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DOI: 10.12688/f1000research.8705.1
Assessment of pharmacogenomic agreement [version 1; referees: awaiting peer review]
Zhaleh Safikhani, Nehme El-Hachem, Rene Quevedo, Petr Smirnov, Anna Goldenberg, Nicolai Juul Birkbak, Christopher Mason, Christos Hatzis, Leming Shi, Hugo JWL Aerts, John Quackenbush, Benjamin Haibe-Kains
Referees: Invited
PUBLISHED 09 May 2016
DOI: 10.12688/f1000research.7800.2
Research Note
Does inactivation of USP14 enhance degradation of proteasomal substrates that are associated with neurodegenerative diseases? [version 2; referees: 3 approved]
Daniel Ortuno, Holly J. Carlisle, Silke Miller
Referees: Scott T Brady F1000Research Advisory Board member
F1000Prime Faculty Member
; Thomas Kodadek F1000Prime Faculty Member
; Scott Wilson
PUBLISHED 25 Apr 2016
DOI: 10.12688/f1000research.8548.1
Research Article
Uptake of dietary milk miRNAs by adult humans: a validation study [version 1; referees: 3 approved]
Amanda Auerbach, Gopi Vyas, Anne Li, Marc Halushka, Kenneth Witwer
Referees: Cherie Blenkiron; Jens Allmer; Hervé Seitz
PUBLISHED 22 Apr 2016
DOI: 10.12688/f1000research.7868.2
Research Note
Effect of LXR/RXR agonism on brain and CSF Aβ40 levels in rats [version 2; referees: 1 approved, 2 approved with reservations]
Songli Wang, Paul Wen, Stephen Wood
Referees: Sam Gandy F1000Prime Faculty Member
; Mary Jo LaDu, Conor Smith and Ana Valencia; Daniel M. Michaelson
PUBLISHED 19 Apr 2016
DOI: 10.12688/f1000research.8236.1
Research Article
In search of the mechanisms of ketamine’s antidepressant effects: How robust is the evidence behind the mTor activation hypothesis [version 1; referees: 1 approved, 1 approved with reservations]
Susanna Popp, Berthold Behl, Jaya Julie Joshi, Thomas A. Lanz, Michael Spedding, Esther Schenker, Therese M Jay, Per Svenningsson, Dorian Caudal, Jacob I. Cunningham, Daniel Deaver, Anton Bespalov
Referees: John D. Graef; Eero Castrén and Plinio Casarotto
PUBLISHED 11 Apr 2016
DOI: 10.12688/f1000research.7822.1
Research Note
GPR21 KO mice demonstrate no resistance to high fat diet induced obesity or improved glucose tolerance [version 1; referees: 1 approved, 2 approved with reservations]
Jinghong Wang, Zheng Pan, Helene Baribault, Danny Chui, Caroline Gundel, Murielle Véniant
Referees: Mary Pelleymounter; Richard Neubig; Michelle Kimple
PUBLISHED 04 Feb 2016
DOI: 10.12688/f1000research.7847.1
Publishing confirming and non-confirming data [version 1; referees: not peer reviewed]
Bruce Alberts, Alexander Kamb
PUBLISHED 04 Feb 2016
DOI: 10.12688/f1000research.6735.1
Research Note
Questioned validity of Gene Expression Dysregulated Domains in Down's Syndrome [version 1; referees: 2 approved]
Long H. Do, William C. Mobley F1000Prime Faculty Member
Nishant Singhal
Referees: Jon Pierce-Shimomura and Sarah Nordquist; Roger Reeves
PUBLISHED 17 Jul 2015
DOI: 10.12688/f1000research.6743.2
Research Article
Re-analysis of metagenomic sequences from acute flaccid myelitis patients reveals alternatives to enterovirus D68 infection [version 2; referees: 2 approved]
Florian P. Breitwieser, Carlos A. Pardo, Steven L. Salzberg F1000Prime Faculty Member
Referees: David Lipman F1000Prime Section Head
; Yoav Gilad
PUBLISHED 13 Jul 2015
DOI: 10.12688/f1000research.6536.1
Research Article
A reanalysis of mouse ENCODE comparative gene expression data [version 1; referees: 3 approved, 1 approved with reservations]
Yoav Gilad, Orna Mizrahi-Man
Referees: Rafael Irizarry; Michael Eisen F1000Prime International Advisory Board Member
; Mick Watson F1000Prime Faculty Member
; Lior Pachter
PUBLISHED 19 May 2015
DOI: 10.12688/f1000research.2-140.v1
Research Article
Environmental enrichment does not impact on tumor growth in mice [version 1; referees: 2 approved]
Jennifer A Westwood, Phillip K Darcy, Michael H Kershaw
Referees: Marc Pellegrini F1000Research Advisory Board member
F1000Prime Faculty Member
; Stephen Nutt F1000Research Advisory Board member
F1000Prime Faculty Member
PUBLISHED 12 Jun 2013

The Preclinical Reproducibility and Robustness channel is a platform for open and transparent publication of confirmatory and non-confirmatory studies in biomedical research. The channel is open to all scientists from both academia and industry and provides a centralized space for researchers to start an open dialogue, thereby helping to improve the reproducibility of studies. Please note, submissions to this channel are subject to an article processing charge (APC). For more information, please click here

How does the channel work?

The channel is open for submission to all research scientists (academia and industry) who want to publish a confirming or non-confirming replication study on condition that they provide the full methodology and data to support their claims.

Each publication will undergo a fully transparent post-publication peer review following the F1000Research publication model. Referee reports from invited named experts will be posted alongside the article, allowing readers to get a full picture of the soundness of the replication experiments.

F1000Research recommends that authors raise any concerns about previous studies directly with the original authors before publishing their replication attempts. The authors whose studies have been confirmed or not confirmed can provide signed comments on the article, or publish their own full Correspondence article (which would also be openly peer-reviewed) in the channel if they have further (published or new) evidence that adds to the discussion (see our Correspondence article guidelines here).

The overall goal of the channel is to enable meaningful scientific discourse that is open and publicly available and aids the rapid progression of science.


Bruce Alberts University of California, San Francisco
Alexander Kamb Amgen Inc.
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