Effects of exercise on thyroid hormones in children and adolescents with thyroid function disorders: A Systematic Review

Bindya Rajashekar; Vijay Pratap Singh; Namrata Singh Chauhan

doi:10.12688/f1000research.109949.1

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Systematic Review

Effects of exercise on thyroid hormones in children and adolescents with thyroid function disorders: A Systematic Review

[version 1; peer review: 1 approved, 1 approved with reservations]

Bindya Rajashekar¹, Vijay Pratap Singh ¹, Namrata Singh Chauhan¹

PUBLISHED 15 Mar 2022

Author details Author details

¹ Department of Physiotherapy, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India, Mangalore, India

Bindya Rajashekar
Roles: Conceptualization, Data Curation, Formal Analysis, Funding Acquisition, Investigation, Methodology, Project Administration, Resources, Software, Supervision, Validation, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing

Vijay Pratap Singh
Roles: Conceptualization, Data Curation, Formal Analysis, Funding Acquisition, Investigation, Methodology, Project Administration, Resources, Software, Supervision, Validation, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing

Namrata Singh Chauhan
Roles: Funding Acquisition, Investigation, Methodology, Project Administration, Resources, Software, Supervision, Validation, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing

OPEN PEER REVIEW

REVIEWER STATUS

This article is included in the Manipal Academy of Higher Education gateway.

Abstract

Background: Exercise leads to changes in hormonal concentration and metabolites which impacts growth and development; during physical activity, energy metabolism is influenced by hormones associated with pubertal development, and characterization of its response to exercise is essential. Therefore, we aimed to identify the effects of exercise on thyroid hormones in children and adolescents with thyroid function disorders.
Methods: A comprehensive literature search was performed in PubMed, Scopus, Web of Science, CINAHL, and Embase based on the search strategy, and the articles were screened based on inclusion criteria, for which two independent reviewers conducted data extraction. The eligible studies were methodologically assessed using a modified Downs and Black’s checklist. The extracted data were summarized according to study population, intervention, type and duration, outcome measures, and results.
Results: The total number of screened articles was 1,710, out of which six papers were included for review. Studies included children and adolescents with hypothyroidism, intellectual disabilities, and obesity who received exercise or physical activity as an intervention. The outcomes included thyroid hormones T3, T4, and TSH. Studies were generally of low quality. The findings of the studies throw some light on the benefits of exercise or physical activity.
Conclusions: Structured physical activity and exercise followed for a more extended period showed some thyroid function changes in this population. The intensity of change was directly proportional to exercise intensity. However, this review does not provide sufficient evidence stating that exercise results in changes of thyroid function returning to normal, which requires further higher-quality studies to strengthen the review’s findings.

Keywords

Adolescent, Children, Thyroid function disorders, Thyroid hormones, Exercise training, Physical activity

Corresponding author: Vijay Pratap Singh

Competing interests: No competing interests were disclosed.

Grant information: The author(s) declared that no grants were involved in supporting this work.

Copyright: © 2022 Rajashekar B et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

How to cite: Rajashekar B, Singh VP and Singh Chauhan N. Effects of exercise on thyroid hormones in children and adolescents with thyroid function disorders: A Systematic Review [version 1; peer review: 1 approved, 1 approved with reservations]. F1000Research 2022, 11:313 (https://doi.org/10.12688/f1000research.109949.1) First published: 15 Mar 2022, 11:313 (https://doi.org/10.12688/f1000research.109949.1) Latest published: 15 Mar 2022, 11:313 (https://doi.org/10.12688/f1000research.109949.1)

Introduction

Thyroid hormones play an important role in early neurocognitive development, growth, and tissue maturation throughout childhood and adolescence.¹^,² Normal thyroid function is essential for regulating metabolic processes such as molecular mechanism, lipid regulation, thermogenesis, and adrenergic stimulation, and thus control energy balance by regulation, storage, and expenditure.³^–⁵ Energy expenditure and body weight also correlate with hormonal status. The metabolic pathway regulation involves a direct pathway with bile acid stimulation, and an indirect pathway with nuclear receptors leading to lipolysis and lipogenesis.⁴^,⁵ Thyrotropin-releasing hormone (TRH) from the hypothalamus acts upon the pituitary gland, which increases cAMP and subsequent thyrotropin release. These hormonal signals modulate Thyroid-stimulating hormone (TSH) secretion. Thyroid hormone synthesis and secretion involve the functioning of the hypothalamic-pituitary-thyroid (HPT) axis through a negative feedback mechanism that regulates thyroid functions by converting T4 to T3, which leads to a decrease in TRH and TSH secretion in response to adequate thyroid hormone levels in tissues.²^,⁶^,⁷

Thyroid function disorders are evaluated based on clinical presentation, thyroid function tests revealing levels of serum TSH, freeT4-thyroxine, and freeT3-thyroid thyroxine.⁴^,⁵ Hormonal status with hyperthyroidism corresponds with excess thyroid hormones showing as weight loss, reduced cholesterol level, increased lipolysis, and gluconeogenesis. On the other hand, hypothyroidism is presented with low plasma levels of thyroid hormones, showing as a hypometabolic state with increased cholesterol levels leading to weight gain.⁵

Functions of thyroid hormones also include regulation of indirect effects of cardiac functions, due to hemodynamic changes by thyroid hormones leading to its dysfunction. At the tissue level, thyroid hormones influence the function of brown and white adipose tissue. Increased fat accumulation alters the normal functioning of the hypothalamic-pituitary-thyroid axis, leading to changes in thyroid function. The pathophysiology of thyroid axis dysfunction is not yet fully understood.⁴^,⁶ Hypotheses have been proposed indicating that thyroid dysfunction is a consequence of excess body weight rather than its cause.⁸^–¹¹ In developing children, thyroid hormones and function are essential for brain cell growth and differentiation, and induce neurotransmitter function. Their deficiency in foetal life and early infancy impairs neurocognitive function, which is irreversible, causing retarded brain maturation and intellectual deficits. Congenital hypothyroidism shows an incidence of 1 in 1,500 to 3,000 newborns, most commonly due to thyroid dysgenesis, which is followed by abnormal thyroid hormonal levels due to the defects in thyroid hormone biosynthesis or secretion.¹²^,¹³

Thyroid hormones at the skeletal muscle level influence plasma glucose levels, increasing carbohydrate metabolism and reducing white adipose tissue level, corresponding to increased mitochondrial activity due to thyroid hormone levels.¹⁴ The human body undergoes various modifications to adapt to stress. The endocrine system also undergoes numerous changes when subjected to stress under physical exercise to maintain hormonal balance and normal metabolic processes.³^,¹⁵^,¹⁶ Regular physical activity and training have been shown to suppress proinflammatory cytokine production and enhance fibrinolytic activity to improve the chronic inflammatory conditions post-exercise at the muscle level. Additionally, overtraining leads to changes in the central nervous system (CNS) activation of hypothalamic nuclei, influencing Adrenocorticotropic hormone (ACTH) and cortisol release accounting for behavioral changes. It also regulates the effects of thermogenesis and substrate metabolism when excess physical activity with inappropriate intake causes negative energy-balance signalling alterations in HTP axes.⁵

Studies on average athletes concerning changes in thyroid hormonal level with exercise training showed a possible increase in TSH and a late increase in T3 and T4 release. Any modification with external temperature regulation during exercise showed no thyroid hormones changes. Based on the intensity and duration of the training, i.e., low (45%), moderate (70%), and high (90%), TSH showed increased levels in all three intensities, T3 and T4, in submaximal intensity. T4 led to an increased status by 35% during prolonged submaximal exercise. Sedentary males, when compared with athletes, showed reduced T4 plasma levels.⁶^,¹⁷^–¹⁹ Thyroid hormones play a crucial role during and after physical activity, and their control is of utmost importance for the proper metabolic pathway function.³^,⁵ Evidence to date shows disputed results concerning thyroid hormone metabolism during exercise in adults and athletes.²^,⁵ However, only scarce information provides knowledge regarding thyroid hormone change status in children and adolescents when subjected to strenuous exercise or physical activity.²^,²⁰^,²¹ Further, to the aim of the current review is to summarise the available existing evidence to identify the effects of all kinds of exercise and physical activity on thyroid hormones in children and adolescents with thyroid function disorder.

Methods

This systematic review is reported according to the PRISMA guidelines. We did a systematic review of randomized and non-randomized controlled trials on the effects of exercise on thyroid hormones in children with thyroid function-related disorders. The study protocol was set and registered in Open Science Framework.

Search strategy and selection criteria

According to PRISMA, the search strategy for the current review was pre-set and executed before study selection. We used the PICOS strategy (population, intervention, comparison, outcome, and study design). A comprehensive systematic search was performed from May 2021 till June 2021 in the following databases: PubMed (MEDLINE, RRID:SCR_002185), Web of Science (Clarivate Analytics, RRID:SCR_017657), CINAHL, SCOPUS (Elsevier, RRID:SCR_013811) and Embase (EMBASE, RRID: SCR_001650). The identification of the articles was made using the search terms “paediatrics”, “child”, “children”, “adolescent”, “thyroid disorders”, “hyperthyroidism”, “hypothyroidism”, “goiter”, “physical therapy”, “exercise training”, “physical activity”, “physical function”, “exercise therapy”, “aerobic exercise”, “physical exercise”, “thyroid hormones”. The search terms were combined with the Boolean operator ‘AND’ or ‘OR’ wherever relevant; secondary searches were carried out using other sources (e.g., Google Scholar, a reference list of the included articles). The current review includes experimental studies (randomised controlled trials [RCTs] and non-randomised controlled trials [non-RCTs]). Investigation studies based on animal populations and non-availability in English were excluded.

Inclusion and exclusion criteria

Inclusion criteria

1) Population: Children aged five to 18 with thyroid function-related disorder.
2) Intervention: Having exercise therapy or any form of physical activity as an intervention. Exercise was defined as “Exercise is a set of physical activity that is planned, structured and repetitive and has a final or intermediate objective of improvement or maintenance of physical fitness”
3) Type of design: RCTs and non-RCTs
4) Type of outcomes: The plasma level of thyroid hormones: triiodothyronine (T3) and thyroxin (T4 & Thyroid-stimulating hormone [TSH]).

Studies that did not include physical activity or exercise as an intervention were excluded, such as those using performance testing and activity questionnaires.

Data extraction and management

The studies eligible for inclusion were screened further based on title and full text independently by BR and VPS (PhD). Any conflict of judgment and agreements were discussed with NSC. A template for data extraction was developed, which included the demographic characteristics of the participants, description of the intervention, comparator, sample size, adverse events, treatment duration, and results in an Excel spreadsheet as reported by the study for all the included articles of this review. Data extraction was done by BR and VPS; any variance was resolved by discussions between the two reviewers and then further with the third reviewer.

Quality assessment

Studies included with the eligibility for the current review were evaluated methodologically and quantified by BR using Downs and Black’s checklist and further reviewed by VPS. The extracted data was updated within the excel sheet based on a pre-set template.

Results

After running a complete search in all the databases with the search strategy, the number of articles obtained was 1713. After merging duplicates using Zotero (Zotero, RRID:SCR_013784) 1,657 articles were accepted for the title and abstract screening, and 20 papers were taken for full-text screening. After all the screening steps, the final eight articles were included in this review.

The PRISMA flowchart (Extended data³²) shows the studies' identification, screening, and inclusion, given in the following PRISMA chart.

The studies included post-data extraction were evaluated for quality and methodology using Downs and Black’s checklist. The studies included for this review showed low to moderate quality of evidence due to poor study designs, sample size, missing data, poor compliance, and follow-up. Details regarding methodological quality are summarized in Table 1. Amid the included eight studies, three were prospective study design; 2 RCT; 1 pre-post research design, one quasi-experimental study, and a cross-sectional comparative study.

Table 1. Quality assessment using modified Downs and Black’s checklist.

Author, year	Reporting (11)	External validity (3)	Internal validity-bias (7)	Internal validity-confounding (selection) (6)	Power (1)	Total score (28)
Sefat et al., 2019²²	8	0	5	2	0	15
Altaye et al., 2019²³	7	3	5	2	0	17
Zenebe et al., 2019²⁴	7	0	4	0	0	11
Wolters et al., 2012²⁵	9	2	3	3	1	18
Reinehr et al., 2006⁹	8	2	3	3	1	17
Licenziati et al., 2009²⁹	8	3	4	3	0	18
Martins et al., 2020²⁷	8	3	3	3	1	18
Wissal Abassi et al., 2020³⁰	8	3	3	4	0	18

Most studies in this review included children with obesity/overweight with altered thyroid functions. Two studies had children with intellectual disabilities, and another study included girls with hypothyroidism. The outcome measures were TSH level and thyroid hormones T3 and T4; some studies measured the free state thyroid hormones (T3 and T4).

Exercise and physical activity were the interventions included in this review. Out of eight studies, three provided resistance training and aerobic exercise. One study compared two groups with high- and moderate-intensity aerobic training,²²^–²⁴ two with Obeldicks weight loss program,⁹^,²⁵ and the other two with supervised physical activity as intervention. The intervention and follow-up period in the included studies ranged from eight weeks to 16 months.

Details regarding the population, study design, sample size, adjuvant treatment, comparator agent, and outcome measures assessed in these studies are summarized in Table 2, and the details of interventions and results are given in Table 3.

Table 2. Provides information regarding author, sample characteristics, design, adjunct therapy along with intervention, comparator for intervention and outcomes of the study.

Author	Sample		Study design	Adjunct therapy	Comparator	Outcome
Author	Population	Age Gender	Study design	Adjunct therapy	Comparator	Outcome
Sefat et al., 2019²²	Hypothyroidism and overweight	8–15 y Females	RCT	levothyroxine	Control no exercise training	TSH and T4
Altaye et al., 2019²³	Adolescents with intellectual disabilities	12-14 y	quasi-experimental design	NA	Control group	TSH, T3, and T4
Zenebe et al., 2019²⁴	intellectual disabilities	12-14 y Females	Pre-post research design	NA	NA	TSH, T3, and T4
Wolters et al., 2012²⁵	obese children	8-12 y	Prospective study	Nutrition education	No comparator	TSH, fT3, and fT4
Reinehr et al., 2006⁹	obese children	8-12 y	cross-sectional comparison	Nutrition education	lean children	TSH, fT3, and fT4
Licenziati et al., 2009²⁹	obese children	4-18 y	longitudinal study	Diet	No comparator	TSH, fT3 and fT4
Martins et al., 2020²⁷	obese children	8–11 y	longitudinal study	Nutrition education	No comparator	TSH, fT3, and fT4
Wissal Abassi et al., 2020³⁰	Obese children	15-17 y	Randomized control trial	No adjunct	No exercise	TSH, T4

Table 3. Changes in Thyroid hormones pre- and post-intervention, * in results indicates significant changes with p <0.05.

Author	Intervention	Details	Duration	Results
	Type	Details	Duration	Results
Sefat et al.,²²	Resistance and aerobic training	Intensity: Resistance- to 60–65% of a maximum replication Aerobic- 70–80% HHR.TIME:75 min: resistance training 30-min: aerobic training TYPE: Resistance-muscular endurance training and muscular strength training. Aerobic- rhythmic movements of the upper body in series of 4 pulses and lower body performed in the series eight pulses	8 weeks	TSH showed a change response from 4.12±1.9 to 6.38±5.2 and T4 value from 6.96±1.1 to 7.62±1.0*
Altaye et al.,²³	Aerobic exercises	Frequency: 3 sessions a week TIME: 30–45min TYPE: 10 min of warm-up exercises, 15–30 min of main aerobic workout and 5min cool-down exercises Provided by- Fitness trainer	16 weeks	The change response in TSH 1.097±0.157, T3-1.713±0.224 and T4-8.349±1.043
Zenebe et al.,²⁴	aerobic exercises	Frequency: 3 sessions a week TIME: 30–45min TYPE: 10 min of warm-up exercises, 15–30 min of main aerobic workout and 5min cool-down exercises Provided by- Fitness trainer	16 weeks	The change response in TSH- 1.142±0.059, T3-1.812±0.182 and T4-8.27±1.741 *
Wolters et al.,²⁵	‘Obeldicks’	Weight loss program: Nutrition program Physical activity and counseling	1-year	TSH value post-intervention changed from 5±1.4to 3±1.5, T3 from 4.2±0.8 to 4.3±1.1 and T4 1.2±0.3 to 1.2±0.4 *
Reinehr et al.,⁹	‘Obeldicks’	Weight loss program: Nutrition program Physical activity and counseling	1- year	The change response was seen with intervention in TSH- 2.6(1.6-3.3), in T3 4.3(3.8-4.9) and T4 1.2(1.1-1.3) *
Licenziati et al.,²⁹	Regular physical activity		1- year	TSH value post-intervention changed from 5.4±1.4 to 4.9±1.5 to 1.2±0.4
Martins et al.,²⁷	Supervised physical activity		16 months	TSH showed change response from 1.48(1.34-1.62) to 0.6(-4.5-1.63), T3 from 5.26(5.10-5.36) to -0.15(-2.46-1.38) and T4 12.17(11.93-12.42) to -0.90(-4.89-2.96)
Wissal Abassi et al.,³⁰	HIIT and MIIT	F-3 sessions/week I- HIIT: 100–110% of MAS & recovery at 50% of MAS I: MIIT- 70–80% MAS & active recovery at 50% of MAS T: Two sets of six repetitions of 30 s running followed by 30 s of active recovery T: 35-40min	12 weeks	TSH changed from 2.2±0.4 to 1.6±0.47 and T3 from 15.3±2.01 to 13.4± 1.35

Discussion

Studies on the effect of exercise on thyroid hormones in the pediatric population are scarce. Earlier studies depicted a transient picture of either increased, decreased or practically unchanged results. The level of alterations in thyroid hormones due to exercise or physical activity depended highly on its type and duration. In addition, adequate nutrition intake is required to negate the negative energy balance, absence of this can alter the endocrine and metabolic profiles. This review summarizes the effects of different types of exercise and physical activity and their duration in a heterogeneous population with thyroid hormonal imbalance in children.

Hypothyroidism

The clinical syndrome of hypothyroidism is caused by a defective production of thyroid hormones; its prevalence among children and adolescents is <2% and is more common in females.¹² Complications of undermanaged hypothyroidism lead to abnormalities of lipid metabolism and reduced insulin sensitivity and glucose tolerance. An RCT conducted by Sefat et al. (2019) evaluated the effect of exercise training on TSH thyroxine (T4) in adolescent girls with hypothyroidism. After eight weeks of aerobic resistance training, the results showed no significant change, with the p-value ≤ 0.05 (TSHμu/mL -0.360 and T4μg/mL- 0.593). The study found no effect on thyroid hormones post-concurrent training but showed significant body fat percentage, BMI, and weight changes. Since the population included was overweight, changes in weight, body composition, and body temperature were associated with thyroid disorders.²²

Two other studies conducted by Zenebe et al. (2019) in children with intellectual disabilities in adolescents and females also reported that the included population was overweight and obese; this is due to children with intellectual disabilities being usually less physically active and with lower levels of thyroid hormones.²⁴^,²⁶ The studies reported the effects of 16 weeks of aerobic exercise training with a frequency of three sessions/week for 30-45min, on changes in plasma concentrations of thyroid hormones. Following previous studies, the results of the studies showed significantly improved T3, T4 (T3: p-value=0.005, T4: p-value=0.0001) levels and decrease in TSH (p-value=0.0001) post-intervention in a study conducted on adolescents and T3, T4 (p-value=0.022 and 0.015, respectively) and p-value=0.28 for TSH in the study conducted on females with intellectual disabilities. The results showed that moderate intensity, i.e., 55-75% of maximum heart rate was an efficient method to improve plasma concentrations of T3, T4, and TSH. Moreover, a four-month duration was too long for achieving equilibrium in TSH and thyroid hormones homeostasis in children with intellectual disabilities. The studies noted that aerobic exercise improves lung function and cognitive changes, leading to a better quality of life.²³^,²⁴

Obesity

Obesity in the pediatric population shows altered thyroid functions, including hyperthyrotropenemia, a condition characterised by an increase of TSH and freeT3 (fT3) concentrations.⁹ Furthermore, subclinical hypothyroidism shows increased TSH concentrations with normal fT3 and free T4(fT4) concentrations.²⁷

Wolters et al. (2012) studied the relationship between TSH and thyroid hormones fT3 fT4 and weight status, as well as their changes, during and after lifestyle intervention. The baseline values in the study of TSH and fT3 were high, and the study results showed differences in TSH and fT3 but not fT4 during the intervention period, which was not significant. The TSH and T3 concentration changes are highly dependent on resting energy expenditure (REE) changes since it is directly proportional to Thyroid hormone concentration.²⁵ In addition, a decrease in energy expenditure due to weight loss has been proven.²⁸ Since the study did not measure REE, it shows that TSH and T3 concentrations may represent an adaptation process of obesity; that is, returning to normal with weight loss and assuming that increase REE to reduce the availability of energy for conversion of fat. Although this study could not show whether thyroid hormones play a role in weight regain, it showed that exercise-induced weight loss showed changes in thyroid hormone production.²⁵

Reinehr et al (2006) did not find significant results in TSH p=0.081, fT4 p=0.156 and fT3 p= 0.386 after intervention. Clinically, TSH and fT3 comparatively decreased but in fT4 levels did not. Since T3 regulates both resting metabolic rate and thermogenesis, changes in thyroid hormones could reflect an adaptation process in obesity, i.e., REE directly proportional to TH changes.⁹^,²⁸ This represents a factor in the difficulty to maintain weight loss. The authors also hypothesized that hyperthyrotropenemia in obesity required no treatment.⁸

Licenziati and Martin et al. (2009) studied thyroid function changes in children subjected to regular physical activity with lifestyle modifications. Children who showed a decrease in BMI showed a decrease in TSH (p <0.0001), where the decrease depended on the extent of weight loss, hence proving an association between BMI and TSH. They also observed structural changes in the thyroid gland, which returned to normal.²⁷^,²⁹

Wissal Abassi et al. (2020) showed improving thyroid function status in children post-high-intensity interval training compared with moderate-intensity interval training and no exercise. The change in the response witnessed can be due to intensity- and leptin production-induced hypothalamic hormonal regulation.⁵ The reduction in body fat corresponds to reduced resting metabolism energy, increasing basal metabolism, and regulating thyroid function level.⁵^,²⁸ Based on these reasons, the group subjected to high-intensity training showed better change response when compared to other groups, thus showing exercise intensity is directly proportional to changes in thyroid functions.²⁸

Exercise, or any form of regular physical activity leads to changes in BMI related to thyroid hormones.⁹^,²⁵^,²⁷ No significant study evidenced thyroid hormones returning to normal within the intervention period or post it. However, studies showed some changes in thyroid hormones due to exercise or physical activity linked with weight loss. Weight loss can be achieved through diet, bariatric surgery, or exercise.

Exercise benefits in decreased BMI with changes in cardiovascular adaptations, increase in muscular strength, and improve the quality of life of children and adolescents with thyroid function disorders.⁹^,²²^,²⁵^–²⁷^,²⁹^–³¹

Conclusions

Studies with aerobic exercise training for eight to 16 weeks show benefits in improving thyroid functions. However, the study quality was low-level. Regular exercise or physical activity practiced for a longer duration helped reduce weight, influencing thyroid functions to be normal in this population. The extent of change was directly proportional to exercise intensity. However, this review does not provide sufficient evidence stating that exercise results in changes in thyroid function returning to normal, which requires further higher-quality studies to strengthen the review's findings.

Data availability

Underlying data

Open Science Framework: Effects of exercise on thyroid functions in children with thyroid disorders, https://osf.io/392r4.³²

This project contains the following underlying data:

- Data extraction (AutoRecovered).xlsx
- PRISMA_2020_checklist.docx
- Study protocol.docx
- PRISMA flow chart

Data are available under the terms of the Creative Commons Zero “No rights reserved” data waiver (CC0 1.0 Public domain dedication).

References

1. Rivas M, Naranjo JR: Thyroid hormones, learning and memory. Genes Brain Behav. 2007 Jun; 6: 40–44. Publisher Full Text
2. Kanaka-Gantenbein C: The Impact of Exercise on Thyroid Hormone Metabolism in Children and Adolescents. Horm. Metab. Res. 2005 Sep [cited 2022 Feb 17]; 37(9): 563–565. PubMed Abstract | Publisher Full Text
3. Riddell MC: The endocrine response and substrate utilization during exercise in children and adolescents. J. Appl. Physiol. 2008 Aug [cited 2022 Feb 17]; 105(2): 725–733. PubMed Abstract | Publisher Full Text
4. Yen PM: Physiological and molecular basis of thyroid hormone action. Physiol. Rev. 2001 Jul; 81(3): 1097–1142. PubMed Abstract | Publisher Full Text
5. Mullur R, Liu Y-Y, Brent GA: Thyroid Hormone Regulation of Metabolism. Physiol. Rev. 2014 Apr [cited 2021 Jun 21]; 94(2): 355–382. PubMed Abstract | Publisher Full Text Reference Source
6. Juul A, Jorgensen JOL, Christiansen JS, et al.: Metabolic effects of GH: A rationale for continued GH treatment of GH-deficient adults after cessation of linear growth. Horm. Res. 1995; 44(SUPPL. 3): 64–72. PubMed Abstract | Publisher Full Text Reference Source
7. Canali ES, Kruel LFM: Hormonal responses to exercise. Rev Paul Educ Física. 2001 Dec 20 [cited 2022 Feb 18]; 15(2): 141–153. Publisher Full Text Reference Source
8. Rumińska M, Witkowska-Sędek E, Majcher A, Pyrżak B: Prospect in Pediatric Diseases Medicine.2016 [cited 2021 Jun 18]. Publisher Full Text
9. Reinehr T, Andler W: Thyroid hormones before and after weight loss in obesity. Arch. Dis. Child. 2002; 87(4): 320–323. PubMed Abstract | Publisher Full Text | Free Full Text Reference Source
10. Laurberg P, Knudsen N, Andersen S, et al.: Thyroid Function and Obesity. Eur. Thyroid J. 2012 [cited 2022 Feb 17]; 1(3): 159–167. PubMed Abstract | Publisher Full Text
11. Hackney AC, McMurray RG, Judelson DA, et al.: Relationship between Caloric Intake, Body Composition, and Physical Activity to Leptin, Thyroid Hormones, and Cortisol in Adolescents. Jpn. J. Physiol. 2003; 53(6): 475–479. PubMed Abstract | Publisher Full Text
12. Hanley P, Lord K, Bauer AJ: Thyroid Disorders in Children and Adolescents: A Review. JAMA Pediatr. 2016 Oct 1 [cited 2021 Jun 21]; 170(10): 1008. Publisher Full Text
13. Bettendorf M: Thyroid disorders in children from birth to adolescence. Eur. J. Nucl. Med. Mol. Imaging. 2002 Aug [cited 2022 Feb 18]; 29(S2): S439–S446. Publisher Full Text
14. Salvatore D, Simonides WS, Dentice M, et al.: Thyroid hormones and skeletal muscle — new insights and potential implications. Nat. Rev. Endocrinol. 2014 Apr [cited 2022 Feb 18]; 10(4): 206–214. PubMed Abstract | Publisher Full Text Reference Source
15. Richmond E, Rogol AD: Endocrine Responses to Exercise in the Developing Child and Adolescent.Lanfranco F, Strasburger CJ, editors. Frontiers of Hormone Research. S. Karger AG; 2016 [cited 2022 Feb 17]; p. 58–67. Reference Source
16. Arkader R: Physiological Changes of Exercise of Thermogenesis, Thyroid Homeostasis and Inflammation. Endocrinol Int J. 2016 Oct 14 [cited 2022 Feb 17]; 3(4). Publisher Full Text Reference Source
17. Deligiannis A, Karamouzis M, Kouidi E, et al.: Plasma TSH, T3, T4 and cortisol responses to swimming at varying water temperatures. Br. J. Sports Med. 1993 Dec [cited 2022 Feb 18]; 27(4): 247–50. PubMed Abstract | Publisher Full Text | Free Full Text
18. Ciloglu F, Peker I, Pehlivan A, et al.: Exercise intensity and its effects on thyroid hormones. Neuroendocrinol. Lett. 2005; 26(6): 830–834. PubMed Abstract
19. Mastorakos G, Pavlatou M: Exercise as a stress model and the interplay between the hypothalamus-pituitary-adrenal and the hypothalamus-pituitary-thyroid axes. Horm. Metab. Res. Horm. Stoffwechselforschung Horm. Metab. 2005 Sep; 37(9): 577–584. PubMed Abstract | Publisher Full Text
20. American Academy of Pediatrics. Committee on Sports Medicine and Fitness. Medical concerns in the female athlete. Pediatrics. 2000 Sep; 106(3): 610–613. PubMed Abstract | Publisher Full Text
21. Jahreis G, Kauf E, Fröhner G, et al.: Influence of intensive exercise on insulin-like growth factor I, thyroid and steroid hormones in female gymnasts. Growth Regul. 1991 Sep; 1(3): 95–99. PubMed Abstract
22. Mohammadi Sefat S, Shabani R, Nazari M: The effect of concurrent aerobic-resistance training on thyroid hormones, blood glucose hemostasis, and blood lipid indices in overweight girls with hypothyroidism. Horm Mol Biol. Clin. Investig. 2019 Oct 16; 40(3).
23. Altaye KZ, Mondal S, Legesse Z, et al.: Effects of aerobic exercise on thyroid hormonal change responses among adolescents with intellectual disabilities. BMJ Open Sport Exerc. Med. 2019; 5(1): e000524. PubMed Abstract | Publisher Full Text
24. Zenebe K, Mondal S, Legesse K, et al.: Impacts of aerobic exercises on thyroid hormonal change responses of females’ children with intellectual disabilities. Int. J. Physiol. Nutr. Phys. Educ.
25. Wolters B, Lass N, Reinehr T: TSH and free triiodothyronine concentrations are associated with weight loss in a lifestyle intervention and weight regain afterwards in obese children. Eur. J. Endocrinol. 2013 Mar; 168(3): 323–329. PubMed Abstract | Publisher Full Text
26. Altaye KZ, Mondal S, Legesse K, et al.: Effects of aerobic exercise on thyroid hormonal change responses among adolescents with intellectual disabilities. BMJ Open Sport Exerc. Med. 2019 Jul [cited 2022 Feb 18]; 5(1): e000524. PubMed Abstract | Publisher Full Text
27. Martins VJB, Filgueiras AR, Almeida VBP, et al.: Changes in thyroid and glycemic status and food intake in children with excess weight who were submitted for a multi-component school intervention for 16 months. Int. J. Environ. Res. Public Health. 2020; 17(11). PubMed Abstract | Publisher Full Text
28. Hill JO; Anschutz Health & Wellness Center, University of Colorado, Aurora, Colorado, US, Wyatt HR, Anschutz Health & Wellness Center, University of Colorado, Aurora, Colorado, US, Peters JC, Anschutz Health & Wellness Center, University of Colorado, Aurora, Colorado, US: The Importance of Energy Balance. Eur Endocrinol. 2010 [cited 2022 Mar 3]; 9(2): 111–115. PubMed Abstract | Publisher Full Text Reference Source
29. Licenziati MR, Valerio G, Vetrani I, et al.: Altered Thyroid Function and Structure in Children and Adolescents Who Are Overweight and Obese: Reversal After Weight Loss. J. Clin. Endocrinol. Metab. 2019 Jul 1; 104(7): 2757–2765. PubMed Abstract | Publisher Full Text
30. Abassi W, Ouerghi N, Ghouili H, et al.: Greater effects of high- compared with moderate-intensity interval training on thyroid hormones in overweight/obese adolescent girls. Horm. Mol. Biol. Clin. Invest. 2020 Dec 14 [cited 2022 Feb 11]; 41(4): 20200031. PubMed Abstract | Publisher Full Text
31. Zenebe K, Mondal S, Legesse K, et al.: Impacts of aerobic exercises on thyroid hormonal change responses of females’ children with intellectual disabilities. Int. J. Physiol. 3.
32. R, BSingh P, Chauhan NS: Effects of exercise on thyroid functions in children with thyroid disorders.2022, February 24. Publisher Full Text

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VERSION 1 PUBLISHED 15 Mar 2022

Author details Author details

¹ Department of Physiotherapy, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India, Mangalore, India

Bindya Rajashekar
Roles: Conceptualization, Data Curation, Formal Analysis, Funding Acquisition, Investigation, Methodology, Project Administration, Resources, Software, Supervision, Validation, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing

Vijay Pratap Singh
Roles: Conceptualization, Data Curation, Formal Analysis, Funding Acquisition, Investigation, Methodology, Project Administration, Resources, Software, Supervision, Validation, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing

Namrata Singh Chauhan
Roles: Funding Acquisition, Investigation, Methodology, Project Administration, Resources, Software, Supervision, Validation, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing

Competing interests

No competing interests were disclosed.

Grant information

The author(s) declared that no grants were involved in supporting this work.

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Published: 15 Mar 2022, 11:313

https://doi.org/10.12688/f1000research.109949.1

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Rajashekar B, Singh VP and Singh Chauhan N. Effects of exercise on thyroid hormones in children and adolescents with thyroid function disorders: A Systematic Review [version 1; peer review: 1 approved, 1 approved with reservations]. F1000Research 2022, 11:313 (https://doi.org/10.12688/f1000research.109949.1)

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Reviewer Report 07 Jul 2023

Amine Souissi, Université de Sousse, Sousse, Tunisia

Approved with Reservations

https://doi.org/10.5256/f1000research.121511.r179152

Editorial Note from F1000Research 26/07/2023: A co-reviewer was added to a previous version of this report in error. They have now been removed. The content remains the same.

Firstly, I would like to congratulate the author/s on ... Continue reading

Editorial Note from F1000Research 26/07/2023: A co-reviewer was added to a previous version of this report in error. They have now been removed. The content remains the same.

Firstly, I would like to congratulate the author/s on conducting this research and preparing this manuscript. The topic is interesting; however, there are several mistakes that should be corrected. The author aimed to identify the effects of exercise on thyroid hormones in children and adolescents with thyroid function disorders, but I haven't found anything in the introduction about thyroid function disorders in children and adolescents. Therefore, the author should introduce a section detailing this. Moreover, there is sometimes confusion about the effect of acute exercise and training on thyroid function. Furthermore, in the discussion the author should focus on the results of the present review, the author (almost) only discusses the results of previous studies. I think that all the papers should be improved. Clearly, there's a lot of work to be done. I feel that it could be suitable for publication in the journal but not in its current form. I suggest a “major revision”. Good luck.

Please find my specific comments in the attached file (PDF)

Are the rationale for, and objectives of, the Systematic Review clearly stated?

No
Are sufficient details of the methods and analysis provided to allow replication by others?

No
Is the statistical analysis and its interpretation appropriate?

I cannot comment. A qualified statistician is required.
Are the conclusions drawn adequately supported by the results presented in the review?

Partly

Competing Interests: No competing interests were disclosed.

Reviewer Expertise: Exercise Physiology; Thermoregulation; Sports Cardiology

I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.

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Reviewer Report 11 Apr 2022

Gita Negi, Department of Transfusion Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India

Approved

https://doi.org/10.5256/f1000research.121511.r127948

The review aims to identify the impact on thyroid hormone levels in children and adolescents with thyroid function disorder when subjected to exercise; describing the exercise as a set of physical activities that are planned, structured and repetitive and has ... Continue reading

The review aims to identify the impact on thyroid hormone levels in children and adolescents with thyroid function disorder when subjected to exercise; describing the exercise as a set of physical activities that are planned, structured and repetitive and has set an objective of improvement or maintenance of physical fitness. The studies included interventions ranging from regular to structured exercise. The review summarizes the effects of changes in thyroid hormone levels based on exercise intensity and duration among five to 18-year-old subjects, thus throwing some light on change intensity in children and adolescents when subjected to different types of exercise. Furthermore, the outcome involves adjunct therapy in addition to exercise. The parameters included in the review consists of hypothyroidism, intellectual disability, and obesity, associated with altered hormonal levels. The findings have been summarized based on these populations showing change responses when subjected to high or low-intensity exercise or physical activity for long duration.

The review provides evidence showing that exercise intensity is related to the intensity of change in outcome. Since the review findings are not confined to a specific population or age range, although the clinical implications can be extrapolated to people with thyroid function disorder; however, the quality of evidence is low to moderate which the authors have humbly expressed as well and have recommended further large scale studies. Further, the review does address the existing knowledge gap regarding the effects of exercise in the population.

Are the rationale for, and objectives of, the Systematic Review clearly stated?

Yes
Are sufficient details of the methods and analysis provided to allow replication by others?

Yes
Is the statistical analysis and its interpretation appropriate?

Yes
Are the conclusions drawn adequately supported by the results presented in the review?

Yes

Competing Interests: No competing interests were disclosed.

Reviewer Expertise: Pathology, Transfusion Medicine, Medical education

I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.

CITE

Report a concern

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Version 1 15 Mar 22	read	read

Gita Negi, All India Institute of Medical Sciences, Rishikesh, India
Amine Souissi, Université de Sousse, Sousse, Tunisia

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Reviewer Report

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07 Jul 2023 | for Version 1

Amine Souissi, Université de Sousse, Sousse, Tunisia

13 Views Cite this report Responses(0)

Approved With Reservations

Editorial Note from F1000Research 26/07/2023: A co-reviewer was added to a previous version of this report in error. They have now been removed. The content remains the same.

Firstly, I would like to congratulate the author/s on conducting this research and preparing this manuscript. The topic is interesting; however, there are several mistakes that should be corrected. The author aimed to identify the effects of exercise on thyroid hormones in children and adolescents with thyroid function disorders, but I haven't found anything in the introduction about thyroid function disorders in children and adolescents. Therefore, the author should introduce a section detailing this. Moreover, there is sometimes confusion about the effect of acute exercise and training on thyroid function. Furthermore, in the discussion the author should focus on the results of the present review, the author (almost) only discusses the results of previous studies. I think that all the papers should be improved. Clearly, there's a lot of work to be done. I feel that it could be suitable for publication in the journal but not in its current form. I suggest a “major revision”. Good luck.

Please find my specific comments in the attached file (PDF)

Are the rationale for, and objectives of, the Systematic Review clearly stated?

No
Are sufficient details of the methods and analysis provided to allow replication by others?

No
Is the statistical analysis and its interpretation appropriate?

I cannot comment. A qualified statistician is required.
Are the conclusions drawn adequately supported by the results presented in the review?

Partly

Competing Interests

No competing interests were disclosed.

Reviewer Expertise

Exercise Physiology; Thermoregulation; Sports Cardiology

I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.

Respond to this report

Responses (0)

Back to all reports

Reviewer Report

17 Views

11 Apr 2022 | for Version 1

Gita Negi, Department of Transfusion Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India

17 Views Cite this report Responses(0)

Approved

The review aims to identify the impact on thyroid hormone levels in children and adolescents with thyroid function disorder when subjected to exercise; describing the exercise as a set of physical activities that are planned, structured and repetitive and has set an objective of improvement or maintenance of physical fitness. The studies included interventions ranging from regular to structured exercise. The review summarizes the effects of changes in thyroid hormone levels based on exercise intensity and duration among five to 18-year-old subjects, thus throwing some light on change intensity in children and adolescents when subjected to different types of exercise. Furthermore, the outcome involves adjunct therapy in addition to exercise. The parameters included in the review consists of hypothyroidism, intellectual disability, and obesity, associated with altered hormonal levels. The findings have been summarized based on these populations showing change responses when subjected to high or low-intensity exercise or physical activity for long duration.

The review provides evidence showing that exercise intensity is related to the intensity of change in outcome. Since the review findings are not confined to a specific population or age range, although the clinical implications can be extrapolated to people with thyroid function disorder; however, the quality of evidence is low to moderate which the authors have humbly expressed as well and have recommended further large scale studies. Further, the review does address the existing knowledge gap regarding the effects of exercise in the population.

Are the rationale for, and objectives of, the Systematic Review clearly stated?

Yes
Are sufficient details of the methods and analysis provided to allow replication by others?

Yes
Is the statistical analysis and its interpretation appropriate?

Yes
Are the conclusions drawn adequately supported by the results presented in the review?

Yes

Competing Interests

No competing interests were disclosed.

Reviewer Expertise

Pathology, Transfusion Medicine, Medical education

I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.

Respond to this report

Responses (0)

[1] 1. Rivas M, Naranjo JR: Thyroid hormones, learning and memory. Genes Brain Behav. 2007 Jun; 6: 40–44. Publisher Full Text

[2] 2. Kanaka-Gantenbein C: The Impact of Exercise on Thyroid Hormone Metabolism in Children and Adolescents. Horm. Metab. Res. 2005 Sep [cited 2022 Feb 17]; 37(9): 563–565. PubMed Abstract | Publisher Full Text

[3] 3. Riddell MC: The endocrine response and substrate utilization during exercise in children and adolescents. J. Appl. Physiol. 2008 Aug [cited 2022 Feb 17]; 105(2): 725–733. PubMed Abstract | Publisher Full Text

[4] 4. Yen PM: Physiological and molecular basis of thyroid hormone action. Physiol. Rev. 2001 Jul; 81(3): 1097–1142. PubMed Abstract | Publisher Full Text

[5] 5. Mullur R, Liu Y-Y, Brent GA: Thyroid Hormone Regulation of Metabolism. Physiol. Rev. 2014 Apr [cited 2021 Jun 21]; 94(2): 355–382. PubMed Abstract | Publisher Full Text Reference Source

[6] 6. Juul A, Jorgensen JOL, Christiansen JS, et al.: Metabolic effects of GH: A rationale for continued GH treatment of GH-deficient adults after cessation of linear growth. Horm. Res. 1995; 44(SUPPL. 3): 64–72. PubMed Abstract | Publisher Full Text Reference Source

[7] 7. Canali ES, Kruel LFM: Hormonal responses to exercise. Rev Paul Educ Física. 2001 Dec 20 [cited 2022 Feb 18]; 15(2): 141–153. Publisher Full Text Reference Source

[8] 8. Rumińska M, Witkowska-Sędek E, Majcher A, Pyrżak B: Prospect in Pediatric Diseases Medicine.2016 [cited 2021 Jun 18]. Publisher Full Text

[9] 9. Reinehr T, Andler W: Thyroid hormones before and after weight loss in obesity. Arch. Dis. Child. 2002; 87(4): 320–323. PubMed Abstract | Publisher Full Text | Free Full Text Reference Source

[10] 10. Laurberg P, Knudsen N, Andersen S, et al.: Thyroid Function and Obesity. Eur. Thyroid J. 2012 [cited 2022 Feb 17]; 1(3): 159–167. PubMed Abstract | Publisher Full Text

[11] 11. Hackney AC, McMurray RG, Judelson DA, et al.: Relationship between Caloric Intake, Body Composition, and Physical Activity to Leptin, Thyroid Hormones, and Cortisol in Adolescents. Jpn. J. Physiol. 2003; 53(6): 475–479. PubMed Abstract | Publisher Full Text

[12] 12. Hanley P, Lord K, Bauer AJ: Thyroid Disorders in Children and Adolescents: A Review. JAMA Pediatr. 2016 Oct 1 [cited 2021 Jun 21]; 170(10): 1008. Publisher Full Text

[13] 13. Bettendorf M: Thyroid disorders in children from birth to adolescence. Eur. J. Nucl. Med. Mol. Imaging. 2002 Aug [cited 2022 Feb 18]; 29(S2): S439–S446. Publisher Full Text

[14] 14. Salvatore D, Simonides WS, Dentice M, et al.: Thyroid hormones and skeletal muscle — new insights and potential implications. Nat. Rev. Endocrinol. 2014 Apr [cited 2022 Feb 18]; 10(4): 206–214. PubMed Abstract | Publisher Full Text Reference Source

[15] 15. Richmond E, Rogol AD: Endocrine Responses to Exercise in the Developing Child and Adolescent.Lanfranco F, Strasburger CJ, editors. Frontiers of Hormone Research. S. Karger AG; 2016 [cited 2022 Feb 17]; p. 58–67. Reference Source

[16] 16. Arkader R: Physiological Changes of Exercise of Thermogenesis, Thyroid Homeostasis and Inflammation. Endocrinol Int J. 2016 Oct 14 [cited 2022 Feb 17]; 3(4). Publisher Full Text Reference Source

[17] 17. Deligiannis A, Karamouzis M, Kouidi E, et al.: Plasma TSH, T3, T4 and cortisol responses to swimming at varying water temperatures. Br. J. Sports Med. 1993 Dec [cited 2022 Feb 18]; 27(4): 247–50. PubMed Abstract | Publisher Full Text | Free Full Text

[18] 18. Ciloglu F, Peker I, Pehlivan A, et al.: Exercise intensity and its effects on thyroid hormones. Neuroendocrinol. Lett. 2005; 26(6): 830–834. PubMed Abstract

[19] 19. Mastorakos G, Pavlatou M: Exercise as a stress model and the interplay between the hypothalamus-pituitary-adrenal and the hypothalamus-pituitary-thyroid axes. Horm. Metab. Res. Horm. Stoffwechselforschung Horm. Metab. 2005 Sep; 37(9): 577–584. PubMed Abstract | Publisher Full Text

[20] 20. American Academy of Pediatrics. Committee on Sports Medicine and Fitness. Medical concerns in the female athlete. Pediatrics. 2000 Sep; 106(3): 610–613. PubMed Abstract | Publisher Full Text

[21] 21. Jahreis G, Kauf E, Fröhner G, et al.: Influence of intensive exercise on insulin-like growth factor I, thyroid and steroid hormones in female gymnasts. Growth Regul. 1991 Sep; 1(3): 95–99. PubMed Abstract

[22] 22. Mohammadi Sefat S, Shabani R, Nazari M: The effect of concurrent aerobic-resistance training on thyroid hormones, blood glucose hemostasis, and blood lipid indices in overweight girls with hypothyroidism. Horm Mol Biol. Clin. Investig. 2019 Oct 16; 40(3).

[23] 23. Altaye KZ, Mondal S, Legesse Z, et al.: Effects of aerobic exercise on thyroid hormonal change responses among adolescents with intellectual disabilities. BMJ Open Sport Exerc. Med. 2019; 5(1): e000524. PubMed Abstract | Publisher Full Text

[24] 24. Zenebe K, Mondal S, Legesse K, et al.: Impacts of aerobic exercises on thyroid hormonal change responses of females’ children with intellectual disabilities. Int. J. Physiol. Nutr. Phys. Educ.

[25] 25. Wolters B, Lass N, Reinehr T: TSH and free triiodothyronine concentrations are associated with weight loss in a lifestyle intervention and weight regain afterwards in obese children. Eur. J. Endocrinol. 2013 Mar; 168(3): 323–329. PubMed Abstract | Publisher Full Text

[26] 26. Altaye KZ, Mondal S, Legesse K, et al.: Effects of aerobic exercise on thyroid hormonal change responses among adolescents with intellectual disabilities. BMJ Open Sport Exerc. Med. 2019 Jul [cited 2022 Feb 18]; 5(1): e000524. PubMed Abstract | Publisher Full Text

[27] 27. Martins VJB, Filgueiras AR, Almeida VBP, et al.: Changes in thyroid and glycemic status and food intake in children with excess weight who were submitted for a multi-component school intervention for 16 months. Int. J. Environ. Res. Public Health. 2020; 17(11). PubMed Abstract | Publisher Full Text

[28] 28. Hill JO; Anschutz Health & Wellness Center, University of Colorado, Aurora, Colorado, US, Wyatt HR, Anschutz Health & Wellness Center, University of Colorado, Aurora, Colorado, US, Peters JC, Anschutz Health & Wellness Center, University of Colorado, Aurora, Colorado, US: The Importance of Energy Balance. Eur Endocrinol. 2010 [cited 2022 Mar 3]; 9(2): 111–115. PubMed Abstract | Publisher Full Text Reference Source

[29] 29. Licenziati MR, Valerio G, Vetrani I, et al.: Altered Thyroid Function and Structure in Children and Adolescents Who Are Overweight and Obese: Reversal After Weight Loss. J. Clin. Endocrinol. Metab. 2019 Jul 1; 104(7): 2757–2765. PubMed Abstract | Publisher Full Text

[30] 30. Abassi W, Ouerghi N, Ghouili H, et al.: Greater effects of high- compared with moderate-intensity interval training on thyroid hormones in overweight/obese adolescent girls. Horm. Mol. Biol. Clin. Invest. 2020 Dec 14 [cited 2022 Feb 11]; 41(4): 20200031. PubMed Abstract | Publisher Full Text

[31] 31. Zenebe K, Mondal S, Legesse K, et al.: Impacts of aerobic exercises on thyroid hormonal change responses of females’ children with intellectual disabilities. Int. J. Physiol. 3.

[32] 32. R, BSingh P, Chauhan NS: Effects of exercise on thyroid functions in children with thyroid disorders.2022, February 24. Publisher Full Text

Effects of exercise on thyroid hormones in children and adolescents with thyroid function disorders: A Systematic Review

Abstract

Keywords

Introduction

Methods

Search strategy and selection criteria

Inclusion and exclusion criteria

Data extraction and management

Quality assessment

Results

Table 1. Quality assessment using modified Downs and Black’s checklist.

Table 2. Provides information regarding author, sample characteristics, design, adjunct therapy along with intervention, comparator for intervention and outcomes of the study.

Table 3. Changes in Thyroid hormones pre- and post-intervention, * in results indicates significant changes with p <0.05.

Discussion

Hypothyroidism

Obesity

Conclusions

Data availability

Underlying data

References

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