the flow channel:

(30)
(e15z5e23z3+e33∂z∂t2+e42∂z∂t+e5∂z)r2=1rr(rSrz)+G2ξ+G1H
(31)
(1Pr+43Rn)(2Hr2+1rHr)ΩH=0
(32)
1S2(2ξr2+1rξr)+S1(2Hr2+1rHr)=0
with
(33)
Srz=M(μ){1+(n12)We2(u3r)2}(u3r)

4. Solution method

This section involves solving the heat and concentration equations, then substituting the result into the velocity equation to solve it.

4.1 Temperature and concentration function

The solution to the equations for heat fluid (31) and concentration fluid (32) based on the boundary condition Equation (28) are respectively:

H=J[0,iAr]B1+Y[0,iAr]B2,ξ=B4+B3log[r]+Σ(1+I[0,Ar2]B1)A+Σ(Y[0,iAr])B2A.

where =Ω(1Pr+43Rn) , Σ=S1S2A , and

B1=Y[0,iAε]/(J[0,iAε]Y[0,iAh]+J[0,iAh]Y[0,iAε]),B2=J[0,iAε]/(J[0,iAε]Y[0,iAh]J[0,iAh]Y[0,iAε]).B3=1A((Log[h]Log[ε])(A+ΣI[0,Ah2]B1ΣI[0,Aε2]B1+ΣY[0,iAh]B2ΣY[0,iAε]B2),B4=1A(Log[h]Log[ε])(ALog[h]ΣLog[h]B1+ΣI[0,Aε2]Log[h]B1+ΣLog[ε]B1ΣI[0,Ah2]Log[ε]B1+ΣY[0,iAε]Log[h]B2ΣY[0,iAh]Log[ε]B2).

4.3 Velocity function

The formula for the velocity equation under the influence of the elasticity of the outer wall of the flow channel, after substituting the shear stress equation in Equation (30), is

(34)
(e15z5e23z3+e33∂z∂t2+e42∂z∂t+e5∂z)r2=G2ξ+G1H+1rr(rM(H){1+(n12)We2(u3r)2}(u3r))

For the variable viscosity M(H) , we use Reynolds’ model of viscosity M(H)=eαH . By using the Maclaurin series, we have M(H)=1αH when α1 , where α is the coefficient of variable viscosity, the viscosity is fixed at α=0 . Thus, the final form of the velocity equation will be

(35)
(e15z5e23z3+e33∂z∂t2+e42∂z∂t+e5∂z)r2=G2ξ+G1H+1rr(r(1αH){1+(n12)We2(u3r)2}(u3r))

Equation (35) is a non-linear and non-homogeneous partial differential equation, which is difficult to find an exact solution for it, so the perturbation method (twice in terms of We parameter first, then in terms of the α parameter) will be used to find the solution to the problem, as follows:

let

(36)
u3=u30+We2u31+OWe4

After substitution (36) into Equation (35), we get:

(37)
1ru30+We2u31r+n12We2u30+We2u31r31rαHu30+We2u31r1rαHn12We2u30+We2u31r3+2u30+We2u31r2+3n12We2u30+We2u31r22u30+We2u31r2αH2u30+We2u31r2+3n12We2u30+We2u31r22u30+We2u31r2αHru30+We2u31r+n12We2u30+We2u31r3=e15z5e23z3+e33zt2+e42zt+e5zr2G2ξG1H

4.3.1 Zero order system ( We0 )

(38)
(e15z5e23z3+e33zt2+e42zt+e5z)r2G2ξG1H=1ru30r1rαHu30r+2u30r2αH2u30r2αHr(u30r)

Substation with an equation perturbation

(39)
u30=u300+αu301+Oα2

After substitution (39) into Equation (38), we get:

(40)
e15z5e23z3+e33zt2+e42zt+e5zr2G2ξG1H=1ru300+αu301r1rαHu300+αu301r+2u300+αu301r2αH2u300+αu301r2αHru300+αu301r
  • (i) Zero order system ( α0)

(e15z5e23z3+e33zt2+e42zt+e5z)r2G2ξG1H=1ru300r+2u300r2

The associated boundary conditions u300(r1)=u300(r2)=1 .

  • (ii) First order system ( α )

2u301r2+1ru301r=H(1ru300r+2u300r2)Hr(u300r)

The associated boundary conditions u301(r1)=u301(r2)=0 .

4.3.2 Second order system ( We2 )

(41)
Ο=1ru31r+1r(n12)(u30r)31rαH(n12)(u30r)31rαHu31r+2u31r2+3(n12)(u30r)2(2u30r2)αH2u31r23αH(n12)(u30r)2(2u30r2)αHr(u31r)αHr(n12)(u30r)3

Substation with an equation perturbation

(42)
u31=u310+αu311+Oα2

After substitution (42) into Equation (41), we get:

Ο=1ru310+αu311r+1rn12u300r3+3αu300r2u301r1rαHn12u300r3+3αu300r2u301r1rαHu310+αu311r+2u310+αu311r2+3n12u300r22u300r2+2αu300ru301r2u300r2+αu300r22u301r2αH2u310+αu311r23αHn12
(43)
u300r22u300r2+2αu300ru301r2u300r2+αu300r22u301r2αHru310+αu311rαHrn12u300r3+3αu300r2u301r
  • (i) Zero order system ( α0)

2u310r2+1ru310r=1r(n12)(u300r)33(n12)(u300r)2(2u300r2)

The associated boundary conditions u320(r1)=u320(r2)=0 .

  • (ii) First order system ( α )

2u311r2+1ru311r=H(2u310r2+1ru310r)+3(1n2)(1r(u301r)+(2u301r2))(u300r)23(n1)(u300r)(u301r)(2u300r2)+(n12)H(3(2u300r2)(u300r)2+1r(u300r)3)Hr[(n12)(u300r)3+(u301r)]

The associated boundary conditions u321(r1)=u321(r2)=0 .

We obtain very long solutions for the velocity and stream function, known as u3=1rψr , that mean ψ=r((u300+αu301)+We2(u320+αu321))dr . The associated constants can be determined using the associated boundary conditions. Therefore, we will discuss these solutions graphically in the next section.

5. Solution analysis

Through the graphs of the fluid velocity function, we discussed and analysed the effect of changing temperature on the viscosity of a Carreau fluid and thus on its velocity through a hollow flexible channel. The program “MATHEMATICA 14” was used in this analysis. The following values were adopted to plot the fluid velocity function: e1=0.3 , e2=0.7 , e3=0.5 , e4=0.5 , e5=0.2 , Ω=0.5 , G1=2 , G2=1 , S1=0.7 , S2=0.3 , Rn=0.5 , Pr=1.7 , ε=0.2 , φ=0.15 , We=0.2 , α=0.1 , n=0.3 .

The general shape of the fluid velocity function is a downward-concave curve where the maximum value of the curve is close to the catheter tube around the value of r=0.3 , also the ends of the curve are close to zero at the walls of the channel (the rigid inner and the flexible outer), which matches the boundary condition of the problem.

d1ad8952-b3da-465c-987b-804b326ccf5b_figure1.gif

Figure 1. The problem ometry.

d1ad8952-b3da-465c-987b-804b326ccf5b_figure2.gif

Figure 2. e1 , e2 Increasing these parameters enhances wall elasticity, which facilitates the fluid motion and increases the velocity.

d1ad8952-b3da-465c-987b-804b326ccf5b_figure3.gif

Figure 3. e3 and e4 These elasticity parameters resist fluid motion, reducing the velocity.

d1ad8952-b3da-465c-987b-804b326ccf5b_figure4.gif

Figure 4. e5 This parameter positively affects wall motion, resulting in higher fluid velocity, Ω Heat absorption or sink reduces thermal energy in the fluid, decreasing velocity.

d1ad8952-b3da-465c-987b-804b326ccf5b_figure5.gif

Figure 5. G1 , G2 Higher thermal and solutal Grashof numbers enhance buoyancy-driven flow, increasing the velocity.

d1ad8952-b3da-465c-987b-804b326ccf5b_figure6.gif

Figure 6. S1 , and S2 Increased Soret and Schmidt effects strengthen mass transfer-driven flow, boosting velocity.

d1ad8952-b3da-465c-987b-804b326ccf5b_figure7.gif

Figure 7. Rn and Pr Higher thermal radiation and Prandtl number reduce thermal diffusion and increase viscous effects, slowing down the fluid.

d1ad8952-b3da-465c-987b-804b326ccf5b_figure8.gif

Figure 8. φ Larger wall wave amplitude enhances peristaltic pumping, increasing fluid velocity, ε increasing tube radius increases flow resistance near the walls, reducing velocity.

d1ad8952-b3da-465c-987b-804b326ccf5b_figure9.gif

Figure 9. We and α Higher Weissenberg number and perturbation parameter strengthen the fluid’s elastic and oscillatory response, increasing velocity.

d1ad8952-b3da-465c-987b-804b326ccf5b_figure10.gif

Figure 10. We notice that the fluid temperature decreases with increasing Prandtl number Pr ​ and tube radius ratio ε .

Higher Pr ​ reduces thermal diffusivity, limiting heat penetration into the fluid, while larger ε, increases wall surface effects, enhancing heat transfer toward the walls and lowering the core temperature.

d1ad8952-b3da-465c-987b-804b326ccf5b_figure11.gif

Figure 11. The fluid temperature decreases with increasing Ω and Rn , as higher Ω, absorbs heat and larger Rn ​ enhances radiative heat loss.

d1ad8952-b3da-465c-987b-804b326ccf5b_figure12.gif

Figure 12. The fluid temperature increases with amplitude ratio φ and time t, as higher φ enhances wall-induced mixing and higher t, allows heat to diffuse and accumulate within the fluid.

d1ad8952-b3da-465c-987b-804b326ccf5b_figure13.gif

Figure 13. The fluid concentration decreases with increasing φ and t, as larger wall amplitude enhances mixing and longer time allows diffusion to reduce concentration locally.

d1ad8952-b3da-465c-987b-804b326ccf5b_figure14.gif

Figure 14. The fluid concentration increases with increasing S1,andS2 ​, as higher Soret and Schmidt numbers strengthen mass transfer effects, promoting solute accumulation.

d1ad8952-b3da-465c-987b-804b326ccf5b_figure15.gif

Figure 15. The fluid concentration increases with increasing Rn and Ω, as higher thermal radiation and heat source parameters enhance energy transfer, supporting solute accumulation.

d1ad8952-b3da-465c-987b-804b326ccf5b_figure16.gif

Figure 16. Increasing e1 ​ enhances wall deformation, allowing larger boluses to form.

d1ad8952-b3da-465c-987b-804b326ccf5b_figure17.gif

Figure 17. Increasing e2 similarly increases wall motion, leading to larger trapped boluses.

d1ad8952-b3da-465c-987b-804b326ccf5b_figure18.gif

Figure 18. Increasing ​ e3 resists wall motion, reducing the size of the trapped boluses.

d1ad8952-b3da-465c-987b-804b326ccf5b_figure19.gif

Figure 19. Higher solutal Grashof number G2 ​ increases buoyancy effects, expanding the bolus size.

d1ad8952-b3da-465c-987b-804b326ccf5b_figure20.gif

Figure 20. Increasing the catheter tube radius ε reduces flow resistance, allowing the boluses to expand.

d1ad8952-b3da-465c-987b-804b326ccf5b_figure21.gif

Figure 21. Larger wall wave φ amplitude enhances peristaltic pumping, increasing the trapped bolus size.

d1ad8952-b3da-465c-987b-804b326ccf5b_figure22.gif

Figure 22. Higher Weissenberg number We strengthens elastic effects, enlarging the boluses.

d1ad8952-b3da-465c-987b-804b326ccf5b_figure23.gif

Figure 23. Increasing the perturbation parameter α enhances oscillatory motion, increasing bolus size.

6. Conclusions and Summary

Here we will go over the main points that affect the flow of an incompressible Carreau fluid via a flexible endoscopic hollow tube. Utilizing the perturbation method in conjunction with the MATHEMATICA-14 program, we ascertained the velocity function. We visually examined all the results that came from changing different relevant settings. The key points may be summarized as follows:

  • 1- There is a positive correlation between the growth of e1,e2,We,φ,e5,α , G1,G2,S1,andS2 while decreases the velocity is due to the increase in parameter e3,e4 , ε,Pr,Rn and Ω .

  • 2- The trapped bolus expands with an increase e1,e2,We,φ,andε, the trapped bolus shrinks increasing the values of α,e3.

  • 3- The following parameters S1 , S1 , Pr , Rn , Ω , G1 , e5 ,ande4 , have no effect on the stream function.

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Al-Tamimi Skk and Al-Khafajy DGS. Analysis of the peristaltic flow of a variable viscosity Carreau fluid affected by temperature and concentration through an endoscope hollow flexible channel [version 2; peer review: 1 approved, 2 approved with reservations, 1 not approved]. F1000Research 2026, 15:18 (https://doi.org/10.12688/f1000research.172584.2)
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ApprovedThe paper is scientifically sound in its current form and only minor, if any, improvements are suggested
Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit.
Not approvedFundamental flaws in the paper seriously undermine the findings and conclusions
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PUBLISHED 02 Mar 2026
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Reviewer Report 10 Mar 2026
Shekar Marudappa, B. M. S. College of Engineering, Bengaluru, Karnataka, India 
Approved
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No ... Continue reading
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Marudappa S. Reviewer Report For: Analysis of the peristaltic flow of a variable viscosity Carreau fluid affected by temperature and concentration through an endoscope hollow flexible channel [version 2; peer review: 1 approved, 2 approved with reservations, 1 not approved]. F1000Research 2026, 15:18 (https://doi.org/10.5256/f1000research.196535.r463588)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
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Reviewer Report 04 Mar 2026
Ahmed Gamal, Menoufia University, Shebin El-Kom, Egypt 
Not Approved
VIEWS 12
Dear Authors,
Thank you for submitting the revised version of your manuscript and for providing detailed responses to the previous review comments. The manuscript shows improvements in structure, expanded literature coverage, and clearer figure presentation.
However, after ... Continue reading
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Gamal A. Reviewer Report For: Analysis of the peristaltic flow of a variable viscosity Carreau fluid affected by temperature and concentration through an endoscope hollow flexible channel [version 2; peer review: 1 approved, 2 approved with reservations, 1 not approved]. F1000Research 2026, 15:18 (https://doi.org/10.5256/f1000research.196535.r463590)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
Version 1
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PUBLISHED 07 Jan 2026
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Reviewer Report 23 Jan 2026
Shekar Marudappa, B. M. S. College of Engineering, Bengaluru, Karnataka, India 
Not Approved
VIEWS 21
The research article titled "Analysis of the peristaltic flow of a variable viscosity Carreau fluid affected by temperature and concentration through an endoscope hollow flexible channel”. In its current form the paper is "not recommended for indexing".

... Continue reading
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Marudappa S. Reviewer Report For: Analysis of the peristaltic flow of a variable viscosity Carreau fluid affected by temperature and concentration through an endoscope hollow flexible channel [version 2; peer review: 1 approved, 2 approved with reservations, 1 not approved]. F1000Research 2026, 15:18 (https://doi.org/10.5256/f1000research.190322.r448707)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
  • Author Response 02 Mar 2026
    Salwa Al-Tamimi, Department of Fluid Mechanics, University of Al-Qadisiya, AL-Qadisiya, 58001, Iraq
    02 Mar 2026
    Author Response
    We sincerely thank the reviewer for the detailed and constructive comments. We greatly appreciate the time and effort taken to provide feedback, which has significantly helped improve the clarity, scientific ... Continue reading
COMMENTS ON THIS REPORT
  • Author Response 02 Mar 2026
    Salwa Al-Tamimi, Department of Fluid Mechanics, University of Al-Qadisiya, AL-Qadisiya, 58001, Iraq
    02 Mar 2026
    Author Response
    We sincerely thank the reviewer for the detailed and constructive comments. We greatly appreciate the time and effort taken to provide feedback, which has significantly helped improve the clarity, scientific ... Continue reading
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Reviewer Report 23 Jan 2026
P. Lakshminarayana Lakshminarayana, Vellore Institute of Technology, Vellore, Tamil Nadu, India 
Approved with Reservations
VIEWS 28
This study investigates the peristaltic flow of a variable-viscosity Carreau fluid through a hollow, flexible endoscopic channel under the combined effects of temperature and concentration variations. The analysis highlights the influence of non-Newtonian behaviour on the channel's transport characteristics.
... Continue reading
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Lakshminarayana PL. Reviewer Report For: Analysis of the peristaltic flow of a variable viscosity Carreau fluid affected by temperature and concentration through an endoscope hollow flexible channel [version 2; peer review: 1 approved, 2 approved with reservations, 1 not approved]. F1000Research 2026, 15:18 (https://doi.org/10.5256/f1000research.190322.r448710)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
  • Author Response 02 Mar 2026
    Salwa Al-Tamimi, Department of Fluid Mechanics, University of Al-Qadisiya, AL-Qadisiya, 58001, Iraq
    02 Mar 2026
    Author Response
    We sincerely thank the reviewer for the detailed and constructive comments, which have significantly helped improve the scientific quality, clarity, and presentation of the manuscript. All points raised have been ... Continue reading
COMMENTS ON THIS REPORT
  • Author Response 02 Mar 2026
    Salwa Al-Tamimi, Department of Fluid Mechanics, University of Al-Qadisiya, AL-Qadisiya, 58001, Iraq
    02 Mar 2026
    Author Response
    We sincerely thank the reviewer for the detailed and constructive comments, which have significantly helped improve the scientific quality, clarity, and presentation of the manuscript. All points raised have been ... Continue reading
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Reviewer Report 22 Jan 2026
Anum Tanveer, Mirpur University of Science and Technology (MUST), Mirpur, Pakistan 
Approved with Reservations
VIEWS 24
Review Report
The abstract presents a well-structured and coherent study on the peristaltic flow of a variable-viscosity Carreau fluid in a flexible, axisymmetric channel with biomedical relevance. The background clearly establishes the importance of peristaltic transport in medical ... Continue reading
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Tanveer A. Reviewer Report For: Analysis of the peristaltic flow of a variable viscosity Carreau fluid affected by temperature and concentration through an endoscope hollow flexible channel [version 2; peer review: 1 approved, 2 approved with reservations, 1 not approved]. F1000Research 2026, 15:18 (https://doi.org/10.5256/f1000research.190322.r448711)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
  • Author Response 02 Mar 2026
    Salwa Al-Tamimi, Department of Fluid Mechanics, University of Al-Qadisiya, AL-Qadisiya, 58001, Iraq
    02 Mar 2026
    Author Response
    We sincerely thank the reviewer for the constructive comments and valuable suggestions, which have significantly helped us to improve the quality and clarity of the manuscript. All comments have been ... Continue reading
COMMENTS ON THIS REPORT
  • Author Response 02 Mar 2026
    Salwa Al-Tamimi, Department of Fluid Mechanics, University of Al-Qadisiya, AL-Qadisiya, 58001, Iraq
    02 Mar 2026
    Author Response
    We sincerely thank the reviewer for the constructive comments and valuable suggestions, which have significantly helped us to improve the quality and clarity of the manuscript. All comments have been ... Continue reading
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23
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Reviewer Report 20 Jan 2026
Ahmed Gamal, Menoufia University, Shebin El-Kom, Egypt 
Not Approved
VIEWS 23
 Summary of the Article
The manuscript investigates peristaltic transport of a non-Newtonian fluid under various physical effects using analytical approximations. While the topic itself falls within an active research area, the present study does not demonstrate sufficient originality, methodological ... Continue reading
CITE
CITE
HOW TO CITE THIS REPORT
Gamal A. Reviewer Report For: Analysis of the peristaltic flow of a variable viscosity Carreau fluid affected by temperature and concentration through an endoscope hollow flexible channel [version 2; peer review: 1 approved, 2 approved with reservations, 1 not approved]. F1000Research 2026, 15:18 (https://doi.org/10.5256/f1000research.190322.r448712)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
  • Author Response 02 Mar 2026
    Salwa Al-Tamimi, Department of Fluid Mechanics, University of Al-Qadisiya, AL-Qadisiya, 58001, Iraq
    02 Mar 2026
    Author Response
    We sincerely thank the reviewer for the constructive and valuable comments, which have greatly contributed to improving the scientific quality and clarity of the manuscript. All raised issues have been ... Continue reading
COMMENTS ON THIS REPORT
  • Author Response 02 Mar 2026
    Salwa Al-Tamimi, Department of Fluid Mechanics, University of Al-Qadisiya, AL-Qadisiya, 58001, Iraq
    02 Mar 2026
    Author Response
    We sincerely thank the reviewer for the constructive and valuable comments, which have greatly contributed to improving the scientific quality and clarity of the manuscript. All raised issues have been ... Continue reading

Comments on this article Comments (0)

Version 2
VERSION 2 PUBLISHED 07 Jan 2026
Comment
Alongside their report, reviewers assign a status to the article:
Approved - the paper is scientifically sound in its current form and only minor, if any, improvements are suggested
Approved with reservations - A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit.
Not approved - fundamental flaws in the paper seriously undermine the findings and conclusions
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