ALL Metrics
-
Views
-
Downloads
Get PDF
Get XML
Cite
Export
Track
Case Report

Case Report: Non-infectious causes of palmoplantar rashes, what to consider

[version 1; peer review: 2 approved, 1 approved with reservations]
PUBLISHED 11 Jan 2018
Author details Author details
OPEN PEER REVIEW
REVIEWER STATUS

Abstract

Background: Palm and sole skin eruptions have a broad differential diagnosis. It is particularly important to recognize common causes as well as their association with certain chemotherapy regimens such as Capecitabine.
Case report: A 79-year-old woman presented with a painful rash on her hands and feet for 1 week. She had metastatic colon cancer and was in her third week of treatment with capecitabine. Her diagnosis was a medication side-effect from chemotherapy. Capecitabine was stopped and she had some clinical improvement over the next two days. She was discharged with oncology follow up for resumption of Capecitabine at a lower dose with improvement in her rash 3 weeks later.

Discussion: Skin rashes are a commonly encountered complaint in patients in the inpatient and outpatient setting. It is important to maintain a broad differential diagnosis in those with rashes of the palmoplantar surfaces of the hands and feet. Recognizing skin changes as a possible manifestation of underlying malignancy or a medication side-effect is key in appropriate diagnosis and treatment.

Keywords

Palmoplantar skin rash, Medication side-effect, capecitabine

Introduction

Palmoplantar skin eruption is a commonly encountered diagnosis in the inpatient and outpatient setting. Most likely causes include Type IV hypersensitivity reactions (i.e. contact dermatitis), tinea pedis/manuum, psoriasis, and dyshidrotic dermatitis. These rashes may also be associated with underlying malignancies, especially gastrointestinal malignancies or can be associated with a medication side-effect1. Palmoplantar erythrodysesthesia (PPE), also known as hand-foot syndrome is a toxic, cutaneous side effect of well-associated chemotherapeutic agents, especially capecitabine24. The pathophysiology of this condition is not well understood and is an active area of investigation. It is important to recognize this side effect early in patients treated with oral capecitabine chemotherapy and to differentiate it from similar presentations in other disease entities. We present a case of a woman on chemotherapy for metastatic colon cancer with a palmoplantar rash.

Case report

A 79- year-old Hispanic woman presented with a one-week history of painful rash on her palms and soles. She reported no recent viral illness, travel, previous rashes, joint pains, new lotion, soap or fabric use. She had metastatic colon cancer previously treated with radiation and hemicolectomy three years prior. She currently completed her second week of Capecitabine therapy (1,250mg/m2 twice a day). She had no other contributory medical history or family history and was on no other medications. She describes never having a similar rash in the past.

On physical exam, she was afebrile, normotensive and appeared chronically ill. Her palms and soles were tender to touch, erythematous, and diffusely edematous with desquamation over the fingertips and toes (Figure 1 and Figure 2). Biochemical testing including complete metabolic panel and complete blood count were normal. Given her recently administered chemotherapy, it was suspected that the patients’ palmoplantar rash was a result of a medication side-effect from Capecitabine. Other less likely diagnoses were contact dermatitis, tinea pedia/mannum, or dyshidrotic dermatitis.

84de0f58-3eed-44af-b6a4-b664af12448c_figure1.gif

Figure 1. Erythema, swelling, and desquamation of the palmar surfaces.

84de0f58-3eed-44af-b6a4-b664af12448c_figure2.gif

Figure 2. Erythema, swelling, and desquamation of the plantar surfaces.

After Capecitabine was stopped, she had mild clinical improvement over the next two days. She was discharged with resumption of Capecitabine at a lower dose (565 mg/m2 twice daily) and had complete clinical resolution of her rash 3 week later.

Discussion

Palmoplantar skin eruption carries a varied differential diagnosis. Common causes include contact dermatitis, tinea pedis/manuum, psoriasis, dyshidrotic dermatitis and palmoplantar pustulosis. Other palmoplantar rashes such as palmoplantar keratoderma (PPK), Acanthosis Nigricans (AN), Tripe palm, and Acquired Ichthyosis are also associated with underlying malignancies5,6. PPK presents with a yellow, wax-like hyperkeratosis of the palms and soles. AN, seen in patients with insulin resistance, presents as palmoplantar plaques which can be a sign of internal gastric cancer6. Tripe palm, also associated with gastric and lung malignancies, presents with wrinkled velvety hyperkeratosis of the palmoplantar surfaces7. Lastly, acquired ichthyosis is a symmetric scaling of the skin, associated with Hodgkins lymphoma8.

Since our patient had a temporal relationship between initiation of a new medication and her presentation, it was likely related, if not the cause of her palmoplantar rash. Chemotherapy, such as Capecitabine, is an important cause of palmoplantar skin eruption known as palmoplantar erythrodysesthesia (PPE). It is characterized by pain, swelling and desquamation, which can progress to ulceration and blistering (Figure 1 and Figure 2). In total, 7% of patients treated with Capecitabine may experience PPE. Other commonly encountered chemotherapy regimens may also cause PPE, such as Cytarabine, Fluorouracil, and Doxorubicin. Treatments include either withdrawal of the chemotherapy or dose reduction, and supportive measures. In our patient’s case, we were limited by not being able to completely stop chemotherapy given her limited therapeutic options; however resuming treatment at a lower dose helped to resolve her symptoms as well as provide a longer life-expectancy.

Common diagnoses aside, medication side-effect and malignancy should be considered in the differential diagnosis of palmoplantar skin eruption to guide appropriate therapy.

Consent

Written informed consent was obtained from the patient for the publication of the patient’s clinical details and accompanying images.

Comments on this article Comments (0)

Version 1
VERSION 1 PUBLISHED 11 Jan 2018
Comment
Author details Author details
Competing interests
Grant information
Copyright
Download
 
Export To
metrics
Views Downloads
F1000Research - -
PubMed Central
Data from PMC are received and updated monthly.
- -
Citations
CITE
how to cite this article
Advani R and Arad D. Case Report: Non-infectious causes of palmoplantar rashes, what to consider [version 1; peer review: 2 approved, 1 approved with reservations]. F1000Research 2018, 7:46 (https://doi.org/10.12688/f1000research.13513.1)
NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article.
track
receive updates on this article
Track an article to receive email alerts on any updates to this article.

Open Peer Review

Current Reviewer Status: ?
Key to Reviewer Statuses VIEW
ApprovedThe paper is scientifically sound in its current form and only minor, if any, improvements are suggested
Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit.
Not approvedFundamental flaws in the paper seriously undermine the findings and conclusions
Version 1
VERSION 1
PUBLISHED 11 Jan 2018
Views
3
Cite
Reviewer Report 05 Mar 2018
Regina Fölster-Holst, Dermatologische Klinik, Universität Kiel, Kiel, Germany 
Approved
VIEWS 3
The authors describe a 79-year old woman presented with palmoplantar rash. This was characterized by painful erythema, edema and desquamation. In this case the history led to the right diagnosis: the woman suffered from metastatic colon cancer and underwent chemotherapy ... Continue reading
CITE
CITE
HOW TO CITE THIS REPORT
Fölster-Holst R. Reviewer Report For: Case Report: Non-infectious causes of palmoplantar rashes, what to consider [version 1; peer review: 2 approved, 1 approved with reservations]. F1000Research 2018, 7:46 (https://doi.org/10.5256/f1000research.14673.r30832)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
Views
9
Cite
Reviewer Report 27 Feb 2018
Mohamed Badawy Abdel-Naser, Department of Dermatology and Venereology, Ain Shams University Hospital, Cairo, Egypt 
Approved
VIEWS 9
The case report is well written.
 
The title is not addressing the case. Perhaps it can be reformulated to directly refer to the case.
 
The statement "however resuming treatment at a lower dose helped to ... Continue reading
CITE
CITE
HOW TO CITE THIS REPORT
Abdel-Naser MB. Reviewer Report For: Case Report: Non-infectious causes of palmoplantar rashes, what to consider [version 1; peer review: 2 approved, 1 approved with reservations]. F1000Research 2018, 7:46 (https://doi.org/10.5256/f1000research.14673.r30831)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.
Views
8
Cite
Reviewer Report 21 Feb 2018
Sidharth Sonthalia, Department of Dermatology & Dermatosurgery, Skinnocence: The Skin Clinic & Research Center, Gurgaon, India 
Approved with Reservations
VIEWS 8
  1. The title could have been better - "Non-infectious causes of palmoplantar rashes, what to consider" would have been more apt in a case where there was diagnostic confusion based on history and/or examination. In this case, the
... Continue reading
CITE
CITE
HOW TO CITE THIS REPORT
Sonthalia S. Reviewer Report For: Case Report: Non-infectious causes of palmoplantar rashes, what to consider [version 1; peer review: 2 approved, 1 approved with reservations]. F1000Research 2018, 7:46 (https://doi.org/10.5256/f1000research.14673.r30835)
NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article.

Comments on this article Comments (0)

Version 1
VERSION 1 PUBLISHED 11 Jan 2018
Comment
Alongside their report, reviewers assign a status to the article:
Approved - the paper is scientifically sound in its current form and only minor, if any, improvements are suggested
Approved with reservations - A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit.
Not approved - fundamental flaws in the paper seriously undermine the findings and conclusions
Sign In
If you've forgotten your password, please enter your email address below and we'll send you instructions on how to reset your password.

The email address should be the one you originally registered with F1000.

Email address not valid, please try again

You registered with F1000 via Google, so we cannot reset your password.

To sign in, please click here.

If you still need help with your Google account password, please click here.

You registered with F1000 via Facebook, so we cannot reset your password.

To sign in, please click here.

If you still need help with your Facebook account password, please click here.

Code not correct, please try again
Email us for further assistance.
Server error, please try again.