<p>A mechanistic neural network model optimizing both the potency and toxicity of combination therapies</p>

Harkirat Singh Arora; Katherine Lev; Aaron Robida; Sriram Chandrasekaran

doi:10.7490/f1000research.1120056.1

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Arora HS, Lev K, Robida A and Chandrasekaran S. A mechanistic neural network model optimizing both the potency and toxicity of combination therapies [version 1; not peer reviewed]. F1000Research 2024, 13:1514 (poster) (https://doi.org/10.7490/f1000research.1120056.1)

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A mechanistic neural network model optimizing both the potency and toxicity of combination therapies

Harkirat Singh Arora, Katherine Lev, Aaron Robida, Sriram Chandrasekaran¹

Published 12 Dec 2024 (https://doi.org/10.7490/f1000research.1120056.1)

Author Affiliations

¹ Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA

Copyright © 2024 Arora HS et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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CITE

Published 12 Dec 2024

A mechanistic neural network model optimizing both the potency and toxicity of combination therapies
[version 1; not peer reviewed]

Harkirat Singh Arora, Katherine Lev, Aaron Robida, Sriram Chandrasekaran¹

Author Affiliations

¹ Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA

Presented at

Intelligent Systems for Molecular Biology Conference (ISMB), 2025

Competing Interests

No competing interests were disclosed

Keywords

Machine learning, Drug discovery, Antibiotic resistance, Combination therapies, Neural networks, Metabolic models

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